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Arthritis
(from Greek arthro-, joint + -itis, inflammation) is a form of joint disorder that involves inflammation of one or more joints.
CollinsDictionary.com. Collins English Dictionary Complete & Unabridged 11th Edition.
(degenerative joint disease), is a result of trauma to the joint, infection of the joint, or age.
psoriatic arthritis,
related autoimmune
diseases.
Septic arthritis is caused
by joint infection.
The pain from arthritis is due to inflammation that occurs around the joint, damage to the joint from disease, daily wear and tear of joint muscle strains caused by forceful movements against stiff painful joints and fatigue.
Rheumatoid arthritis Weeks-months[16] Hands (proximal interphalangeal and metacarpophalangeal joint) wrists, ankles and knees Yes
Weight-bearing joints (such as knees, hips, vertebral column) and hands Inflammation May occur, though often mild compared to inflammation in rheumatoid arthritis Radiologic changes Narrowed joint space Osteophytes Laboratory findings None
Local osteosclerosis Anemia, elevated ESR and C-reactive protein (CRP), rheumatoid factor, anticitrullinated protein antibody Ulnar deviation, swan neck- and Boutonniere deformity of the hand Extra-articular features are common
Other features
Synoviocytes (fibroblasts and macrophages) also actively synthesize proteases and cytokines which can negatively effect on the articular cartilage and synovium. Pathophysiological changes in synoviocytes pave the way for angiogenesis and innervations, which may account for OA pain. Adapted from S. B. Abramson and M. Attur, Arthritis Res Ther 2009;11(3):227.
Molecules implicated in the innate immune response within the damaged joint, each potentially contributing to the chronic inflammation observed in OA