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Vitamin C helps protect cells "Vitamin C keeps cancer at bay, US research suggests," was the inaccurate headline on the BBC News website. The study it reports on did not find that highdose vitamin C helped with cancer survival, although it did appear to show it reduced some chemotherapy-related side effects. The study actually looked at whether vitamin C could improve the effectiveness of chemotherapy specifically for women with late-stage ovarian cancer. The vitamin C doses were given intravenously (not as tablets or food) in both mice and humans. The part of the trial conducted on people was too small to prove whether vitamin C helped kill cancer cells or increased survival from cancer up to five years after diagnosis. The results were not statistically significant, and any beneficial effects could have been down to chance alone. However, the research did suggest that vitamin C may reduce chemotherapy side effects for women, but again it was too small to prove it with any confidence. It's also worth noting that the women knew whether they were given vitamin C, so the placebo effect may have influenced their reporting of side effects. Potential treatments that reduce the unpleasant side effects of chemotherapy (or improve its effectiveness) are worth investigating. But vitamin C's effect on cancer survival, or on reducing side effects, is not yet proven. A large human clinical trial investigating the intravenous effects of vitamin C, combined with standard chemotherapy, in a range of cancers would answer many of the outstanding questions this preliminary study has raised, and address its limitations.
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However, early research involving giving people vitamin C orally (through the mouth) showed no beneficial effects, so this avenue of research was largely abandoned. Since then, there has been increasing anecdotal evidence that vitamin C may still be useful as an anticancer medicine if used in high concentrations and given directly into the vein (intravenously), rather than orally. This research aimed to investigate the effects of using high doses of intravenous vitamin C on ovarian cancer to shed light on the issue.
Conclusion
Among 25 newly diagnosed ovarian cancer patients, those given vitamin C alongside standard chemotherapy were found to have significantly fewer mild to moderate treatment-related side effects than those on standard treatment. However, the researchers found no significant differences in terms of cancer survival, which was assessed up to five years after treatment. One explanation for this is that the study was too small to detect any effect, but this could also be because no survival benefit actually exists. It's also worth noting that the women knew whether they were given vitamin C, so the placebo effect may have influenced reporting of side effects. This is particularly relevant, as two participants actually withdrew from the study because they were allocated standard chemotherapy but wanted to receive vitamin C as well. This gives an indication that at least some of the participants were expecting greater benefits through receiving vitamin C. Consequently, while there are tentative signs that high-dose intravenous vitamin C may have the potential to complement existing chemotherapy treatments in treating ovarian cancer, this has not yet been proven convincingly. The conclusions that we are able to draw from this research are limited by its small sample size (just 25 people) and its sole focus on ovarian cancer, rather than a range of cancers. These points limit the reliability and generalizability of its results for all cancers at this stage. A large human clinical trial investigating the intravenous effects of vitamin C, in combination with standard chemotherapy, in a range of cancers would provide the reliability that the current study lacks. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter. Join the Healthy Evidence forum.
http://www.nhs.uk/news/2014/02February/Pages/Vitamin-C-not-proven-to-boost-chemo.aspx
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http://www.nhs.uk/news/2014/02February/Pages/Vitamin-C-not-proven-to-boost-chemo.aspx
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