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MBBS First Professional (Part-II Examination)

BIOCHEMISTRY MCQs

Maximum Marks: 35 Time Allowed: ____________

Q 1. Which of the following is a component of electron transport chain?
A. Carnitine
B. NADPH
C. CoA
D. Cytochrome c
E. ATP


Q 2. Reducing equivalents are first transferred from cytochrome b to
which electron acceptor?
A. ATP synthase
B. CoQ
C. Cytochrome c
D. Cytochrome aa3
E. Cytochrome b



Q 3. Which of the following enzymes is an enzyme of glycolysis?
A. Pyruvate carboxylase
B. Glucose-6-phosphatase
C. Phophoenolpyruvate carboxykinase
D. Phosphoglycerate kinase
E. Pyruvate dehydrogenase


Q 4. Which of the following enzymes of tricarboxylic acid (TCA) cycle
catalyzes oxidative decarboxylation?
A. Aconitase
B. Alpha-ketoglutarate dehydrogenase complex
C. Citrate synthase
D. Fumarase
E. Malate dehydrogenase


Q 5. Which of the following enzymes is deficient in Von Gierkes disease?
A. Pyruvate kinase
B. Fructose 1,6-bisphosphatase
C. Glycogen phosphorylase
D. Glucose 6-phosphatase
E. Glycogen synthase


Q 6. Glucose 6-phophate dehydrogenase catalyzes the formation of which
of the following compounds?
A. Glucose 6-phosphate
B. Ribose 5-phosphate
C. Xylulose 5phosphate
D. Glyceraldehyde 3-phosphate
E. 6-Phosphogluconate


Q 7. Which of the following is a precursor for glucose synthesis via
gluconeogenesis?
A. Fatty acid
B. Leucine
C. Glycerol
D. Cholesterol
E. Glucagon
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Q 8. By hydroxylation tyrosine is synthesized from which of the following
compounds?
A. Dopamine
B. Tryptophan
C. Phenylalanine
D. Epinephrine
E. DOPA (dihydroxyphenylalanine)


Q 9. The reaction of urea cycle in which urea is synthesized is catalyzed
by:
A. Carbamoyl phosphate synthetase I
B. Ornithine transcarbamoylase
C. Argininosuccinate synthetase
D. Arginase
E. Argininosuccinate lyase


Q 10. Phenylketonuria may result due to the deficiency of which of the
following enzymes?
A. Alanine aminotransferase
B. Serine hydroxymethyl transferase
C. Phenylalnine hydroxylase
D. Cystathionine synthase
E. Tyrosine hydroxylase


Q 11. Neurotransmitter 5-Hydroxytryptamine is derived from which of the
following amino acids?
A. Cysteine
B. Glycine
C. Methionine
D. Tryptophan
E. Tyrosine


Q 12. Which of the following amino acids is a structural component of
glutathione?
A. Aspartate
B. Tryptophan
C. Glycine
D. Glutamine
E. Methionine


Q 13. Ketone bodies cannot be utilized by liver because it lacks:
A. Thiokinase
B. Thiophorase
C. HMGCoA lyase
D. Acetyl CoA carboxylase
E. Thiolase


Q 14. Which of the following is involved for the entry of long chain fatty
acids into mitochondria through inner mitochondrial membrane?
A. Glutathione
B. Alanine
C. Carnosine
D. Carnitine
E. Creatine


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Q 15. Triacylglycerols contained in chylomicrons are hydrolyzed by which
of the following enzymes?
A. Hormone sensitive lipase
B. Lipoxygenase
C. Lipoprotein lipase
D. Cyclooxygenase
E. Phospholipase A2


Q 16. Reducing equivalents required for the de novo synthesis of fatty
acids are mainly supplied by:
A. Glycolysis
B. Tricarboxylic acid cyle
C. Fumarase
D. Hexose monophosphate pathway
E. Glutamate dehydrogenase


Q 17. Cyclooxygenase catalyzes the synthesis of which of the following
compounds?
A. Cyclic AMP
B. Leukotrienes
C. Prostaglandins
D. Cyclic GMP
E. Porphobilinogen


Q 18. Hyperuricemia is associated specifically with which of the following
disease?
A. Diabetes mellitus
B. Diabetes insipidus
C. Peptic ulcer
D. Gout
E. Hyperparathyroidism


Q 19. Synthesis of uric acid from xanthine is catalyzed by which of the
following enzymes?
A. Guanase
B. Adenosine deaminase
C. AMP deaminase
D. Xanthine oxidase
E. 5-Nucleotidase


Q 20. The deficiency of the UV-specific exonuclease may result to which of
the following disease?
A. Xerophthalmia
B. Xeroderma pigmentosum
C. Lesch-Nyhan syndrome
D. Gout
E. Orotic aciduria


Q 21. Which of the following enzymes catalyzes the formation of the final
phosphodiester linkage between 5-phosphate group on the DNA
chain synthesized by prokaryotic DNA polymerase III and the 3-
hydroxyl group on the DNA chain synthesized by DNA polymerase I?
A. Xanthine oxidase
B. DNA ligase
C. Primase
D. Phosphodiesterase
E. DNA Helicase

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Q 22. Which of the following is not involved in the initiation of protein
synthesis?
A. Ribosomal subunit
B. mRNA
C. Aminoacyl tRNA
D. ATP
E. Initiation factor


Q 23. In eukaryotes, RNA sequences which do not code for protein are
called:
A. Exons
B. Splisosomes
C. Okazaki fragments
D. Rho factor
E. Introns


Q 24. A molecule of DNA to which the fragment of DNA to be cloned is
joined is called:
A. Okazaki fragment
B. Cloning vector
C. cDNA
D. Oncogene
E. DNA probe


Q 25. A subject who has become dehydrated, body water should be
replaced by intravenous infusion of which of the following solutions?
A. 0.9% sodium chloride
B. 10% glucose solution
C. Albumin
D. 5% glucose solutions
E. Distilled water


Q 26. Metabolic alkalosis may result due to which of the following
conditions?
A. Uncontrolled diabetes mellitus
B. Aspirin poisoning
C. Severe vomiting
D. Methanol poisoning
E. Diarrhea


Q 27. Respiratory acidosis results due to the excessive accumulation of
which of the following acids?
A. Lactate
B. Beta-hyrdroxybutyrate
C. Acetoacetate
D. Carbonic acid
E. Aspartate


Q 28. Which of the following is not a peptide hormone?
A. Epinephrine
B. Erythropoietin
C. Vasopressin
D. Parathyroid hormone
E. Calcitonin


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Q 29. There are intracellular receptors for which of the following
hormones?
A. Insulin
B. Folllicle stimulating hormone (FSH)
C. Oxytocin
D. Thyroxine
E. ACTH


Q 30. What is not correct about the action of growth hormone?
A. It decreases liver glycogen store
B. It increases plasma glucose concentration
C. It increases protein synthesis
D. It causes increased uptake of amino acids by tissues
E. It has ketogenic effect


Q 31. The receptors of which of the following hormones are not associated
with G-protein?
A. Glucagon
B. TSH
C. Epinephrine
D. Vasopressin
E. Aldosterone


Q 32. cAMP activates which of the following enzymes?
A. Adenylyl cyclase
B. Tyrosine kinase
C. Phospholipase C
D. Phosphodiesterase
E. Protein kinase A


Q 33. Which of the following is not a steroid hormone?
A. ACTH
B. Aldosterone
C. Cortisol
D. Testosterone
E. Estrogen


Q 34. Which of the following is the most significant source of stored energy
in human body?
A. Liver glycogen
B. Muscle glycogen
C. Adipose tissue
D. Muscle protein
E. Liver protein


Q 35. Complete oxidation of one gram of fat in human body yields how
much energy in kcal?
A. 4
B. 9
C. 7
D. 3
E. 12