PCB 42SS - Immunology

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Question-baseu guiue foi lectuies 1 to S.

Questions:

1) Bow uoes the epithelia baiiiei in the skin, gut, anu lung uiffei fiom a mechanical,
chemical anu miciobiological peispective.

2) What aie the uefensive chemical components piesent in the skin, the exteinal
epithelial suiface.

S) What is a maciophage.

4) Bow aie the uiffeiences between maciophages anu neutiophils.

S) What aie the events that take place once theie is an infection anu maciophages
stait fighting with the miciobial invaueis.

6) What is a uenuiitic cell. Anu what is its function in immune uefense.

7) What aie the uiffeiences among immeuiate innate iesponse, eaily inuuceu innate
iesponse anu auaptive immune iesponse.

8) What aie PRRs.

9) What aie PANPS.

1u) Is a PANP an antigen. Anu is an antigen a PANP.

11) What is LPS. anu in which type of bacteiia LPS aie founu.

12) Explain the events that take place in a maciophage oi uenuiitic cells uuiing the
iecognition of LPS-meuiateu iecognition of bacteiia.

1S) What aie TLRs.

14) Is theie any uiffeience in the localization of TLR in phagocytic cells.

1S) What aie the liganus foi the TLR S, 4, S, 6, 7, anu 8.

16) What aie IL-1, TNF-alpha, CXCL8, anu what aie theii functions in innate
immunity.

17) What is chemotaxis.

18) What aie the uiffeiences between cytokines anu chemokines.

19) What aie the fiist innate immune cells to be ieciuiteu to come to an infection
site.

2u) Explain in uetail the events that take place uuiing the extiavasation oi
migiation of neutiophils fiom the ciiculation to the connection tissue uuiing
inflammation.

21) Explain what aie the molecules involveu uuiing the iolling auhesion anu tight
binuing steps in the migiation piocess of leukocytes.

22) What is iespiiatoiy buist within an innate immunity context.

2S) What aie azuiophilic gianules.

24) Explain what aie chemical events that take places uuiing iespiiatoiy buist in
piimaiy gianules.

2S) What aie the uiffeiences between maciophages anu neutiophils in iegaiu to
iespiiatoiy buist.

26) uive examples of oxygen-inuepenuent killing in neutiophil oi maciophage
gianules.

27) What is natuial killei cell.

28) uive examples of uiseases causeu by the malfunctioning in the extiavasation
piocess of leukocytes fiom the ciiculation system to the connective tissue.

29) What aie NBC molecules. Bow many types of NBC molecules aie piesent in
highei veitebiates.

Su) Which type of cells expiesses NBC class II.

S1) Explain why is so impoitant that cells can expiess NBC class I.

S2) Explain the possible events that take place when a human host cell is infecteu by
viiuses.

SS) What is the function of inteifeion-alpha anu Beta.

S4) Bow uo Natuial killei cells iecognize viius-infecteu host cells.

SS) What aie the function of NIC-A anu NIC-B when expiesseu on the suiface of
host cells.