University of Santo Tomas Faculty of Pharmacy Department of Medical Technology Syllabus for Analytical Chemistry I Lecture Second Semester

AY 2012-2013 Course Title: Course Number: Course Description: ANALYTICAL CHEMISTRY I LECTURE CHEM 301 The course deals with the concepts of qualitative and quantitative chemistry with emphasis on chemical kinetics, chemical equilibria, volumetric and instrumental methods of analysis. The course aims to provide Medical Technology students with the basic principles and concepts of analytical chemistry in preparation for their field of study. The course will expose the students to different methods of analysis, their applications and limitations, and equip the students with problem solving skills. The course will introduce a wide range of techniques useful in modern analytical chemistry. 3 units 3 lecture hours per week Chem 100 (General Inorganic Chemistry) First Year, Second Semester 1. Apply the basic principles of analytical chemistry in laboratory analyses; 2. Appreciate the importance of qualitative and quantitative analyses in the clinical laboratory; 3. Interpret the data and results of different methods of analyses FIRST (PRELIMINARY) GRADING PERIOD Specific Objectives Topics Unit 1. Introduction to Analytical Chemistry 1. Appreciate the role of analytical chemistry in the medical field and other fields of science The Role of Analytical Chemistry Qualitative Chemistry Quantitative Chemistry 3 Time Allotment (Hrs) Teaching Strategies Lecture discussion with the use of PowerPoint presentation Skills Critical thinking, Knowledgebased, Problem solving Values Evaluation/ Assessment Graded recitation Short quiz/es Chapter quiz

Course Credit: Contact Hours: Prerequisite: Placement: General Objectives:

Honesty Self-reliance Diligence Responsibility

Unit 2. Colligative Properties of Non-Electrolytes and Electrolytes 1. Solve various kinds of problems involving colligative properties of solutions Vapor Pressure Lowering Boling point elevation Freezing point depression Osmotic pressure Unit 3. Chemical Kinetics Rate Law Orders of Reaction Reaction Mechanisms Catalysis Factors Affecting Reaction Rate 3 3

Lecture discussion with the use of PowerPoint presentation; Blackboard elearning module Lecture discussion with the use of PowerPoint presentation Blackboard elearning module

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz

1. Write the rate law expression for a given reaction 2. Determine the order of a reaction from a given set of experimental data 3. Enumerate and know the significance of the factors that affect reaction rate

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz

Unit 4. Chemical Equilibrium 1. Write the equilibrium expression for any balanced chemical equation 2. Predict the shift in equilibrium based on Le Chateliers Principle 3. Evaluate the equilibrium constant, Kc or Kp, for a reaction at a particular temperature Equilibrium Constant Law of Mass Action Homogenous Equilibrium Heterogenous Equilibrium Le Chateliers Principle Factors Affecting Equilibrium Systems Lecture discussion with the use of PowerPoint presentation Blackboard elearning module Critical thinking, Knowledgebased, Technical, Analytical Graded recitation Short quiz/es Chapter quiz

Honesty Self-reliance Diligence Responsibility

Unit 5. Acid-Base Equilibria 1. Identify the Bronsted acid and base in a reaction, their conjugate pairs and relative strengths 2. Solve problems involving ionization constants, pH, pOH, and percent ionization of weak electrolytes 3. Solve problems involving buffer solutions 4. Correlate the color change of indicators with pH Concepts of Acids and Bases Strength of Acids and Bases Ion Product of Water Equilibrium of Weak Acids and Weak Bases pH and pOH Buffers Indicators 6 Lecture discussion with the use of PowerPoint presentation Blackboard elearning module

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz

5. Deduce whether a salt solution is acidic, basic or neutral

Hydrolysis 3 hrs SECOND (FINAL) GRADING PERIOD Time Allotment (Hrs) Teaching Strategies Lecture discussion with the use of PowerPoint presentation Blackboard elearning module Evaluation/ Assessment PRELIMINARY EXAMINATION

Specific Objectives

Topics Unit 6. Introduction to Chemical Analyses

Skills

Values

1. Enumerate the analytical processes employed in quantitative analysis 2. Differentiate between determinate and indeterminate errors 3. Appreciate the importance of accuracy and precision in evaluating measurements

A Typical Method of Analysis Sources and Nature of Errors Indeterminate errors Determinate errors Accuracy and Precision Unit 7. General Concepts of Titrimetric (Volumetric) Analysis 3

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz

1. Explain volumetric concepts such as titration, standardization, primary and secondary standard, indicator, equivalence point and standard solution 2. Classify different titrimetric methods

Concepts of Titration 3 Different Types of Titration Procedures Direct Titration Back/residual titration Displacement titration Unit 8. Acid-Base Titration

Lecture discussion with the use of PowerPoint presentation Blackboard elearning module

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz

1. Identify different titrants and primary standards possible for

Acid-Base (Neutralization) Titration

Lecture discussion with the use of PowerPoint

Critical thinking, Knowledgebased,

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es 3

neutralization titrations 2. Differentiate between acidimetric and alkalimetric analyses 3. Carry out calculations for acidbase titrations

presentation Acidimetric Analysis Alkalimetric Analyis Double Indicator Method (Carbonic Acid Equilibrium) Unit 9. Precipitation Reactions and Titrations Blackboard elearning module

Technical, Analytical

Chapter quiz

1. Compute for the molar solubility of slightly soluble compounds from its solubility product, and vice-versa 2. Predict the formation of precipitate by comparing the ion product, Q, to Ksp 3. Correlate the effect of pH, common ion and complex ion formation on solubility 4. Identify titrants and standards used in precipitation titration 5. Use the concepts of precipitimetry in precipitation titrations with silver nitrate using Mohr, Volhard and Fajans methods

Molar Solubility and Solubility Product Constant Predicting Precipitate Formation Fractional Precipitation Precipitation with Sulfide Factors Affecting Solubility Precipitation Titration Mohr Fajans Volhard Unit 10. Complexometric Titration Lecture discussion with the use of PowerPoint presentation Critical thinking, Knowledgebased, Technical, Analytical Graded recitation Short quiz/es Chapter quiz

Honesty Self-reliance Diligence Responsibility

1. Write the chemical formula and name coordination compounds 2. State the importance and application of coordination compounds 3. Calculate problems on complexometric titration with emphasis on EDTA titrations 1. Recognize auxiliary reagents that convert an analyte to a single oxidation state 2. Solve problems applying the concepts of redox titration

Theory of Complexes Nomenclature of Coordination Compounds Formation Constants Chelates: EDTA EDTA Titration Application to Water Hardness Unit 11. Redox Titration General Principles Auxiliary Oxidizing and Reducing Agents Permanganate Method

Lecture discussion with the use of PowerPoint presentation Blackboard elearning module Lecture discussion with the use of PowerPoint presentation

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz 4

Unit 12. Spectrophotometry 1. Interpret the process of absorption 2. Apply Beers Law to instrumental systems of analysis (UV-VIS) 3. Calculate problems on absorption spectrophotometry 1. General Principles 2. Beer-Lamberts Law 3. UV-Vis Spectrophotometry 4. Calculations In Spectrophotometry 3 hrs

Lecture discussion with the use of PowerPoint presentation Blackboard elearning module

Critical thinking, Knowledgebased, Technical, Analytical

Honesty Self-reliance Diligence Responsibility

Graded recitation Short quiz/es Chapter quiz

FINAL EXAMINATION

GRADING SYSTEM: Two grading periods: 50% first grading period 50% second grading period Each grading period consists of 40% quizzes, 50% long examinations and 10% class standing (assignments, seatwork and attendance).
COURSE REFERENCES:

Basic Readings: Extended Readings: Web Based: Instructional Media:

Whitten, K.W., R.E. Davis, M.L. Peck, G.G. Stanley. 2010. Chemistry. 9 Ed. Australia: Thomson Brooks/Cole. th Skoog, D.A., D.W. West, F.J. Holler and S.R. Crouch. 2000. Analytical Chemistry. 7 edition. Australia: Brooks/Cole th Chang, Raymond. 2010. Chemistry. 10 edition, New York: McGraw-Hill, Inc. rd Masterton, William and Hurley, Cecile.1997. Chemistry, 3 edition. Philapdelphia: Saunders College Publishing www.brookscole.com/chemistry/whitten9 www.eleap.ust.edu.ph interactive animated discussion

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Prepared by: Analytical Chemistry Group (Department of Biochemistry) (Asst. Prof. Erlinda Nuguid, Asst. Prof. Gardee Pea, Ms. Irene Liu) November 7, 2012 Approved by:

Prof. Priscilla M. Torres, Ph.D. Dean, Faculty of Pharmacy November 7, 2012