Innate Immunity

Fungi Bacteria
Mucins Anti-Microbial Molecules -Defensins Angiogenin-4 Reg3 Mucus Replenishment

Parasite Parasite

Virus
Pathogen Killing and Shedding, Barrier Function NK Cell IL-1, IL-12, IL-18, TNF- Dendritic Cell Maturation Macrophage Apoptosis IL-12 TLRs, NLRs, CLRs, Other Intracellular Receptors IFN- Antigen Presentation, Costimulation, IL-12

Mucus Replenishment

Bacteria

Th1 and Th17 Response

CXCL8 (IL-8)/KC CCL3 Neutrophil Recruitment

Larvae Control CLRs , TLRs Chitins, Proteases, Secreted Products

? ?

IL-25 IL-33 TSLP

Mucus Production Mucus Production Glycans IL-13 Larvae Control ROS/NOS

Goblet Cells

Paneth Cells Injury

TLRs, NLRs, CLRs, Other Intracellular Receptors

Macrophage Dendritic Cell Phagocytosis

Neutrophil

ROS NOS

Alternative Activated Macrophage (AAM) Arginase+, Ym-1+, RELM+ NET (Neutrophil Extracellular Trap)

Lipids

Innate Lymphoid Cell CLRs and TLRs

TLRs and FcRs

COX2 Cell Proliferation, Injury Repair Differentiation Phagosome ROS/NOS Phagosomal Digestion Pathogen Elimination Degranulation Phagosome

Eosinophils, Basophils, Mast Cells Alarmins, IL-4, TSLP

IL-13

PGE2

CCL2, 3, 5, 7 Activation TNF-, NO Inflammation, Anti-Microbial Responses

-Defensins Cathepsins Elastase Lysozyme

ROS NOS Pathogen Killing

Dendritic Cell Pathogen Containment and Damage Antigen Presentation

Macrophage Monocyte Recruitment TNF- / NO (Nitric Oxide)-Producing Cell

Innate immune mechanisms of cancer promotion

Myeloid-Derived Suppressor Cell (MDSC) Mucus Production IL-13 Injury Allergens IL-25 IL-33 TSLP Mature Dendritic Cell Tumor -Associated Macrophages (TAM)

Dendritic Cell Recruitment Dendritic Cell

Antigen Presentation and Activation of Adaptive Immunity NK Cell Activation

Regulatory Functions Modulation of Cytokine Production Dendritic Cell Maturation

Th2 Response
Virus

CCL3,4,5,20 CXCL12 Tumor Growth Inhibition IFN- v5L CD36L TRAIL-R v5 CD36 TRAIL Maturation/Activation pDC Fibroblast TNF- IFN- Activation IL-12 IL-15 IL-18 Dendritic Cell IFN- Anti-Viral Functions TLR7, 9 RLR, DNA Sensors

Other Eat Me Signals Distribution Through Sweat: Cathelicidins, Dermcidin -Defensins Innate Lymphoid Cell Maturation Eccrine Epithelial Cells Eccrine Gland Bacterial Lysis ROS, ATP IL-1, TNF- Antigen Presentation/ Costimulation IL-6 IFN- Inhibition of Tumor Proliferation

Tumor Cell Survival and Proliferation

Th2 and Th22 Response

Tumor Cells Dendritic Cell TNF-, Histamine

? TRAIL-R MULT1 MICA/B B7-H6

NKp44, 46 TRAIL NKG2D NKG2D NKp30 NK Cells Tumor Control

Antigen Presentation Antigen Presentation

NK Cell Activation

CX3CL1 NK Cell Recruitment IgE-Mediated Degranulation Perforin Granzyme B

Infected Cell Killing

Desquamation

Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

Cytotoxic T Lymphocytes

Injury Allergens
CD11c CD80 CD86 MHC II CLRs NLRs TLRs CD3CD11bCD19CD49bHuman: CD123 CD303 Mouse: B220 Ly6C CD317

Mast Cell

Tumor Killing BioLegend, Inc. 2013

CD49b CD56 CD122 CD314 (NKG2D) CD335 (NKp46) CD336 (NKp44) Classic: CD68 CD14 CLRs NLRs TLRs AAM: Arginase Ym-1 RELM Mouse: F4/80 CD3CD11b- CD45 CD11c- CD90 B220- CD127 CD49b-

CD23 CD117 CD203c FcRI

CD11b CD15 CD66c Mouse: Gr-1

TLR: Toll-like receptor NLR: NOD-like receptor CLR: C-type lectin receptor RLR: RIG-I-like receptor

biolegend.com
Interactive Poster: biolegend.com/innateimmunity
We would like to thank Dr. Ruslan M. Medzhitov of the Yale School of Medicine for his contributions to this poster.

Contact BioLegend

Dendritic Cell

Plasmacytoid Dendritic Cell (pDC)

Natural Killer (NK) Cell

Macrophage

Mast Cell

Neutrophil

Innate Lymphoid Cell

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04-0029-00