Brand Name: Augmentin

Generic Name: Amoxycillin trihydrate

Indication: Systemic infections, acute and chronic urinary tract infections caused by
susceptible strains of gram- positive and gram-negative organisms
Uncomplicated gonorrhea Endocarditis prophylaxis for dental, GI and GU
procedures, Past exposure prophylaxis to penicillin- susceptible anthrax
Drug Classification: Antibiotic (Penicillin)
Mechanism of Action: amino penicillin thatinhibits cell- wall synthesis during bacterial
multiplication. Bacteria resist amoxicillin by producing penicillinases (enzymes
that hydrolyze amoxicillin)
Dosage: Systemic infections, acute and chronic urinary tract infections caused by
susceptible strains of gram-positive and gram-negative organisms:
Adults and children weighing 20 kg (44 lb) or more: 250 to 500 mg P.O. q 8
hours. Children weighing less than 20 kg: 20 mg/kg P.O. daily in divided doses
q 8 hours; in severe infection, 40 mg/kg P.O daily in divided doses q 8 hours or
500 mg to 1 g/m2 P.O. in divided doses q 8 hours. Uncomplicated gonorrhea:
Adults and children weighing more than 45 kg (99 lb): 3 g P.O. with 1 g
probenecid given as a single dose. Children age 2 and older weighing less than
 45 kg: 50 mg/kg to a maximum of 1 g of probenecid as a single dose. Don’t
give probenecid to children younger than age 2.Endocarditis prophylaxis
for dental, GI and GU procedures: Adults: 2 g P.O. 1 hour before
procedure Post exposure prophylaxis to penicillin- susceptible anthrax: Adults
and Children older than age 9: 500 mg P.O t.i.d. for 60 days. Children
younger than age 9: 80 mg/kg daily P.O., divided t.i.d for 60 days
Special Precaution: Renal impairment, Severe hepatic dysfunction.
Pregnancy Risk Category: B
Adverse Reaction: CNS: lethargy, hallucinations, seizures, anxiety, confusion
agitation, depression, dizziness, fatigue.GI: nausea, vomiting, diarrhea ,
glossitis, stomatitis, gastritis, enterocolitis, abdominal pain, pseudomembranous
colitis, black hairy tongue GU: interstitial nephritis, nephropathy, vaginitis
Hematologic: anemia, thrombocytopenia, thrombocytopenic purpura,
eosinophilia, leukopenia, hemolytic anemia, agranulocytosis. Other:
hypersensitivity reactions, anaphylaxis, overgrowth of non susceptible
organisms.
Contraindications: Contraindicated in patients hypersensitive to drug or other
penicillins.
(continuation Augmentin)
Form: Capsules: 250 mg, 500 mg
Oral suspension: 50 mg/ml (pediatric drops), 125 mg/5ml, 200 mg/5 ml,
250 mg/5 ml, 400 mg/5ml (after reconstitution)
Tablets (film-coated): 500 mg, 875 mg
Tablets (chewable): 200 mg, 400 mg
Nursing Responsibility:
 Use cautiously in patients with other drug allergies ( especially to
cephalosporins) because of possible cross- sensitivity and in those with
mononucleosis because of high risk of maculopapular rash)
 Obtain specimen for culture and sensitivity tests before giving first dose.
Therapy may begin pending results.
 Before giving, ask patient about allergic reactions to penicillin. A negative
history of penicillin allergy is no guarantee against allergic reaction.
 If large doses are given or if therapy is prolonged, bacterial or fungal super
infection may occur, especially in elderly, debilitated, or immuno
suppressed patients.
 Drug alters results of urine glucose tests that use cupric sulfate, such as
Benedict’s reagent or Clinitest. Make Urine glucose determinations with
glucose oxidase method such as Diastix or Chemstrip uG. Ampicillin may
falsely decrease aminoglycoside levels.
 Store Trimox oral suspension in refrigerator, if possible. It also may be
stored at room temperature for up to 2 weeks. Be sure to check individual
product labels for storage information.
 Amoxicillin usually causes fewer cases of diarrhea than does ampicillin.