S KHOA HC V CNG NGH

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KHOA HC V CNG NGH
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c lp - T do - Hnh phc
TP. H Ch Minh, ngy 28 thng 05 nm 2012
K/%h &0':
- Ph1%& 2.% 34 Kh5 h6,
S0 Kh5 h6, v* C$%& %&h7
- TS89S8 N&.:;% Th< 9=%& S>?%&
- PGS8TS8 N&.:;% T@.%& T/%
T@.%& #AB Th$%& #'% Kh5 h6, v* C$%& %&h7 (C #'D% h*%h Eh !"# #h$%& #'%
,", #> 3'7. 3'+% F.5% (D% () #*' %&h'+% ,-. ~Nghin cu dt bin gen APC v
Mutyh trn bnh nhn mc bnh da polyp tuyn gia dnh G HI' h6, J K>L,
TP8HCM ,hM #@N v* TS89S8 N&.:;% Th< 9=%& S>?%& ,O%& PGS8TS8 N&.:;% T@.%&
T/% 3* ,hM %h'7B () #*'8 T@%& PhIB v' ,", %&.Q% #h$%& #'% #'DP ,R% (>L,S T@.%& #AB
Th$%& #'% ,T 4 E'D% %h> !5.:
A. KET QUA KHAO ST
N&*' ,", #*' 3'7. (C %+. #@%& Ph'D. Eh !"# #h$%& #'%S ,1% ,T ,", #*' 3'7.S %&h'+%
,-. 3'+% F.5% (D% #U%& Eh/5 ,I%h ,M5 %V' G.%& () #*'S ,W #hX:
I. NUC NGOI:
1. Sng ch:
US2011007628 Methods of killing cells and use of same in prevention and
treatment of cancerS YZ[[8
WO2011127453 Methods for diagnosis of colorectal cancerS YZ[Z8
CN101875970 Rapid detection of APC (Adenomatous Polyposis Coli) gene
mutationS YZ[Z8
US20100209426 Inhibitors of progastrin-induced repression of icat for
treating and/or preventing colorectal cancer, adenomatous polyposis or
metastasis displaying progastrin-secreting cells and cells in which the beta-
catenin/tcf-mediated transcriptional pathway is constitutively activeS YZ[Z8
EP2421520 Pharmaceutical compositions for the treatment of nasal
polyposisS YZZ\8
9M-CVKSTT-Z4 ]9H:ZY ]SH:ZZ N&*: 9H:Z[/Z^/YZ[Z T@5%& [/4
US20080031984 Compositions and methods for treating or preventing
inflammatory bowel disease, familial adenomatous polyposis and colon
cancerS YZZ^8
US8158758 Compositions and methods for treating and diagnosing cancerS
YZZ^8
2. Sch:
Genetics of colorectal cancer (cancer genetics). T", &': _h% K8 P##`@S
N@535%` M8 ]'%G@8 Nh* a.b# c%: P5P`@c5,ES YZ[Z8
Intestinal polyps and polyposis: From genetics to treatment and follow-up8
T", &': K`35'%'S TB5! SE@',E5S G'5%3.,5 C3.,,'S _h% N',h33!8 Nh* a.b#
c%: H5@G,v`@S YZZ\8
Inflammatory bowel disease and familial adenomatous polyposis: Clinical
management and patients' quality of life8 T", &': G'5% G5`#5% K`35'%'S
S8M8 G3Gc`@&8 Nh* a.b# c%: H5@G,v`@S YZZd8
3. Ti liu:
Comprehensive analysis of the bacterial content of stool from patients with
chronic pouchitis, normal pouches, or familial adenomatous polyposis
pouches8 T", &': T5%%,E G`@53G e8f ]5g3`: 935'@f M.%@ K5@`%8 N&.Q%:
Nh35BB5#@: 9g`3 K'!`5!`!S YZ[Y8
Surgical management for advanced duodenal adenomatosis and duodenal
cancer in Dutch patients with familial adenomatous polyposis: A
nationwide retrospective cohort study8 T", &': v5% H`.B`% 9i@% e8 H8f
N'`.g`%h.'! M5@@: H8f v5% G@ H5@@:8 N&.Q%: S.@&`@:S YZ[Y8
The expression of Ang-1, Ang-2 and the Tie-2 receptor in colorectal cancer
tissue and its significance8 T", &': e`% Ch.% J5%&f e5%& A' P'%&f jh5%& _'
H%&f J5% e`' jh%&8 N&.Q%: H.B5% H`53#h 5%G 9'B`G',53 k%&'%``@'%&
lHH9kmS YZ[[8
APC and its modifiers in colon cancer8 T", &': ]5g@`%,` N8 Kg%&S
e'33'5B n8 Kv`8 N&.Q%: AGv5%,`! '% kaP`@'B`%#53 M`G','%`S YZZ\8
The search for gene-gene interactions in colorectal cancer: Using HPC to
overcome computational barriers8 T", &': ,h5@'%&`@S n8f o`'GS n8f G@5h5BS
P8f T@`gS A8f T`%`!5S A8f n5@@'%&#%S S8f C5BPc`33S H8f K.%3PS M8G8 N&.Q%:
H'&h P`@h@B5%,` CBP.#5#'%53 S:!#`B! 9'3&:S YZZ\8
Familial adenomatous polyposis in children younger than age ten years: A
multidisciplinary clinic experience8 T", &': A##5@GS ThB5! MS MKS nACGf
T5i.@'S T5%:5f P`#`@!%S K@'!#'% KS 9SNf T'%3`:S S.!5%f Th@!%S A35% GS
MK8 N&.Q%: K'!`5!`! h #h` C3% p o`,#.BS YZZ^8
9M-CVKSTT-Z4 ]9H:ZY ]SH:ZZ N&*: 9H:Z[/Z^/YZ[Z T@5%& Y/4
Mutational screening of the APC gene in chilean families with familial
adenomatous polyposis: Nine novel truncating mutations8 T", &': ` 35
n.`%#`S M5@i@'` KS MS,f A3v5@`qS K5@'% PS MS,f ]`#`3'`@S A3`i5%G@ _S MS,f
9`333'S n`3'P`f A,.r5S M5@'5%5 ]S MS,8 N&.Q%: K'!`5!`! h #h` C3% p
o`,#.BS YZZs8
Do we know all there is to know about Familial Adenomatous Polyposist8
T", &': K5@'B 9.&5#`hS AhB`G K@',h`%`S o5i5 M5@@5E,h'S N5G'5 K.@G5S
J5%%',E 93%G`5. ]5h`3:S AB`3 M.!!5S e5h5 T@.G'S S5@@5 9`% _'3`%'S
T5gh'E N5ii5@S n3@`%# S.c@'`@S AB`3 9`% ABB5@ k3&55'`G8 N&.Q%:
G5!#@`%#u@3&'` C3'%'F.` `# 9'3&'F.`S YZZs8
Pre-operative endoscopic diagnosis and management of familial
adenomatous polyposis8 T", &': G'G`% S#`'%c5,h8 N&.Q%: T`,h%'F.`! '%
G5!#@'%#`!#'%53 k%G!,P:S YZZd8
Inherited polyposis syndromes: molecular mechanisms, clinicopathology,
and genetic testing8 T", &': 9@`## e8 Ka`:S S,## K8 K.g5G5S o5%G533 e8
9.@#8 N&.Q% C3'%',53 G5!#@`%#`@3&: 5%G H`P5#3&:S YZZv8
Hereditary non-polyposis colorectal cancer risk assessment based on AI
analysis of pedigree data8 T", &': KE.`@S M8f N5&.'cS o8f _5%`v'`S P8f
J.%&h.!c5%GS H898f G@``%S o8 N&.Q%: k%&'%``@'%& '% M`G','%` 5%G 9'3&:
S,'`#:S YZZ48
Effect of sulindac treatment for attenuated familial adenomatous polyposis
with a new germline APC mutation at codon 1618 T", &': k!5E'S M#h'@f
M5#!.B#S T5E5:.E'f M'q.%S M'#!.@.f Kc@'S J',h'@f J!h'B.@5S o:.i'8
N&.Q%: K'!`5!`! h #h` C3% p o`,#.BS YZZY8
The farthest 3' distal end APC mutation identified in attenuated
adenomatous polyposis coli with extracolonic manifestations8 T", &':
N5&5h'G` M5#!.c5@5S H'@!h' I!q5E'S N@'5E' T5%5E58 N&.Q%: K'!`5!`! h #h`
C3% p o`,#.BS YZZZ8
An unusually severe phenotype for familial adenomatous polyposis8 T",
&': k,,3`!-KMS ].%#-PeS e533'!-JS G@'hh'#h!-MS S5%Gh.-9S M,E5:-SS
M@#%-KS Sh`5!'B%G!-_S M5,G%53G-n8 N&.Q%: A@,h'v`! h K'!`5!` I%
Ch'3GhGS [\\s8
4. Bi bo:
Enhanced suicidal erythrocyte death in mice carrying a loss-of-function
mutation of the adenomatous polyposis coli gene8 T", &': 25G@' S:`G M8f
M5hB.G H5!5%f ]5%& k3'!5c`#h8 N&.Q%: _.@%53 h C`33.35@ A%G M3`,.35@
M`G','%`S YZ[Y8
Mutational studies of adenomatous polyposis coli gene in carcinomas
frompatients with hereditary non-polyposis colorectal cancers. T", &': H.
9M-CVKSTT-Z4 ]9H:ZY ]SH:ZZ N&*: 9H:Z[/Z^/YZ[Z T@5%& 3/4
A%&S _'5%f _'%S Sh`%-h5%&f jh5%&S Sh.-qh5%f jh`%&S Sh.8 N&.Q%: Ch'%`!`
_.@%53 h M`G',53 G`%`#',!S YZZ38
Regression of an aggressive abdominal desmoid tumor in a patient with
familial adenomatous polyposis by hyperthermoradiotherapy8 N&.Q%:
AB`@',5% _.@%53 h G5!#@`%#`@3&:S [\\s8
5. Lun n:
The psychosocial impact of familial adenomatous polyposis on adolescents:
A qualitative study8 T", &': 9@g% ]5.@5 _8 T@>w%&: J@E x%'v`@!'#:
lC5%5G5mS YZZv8
II. TRONG NUC:
1. ti nghin cu:
Nghin cu d|ch t hc, chn don, diu tr| phng chng mt s bnh ung
thu o Vit Nam (v, gan, d dy, phi, mu). ChM %&h'7B () #*': N&.:;% 9"
y-,8 C? F.5% ,hM #@N: 97%h v'7% KS YZZv8
2. Lun n:
Nghin cu dt bin gen APC o bnh ung thu di trc trng th da polyp
tuyn gia dnh8 T", &': N&.:;% Ph>?%& A%h8 T@>w%& HI' h6, J H* NV'S
YZ[[8
3. Bi bo:
Phng nga ung thu di trc trng8 T", &': ThS89S8 Vz T.:D# M5'8 N&.Q%:
ggg8#'`%Ph%&8v%S YZ[Y
Plyp dai - truc trang: chi du ung thu8 T", &': TS89S H={%& TAB8 N&.Q%:
h##P://!&##8v%S YZ[Y
Ung thu di trc trng - hu mn8 T", &': TS89S8 H| T@6%& H'8 N&.Q%:
h##P://.%&#h.8%`#8v%S YZZ\
B. CN B KHAO ST: KS8 T@}% Th< K'B M'%h ~ Ph1%& Th$%& #'% C$%& %&h7
'% #h$%& c" ED# F. Eh !"# ,M5 ,h%& #$'8
T@A% #@6%&8/8
Ni nhn:
- Nh> #@+%f
- ]>. VTS CCTTS TTCN8
GIM C
lHC E4m
T@}% Th< Th. ThM:
9M-CVKSTT-Z4 ]9H:ZY ]SH:ZZ N&*: 9H:Z[/Z^/YZ[Z T@5%& 4/4