Morphine: side-effects MORPHINE: Myosis Out of it (sedation) Respiratory depression Pneumonia (aspiration) Hypotension Infrequency (constipation, urinary retention)

Nausea Emesis Tricyclic antidepressants: members worth knowin "I have to hide, the I! is after me"" #omipramine Imipramine !mitrpty#ine $ If %ant the ne&t ' %orth (no%in), the *N*is a#so after me" *esipramine Norrtripty#ine *o&epin

!na#)esics" opioids, N+!I*s ,ar-iturates yc#ophosphamide. h#orproma/ine. ar-ama/epine *iuretic (thia/ide)

2iramune, 3anamivir, 3ovira&4

Phenobarbitone: side effects hi#dren are annoyin) (hyper(inesia, irrita-i#ity, insomnia, a))ression)4 !du#ts are dosy (sedation, di//iness, dro%siness)4

'ir-named dr$ s: $se()ir at start* middle or end means for )ir$s(: + #r$ s: !-acavir, !cyc#ovir, !mprenavir, idofovir, *enavir, Efaviren/, Indavir, Invirase, 0amvir, 1ancic#ovir, Norvir,

Thrombolytic a ents ,!": 5ro(inase +trepto(inase !#tep#ase (tP!) Narcotic anta onists 6he Narcotic !nta)onists are N!#o&one and N!#tre&one4 $ Important c#inica##y to treat narcotic overdose4 Ro$tes of entry: most rapid %ays meds.to&ins enter -ody "+tic( it, +niff it, +uc( it, +oa( it"" +tic( 7 In8ection +niff 7 inha#ation +uc( 7 in)estion +oa( 7 a-sorption

Patent ductus arteriosus" treatment " ome In and #ose the door"" INdomethacin is used to #ose P*!

Ose#tamivir, Pencic#ovir, Ritonavir, +aquinavir, 2a#acyc#ovir,

!I"#H-ind$cin dr$ s "%&#:

2iracept,

Physica# dependence "nticholiner ic side effects "9no% the !, *:+ of anticho#iner)ic side effects"" !nore&ia ,#urry vision onstipation. *ry Mouth +edation. +tasis of urine "tropine $se: tachycardia or bradycardia "! )oes %ith ,"" !tropine used c#inica##y to treat ,radycardia4 "spirin: side effects "!PIRIN: !sthma +a#icya#ism Peptic u#cer disease. Phosphory#ation;o&idation uncoup#in). PPH. P#ate#et disa))re)ation. Premature c#osure of P*! Intestina# -#ood #oss Reye:s syndrome Idiosyncracy Noise (tinnitus) Morphine: effects at m$ receptor PE"R: !!RIs: side effects !!RI: +erotonin syndrome +timu#ate N+ Reproductive disfunctions in ma#e Insomnia /arfarin: action* monitorin /ePT: ?arfarin %or(s on the e&trinsic path%ay and is monitored -y P64 Propranolol and related 0-olol0 dr$ s: usa)e"o#o#" is 8ust t%o -ac(%ards #o%er case -:s4 ,ac(%ard -:s stand for "-eta -#oc(er"4 $ ,eta -#oc(ers inc#ude ace-uto#o#, -eta&o#o#, -isopro#o#, o&preno#o#, proprano#o#4 #epression: 1 dr$ s ca$sin it PROM!: onfusion Euphoria !na#)esia Respiratory depression %eta-- )s %eta-. receptor #ocation "<ou have = heart and > #un)s"" ,eta;= are therefore primari#y on heart4 ,eta;> primari#y on #un)s4 Proprano#o# Reserpine Ora# contraceptives Methy#dopa +teroids 2ead poisonin : presentation "%&#E34: !nemia ,asophi#ic strippin) o#ic(y pain *iarrhea Encepha#opathy 0oot drop 1um (#ead #ine) &holiner ics 5e or anophosphates6: effects If you (no% these, you %i## -e "@E++ *5M,"" @acrimation E&citation of nicotinic synapses +a#ivation +%eatin) *iarrhea 5rination Micturition

,ronchoconstriction %en7odia7epines: actions ",en + !Ms Pam into seduction not -y -rain -ut -y musc#e"" +edation anti; onvu#sant anti;!n&iety Musc#e re#a&ant Not -y -rain" No antipsychotic activity4

+pirono#actone imetidine Oestro)ens +ti#-oestro# !teps in the N$rsin Process !*PIE (! *e#icious PIE) Osmotic di$retics: members 4,M: 1#ycero# 5rea Mannito# "ntibiotics contraindicated d$rin pre nancy M&"T: Metronida/o#e h#oramphenico# !mino)#ycoside 6etracyc#ine 2ithi$m: side effects 2ITH: @eu(ocytosis Insipidus Adia-etes insipidus, tied to po#yuriaB 6remor. 6erato)enesis Hypothyroidism !;ssessment *; ia)nosis P;#annin) I;mp#ementation E;va#uaton Inflammation 5HIPER6 H;eat I;nduration P;ain E;dema R;edness

Terato enic dr$ s (/8 TER"TO enic(: ?arfarin 6ha#idomide Epileptic dr$ s: phenytoin, va#proate, car-ama/epine Retinoid ! E inhi-itor 6hird e#ement" #ithium O P and other hormones (e) dana/o#)

"cid-%ase 5ROME6 R;espiratory O;pposite M;eta-o#ic E;qua#

4ynaecomastia-ca$sin dr$ s #I!&O!: *i)o&in Isonia/id

&"N&ER0! Early /arnin !i ns !56ION 5P

;han)e in -o%e# or -#adder !; #esion that does not hea# 5;nusua# -#eedin) or dischar)e 6;hic(enin) or #ump in -reast or e#se%here I;ndi)estion or difficu#ty s%a##o%in) O;-vious chan)es in %art or mo#e N;a))in) cou)h or persisten hoarseness 5;ne&p#ained %ei)ht #oss P;ernicious !nemia

R;est#ess E;&cessive Hun)er *;iaphoresis. *epression

I; nta(e and Output (I C O) 5; rine Output R;esponse of ,P E;#ectro#ytes

"drenal 4land Hormones 5!!!6 +;u)ar (1#ucocorticoids) +;a#t (Minera#corticoids) +;e& (!ndro)ens) P$lmonary Edema 5M"# #O46 M;Morphine !;!minophy##ine *; *i)ita#is *;*iuretics (@asi&)

6;a(e Pu#ses I;schemic Episodes (6I!) ;omp#ications" D :s

9 &0s of Hypertension ( omp#ications) ; oronary !rtery *isease ; oronary Rheumatic 0ever ; on)estive Heart 0ai#ure ; ardio 2ascu#ar !ccident

&"N&ER Inter)entions ;omfort !;#tered ,ody Ima)e N;utrition ;hemotherapy E;va#uate response to meds R;espite for careta(ers Hypo lycemia 5TIRE#6 ; an a-norma# decrease of -#ood in the su)ar 6;achycardia I;rrita-i#ity

O; O&y)en 1; ases (,#ood 1ases !,1:s) 1 P0s of &irc$latory &hecks P;Pain P;Paresthesia P;Para#ysis P;Pu#se P;Pa##or (Pa#eness) Hypertension N$rsin &are 5#I,RETI&6 *;ai#y ?ei)ht

&omplications of Tra$ma #ient (6R!5M!6I ) 6;issue Perfusion Pro-#ems R;espiratory Pro-#ems !;n&iety 5;nsta-#e #ottin) 0actors

M;a#nutrition !;#tered ,ody Ima)e 6;hrom-oem-o#ism

I;nfection ;opin) Pro-#ems rania# Nerve Mnemonic E>

! ; !rmy 1 ; 1uards 2 ; 2i##a)es ! ; !nd O; Oh H ; Huts O; Oh O; Oh 6; 6o 6; 6ouch !; !nd 0 ; 0ee# + ; +ome + ; +ays M; Mari#yn M; Monroe , ; ,ut M; My ,; ,rother +; +ays rania# Nerve Mnemonic E' ,; ,rid)et , ; ,ardot O; On O ;O#d O; O-ando 6; 6o%er 6; 6op !; 0; 0i#ipino +; +ome rania# Nerve Mnemonics E> (+ensory, Motor or ,oth) M; Mmm M; Mmm rania# Nerve Mnemonics (+ensory, Motor or ,oth)

&yanotic #efects: 9 T0s

6; 6etra#o)y of 0a##ot 6; 6runcus !rteriosus 6; 6ransportation of the 1reat 2esse#s 6; 6ricuspid !tresia

rania# Nerve Mnemonic E=

! 1 ; ir#:s 2 ; a)ina

O;@ympic (O#factory) O;Pium (Optic) O; cupies (Ocu#omotor) 6;ROu-#ed (6roch#ear) 6;RIath#etes (6ri)emina#) !;fter (!-ducens) 0;inishin) (0acia#) 2;E)as (2esti-u#ococh#ear) 1;am-#in) (1#ossopharyn)ea#) 2;!cations (2a)us) +;ti## (+pina# !ccessory) H;i)h (Hypo)#ossa#)

+ ; +o H; Heaven#y

+; +ay M ; Marry M; Money ,; ,ut M; My , ; ,rother +; +ays ,; ,ad ,; ,usiness M ; Marry M ; Money N$rsin &are for !prains and !trains 5RI&E6 R; Rest I ; Ice ; ompression

I ; Increase f#uide inta(e O ; Overhead trape/e N ; No %ei)hts on -ed or f#oor

E ; Estrio# @eve#

O% Non-!tress Test 5NNN6 ' ne)atives in a ro% to interpret resu#ts of Non; +tress 6est N ; Non;reactive N ; Non; +tress is N ; Not )ood

E)al$tion of Episiotomy Healin 5REE#"6 R; Redness E; Edema E ; Ecchymosis * ; *ischar)e, *raina)e ! ; !ppro&imation

!e)ere Pre-Eclampsia 5HE22P6 H; emo#ysis E; #evated @; iver function tests @; o%

Post-Part$m "ssessment 5%,%%2E6 ,;reasts 5;terus ,;o%e#s ,;#adder @;ochia E;pisiotomy.#ateration. ; section incision

E; E#evation

&are of &lient in Traction 5TR"&TION6 6; 6emperature (E&tremity, Infection) R ; Ropes han) free#y ! ; !#i)nment ; ircu#ation P:s) hec( (F

P; #ate#et count

"ssessment Tests for 3etal /ell-%ein 5"2ONE6 !; !mniocentesis @; @.+ Ratio O ; O&ytocin 6est N ; Non;+tress 6est

Tracheal Esopha eal 3ist$la 5: &0s6 ; ; ; ho(in) ou)hin) yanosis

6; 6ype C @ocation of fracture

I"#2! 5Instr$mental "cti)ities of #aily 2i)in 6 !&,M &left 2ip - Post Op &are 5&2E3T 2IP6 ;ho(in) @;ie on -ac( E;va#uate !ir%ay 0;eed +#o%#y 6;eachin) +;hoppin) ;oo(in) and #eanin) 5;sin) te#ephone or transportaiton M;ana)in) money and medications

?anderin) ?i#ma:s !#%ays @ate

?; ?a#(er ?; ?ith !; !ffected @ ; @e)

&ommon &a$ses of Transient Incontinence 5#I"PPER!6

@;ar)er nipp#e openin) I;ncidence incerase in ma#es P;revent crust formation and aspiration

%leedin Preca$tions 5R"N#I6 R; Ra/or E#ectric. ,#ades !; !spirin N; No need#es (esp4 in sma## )au)e) *; *o decrease in need#e stic(s) I ; In8ury (Protect from) *;e#irium I;nfection !;trophic 5rethra P;harmaceutica#s P;sycho#o)ic E;&cess 5rine Output R;estricted Mo-i#ity &anes and /alkers 5&O"26 ; ane +;too# Impaction

"#2s 5"cti)ity of #aily 2i)in 6 ,!66E*

,;athin) !;m-u#ation 6;oi#etin) 6;ransfers E;atin) *;ressin)

O; Opposite !; !ffected @; @e)

Promotion of Normal Elimination 5POOPER !&OOP6

P;osition O;utput

&anes and /alkers 5//"26

O;ffer 0#uids

P;rivacy E;&ercise R;eport Resu#ts Tra$ma !$r ery 5"MP2E6 after initial assessment +;i/e (!mount) ;onsistency O;ccu#t ,#ood O;dor P;erista#sis !;##er)ies M;edications P;ast Medica# History @;ast Mea# E;vents +urroundin) In8ury !erio$s &omplications of Oral %irth &ontrol Pills 5"&HE!6 !; !-domina# Pain ; hest Pain T#&I 5These #r$ s &an Interact6 6 ; 6heophy#ine * ; *i#antin ; oumadin

I ; #osone (Erythromycin)

Emer ency Tra$ma "ssessment 5"%&#E34HI6

; P0s of #yspnea P; Pu#monary ,ronchia# onstriction P; Possi-#e 0orei)n ,ody

H ; Headache E ; Eye Pro-#ems + ; +evere @e) Pain

!;ir%ay ,;reathin) ;ircu#ation *;isa-i#ity E;&amine 0;ahrenheit 1;et 2ita#s H;ead to 6oe !ssessment I;ntervention

P; Pu#monary Em-o#us P; Pneumothora& P; Pump 0ai#ure P; Pneumonia

Emer ency #r$ s to 2E"N on @; @idocaine

2idocaine To<icity 5!"M!6 +;#urred +peech !;#tered entra# Nervous +ystem M;usc#e 6%itchin) +;ei/ures

E ; Epinephrine !; !tropine +u#fate N ; Narcan #r$ s for %radycardia = low %P 5I#E"6 I ; Isoprotereno# * ; *opamine E ; Epinephrine

! ; !tropine +u#fate &holiner ic &risis 5!2,#6 +;a#ivation @;acrimation 5;rination *;efecation

!;phasia

I ; Intensity (GE;HEI of Ma&ima# Heart Rate) 6; 6ime (!ero-ic !ctivity) !ymptoms of Hypo<ia 5R"T %E#6 Ear#y Hypo&ia" R;est#essness !;n&iety 6;achycardia. 6achypnea

Ma>or !ymptoms of a Manic "ttack 5#I4 3"!T6 *; *istracti-i#ity I ; Indiscretion 1 ; 1randiosity 0; 0#i)ht of Ideas

#epression "ssessment 5!I46 +;#eep *istur-ances I;nterest *ecreased 1;ui#ty 0ee#in)s

!; !ctivity Increase +; +#eep *eficit 6 ; 6a#(ative

2ate Hypo<ia: ,;radycardia

: P0s of %lindness P; Preventa-#e

E;&treme Rest#essness *;yspnea

Ener y #ecreased 5&"P!6 ;oncentration decreased !;ppetite P;sychomotor function decreased +;uicida# Ideations

P; Pain#ess P; Permanent !ymptoms of Hypo<ia 5in Pediatrics6 - 3INE! 0;eedin) difficu#ty !ymptoms of 2e$kemia 5"NT6 !; !nemia N; Neutropenia I;nspiratory +tridor N;ares 0#ares E;&piratory 1runtin) +;terna# Retractions

1 "0s to "l7heimer #ia nosis !;mnesia !;nomia !;pra&ia !;)nosia

6; 6hrom-ocytopenia

E<ercise 4$ide for #iabetic 3itness 53IT6 0 ; 0requency ('& per %ee()

Mana ement of "!THM"

!;drener)ics (!#-utero#) +;teroids 6;heophy##ine

H;ydration (I2) M;as( (O&y)en) !;nti-iotics

M; Morphine O; O&y)en N; Nitro)#ycerine !; !+!

E;motiona# disorders N;euro#o)ic disorders 6;umors and trauma I;nfection !;rteriovascu#ar disease

Epi lottitis 5"IR R"I#6 Treatin &H3 5,N2O"# 3"!T6

!;ir%ay

#osed

I;ncreased Pu#se R;est#essness 5;pri)ht Position N;itrates (in #o% dose) R;etractions !;n&iety Increased I;nspiratory +tridor *;roo#in) @;asi& O;&y)en !;minophy##ine *;i)o&in

Osteoporosis Risk 3actors 5"&&E!!6

!;#coho# 5se ;orticosteroid 5se ;a#cium #o% E;stro)en #o% +;mo(in) +;edentary #ifesty#e.s

%lood 3low Thro$ h the &ardiac 'al)es 5Tiss$e Paper My "ssets6

0;#uids (decrease) !;fter#oad (decrease) +;odium restriction 6;est (*i) #eve#, !,1s, 9 #eve#)

/ho needs dialysis? 5&heck the )owels: "EIO,6 !; !cid;,ase Pro-#ems E; E#ectro#yte Pro-#ems I; Into&ications

6;ricuspid P;u#monic M;itria# !;ortic

#EMENTI" Ma(e sure they don:t have pro-#ems %ith" *;ru) and a#coho# E;yes and ears M;eta-o#ic and endocrine disorders

O; Over#oad of f#uids 5 ; 5remic +ymptoms

Immediate Treatment of a Myocardial Infarction &lient 5MON"6

Prostate Problems are no@@@ 3,N 0; 0requency

5; 5r)ency N; Nocturia

P; Po#ydypsia (e&cessive thirst) P; Po#ypha)ia (e&cessive hun)er)

N; Nitrates (Nitro)#ycerin) !; !spirin (!+!) 6; 6horm-o#ytics !; !nti; oa)u#ants +; +too# +ofteners

%R"T #iet 5for se)ere dehydration6 ,; ,anana R; Rice !; !pp#e 6; 6oasted ,read

Ri ht-!ided Heart 3ail$re 5HE"#6 H; Hepatome)a#y E; Edema (,ipeda#) !; !scites *; *istended Nec( 2ein

Electrolytes - PI!O P; Potassium I; Inside +; +odium

4l$ten 3ree #iet 5RO/6 R; Rye O; Oats ?; ?heat

2eft-!ided Heart 3ail$re 5&HOP6 ; ou)h

O; Outside

H; Hemoptysis O; Orthopnea

Eatin #isorder: "NORECI" !;menorrhea de#ayed N;o or)anic factors accounts for %ei)ht #oss O;-vious#y thin -ut fee#s 0!6 R;efusa# to maintain norma# -ody %ei)ht E;pi)astric discomfort is common K;symptoms (pecu#iar symptoms) I;ntense fears of )ainin) %ei)ht !;#%ays thin(in) of foods

"ssess &han es in !enile #ementia 5A"M&O6 J; Jud)ment !; !ffect M; Memory ; o)nition

P; Pu#monary on)estion (crac(#es. ra#es) Hyperkalemia Mana ement 5BIN#6 9; 9aye&a#ate (ora##y. enema) I; Insu#in N; Na H O' *; *iuretics (0urosemide C 6hia/ides) Mana ement of Myocardial Infarction 5MON"T"!6 M; Morphine O; O&y)en

O; Orientation

: P0s of #iabetes Mellit$s - Type - !i ns = !ymptoms P; Po#yuria (e&cessive urination)

Eatin #isorder: %,2IMI" ,;in)e eatin) 5;nder strict dietin) @;ac(s contro# over;eatin) I;nduced vomitin) M;inimum of to -in)e eatin) episodes I;ncrease.Persistent concern of -ody si/e.shape !;-use of diuretics C #a&atives

,; ,rain *ama)e !; !#coho#ic Ha##ucinosis *; *eath

@;o% se#f;esteem *;epression

!;pathy, no emotion 1 #0s of %eha)ioral Problems of "lcoholism *; *enia# *; *ependency *; *emandin) *; *estructive *; *omineerin) ,;ruised 5;nusua# in8uries +;erious in8uries E;vidence of o#d in8uries not reported

3indin s of a %$limia client: /"!HE# ?;ei)ht #oss of =FI of ori)ina# -ody %ei)ht !;menorrhea +;ocia# %ithdra%a# H;istory of hi)h activity C achievement E;#ectro#yte Im-a#ance *;epression. *istorted ,ody Ima)e

!it$ations reD$irin &risis !it$ation: R"PE R; Ruth#ess !; !-usive P; Persona# E; E&perience /arnin !i ns of a &hild "b$se8 Ne lect: &HI2# "%,!E ;hi#d:s e&cessive (no%#ed)e on se& C a-usive %ords H;air )ro%th in various #en)ths

O$tcome of "lcoholism: %"#

I;nconsistent stories from the chi#d C parent.s

P$lmonary infiltrations ind$cin dr$ s (4o %"N MeE(: 1o#d ,#eomycin. ,usu#phan. , N5 !miodarone. !cyc#ovir. !/athioprine Nitrofurantoin Me#pha#an. Methotre&ate. Methyser)ide

ataracts 5#cers +(in" striae, thinnin), -ruisin) Hypertension. Hirsutism. Hyper)#ycemia Infections Necrosis, avascu#ar necrosis of the femora# head 1#ycosuria

MPTP: mechanism* effect MPTP: Osteoporosis, o-esity Mitochondria# Par(inson:s;6ype Poison4 Immunosuppression L ! mitochondria# poison that e#icits a Par(inson:s;type effect4 *ia-etes

"ntim$scarinics: members* action "Inhi-its Parasympathetic !nd +%eat"" Ipratropium Piren/epine !tropine +copo#amine L Muscarinic receptors at a## parasympathetic endin)s s%eat )#ands in sympathetic4

%eta blockers with &FP.#; polymorphic metabolism "I Met 6im arver, the meta-o#ic po#ymorph"" L 6he fo##o%in) -eta -#oc(ers require dose ad8ustment due to <P>*G po#ymorphic meta-o#ism" Metopro#o# 6imo#o# arvedi#o# (in patients %ith #o%er or hi)her than norma# <P>*G activity)

Terato enic dr$ s: ma>or non-antibiotics T"P &"P: 6ha#idomide !ndro)ens Pro)estins orticosteroids !spirin C indomethacin Phenytoin %eta blockers with intrinsic sympathomimetic acti)ity Picture dia-etic and asthmatic (ids ridin) a%ay on a cart that ro##s on pin%hee#s4 Pindo#o# and arteo#o# have hi)h and moderate I+! respective#y, ma(in) them accepta-#e for use in some dia-etics or asthmatics despite the fact that they are non;se#etive -eta -#oc(ers4 !teroid side effects &,!HIN4OI#:

M$scarinic effects !2,4 %"M: +a#ivation. +ecretions. +%eatin) @acrimation 5rination

Muino#ones Aand 0#uoroquino#onesB" mechanism "6opp#e the Mueen"" Muino#one interferes %ith 6opoisomerase II4

%eta blockers: 1astrointestina# upset ,= se#ective vs4 ,=;,> non;se#ective ,radycardia. ,ronchoconstriction. ,o%e# movement !-domina# cramps. !nore&ia Miosis O throu)h 3" ,=, ,> non;se#ective" Pindo#o#, Propana#o#, 6imo#o#4 ! throu)h N" ,= se#ective" !ce-uta#o#, !teno#o#, Esmo#o#, Metopro#o#4

G !$lfonamide side effects: +teven;Johnson syndrome +(in rash +o#u-i#ity #o% (causes crysta##uria) !er$m alb$min displaced 5ca$ses newborn kernicter$s and potentiation of other ser$m alb$min-binders like warfarin6

Riba)irin: indications RI%")irin: R+2 Inf#uen/a , !renaviruses (@assa, ,o#ivian, etc4) Hypertension" treatment !, *" ! E inhi-itors. !n)II anta)onists (sometimes !#pha a)onists a#so) ,eta -#oc(ers a#cium anta)onists *iuretics Narcotics: side effects (!&R"M if yo$ see a dr$ dealer(: !yner istic &N! depression with other dr$ s onstipation Respiratory depression !ddiction Miosis

Epilepsy types* dr$ s of choice: "Mi#itary 1enera# !ttac(ed ?eary 0i)hters Pronouncin) :2eni 2edi 2eci: !fter rushin) Enemies"" L Epi#epsy types" Myoc#onic 1rand ma# !tonic ?est syndrome 0oca# Petit ma# (a-sence) L Respective dru)s" 2a#proate 2a#proate 2a#proate ! 6H ar-ama/epine Ethosu&imide

!e< hormone dr$ s: male (3eminine Males Need Testosterone(: 0#uo&ymesterone Methy#testosterone !nti-iotics (-ia&in, penici##in, ciprof#o&acin) Nandro#one ardiac dru)s (di)o&in, #idocaine) 6estosterone 5rinary incontinence dru)s (anticho#iner)ics) &aHH channel blockers: $ses &"HH M"!H: ere-ra# vasospasm. H0 orticosteroids !n)ina H> -#oc(ers Mi)ranes !ntipar(insonian dru)s !tria# f#utter, fi-ri##ation Narcotics (esp4 mepridine) +upraventricu#ar tachycardia 1eriatric psychiatric dru)s Hypertension EN6 dru)s G "lternati)ely: (&H"!M(: Insomnia dru)s erer-ra# vasospasm . H0 N+!I*s (e) indomethacin, napro&in) Hypertension Musc#e re#a&ants !n)ina +ei/ure medicines +uprventricu#ar tachyarrhythmia Mi)ranes Therape$tic dosa e: to<icity )al$es for most commonly monitored medications "6he ma)ic >s"" #is$lfiram-like reaction ind$cin dr$ s (PM PMT( as in Pre Medical Test in the PM: Procar-a/ine Metronida/o#e efo (Pera/one, Mando#e, 6etan)4 *i)ita#is (4F;=4F) 6o&icity 7 >4 @ithium (4G;=4>) 6o&icity 7 >4 6heophy##ine (=E;>E) 6o&icity 7 >E4 *i#antin (=E;>E) 6o&icity 7 >E4 !P!P (=;'E) 6o&icity 7 >EE4 6heophy##ine Ethano# *e#erium;causin) dru)s ! 56E H!N1E IN M+"

L In order of c#ass I to I2" #i$retics: thia/ides" indications " HI thia/ides"" H0 a#cium channe# -#oc(ers Hypertension Insipidous a#cium ca#cu#i Opiods: m$ receptor effects (M# &"RE!(: Miosis Mi raine: prophyla<is dr$ s "2ery 2o#ati#e Pharmacotherapeutic !)ents 0or Mi)raine Prophy#a&is"" 2erpami# Respiratory depression 2a#proic acid Euphoria Pi/otifen +edation !mitripty#ine 0#unari/ine Methyser)ide ,#eomycin Proprano#o# isp#astin *actinomycin. *o&oru-icin "drenoceptors: )asomotor f$nction of alpha )s@ beta !, *" !#pha 7 onstrict4 ,eta 7 *i#ate4 ,usu#fan" features !, *E0" "ntiarrhythmics: classification !#(y#atin) a)ent I to I2 M,! o##e)e Etoposide 0#utamide and other steroids or their anta)onists (e) tamo&ifen, #eupro#ide) &ancer dr$ s: time of action between #N"-ImRN" "%&#E3: "lkylatin a ents *ependency onstipation !na#)esics to use Mem-rane sta-i#i/ers (c#ass I) ,eta -#oc(ers !ction potentia# %idenin) a)ents

,one marro% suppression s.e M@ indication *ar( s(in (hyperpi)mentation) s.e

" ome In and #ose the door"" INdomethacin is used to #ose P*!4

Physosti mine )s@ neosti mine 2MNOP: Endrocrine insufficiency (adrena#) s.e @ipid so#u-#e 0i-rosis (pu#monary) s.e Miotic Natura# Tricyclic antidepressants: members worth knowin "I have to hide, the I! is after me"" #omipramine Imipramine !mitrpty#ine L If %ant the ne&t ' %orth (no%in), the *N*is a#so after me" *esipramine Norrtripty#ine *o&epin +ynthetic Poor ora# a-sorption 6orsades de Pointes" dru)s causin) !P! HE" !miodarone Procainamide !rsenium isapride Ha#operido# Eritromycin %eta - selecti)e blockers ",E!M ONE up, +cotty"" ,eta = -#oc(ers" !erotonin syndrome: components &a$ses H"RM: Hyperthermia !utonomic insta-i#ity (de#irium) Ri)idity Myoc#onus Esmo#o# !teno#o# Metropo#o# 6etracyc#ine" terato)enicity 6Etracyc#ine is a 6Erato)en that causes stainin) of 6Eeth in the ne%-orn4 "ntirhe$matic a ents 5disease modifyin 6: members H!MP" yc#ophosphamide Hydro&yc#oroquine and cho#oroquinine Patent ductus arteriosus" treatment !uranofin and other )o#d compounds Ora##y a-sor-ed %e## Physosti)mine G Neosti mine* on the contrary* is: ?ater so#u-#e 5sed in myesthenia )ravis

Methotre&ate Penici##amine !uranofin, aurothio)#ucose" cate)ory and indication !urum is #atin for ")o#d" ()o#d:s chemica# sym-o# is !u)4 1eneric !ur; dru)s (!uranofin, !urothio)#ucose) are )o#d compounds4 L If didn:t #earn yet that )o#d:s indication is rheumatoid arthritis, !5R; !cts 5pon Rheumatoid4

!na#)esics" opioids, N+!I*s ,ar-iturates yc#ophosphamide. ar-ama/epine *iuretic (thia/ide) h#orproma/ine.

BH increasin a ents B-%"NB: 9;sparin) diuretic ,eta -#oc(er ! EI N+!I*

"ntiarrhythmics: class III members %I"!: ,rety#ium I-uti#ide !miodarone +ota#o#

9 supp#ement

Reserpine action: Reserpine dep#etes the Reserves of catecho#amines Aand serotoninB4 !$ccinylcholine:

M"OIs: indications M"OI0!: Me#ancho#ic Ac#assic name for atypica# depressionB !n&iety O-esity disorders Aanore&ia, -u#emiaB Ima)ined i##nesses AhypochondriaB +ocia# pho-ias L @isted in decreasin) order of importance4 L Note M!OI is inside Me#!nchO#Ic4 !I"#H-ind$cin dr$ s "%&#: %eta-blockers: side effects (%%& 2oses 'iewers In Rochedale(: %radycardia ,ronchoconstriction #audication @ipids 2ivid dreams C ni)htmares ;ve Inotropic action action, use +ucciny#cho#ine )ets +tuc( to !ch receptor, then +uc(s ions in throu)h open pore4 <ou +uc( stuff in throu)h a mouth;tu-e, and dru) is used for intu-ation4

Reduced sensitivity to hypo)#ycaemia &isplatin: ma>or side effect* action (&i!plat-In(: Ma8or side effect" +p#at (vomitin) sound);; vomitin) so severe that anti;nausea dru) needed4 !ction" 1oes Into the *N! strand4 Pra/ocin" usa)e Nysta)mus Pra/ocin sounds #i(e an acronym of "pras// /our urine"4 6herefore Pra/ocin used for urinary retention in ,PH4 <e##o%;-ro%nin) of s(in 6erato)enicity Osteoma#acia Opioids: effects %"# "MERI&"N!: ,radycardia C hypotension !nore&ia Narcotic anta onists *iminished pupi#ary si/e !na#)esics Miosis Euphoria Respiratory depression Increased smooth musc#e activity (-i#iary tract constriction) onstipation !me#iorate cou)h ref#e& Nausea and vomitin) Isoprotereno# +edation Norepinephrine T%: antibiotics $sed !TRIPE: +6reptomycin Rifampicin Isonia/id Pyri/inamide Etham-uto# Epinephrine *o-utamine #irect sympathomimetic catecholamines #INE#: *opamine 6he Narcotic !nta)onists are N!#o&one and N!#tre&one4 L Important c#inica##y to treat narcotic overdose4 "sthma dr$ s: inhibitor action /!fir#u(ast" !nta)onist of @6 /I#ueton" Inhi-itor of F;@O Interference %ith ,=> meta-o#ism (hence anemia) Neuropathies" verti)o, ata&ia, and headache Phenytoin: ad)erse effects PHENFTOIN: P;DFE interactions Hirsutism En#ar)ed )ums

"nticholiner ic side effects (Bnow the "%&#0! of anticholiner ic side effects(: !nore&ia ,#urry vision onstipation. *ry Mouth +edation. +tasis of urine 'i abatrin: mechanism 'i-4"%"-Tr-In: 2ia 1!,! 6ransferase Inhi-ition "tropine $se: tachycardia or bradycardia "! )oes %ith ,"" !tropine used c#inica##y to treat ,radycardia4 Eno<aprin 5prototype low molec$lar wei ht heparin6: action, monitorin) EnoKaprin on#y acts on factor Ka4 Monitor Ka concentration, rather than !P664 Ipratropium" action !tropine is -uried in the midd#e" ipr!tropium, so it -ehaves #i(e !tropine4 %leomycin: action ",#eo;Mycin ,#o%s My *N! to -its"" ,#eomycin %or(s -y fra)mentin) *N! (-#o%in) it to -its)4 My *N! si)na#s that its used for cancer (tar)etin) se#f ce##s)4 "spirin: side effects "!PIRIN: !sthma +a#icya#ism Peptic u#cer disease. Phosphory#ation; o&idation uncoup#in). PPH. P#ate#et disa))re)ation. Premature c#osure of P*! Intestina# -#ood #oss Reye:s syndrome Idiosyncracy Noise (tinnitus) Myasthenia ra)is: edrophoni$m )s@ pyridosti mine e*rophonium is for *ia)nosis4 pyRI*osti)mine is to )et RI* of symptoms4 Inhalation anesthetics !HINE: +evof#urane Ha#othane Isof#urane Nitrous o&ide Enf#urane L If %ant the defunct Metho&yf#urane too, ma(e it Moon+HINE4 onfusion 2$p$s: dr$ s ind$cin it HIP: Hydra#a/ine INH Procanimide

%en7odia7apines: ones not metaboli7ed by the li)er 5safe to $se in li)er fail$re6 2OT: @ora/epam O&a/epam 6ema/epam %ot$lism to<in: action* related b$n aroto<in "ction: (%ot$lism %ottles $p the "ch so it can0t be the released(: Re#ated -un)aroto&in" ",otu#ism is re#ated to ,eta ,un)aroto&in (-eta;, not a#pha; -un)aroto&in;;a#pha has different mechanism)4

9-"minopyradine 59-"P6 $se(9-"P is 3or "P(: 0or !P (action potentia#) propa)ation in Mu#tip#e +c#erosis4

Osmotic diuretics" mem-ers 15M" 1#ycero# 5rea Mannito#

%en7odia7epenes: dr$ s which decrease their metabolism "I:m Over#y a#m""

!odi$m )alproate: side effects '"2PRO"TE: 2omitin) !#opecia

Isonia/id @iver to&icity Ora# contraceptive pi##s Pancreatitis. Pancytopenia imetidine Retention of fats (%ei)ht )ain) L 6hese dru)s increase ca#min) effect of ,3*s -y retardin) meta-o#ism4 Oedema (periphera# oedema) !ppetite increase "nesthesia: 9 sta es ("nesthesiolo ists En>oy ! = M(: !na#)esia E&citement +ur)ica# anesthesia Medu##ary para#ysis Nitrof$rantoin: ma>or side effects Nitro3$r"ntoin: Neuropathy (periphera# neuropathy) 0i-rosis (pu#monary fi-rosis) !nemia (hemo#ytic anemia) 6remor En/yme inducer (#iver)

Moonface 3afir#u(ast, Monte#u(ast, ina#u(ast" Euphoria mechanism, usa)e"3afir;#u(;ast, Monte;#u(; ast, ina;#u(;ast"" L !nti;@u(otrienes for !sthma4 L *a//#e your ora# e&aminer" 3afir#u(ast anta)oni/es #eu(otriene;D4 3ero order (inetics dru)s (most common ones) "PE!3 (sounds #i(e pees) out a constant amount"" Phenytoin Ethano# !spirin 3ero order L +omeone that pees out a constant amount descri-es /ero order (inetics (a#%ays the same amount out) Hepatic necrosis: dr$ s ca$sin focal to massi)e necrosis "2ery !n)ry Hepatocytes"" 2a#proic acid !cetaminophen Monoamine o&idase inhi-itors" Ha#othane Mem-ers "PI6 of despair"" !teroids: side effects %E&2OMETH"!ONE: ,uffa#o hump 6rany#cypromine L Easy -ruisin) ataracts @ar)er appetite O-esity /arfarin: metabolism !2O/: ! pit of despair, since M!Os treat depression Phene#/ine Isocar-o&a/id Periphera# conversion of 6D to 6' is inhi-ited ;N hypothyroidism 6hin arms C #e)s Hypertension. Hyper)#ycaemia !vascu#ar necrosis of femora# head +(in thinnin) Osteoporosis Ne)ative nitro)en -a#ance Emotiona# #ia-i#ity "miodarone: action* side effects ; P0s: Pro#on)s action potentia# duration Photosensitivity Pi)mentation of s(in Periphera# neuropathy Pu#monary a#veo#itis and fi-rosis

L Has a s#o% onset of action4 L ! quic9 2itamin 9 anta)onist, thou)h4

Headache. Hepatoto&icity ps<co#o)ica# upset @actation in fema#e

+ma## #ipid;so#u-#e mo#ecu#e *ry mouth @iver" site of action Oedema Oral ro$te of administration@ Par(insonism ?arfarin !naemia (haemo#ytic)

Propythiouraci# (P65)" Mechanism It inhi-its P65" Pero&idase. Periphera# deiodination +edatives and hypnotics 6yrosine iodination 5nion (coup#in)) 6rimethoprim %eta-blockers: nonse#ective -eta;-#oc(ers"6im Pinches His Nasa# Pro-#em" (-ecause he has a runny nose444)" 6imo#o# Pindo#o# Hismo#o# Na#do#o# Proprano#o# Methyldopa: side effects METHF2#OP": Menta# retardation E#ectro#yte im-a#ance 6o#erance Opiates Po#ymy&ins %en7odia7epenes: antidote (%en is off with the fl$(: ,en/odia/epine effects off %ith 0#uma/eni#4 Respiratory depression ind$cin dr$ s (!TOP breathin (: