Professional Documents
Culture Documents
A
poisonous item can prove especially toxic when
a story about it gets into the hands of a national
newspaper. So after Sunday Times columnist
Rod Liddle made an ill-judged contribution to the
animal welfare debate, staff at the VPIS prepared
themselves to deal with a flurry of calls asking for
advice on treating ethylene glycol toxicity in pets.
Liddles big idea was to write a piece applauding
the actions of Katherine Hall who left a tray of tuna
laced with antifreeze to keep her neighbours cats
out of her garden. Both cats died and she was
ordered to pay 1500 in compensation to the
distraught owner. The item brought angry protests
from the BSAVA, BVA and welfare charities, and
raised concerns at the VPIS over the risks of
copycat actions by other people with grievances
against their neighbours pets.
Alex Campbell says there was some evidence of
an increase in enquiries about possible antifreeze
toxicity to the unit in the weeks after the article
appeared. However, before they can say that there
was a significant effect, the staff will have to examine
the data carefully, including the information returning
from practices on the clinical outcomes.
Certainly, there have been incidents in the past in
which people who may not been aware of the toxicity
of a commonly available product were motivated to
use it after reading about its effects a spate of
suicides in the 1980s caused by people ingesting the
herbicide paraquat is the classic example, Alex says.
However, unless there is a rash of enquiries from the
same area, it may be difficult to pick out a sudden
increase against normal background levels,
particularly in early winter when there is an increased
risk of accidental exposure to antifreeze.
Reporting cases
Moreover, not all small animal practices in the
country are subscribers to the VPIS and those that
have already encountered poisoning cases involving
these compounds may no longer need any advice on
how to deal with them. So, the VPIS cannot give
definitive figures on the total numbers of poisoning
cases around the country involving any specific agent,
but it can highlight trends, as well as giving invaluable
guidance for dealing with specific cases.
In 2009, the 14 full time staff at the toxicology unit
handled about 22,000 enquiries from veterinary
practices. That is only part of their workload, as their
primary role is in taking calls from hospital doctors and
GPs on dealing with human poisoning cases. In
addition, they offer other specialist services, such as a
herbal and traditional Chinese medicine advice line
and assistance to the pharmaceutical industry in
conducting clinical trials.
About 1100 veterinary businesses and more than
2000 individual clinics subscribed to the service in
2008, according to the units latest annual report.
This is a 4% increase on registrations in the previous
year. The number of enquiries has also shown a steady
10 to 15% growth over the past few years. Since the
total number of incidents is unlikely to have grown
significantly, this probably reflects a greater awareness
by veterinary surgeons of the value of the service.
When the demand eventually does start to plateau, this
will probably give a more accurate picture of the
overall scale of the problem with poisoning cases in
small animal practice, Alex notes.
In the meantime, his colleagues are seeking to
fine-tune the service offered to subscribers with a
complete overhaul of a database which contains details
of more than 160,000 cases. The new system should be
up and running by April 2010 and will allow researchers
to analyse the data with much greater precision
picking out incidents by individual postcodes and
focussing on incidents in specific breeds.
Types of cases
The overwhelming majority of cases on the VPIS files
involve dogs, which are much more likely to become
the victims of accidental poisoning than cats. The
latter will more frequently ingest a toxin when licking off
a material that has contaminated their coat hence
incidents involving the pollen of lilies and home
decorating products are common reasons for
contacting the unit.
Of course, with dogs it is their undiscriminating
appetites that get them into trouble chocolate,
analgesic drugs and rodenticides are regular products
in the top 10 reports. Labrador Retrievers, Jack Russell
Terriers, West Highland Whites and Staffordshire Bull
Terriers are invariably among the most common
04-07 Poisons.indd 5 19/1/10 08:54:56
VPIS
4
|
companion
Poisons in pets
The Veterinary Poisons Information
Service at Guys Hospital in London
provides a vital function in our
profession proven recently when a
newspaper article about antifreeze
poisoning caused a furore and
potentially more cases. Manager
Alex Campbell tells John Bonner
about the role the service plays and
its plans for the future
04-07 Poisons.indd 4 19/1/10 08:54:56
companion
|
5
VPIS
A
poisonous item can prove especially toxic when
a story about it gets into the hands of a national
newspaper. So after Sunday Times columnist
Rod Liddle made an ill-judged contribution to the
animal welfare debate, staff at the VPIS prepared
themselves to deal with a flurry of calls asking for
advice on treating ethylene glycol toxicity in pets.
Liddles big idea was to write a piece applauding
the actions of Katherine Hall who left a tray of tuna
laced with antifreeze to keep her neighbours cats
out of her garden. Both cats died and she was
ordered to pay 1500 in compensation to the
distraught owner. The item brought angry protests
from the BSAVA, BVA and welfare charities, and
raised concerns at the VPIS over the risks of
copycat actions by other people with grievances
against their neighbours pets.
Alex Campbell says there was some evidence of
an increase in enquiries about possible antifreeze
toxicity to the unit in the weeks after the article
appeared. However, before they can say that there
was a significant effect, the staff will have to examine
the data carefully, including the information returning
from practices on the clinical outcomes.
Certainly, there have been incidents in the past in
which people who may not been aware of the toxicity
of a commonly available product were motivated to
use it after reading about its effects a spate of
suicides in the 1980s caused by people ingesting the
herbicide paraquat is the classic example, Alex says.
However, unless there is a rash of enquiries from the
same area, it may be difficult to pick out a sudden
increase against normal background levels,
particularly in early winter when there is an increased
risk of accidental exposure to antifreeze.
Reporting cases
Moreover, not all small animal practices in the
country are subscribers to the VPIS and those that
have already encountered poisoning cases involving
these compounds may no longer need any advice on
how to deal with them. So, the VPIS cannot give
definitive figures on the total numbers of poisoning
cases around the country involving any specific agent,
but it can highlight trends, as well as giving invaluable
guidance for dealing with specific cases.
In 2009, the 14 full time staff at the toxicology unit
handled about 22,000 enquiries from veterinary
practices. That is only part of their workload, as their
primary role is in taking calls from hospital doctors and
GPs on dealing with human poisoning cases. In
addition, they offer other specialist services, such as a
herbal and traditional Chinese medicine advice line
and assistance to the pharmaceutical industry in
conducting clinical trials.
About 1100 veterinary businesses and more than
2000 individual clinics subscribed to the service in
2008, according to the units latest annual report.
This is a 4% increase on registrations in the previous
year. The number of enquiries has also shown a steady
10 to 15% growth over the past few years. Since the
total number of incidents is unlikely to have grown
significantly, this probably reflects a greater awareness
by veterinary surgeons of the value of the service.
When the demand eventually does start to plateau, this
will probably give a more accurate picture of the
overall scale of the problem with poisoning cases in
small animal practice, Alex notes.
In the meantime, his colleagues are seeking to
fine-tune the service offered to subscribers with a
complete overhaul of a database which contains details
of more than 160,000 cases. The new system should be
up and running by April 2010 and will allow researchers
to analyse the data with much greater precision
picking out incidents by individual postcodes and
focussing on incidents in specific breeds.
Types of cases
The overwhelming majority of cases on the VPIS files
involve dogs, which are much more likely to become
the victims of accidental poisoning than cats. The
latter will more frequently ingest a toxin when licking off
a material that has contaminated their coat hence
incidents involving the pollen of lilies and home
decorating products are common reasons for
contacting the unit.
Of course, with dogs it is their undiscriminating
appetites that get them into trouble chocolate,
analgesic drugs and rodenticides are regular products
in the top 10 reports. Labrador Retrievers, Jack Russell
Terriers, West Highland Whites and Staffordshire Bull
Terriers are invariably among the most common
04-07 Poisons.indd 5 19/1/10 08:54:56
VPIS
Poisons in pets
victims in these incidents, he says. The numbers of
serious incidents involving long-acting anticoagulant
rodenticides is a particular concern at the moment
following the withdrawal of the only oral vitamin K
based antidote available in the UK
. Often it will be
impractical for these animals to receive the number of
doses of the injectible product needed every day to
counteract an agent with such a long half life. This is
something we will be watching very closely, Alex says.
Working with the profession
The success of the VPIS initiative has been entirely
dependent on a two-way exchange of information
between the unit and its subscriber practices.
Following between 50 and 60% of enquiries, the unit
sends a form requesting further details of the case and
its outcomes. About half of those forms are returned
an impressively high response rate for any
questionnaire survey. Yes, it helps that we send these
out with a reply paid envelope and that most veterinary
practices are small organisations in which people
remember the details of a case. But I think the main
reason why the return rate is so good is that vets
appreciate that their efforts matter. The information that
they can give goes straight into the database where it
helps to refine the advice that we are able to give. Our
subscribers feel that they have ownership of this
information and long may that remain so.
Many vets will also know how lucky they are to
have a dedicated national veterinary toxicology
service. Outside the UK, there are only two
comparable initiatives that Alex is aware of. These are
a poisons information service run by a leading US
welfare charity and a French scheme, which is mainly
geared towards farm animal cases. Moreover, the
latter does not attempt to provide the sort of 24 hour,
365 day service that VPIS provides.
VPIS has some subscribers in the Irish Republic
and also gives advice on veterinary issues to the
human toxicology services that operate in many EU
neighbours. However, while it has considered the
possibility of extending the service to veterinary
surgeons abroad, this is not an immediate priority.
Alex points out that there are risks in trying to provide
advice to veterinary surgeons in situations where there
are major linguistic and cultural differences. Even in
countries like Australia and South Africa with a
common language, the major differences in the local
flora and fauna could affect our ability to provide a
comprehensive information service.
Future of the Service
So the long-term future of the service will depend on
Alexs employer, the Guys and St Thomas NHS
Foundation Trust, reaching an equitable arrangement
with its veterinary customers that will allow the service
to at least meet its running costs.
This is bound to result in changes to the current
arrangements under which subscribers pay a single
annual fee based on the numbers of veterinarians
employed in the practice. Alex points out that this may
not be an attractive option for a small practice which
rarely has any need to contact the service. On the
other hand, it is often a very attractive arrangement for
large practices and those providing a dedicated
emergency service providers, which make a growing
proportion of the out-of-hours calls.
Future arrangements are likely to be more like a
mobile telephone contract, with all subscribers
paying a small annual registration fee and then
buying a call package which allows them so many
enquiries over the period of the contract. Under this
sort of pay-per-use arrangement, the cost of each
enquiry will be set at a notional 20 to 25; being
more transparent than the current arrangements, this
can then be charged back to the pet-owning client.
VPIS managers have considered whether the
charges should include a time element to take
account of the complexity of the enquiry or whether it
was made as an evening or weekend call. However,
for simplicity, it is likely that all enquiries will be treated
exactly the same.
Practices should find these arrangements easier to
manage, particularly after the VPIS has finalised the
development of a software package that will allow
client practices to monitor their account online and to
buy credit for further enquiries whenever it is needed.
VPIS hopes these arrangements will be in place by the
end of next year.
One situation in which these arrangements may not
suit the practice is in the case of triage calls where
the pet owners initial telephone enquiry does not
result in a chargeable consultation. In that scenario,
the veterinary practice will either have to overcome the
professions traditional reluctance to charge for
telephone advice or they should simply accept the
financial penalty of having to make a call to the VPIS,
Alex notes.
Communication
To date, the VPIS has kept a fairly low public profile,
dealing almost exclusively with medical professionals
and making little effort to interact with the general
See: www.bsava.com/News/FeaturedArticles/
AvailabilityofVitaminK/tabid/706/Default.aspx
6
|
companion
04-07 Poisons.indd 6 19/1/10 08:54:56
companion
|
7
VPIS
WHEN REPORTING A POISON
For any member of staff at a veterinary practice who takes a call about a presumed toxicological emergency, it is a good idea to
begin the conversation by taking the clients contact details, in case the connection is lost. They should then try to get the essential
details from the client that will shape the later clinical management of the case but be warned, this is no simple task if the client
is distressed.
The first questions should relate to the patient. It is vital to know the following details:
Species
Breed
Age
Sex
Weight (a best estimate may have to do)
Other details past medical history, whether pregnant or lactating and whether on any current medication
The client should then be asked essential details about the presumed poison:
Full name of the product (as it appears on the packaging)
The strength/concentration of the active ingredients
The manufacturers name
Other components (including solvents and excipients)
Presentation or packaging details (tablets, capsules, bottle, etc.)
Presentation during the incident (whether concentrated or diluted, etc.)
For plants and other natural materials which part was consumed (leaves, berries, etc.)
Quantity of material ingested (it can be helpful to ask how much remains in order to assess how much has been consumed)
The practice will also need to know some other details, such as when the exposure occurred. The first obvious step is to prevent any
further contact with the toxin and to check on the safety of any other animals that are not currently showing clinical signs. Clients
should be warned to avoid coming into contact with the presumed toxin themselves. If it is appropriate for the client to attend the
surgery with their animal; they should be asked to bring along a sample of the product or packaging.
There are many sources of useful information, such as standard toxicology textbooks, that can be useful in directing treatment of the
patient. The Internet can be a helpful tool in obtaining details about a particular drug or plant but staff should be aware that much of
the information available online is unreferenced and may only relate to the effects of toxins in human patients. So the VPIS is the best
source of data specific to veterinary patients and can be accessed by any registered veterinary professional.
The service moved in November 2009 to new offices. Its full address is VPIS, Medical Toxicology Information Service,
Mary Sheridan House, Guys Hospital, Great Maze Pond, London SE1 9RT
Tel 020 7188 0200 Fax 020 7188 0700 Email vpis@gstt.nhs.uk
public. However, in another change of policy, its staff
are planning to start communicating more directly with
pet owners by posting information on its website
www.vpisuk.co.uk on toxicology issues. Much of this
will involve brochures and other downloadable
documents produced in association with animal
charities and veterinary organisations. They hope that
improving the quality of information publicly available
will reduce the number of false alarms, causing less
stress for the owner and avoiding needless activity for
their veterinary staff.
VPIS is also planning to improve the quality of the
dialogue that it has with its subscriber practices. This
will include the production of a newsletter drawing
attention to issues such as that mentioned earlier the
recent withdrawal of a key treatment used against a
common cause of poisoning in pet animals. For many
years, VPIS staff have provided regular training for
veterinary students and now plans to extend their CPD
activities with one-day courses for veterinary surgeons
and VNs. There are also plans for VPIS staff to meet
their clients face to face, with stands in the exhibitions
at BSAVA Congress and other major professional
meetings, Alex explains.
VPIS
I think the main reason why the return
rate is so good is that vets appreciate
that their efforts matter. The information
that they can give goes straight into the
database where it helps to refine the
advice that we are able to give
04-07 Poisons.indd 7 19/1/10 08:54:58
VPIS
Poisons in pets
victims in these incidents, he says. The numbers of
serious incidents involving long-acting anticoagulant
rodenticides is a particular concern at the moment
following the withdrawal of the only oral vitamin K
based antidote available in the UK
. Often it will be
impractical for these animals to receive the number of
doses of the injectible product needed every day to
counteract an agent with such a long half life. This is
something we will be watching very closely, Alex says.
Working with the profession
The success of the VPIS initiative has been entirely
dependent on a two-way exchange of information
between the unit and its subscriber practices.
Following between 50 and 60% of enquiries, the unit
sends a form requesting further details of the case and
its outcomes. About half of those forms are returned
an impressively high response rate for any
questionnaire survey. Yes, it helps that we send these
out with a reply paid envelope and that most veterinary
practices are small organisations in which people
remember the details of a case. But I think the main
reason why the return rate is so good is that vets
appreciate that their efforts matter. The information that
they can give goes straight into the database where it
helps to refine the advice that we are able to give. Our
subscribers feel that they have ownership of this
information and long may that remain so.
Many vets will also know how lucky they are to
have a dedicated national veterinary toxicology
service. Outside the UK, there are only two
comparable initiatives that Alex is aware of. These are
a poisons information service run by a leading US
welfare charity and a French scheme, which is mainly
geared towards farm animal cases. Moreover, the
latter does not attempt to provide the sort of 24 hour,
365 day service that VPIS provides.
VPIS has some subscribers in the Irish Republic
and also gives advice on veterinary issues to the
human toxicology services that operate in many EU
neighbours. However, while it has considered the
possibility of extending the service to veterinary
surgeons abroad, this is not an immediate priority.
Alex points out that there are risks in trying to provide
advice to veterinary surgeons in situations where there
are major linguistic and cultural differences. Even in
countries like Australia and South Africa with a
common language, the major differences in the local
flora and fauna could affect our ability to provide a
comprehensive information service.
Future of the Service
So the long-term future of the service will depend on
Alexs employer, the Guys and St Thomas NHS
Foundation Trust, reaching an equitable arrangement
with its veterinary customers that will allow the service
to at least meet its running costs.
This is bound to result in changes to the current
arrangements under which subscribers pay a single
annual fee based on the numbers of veterinarians
employed in the practice. Alex points out that this may
not be an attractive option for a small practice which
rarely has any need to contact the service. On the
other hand, it is often a very attractive arrangement for
large practices and those providing a dedicated
emergency service providers, which make a growing
proportion of the out-of-hours calls.
Future arrangements are likely to be more like a
mobile telephone contract, with all subscribers
paying a small annual registration fee and then
buying a call package which allows them so many
enquiries over the period of the contract. Under this
sort of pay-per-use arrangement, the cost of each
enquiry will be set at a notional 20 to 25; being
more transparent than the current arrangements, this
can then be charged back to the pet-owning client.
VPIS managers have considered whether the
charges should include a time element to take
account of the complexity of the enquiry or whether it
was made as an evening or weekend call. However,
for simplicity, it is likely that all enquiries will be treated
exactly the same.
Practices should find these arrangements easier to
manage, particularly after the VPIS has finalised the
development of a software package that will allow
client practices to monitor their account online and to
buy credit for further enquiries whenever it is needed.
VPIS hopes these arrangements will be in place by the
end of next year.
One situation in which these arrangements may not
suit the practice is in the case of triage calls where
the pet owners initial telephone enquiry does not
result in a chargeable consultation. In that scenario,
the veterinary practice will either have to overcome the
professions traditional reluctance to charge for
telephone advice or they should simply accept the
financial penalty of having to make a call to the VPIS,
Alex notes.
Communication
To date, the VPIS has kept a fairly low public profile,
dealing almost exclusively with medical professionals
and making little effort to interact with the general
See: www.bsava.com/News/FeaturedArticles/
AvailabilityofVitaminK/tabid/706/Default.aspx
6
|
companion
04-07 Poisons.indd 6 19/1/10 08:54:56
companion
|
7
VPIS
WHEN REPORTING A POISON
For any member of staff at a veterinary practice who takes a call about a presumed toxicological emergency, it is a good idea to
begin the conversation by taking the clients contact details, in case the connection is lost. They should then try to get the essential
details from the client that will shape the later clinical management of the case but be warned, this is no simple task if the client
is distressed.
The first questions should relate to the patient. It is vital to know the following details:
Species
Breed
Age
Sex
Weight (a best estimate may have to do)
Other details past medical history, whether pregnant or lactating and whether on any current medication
The client should then be asked essential details about the presumed poison:
Full name of the product (as it appears on the packaging)
The strength/concentration of the active ingredients
The manufacturers name
Other components (including solvents and excipients)
Presentation or packaging details (tablets, capsules, bottle, etc.)
Presentation during the incident (whether concentrated or diluted, etc.)
For plants and other natural materials which part was consumed (leaves, berries, etc.)
Quantity of material ingested (it can be helpful to ask how much remains in order to assess how much has been consumed)
The practice will also need to know some other details, such as when the exposure occurred. The first obvious step is to prevent any
further contact with the toxin and to check on the safety of any other animals that are not currently showing clinical signs. Clients
should be warned to avoid coming into contact with the presumed toxin themselves. If it is appropriate for the client to attend the
surgery with their animal; they should be asked to bring along a sample of the product or packaging.
There are many sources of useful information, such as standard toxicology textbooks, that can be useful in directing treatment of the
patient. The Internet can be a helpful tool in obtaining details about a particular drug or plant but staff should be aware that much of
the information available online is unreferenced and may only relate to the effects of toxins in human patients. So the VPIS is the best
source of data specific to veterinary patients and can be accessed by any registered veterinary professional.
The service moved in November 2009 to new offices. Its full address is VPIS, Medical Toxicology Information Service,
Mary Sheridan House, Guys Hospital, Great Maze Pond, London SE1 9RT
Tel 020 7188 0200 Fax 020 7188 0700 Email vpis@gstt.nhs.uk
public. However, in another change of policy, its staff
are planning to start communicating more directly with
pet owners by posting information on its website
www.vpisuk.co.uk on toxicology issues. Much of this
will involve brochures and other downloadable
documents produced in association with animal
charities and veterinary organisations. They hope that
improving the quality of information publicly available
will reduce the number of false alarms, causing less
stress for the owner and avoiding needless activity for
their veterinary staff.
VPIS is also planning to improve the quality of the
dialogue that it has with its subscriber practices. This
will include the production of a newsletter drawing
attention to issues such as that mentioned earlier the
recent withdrawal of a key treatment used against a
common cause of poisoning in pet animals. For many
years, VPIS staff have provided regular training for
veterinary students and now plans to extend their CPD
activities with one-day courses for veterinary surgeons
and VNs. There are also plans for VPIS staff to meet
their clients face to face, with stands in the exhibitions
at BSAVA Congress and other major professional
meetings, Alex explains.
VPIS
I think the main reason why the return
rate is so good is that vets appreciate
that their efforts matter. The information
that they can give goes straight into the
database where it helps to refine the
advice that we are able to give
04-07 Poisons.indd 7 19/1/10 08:54:58
8
|
companion
CLINICAL CONUNDRUM
Clinical
conundrum
Create a Problem List based on the
history and physical examination
a) Coughing and Haemoptysis
b) Tachypnoea with shallow breathing, and abnormal
lung sounds
c) Pallor
d) Lethargy, inappetence and weakness
What differential diagnoses should be
considered at this stage
The causes of haemoptysis following a period of
coughing can be split into those associated with
pulmonary or cardiac diseases. Defects of coagulation,
either congenital or acquired (rodenticide toxicity), are
unlikely to cause coughing for a prolonged period prior
to the development of haemoptysis but cannot be
completely excluded on this basis.
V n ascular
Cardiogenic pulmonary oedema (left-sided
heart disease) typically pink-tinged rather
than haemorrhagic fluid
Ruptured arteriovenous fistula (rarely causes
haemoptysis)
Bacterial endocarditis (rarely causes
haemoptysis)
Pulmonary hypertension: Congenital or
acquired cardiac defects that result in shunting
of blood (rarely causes haemoptysis)
Pulmonary thromboembolism: Secondary to
neoplastic, endocrine, cardiac, metabolic
disease (rarely causes haemoptysis)
I n nflammatory/Infectious
Chronic bronchitis/bronchiectasis
Bacterial pneumonia
Pulmonary abscess
Parasites: Angiostrongylus vasorum
Eosinophilic bronchopneumopathy
T n rauma: Pulmonary contusion; tracheal rupture;
foreign body (FB)
A n nomalous: Lung lobe torsion (rarely causes
haemoptysis)
N n eoplasia: Primary lung and tracheal tumours;
metastatic disease.
It is most likely that the tachypneoa, abnormal lung
sounds and shallow breathing pattern are caused by
the same pathology as that causing the coughing
and haemoptysis.
Pallor is indicative of poor perfusion and could be
associated with compromise of the cardiorespiratory
system or by anaemia. Investigation of the differentials
of haemoptysis should elucidate if this clinical sign
requires investigation in its own right,
Lethargy, inappetence and weakness are non-
specific signs of systemic disease, and investigation
into the system-specific problems is likely to elucidate
their cause.
What initial investigations would you
consider?
Thoracic radiography will be the first step in this case.
It will give information to further localise the cause of
the haemoptysis to the cardiovascular or respiratory
system and will provide some information as to the
nature of the pathological process occurring. In light of
the pallor, and the (slight) possibility of a coagulopathy,
blood samples should be taken to assess PCV, platelet
number and clotting profile.
Gawain Hammond of the Faculty of Veterinary
Medicine, University of Glasgow and
Chairman of EAVDI (British & Irish Division)
invites companion readers to consider the
investigation of haemoptysis in a young
Border Collie
Case presentation
A 2-year-old male Border Collie presented with a one week history
of progressive lethargy and inappetence, with shallow breathing,
coughing and the development of haemoptysis in the last 48 hours.
Treatment with antibiotics and non-steroidal anti-inflammatories had
produced little improvement.
On physical examination, the mucous membranes were pale, and
bilaterally increased harsh lung sounds were discovered on thoracic
auscultation. The patient was weak, but without obvious
neurological deficits and there was evidence of tachypnoea and
shallow breathing.
08-11 Clinical Conundrum.indd 8 19/1/10 08:42:01
companion
|
9
CLINICAL CONUNDRUM
Clinical conundrum
The haematology shows a marked leucocytosis and
neutrophilia, some showing toxic changes, suggestive
of an acute inflammatory or infectious process. There
is also a mild thrombocytopenia. Clotting profiles were
within normal limits.
In light of the radiographic and
haematological findings refine your
differential diagnosis list
Differential diagnoses for a lobar consolidation include
lobar pneumonia (bacterial, foreign body, fungal, etc.),
lobar neoplasia, lobar haemorrhage, atelectic change
and lung lobe torsion. In this case there is no evidence
of mediastinal shift towards the affected lobe to
suggest atelectasis (collapse) and there is no evidence
of pleural effusion or distortion of the bronchial tree
seen to suggest lung lobe torsion. The major
differential diagnoses for the more diffuse alveolar
pattern seen cranioventrally include pneumonia,
pulmonary haemorrhage, pulmonary oedema and
possibly pulmonary neoplasia.
Haematological changes are not consistent with a
coagulopathy as the cause of the observed clinical
signs but instead could be caused by any infectious or
inflammatory focus.
What further diagnostic procedures
could you consider without
anaesthetising the patient?
Where there is pulmonary lobar consolidation,
ultrasound investigation of the lung can be considered.
As long as there is not aerated lung interposed
between the thoracic wall and the consolidated area of
lung, the lung can be viewed via an intercostal
approach. This will require a transducer with a small
footprint or contact area phased array and
microconvex transducers are particularly useful for this.
The parenchyma of the consolidated lung can be
assessed for the presence of bronchial structures and
gas bubbles (which may give a starry appearance of
brightly echogenic foci with distal shadowing) and also
for the homogeneity of the lung parenchyma. A diffusely
hypoechoic lung with uniform echotexture may be seen
with atelectasis, lobar pneumonia, lobar haemorrhage
or lung lobe torsion in these cases the lung often
resembles the ultrasonographic image of liver.
A more heterogenous parenchyma with loss of the
normal shape and occasionally more defined rounded
areas may be seen with lobar neoplasia, granuloma
formation or abscessation. Where the lung is
completely consolidated, bronchi may be seen as
structures with parallel slightly hyperechoic walls and
an anechoic centre due to the presence of fluid within
the bronchial lumen.
What is your interpretation of ultrasound
images from this case?
Both are still images taken of the consolidated left
caudal lung lobe using an intercostal approach.
Figure 2a shows consolidated lung parenchyma
with a heterogenous appearance the cursors
B A
Figure 2
08-11 Clinical Conundrum.indd 10 19/1/10 08:42:05
companion
|
11
CLINICAL CONUNDRUM
indicate the margins of a rounded fairly well-defined
nodular area with uneven echogenicity within the lung
parenchyma. Figure 2b shows a tubular structure with
anechoic luminal content traversing the area of
consolidated lung being imaged. Within the lumen of
this tubular structure is a linear hyperechoic structure
(indicated by the cursor). In addition, in this section of
the consolidated lung lobe, multiple hyperechoic
speckles, some with faint distal reverberation, can be
seen, consistent with air bubbles within the
parenchyma of the lung. The tubular structure may be
a fluid-filled bronchus or a blood vessel however no
flow could be detected in this structure using Doppler
imaging, suggesting a bronchus was more likely.
The sonographic findings indicate consolidation
with alteration of the parenchyma of the left caudal
lung lobe, suggesting abscessation, granuloma
formation or neoplasia. The hyperechoic structure
within the bronchus was suspected to be a bronchial
foreign body (possibly a grass seed).
What are your final conclusions from the
results of the imaging studies?
Combining the results of the radiographic and
ultrasonographic studies, the suggestion is of a lobar
pneumonia ( lobar haemorrhage) with abscessation
or granuloma formation due to the presence of a
bronchial foreign body. There is also a suspicion of
more diffuse pneumonia and/or pulmonary
haemorrhage affecting other lung lobes.
What further steps and therapy could be
considered?
In this case, after the patient was stabilised and
anaesthetised, bronchoscopy was performed.
However, the haemorrhage within the bronchial tree
prevented a final diagnosis being reached. At this
stage, options for further investigation would include
thoracic CT or surgical exploration.
The patient was taken to surgery, where a left
7th intercostal thoracotomy was performed. The left
caudal lung lobe was swollen and solid on palpation,
with visible abscessation formation at the
caudodorsal tip. There were multiple areas where the
parenchyma was disrupted, and no functional tissue
EAVDI-BID ABSTRACT PRIZE
The British and Irish Division of the European Association of Veterinary
Diagnostic Imaging (EAVDI-BID) organises two annual meetings (one
pre-BSAVA satellite meeting in Birmingham the day before BSAVA
Congress, and one two-day autumn meeting, usually in October or
November) covering a wide range of imaging topics. Membership is open
to anyone with an interest in veterinary diagnostic imaging. Starting in
2010, the Division is creating a prize to be awarded to the best abstract
presented in the Diagnostic Imaging stream of the Clinical Research
Abstracts presented at the annual BSAVA Congress. The prize will consist
of a book voucher, as well as free registration for the subsequent
EAVDI-BID Autumn meeting, where the winning author will be invited to
present the abstract. If there are any queries, please visit the EAVDI-BID
website (http://cheval.vet.gla.ac.uk/EVDI/ea-bed.htm) or email
g.hammond@vet.gla.ac.uk
could be identified in the lobe. The entire lobe was
removed, and when the bronchial tree was opened, a
chain of multiple grass seeds was found in the
bronchial tree. No evidence of pyothorax or
mediastinal disease was found.
The patient recovered well following surgery, and
was discharged four days after surgery. A swab taken
from the excised lung lobe showed a significant
growth of Escherichia coli.
Use of ultrasound in pulmonary disease
Ultrasonography of the thoracic cavity is not limited to
echocardiography. As long as there is not aerated
lung interposed between the transducer and the
structure of interest, ultrasound examination can add
valuable information to that obtained from thoracic
radiography regarding pulmonary, pleural and
mediastinal disease. The easiest method is to identify
the area of the thoracic wall overlying the lesion from
the thoracic radiographs, and to place the transducer
between the intercostal spaces in this area.
If the lesion is in contact with the thoracic wall,
the parenchymal appearance can be assessed.
In addition, fine needle aspirates of peripheral
pulmonary or large mediastinal masses or pleural
effusions can be obtained under ultrasound guidance
for further analysis. n
08-11 Clinical Conundrum.indd 11 19/1/10 08:42:05
10
|
companion
CLINICAL CONUNDRUM
Clinical conundrum
The haematology shows a marked leucocytosis and
neutrophilia, some showing toxic changes, suggestive
of an acute inflammatory or infectious process. There
is also a mild thrombocytopenia. Clotting profiles were
within normal limits.
In light of the radiographic and
haematological findings refine your
differential diagnosis list
Differential diagnoses for a lobar consolidation include
lobar pneumonia (bacterial, foreign body, fungal, etc.),
lobar neoplasia, lobar haemorrhage, atelectic change
and lung lobe torsion. In this case there is no evidence
of mediastinal shift towards the affected lobe to
suggest atelectasis (collapse) and there is no evidence
of pleural effusion or distortion of the bronchial tree
seen to suggest lung lobe torsion. The major
differential diagnoses for the more diffuse alveolar
pattern seen cranioventrally include pneumonia,
pulmonary haemorrhage, pulmonary oedema and
possibly pulmonary neoplasia.
Haematological changes are not consistent with a
coagulopathy as the cause of the observed clinical
signs but instead could be caused by any infectious or
inflammatory focus.
What further diagnostic procedures
could you consider without
anaesthetising the patient?
Where there is pulmonary lobar consolidation,
ultrasound investigation of the lung can be considered.
As long as there is not aerated lung interposed
between the thoracic wall and the consolidated area of
lung, the lung can be viewed via an intercostal
approach. This will require a transducer with a small
footprint or contact area phased array and
microconvex transducers are particularly useful for this.
The parenchyma of the consolidated lung can be
assessed for the presence of bronchial structures and
gas bubbles (which may give a starry appearance of
brightly echogenic foci with distal shadowing) and also
for the homogeneity of the lung parenchyma. A diffusely
hypoechoic lung with uniform echotexture may be seen
with atelectasis, lobar pneumonia, lobar haemorrhage
or lung lobe torsion in these cases the lung often
resembles the ultrasonographic image of liver.
A more heterogenous parenchyma with loss of the
normal shape and occasionally more defined rounded
areas may be seen with lobar neoplasia, granuloma
formation or abscessation. Where the lung is
completely consolidated, bronchi may be seen as
structures with parallel slightly hyperechoic walls and
an anechoic centre due to the presence of fluid within
the bronchial lumen.
What is your interpretation of ultrasound
images from this case?
Both are still images taken of the consolidated left
caudal lung lobe using an intercostal approach.
Figure 2a shows consolidated lung parenchyma
with a heterogenous appearance the cursors
B A
Figure 2
08-11 Clinical Conundrum.indd 10 19/1/10 08:42:05
companion
|
11
CLINICAL CONUNDRUM
indicate the margins of a rounded fairly well-defined
nodular area with uneven echogenicity within the lung
parenchyma. Figure 2b shows a tubular structure with
anechoic luminal content traversing the area of
consolidated lung being imaged. Within the lumen of
this tubular structure is a linear hyperechoic structure
(indicated by the cursor). In addition, in this section of
the consolidated lung lobe, multiple hyperechoic
speckles, some with faint distal reverberation, can be
seen, consistent with air bubbles within the
parenchyma of the lung. The tubular structure may be
a fluid-filled bronchus or a blood vessel however no
flow could be detected in this structure using Doppler
imaging, suggesting a bronchus was more likely.
The sonographic findings indicate consolidation
with alteration of the parenchyma of the left caudal
lung lobe, suggesting abscessation, granuloma
formation or neoplasia. The hyperechoic structure
within the bronchus was suspected to be a bronchial
foreign body (possibly a grass seed).
What are your final conclusions from the
results of the imaging studies?
Combining the results of the radiographic and
ultrasonographic studies, the suggestion is of a lobar
pneumonia ( lobar haemorrhage) with abscessation
or granuloma formation due to the presence of a
bronchial foreign body. There is also a suspicion of
more diffuse pneumonia and/or pulmonary
haemorrhage affecting other lung lobes.
What further steps and therapy could be
considered?
In this case, after the patient was stabilised and
anaesthetised, bronchoscopy was performed.
However, the haemorrhage within the bronchial tree
prevented a final diagnosis being reached. At this
stage, options for further investigation would include
thoracic CT or surgical exploration.
The patient was taken to surgery, where a left
7th intercostal thoracotomy was performed. The left
caudal lung lobe was swollen and solid on palpation,
with visible abscessation formation at the
caudodorsal tip. There were multiple areas where the
parenchyma was disrupted, and no functional tissue
EAVDI-BID ABSTRACT PRIZE
The British and Irish Division of the European Association of Veterinary
Diagnostic Imaging (EAVDI-BID) organises two annual meetings (one
pre-BSAVA satellite meeting in Birmingham the day before BSAVA
Congress, and one two-day autumn meeting, usually in October or
November) covering a wide range of imaging topics. Membership is open
to anyone with an interest in veterinary diagnostic imaging. Starting in
2010, the Division is creating a prize to be awarded to the best abstract
presented in the Diagnostic Imaging stream of the Clinical Research
Abstracts presented at the annual BSAVA Congress. The prize will consist
of a book voucher, as well as free registration for the subsequent
EAVDI-BID Autumn meeting, where the winning author will be invited to
present the abstract. If there are any queries, please visit the EAVDI-BID
website (http://cheval.vet.gla.ac.uk/EVDI/ea-bed.htm) or email
g.hammond@vet.gla.ac.uk
could be identified in the lobe. The entire lobe was
removed, and when the bronchial tree was opened, a
chain of multiple grass seeds was found in the
bronchial tree. No evidence of pyothorax or
mediastinal disease was found.
The patient recovered well following surgery, and
was discharged four days after surgery. A swab taken
from the excised lung lobe showed a significant
growth of Escherichia coli.
Use of ultrasound in pulmonary disease
Ultrasonography of the thoracic cavity is not limited to
echocardiography. As long as there is not aerated
lung interposed between the transducer and the
structure of interest, ultrasound examination can add
valuable information to that obtained from thoracic
radiography regarding pulmonary, pleural and
mediastinal disease. The easiest method is to identify
the area of the thoracic wall overlying the lesion from
the thoracic radiographs, and to place the transducer
between the intercostal spaces in this area.
If the lesion is in contact with the thoracic wall,
the parenchymal appearance can be assessed.
In addition, fine needle aspirates of peripheral
pulmonary or large mediastinal masses or pleural
effusions can be obtained under ultrasound guidance
for further analysis. n
08-11 Clinical Conundrum.indd 11 19/1/10 08:42:05
12
|
companion
HOW TO
How to
Place an
oesophagostomy tube
Clinical nutrition is an often neglected but
crucial part of patient management, and
nutritional support may be required for a
variety of patients. Using material from two
exciting new BSAVA publications, co-editors
Nick Bexfield and Penny Watson explain
when and how to place and use an
oesophagostomy tube
When to consider nutritional support
Special nutritional support (i.e. a change to a high-
calorie, high-protein diet and/or assisted (tube)
feeding) should be considered in cases of:
Recent weight loss: Has the dog or cat lost >10%
of its bodyweight not due to dehydration or obvious
fluid shifts (e.g. diuresis)?
This is relevant even in obese animals: weight
loss in an obese, sick animal will
predominantly be attributed to loss of lean
body mass rather than fat and this is
undesirable. Weight loss and anorexia in an
obese cat are particularly worrying because of
the risk of hepatic lipidosis.
Partial or complete anorexia for >3 days: Has
the dog or cat eaten <85% of its calculated resting
energy requirement (RER) for the last three or
more days?
Animal in very catabolic state or at risk of overt
malnutrition:
Does the animal have: severe burns; draining
sepsis, such as pyothorax or septic peritonitis;
malabsorption or protein-losing enteropathy;
or nephropathy?
If so, is it receiving enough calories and/or
protein?
Is there an obvious loss of weight or lean body
mass to suggest it is not?
Routes of enteral support
There are a few important general rules for feeding
hospitalised animals:
1. IF THE GUT WORKS, USE IT
(applies to the vast majority of our patients).
2. If only PART of the gut works,
use THAT part of the gut.
3. When feeding enterally, use the simplest route
possible which avoids stress to the animal.
4. Appetite stimulants are NOT very effective acutely
and are best reserved for when the patient has
been discharged home and is recuperating.
There are a number of advantages of feeding
animals enterally, which is why every effort should be
made to feed animals in this way. Note: Before
nutritional interventions are initiated, the patient must
be stable cardiovascularly and have had any fluid,
electrolyte and acidbase abnormalities addressed.
There are many enteral feeding methods available
to the practising veterinary surgeon, ranging from oral
or force-feeding to a number of tube-feeding methods.
When using any syringe- or force-feeding method, it is
important to ensure that the animal is receiving a
significant amount of its daily caloric requirements. If it
is not, or if it is becoming stressed by the procedure,
some sort of feeding tube should be placed.
The choice of tubes includes:
Naso-oesophageal
Oesophageal
Gastrostomy (placed at laparotomy or as a
percutaneous endoscopic gastrostomy (PEG))
Jejunostomy.
12-16 How To.indd 12 19/1/10 08:40:57
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13
HOW TO
Place an
oesophagostomy tube
3. Bluntly dissect through the subcutaneous tissues and make an
incision into the oesophagus over the tips of the forceps.
4. Push the tips of the forceps outwards through the incision to the
external surface.
5. Measure the oesophagostomy tube from this point to the 7
th
intercostal
space (distal oesophagus) and mark the tube with a piece of adhesive
tape.
8. Disengage the tips of the forceps, curl the tip of
the tube back into the mouth and feed it into the
oesophagus.
7. Draw the end of the
feeding tube through
the oesophagostomy
incision and rostrally
into the pharynx to
exit the mouth.
6. Open the tips
of the forceps
and grasp the
distal end of
the feeding
tube.
11. Secure the tube by placement of a Chinese
finger-trap/Roman Sandal suture.
12. Take a thoracic radiograph to confirm correct
tube placement: the tip of the tube should be in
the distal oesophagus, not the stomach. If the
tube does have an integral radiodense marker,
iodinated (not barium) contrast medium can be
instilled into the tube to aid visualisation.
13. Cover the tube site with a sterile dressing and
place a soft padded loose neck bandage.
1. Insert the curved forceps through the mouth and into the oesophagus,
to the mid-cervical region.
2. Turn the tip of the forceps
laterally and use
the scalpel to
make a
510 mm skin
incision over
the point of
the tips.
9. Visually inspect the oropharynx to confirm that
the tube is no longer present in the oropharynx.
10. The tube should slide easily back and forth a few
millimetres, confirming that it has straightened.
Ilustrations drawn by Samantha Elmhurst (www.livingart.com)
and reproduced with her permission
12-16 How To.indd 14 19/1/10 08:40:59
companion
|
15
HOW TO
Place an
oesophagostomy tube
3. Bluntly dissect through the subcutaneous tissues and make an
incision into the oesophagus over the tips of the forceps.
4. Push the tips of the forceps outwards through the incision to the
external surface.
5. Measure the oesophagostomy tube from this point to the 7
th
intercostal
space (distal oesophagus) and mark the tube with a piece of adhesive
tape.
8. Disengage the tips of the forceps, curl the tip of
the tube back into the mouth and feed it into the
oesophagus.
7. Draw the end of the
feeding tube through
the oesophagostomy
incision and rostrally
into the pharynx to
exit the mouth.
6. Open the tips
of the forceps
and grasp the
distal end of
the feeding
tube.
11. Secure the tube by placement of a Chinese
finger-trap/Roman Sandal suture.
12. Take a thoracic radiograph to confirm correct
tube placement: the tip of the tube should be in
the distal oesophagus, not the stomach. If the
tube does have an integral radiodense marker,
iodinated (not barium) contrast medium can be
instilled into the tube to aid visualisation.
13. Cover the tube site with a sterile dressing and
place a soft padded loose neck bandage.
1. Insert the curved forceps through the mouth and into the oesophagus,
to the mid-cervical region.
2. Turn the tip of the forceps
laterally and use
the scalpel to
make a
510 mm skin
incision over
the point of
the tips.
9. Visually inspect the oropharynx to confirm that
the tube is no longer present in the oropharynx.
10. The tube should slide easily back and forth a few
millimetres, confirming that it has straightened.
Ilustrations drawn by Samantha Elmhurst (www.livingart.com)
and reproduced with her permission
12-16 How To.indd 14 19/1/10 08:40:59
companion
|
15
HOW TO
Place an
oesophagostomy tube
BSAVA GUIDE TO PROCEDURES IN
SMALL ANIMAL PRACTICE
Editors: Nick Bexfield and Karla Lee
This completely NEW publication features common diagnostic, medical, surgical and
emergency procedures in an easy-to-use A to Z listing. Indications, contraindications,
equipment, patient positioning and preparation, and potential complications are noted
for each procedure. The techniques themselves are presented in a step-by-step
format, augmented by photographs and specially commissioned drawings (examples
of which accompany this article). Lay-flat binding allows use in the clinic or lab setting.
Every paying member of BSAVA will receive one complimentary copy as part of their membership.
Members attending Congress will be able to collect them from the BSAVA Balcony, the rest will be
sent out in May.
BSAVA MANUAL OF CANINE AND FELINE
REHABILITATION, SUPPORTIVE AND
PALLIATIVE CARE: Case studies in patient
management
Editors: Penny Watson and Samantha Lindley
This unique publication shows how a team-based approach can be used to improve
patient outcomes. Part 1 presents the latest strategies for pain management, clinical
nutrition, and physical therapy and rehabilitation. The evidence base for therapies is discussed, with
reference to published studies. Part 2 uses a range of case scenarios to illustrate how medical and surgical
treatment, dietary advice, physiotherapy, hydrotherapy, acupuncture, nursing care and homecare
recommendations can form an integrated approach to the management of individual patients.
Available Summer 2010.
The food should be warmed to body temperature
and injected over several minutes.
If the animal shows regurgitation, vomiting or
diarrhoea after feeding, reduce the amount fed in
each meal and check that the food fed is warm
and iso-osmolar.
Tube care and removal
Once a day, the neck wrap and sterile dressing
should be removed and the stoma cleaned using
cotton wool or gauze swabs soaked in 4%
chlorhexidine gluconate or 10% povidoneiodine.
If oozing of purulent liquid suggests infection,
an antibiotic ointment can be applied. A new
sterile dressing is then applied and the neck
wrap replaced.
The oesophagostomy tube can be removed when
it is no longer required; unlike a gastrotomy tube there
is no minimum length of time an oesophagostomy tube
must have been in place prior to removal. To remove
the tube, take off the dressing, remove the suture and
pull the tube gently out. The stoma site will close
rapidly once the tube is removed, but skin sutures can
be placed if preferred.
Procedures in
Small Animal
Practice
Procedures in
Small Animal Practice
BSAVA Guide to
BSAVA Guide to
Nick Bexeld
and Karla Lee
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Contents
Abdominocentesis; ACTH response test; Anaphylaxis emergency treatment;
Arthrocentesis; Aseptic preparation; Barium contrast media; Barium studies of
the gastrointestinal tract; Blood pressure measurement; Bblood sampling; Blood
smear preparation; Blood transfusion; Bone biopsy needle; Bone marrow aspiration; Bronchoalveloar lavage; Bronchoscopy; Buccal mucosal bleeding time; Cardiopulmonarycerebral resuscitation; Cardiorespiratory examination;
Cast application; Cerebrospinal uid sampling; Cranial draw test; Cystocentesis;
Dexamethasone suppression tests; Diagnostic peritoneal lavage; Ehmer sling;
Elbow luxation closed reduction; Electrocardiography; Endoscopy of the gastrointestinal tract; Endotracheal wash; Fine needle aspiration; Fluorescein test;
Gastric decompression; Gastrostomy tube placement; Haemagglutination test;
Hip luxation closed reduction; Intraosseous cannula placement; Intravenous
catheter placement; Intravenous urography; Iodinated contrast media; Myringotomy;
Nasal oxygen administration; Naso-oesophageal tube placement; Neurological
examination; Oesophagostomy tube placement; Ophthalmic examination; Orthopaedic examination; Ortolani test; Otoscopy; Pericardiocentesis; Platelet
count; Prostatic wash; Resting energy requirement; Retrograde urethrography/
vaginourethrography; Rhinoscopy; Schirmer tear test; Seizures emergency protocol; Semen collection; Skin biopsy punch biopsy; Skin and hair sampling;
Soft padded bandage; Spica splint; Thoracocentesis needle; Thoracostomy tube
placement; Tibial compression test; Tissue biopsy needle core; Tracheostomy;
Transtracheal wash; Urethral catheterization; Urethral retrograde urohydropulsion;
Urinalysis; Velpeau sling; Water deprivation test; Whole blood clotting time
Edited by Nick Bexeld and Karla Lee
The BSAVA Guide to Procedures in Small Animal Practice provides
practical, step-by-step guidance on how to perform the diagnostic and
therapeutic procedures commonly performed in small animal veterinary
practice. In addition, routine clinical examination of the major body systems,
and protocols for the management of selected emergencies are described. In addition to the actual technique, each procedure has information on
indications and contraindications, equipment required, and potential
complications, together with the editors own hints and tips. Details of
BSAVA Manuals where wider information, such as interpretation of results,
are given throughout.
Special features:
A to Z format to aid information retrieval
Extensive cross-referencing in highlighted text
Specially commissioned drawings
Lay-at binding
This is a truly useful guide, which will provide a valuable and lasting reference
for veterinary surgeons, veterinary nurses and students alike.
ISBN 978 1 905319 17 6
12-16 How To.indd 16 19/1/10 08:41:04
companion
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17
CONGRESS
Satellite meetings
at BSAVA Congress
BSAVA supports its Affiliated
Groups with funding and
promotion, as well as presenting
them with the opportunity to hold
a Satellite Meeting on the
Wednesday before Congress
(this year 7 April)
ABVA
Association of British
Veterinary Acupuncturists
Venue: Executive Room 1, ICC
Booking contact: Julie Cummings
Email: bmasgeneralmgr@aol.com
Website: www.abva.co.uk
Tel: +44 (0) 1606 786782
AVCPT
Association of Veterinary
Clinical Pharmacology and
Therapeutics
Venue: Hall 7a, ICC
Booking contact: Maria Gregory-
Carlton
Email: secretary@avcpt.org
Website: www.avcpt.org
The neurobiology of pain with
Dr Sue Fleetwood-Walker
Challenges facing new approaches to pain
management in animal species with
Dr Adrian Foster
PK/PD modelling and its relevance to
pharmacological pain intervention with
Ludovic Pelligand
Pain control in osteoarthritis with
Dr Dylan Clements
Acute Pain management in animals with
Dr Jo Murrell
The language of Pain: A human perspective with
Dr Mark Rockett
Panel discussion all speakers
100 for non-members; 70 for members; 70 for
students and residents. Lunch is included
AVSTS
Association for Veterinary
Soft Tissue Surgery
Venue: Hall 6, ICC
Booking contact: Alison Young
Email: avstsadmin@fsmail.net
Website: www.avsts.org.uk
Tel: +44 (0) 1707 666366 ex 2432
A Smrgsbord of topics awaits you at our Spring
meeting for 2010.
With a dazzling array of UK and international speakers
its sure to be a stimulating session.
BrAVO
British Association of
Veterinary Ophthalmologists
Venue: Hall 8a, ICC
Booking contact: Claudia Hartley
Email: claudia.hartley@aht.org.uk
Website: www.bravo.org.uk
Tel: +44 (0) 1638 552700
The British Association of Veterinary Ophthalmologists
(BrAVO) is an internationally recognised society of
veterinary ophthalmologists and vets with an interest in
ophthalmology. We have members not only from the
United Kingdom but also Hong Kong, Australia,
France, Belgium, Sweden, Italy and South Africa. We
are also honoured to have consultant ophthalmologists
from the human medical field as members. We are a
very sociable group, with over 250 members, and
newcomers are welcomed.
BrAVO organises two meetings each year, with
state-of-the-art lectures on all aspects of veterinary and
human ophthalmology. Our Spring meeting is a
one-day pre-BSAVA satellite meeting and includes
both local and international speakers. The winter
BAVEC
British Association of
Veterinary Emergency Care
Venue: Crompton Room,
Austin Court
Booking contact: Jan MacDonald
Email: jan.macdonald@vets-now.com
Website: www.bavec.co.uk
Tel: +44 (0) 7785 741033
17-20 Satellite Groups.indd 17 19/1/10 08:52:39
16
|
companion
HOW TO
Place an
oesophagostomy tube
BSAVA GUIDE TO PROCEDURES IN
SMALL ANIMAL PRACTICE
Editors: Nick Bexfield and Karla Lee
This completely NEW publication features common diagnostic, medical, surgical and
emergency procedures in an easy-to-use A to Z listing. Indications, contraindications,
equipment, patient positioning and preparation, and potential complications are noted
for each procedure. The techniques themselves are presented in a step-by-step
format, augmented by photographs and specially commissioned drawings (examples
of which accompany this article). Lay-flat binding allows use in the clinic or lab setting.
Every paying member of BSAVA will receive one complimentary copy as part of their membership.
Members attending Congress will be able to collect them from the BSAVA Balcony, the rest will be
sent out in May.
BSAVA MANUAL OF CANINE AND FELINE
REHABILITATION, SUPPORTIVE AND
PALLIATIVE CARE: Case studies in patient
management
Editors: Penny Watson and Samantha Lindley
This unique publication shows how a team-based approach can be used to improve
patient outcomes. Part 1 presents the latest strategies for pain management, clinical
nutrition, and physical therapy and rehabilitation. The evidence base for therapies is discussed, with
reference to published studies. Part 2 uses a range of case scenarios to illustrate how medical and surgical
treatment, dietary advice, physiotherapy, hydrotherapy, acupuncture, nursing care and homecare
recommendations can form an integrated approach to the management of individual patients.
Available Summer 2010.
The food should be warmed to body temperature
and injected over several minutes.
If the animal shows regurgitation, vomiting or
diarrhoea after feeding, reduce the amount fed in
each meal and check that the food fed is warm
and iso-osmolar.
Tube care and removal
Once a day, the neck wrap and sterile dressing
should be removed and the stoma cleaned using
cotton wool or gauze swabs soaked in 4%
chlorhexidine gluconate or 10% povidoneiodine.
If oozing of purulent liquid suggests infection,
an antibiotic ointment can be applied. A new
sterile dressing is then applied and the neck
wrap replaced.
The oesophagostomy tube can be removed when
it is no longer required; unlike a gastrotomy tube there
is no minimum length of time an oesophagostomy tube
must have been in place prior to removal. To remove
the tube, take off the dressing, remove the suture and
pull the tube gently out. The stoma site will close
rapidly once the tube is removed, but skin sutures can
be placed if preferred.
Procedures in
Small Animal
Practice
Procedures in
Small Animal Practice
BSAVA Guide to
BSAVA Guide to
Nick Bexeld
and Karla Lee
B
S
A
V
A
G
u
i d
e
t
o
P
r
o
c
e
d
u
r
e
s
i n
S
m
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l l A
n
i m
a
l P
r
a
c
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i c
e
Contents
Abdominocentesis; ACTH response test; Anaphylaxis emergency treatment;
Arthrocentesis; Aseptic preparation; Barium contrast media; Barium studies of
the gastrointestinal tract; Blood pressure measurement; Bblood sampling; Blood
smear preparation; Blood transfusion; Bone biopsy needle; Bone marrow aspiration; Bronchoalveloar lavage; Bronchoscopy; Buccal mucosal bleeding time; Cardiopulmonarycerebral resuscitation; Cardiorespiratory examination;
Cast application; Cerebrospinal uid sampling; Cranial draw test; Cystocentesis;
Dexamethasone suppression tests; Diagnostic peritoneal lavage; Ehmer sling;
Elbow luxation closed reduction; Electrocardiography; Endoscopy of the gastrointestinal tract; Endotracheal wash; Fine needle aspiration; Fluorescein test;
Gastric decompression; Gastrostomy tube placement; Haemagglutination test;
Hip luxation closed reduction; Intraosseous cannula placement; Intravenous
catheter placement; Intravenous urography; Iodinated contrast media; Myringotomy;
Nasal oxygen administration; Naso-oesophageal tube placement; Neurological
examination; Oesophagostomy tube placement; Ophthalmic examination; Orthopaedic examination; Ortolani test; Otoscopy; Pericardiocentesis; Platelet
count; Prostatic wash; Resting energy requirement; Retrograde urethrography/
vaginourethrography; Rhinoscopy; Schirmer tear test; Seizures emergency protocol; Semen collection; Skin biopsy punch biopsy; Skin and hair sampling;
Soft padded bandage; Spica splint; Thoracocentesis needle; Thoracostomy tube
placement; Tibial compression test; Tissue biopsy needle core; Tracheostomy;
Transtracheal wash; Urethral catheterization; Urethral retrograde urohydropulsion;
Urinalysis; Velpeau sling; Water deprivation test; Whole blood clotting time
Edited by Nick Bexeld and Karla Lee
The BSAVA Guide to Procedures in Small Animal Practice provides
practical, step-by-step guidance on how to perform the diagnostic and
therapeutic procedures commonly performed in small animal veterinary
practice. In addition, routine clinical examination of the major body systems,
and protocols for the management of selected emergencies are described. In addition to the actual technique, each procedure has information on
indications and contraindications, equipment required, and potential
complications, together with the editors own hints and tips. Details of
BSAVA Manuals where wider information, such as interpretation of results,
are given throughout.
Special features:
A to Z format to aid information retrieval
Extensive cross-referencing in highlighted text
Specially commissioned drawings
Lay-at binding
This is a truly useful guide, which will provide a valuable and lasting reference
for veterinary surgeons, veterinary nurses and students alike.
ISBN 978 1 905319 17 6
12-16 How To.indd 16 19/1/10 08:41:04
companion
|
17
CONGRESS
Satellite meetings
at BSAVA Congress
BSAVA supports its Affiliated
Groups with funding and
promotion, as well as presenting
them with the opportunity to hold
a Satellite Meeting on the
Wednesday before Congress
(this year 7 April)
ABVA
Association of British
Veterinary Acupuncturists
Venue: Executive Room 1, ICC
Booking contact: Julie Cummings
Email: bmasgeneralmgr@aol.com
Website: www.abva.co.uk
Tel: +44 (0) 1606 786782
AVCPT
Association of Veterinary
Clinical Pharmacology and
Therapeutics
Venue: Hall 7a, ICC
Booking contact: Maria Gregory-
Carlton
Email: secretary@avcpt.org
Website: www.avcpt.org
The neurobiology of pain with
Dr Sue Fleetwood-Walker
Challenges facing new approaches to pain
management in animal species with
Dr Adrian Foster
PK/PD modelling and its relevance to
pharmacological pain intervention with
Ludovic Pelligand
Pain control in osteoarthritis with
Dr Dylan Clements
Acute Pain management in animals with
Dr Jo Murrell
The language of Pain: A human perspective with
Dr Mark Rockett
Panel discussion all speakers
100 for non-members; 70 for members; 70 for
students and residents. Lunch is included
AVSTS
Association for Veterinary
Soft Tissue Surgery
Venue: Hall 6, ICC
Booking contact: Alison Young
Email: avstsadmin@fsmail.net
Website: www.avsts.org.uk
Tel: +44 (0) 1707 666366 ex 2432
A Smrgsbord of topics awaits you at our Spring
meeting for 2010.
With a dazzling array of UK and international speakers
its sure to be a stimulating session.
BrAVO
British Association of
Veterinary Ophthalmologists
Venue: Hall 8a, ICC
Booking contact: Claudia Hartley
Email: claudia.hartley@aht.org.uk
Website: www.bravo.org.uk
Tel: +44 (0) 1638 552700
The British Association of Veterinary Ophthalmologists
(BrAVO) is an internationally recognised society of
veterinary ophthalmologists and vets with an interest in
ophthalmology. We have members not only from the
United Kingdom but also Hong Kong, Australia,
France, Belgium, Sweden, Italy and South Africa. We
are also honoured to have consultant ophthalmologists
from the human medical field as members. We are a
very sociable group, with over 250 members, and
newcomers are welcomed.
BrAVO organises two meetings each year, with
state-of-the-art lectures on all aspects of veterinary and
human ophthalmology. Our Spring meeting is a
one-day pre-BSAVA satellite meeting and includes
both local and international speakers. The winter
BAVEC
British Association of
Veterinary Emergency Care
Venue: Crompton Room,
Austin Court
Booking contact: Jan MacDonald
Email: jan.macdonald@vets-now.com
Website: www.bavec.co.uk
Tel: +44 (0) 7785 741033
17-20 Satellite Groups.indd 17 19/1/10 08:52:39
18
|
companion
CONGRESS
meeting is a two-day weekend meeting that is held in
easy to reach locations around the country, usually in
November. Again we include international speakers,
and usually a medical speaker for a comparative view
in humans.
Members are invited to all meetings and enjoy
discounts on textbooks and journal subscriptions, as
well as eligibility to apply for one of two travel
scholarships (up to the value of 1000 per scholarship
each year) every year.
BVZS
British Veterinary
Zoological Society
Venue: Hall 7b, ICC
Booking contact: Victoria Roberts
Email: victoriaroberts06@tiscali.co.uk
Website: www.bvzs.org
Tel: +44 (0) 7971 482292
EXOTICS FOR GP VETS
Clinical management of ferrets, sugar gliders and
degus Aidan Raftery
Diagnostic approach to the sick bird Kevin Eatwell
Common lizard presentations and their
management Kevin Eatwell
Common chelonian presentations and their
management Stuart McArthur
Safe anaestheisa in rabbits and small mammals
Ian Sayers
The fourth BVZS satellite meeting provides BSAVA
delegates and small animal practitioners in general
practice the opportunity to undertake world class
continuing professional development in non-domestic
species medicine. The programme for the day
complements and expands the exotic pet content in
the main Congress, allowing further development of
your skills and understanding.
A
mericans are well known in this country for the
high quality of their dental work and so perhaps
it is not surprising that even their pets can
receive cutting edge orthodontic care. A leading
exponent of veterinary dentistry from the US has been
invited to pass on his skills to his British and European
colleagues at BSAVA Congress in Birmingham in April.
Among a series of presentations on different aspects
of oral surgery, Professor Bill Gengler of the University
of Wisconsin will outline the principles of orthodontics
to correct conditions resulting from malocclusions.
From man to beast
Appliances similar to those originally developed in
human dentistry are used with increasing frequency in
dogs on both sides of the Atlantic to create a more
regular bite. But in contrast with human orthodontics
these methods are never used simply for cosmetic
reasons. The orthodontic procedures that we do
perform are only for the health and comfort of the
animal, he explains.
As a member of the American Veterinary
Dental College, he uses these techniques to
prevent or to treat the painful consequences
of malocclusions, not to give the dogs
owners hope of success in shows. As a
group, we are very ethical and try not to
change the appearance so it will have an
advantage in the ring. We also encourage
owners to neuter animals that have
orthodontic treatment resulting from
hereditary defects.
Problems and solutions
Two defects which these methods are often used to
treat are linguoversion of the mandibular
canine teeth (or base narrow canines)
and rostroversion of the maxillary
canine tooth. The former can be a
very painful condition and occurs
mainly in long-nosed dogs such as
Labradors, German Shepherd Dogs
and Standard Poodles. Affected
animals have very narrow mandibles
and lower canine teeth that erupt
vertically, with the result that over time
Bit between
the teeth
at Congress
Dentistry lectures are always
especially popular at
Congress and even more
so when a leading expert
shares their skills
21-22 Congress.indd 21 19/1/10 08:53:09
20
|
companion
CONGRESS
ESFM
European Society of
Feline Medicine
Venue: Hall 10, ICC
Booking contact:
Amanda Dennant
Email: conferences@fabcats.org
Website: fabcats.org/conferences
Tel: +44 (0) 1747 871872
Who could argue that cats can be difficult! But then
they can also be fascinating because they dont follow
the rules. However you think of them, they are now a
large part of companion animal practice.
At the European Society of Feline Medicine (ESFM)
pre-Congress day we aim to cover current feline issues
and to provide as much as possible to take back to
practice. This year we are also introducing four practice
tip sessions all cover ins and outs with cats blocked
cats, using catheters, feeding the anorexic cat, and
getting medicines in. Other international speakers will
follow last years very popular approach of 30 minute
update talks on food allergies, atopy, asthma,
ureteroliths and thyroidectomy technique.
Through its monthly international peer-reviewed
Journal of Feline Medicine and Surgery (JFMS) ESFM
provides both basic science and practical clinical
reviews from world leaders for the advancement of
understanding of disease and the treatment of cats in
daily veterinary practice.
Visit www.fabcats.org/conferences/bsava/2010 to
find out more and to book your place dont leave it
too late; we were sold out last year!
consultant in medicine and critical care and a member
of the guideline development group for venous
thromboembolism prevention for the National Institute
of Clinical Excellence (NICE). For those attendees that
are in the processing of writing their CertSAM
casebook there will be a lunchtime session offering
advice. The day will include the following sessions:
Epilepsy: when the (usual) drugs dont work with
Dr Holger Volk
Antimicrobial usage in companion animal practice:
facts and moral dilemmas with Dr Susan Dawson
Case Reports competition presentations
sponsored by Vtoquinol
Venous thromboembolism: learning from a human
perspective with Dr Nandan Gautam
How to write a successful CertSAM casebook
with Jon Wray
Controversies surrounding treatment of aortic
thromboembolism with Dr Matt Beal
Feline acromegaly: separating facts from
assumptions with Stijn Niessen
Fees: Members 65, Non-members 95 (lunch
included if you register before 15 March 2010).
Annual membership: 25.
SAMSocs satellite event is sponsored by
Hills Pet Nutrition and Vtoquinol.
For details or
to book any
Satellite
Meeting
please
contact the
organiser
directly.
VCS
Veterinary Cardiovascular
Society
Venue: Hall 9, ICC
Booking contact:
Yolanda Martinez Pereira
Email: yolanda@zoologicalmedicine.com
Website: www.bsava.org.uk/vcs
Tel: +44 (0) 7743 947802
A
mericans are well known in this country for the
high quality of their dental work and so perhaps
it is not surprising that even their pets can
receive cutting edge orthodontic care. A leading
exponent of veterinary dentistry from the US has been
invited to pass on his skills to his British and European
colleagues at BSAVA Congress in Birmingham in April.
Among a series of presentations on different aspects
of oral surgery, Professor Bill Gengler of the University
of Wisconsin will outline the principles of orthodontics
to correct conditions resulting from malocclusions.
From man to beast
Appliances similar to those originally developed in
human dentistry are used with increasing frequency in
dogs on both sides of the Atlantic to create a more
regular bite. But in contrast with human orthodontics
these methods are never used simply for cosmetic
reasons. The orthodontic procedures that we do
perform are only for the health and comfort of the
animal, he explains.
As a member of the American Veterinary
Dental College, he uses these techniques to
prevent or to treat the painful consequences
of malocclusions, not to give the dogs
owners hope of success in shows. As a
group, we are very ethical and try not to
change the appearance so it will have an
advantage in the ring. We also encourage
owners to neuter animals that have
orthodontic treatment resulting from
hereditary defects.
Problems and solutions
Two defects which these methods are often used to
treat are linguoversion of the mandibular
canine teeth (or base narrow canines)
and rostroversion of the maxillary
canine tooth. The former can be a
very painful condition and occurs
mainly in long-nosed dogs such as
Labradors, German Shepherd Dogs
and Standard Poodles. Affected
animals have very narrow mandibles
and lower canine teeth that erupt
vertically, with the result that over time
Bit between
the teeth
at Congress
Dentistry lectures are always
especially popular at
Congress and even more
so when a leading expert
shares their skills
21-22 Congress.indd 21 19/1/10 08:53:09
22
|
companion
CONGRESS
GrapeVINe
Initial renal injury directly stimulates generation of angiotensin II (ANG II), and both decreased GFR and decreased
plasma oncotic pressure can lead to renin-angiotensin-aldosterone system (RAAS) upregulation. ANG II, and
aldosterone are both pro-inflammatory, and ANG II directly induces upregulation of transforming growth factor-
(TGF-). TGF- causes both tubular cell hypertrophy and increased synthesis of Type IV collagen. Excessive protein
reabsorption activates inflammatory genes, and causes upregulation of tubular-derived endothelin-1 (ET-1, a very
potent vasoconstrictor), monocyte chemoattractant protein-1 (CCL2, formerly known as MCP-1), and an
immunoregulatory cytokine called CCL5 (formerly known as RANTES). The presence of increased ET-1 in the
interstitium leads to ischemic damage, and induces the interstitial fibroblasts to proliferate and secrete increased
amounts of matrix. True to its (former) name, CCL2 attracts monocytes and other inflammatory mononuclear cells,
and CCL5 is chemotactic for T cells, eosinophils and basophils.
Increased interstitial amino acid transport is itself pro-inflammatory, and (combined with the cellular injury described
above, and the results of ANG-II and chemoattractant factor upregulation) eventually results in tubulointerstitial
nephritis with fibrosis and progressive loss of renal function. Magnitude of proteinuria usually determines severity of
inflammatory response, and fulminant, heavy proteinuria can cause inflammation severe enough to result in acute
tubular necrosis and uremia. If proteinuria can be slowed or halted, and the patient can be sustained (e.g., with
standard care or with dialysis), recovery from acute tubular necrosis and recovery from renal failure will often occur.
So no, its not just cosmetic or making the numbers look better proteinuria is pathological in and of itself, and
pathogenicity is proportional to magnitude.
Hope that helps.
Michael Riegger, DVM
Northwest Animal Clinic and Hospital, Albuquerque, NM
Good afternoon all,
Are there any double blinded comparisons of these situations?
Julie Fischer
Hi Michael
Double blinded comparisons of what (though most likely the answer is no)? The following study WAS blinded/
controlled (and had the participation of some folks who truly know their way around the kidney!), and looked at
enalapril use in dogs with GN, evaluating proteiniuria and progression in response to tx, but most of our data come
from (fairly copious) human and lab animal studies.
J Vet Intern Med. 2000 Sep-Oct;14(5):526-33
Effects of enalapril versus placebo as a treatment for canine idiopathic glomerulonephritis.
Grauer GF, Greco DS, Getzy DM, Cowgill LD, Vaden SL, Chew DJ, Polzin DJ, Barsanti JA
Michael Riegger
Thanx! =)
Julie Fischer
You bet. Glad youre looking for the evidence behind the rhetoric!
All content published courtesy of VIN with permission granted by each quoted VIN Member.
For more details about the Veterinary Information Network visit vin.com. As VIN is a global veterinary discussion forum not all diets,
drugs or equipment referred to in this feature will be available in the UK, nor do all drug choices necessarily conform to the
prescribing rules of the Cascade. Discussions may appear in an edited form.
This thread appears in an edited form. To read the full thread and access the links mentioned
visit http://www.vin.com/Link.plx?ID=4331686
Editors note:
Two familial renal diseases are recognised in the Soft-coated Wheaten Terrier.
1) A juvenile renal disease with pathologic changes suggestive of renal dysplasia.
2) An adult onset protein-losing nephropathy (PLN) either alone or in combination with a protein-losing enteropathy. Increased gut
permeability is suggested to lead to immune complex glomerulonephritis (membranoproliferative glomerulonephritis) that then progresses
to glomerular sclerosis and chronic interstitial nephritis (end-stage renal disease). Clinical findings are those expected in PLN (wt loss,
proteinuria, hypoalbuminaemia, hypercholesterolaemia progressing to PU/PD, azotaemia, hyperphosphataemia and non-regenerative
anaemia ) Hypertension and thromboembolism occasionally develop. The disease is progressive and associated with a poor prognosis.
Treatment is palliative.
24-26 GrapeVINe.indd 26 19/1/10 08:50:53
companion
|
27
PETSAVERS
Improving the health of the nations pets
P
etsavers is currently funding a study on
Establishing potential CSF markers of
degenerative myelopathy in the dog. The study
is headed by Professor T. James Anderson at the
University of Glasgow.
Professor Anderson describes his project:
Degenerative myelopathy (DM) (or chronic
degenerative radicuolomyelopathy, CDRM) is a
condition of the nervous system that affects mostly
older German Shepherd Dogs. A number of other
specific breeds may also be affected, in particular the
Chesapeake Bay Retriever and the Pembroke Corgi.
This slow degenerative condition of the central
nervous system leads to deterioration in hindlimb
action, with affected dogs becoming increasingly
unsteady and eventually unable to walk. Though,
fortunately, this condition appears not to be painful, it
is distressing for both patient and owner; and as
there is no cure, progression leads ultimately to
euthanasia. The frustration of the lack of an in life
diagnostic test is well recognised in veterinary
P
etsavers is looking for runners to take part in the British 10K London
Run. The run is a huge event and 27,000 runners took part last year
for many different charities. The route takes in many of Londons
landmarks including the London Eye and the Houses of Parliament. The
run is taking place on Sunday 11 July 2010, so there is plenty of time to
train and raise sponsorship. If you are interested in taking part please
contact Gene Waterhouse on g.waterhouse@bsava.com. Petsavers has
a limited number of places for the run, so if you are keen to take part please
get in touch soon to avoid disappointment.
Degenerative myelopathy project
Professor T. James Anderson
describes his Petsavers-funded
project on degenerative
myelopathy
practice, particularly as some other conditions may
have a similar clinical appearance.
A major step forward in the understanding of DM
has been made recently in the USA where it has been
revealed that affected dogs share a mutation of a
common gene. The affected gene is Superoxidase 1
(SOD1). SOD1 is involved in protecting cells from free
radicals, which are important in many destructive
pathways underlying disease. The contribution of
SOD1 to DM is now being actively investigated around
the world.
The current understanding is that the presence of
the mutation indicates that a dog has the potential to
develop the disease, but is not specifically
diagnostic. Other diseases, most importantly
degenerative disc disease, can cause similar
clinical signs and/or occur concurrently, but have a
potentially better outcome. Making the correct
diagnosis in an individual dog is important so the
best advice can be given.
This project will examine protein markers that
studies in a disease in man related to the SOD1
mutation amyotrophic lateral sclerosis (ALS)
suggest may be related to the presence of disease.
These disease markers comprise changes in a
group of serum and CSF proteins in ALS. The aim
is developing a test that will allow a diagnosis of DM to
be made with greater confidence.
Calling all runners
27 Petsavers.indd 27 19/1/10 08:35:19
26
|
companion
VIN
GrapeVINe
Initial renal injury directly stimulates generation of angiotensin II (ANG II), and both decreased GFR and decreased
plasma oncotic pressure can lead to renin-angiotensin-aldosterone system (RAAS) upregulation. ANG II, and
aldosterone are both pro-inflammatory, and ANG II directly induces upregulation of transforming growth factor-
(TGF-). TGF- causes both tubular cell hypertrophy and increased synthesis of Type IV collagen. Excessive protein
reabsorption activates inflammatory genes, and causes upregulation of tubular-derived endothelin-1 (ET-1, a very
potent vasoconstrictor), monocyte chemoattractant protein-1 (CCL2, formerly known as MCP-1), and an
immunoregulatory cytokine called CCL5 (formerly known as RANTES). The presence of increased ET-1 in the
interstitium leads to ischemic damage, and induces the interstitial fibroblasts to proliferate and secrete increased
amounts of matrix. True to its (former) name, CCL2 attracts monocytes and other inflammatory mononuclear cells,
and CCL5 is chemotactic for T cells, eosinophils and basophils.
Increased interstitial amino acid transport is itself pro-inflammatory, and (combined with the cellular injury described
above, and the results of ANG-II and chemoattractant factor upregulation) eventually results in tubulointerstitial
nephritis with fibrosis and progressive loss of renal function. Magnitude of proteinuria usually determines severity of
inflammatory response, and fulminant, heavy proteinuria can cause inflammation severe enough to result in acute
tubular necrosis and uremia. If proteinuria can be slowed or halted, and the patient can be sustained (e.g., with
standard care or with dialysis), recovery from acute tubular necrosis and recovery from renal failure will often occur.
So no, its not just cosmetic or making the numbers look better proteinuria is pathological in and of itself, and
pathogenicity is proportional to magnitude.
Hope that helps.
Michael Riegger, DVM
Northwest Animal Clinic and Hospital, Albuquerque, NM
Good afternoon all,
Are there any double blinded comparisons of these situations?
Julie Fischer
Hi Michael
Double blinded comparisons of what (though most likely the answer is no)? The following study WAS blinded/
controlled (and had the participation of some folks who truly know their way around the kidney!), and looked at
enalapril use in dogs with GN, evaluating proteiniuria and progression in response to tx, but most of our data come
from (fairly copious) human and lab animal studies.
J Vet Intern Med. 2000 Sep-Oct;14(5):526-33
Effects of enalapril versus placebo as a treatment for canine idiopathic glomerulonephritis.
Grauer GF, Greco DS, Getzy DM, Cowgill LD, Vaden SL, Chew DJ, Polzin DJ, Barsanti JA
Michael Riegger
Thanx! =)
Julie Fischer
You bet. Glad youre looking for the evidence behind the rhetoric!
All content published courtesy of VIN with permission granted by each quoted VIN Member.
For more details about the Veterinary Information Network visit vin.com. As VIN is a global veterinary discussion forum not all diets,
drugs or equipment referred to in this feature will be available in the UK, nor do all drug choices necessarily conform to the
prescribing rules of the Cascade. Discussions may appear in an edited form.
This thread appears in an edited form. To read the full thread and access the links mentioned
visit http://www.vin.com/Link.plx?ID=4331686
Editors note:
Two familial renal diseases are recognised in the Soft-coated Wheaten Terrier.
1) A juvenile renal disease with pathologic changes suggestive of renal dysplasia.
2) An adult onset protein-losing nephropathy (PLN) either alone or in combination with a protein-losing enteropathy. Increased gut
permeability is suggested to lead to immune complex glomerulonephritis (membranoproliferative glomerulonephritis) that then progresses
to glomerular sclerosis and chronic interstitial nephritis (end-stage renal disease). Clinical findings are those expected in PLN (wt loss,
proteinuria, hypoalbuminaemia, hypercholesterolaemia progressing to PU/PD, azotaemia, hyperphosphataemia and non-regenerative
anaemia ) Hypertension and thromboembolism occasionally develop. The disease is progressive and associated with a poor prognosis.
Treatment is palliative.
24-26 GrapeVINe.indd 26 19/1/10 08:50:53
companion
|
27
PETSAVERS
Improving the health of the nations pets
P
etsavers is currently funding a study on
Establishing potential CSF markers of
degenerative myelopathy in the dog. The study
is headed by Professor T. James Anderson at the
University of Glasgow.
Professor Anderson describes his project:
Degenerative myelopathy (DM) (or chronic
degenerative radicuolomyelopathy, CDRM) is a
condition of the nervous system that affects mostly
older German Shepherd Dogs. A number of other
specific breeds may also be affected, in particular the
Chesapeake Bay Retriever and the Pembroke Corgi.
This slow degenerative condition of the central
nervous system leads to deterioration in hindlimb
action, with affected dogs becoming increasingly
unsteady and eventually unable to walk. Though,
fortunately, this condition appears not to be painful, it
is distressing for both patient and owner; and as
there is no cure, progression leads ultimately to
euthanasia. The frustration of the lack of an in life
diagnostic test is well recognised in veterinary
P
etsavers is looking for runners to take part in the British 10K London
Run. The run is a huge event and 27,000 runners took part last year
for many different charities. The route takes in many of Londons
landmarks including the London Eye and the Houses of Parliament. The
run is taking place on Sunday 11 July 2010, so there is plenty of time to
train and raise sponsorship. If you are interested in taking part please
contact Gene Waterhouse on g.waterhouse@bsava.com. Petsavers has
a limited number of places for the run, so if you are keen to take part please
get in touch soon to avoid disappointment.
Degenerative myelopathy project
Professor T. James Anderson
describes his Petsavers-funded
project on degenerative
myelopathy
practice, particularly as some other conditions may
have a similar clinical appearance.
A major step forward in the understanding of DM
has been made recently in the USA where it has been
revealed that affected dogs share a mutation of a
common gene. The affected gene is Superoxidase 1
(SOD1). SOD1 is involved in protecting cells from free
radicals, which are important in many destructive
pathways underlying disease. The contribution of
SOD1 to DM is now being actively investigated around
the world.
The current understanding is that the presence of
the mutation indicates that a dog has the potential to
develop the disease, but is not specifically
diagnostic. Other diseases, most importantly
degenerative disc disease, can cause similar
clinical signs and/or occur concurrently, but have a
potentially better outcome. Making the correct
diagnosis in an individual dog is important so the
best advice can be given.
This project will examine protein markers that
studies in a disease in man related to the SOD1
mutation amyotrophic lateral sclerosis (ALS)
suggest may be related to the presence of disease.
These disease markers comprise changes in a
group of serum and CSF proteins in ALS. The aim
is developing a test that will allow a diagnosis of DM to
be made with greater confidence.
Calling all runners
27 Petsavers.indd 27 19/1/10 08:35:19
28
|
companion
PUBLICATIONS
Exotic Pets
the classic reborn
In the US, sugar gliders probably reached their
peak of popularity as a novelty pet about six years
ago. Therefore, most of those clients that are still
keeping them are among the knowledgeable and
enthusiastic minority who have often made
considerable sacrifices to adapt their home and
lifestyle to cope with the demands of these unusual
pets. Usually, these people are also generous in
providing advice and support for other less
experienced owners, Cathy says.
Increasing diversity
Pet marsupials were mentioned briefly in the previous
edition of the Manual, published in 2002, but with the
expansion in veterinary involvement in their care, they
now merit a complete chapter. Another currently
fashionable species, the African pygmy hedgehog (a
hybrid between the white-bellied hedgehog Atelerix
albiventris and the Algerian hedgehog A. algirus) is
also given a chapter to itself.
John Bonner speaks to the
editors of the new edition of the
original veterinary manual on
exotic pet care
Too sweet for their own good?
They sleep all day, they are noisy at night and they
bite. Their dietary needs are difficult to meet, they
scent mark around the home and they need huge
amounts of space to exercise. So they are certainly far
from being an ideal pet but they have the enormous
eyes of a nocturnal mammal, theyre undeniably cute
(as shown on our new cover), and theres the rub
They are sugar gliders (Petaurus breviceps),
small arboreal marsupials native to Australia and New
Guinea. They are also an increasingly popular pet
species in Britain, which is why they are included in a
chapter on pet marsupials in the updated and
expanded new edition of the BSAVA Manual of Exotic
Pets. Sugar gliders feature in the new Marsupials
chapter, written by Cathy Johnson-Delaney, a
specialist in exotic animal medicine based near
Seattle, who is a co-editor of the new fifth edition
which will be published in February 2010. Given the
difficulties that most people face in successfully
keeping sugar gliders, Cathy says she would
discourage any client contemplating buying one who
has not done their homework.
In principle, she is not averse to the notion of
keeping a pet marsupial, provided that it is the right
sort. She herself has a female Virginia opossum
(Didelphis virginiana), a species with a long and
relatively successful record of cohabitation with
humans. But in a 15-year career caring for sugar
gliders she knows that most of the problems that occur
in this and most other exotic species are a direct result
of ignorance and poor husbandry. As such they are
issues that veterinary practitioners are likely to be
asked to resolve and, like many of her colleagues, she
has personally taken responsibility for a large number
of pets discarded when their owners realise that they
cannot cope or they have lost interest.
The advent of the recent BSAVA Manual of Rodents
and Ferrets has led to some reorganisation of the
rodent content, including a new chapter devoted to
chinchillas, degus and duprasi. There are also
completely new chapters on some groups that will be
professionally challenging to all but the most
28-29 Publications.indd 28 19/1/10 08:42:54
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PUBLICATIONS
experienced exotics practitioner, such as crocodilians
and ratites (ostriches, rheas and emus).
One of the more familiar species, the ferret, is
grouped together with two closely related mustelid
groups, otters and skunks. As with some of the
species already mentioned, otters may not be a
regular visitor to the suburban veterinary consult room,
and long may that remain the case. But it is important
to include them, because species like the Asian
short-clawed otter (Aonyx cinerea) are active during
the day and are therefore a favourite for small
zoological collections. So, practitioners may well be
called out to administer preventive healthcare, in the
form of distemper vaccinations, and to treat their
common ailments, such as urolithiasis.
EXOTIC PETS COVERED
Mice, rats, hamsters and gerbils; Guinea pigs,
chinchillas, degus and duprasi; Chipmunks and
prairie dogs; Rabbits; Marsupials; Ferrets, skunks
and otters; African pygmy hedgehogs; Primates
callitrichids, cebids and lemurs; Cage and aviary
birds; Racing pigeons; Birds of prey; Ostriches,
emus and rheas; Crocodilians; Tortoises and
turtles; Lizards; Snakes; Frogs and toads;
Salamanders, axolotls and caecilians; Freshwater
ornamental fish; Marine fish; Invertebrates
User-friendly
As with all BSAVA Manuals, the new Exotic Pets is
intended to be a book that becomes dog-eared with
regular use, rather than something that decorates a
shelf for months on end. The editors have spent a
considerable amount of time checking and amending
the content and format, so that it is possible for the
user to have confidence that they will quickly find what
they are looking for during a consultation.
The idea is that each chapter should be
presented in a consistent and logical way. We have
organised each one so that it begins with a brief
explanation of the natural history of the particular
species or group, and goes on to deal with their
anatomy, physiology, nutrition and husbandry. For the
less experienced practitioner, we also include advice
on how they should be handling that animal before
describing the overall diagnostic
approach and the diseases that
they are most likely to encounter.
We hope that this Manual will
give a vet everything they need
to know in order to approach an
unfamiliar species in a
sensible way and for them to
be able to give an owner good
advice on how to look after it,
Anna explains.
Some species included in the manual may no
longer be strictly classified as exotics rabbits, for
example, long ago entered the mainstream of
veterinary practice. However, co-editor Anna Meredith
from the University of Edinburgh veterinary school,
says it was decided to maintain a comprehensive list
of minor species in the Manual, so that it remains the
go-to publication in the field.
Such have been the advances in knowledge on
rabbits that there is a separate BSAVA Manual devoted
to them. But the condensed information presented in
Exotic Pets will provide a busy practitioner with pretty
well everything they need to know during the course of
a consultation. Any further research can be carried out
later when the practitioner has time to check in the
more specialised volume.
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28
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PUBLICATIONS
Exotic Pets
the classic reborn
In the US, sugar gliders probably reached their
peak of popularity as a novelty pet about six years
ago. Therefore, most of those clients that are still
keeping them are among the knowledgeable and
enthusiastic minority who have often made
considerable sacrifices to adapt their home and
lifestyle to cope with the demands of these unusual
pets. Usually, these people are also generous in
providing advice and support for other less
experienced owners, Cathy says.
Increasing diversity
Pet marsupials were mentioned briefly in the previous
edition of the Manual, published in 2002, but with the
expansion in veterinary involvement in their care, they
now merit a complete chapter. Another currently
fashionable species, the African pygmy hedgehog (a
hybrid between the white-bellied hedgehog Atelerix
albiventris and the Algerian hedgehog A. algirus) is
also given a chapter to itself.
John Bonner speaks to the
editors of the new edition of the
original veterinary manual on
exotic pet care
Too sweet for their own good?
They sleep all day, they are noisy at night and they
bite. Their dietary needs are difficult to meet, they
scent mark around the home and they need huge
amounts of space to exercise. So they are certainly far
from being an ideal pet but they have the enormous
eyes of a nocturnal mammal, theyre undeniably cute
(as shown on our new cover), and theres the rub
They are sugar gliders (Petaurus breviceps),
small arboreal marsupials native to Australia and New
Guinea. They are also an increasingly popular pet
species in Britain, which is why they are included in a
chapter on pet marsupials in the updated and
expanded new edition of the BSAVA Manual of Exotic
Pets. Sugar gliders feature in the new Marsupials
chapter, written by Cathy Johnson-Delaney, a
specialist in exotic animal medicine based near
Seattle, who is a co-editor of the new fifth edition
which will be published in February 2010. Given the
difficulties that most people face in successfully
keeping sugar gliders, Cathy says she would
discourage any client contemplating buying one who
has not done their homework.
In principle, she is not averse to the notion of
keeping a pet marsupial, provided that it is the right
sort. She herself has a female Virginia opossum
(Didelphis virginiana), a species with a long and
relatively successful record of cohabitation with
humans. But in a 15-year career caring for sugar
gliders she knows that most of the problems that occur
in this and most other exotic species are a direct result
of ignorance and poor husbandry. As such they are
issues that veterinary practitioners are likely to be
asked to resolve and, like many of her colleagues, she
has personally taken responsibility for a large number
of pets discarded when their owners realise that they
cannot cope or they have lost interest.
The advent of the recent BSAVA Manual of Rodents
and Ferrets has led to some reorganisation of the
rodent content, including a new chapter devoted to
chinchillas, degus and duprasi. There are also
completely new chapters on some groups that will be
professionally challenging to all but the most
28-29 Publications.indd 28 19/1/10 08:42:54
companion
|
29
PUBLICATIONS
experienced exotics practitioner, such as crocodilians
and ratites (ostriches, rheas and emus).
One of the more familiar species, the ferret, is
grouped together with two closely related mustelid
groups, otters and skunks. As with some of the
species already mentioned, otters may not be a
regular visitor to the suburban veterinary consult room,
and long may that remain the case. But it is important
to include them, because species like the Asian
short-clawed otter (Aonyx cinerea) are active during
the day and are therefore a favourite for small
zoological collections. So, practitioners may well be
called out to administer preventive healthcare, in the
form of distemper vaccinations, and to treat their
common ailments, such as urolithiasis.
EXOTIC PETS COVERED
Mice, rats, hamsters and gerbils; Guinea pigs,
chinchillas, degus and duprasi; Chipmunks and
prairie dogs; Rabbits; Marsupials; Ferrets, skunks
and otters; African pygmy hedgehogs; Primates
callitrichids, cebids and lemurs; Cage and aviary
birds; Racing pigeons; Birds of prey; Ostriches,
emus and rheas; Crocodilians; Tortoises and
turtles; Lizards; Snakes; Frogs and toads;
Salamanders, axolotls and caecilians; Freshwater
ornamental fish; Marine fish; Invertebrates
User-friendly
As with all BSAVA Manuals, the new Exotic Pets is
intended to be a book that becomes dog-eared with
regular use, rather than something that decorates a
shelf for months on end. The editors have spent a
considerable amount of time checking and amending
the content and format, so that it is possible for the
user to have confidence that they will quickly find what
they are looking for during a consultation.
The idea is that each chapter should be
presented in a consistent and logical way. We have
organised each one so that it begins with a brief
explanation of the natural history of the particular
species or group, and goes on to deal with their
anatomy, physiology, nutrition and husbandry. For the
less experienced practitioner, we also include advice
on how they should be handling that animal before
describing the overall diagnostic
approach and the diseases that
they are most likely to encounter.
We hope that this Manual will
give a vet everything they need
to know in order to approach an
unfamiliar species in a
sensible way and for them to
be able to give an owner good
advice on how to look after it,
Anna explains.
Some species included in the manual may no
longer be strictly classified as exotics rabbits, for
example, long ago entered the mainstream of
veterinary practice. However, co-editor Anna Meredith
from the University of Edinburgh veterinary school,
says it was decided to maintain a comprehensive list
of minor species in the Manual, so that it remains the
go-to publication in the field.
Such have been the advances in knowledge on
rabbits that there is a separate BSAVA Manual devoted
to them. But the condensed information presented in
Exotic Pets will provide a busy practitioner with pretty
well everything they need to know during the course of
a consultation. Any further research can be carried out
later when the practitioner has time to check in the
more specialised volume.
companion
|
29
28-29 Publications.indd 29 19/1/10 08:42:58
30
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W
hat an eventful year it has been for WSAVA!
The WSAVA Congress held in So Paulo was
a great success, with over 3500 delegates
making it the biggest WSAVA World Congress ever
staged. It was always going to be a huge party and the
Saturday night event had the delegates dancing and
partying until the early hours of the morning! The
education programme was superb and great credit
must go to Drs Wanderson Ferrara, Saliem Sayeed
and Marco Gioso and their committees for their work
in staging the Congress and setting such a high
standard for the future. Talking of which, the
Assembly voted to take the 2013 Congress to
Christchurch, New Zealand, and we are already
working hard with them to ensure our ongoing
Congress success. We are immensely grateful to
our Prime Congress Sponsor, Hills Pet Nutrition, for
all the help given to WSAVA as we aim to set the
highest standards in veterinary education.
Change and hard work on the Board
There have been changes to the WSAVA Board. We
were saddened that Dr Luis Tello resigned because of
time commitment pressures, but I am really pleased
that he has been able to continue to look after the
WSAVA CE programme in Latin America. His deep
knowledge of the area and his many friends and
contacts mean that the programme runs very smoothly
and I am very grateful for all the help he gives. He was
replaced by Professor Peter Ihrke who I am sure
needs no introduction. He is currently Vice President
and we will be looking to him for his wisdom and
knowledge of international committee work.
Dr Veronica Leong also joined the Board to add
greater depth to a committee which is struggling under
an expanding workload. Her expertise in marketing will
be invaluable in helping us to expand our PR portfolio.
Dr Sheehan has continued to work hard in
developing the treasury, and is now faced with the task
of working with the new Canadian accountants and
instituting another new system that will hopefully be
stable for many years to come as the WSAVA settles
into its new incorporation as a Canadian Registered
not-for-profit company.
Professor Jolle Kirpensteijn and we must
congratulate him on being elected a full Professor
in the University of Utrecht has been working
tirelessly on future WSAVA Congresses and
developing sponsorship opportunities with our
commercial partners. The Assembly voted in So
Paulo to form a Congress Steering Committee to
look into the current structure and future development
of the WSAVA Congress Drs Kirpensteijn and
Sheehan have worked tirelessly to form this
committee and one of its first tasks will be to
examine bids for the 2014 Congress.
Hon. Secretaries are always spoken of as hard
working and Dr Walt Ingwersen is no exception. As
well as his normal duties, he has been the lynchpin in
the negotiations with the Canadian authorities and we
are grateful to him and his wife June for all their hard
work. June will also be developing the prototype
WSAVA secretariat which will function separately to,
but under the jurisdiction of, the Honorary Secretary.
Dr Brian Romberg has not been relaxing after his
tenure as President, he has been working on the
formation of the WSAVA Foundation, again as a
registered company based in Canada, and he will be
submitting his report on this exciting project in Geneva.
What a year!
David Wadsworth, WSAVA President,
reports on an eventful year for the Association
30-32 WSAVA News.indd 30 19/1/10 08:45:45
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31
WSAVA NEWS
T
he official welcome reception will take place
on 2 June at Palexpo and be followed by a
Swiss Apero in the exhibition hall.
The world famous Geneva Fountain will form the
backdrop for the Gala Dinner on 3 June. Participants
will leave from Downtown Geneva on a boat for a
relaxing one-hour cruise on Lake Geneva. A welcome
drink will be served on board as the last light of the
day reflects on the Lake. Following the boat trip the
gala dinner will be served with a musical
accompaniment.
Geneva 2010:
update
To keep up with the latest progress and
learn more about One Medicine, please
join us at the WSAVA World Congress in
Geneva on 25 June 2010
The Swiss Evening Party on 4 June will allow
delegates to discover a historical location of
Geneva: the Btiment des Forces Motrices (BFM).
A former hydro-electrical facility built on the Rhne
River, the BFM will be converted into a giant gala
room to make this a unique event.
The Scientific Programme is now available
look for more information and print your
own copy at www.wsava2010.org
M
i
h
a
i
-
b
o
g
d
a
n
L
a
z
a
r
|
D
r
e
a
m
s
t
i
m
e
.
c
o
m
30-32 WSAVA News.indd 32 19/1/10 08:46:05
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33
THE companion INTERVIEW
Carmel
Mooney
Q
What was your family life like and was there
any history of veterinary medicine?
A
My one brother and I share a birthday he
was four and really wanted a Dinky car, but got
me instead, so he has never really forgiven me.
My father was a civil servant specialising in pensions
and taxes and my mother (not unexpectedly) was a
full-time housewife. I grew up in DunLaoghaire,
Co Dublin, a small town south of the city and went to
both primary and secondary school locally
St Joseph of Cluny. After school I studied veterinary at
T
he official welcome reception will take place
on 2 June at Palexpo and be followed by a
Swiss Apero in the exhibition hall.
The world famous Geneva Fountain will form the
backdrop for the Gala Dinner on 3 June. Participants
will leave from Downtown Geneva on a boat for a
relaxing one-hour cruise on Lake Geneva. A welcome
drink will be served on board as the last light of the
day reflects on the Lake. Following the boat trip the
gala dinner will be served with a musical
accompaniment.
Geneva 2010:
update
To keep up with the latest progress and
learn more about One Medicine, please
join us at the WSAVA World Congress in
Geneva on 25 June 2010
The Swiss Evening Party on 4 June will allow
delegates to discover a historical location of
Geneva: the Btiment des Forces Motrices (BFM).
A former hydro-electrical facility built on the Rhne
River, the BFM will be converted into a giant gala
room to make this a unique event.
The Scientific Programme is now available
look for more information and print your
own copy at www.wsava2010.org
M
i
h
a
i
-
b
o
g
d
a
n
L
a
z
a
r
|
D
r
e
a
m
s
t
i
m
e
.
c
o
m
30-32 WSAVA News.indd 32 19/1/10 08:46:05
companion
|
33
THE companion INTERVIEW
Carmel
Mooney
Q
What was your family life like and was there
any history of veterinary medicine?
A
My one brother and I share a birthday he
was four and really wanted a Dinky car, but got
me instead, so he has never really forgiven me.
My father was a civil servant specialising in pensions
and taxes and my mother (not unexpectedly) was a
full-time housewife. I grew up in DunLaoghaire,
Co Dublin, a small town south of the city and went to
both primary and secondary school locally
St Joseph of Cluny. After school I studied veterinary at