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SCIENCE ELECTIVE 2
(Sci2e-PhyChem)
Submitted by:
CASURRA, Janine Erica
II- St. Peter
Submitted to:
Mrs. Genevieve Lopez
Sci2e-Teacher
FOREIGN CHEMIST
Francis William Aston
Emil Abderhalden
Abderhalden is known for a blood test for pregnancy, a test for cystine in urine, and for
explaining the Abderhalden-Kaufmann-Lignac syndrome, a recessive genetic condition. He did
extensive work in the analysis of proteins, polypeptides, and enzymes. His Abwehrfermente
("defensive enzymes") theory stated that immunological challenge will induce production of
proteases. This was seemingly "proven" by many collaborators in Europe, although attempts to
verify the theory abroad failed. The pregnancy test was determined to be unreliable a few years
after its inception. In late 1912 Abderhalden's "defensive ferments reaction test" was applied to
the differential diagnosis of dementia praecox from other mental diseases and from normals by
Stuttgart psychiatrist August Fauser (1856-1938), and his miraculous claims of success were
soon replicated by researchers in Germany and particularly in the United States. However,
despite the worldwide publicity this "blood test for madness" generated, within a few years the
"Abderhalden-Fauser reaction" was discredited and only a handful of American psychiatric
researchers continued to believe in it. Certainly by 1920 the test was all but forgotten in the USA.
Abderhalden's reputation continued to grow in Germany, however, where collaborators managed
to "replicate" his results, usually by simply repeating experiments until they succeeded and
discarding the negative results. As Abderhalden was seen as the founder of scientific
biochemistry in Germany, questioning his work could harm one's career, as Leonor Michaelis
discovered in the mid-1910s; by 1922, Michaelis' reputation was so tarnished that he had to leave
the country to embark on an outstanding career of scientific success abroad. Otto Westphal later
called Abderhalden's Abwehrfermente work "a fraud from beginning to end". Abderhalden's work
was strongly ideologically slanted: his theory was put to use for human experiments by Otmar von
Verschuer and Josef Mengele to develop a blood test for separating "Aryan" from "non-Aryan"
individuals. While Abderhalden himself did not take part in this work, evidence suggests that he
was instrumental in ideologically streamlining the German Academy of Natural Scientists
Leopoldina by having the Jewish members purged and replaced by Nazi sycophants. Despite of
his theories being rejected as early as the mid-1910s, Abderhalden still loomed large as a kind of
"father figure" in parts of the German scientific community and only by Deichmann and Müller-
Hill's scathing 1998 review, the entire extent of the rejection was revealed. It must be noted,
however, that in Abderhalden's days, the science of immunology was all but non-existent. That
his experiments indeed seemed to "work" on occasion was probably due to immunoprecipitation.
The crucial difference between this and Abderhalden's theory is that the former is an effect of
antibodies, whereas the fictitious Abwehrfermente were presumed to be proteases; a difference
that has large implications for biochemistry and immunology. The most comprehensive analysis
of the issue as to whether Abderhalden was simply grossly mistaken or perpetuated deliberate
fraud can be found in Kaasch.
Leo Baekeland
Stoichiometry contribution
Jeremias Benjamin Richter's work had little impact until 1802, when it was summarized
by Fischer in terms of tables, such as the one below. According to this table, it takes 615 parts by
weight of magnesia to neutralize either 1000 parts by weight of sulfuric acid or 1405 parts by
weight of nitric acid. In the early literature on the subject, these weights were referred to as
combining weights.