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SUMMARY
Cell theory
– somatic cells and sex cells
Cell structures/ functions
– plasma membrane
transport mechanisms
– cytoplasm
– cytoplasmic organelles
CELL THEORY
The cell is the basic structural and functional unit
of all living organisms;
– therefore, all organisms are composed of one or more
cells
Cytoplasm
– nucleus
– organelles
– intracellular fluid (cytosol)
– ions, proteins, stored nutrients, waste
products
PLASMA MEMBRANE
Consistency of olive
oil
dynamic
selectively
permeable
lipid bilayer (double
layer)
PLASMA MEMBRANE
PLASMA MEMBRANE
LIPID BILAYER
Phospholipids:
– hydrophilic heads (face outward)
– hydrophobic tails (face towards
eachother)
Cholesterol:
– helps stabilize membrane
Proteins (1/2 the mass of the
membrane):
– transport
– receptors
– cell recognition
– connect cells
MEMBRANE PROTEINS
MOVEMENT ACROSS PLASMA
MEMBRANE
Passive transport:
– down concentration gradient
– simple diffusion
– facilitated diffusion
– osmosis
– filtration
Active transport:
– requires atp
– vesicular transport:
– larger molecules
MOVEMENT ACROSS PLASMA
MEMBRANE
– Active transport:
requires ATP
Passive Transport
DIFFUSION
The spreading
of particles with
a movement
toward uniform
distribution of
particles.
PASSIVE TRANSPORT
Simple diffusion
– diffusion directly through lipid bilayer
non-polar substances (ex. 02, co2, lipids)
exception: water
ex. lungs/ capillaries (o2, co2)
PASSIVE TRANSPORT
Facilitated diffusion
Secondary:
– ATP use is indirect
– usually co-transporting with a substance which
is flowing down its concentration gradient
– eg. na+ and glucose in digestive tract
VESICULAR TRANSPORT
(BULK TRANSPORT)
Exocytosis:
– products of cell
leave via vesicles
– ex. hormones,
neurotransmitters,
wastes, mucus
VESICULAR TRANSPORT
Endocytosis:
Makesproteins for
plasma membrane
SMOOTH ER (SER)
Production of
phospholipids and
cholesterol
synthesis of steroid
based hormones
produces enzymes
– glycogen breakdown
– detoxification (especially
in liver)
specialized ser in
skeletal/ cardiac muscle
for calcium storage
ENDOPLASMIC RETICULUM
GOLGI APPARATUS
Vesicles break off of rer
and fuse with golgi
golgi modifies and
to:
– be secreted from cell
– incorporated into plasma
membrane
– become lysosomes full of
digestive enzymes
GOLGI APPARATUS
GOLGI APPARATUS
LYSOSOMES
Vesicles containing
digestive enzymes (can
digest almost all
biological molecules)
acidic interior
abundant in
phagocytes
LYSOSOMES
Functions:
– digest products of endocytosis
(bacteria, viruses, toxins)
– breakdown non-functional
organelles
– breakdown nonuseful tissues
(webs of fingers/ toes; uterine
lining (menses))
– breakdown of bone to release
calcium into blood
ENDOMEMBRANE SYSTEM
PEROXISOMES
Contain oxidases and
catalases
Detox etoh (alcohol)
Neutralize free radicals
– aerobic respiration
2 membranes (inner &
outer)
– cristae = folds of inner
membrane
– space within inner membrane
= matrix (gel)
MITOCHONDRIA
RIBOSOMES
Siteof protein
synthesis
two types
– free in cytosol
(unattached)
make proteins that
function in the cytosol
– membrane bound
(attached to
endoplasmic reticulum)
make proteins either for
cell membrane or export
RIBOSOMES
CYTOSKELETON
Support cellular structure
and shape
cell movement
3 components
– microfilaments
– intermediate filaments
– microtubules
cellular extensions
– cilia
– flagella
CYTOSKELETON
Microfilaments:
– thinnest
– help to determine
cell’s shape
– help with
movement patterns
(muscle
contraction/ cell
division)
CYTOSKELETON
INTERMEDIATE
FILAMENTS:
– MIDDLE IN SIZE
– RESIST PULLING
FORCES EXERTED ON
CELL
MICROTUBULES:
– LARGEST
– DETERMINE OVERALL
SHAPE OF CELL
– DETERMINE
DISTRIBUTION OF
ORGANELLES
CELLULAR EXTENSIONS
MADE OF
CYTOSKELETON
CILIA:
– ON EXPOSED
SURFACES OF CERTAIN
CELLS
– MOVE SUBSTANCES
ACROSS CELL SURFACE
(ie. RESPIRATORY
TRACT)
FLAGELLA:
– LONGER
– MOVE CELL ITSELF
– ex. SPERM
CILIA
Control center:
– directs cells activities
NUCLEUS
– DNA direct’s
synthesis of all
proteins
proteins direct
synthesis of other
molecules
most cells have only
one
– exceptions:
multinucleate:
skeletal muscles
anucleate: rbc’s
NUCLEUS
Nuclear membrane
– double membrane continuous
with RER
– nuclear pores (regulate
entry/ exit of large
molecules)
ex. release of RNA for protein
synthesis
ex. entry of ribosomal proteins
chromatin:
– genetic material
nucleolus:
– site where ribosomal
subunits are assembled
NUCLEUS
Chromatin:
– DNA
– will form into
chromosomes
during cell
reproduction
– all cells have the
same genetic code…
cell
specialization: in
each type of cell,
some genes are on
and some are off
NUCLEUS
Interphase
CELL LIFE CYCLE
– most of the cells life
(hours, days, lifetime)
– everyday activities
occuring
– dna duplication occurs at
the end of this phase
– dna is in the form of
chromatin
Mitosis
– cell division
– dna is in the form of
chromasome