Calcium & Cell Function

J une 1 6, 2014
Meli Nassau Beach
Nassau, Bahamas

Co-Organizers:
Aldebaran M. Hofer
Harvard Medical School
Boston, MA

Stefan Feske
New York University School of Medicine
New York, NY

SUNDAY, JUNE 01, 2014

4:00PM 9:00PM Conference Registration

6:00PM 7:00PM FASEB Opening Reception

7:00PM 8:30PM Dinner

8:30PM 8:45PM Ole Petersen, Cardiff University
Introduction to Keynote Lecture

8:45PM 10:00PM
KEYNOTE LECTURE
Tullio Pozzan, University of Padova
Measuring and manipulating organelle Ca
2+
in living cells: a 25
years long project

Monday, June 02, 2014


7:30AM 9:00AM Breakfast

Session 1:
9:00AM 12:15PM
New Technologies for Studying Calcium Signaling
Chair: J enny J . Yang, Georgia State University

9:00AM 9:15AM Welcome from FASEB

9:15AM 9:45AM J in Zhang, The J ohns Hopkins University School of Medicine
Spatiotemporal Regulation of Calcineurin Activity in Living Cells



9:45AM 10:15AM


Takanari Inoue, The J ohns Hopkins University School of Medicine
Probing Ca
2+
signaling inside primary cilia with molecular sensors
and actuators
10:15AM 10:30 AM J udith Stolwijk, SUNY
Calcium signals in the control of endothelial barrier function

10:30AM 11:00AM Group photo & FASEB Sponsored Coffee Break

11:00AM 11:30AM Takeharu Nagai, Osaka University
Genetically-encoded tools to optically control and image calcium
dynamics

11:30AM 11:45AM J iahui Wu, University of Alberta
"An expanded Ca
2+
indicator toolbox with various hues and
affinities"

11:45AM 12:15PM J enny J . Yang, Georgia State University
Visualizing Calciomics and designing calcium sensors with fast
kinetics

12:15PM 1:15PM Lunch

Free Afternoon

Session 2:
4:00PM 6:45PM
Mitochondrial Calcium Signaling
Chair: Gyorgy Hajnczky, Thomas J efferson University

4:00PM 4:30PM Robert Balaban, NHLBI
The Effects of Calcium on the Oxidative Phosphorylation Cascade
in Muscle Mitochondria

4:30PM 5:00PM Brian ORourke, J ohns Hopkins
Cardiac Mitochondria, Calcium, and Arrhythmias

5:00PM 5:15PM Tim Knig, University of Cologne
MAIP1 links mitochondrial Ca
2+
homeostasis to the m-AAA
protease & neurodegeneration

5:15PM 5:30PM Break

5:30PM 5:45PM Agustin Guerrero-Hernandez, CINVESTAV
Role of calcium movement between endoplasmic reticulum and
mitochondria in triggering cerebellar granule neuron apoptosis

5:45PM 6:15PM Mei-ling J oiner, University of Iowa
Mediators of the Mitochondrial Calcium Signal

6:15PM 6:45PM Sarino Rizzuto, University of Padova
Molecular Identity of the Mitochondrial Ca
2+
Uniporter

7:00PM 8:00PM Dinner

8:00PM 10:00PM

POSTER SESSION


Tuesday, June 03, 2014


7:30AM 9:00AM Breakfast

Session 3
9:00AM 12:00PM
Calcium in Disease Processes
Chair: Stefan Feske, New York University School of Medicine


9:00 AM 9:30AM Alexei Tepikin, University of Liverpool
Calcium signalling mechanisms in pancreatitis and pancreatic
cancer

9:30AM 10:00AM Andrea Fleig, University of Hawaii
TRPM7 and disease

10:00AM 10:15AM Amelia Brennan, Peter MacCallum Cancer Centre
A novel role for calcium in cytotoxic lymphocyte perforin
proteostasis

10:15AM 10:45AM FASEB Sponsored Coffee Break

10:45AM 11:15AM Anant Parekh, University of Oxford
CRAC channels and allergy

11:15AM 11:30AM Rodrigo Lacruz, New York University College of Dentistry
"Evidence for CRAC channel activity in dental enamel formation
and implications for oral health and disease"

11:30AM 12:00PM Barbara Ehrlich, Yale University
Polycystic Kidney Disease

12:00PM 1:30PM

Lunch

Free Afternoon

Session 4:
4:00PM 6:45PM
Cell Biology of Calcium Signaling
Chair: Don Gill, Pennsylvania State University

4:00PM 4:30PM David Yule, University of Rochester
Calcium Signaling and Pancreatic Stellate Cell Function"

4:30PM 5:00PM Tobias Meyer, Stanford University
A polarized Ca
2+
, diacylglycerol and STIM1 signaling system
regulates directed cell migration

5:00PM 5:15PM J ulia Gerasimenko, Cardiff University
Both ryanodine receptors and two-pore channels are involved in
NAADP-mediated intracellular Ca
2+
release in pancreatic acinar
cells

5:15PM 5:30PM Break




5:30PM 5:45PM Damien OHalloran, The George Washington University
Sodium Calcium exchangers in neural circuit assembly

5:45PM 6:15PM Khaled Machaca, Weill Cornell Medical College Qatar
miRNA regulation of STIM1 expression

6:15PM 6:45PM M. Fatima Leite, Federal University of Minas Gerais
Nuclear calcium and cell proliferation


7:00PM 8:00PM Dinner

8:00PM 10:00PM

POSTER SESSION

8:00PM 10:00PM

Meet the Experts (runs concurrently with Poster Session)


Wednesday, June 04, 2014

7:30AM 9:00AM Breakfast

Session 5
9:00AM 12:00PM
Store-operated Calcium Entry
Chair: J im Putney, NIEHS

9:00AM 9:30AM Patrick Hogan, La J olla Institute for Allergy and Immunology
STIM1 triggers a gating rearrangement at the extracellular mouth
of the ORAI1 channel

9:30AM 10:00AM Murali Prakriya, Northwestern University
Regulation of neurogenesis by store operated CRAC channels
10:00AM 10:15AM Rainer Schindl, J ohannes Kepler University Linz
Novel trans-membrane mutation switches Orai1 to a constitutively
active and Ca
2+
selective channel

10:15AM 10:45AM FASEB Sponsored Coffee Break


10:45AM 11:00AM Ivan Bogeski, University of the Saarland
The role of ORAI channels and their interplay with NADPH oxidase
2 in bacterial peptide-induced innate immune responses

11:00AM 11:30AM Rich Lewis, Stanford University
"Crosstalk between CRAC channels and the cytoskeleton at the
immune synapse"

11:30AM 12:00PM Stefan Feske, New York University School of Medicine
CRAC channels in immunity to infection and tumors

12:00PM 1:00PM Lunch

Free Afternoon




Session 6:
4:00PM 6:45PM
Calcium and pathogen / symbiont interactions
Chair: Shmuel Muallem, NIDCR

4:00PM 4:30PM Nicolas Demaurex, University of Geneva, Switzerland
STIM1 and junctate mediate localized calcium signals that boost
phagocytosis

4:30PM 5:00PM L. David Sibley, Washington University
Calcium regulated secretion in the protozoan parasite
Toxoplasma"

5:00PM 5:15PM J oseph M. Hyser, Baylor College of Medicine
Store-operated and Voltage-activated Calcium Channels are
Activated by Rotavirus NSP4-mediated Viroporin Activity through
Release of ER Calcium Stores

5:15PM 5:30PM Break

5:30PM 5:45PM Celia Garcia, University of So Paulo
Calcium signaling in malarial parasites

5:45PM 6:15PM Silvia Moreno, Center for Tropical and Emerging Diseases,
University of Georgia
Calcium and the lytic cycle of the apicomplexan parasite
Toxoplasma gondii

6:15PM 6:45PM Giles E. Oldroyd, J ohn Innes Centre
Calcium encoding and decoding during symbiotic signalling of
plants

6:45PM 7:00PM BUSINESS MEETING

7:00PM 8:00PM Dinner

8:00PM 10:00PM

POSTER SESSION

8:00PM 10:00PM

Meet the Experts (runs concurrently with Poster Session)

Thursday, June 05, 2014


7:30AM 9:00AM Breakfast

Session 7
9:00AM 12:00PM
TRPs and other calcium channels
Chair: Indu Ambudkar, NIDCR

9:00AM 9:30AM Mark T. Nelson, University of Vermont
AKAP150-dependent cooperative TRPV4 channel gating is central
to endothelium-dependent vasodilation and is disrupted in
hypertension

9:30AM 10:00AM David Clapham, Harvard Medical School
Calcium in primary cilia

10:00AM 10:15AM Natalia Prevarskaya, INSERM
"Role of calcium channels in skin homeostasis


10:15AM 10:45AM FASEB Sponsored Coffee Break

10:45AM 11:15AM Diana Bautista, UC Berkeley
Roles of Orai1 and TRPA1 in chronic itch

11:15AM 11:45AM Elena Oancea, Brown University
TRPA1 channels mediate the response of human melanocytes to
UVA and UVB radiation

12:00PM 1:00PM Lunch
(Boxed lunches available in lobby for group activity)


Free Afternoon

12:00PM 6:00PM Optional Organized Group Activity: SNORKELING TRIP



6:00PM 7:00PM Dinner



Session 8:
7:00PM 10:00PM
Intracellular Ca
2+
Release and Endnote Lecture
Chair: Andrew Thomas, UMDNJ

7:00PM 7:30PM J . Kevin Foskett, University of Pennsylvania
InsP
3
receptor Ca
2+
release channels in neurological disease

7:30PM 8:00PM Andreas Guse, University Medical Center Hamburg-Eppendorf
Calcium release by the 2
nd
messengers NAADP, cADPR and
ADPR

8:00PM 8:15PM Geert Bultynck, KU Leuven
Anti-apoptotic Bcl-2/Bcl-XL proteins target and inhibit ryanodine
receptors

8:15PM 8:30PM Ronghua ZhuGe, University of Massachusetts Medical School
New Insight into the Bitter Tastant-induced Bronchodilation

8:30PM 8:45PM Break

8:45PM 9:00PM David Clapham, Harvard Medical School
Introduction to Endnote Lecture

9:00PM 10:00PM
ENDNOTE LECTURE
Richard W. Tsien, New York University School of Medicine
Long Distance Ca
2+
Signaling via Private Line












END OF CONFERENCE
For additional information contact:

FASEB Science Research Conferences
9650 Rockville Pike
Bethesda, MD 20814

www.faseb.org/src


Friday, June 06, 2014

7:30AM 9:00AM Breakfast

9:00AM Departure and Box Lunches