ceutiques Grand Public Association of the European Self-Medication Industry Europischer Verband der Arzneimittel-Hersteller 1964-2014 5 years 2 aesgp.eu Table of contents Message from the President 3 Message from the Director General 4 History 5 Mission 12 Policy recommendations 13 AESGP Members 14 How AESGP works 16 Stakeholder collaboration 18 Publications 20 Annual Meetings 24 Past Presidents and Directors General 26 AESGP Euro OTC News 27 50 Years AESGP 3 Message from the President The year 2014 is an important milestone in the history of the Association of the European Self-Medication Industry (AESGP); its 50th anniversary. Initiated in the early 1960s by just three companies, the association has grown to become the official voice of the consumer healthcare industry in Europe. It represents national associations and directly or indirectly - through the national associations - more than 2000 companies producing non- prescription medicines, food supplements and self-care medical devices AESGP celebrates its 50th anniversary having achieved the key objectives set at the time of its establishment: There is a recognised and established distinction between prescription and no-prescription medicines across Europe Communication with citizens and the provision of information through advertising are allowed Free pricing for manufacturers is the standard practice in nearly all European countries, with European Union policy initiatives unequivocally acknowledging that free pricing for manufacturers allows the development of a competitive market environment, rendering price control measures for non-prescription medicines unnecessary. The realisation of the full potential of self-care will only be possible when European citizens are empowered and well informed about different products and their appropriate use. In the years to come, ensuring the right of all European citizens to self-care and have access to information and innovative, effective, safe and high quality products will remain a guiding principle for AESGP. As before, the association will pursue this objective highly committed, with responsibility and integrity. Hans Regenauer, AESGP President 4 aesgp.eu Message from the Director General AESGP has dedicated the past 50 years to advancing the practice of self- care in Europe. Throughout this time, the association strives to pursue its objectives by remaining faithful to the fundamental principles of professional competence and comprehensive service to members. In its work, AESGP relies on the close cooperation with European authorities and other stakeholders. It is critical that European bodies have a good understanding of the sectors specificities and a grasp on the actual impact of different decisions made on the self-care market. Close relationship with different stakeholder groups has been one of the most valuable and rewarding aspects of the associations work. Gaining a good understanding of the interests and concerns of others has allowed AESGP to reassess its own positioning on different issues and to work together with other stakeholders to achieve common goals. The same principle applies in our internal work with our members. The well organised network of associations and companies is the driving force of the association. It allows us to comprehensively assess the environment, reflect on developments and take informed political decisions. The close collaboration of the AESGP membership is the cornerstone of the associations success and where we can attribute the significant, tangible results for the entire consumer healthcare sector achieved through our political work on a national, European and global level. Hubertus Cranz, AESGP Director General 50 Years AESGP 5 History Establishment In 1963, a small group of representatives, primarily from the companies Miles, Nicholas and Vick, came together under the Chairmanship of Ben McClure of Vick International to discuss the possible need for collective action in light of the many threats and opportunities for the self-care industry, which was then referred to as the Proprietary Medicines Industry. A year later, on 3 February 1964, the Association Europenne des Spcialits Pharmaceutiques Grand Public, AESGP was founded in Paris. Vision At a time when self-care was considered to be either synonymous with home remedies or potentially unnecessary due to the expected advancements of the medical profession, the founders of the Association envisioned a strong self medication sector: A dynamic and innovative part of the pharmaceutical industry that would support increasingly empowered citizens to self- care. Restaurant bill from the inaugural meeting of the AESGP founders. 1961 1962 1963 1964 6 aesgp.eu 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 In the early years following its establishment, AESGP became the key liaison between the self-care industry and the European Community bodies. The growth of the sector in Europe was supported by AESGP, that was steadily developing in terms of membership and increased involvement in the European healthcare dialogue. Directive 65/65/EEC First European piece of legislation for pharmaceuticals. It provided the definition of a medicinal product, introduced the requirement for an authorisation prior to commercialisation and set out labeling provisions. By 1967 AESGP numbered 9 national member associations and represented more than 300 companies. Committee for Proprietary Medicinal Products set up to facilitate the principle of mutual recognition of marketing authorisations. Testing requirements introduced. AESGP, together with the Associations from the United States and Canada, was one of the founding members, in April 1970, of the World Federation of Proprietary Medicines Manufacturers (WFPMM) that would later on become WSMI. Reclassifications in Europe 1976: Antihistamines 50 Years AESGP 7 In the late 70s and early 80s the critical role individuals could and should play in maintaining their health was starting to be recognised and supported. WHO - Declaration of Alma-Ata () people have the right and duty to participate individually and collectively in the planning and implementation of their healthcare WHO, International Conference on Primary Health Care, Alma-Ata, April 1978 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 AESGP obtains the status of non- governmental organisation with the Council of Europe. AESGP Annual Meeting at the premises of the World Health Organisation in Copenhagen 1986 1981: Benzoyl peroxide 1983: Ibuprofen, Loperamide 1986: Hydrocortizone 1988: Nicotine 8 aesgp.eu 1991 1992 1993 1994 1995 The 90s were marked by significant developments and political divisions of the past giving their place to a united continent facing future with the promise of progress. Important changes were also observed in the European regulatory framework on pharmaceuticals, with a recognition of the role of non- prescription medicines. Reclassifications in Europe 1993: Aciclovir 1995: Fluconazole New legislation addressing: The classification status of medicinal products, distinguishing between prescription and non-prescription medicines Advertising, allowing the advertising of non-prescription medicines to the public Patient information (labelling and package leaflets) Wholesale distribution Homeopathic medicines AESGP implements a proactive policy for the development of a distinct non-prescription medicines sector in Eastern European countries. Related activities are supported by the publication of the policy document Developing Self-Medication in Central and Eastern Europe in Russian, Bulgarian, Czech, Hungarian, Polish and Ukrainian. The European Medicines Agency is established, and the centralised procedure for the authorisation and supervision of medicinal products comes into operation. 50 Years AESGP 9 1996 1997 1998 1999 2000 2001 AESGP and European doctors associations produce with the support of the European Commission the information document on What is self-medication (see more under Stakeholder collaboration, p.18). AESGP Food Supplements Committee established 2001/83/EC Consolidation of the European pharmaceutical legislation proposed. AESGP conducts study to improve patient information leaflets in order to make them more readable and useful to patients following request by the European Commission. AESGP conducts study on herbal medicines commissioned by the European Commission leading to the foundation of Directive 2004/24/EC. 1997: Ranitidine 1998: Domperidone 2000: Cimetidine 10 aesgp.eu 2002 2003 2004 2005 2006 2007 2008 Further EU enlargement and consequent harmonisation of rules for medicines in European countries has been a main recent development. Patient empowerment has also been a major trend in healthcare in the past years. 2001: Levonorgestol, Triamcilonone 2002: Loratadine 2003: Omeprazole G10 report The High Level Group on innovation and provision of medicines, a European Commission policy initiative, publishes report making significant policy recommendations for non- prescription medicines, noting that no price control is required for these products. Regulation 726/04, Title IV A revision of the European marketing authorisation procedures in 2004 gives non-prescription medicines the possibility to use the centralised procedure. Directive 2004/24/EC Legislation on herbal medicines, harmonising definition of traditional herbal medicinal products which could benefit from simplified procedure and setting up a Committee on Herbal Medicinal Products within the EMA. Development of information policy - European Commission funded AESGP study and presents indications for self- care (see page 21). European Union enlargement with ten new member states 50 Years AESGP 11 2009 2010 2011 2012 2013 2014 A policy initiative by AESGP identifies key areas requiring regulatory improvement in order to support the development of the self-care sector. Reclassifications through the centralised procedure 2009: Orlistat , Pantoprazole 2013: Esomeprazole Process on Corporate Responsibility The European Commission launches a 3-year policy initiative examining Ethics and Transparency in the pharmaceutical sector and Access to medicines in Europe and Africa. A dedicated multi-stakeholder project group on non-prescription medicines examines how to improve uptake of medicines following reclassification to non-prescription status. AESGP Medical Devices Committee established Addressing the growth of the self-care medical devices sector and the introduction of new European legislation on medical devices, AESGP sets up a new Committee on self-care medical devices. 2004: Simvastatin 2005: Chloramphenicol Agreement on elements of success Facilitating innovation Early stakeholder involvement Collaboration and engagement Training and education Access to information How to achieve good governance S e l f - c a r e : T h e f i r s t c h o i c e i n h e a l t h c a r e 7 avenue de Tervuren, 1040 Brussels, Belgium | Tel: + 32 2 735 51 30 | Fax: + 32 2 735 52 22 | info@aesgp.eu | www.aesgp.eu 12 aesgp.eu Mission The mission of AESGP is to ensure a sustainable positive development of the self-care industry. AESGP is working to achieve this by focusing on the following strategic objectives: To ensure that self-care plays an increasingly valuable role in healthcare as a positive and cost-effective contributor to the health and well-being of Europes citizens. To ensure that consumers can be well informed on the availability of self-care products, e.g. through advertising, presentation in pharmacies and through the development of brands which they can trust and rely on. To ensure recognition of the self-care industrys role as a reliable and trustworthy provider of self-care solutions. To achieve the adoption and implementation of a balanced and proportionate regulatory and economic framework that facilitates innovation and rapid market access for the widest range of self-care products in a consistent way across Europe. To promote a competitive environment for the self-care market, supporting free pricing by manufacturers for self-care products. Policy recommendations presented in the AESGP publication: Self-Care: A Winning Solution 50 Years AESGP 13 A balanced benefit-risk assessment for Marketing Authorisations Evaluation procedures for non-prescription medicines should take into consideration the benefits of the use of products in the practice of responsible self-care and not focus exclusively on risks regardless of whether or not these can be mitigated. A balanced assessment can better serve the interests of European citizens. Facilitating the switch process for appropriate ingredients A systematic, comprehensive approach to the reclassification of prescription medicines and active ingredients that takes into account the specific characteristics of self-care products and the need to reward investments is necessary to reduce the inequalities between European citizens in different member states and to take full advantage of the potential of self-care. Detailed product information Citizens should have access to detailed product information and instructions of use in order to be able to use self-care in a safe and responsible manner and thus improve their health. Comprehensive advertising Consumers should be able to get information through the communication channels they prefer without restrictions, be it in specialised written press, public displays, TV or digital media. Clear self- governing principles should be agreed in all EU member states. Better visibility Increased visibility of products at the point of sale should be assured to give consumers the time to make an informed and responsible choice concerning their self-care treatment. Consistent branding Consistent branding using traditional, wellknown brands should be encouraged in order to help individuals navigate through available products. Competitive pricing Industry should be allowed to engage in competitive pricing in order for the self- care market to function without distortions and for individuals to be able to reap all the benefits of a free market. Rigorous research on the role of self-care Stakeholders and institutions (e.g. the European Commission) involved in research should commission research on the role, importance and efficiency of self- care in Europes healthcare systems in order to define appropriate regulation and incentives. Challenge for the future - AESGP Policy Recommendations Policy recommendations presented in the AESGP publication: Self-Care: A Winning Solution 14 aesgp.eu AESGP Members AESGP is the voice of more than 2000 companies operating in the consumer healthcare sector in Europe, affiliated with AESGP directly or indirectly through the national associations. The AESGP constituency includes the main multinational companies as well as the European SMEs of the sector. Austria Denmark The Danish Association of the Pharmaceutical Industry Germany Ireland Netherlands ASSOSALUTE Associazione nazionale farmaci di automedicazione Belgium Czech Republic France Hungary Lithuania NEPROFARM Neprofarm NEPROFARM Belgium Croatia Finland Greece Italy National associations 50 Years AESGP 15 Portugal Sweden Poland Spain United-Kingdom Turkey GSK Boehringer Ingelheim Merz Merck PGT Pfizer Farbe/colour: PANTONE 288 CV Reckitt Benckiser Sanofi Norway Slovenia Switzerland Bayer Johnson-&-Johnson Novartis International companies (with a Board seat) 16 aesgp.eu How AESGP works AESGP brings the consumer healthcare industry into contact with policy makers and other stakeholders at the European level. Support on the national level is also provided when requested by national organisations. The Association is regularly consulted on healthcare issues and in particular pharmaceutical, food and health policy matters in Europe. AESGP comments and input in various consultations and policy initiatives provide a clear view of the self-care sectors positions to European Union institutions and contribute to the European health dialogue. The AESGP Board is composed of representatives of member associations and international companies and decides on the overall positioning of the association and important policy issues. Member associations Experts from member associations Commitees Board Member companies Experts from member companies 50 Years AESGP 17 AESGP Committees are the operational branches of the association. Based on the strategic guidance provided by the Board, AESGP Committees follow closely and in depth developments in their respective areas and implement policies of the association. The Committees also function as platforms for sharing information on national practices between AESGP members, with a view to studying and promoting best practices in the self-care sector in Europe. All work is coordinated by the AESGP offices in Brussels. Worldwide AESGP represents its members in the World Self-Medication Industry (WSMI). As a Non-Governmental Organisation (NGO) in official relations with the World Health Organization, WSMI contributes to WHOs Public Health goals through specialised expertise. WSMI also represents the industry in other international organisations, such as ICH, WIPO, Codex Alimentarius and internationl health professionals organisations. In close collaboration with WSMI, AESGP informs its members of all relevant developments taking place on a global level with a potential impact on Europe. Commitees Economic Affairs/PR Herbal medicines Regulatory Affairs Food Supplements Medical devices 18 aesgp.eu Stakeholder collaboration Over the past 50 years, AESGP has worked together with representative bodies of health professionals, patients and consumers in order to promote the practice of responsible self- care. AESGP worked together with the European umbrella organisation of medical doctors, the Standing Committee of European Doctors (CPME), and the European organisations of medical specialists (UEMS) and general practitioners (UEMO) to develop an information document on self-medication in an initiative supported by the European Commission. http://www.aesgp.eu/self-care Working with other industry associations AESGP also regularly works together with European umbrella associations representing other sections of (the pharmaceutical) industry to address jointly common issues faced in Europe. AESGP is member of numerous institutional stakeholder groups Health Policy Forum, eHealth Stakeholder Group, Process on Corporate Responsibility, Advisory Forum on the Food Chain and Animal and Plant Health , Working Groups on medical devices European Commission 50 Years AESGP 19 AESGP and PGEU, the representative body of community pharmacists in Europe, expressed their commitment to cooperate to promote the practice of selfcare in a Charter of Collaboration signed in 1993 and renewed in 2004 and 2012. The Charter acknowledges the key role of pharmacists in helping to ensure safe and effective use of non-prescription medicines. It also points to the role of the European self- medication industry in ensuring that innovative, safe products of high quality reach the European consumers. Key commitments by the two associations include developing pharmacies into health centres within their communities, improving citizens knowledge of health care products, and communicating the benefits of self- care to regulators AESGP also agreed with the European Association of Pharmaceutical Full-line Wholesalers (GIRP) to cooperate in the active presentation of non-prescription medicines in pharmacies and on the appropriate space/category management, taking into account and respecting national particularities and differences. Both organisations recognise the importance of supporting the training of pharmacists and their staff in their role to communicate the benefits of non-prescription medicines; on the exchange of information on the supply and purchase of non-prescription medicines in the marketplace; and the need to ensure the most efficient way to supply non-prescription medicines to pharmacies. 1993 2004 2012 EMA Interested Party EFSA Stakeholder Platform EUnetHTA Stakeholder Platform 20 aesgp.eu Publications E c o n o m i c a n d L e g a l F r a m e w o r k f o r N o n - P r e s c r i p t i o n M e d i c i n e s Economic and Legal Framework for Non-Prescription Medicines aesgp.eu Association Europenne des Spcialits Pharmaceutiques Grand Public Association of the European Self-Medication Industry Europischer Verband der Arzneimittel-Hersteller Self-care : The rst choice in health care 2013 Economic and Legal Framework for non- prescription medicines 2013 - 18th Edition (648 pages) Legal and Regulatory Framework for Herbal Medicines 2012 - 3rd Edition (354 pages) Legal and Regulatory Framework for Food Supplements 2012 - 2nd Edition (401 pages) The AESGP framework studies provide information on regulatory and market access provisions applicable to non-prescription medicines, herbal medicines and food supplements. Updated in collaboration mainly with WSMI and AESGP members, the studies are reference points for the sector and are often cited in various activities and publications by health authorities and other stakeholders. 1993 Self-Medication and the Pharmacist 1993 Developing Self-Medication in Central and Eastern Europe 1994 The Individual and Health Care: Added Value through Self-Medication 1996 The Value of the same Trademark for medicines with a different Legal Status 1997 CPME/AESGP Brochure on Self- Medication, supported by the European Commission 1997 The Visibility of Self-Medication Products in the Changing Pharmacy Environment 1998 Study on herbal medicinal products carried out by AESGP on behalf of the European Commission in English/German 1998 Medicines for Europe - A practical guide for the development, registration and marketing of medicinal products in the European Union 1998 Encouraging self-medication can reduce the healthcare cost burden: An Economic Analysis 1998 Improving Visibility of Self-Medication in Pharmacies 1999 Deregulation 2001-The Future of Medicine Regulation in Europe
2002 Common statement and Report of the PGEU-AESGP Workshop How appropriate presentation of non- prescription medicines enhances the role of the pharmacist 2002 Final report of the AESGP research project Development of an information policy for medicinal products 2004 The Economic and Public Health value of Self-medication 2008 Smart Regulation 2015 2012 Self-Care: A Winning Solution Annual reports highlighting AESGP activities and conference repots presenting meeting proceedings http://www.aesgp.eu/publications 50 Years AESGP 21 Acne Allergic conjunctivitis Cold Cold sores Constipation Cough Diarrhoea Emergency contraception Erectile dysfunction Fever Flu prevention Flu treatment Haemorrhoids Hayfever prevention Arthritic pain Caries prevention Cholesterol lowering/lipid control Dermatitis/eczema Hayfever treatment Male pattern baldness Neural tube defect prevention Bacterial conjunctivitis Cystitis Exercise-induced angina Helminth infections Lower urinary tract infection Vaginal thrush Anxiety Asthma Benign prostatic hypertrophy Chronic insomnia Depression (mild to moderate) Diabetes (prevention of complications and treatment with oral agents) Heart disease prevention Herpes genitalis Irritable bowel syndrome Inflammatory bowel disease Gout Hypertension Incontinence Headache Indigestion/heartburn Insomnia (temporary) Mild/moderate pain Minor cuts and bruises Mouth ulcers Nausia from known causes Smoking cessation Sore throat Symptoms of PMS Topical bacterial infections Weight management Self-diagnosis & self-management Recurrent/semi- chronic condition Short-term use/ acute condition Long term use/ chronic condition Doctor consultation & other health professional advice & patient self-management (with/without medical advice) Indications for self-care. From the European Commission funded project conducted by AESGP: Information policy for non-prescription medicines (2002). The project examined different indications for self-care and presented the concept of collaborative care. Malaria prevention Menopause syndrome Migraine Obesity Oral contraception Osteoporosis prophylaxis Psoriasis (mild) Rheumatism Venous leg ulcers 22 aesgp.eu The significant economic value of self-medication was examined in different AESGP publications. In 2004, an economic analysis identified the significant savings potential of self-medication by estimating the cost reductions of switching treatment from professional care to self- medication. The publication Self-Care: A Winning Solution also addressed the public health and economic benefits of self-care, providing an overview of the outcomes of economic analyses at national level. Each year, AESGP publishes online an overview of sales figures in Europe. The market data are provided mostly by national member associations and collected in the context of the preparation of the Economic and Legal Framework study for non prescription medicines. http://www.aesgp.eu/facts-figures/market-data (open access) Market data 50 Years AESGP 23 Ingredients An online database of ingredients with non-prescription status in European and non-European countries is maintained by AESGP. The database allows users to search ingredients by name in order to find their classification status in one or all available countries, while a search by parameter function allows users to get information on the classification status based of ingredients based on ATC levels 1 or 2, the year of switch, or by country. Information in the database comes mainly from WSMI and AESGP member Ingredients Directory 2014 http://www.aesgp.eu/facts-figures/market-data (open access) Data Bank data.aesgp.eu AESGP Data Bank The AESGP Data Bank is the online database launched in June 2014. It includes information previously found in the AESGP studies Economic and Legal Framework for non-prescription medicines and Legal and Regulatory Framework for Herbal Medicines. Providing a variety of options to users and flexibility in the presentation of results, a key objective of the new database is to improve further the understanding of circumstances under which the practice of responsible self-care can be further encouraged and supported. http://data.aesgp.eu (for registered users only) http://www.aesgp.eu/facts-figures/data-bank (registration information, open access) associations and is updated regularly by AESGP. The outcomes of the March 2014 update are also presented in the publication AESGP Ingredients Directory. 24 aesgp.eu Dublin April 2628, 1978 June 57, 2002 Paris November 1963 (foundation) March 1965 December 2, 1966 June 1315, 1984 Annual Meetings Brussels October 30, 1967 October 3031, 1972 June 2729, 1990 Rome November 2122, 1969 June 710, 1989 (together with the 9th General Assembly of WFPMM) June 810, 2011 June 69, 2001 London Nov. 28 Dec. 1, 1971 (together with the 1st WFPMM General Assembly) February 2527, 1976 June 1416, 1994 June 35, 2014 (together with the 18th WSMI General Assembly of WSMI) Madrid May 24, 1979 June 24, 2004 Amsterdam April 2325, 1980 June 911, 1993 Funchal (Madeira) May 2023, 1981 Cannes October 2830, 1973 June 24, 1991 June 46, 2003 Barcelona June 2426, 1992 Lisbon June 710, 1995 June 57, 2013 Nice June 68, 2012 50 Years AESGP 25 Lausanne October 2425, 1968 Rome November 2122, 1969 June 710, 1989 (together with the 9th General Assembly of WFPMM) June 810, 2011 June 69, 2001 Baden-Baden October 1114, 1970 Vienna October 34, 1974 May 2022, 1987 June 35, 2009 Geneva March 2023, 1977 (together with the 4th WFPMM General Assembly) June 1517, 1988 June 13, 2005 (together with the 15th WSMI General Assembly) Amsterdam April 2325, 1980 June 911, 1993 Athens May 1214, 1982 May 2023, 1998 June 79, 2006 Stockholm June 810, 1983 June 1113, 2008 Munich May 2931, 1985 Copenhagen June 1113, 1986 Istanbul May 29June 1, 1996 Budapest June 1821, 1997 Berlin June 912, 1999 (together with the 13th WSMI General Assembly) Helsinki May 1720, 2000 Warsaw 43. June 46, 2007 Dubrovnik June 912, 2010 Munich May 29-31, 1985 26 aesgp.eu Jean Sall | France Daniel Callewaert | Belgium Hans W. Bach | Germany Frederick G. Razzell | UK Pierre Teisseire | France D.N.A. McLure | UK P. Giorgio Aquino | Italy Anthony J. Jamison | UK Antony B. Claasen | Netherlands Jos-Antonio Perez-Espana | Spain John R. Markley | UK Heinz Schmidgall | Switzerland Roberto Montanari | Italy Berndt van Till | Netherlands Hugues Lanrezac | France Gerhard Stummerer | Austria Alessandro Banchi | Italy Albert Esteve | Spain Hans van Zoonen | Switzerland Hans Regenauer | Germany Presidents and Directors General Presidents 1 9631 969 1 9691 972 1 9721 974 1 9741 975 1 9751 978 1 9781 980 1 9801 981 1 981 1 984 1 9841 986 1 9861 988 1 9881 989 1 9891 992 1 9921 994 1 9941 996 1 9961 998 19982000 20002002 20022005 20052009 Since 2009 1 9641 968 1 9681 978 1 9791 988 Since 1988 Directors General Beverley Landrey Pierre A. Visseur Werner Sedlag Hubertus Cranz Logo 1964 - 1989 Logo 1989 - 1999 Logo 1999 - 2005 Logo introduced in 2005 50 Years AESGP 27 Directors General AESGP Euro OTC News Each month, AESGP publishes the AESGP Euro OTC News. The newsletter is distributed to the AESGP constituency with the purpose of informing members about the latest developments on non-prescription medicines, food supplements and self-care medical devices. The newsletter provides an overview of issues circulated in the course of the month before to Committee members. It also provides all the latest information on AESGP activities as well as news from members. AESGP launched the first issue of its newsletter in 1990. Today, after more than 250 issues circulated in paper and electronic version, the AESGP Euro OTC News continues to serve as an informative and useful communication tool and is part of the AESGP service to its members. Self Care: The rst choice in healthcare The Association of the European Self-Medication Industry is the representative body of the manufacturers of non-prescription medicines, food supplements and self-care medical devices in Europe. AESGP 7 avenue de Tervuren B-1040 Brussels, Belgium Tel: +32 2 735 51 30 Fax: +32 2 735 52 22 E-mail: info@aesgp.eu aesgp.eu