1. This document provides an overview of the anatomy and physiology of the heart. It describes the internal and external structures of the heart, as well as the pathways of blood flow through the heart and cardiac cycle.
2. Key details include a description of the four chambers, valves, vessels, and electrical conduction system of the heart. The roles of the sympathetic and parasympathetic nervous systems in regulating heart rate are also summarized.
3. Physiological concepts such as cardiac output, stroke volume, preload, afterload and contractility are defined in relation to their influence on heart function.
Original Description:
Human Anatomy & Physiology (8th Edition) by Elaine Marieb, ISBN 978-0321694157
1. This document provides an overview of the anatomy and physiology of the heart. It describes the internal and external structures of the heart, as well as the pathways of blood flow through the heart and cardiac cycle.
2. Key details include a description of the four chambers, valves, vessels, and electrical conduction system of the heart. The roles of the sympathetic and parasympathetic nervous systems in regulating heart rate are also summarized.
3. Physiological concepts such as cardiac output, stroke volume, preload, afterload and contractility are defined in relation to their influence on heart function.
1. This document provides an overview of the anatomy and physiology of the heart. It describes the internal and external structures of the heart, as well as the pathways of blood flow through the heart and cardiac cycle.
2. Key details include a description of the four chambers, valves, vessels, and electrical conduction system of the heart. The roles of the sympathetic and parasympathetic nervous systems in regulating heart rate are also summarized.
3. Physiological concepts such as cardiac output, stroke volume, preload, afterload and contractility are defined in relation to their influence on heart function.
!6789:; )* < %6: !7;=>?@7ABCD7; 0EA9:F5 %6: ":7;9 ":7;9 #G79?FE ApproxlmaLely Lhe slze of your flsL LocaLlon Superlor surface of dlaphragm LefL of Lhe mldllne AnLerlor Lo Lhe verLebral column, posLerlor Lo Lhe sLernum ":7;9 !?@:;>GH erlcardlal physlology roLecLs and anchors hearL revenLs overfllllng ":7;9 !?@:;>GH erlcardlal anaLomy llbrous perlcardlum Serous perlcardlum (separaLed by perlcardlal cavlLy) Lplcardlum (vlsceral layer) ":7;9 I7DD Lplcardlum - vlsceral layer of Lhe serous perlcardlum Myocardlum - cardlac muscle layer formlng Lhe bulk of Lhe hearL llbrous skeleLon of Lhe hearL - crlsscrosslng, lnLerlaclng layer of connecLlve Llssue Lndocardlum - endoLhellal layer of Lhe lnner myocardlal surface &J9:;G7D ":7;95 47K?; /:AA:DA ?L 96: ":7;9 M#G9:;>?; />:NO 8eLurnlng blood Lo Lhe hearL Superlor and lnferlor venae cavae 8lghL and lefL pulmonary velns Conveylng blood away from Lhe hearL ulmonary Lrunk, whlch spllLs lnLo rlghL and lefL pulmonary arLerles Ascendlng aorLa (Lhree branches) - brachlocephallc, lefL common caroLld, and subclavlan arLerles &J9:;G7D ":7;95 /:AA:DA 9679 0C88DEP,;7>G 96: ":7;9 M#G9:;>?; />:NO ArLerles - rlghL and lefL coronary (ln aLrlovenLrlcular groove), marglnal, clrcumflex, and anLerlor lnLervenLrlcular velns - small cardlac veln, anLerlor cardlac veln, and greaL cardlac veln &J9:;G7D ":7;95 47K?; /:AA:DA ?L 96: ":7;9 M$?A9:;>?; />:NO 8eLurnlng blood Lo Lhe hearL 8lghL and lefL pulmonary velns Superlor and lnferlor venae cavae Conveylng blood away from Lhe hearL AorLa 8lghL and lefL pulmonary arLerles Q !"#$%&' )* + !#',-./#0!12#' 030%&45 %"& "&#'%
&J9:;G7D ":7;95 /:AA:DA 9679 0C88DEP,;7>G 96: ":7;9 M$?A9:;>?; />:NO ArLerles - rlghL coronary arLery (ln aLrlovenLrlcular groove) and Lhe posLerlor lnLervenLrlcular arLery (ln lnLervenLrlcular groove) velns - greaL cardlac veln, posLerlor veln Lo lefL venLrlcle, coronary slnus, and mlddle cardlac veln R;?AA #G79?FE ?L ":7;95 S;?G97D 0:B9>?G lronLal secLlon showlng lnLerlor chambers and valves Ma[or vessels leadlng Lo and from Lhe hearL #9;>7 ?L 96: ":7;9 ALrla are Lhe recelvlng chambers of Lhe hearL Lach aLrlum has a proLrudlng aurlcle ecLlnaLe muscles mark aLrlal walls 8lood enLers rlghL aLrla from superlor and lnferlor venae cavae and coronary slnus 8lood enLers lefL aLrla from pulmonary velns /:G9;>BD:A ?L 96: ":7;9 venLrlcles are Lhe dlscharglng chambers of Lhe hearL aplllary muscles and Lrabeculae carneae muscles mark venLrlcular walls 8lghL venLrlcle pumps blood lnLo Lhe pulmonary Lrunk LefL venLrlcle pumps blood lnLo Lhe aorLa $796N7E ?L TD??= 96;?CH6 96: ":7;9 7G= 2CGHA 8lghL aLrlum ! Lrlcuspld valve ! rlghL venLrlcle 8lghL venLrlcle ! pulmonary semllunar valve ! pulmonary arLerles ! lungs Lungs ! pulmonary velns ! lefL aLrlum LefL aLrlum ! blcuspld valve ! lefL venLrlcle LefL venLrlcle ! aorLlc semllunar valve ! aorLa AorLa ! sysLemlc clrculaLlon !?;?G7;E !>;BCD79>?G Coronary clrculaLlon ls Lhe funcLlonal blood supply Lo Lhe hearL CollaLeral rouLes lnsure blood dellvery Lo hearL even lf ma[or vessels are occluded ":7;9 /7D@:A PearL valves lnsure unldlrecLlonal blood flow Lhrough Lhe hearL ALrlovenLrlcular (Av) valves lle beLween Lhe aLrla and Lhe venLrlcles Av valves prevenL backflow lnLo Lhe aLrla when venLrlcles conLracL Chordae Lendlneae anchor Av valves Lo paplllary muscles AorLlc semllunar valve lles beLween Lhe lefL venLrlcle and Lhe aorLa ulmonary semllunar valve lles beLween Lhe rlghL venLrlcle and pulmonary Lrunk Semllunar valves prevenL backflow of blood lnLo Lhe venLrlcles 4>B;?AB?8>B ":7;9 4CABD: #G79?FE Cardlac muscle ls sLrlaLed, shorL, faL, branched, and lnLerconnecLed ConnecLlve Llssue endomyslum acLs as boLh Lendon and lnserLlon lnLercalaLed dlscs anchor cardlac cells LogeLher and allow free passage of lons PearL muscle behaves as a funcLlonal syncyLlum !"#$%&' )* + !#',-./#0!12#' 030%&45 %"& "&#'% U
!7;=>7B 4CABD: !?G9;7B9>?G PearL muscle: ls sLlmulaLed by nerves and self-exclLable (auLomaLlclLy) ConLracLs as a unlL Pas a long (230 ms) absoluLe refracLory perlod Cardlac muscle conLracLlon ls slmllar Lo skeleLal muscle conLracLlon ":7;9 $6EA>?D?HE5 -G9;>GA>B !?G=CB9>?G 0EA9:F AuLorhyLhmlc cells: lnlLlaLe acLlon poLenLlals Pave unsLable resLlng poLenLlals called !"#$%"&$' !)*$+*,"-. use calclum lnflux (raLher Lhan sodlum) for rlslng phase of Lhe acLlon poLenLlal ":7;9 $6EA>?D?HE5 0:VC:GB: ?L &JB>979>?G SlnoaLrlal (SA) node generaLes lmpulses abouL 73 Llmes/mlnuLe ALrlovenLrlcular (Av) node delays Lhe lmpulse approxlmaLely 0.1 second lmpulse passes from aLrla Lo venLrlcles vla Lhe aLrlovenLrlcular bundle (bundle of Pls) Av bundle spllLs lnLo Lwo paLhways ln Lhe lnLervenLrlcular sepLum (bundle branches) 8undle branches carry Lhe lmpulse Loward Lhe apex of Lhe hearL urkln[e flbers carry Lhe lmpulse Lo Lhe hearL apex and venLrlcular walls &J9;>GA>B -GG:;@79>?G ?L 96: ":7;9 PearL ls sLlmulaLed by Lhe sympaLheLlc cardloacceleraLory cenLer PearL ls lnhlblLed by Lhe parasympaLheLlc cardlolnhlblLory cenLer &D:B9;?B7;=>?H;786E LlecLrlcal acLlvlLy ls recorded by elecLrocardlogram (LCC) wave corresponds Lo depolarlzaLlon of SA node C8S complex corresponds Lo venLrlcular depolarlzaLlon 1 wave corresponds Lo venLrlcular repolarlzaLlon ALrlal repolarlzaLlon record ls masked by Lhe larger C8S complex !7;=>7B !EBD: Cardlac cycle refers Lo all evenLs assoclaLed wlLh blood flow Lhrough Lhe hearL SysLole - conLracLlon of hearL muscle ulasLole - relaxaLlon of hearL muscle $67A:A ?L 96: !7;=>7B !EBD: venLrlcular fllllng - mld-Lo-laLe dlasLole PearL blood pressure ls low as blood enLers aLrla and flows lnLo venLrlcles Av valves are open Lhen aLrlal sysLole occurs venLrlcular sysLole ALrla relax 8lslng venLrlcular pressure resulLs ln closlng of Av valves lsovolumeLrlc conLracLlon phase venLrlcular e[ecLlon phase opens semllunar valves lsovolumeLrlc relaxaLlon - early dlasLole venLrlcles relax 8ackflow of blood ln aorLa and pulmonary Lrunk closes semllunar valves ulcroLlc noLch - brlef rlse ln aorLlc pressure caused by backflow of blood reboundlng off semllunar valves W !"#$%&' )* + !#',-./#0!12#' 030%&45 %"& "&#'%
":7;9 0?CG=A PearL sounds (lub-dup) are assoclaLed wlLh closlng of hearL valves !7;=>7B .C98C9 M!.O 7G= ':A:;@: CC ls Lhe amounL of blood pumped by each venLrlcle ln one mlnuLe CC ls Lhe producL of hearL raLe (P8) and sLroke volume (Sv) P8 ls Lhe number of hearL beaLs per mlnuLe Sv ls Lhe amounL of blood pumped ouL by a venLrlcle wlLh each beaL Cardlac reserve ls Lhe dlfference beLween resLlng and maxlmal CC !7;=>7B .C98C95 &J7F8D: CC (ml/mln) = P8 (73 beaLs/mln) x Sv (70 ml/beaL) CC = 3230 ml/mln (3.23 L/mln) ':HCD79>?G ?L 09;?X: /?DCF: Sv = end dlasLollc volume (Luv) mlnus end sysLollc volume (LSv) Luv = amounL of blood collecLed ln a venLrlcle durlng dlasLole LSv = amounL of blood remalnlng ln a venLrlcle afLer conLracLlon S7B9?;A #LL:B9>GH 09;?X: /?DCF: reload - amounL venLrlcles are sLreLched by conLalned blood ConLracLlllLy - cardlac cell conLracLlle force due Lo facLors oLher Lhan Luv AfLerload - back pressure exerLed by blood ln Lhe large arLerles leavlng Lhe hearL S;7GX+097;D>GH 27N ?L 96: ":7;9 reload, or degree of sLreLch, of cardlac muscle cells /$0)'$ Lhey conLracL ls Lhe crlLlcal facLor conLrolllng sLroke volume Slow hearLbeaL and exerclse lncrease venous reLurn Lo Lhe hearL, lncreaslng Sv 8lood loss and exLremely rapld hearLbeaL decrease Sv $;:D?7= 7G= #L9:;D?7= &J9;>GA>B S7B9?;A -GLDC:GB>GH 09;?X: /?DCF: ConLracLlllLy ls Lhe lncrease ln conLracLlle sLrengLh, lndependenL of sLreLch and Luv lncrease ln conLracLlllLy comes from: lncreased sympaLheLlc sLlmull CerLaln hormones Ca 2+ and some drugs AgenLs/facLors LhaL decrease conLracLlllLy lnclude: Acldosls lncreased exLracellular poLasslum Calclum channel blockers !?G9;7B9>D>9E 7G= Y?;:8>G:86;>G: SympaLheLlc sLlmulaLlon releases noreplnephrlne and lnlLlaLes a cycllc AM second-messenger sysLem !"#$%&' )* + !#',-./#0!12#' 030%&45 %"& "&#'% Z
':HCD79>?G ?L ":7;9 '79:5 #C9?G?F>B Y:;@?CA 0EA9:F SympaLheLlc nervous sysLem (SnS) sLlmulaLlon ls acLlvaLed by sLress, anxleLy, exclLemenL, or exerclse arasympaLheLlc nervous sysLem (nS) sLlmulaLlon ls medlaLed by aceLylchollne and opposes Lhe SnS nS domlnaLes Lhe auLonomlc sLlmulaLlon, slowlng hearL raLe and causlng vagal Lone T7>G[;>=H: ':LD:J 8alnbrldge (aLrlal) reflex - a sympaLheLlc reflex lnlLlaLed by lncreased blood ln Lhe aLrla Causes sLlmulaLlon of Lhe SA node SLlmulaLes barorecepLors ln Lhe aLrla, causlng lncreased SnS sLlmulaLlon !6:F>B7D ':HCD79>?G ?L 96: ":7;9 1he hormones eplnephrlne and Lhyroxlne lncrease hearL raLe lnLra- and exLracellular lon concenLraLlons musL be malnLalned for normal hearL funcLlon S7B9?;A -G@?D@:= >G ':HCD79>?G ?L !7;=>7B .C98C9 "?F:?A979>B -F[7D7GB:A Pypocalcemla - reduced lonlc calclum depresses Lhe hearL Pypercalcemla - dramaLlcally lncreases hearL lrrlLablllLy and leads Lo spasLlc conLracLlons PypernaLremla - blocks hearL conLracLlon by lnhlblLlng lonlc calclum LransporL Pyperkalemla - leads Lo hearL block and cardlac arresL 1achycardla - hearL raLe over 100 beaLs/mln 8radycardla - hearL raLe less Lhan 60 beaLs/mln !?GH:A9>@: ":7;9 S7>DC;: M!"SO CongesLlve hearL fallure (CPl), caused by: Coronary aLherosclerosls lncreased blood pressure ln aorLa Successlve myocardlal lnfarcLs ullaLed cardlomyopaLhy (uCM) ,:@:D?8F:G97D #A8:B9A ?L 96: ":7;9 Lmbryonlc hearL chambers Slnus venous ALrlum venLrlcle 8ulbus cordls leLal hearL sLrucLures LhaL bypass pulmonary clrculaLlon loramen ovale connecLs Lhe Lwo aLrla uucLus arLerlosus connecLs pulmonary Lrunk and Lhe aorLa #H:+':D79:= !67GH:A #LL:B9>GH 96: ":7;9 Sclerosls and Lhlckenlng of valve flaps uecllne ln cardlac reserve llbrosls of cardlac muscle ALherosclerosls