1. Iodide trapping- Diet (GIT) 4. Organification - Thyroglobulin + Iodine 2. Formation of Thyroglobulin 5. Coupling - Mono + Di compounds 3. Peroxidation - Iodide iodine 6. T4 and T3 formation Wolff-Chaikoff Effect Increasing doses of I - increase hormone synthesis initially Higher doses cause cessation of hormone formation. This effect is countered by the Iodide leak from normal thyroid tissue. Patients with autoimmune thyroiditis may fail to adapt and become hypothyroid. Jod-Basedow Effect Opposite of the Wolff-Chaikoff effect Excessive iodine loads induce hyperthyroidism Observed in hyperthyroid disease processes Graves disease Toxic multinodular goiter Toxic adenoma This effect may lead to symptomatic thyrotoxicosis in patients who receive large iodine doses from Dietary changes Contrast administration Iodine containing medication (Amiodarone) TRH Produced by Hypothalamus Release is pulsatile, circadian Downregulated by T 3
Travels through portal venous system to adenohypophysis Stimulates TSH formation Produced by Adenohypophysis Thyrotrophs Upregulated by TRH Downregulated by T 4 , T 3
Travels through portal venous system to cavernous sinus, body. Stimulates several processes Iodine uptake Colloid endocytosis Growth of thyroid gland Thyroid Hormone Majority of circulating hormone is T 4
98.5% T 4
1.5% T 3
Total Hormone load is influenced by serum binding proteins Albumin 15% Thyroid Binding Globulin 70% Transthyretin 10% Regulation is based on the free component of thyroid hormone Function of Thyroid Hormone Increases BMR Increase heat production Basically increased metabolism
Disorders of the Thyroid Gland HYPOsecretion: HYPOTHYROIDISM A hypothyroid state characterized by decreased secretions of T3 and T4 CAUSES: Hypofunctioning tumor, Pituitary tumor, Ablation therapy, Surgical removal of thyroid Pathophysiology: Decreased T 3 and T 4 Decreased basal metabolism Two Forms 1. Endemic- Diet 2. Sporadic- goiterogenous foods ASSESSMENT findings for Hypothyroidism 1. Lethargy and fatigue 7. Dry hair and skin, loss of body hair 2. Weakness and paresthesia 8. Generalized puffiness and edema around the eyes and face 3. COLD intolerance 9. Forgetfulness and memory loss 4. Weight gain 10. Slowness of movement 5. Bradycardia 11. Menstrual irregularities and cardiac irregularities 6. Constipation NURSING INTERVENTIONS 1. Monitor VS especially HR 2. Administer hormone replacement: usually Levothyroxine( Synthroid) - should be taken on an empty stomach 3. Instruct patient to eat LOW calorie, LOW cholesterol and LOW fat diet 4. Manage constipation appropriately 5. Provide a WARM environment 6. Avoid sedatives and narcotics because of increased sensitivity to these medications 7. Instruct patient to report chest pain promptly Complication Myxedema Coma a drastic decrease in metabolic rate, hypoventilation leading to metabolic acidosis, hypothermia and hypotension - coma - medical emergency Tx: TH replacement, levothyroxine Na HYPERfunctioning: HYPERTHYROIDISM Called GRAVES DISEASE A hyperthyroid state characterized by increased circulating T3 and T4 CAUSES: Auto-immune disorder, toxic goiter and tumor Pathophysiology: Increased hormone activity Increased basal metabolism ASSESSMENT Findings for Hyperthyroidism 1. Weight loss 7. Warm skin 2. HEAT intolerance 8. Diaphoresis 3. Hypertension 9. Smooth and soft skin 4. Tachycardia and palpitations 10. Oligomenorrhea to amenorrhea 5. Exopthalmos 11. Fine tremors and nervousness 6. Diarrhea 12. Irritability, mood swings, personality changes and agitation NURSING INTERVENTIONS 1. Provide adequate rest periods in a quiet room 2. Administer anti-thyroid medications that block hormone synthesis - Methimazole and PTU 3. Provide a HIGH-calorie diet, HIGH protein 4. Manage diarrhea 5. Provide a cool and quiet environment 6. Avoid giving stimulants 7. Provide eye care - Hypoallergenic tape for eyelid closure 8. Administer PROPRANOLOL for tachycardia 9. Administer IODINE preparation - Lugols solution and SSKI to inhibit the release of T3 and T4 10. Prepare clients for radioactive iodine therapy 11. Prepare patient for thyroidectomy 12. Manage thyroid storm appropriately Complication Thyroid Storm An acute LIFE-threatening condition characterized by excessive thyroid hormones in the body Characterized by high fever, tachycardia, delirium, dehydration and extreme irritability. CAUSE: Manipulation of the thyroid during surgery causing the release of excessive hormones in the blood ASSESSMENT Findings for Thyroid Storm 1. HIGH fever 4. Delirium, personality changes 2. Tachycardia and Tachypnea 5. Severe vomiting and diarrhea 3. Systolic HYPERtension 6. Restlessness, Agitation, confusion and Seizures NURSING INTERVENTIONS 1. Maintain PATENT airway and adequate ventilation 2. Administer anti-thyroid medications such as Lugols solution, Propranolol, and Glucocorticoids 3. Monitor VS 4. Monitor Cardiac rhythms 5. Administer PARACETAMOL (not Aspirin) for FEVER 6. Manage Seizures as required. 7. Provide a quiet environment THYROIDECTOMY Removal of the thyroid gland PRE-OPERATIVE CARE - Thyroidectomy 1. Obtain VS and weight 2. Assess for Electrolyte levels, glucose levels and T 3 /T 4 levels 3. Provide pre-operative teaching like coughing and deep breathing, early ambulation and support of the neck when moving 4. Administer prescribed medications- Lugols to decrease size, KISS, NaI 5. Assess for signs of hypocalcemia (+) Trosseaus and (+) Chvosteks signs Major Complications 1. Bleeding 3. Hypocalcemia 2. Laryngeal nerve damage 4. Thyroid storm POST-OPERATIVE CARE - Thyroidectomy 1. Position patient: Semi-Fowlers, neck on neutral position 2. Monitor for respiratory distress - apparatus at bedside: tracheostomy set, O2 tank, and suction machine 3. Check for edema and bleeding by noting the dressing anteriorly and at the back of the neck 4. Limit client talking 5. Assess for HOARSENESS Expected to be present only initially, limit excess vocalization If persistent, may indicate damage to laryngeal nerve 6. Monitor for Laryngeal Nerve damage Respiratory distress, Dysphonia, voice changes, Dysphagia and restlessness 7. Monitor for signs of HYPOCALCEMIA and tetany due to trauma of the parathyroid 8. Prepare Calcium gluconate 9. Monitor for thyroid storm Disorders of the Parathyroid Gland Hypo-functioning: HYPOPARATHYROIDISM Hypo-secretion of parathyroid hormone CAUSES: tumor, removal of the gland during thyroid surgery Pathophysiology: Decreased PTH Deranged calcium metabolism ASSESSMENT Findings for Hypoparathyroidism 1. Signs of HYPOCALCEMIA 5. Bronchospasms, laryngospasms, and dysphagia 2. Numbness and tingling sensation on the face 6. Cardiac dysrhythmias 3. Muscle cramps 7. Hypotension 4. (+) Trosseaus and (+) Chvosteks signs 8. Anxiety, irritability and depression NURSING INTERVENTIONS 1. Monitor VS and signs of HYPOcalcemia 2. Initiate seizure precautions and management 3. Place a tracheostomy set, O2 tank, and suction at the bedside 4. Prepare CALCIUM gluconate 5. Provide a HIGH-calcium and LOW phosphate diet 6. Advise client to eat Vitamin D rich foods 7. Administer Phosphate binding drugs Hyper-functioning: HYPERPARATHYROIDISM Hyper-secretion of the gland CAUSE: Tumor Pathophysiology: Increased PTH Increased CALCIUM levels in the body ASSESSMENT Findings for Hyperparathyroidism 1. Fatigue and muscle weakness/pain 5. Constipation 2. Skeletal pain and tenderness 6. Hypertension 3. Fractures 7. Cardiac Dysrhythmias 4. Anorexia/N/V epigastric pain 8. Renal Stones NURSING INTERVENTIONS 1. Monitor VS, Cardiac rhythm, I and O 2. Monitor for signs of renal stones, skeletal fractures. Strain all urine. 3. Provide adequate fluids- force fluids 4. Administer prescribed Furosemide to lower calcium levels 5. Administer NORMAL saline 6. Administer calcium chelators 7. Administer CALCITONIN 8. Prepare the patient for surgery