Features:

Made from Wax Corn Starch

MW 130 KD / DS 0.4
exhibits 100% volume effect
Volume duration of 4-6 hours

Indications:
Therapy and prophylaxis of
hypovolemia and shock
associated with surgery, trauma,
sepsis and burns

Dosage:
Up to 50 ml/kg/BW/day

Availability:
500 ml Freeflex Bags in isotonic
saline solution

Features:
Made from Wax Corn Starch
MW 130 KD / DS 0.4
exhibits 100% volume effect
Volume duration of 4-6 hours

Indications:
Therapy and prophylaxis of
hypovolemia and shock
associated with surgery, trauma,
sepsis and burns

Dosage:
Up to 50 ml/kg/BW/day

Availability:
500 ml Freeflex Bags in an
isotonic electrolyte solution

6% HES
130/0. 4/9: 1
Molecular Weight Degree of Substitution Substitution Pattern
6% Voluven / Volulyte
130/0. 4/9: 1
Molecular Weight Degree of Substitution Substitution Pattern
Reduced proportion of
large, highly substituted
molecules that may
cause coagulation
disorders.
Results in the maintenance
of adequate volume effect &
improvement of safety profile

Known as C2:C6 ratio
Provides good duration of
volume effect
Waxy Maize
Potato Starch
VERSUS
95% amylopectin, 5% amylose

rapidly broken down in the body and
so could have a longer-lasting volume
effect vs. potato-based starch (e.g.
Tetraspan)

Low phosphate-ester groups doesnt
interfere with blood clotting
mechanism, kidney and liver function

70-80% amylopectin

20-30% amylose




High load of phosphate-ester groups
may interfere with blood clotting
mechanism, kidney and liver function

S t r u c t u r a l D i f f e r e n c e s a n d
P o s s i b l e C o n s e q u e n c e s
PLASMA VOLUME EXPANSION EFFECTS
0
20
40
60
80
100
120
140
160
0.5 1 2 3 4 5 6 7 8 9
Hours after
Infusion
Blood Volume
(% Infusion)
Voluven 6% 130/0.4 Crystalloids Gelatins

Voluven / Volulyte 6%

130 / 0.4
provides 100% volume effect for up
to 4-6 hours
Crystalloids 40%, up to 45 minutes.
Gelatins 70%, up to 2 hours.
AND VOLUME SUBSTITUTION RATIO
3 bags; 1 bag
1;1
4.7 bags ; 1 bag
PLASMA VOLUME EXPANSI ON EFFECTS
AND VOL UME SUBST I T UT I ON RAT I O

LESS RISK OF
ANAPHYLACTOID
REACTIONS

compared with gelatin and
dextran
similar to body glycogen
NO RELEVANT PLASMA
ACCUMULATION

can be safely given to patients
repeatedly for several days
without relevant plasma
accumulation


NO CLINICALLY RELEVANT
INFLUENCE ON RENAL
FUNCTION

Voluven is safe in patients
with all range of renal
impairment as long as urine
flow is preserved

Vol uv e n

&
Vo l u l y t e

In summary, with Voluven

and Volulyte

we achieve a balance between:
JLGVTR01202011
Voluven

& Volulyte

dont accept imitations