US 20130310428Al

( 12) Patent Application Publication ( 10) Pub. N o. : US 2013/0310428 A1

( 19 ) United States
J os eph et al. ( 43) Pub. D ate: N OV. 21, 2013
( 5 4) THERMO-STABLE, ARSEN IC-FREE Publication Clas s i? cation
SYN ERGISTIC BIOCID E CON CEN TRATE
COMPOSITION FOR POLYMER MATRICES ( 5 1) Int- Cl
AN D PROCESS FOR PREPARIN G SAME A01N 43/38 ( 2006 -01)
A01N 43/7 8 ( 2006 . 01)
( 7 5 ) Inv entor s : Bar tk o J os eph , N az ar eth , PA ( US) ; A01N 43/80 ( 2006 -01)
Kar en W ink oW s k i, Spr ing ? eld, N ] ( U S) A01N 4 7 /12 ( 2006 -01)
( 5 2) US. Cl.
( 7 3) As s ig nee: ISP IN VESTMEN TS IN C. , CPC . . . . . . . . . . . . . . . . A01N 43/38 ( 2013. 01) ; A01N 47 /12
W ilm ing ton, D E ( US) ( 2013. 01) ; A01N 43/7 8 ( 2013. 01) ; A01N 43/80
( 2013. 01)
( 21) Appl. N o. : 13/817 , 29 4 USPC . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 14/36 5 ; 5 14/417 ; 5 14/37 2
( 22) PCT Filed: Aug . 5 , 2011 ( 5 7 ) ABSTRACT
A th er m o-s table, ar s enic-f r ee s y ner g is tic biocide concentr ate
( 86 ) PCT N o. : PCT/US11/46 6 88 com pos ition to af f or d enh anced antim icr obial pr oper ties to a
poly m er m atr ix com pr is ing ( i) a m ix tur e of tr ih alom eth y l
37 1 ( 6 ) 0) th io- h th alim ide analo ue and a s econd biocide ( ii) an anti
( 2) , ( 4) D ate: Apr . 12, 2013 P g
Related US. Application D ata
( 6 0) Pr ov is ional application N o. 6 1/37 4, 433, ? led on Aug .
17 , 2010.
ox idant; ( iii) a car r ier ; and ( iv ) optionally , one or m or e addi
tiv es . Th e com pos ition is capable of w ith s tanding h ig h
pr oces s ing tem per atur es up to about 25 00 C. , s ubs tantially
W ith out th er m al deg r adation of biocides and dis color ation of
th e poly m er m atr ix em ploy ed.
US 2013/0310428 A1
THERMO-STABLE, ARSEN IC-FREE
SYN ERGISTIC BIOCID E CON CEN TRATE
COMPOSITION FOR POLYMER MATRICES
AN D PROCESS FOR PREPARIN G SAME
FIELD OF THE IN VEN TION
[ 0001] Th e pr es ent application r elates to biocide concen
tr ate com pos itions , and m or e par ticular ly , to a th er m o-s table,
ar s enic-f r ee biocide concentr ate com pos ition com pr is ing at
leas t one biocide s elected f r om tr ih alom eth y l-th io-ph th alim
ide and a s econd biocide.
BACKGROUN D OF THE IN VEN TION
[ 0002] Plas tics or poly m er s h av e becom e W ell r ecog niz ed
m ater ials f or m anuf actur ing v ar ious ty pes of ar ticles in th e
? elds of ? or al, m edical, indus tr ial and th e lik e. Th es e plas tics
ar e ty pically m ade of poly m er s and additiv es . Ty pical poly
m er s include, W ith out lim itation v iny ls , acr y lics , s ty r enes ,
poly ole? ns , poly ur eth anes , poly car bonates , poly am ides , im i
des , etc. In th e m anuf actur e of plas tics , plas ticiZ er s s uch as
ph th alates , adipates , es ter s , etc. ty pically ar e added as one of
th e additiv es to im pr ov e th e ph y s ical ch ar acter is tics of th e
r es ulting poly m er s and th es e plas ticiZ er s m ay be s us ceptible
to m icr obial attack . Als o, th er e ar e oth er nutr ient bear ing
ing r edients s uch as W ood, cellulos ics , r ice-h ull, etc. th at m ay
be added to pr oduce th e plas tic f or m ulations W h ich can m ak e
th em s us ceptible to m icr obial attack .
[ 0003] As a r es ult, in m any applications , th e poly m er ic or
plas tic m ater ials , or an item contained in a poly m er ic or
plas tic ar ticle m ade th er ef r om m ay be pr one to attack and
contam ination by m icr oor g anis m s s uch as bacter ia and/or
f ung i due to th e s us ceptibility of plas ticiZ er s to m icr oor g an
is m s . Th is m icr obial attack not only af f ects th e aes th etic of
th e pr oduct, but m ay als o r es ult in unpleas ant odor s , s taining ,
em br ittlem ent of th e plas tics and can ev entually lead to an
f ailur e pr oduct. Par ticular ly , actinom y cetes can g r oW on th e
s ur f aces of poly m er ic m ater ials and can pr oduce dy es as a
by pr oduct W h ich is s oluble in plas ticiZ er s em ploy ed in th e
m anuf actur e of poly m er ic m ater ials . Fur th er , actinom y cetes
can m ig r ate th r oug h th e s ubs tance v ia th e plas ticiZ er , r es ult
ing in th e ph enom enon k noW n as pink s taining . Addition
ally , th e s ur f ace g r oW th of m icr oor g anis m s on poly m er ic
m ater ials m ay h inder f unctional per f or m ance, f or ins tance
W h en us ed as lubr icating s ur f aces . So, a poly m er ic or plas tic
m ater ial capable of des tr oy ing or inh ibiting f or eig n m icr oor
g anis m s W ould be des ir able. Hence, th e integ r ation of a bio
cidal activ e ing r edient into th es e ty pe of poly m er ic m ater ials
is W idely ex plor ed and th es e biocide integ r ated poly m er ic
m ater ials ar e us ed in v ar ious ty pes of end-us e applications to
of f er adv antag eous r es ults W ith r eg ar d to g r oW th of bacter ia
or f ung i.
[ 0004] Many of th e indus tr ial biocides cur r ently us ed in
connection W ith plas tics , poly m er s and cellulos ic ? ber s ar e
or g anom etallics . One of th e m os t com m er cially us ed biocides
is 10, 10-ox y bis ph enox ar s ine ( OPBA) , W h ich is v er y ef f ec
tiv e in pr ev enting m icr obial attack on s uch m ater ials and cos t
ef f ectiv e. Becaus e of its h ig h ly leach able pr oper ty , it of f er s an
ef f ectiv e Z one of inh ibition in acceler ated m icr obial tes ting
and it als o h as th e ability to W ith s tand h ig h pr oces s ing tem
per atur e r ang es in th e m anuf actur e of plas tics or poly m er ic
m ater ials . HoW ev er , s uch com pounds m ay not be s uitable f or
m any indus tr ial applications . Th us , th er e is a need f or alter
N ov . 21, 2013
nativ e h eav y m etal-f r ee biocide pr oducts th at W ould of f er
s im ilar or better pr otection th an OPBA.
[ 0005 ] PCT Publication N o. W O2008047 09 7 as s ig ned to
Sy ng enta Par ticipations AG dis clos es an antif ung al coating
com pos ition, in par ticular paint, capable of contr olling f ung i
on an indus tr ial m ater ial. Th e publication des cr ibes com po
s itions com pr is ing : ( A) an is oth iaZ olone; ( B) th iabendaZ ole
and ( C) pr opiconaZ ole and W h er ein a par ticular em bodim ent
r ev eals th at ( A) , ( B) and ( C) ar e pr es ent in am ounts W h ich
pr oduce a s y ner g is tic f ung icidal ef f ect.
[ 0006 ] PCT Publication N o. W O2007 03119 8 as s ig ned to
Lanx es s D euts ch land GMBH dis clos es s y ner g is tic m ix tur es
bas ed on th e activ e s ubs tance tr iclos an W h ich ar e par ticular ly
s uitable f or pr otecting tech nical m ater ials ag ains t attack s ,
dam ag e, and/or des tr uction by m icr o-or g anis m s , in par ticu
lar , f or pr otecting W ood and W ood m ater ials ag ains t attack s
and/or des tr uction by lig niv or ous f ung i.
[ 0007 ] US. Patent Publication N o. 2006 0013833 as s ig ned
to ISP Inv es tm ents Inc. dis clos es a com pos ition W h ich
includes ( a) a m atr ix , ( b) a biocide, and ( c) an antiox idant, in
W h ich s aid biocide ex h ibits th er m al s tability at m atr ix pr o
ces s ing tem per atur es of up to 25 00 C.
[ 0008] US. Pat. N o. 5 , 023, 281 as s ig ned to Mor ton Inter
national, Inc. des cr ibes m icr obiocidal s olutions com pr is ing
an ar y l alk anol s olv ent and a m icr obiocidal com pound dis
s olv ed th er ein. Th e s olutions m ay be us ed to im par t m icr o
biocidal pr oper ties to poly m er com pos itions . Th e s elected
m icr obicidal com pounds ar e N -( 2-m eth y lnaph th y l) m aleim
ide, bis -N -[ 1, 1, 2, 2-tetr ach lor oeth y ) th io]-4-cy cloh ex ene-1, 2
dicar box im ide, N -tr ich lor om eth y lth io-4-cy cloh ex ene-1, 2
dicar box im ide, N -tr ich lor om eth y lth io ph th alim ide ( Folpet)
and 2-( n-octy l-4-is oth iaZ olin-3-one) ( BIT) .
[ 0009 ] US. Pat. N o. 5 , 319 , 000 as s ig ned to Olin Cor por a
tion dis clos es s tor ag e-s table dis per s ions of s olid biocides in
plas tis ols W h ich ar e pr ov ided by caus ing car r ier abs or ption
into th e poly m er to occur under elev ated tem per atur e condi
tions . Th e r es ulting dis per s ions ar e s tor ag e-s table ag ains t
s ettling and ag ains t s etting -up th at W ould oth er W is e tend to
occur dur ing W ar eh ous ing of th e dis per s ions pr ior to us e. Th e
dis clos ed biocides ar e s elected f r om th e g r oup cons is ting of
s odium py r ith ione, Z inc py r ith ione, ch itos an py r ith ione, and
com binations th er eof .
[ 0010] US. Pat. N o. 6 , 39 9 , 5 6 0 as s ig ned to N ov aph ar m
Res ear ch ( Aus tr alia) Pty Ltd dis clos es a biocidal concentr ate
including Z inc py r idineth ione; and a s econd biocide s elected
to be biocidally ef f ectiv e in a pH r ang e com plem entar y to Z inc
py r idineth ione. Th e s econd biocide m ay be an ar om atic h alo
g enated ph enol s uch as tr iclos an, dich lor oph en and tr ich lor
car ban. Th e inv ention als o pr ov ides biocidal cleaning dev ices
and plas tic m ater ials and m eth ods of m anuf actur e th er eof .
[ 0011] US. Pat. N o. 6 , 846 , 7 7 7 as s ig ned to Th or Gm bH
dis clos es a biocide com pos ition as an additiv e to m ater ials
capable of being attack ed by h ar m f ul m icr oor g anis m s , com
pr is ing as biocidal activ e ing r edients Z inc py r ith ione and
3-iodo-2-pr opiny l-N -buty lacar bam ate as W ell as 2-n-octy l
is oth iaZ olin-3-one or 4, 5 -dich lor o-2-n-octy lis oth iaZ olin-3
one or a m ix tur e of both .
[ 0012] PCT Publication N o. W O200813206 0 dis clos es th e
us e of a biocidal m ix tur e containing IPBC and TBZ f or th e
pr otection of W ood-plas tic com pos ites ( W PC) containing a
th er m oplas tic poly m er and W ood par ticles f r om inf es tation
and/or des tr uction by m icr oor g anis m s ; PCT Publication N o.
W O2010015 5 5 2 des cr ibes s table antif ung al liq uid f or m ula
tions f or pr otecting m ater ial, containing 3-iodopr opy ny l
US 2013/0310428 A1
buty l car bam ate ( IPBC) , n-octy lis oth iaZ olinone ( n-OIT) , and
a s olv ent th at h as a m inim um boiling point of 25 00 C. at th e
s tandar d pr es s ur e and contains at leas t tW o f unctional g r oups
s elected f r om am ong eth er g r oups , es ter g r oups , am ide
g r oups , or alcoh ol g r oups ; and Us . Pat. N o. 5 46 46 22 dis
clos es a s y ner g is tic antim icr obial com pos ition com pr is ing
2-m er captopy r idine N -ox ide, and s alts th er eof , and iodopr o
par g y l buty lcar bam ate ( IPBC) in a r atio to each oth er W h ich
ex h ibits s y ner g is m .
[ 0013] Accor ding ly , th e pr es ent application des cr ibes a
th er m o-s table, ar s enic-f r ee and s y ner g is tic biocide concen
tr ate com pos ition h av ing eq ual or better e? icacy th an W idely
utiliZ ed OPBA.
SUMMARY OF THE IN VEN TION
[ 0014] Th e pr es ent application r elates to a th er m o-s table,
ar s enic-f r ee s y ner g is tic biocide concentr ate com pos ition to
im par t enh anced m icr obicidal pr oper ties to a poly m er m atr ix
com pr is ing ( i) ( a) about 2. 5 to about 5 0. 0 W t % of tr ih alom
eth y l-th io-ph th alim ide and ( b) about 0. 5 to about 25 . 0 W t % of
a s econd biocide; ( ii) about 0. 5 to 20 W t % of an antiox idant;
( iii) a car r ier ; and ( iv ) optionally , one or m or e additiv es .
[ 0015 ] In accor dance W ith cer tain as pects , a biocide con
centr ate com pos ition is pr ov ided W h ich is capable of W ith
s tanding h ig h pr oces s ing tem per atur es up to about 25 00 C. ,
s ubs tantially W ith out th er m al deg r adation of th e biocide or
dis color ation of th e poly m er m atr ix pr es ent in th e end us e
applications .
[ 0016 ] In a pr ef er r ed as pect, N -[ ( tr ich lor om eth y l) -th io]
ph th alim ide is eng ag ed as a biocide of th e pr es ent concentr ate
com pos ition.
[ 0017 ] Anoth er as pect of th e pr es ent application is to
em ploy a s econd biocide along W ith N -[ ( tr ich lor om eth y l)
th io] -ph th alim ide pr ef er ably s elected f r om th e g r oup cons is t
ing of N -buty l-1, 2-benZ is oth iaZ olin-3-one ( BBIT) , 4, 5
dich lor o-n-octy l-4-is oth iaZ olin-3-one ( D COIT) , tr iclos an,
2-m eth y l-4-is oth iaZ olin-3-one ( MIT) , 1, 2-BenZ is oth iaZ olin
3-one ( BIT) , 5 -Ch lor o-2-m eth y l-4-is oth iaZ olin-3-one
( CMIT) , 2-Octy l-4-is oth iaZ olin-3-one ( OIT) , 3-iodo-2-pr o
py ny lbuty l-car bam ate ( IPBC) , ox y ? uor f en, 3-iodopr opy ny l
car bam ate ( IPC) , 3-iodopr opy ny l-N -ph eny l car bam ate
( IPPC) , th iabendaZ ole, ter butr y n, Z inc py r ith ione ( Z nPy ) ,
br onopol, diur on, deh y dr oacetic acid ( D HA) , daZ om et and/or
car bendaZ im .
[ 0018] In accor dance W ith anoth er as pect of th e pr es ent
application a s y ner g is tic biocide concentr ate com pos ition
W h ich is capable of ex h ibiting enh anced m icr obicidal activ ity
W ith v er y les s er q uantities of m ix tur e of tr ih alom eth y l-th io
ph th alim ide and a s econd biocide is pr ov ided.
[ 0019 ] Anoth er as pect of th e pr es ent application is to
em ploy an antiox idant s elected f r om th e g r oup cons is ting of
h inder ed ph enols , am ines , ar y l ph os ph ates , and/or aZ oles .
[ 0020] In accor dance W ith anoth er as pect of th e pr es ent
application, th e biocide concentr ate com pos ition is capable
of inh ibiting or k illing Staph y lococcus aur eus , Klebs iella
pneum onia, Ps eudom onas ar eug inos a, Bacillus s ubtilus ,
As per g illus nig er , As per g illus ? av us , Os cillator ia tennis ,
Penicillin f uniculos um , Ch aetom ium g lobos um , Aur eoba
s idium pullulans , Tr ich oder m a altler nar ia alter nata, Cur v u
lar ia s p. , Fus ar ium s p. , N ig r os por a s p. , Helm inth os por ium
Clados por ium s p. , Gliocladium and/or . Str eptov er ticillium
r eticulum .
[ 0021] In y et anoth er as pect, th e additiv es f or pr epar ing th e
des ir ed biocide concentr ate com pos ition m ay be s elected
N ov . 21, 2013
f r om th e g r oup cons is ting of color ants , pig m ents , th er m al
s tabiliZ er s , ultr av iolet s tabiliZ er s , r adiation s tabiliZ er s , m old
r eleas e additiv es , ig nition r es is tant additiv es , ? ller s , r einf or c
ing aids , bloW ing ag ents , plas ticiZ er s , ? oW enh ancer s , lubr i
cants , anti-f og g ing ag ents , anti-s tatic com pos itions , anti
block ing com pounds , lubr icants , h eat s tabiliZ er s , coupling
ag ents , ex tender s , im pact m odi? er s , g las s ? ber s ? am e r etar
dants W ood, W ood ? our and/or s lip ag ents .
D ETAILED D ESCRIPTION OF THE IN VEN TION
[ 0022] W h ile th is s peci? cation concludes W ith claim s par
ticular ly pointing out and dis tinctly claim ing th at W h ich is
r eg ar ded as th e inv ention, it is anticipated th at th e inv ention
can be m or e r eadily under s tood th r oug h r eading th e f olloW ing
detailed des cr iption of th e inv ention and s tudy of th e included
ex am ples .
[ 0023] By th e ter m com pr is ing h er ein is m ean th at v ar i
ous optional, com patible com ponents can be us ed in th e com
pos itions h er ein, pr ov ided th at th e im por tant ing r edients ar e
pr es ent in th e s uitable f or m and concentr ations . Th e ter m
com pr is ing th us encom pas s es and includes th e m or e
r es tr ictiv e ter m s cons is ting of and cons is ting es s entially
of W h ich can be us ed to ch ar acter iz e th e es s ential ing r edients
s uch as biocide, antiox idant and additiv es if any of th e biocide
concentr ate com pos ition.
[ 0024] All per centag es , par ts , pr opor tions and r atios as
us ed h er ein, ar e by W eig h t of th e total com pos ition, unles s
oth er W is e s peci? ed. All s uch W eig h ts as th ey per tain to lis ted
ing r edients ar e bas ed on th e activ e lev el and, th er ef or e, do not
include s olv ents or by -pr oducts th at m ay be included in com
m er cially av ailable m ater ials , unles s oth er W is e s peci? ed.
[ 0025 ] All r ef er ences to s ing ular ch ar acter is tics or lim ita
tions of th e pr es ent application s h all include th e cor r es pond
ing plur al ch ar acter is tic or lim itation, and v ice-v er s a, unles s
oth er W is e s peci? ed or clear ly im plied to th e contr ar y by th e
contex t in W h ich th e r ef er ence is m ade.
[ 0026 ] N um er ical r ang es as us ed h er ein ar e intended to
include ev er y num ber and s ubs et of num ber s contained
W ith in th at r ang e, W h eth er s peci? cally dis clos ed or not. Fur
th er , th es e num er ical r ang es s h ould be cons tr ued as pr ov iding
s uppor t f or a claim dir ected to any num ber or s ubs et of num
ber s in th at r ang e.
[ 0027 ] All publications , ar ticles , paper s , patents , patent
publications , and oth er r ef er ences cited h er ein ar e h er eby
incor por ated h er ein in th eir entir eties f or all pur pos es to th e
ex tent cons is tent W ith th e dis clos ur e h er ein.
[ 0028] Th e ter m ar s enic-f r ee m eans th at th e biocide con
centr ate com pos ition is f r ee f r om ar s enic in any f or m , par
ticular ly th e s alts of ar s enic s uch as or g anic bound ar s enic or
inor g anic bound ar s enic.
[ 0029 ] Th e ter m th er ' m o-s table m eans th at th e biocides
pr es ent in th e concentr ate com pos ition is s table at its elev ated
pr oces s ing tem per atur e of about 25 00 C.
[ 0030] Th e ter m f olpet analog ues and tr ih alog enom eth
y lth io ph th alim ide analog ues ar e s y nony m ous ly us ed
th r oug h out th is application.
[ 0031] Th e ter m h inder ed ph enolic antiox idant as us ed
h er ein r ef er s to a com pound h av ing at leas t one ph enolic
s ubs tituent, in W h ich th e tW o pos itions or th o to th e ph enolic
h y dr ox y l g r oup ar e s ubs tituted, pr ef er ably W ith a ter tiar y
alk y l g r oup. Th e par a pos ition is pr ef er ably s ubs tituted W ith
an alk y l g r oup containing at leas t tW o h y dr og ens at th e alph a
pos itions to th e par a s ubs tituted alk y l g r oup.
US 2013/0310428 A1
[ 0032] Th e ter m biocide or antim icr obial as us ed
h er ein is to be under s tood to r ef er to ag ents s uch as g er m i
cides , bacter icides , f ung icides , alg icides , aq uaticides , h er bi
cide, ins ecticide, lar v icide, pes ticide, r odenticide, taeniacide,
plant g r ow th r eg ulator s and th e lik e, W h ich ar e us ed f or th eir
ability to inh ibit g r oW th of and/or des tr oy biolog ical and/or
m icr obiolog ical s pecies s uch as bacter ia, f ung i, alg ae, cater
pillar , ins ects , lar v ae, m ildeW , r odents , s pider , W or m and th e
lik e.
[ 0033] As us ed h er ein, th e ter m s y ner g is tic r ef er s to cas es
W h er e th e e? icacy of a biocide concentr ate com pos ition com
pr is ing tW o dif f er ent biocidal ag ents ex ceeds th e s um of th e
antim icr obial ef ? cacies of th e indiv idual antim icr obial ag ents
em ploy ed alone. Th er ef or e, us ing a s y ner g is tic antim icr obial
com pos ition can alloW f or th e us e of a loW er ov er all concen
tr ation of antim icr obial ag ent to pr ov ide f or enh anced anti
m icr obial e? icacy at com par able antim icr obial concentr a
tions .
[ 0034] In a par ticular em bodim ent of th e pr es ent applica
tion, at leas t one biocide is s elected f r om tr ih alom eth y l-th io
ph th alim ide analog ues to pr epar e th e biocide concentr ate
com pos ition. Th e pr ef er r ed tr ih alom eth y l-th io-ph th alim ide
analog ues W ould include but ar e not lim ited to captan,
captaf ol, dich lo? uanid, toly ? uanid, f olpet and/ or ? uor f olpet.
Th e m o s t pr ef er r ed tr ih alom eth y l-th io -ph th alim ide analog ue
is tr ich lor om eth y l-th io-ph th alim ide ( Folpet) . Th e lev els of
tr ih alom eth y l-th io-ph th alim ide analog ues em ploy ed in th e
pr es ent application m ay be f r om about 2. 5 to about 5 0. 0 W t %
of th e total W t % of th e com pos ition.
[ 0035 ] Th e s uitable s econd biocide em ploy ed to pr epar e
th e biocide concentr ate com pos ition m ay be s elected f r om ,
but is not lim ited to, g er m icides , bacter icides , f ung icides ,
alg icides , aq uaticides , h er bicides , ins ecticides , lar v icides ,
pes ticides , r odenticides , m ollus cicides and/or taeniacides .
Fur th er , th e lev els of s econd biocide em ploy ed in th e pr es ent
application m ay be f r om about 0. 5 to about 25 . 0 W t % of th e
total W t % of th e com pos ition.
[ 0036 ] Accor ding to par ticular em bodim ent of th e pr es ent
application, th e s econd biocide em ploy ed to pr epar e th e bio
cide concentr ate com pos ition is s elected f r om f olloW ing non
lim iting g r oup of biocidal com pounds : Tr iaZ oles : AZ acona
Z ole, br om uconaZ ole, cy pr oconaZ ole, dich lobutr aZ ol,
diniconaZ ole, h eX conaZ ole, m etconaZ ole, penconaZ ole,
pr opiconaZ ole, tebuconaZ ole, am itr ole, aZ ocy clotin, epox y
conaZ ole, biter tanol, dif enoconaZ ole, f enbuconaZ ole,
f ench lor aZ ole, f eneth anil, ? uq uinconaZ ole, ? us ilaZ ole, ? utr i
af ol, im ibenconaZ ole, is oZ of os , m y clobutanil, paclobutr aZ ol,
( + ) -cis -1-( 4-ch lor oph eny l) -2-( 1H-l, 2, 4-tr iaZ ol-1-y l) -cy clo
h eptanol, tetr aconaZ ole, tr iadim ef on, tr iadim enol, tr iapen
th enol, tr i? um iZ ole, tr iticonaZ ole, uniconaZ ole and th eir
m etal s alts and acid adducts ; Im idaZ oles : Im aZ alil, pef ur a
Z oatc, pr och lor aZ , tr i? um iZ ole. h iaZ olecar boX anilides , 2' , 6 '
dibr om o-2-m eth y l-4-tr i ? uor om eth ox y -4' -tr i? uor om eth y l
1, 3-th iaZ ole-5 -car boX anilide and th eir m etal s alts and acid
adducts . Succinate deh y dr og enas e inh ibitor s : Fenf ur am , f ur
car banil, cy cla? ur am id, f ur m ecy clox , s eedv ax , m ets ulf ov ax ,
py r ocar bolid, ox y car box in, Sh ir lan, m ebenil ( m epr onil) ,
benodanil, ? utolanil ( Moncut) ; N aph th alene der iv ativ es : Ter
bina? ne, naf ti? ne, butena? ne; 10, 10 ox y bis ph enox ar s ine;
BenZ im idaZ oles : car bendaZ im , benom y l, f ur ath iocar b,
f uber idaZ ole, th ioph onatm eth y l, th iabendaZ ole or s alts
th er eof ; Mor ph oline der iv ativ es : tr idem or ph , f enpr opim or ph ,
f alim or ph , dim eth om or ph , dodem or ph ; aldim or ph , f enpr opi
din and th eir s alts W ith ar y ls ulph onic acids , s uch as p-tolu
N ov . 21, 2013
enes ulph onic acid and p-dodecy lph eny l-s ulph onic acid;
D ith iocar bam ates : cuf r aneb, f er bam , m ancopper , m ancoZ eb,
m aneb, m etam , m etir am , th ir am Z eneb, Z ir am ; BenZ oth iaZ
oles : 2-m er captobenZ oth iaZ ole; BenZ am ides : 2, 6 -dich lor o
N -( 4-tr i? uor om eth y lbenZ y l) -benZ am ide; Bor on com pounds :
bor ic acid, bor ic es ter s , bor ax ; For m aldeh y de donor s : benZ y l
alcoh ol m ono-( poly ) -h em if or m al, oX aZ olidines , h eX a-h y dr o
5 -tr iaZ ines , N -m eth y lolch lor acetam ide, par af or m adeh y de,
nitr opy r ine, ox olic acid, teclof talam ; Tr is -N -( cy cloh ex y ldia
Z enium dioX y ) -alum inium , N -( cy clo-h eX y ldiaZ enium diox y )
tr ibuty l, K s alts ; Is oth iaZ olones : N -Meth y lis oth iaZ olin-3 -one
( MIT) , 5 -Ch lor o-2-m eth y l-4-is oth iaZ olin-3-one ( CMIT) ,
4, 5 -dich lor o-N -octy lis oth iaZ olin-3-one ( D COIT) , 2-Octy l
4-is oth iaZ olin-3-one ( OIT) , 4, 5 -tr im eth y lene-is oth iaZ oli
none, 1, 2-BenZ is oth iaZ olin-3-one ( BIT) , N -buty l-1, 2-ben
Z is oth iaZ olin-3-one ( BBIT) , ; Aldeh y des , s uch as
cinnam aldeh y de, f or m aldeh y de, g lutar dialdeh y de, [ 3-Br -cin
nam aldeh y de; Th iocy anates : th iocy anatom eth y lth ioben
Z oth iaZ ole, m eth y lenebis th iocy anate, and th e lik e; Q uater
nar y am m onium com pounds :
benZ y ldim eth y ltetr adecy lam m onium ch lor ide, benZ y ldim
eth y ldodecy lam m onium ch lor ide, didecy ldim eth y lam m o
nium ch lor ide; Iodine der iv ativ es : diiodom eth y l p-toly l s ul
ph one, 3-iodo-2-pr opiny l alcoh ol, 4-ch lor oph eny l-3
iodopr opar g y l f or m al, 3-br om o-2, 3-diiodo-2-pr openy l
eth y lcar bam ate, 2, 3, 3-tr iiodoally l alcoh ol, 3-br om o-2, 3-di
iodo-2-pr openy l alcoh ol, 3-iodo-2-pr opy ny l-n-buty lcar bam
ate ( IPBC) , 3-iodo-2-pr opiny l-n-buty lur ea, 3-iodo-2-pr opi
ny l-n-h ex y lcar bam ate, 3 -iodo -2 -pr opiny l
cy cloh ex y lcar bam ate, 3 -iodo -2-pr opiny l-N
ph eny lcar bam ate ( IPPC) ; Ph enol der iv ativ es :
tr ibr om oph enol, tetr ach lor oph enol, 3-m eth y l-4-ch lor oph e
nol, 3, 5 -dim eth y l-4-ch lor oph enol, ph enox y eth anol, dich lo
r oph en, o-ph eny lph enol, m -ph eny lph enol, p-ph eny lph enol,
2-benZ y l-4 -ch lor oph enol and th eir alk ali m etal s alts and alk a
line ear th m etal s alts ; Micr obicides : ch lor oacetam ide, N -m e
th y lolch lor oacetam ide, br onopol, br onidox , tectam er includ
ing 2-br om o-2-nitr o-1, 3-pr opanediol, 2-br om o-4' -h y dr ox y
acetoph enone, 2, 2-dibr om o-3-nitr ilo-pr opionam ide, 1, 2
dibr om o-2, 4-dicy anobutane, [ 3-[ 3-[ 3-nitr os ty r ene; Py r idines :
1-h y dr oX y -2-py r idineth ione and/or th eir N a, Fe, Cu, Mn, Z n
s alts th er eof , Z inc py r ith ione ( Z nPy ) tetr ach lor o-4-m eth y l
s ulph ony lpy r idine, py r im eth anol, m epanipy r im , dipy
r ith ione; D ialk y ldith iocar bam ates : s odium s alts of dialk y
ldith iocar bam ates , tetr am eth y lth iur am dis ulph ide, potas s ium
N -m eth y l-dith iocar bam ate; N itr iles : 2, 4, 5 , 6 -tetr ach lor
ois oph th alonitr ile, dis odium cy ano-dith ioim idocar bam ate;
Q uinolines : 8-h y dr ox y q uinoline and th eir inor g anic s alts
th er eof , par ticular ly , Cu s alt; Oth er Biocides : Mucoch lor ie
acid, 5 -h y dr oX y -2( 5 H) -f ur anone, 4, 5 -D ich lor odith iaZ oli
none, 4, 5 -benZ odith iaZ olinone, 4, 5 -tr im eth y lenedith iaZ oli
none, 4, 5 -dich lor o-( 3H) -1, 2-dith iol-3-one, 3, 5 -dim eth y l-tet
r ah y dr o-1, 3, 5 -th iadiaZ ine-2-th ione, N -( 2 -p
Ch lor obenZ oy leth y l) -h eX am inium ch lor ide, potas s ium
N -h y dr ox y m eth y l-N ' -m eth y l-dith iocar bam ate, 2-OX o-2-( 4
h y dr oX y -ph eny l) aceth y dr ox im ic acid ch lor ide, Ph eny l
2-ch lor o-cy ano-v iny l s ulph one, Ph eny l 1, 2-dich lor o-2-cy
ano-v iny l s ulph one, tr iclos an, deh y dr oacetic acid ( D HA) .
[ 0037 ] Fung icides : Meth y l( E) -m eth ox im ino[ ot-( o-toly
lox y ) -o-toly l] acetate, m eth y l( E) -2-{ 2-[ 6 -( 2-cy anoph enox y )
py r im idin-4-y l-ox y ]ph eny l} -3-m eth ox y aer y late, Acy petacs ,
2-am inobutane, am pr opy lf os , anilaZ ine, benalax y l, bupir i
m ate, ch inom eth ionat, ch lor oneb, ch loZ olinate, cy m ox anil,
daZ om et, diclom eZ inc, dich lor am , dieth of encar b, dim eth ir i
US 2013/0310428 A1
m ol, diocab, dith ianon, dodine, dr aZ oX olon, edif enph os ,
eth ir im ol, etr idiaZ ole, f enar im ol, f enitr opan, f entin acetate,
f entin h y dr ox ide, f er im Z one, ? uaZ inam , ? uor or m ide, ? us ul
f am ide, ? utr iaf ol, f os ety l, f th alide, f ur alax y l, g uaZ atine,
h y m eX aZ ol, ipr obenf os , ipr odione, is opr oth iolane, m etalax y l,
m eth as ulf ocar b, nitr oth al-is opr opy l, nuar im ol, of ur ace, ox a
diy l, per ? ur aZ oate, pency cur on, ph os diph en, pim ar icin, pip
er alin, pr ocy m idone, pr opam ocar b, pr opineb, py r aZ oph os ,
py r if enox , py r oq uilon, q uintoZ ene, tar oils , tecnaZ ene, th icy
of en, th ioph anate-m eth y l, tolclof os -m eth y l, tr iaZ oX ide,
tr ich lam ide, tr icy claZ ole, tr if or ine, VincloZ olin.
[ 0038] Ins ecticides : ( i) Ph os ph ates : aZ inph os -eth y l, aZ in
ph os -m eth y l, ot-l( 4-ch lor oph eny l) -4-( O-eth y l, S-pr opy l)
ph os ph or y lox y -py r aZ ole, ch lor py r if os , coum aph os , dem e
ton, dem eton-S-m eth y l, diaZ inon, dich lor v os , dim eth oate,
eth oate, eth opr oph os , etr im f os , f enitr oth ion, f enth ion, h ep
tenoph as , par ath ion, par ath ion-m eth y l, ph os alone, ph ox im ,
pir im iph os -eth y l, pir im iph os -m eth y l, pr of enof os , pr oth iof os ,
s ulf pr of os , tr iaZ oph os and tr ich lor ph on; ( ii) Car bam ates :
aldicar b, bendiocar b, ot-2-( 1-m eth y lpr opy l) -ph eny l m eth y l
car bam ate, butocar box im , butox y car box im , car bar y l, car bo
f ur an, car bos ulf an, cloeth ocar b, is opr ocar b, m eth om y l,
ox am y l, pir im icar b, pr om ecar b, pr opox ur and th iodicar b;
( iii) Or g anos ilicon com pounds : pr ef er ably dim eth y l( ph eny l)
s ily l-m eth y l 3-ph enoX y benZ y l eth er s s uch as dim eth y l
( 4eth oX y ph eny l) -s ily l-m eth y l 3-ph enoX y benZ y l eth er , or
( dim eth y lph eny l) -s ily l-m eth y l 2-ph enox y -6 -py r idy lm eth y l
eth er s , s uch as e. g . dim eth y l-( 9 -eth oX y -ph eny l) -s ily lm eth y l
2-ph enox y -6 -py r idy lm eth y l eth er or [ ( ph eny l) -3-( 3-ph enox
y ph eny l) -pr opy l]( dim eth y l) -s ilanes , s uch as e. g . ( 4-eth ox
y ph eny l) -[ 3-( 4-? uor o-3-ph enoX y ph eny l-pr opy l]dim eth y l
s ilane, s ila? uof en; ( iv ) Py r eth r oids : alleth in, alph am eth r in,
bior es m eth r in, by f enth r in, cy clopr oth r in, cy ? uth r in, deca
m eth r in, cy h aloth r in, cy per m eth r in, deltam eth r in, ot-cy ano
3-pr opancar box y late, f enpr opath r in, f en? uth r in, f env aler ate,
? ucy th r inate, ? um eth r in, ? uv alinate, per m eth r in, r es m eth r in
and tr alom eth r in; ( V) N itr oim ines and nitr om eth y lenes : 1 -[ ( 6
ch lor o -3 -py r idiny l) -m eth y l] -4, 5 -dih y dr o -N -nitr o- 1 H-im ida
Z ole-2-am ine( im idaclopr id) , N -[ ( 6 -ch lor o-3-py r idy l) m e
th y l-]N 2 -cy ano -N l -m eth y lacetam ide; ( Vi) Oth er s :
Abam ectin, aceph ate, acr inath r in, alany car b, aldox y car b,
aldr in, am itr aZ , aZ am eth iph os , bacillus th ur ing iens is , ph os
m et, ph os ph am idon, ph os ph ine, pr alleth r in, pr opaph os , pr o
petam ph os , pr oth oate, py r aclof os , py r eth r ins , py r idaben,
py r idaf enth ion, py r ipr ox y f en, q uinalph os , RH-7 9 88, r oten
one, s odium ? uor ide, s odium h ex a? uor os ilicate, s ulf otep,
s ulph ur y l ? uor ide, tar oils , te? ubenZ ur on, te? uth r in, tem e
ph os , ter buf os , tetr ach lor v inph os , tetr am eth r in, O-2-ter t-bu
ty l-py r im idin-5 -y l-o-is opr opy l-ph os ph or oth iate, th iocy
clam , th iof anox , th iom eton, tr alom eth r in, tr i? um ur on,
tr im eth acar b, Vam idoth ion, Ver ticillium lacanii, X MC, X y ly l
car b, benf ur acar b, bens ultap, bif enth r in, bioalleth r in, MER
bioalleth r in ( S) -cy clopenteny l is om er , br om oph os , br o
m oph os -eth y l, bupr of eZ in, cadus af os , calcium poly s ulph ide,
car boph enoth ion, car tap, ch inom eth ionat, ch lor dane, ch lor
f env inph os , ch lor ? uaZ ur on, ch lor m eph os , ch lor opicr in, ch lo
r py r if os , cy anoph os , beta-cy ? uth r in, ot-cy per m eth r in,
cy oph enoth r in, cy r om aZ ine, daZ om et, D D T, dem eton-5 -m e
th y ls ulph on, diaf enth iur on, dialif os , dicr otoph os , di? uben
Z ur on, dinos eb, deoX abenZ of os , diax acar b, dis ulf oton,
D N OC, em penth r in, endos ulf an, EPN , es f env aler ate,
eth iof encar b, eth ion, etof enpr ox , f enobucar b, f enox y car b,
f ens ulf oth ion, ? pr onil, ? ucy clox ur on, ? uf enpr ox , ? uf enox u
r on, f onof os , f or m etanate, f or m oth ion, f os m eth ilan, f ur ath io
N ov . 21, 2013
car b, h eptach lor , h ex a? um ur on, h y dr am eth y lnon, h y dr og en
cy anide, h y dr opr ene, IPSP, is aZ of os , is of enph os , is opr oth i
olane, is ox ath ion, iodf enph os , k adeth r in, lindane, m alath ion,
m ecar bam , m eph os f olan, m er cur ous , ch lor ide, m etam ,
Metar th iZ ium , anis opliae, m eth acr if os , m eth am idoph os ,
m eth idath ion, m eth iocar b, m eth opr ene, m eth ox y ch lor ,
m eth y l is oth iocy anate, m eth olcar b, m ev inph os , m onocr oto
ph os , naled, N eodipr ion s er tif er N PV, nicotine, om eth oate,
ox y dem eton-m eth y l, pentach lor oph enol, petr oleum oils ,
ph enoth r in, ph enth oate, ph or ate.
[ 0039 ] Her bicides : acetoch lor , aci? uor f en, aclonif en,
acr olein, alach lor , allox y dim , am etr y n, am idos ulf ur on,
am itr ol, am m onium s ulf ate, anilof os , as ulam , atr aZ ine,
aZ ipr otr y n, benaZ olin, ben? ur alin, benf ur es ate, bens ulf ur on,
bens ulide, benZ taZ one, ch lor idaZ on, ch lor im ur on, ch lo
r om eth ox y f en, ch lor onitr of en, ch lor oacetic acid, ch lor opi
cr in, ch lor otolur on, ch loox ur on, ch lor opr eph am , ch lor os ul
f ur on, ch lor oth al, ch lor oth iam ide, cinm eth y line,
cinos ulf ur on, cleth odim , clom aZ one, clom epr op, clopy r alid,
cy anam ide, cy anaZ ine, cy cloate, cy clox y dim , benZ of encap,
benZ th iaZ ur on, bif enox , bilanaf os , bor ax , br om acil, br o
m obutide, br om of enox im , br om ox y nil, butach lor , butam if os ,
butanach lor , butr alin, buty late, car betam ide, CGA 1849 27 ,
ch lor am ben, ch lor obr om ur on, ch lor obuf am , ch lor o? ur enol,
dif enox ur on, dif enZ oq uat, di? uf enican, dim ef ur on, dim epip
er ate, dim eth ach lor , dim eth am etr y n, dim eth ipin, dim eth y
lar s enic acid, dinitr am in, dinos eb acetate, dinos eb, dinoter b,
diph enam ide, dipr opetr y n, diq uat, dith iopy r , diur on, D N OC,
PPX -A7 88, 2, 4-D , daim ur on, dalapon, daz om et, 2, 4-D B,
des m ediph am , des m etr y n, dicam ba, dich lobenil, dich lor o
pr op, dich lor opr op-P, diclof op, dieth aty l, ? am pr op-M, ? aZ a
s ulf ur on, ? uaZ if op, ? uaZ if op-P, ? uch lor alin, ? um etur on,
? uor og ly cof en, ? uor onitr of en, ? upr opanate, ? ur enol, ? ur i
don, ? uor och lor idon, ? ur ox y py r , f om os af en, f us am in, f ur y
lox y f en, g luf os inate, g ly ph os ate, h alox y f op, h eX aZ inon,
im aZ am eth abenZ , im aZ apy r , im aZ aq uin, im aZ eth apy r , iox y
nil, is opr opalin, is opr otur on, is our on, is ox aben, is ox apy r i
f op, lactof en, lenacil, linur on, LS8305 5 6 , MCPA, pebulat,
pendim eth alin, pentach lor oph enol, pentanoch lor , m iner al oil
f r actions , ph enm ediph am , piclor am , piper oph os , pr eti
lach lor , pr im is ulf ur on, pr odiam in, pr og linaZ in, pr om eton,
pr om etr y n, pr opach lor , pr opanil, pr opaq uiZ af op, pr opaZ ir ,
pr oph am , pr opy Z am ide, pr os ulf ocar b, py r aZ oly nate, py r aZ o
s ulf ur on, py r aZ ox y f en, py r ibuticar b, py r idat, q uinclor ac,
q uinm er ac, q uinoclam in, q uiZ alof op, q uiZ alof op-P, S-23121,
D PX -E9 6 36 1, D SMA, eg linaZ ine, endoth al, eps or car b,
EPTC, eth al? ur alin, eth idim ur on, eth of um es ate, f enox apr op,
f enox apr op-P, lem on, ? am pr op, ir g ar ol 105 1, MCPA-th ioet
h y l, MCPB, m ecopr op, m ecopr op-P, m ef enacet, m e? uidid,
m etam , m etam itr on, m etaZ ach lor , m eth abenZ th iaZ ur on, m et
h aZ ole, m eth opr otr y n, m eth y ldy m r on, m eth y l is oth iocy an
ate, m etobr om ur on, m etolach lor , m etox uon, m etr ibuZ in, m et
s ulf ur on, m olinate, m onoalid, m onolinur on, MSMA,
napr oanilide, napr opam ide, naptalam , nebur on, nicos ulf u
r on, nipy r aclof en, nor ? ur aZ on, or bencar b, or y Z alin, ox adia
Z on, ox y ? uor f en, par aq uat, pr om etr y n, s im etr y n, SMY 15 00,
s odium ch lor ate, s ulf om etur on, tar oils , TCA, tebutam ,
tebuth iur on, ter bacil, ter bum eton, ter buth y laZ ine, ter butr y n,
th iaZ a? ur on, th if ens ulf ur on, th iobencar b, th iocar baZ il, tio
clor im , tr alk ox y dim , tr i-allate, tr ias ulf ur on, tr ibenZ ur on, tr i
clopy r , tr idiph ane, tr ietaZ ine, tr i? ur alin, UB1-C487 4, Vem o
late. Mollus cicides : Fentin acetate, m etaldeh y de,
m eth iocar b, niclos am ide, th iodicar b, tr im eth acar b. Alg i
cides : copper s ulph ate, dich lor or ph en, endoth al, f entin
US 2013/0310428 A1
acetate, q uinoclam ine. Additional biocides th at ar e des cr ibed
in R. Gach ter and H. Muller , Ham er Ver lag , 3r d edition, 19 9 0,
pag es 7 9 1-809 can als o be s elected f or th e pur pos es of th e
application as a s econd biocide.
[ 0040] In accor dance W ith one as pect, a s y ner g is tic biocide
concentr ate com pos ition W h ich is capable of ex h ibiting
enh anced m icr obicidal activ ity com pr is ing a m ix tur e of tr i
h alom eth y l-th io-ph th alim ide and a s econd biocide W h ich is
ef f ectiv e at r elativ ely loW concentr ations is pr ov ided. Par ticu
lar ly us ef ul s y ner g is tic biocide com binations em ploy ed in th e
pr es ent biocide concentr ate com pos ition include, but ar e not
lim ited to, Folpet/N -buty l-1 , 2-benZ is oth iaZ olin-3 -one
( BBIT) , Folpet/4, 5 -dich lor o-n-octy l-4-is oth iaZ olin-3 -one
( D COIT) , Folpet/tr iclos an, Folpet/2-m eth y l-4-is oth iaZ olin
3-one ( MIT) , Folpet/ 1, 2-BenZ is oth iaZ olin-3-one ( BIT) , Fol
pet/5 -Ch lor o-2-m eth y l-4-is oth iaZ olin-3-one ( CMIT) , Fol
pet/2-Octy l-4-is oth iaZ olin-3-one ( OIT) , Folpet/3-iodo-2
pr opy ny lbuty l-car bam ate ( IPBC) , Folpet/ox y ? uor f en,
Folpet/3-iodopr opy ny l car bam ate ( IPC) , Folpet/3 -iodopr o
py ny l-N -ph eny l car bam ate ( IPPC) , Folpet/th iabendaZ ole,
Folpet/ter butr y n, Folpet/Z inc py r ith ione ( Z nPy ) , Folpet/br o
nopol, Folpet/dir uon, Folpet/ Silv er , Folpet/deh y dr oacetic
acid ( D HA) , Folpet/daZ om et and/or Folpet/car bendaZ im .
Par ticular ly us ef ul biocide com binations include Folpet/
IPBC, Folpet/OIT and Folpet/Th iabendaZ ole ( TBZ ) .
[ 0041] Accor ding to cer tain as pects of th e pr es ent applica
tion, th e W t. r atio of ( i) tr ih alom eth y l-th io-ph th alim ide ( ii) a
s econd biocide m ay be in th e r ang e of about 1: 1 to about 10: 1.
Par ticular ly us ef ul r atios include 1: 1, 2: 1, 3: 1 and/or 4: 1.
[ 0042] Accor ding to one em bodim ent, th e r eq uir ed am ount
of biocide concentr ate com pos ition can be incor por ated in
v ar ious end-us e applications . In par ticular , th e concentr ate
can be us ed to pr otect v ar ious poly m er m atr ices . In accor
dance W ith cer tain em bodim ents , th e biocide concentr ate
com pos ition m ay be incor por ated into a poly m er m atr ix in a
W t, r atio of about 1 to 10 concentr ate to 9 9 to 10 poly m er
m atr ix . For ex am ple, th e poly m er m atr ix m ay be s elected
f r om th e g r oup including , but not lim ited to, poly ole? n, poly
acr y late, poly m eth acr y late, poly v iny l ch lor ide, h alog en-con
taining poly m er , poly ur eth ane, s atur ated or uns atur ated poly
es ter , a poly m er der iv ed f r om uns atur ated alcoh ols and
am ines or f r om th eir acy l der iv ativ es or acetals , a h om o or
copoly m er of cy clic eth er s , poly acetal, poly ph eny lene ox ide
or poly ph eny lene s ul? de, poly am ide or copoly am ide, a ph e
nol-f or m aldeh y de r es in, an epox y r es in or an am inoplas tic
r es in, W ood-plas tic com pos ite, poly car bonate, elas tom er ,
r ubber , acr y lic, ny lon, ? uor ocar bon, a poly s ty r ene alone or
m ix tur es th er eof . Speci? c ex am ples of s elected poly m er ic
m ater ials ar e pr ov ided beloW :
[ 0043] Poly m er s of Monoole? ns and D ioe? ns : Accor ding
to th e pr es ent application, non-lim iting ex am ples of poly m er s
of m onoole? n or diole? n include poly pr opy lene, poly is obu
ty lene, poly but-1-ene, poly -4-m eth y lpent-1-ene, poly is o
pr ene, poly butadiene, cy clopentene, nor bom ene, poly eth y l
ene ( optionally cr os s link ed) , f or ex am ple h ig h dens ity
poly eth y lene ( HD PE) , h ig h dens ity and h ig h m olecular
W eig h t poly eth y lene ( HD PE-HMW ) , h ig h dens ity and ultr a
h ig h m olecular W eig h t poly eth y lene ( HD PE-UHMW ) ,
m edium dens ity poly eth y lene ( MD PE) , loW dens ity poly eth
y lene ( LD PE) , linear loW dens ity poly eth y lene ( LLD PE) ,
( VLD PE) and ( ULD PE) . Als o, m ix tur es of th e abov e m en
tioned poly m er s , f or ex am ple m ix tur es of poly pr opy lene W ith
poly is obuty lene, poly pr opy lene W ith poly eth y lene ( f or
ex am ple PP/HD PE, PP/LD PE) and m ix tur es of dif f er ent
N ov . 21, 2013
ty pes of poly eth y lene s uch as LD PE/HD PE. Oth er ex am ples
include copoly m er s of m onoole? ns and diole? ns am ong
th em s elv es or W ith oth er v iny l m onom er s s uch as eth y lene/
pr opy lene copoly m er s , linear loW dens ity poly eth y lene ( LL
D PE) and m ix tur es th er eof W ith loW dens ity poly eth y lene
( LD PE) , pr opy lene/but-l-ene copoly m er s , pr opy lene/is obu
ty lene copoly m er s , eth y lene/but-l-ene copoly m er s , eth y l
ene/h ex ene copoly m er s , eth y lene/m eth y lpentene copoly
m er s , eth y lene/h eptene copoly m er s , eth y lene/octene
copoly m er s , pr opy lene/butadiene copoly m er s , is obuty lene/
is opr ene copoly m er s , eth y lene/alk y l acr y late copoly m er s ,
eth y lene/alk y l m eth acr y late copoly m er s , eth y lene/v iny l
acetate copoly m er s and of th eir copoly m er s W ith car bon
m onox ide or eth y lene/ acr y lic acid copoly m er s and th eir s alts
( ionom er s ) as W ell as ter poly m er s of eth y lene W ith pr opy lene
and a diene s uch as h ex adiene, dicy clopentadiene or eth
y lidene-nor bom ene; and m ix tur es of s uch copoly m er s W ith
one anoth er and W ith oth er poly m er s , s uch as poly pr opy lene/
eth y lene-pr opy lene copoly m er s , LD PE/eth y lene-v iny l
acetate copoly m er s ( EVA) , LD PE/eth y lene-acr y lic acid
copoly m er s ( EM) , LLD PE/ EVA, LLD PE/EAA and altem at
ing or r andom poly alk y lene/car bon m onox ide copoly m er s
and m ix tur es th er eof W ith oth er poly m er s , f or ex am ple poly a
m ides .
[ 0044] Hy dr ocar bon r es ins : h y dr og enated m odi? cations
th er eof and m ix tur es of poly alk y lenes and s tar ch .
[ 0045 ] ( ii) Poly s ty r enes : ( i) Poly ( p-m eth y ls ty r ene) , poly
( ot-m eth y ls ty r ene) , h ig h -im pact poly s ty r enes , bex tr ene,
poly s ty r ene-poly is opr ene-poly s ty r ene block copoly m er .
( ii) Copoly m er s of s ty r ene or ot-m eth y ls ty r ene W ith dienes
or acr y lic der iv ativ es , f or ex am ple s ty r ene/butadiene, s ty
r ene/acr y lonitr ile, s ty r ene/alk y l m eth acr y late, s ty r ene/
butadiene/alk y l acr y late, s ty r ene/butadiene/alk y l m eth
acr y late, s ty r ene/m aleic anh y dr ide, s ty r ene/acr y lonitr ile/
m eth y l acr y late; m ix tur es of h ig h im pact s tr eng th of
s ty r ene copoly m er s and anoth er poly m er , f or ex am ple a
poly acr y late, a diene poly m er or an eth y lene/pr opy lene/
diene ter poly m er ; and block copoly m er s of s ty r ene s uch as
s ty r ene/butadiene/s ty r ene, s ty r ene/is opr ene/s ty r ene, s ty
r ene/ eth y lene/buty lene/ s ty r ene or s ty r ene/eth y lene/pr opy
lene/s ty r ene. ( iii) Gr af t copoly m er s of s ty r ene or ot-m eth
y ls ty r ene, f or ex am ple s ty r ene on poly butadiene, s ty r ene
on poly butadiene-s ty r ene or poly butadiene-acr y lonitr ile
copoly m er s ; s ty r ene and acr y lonitr ile/m eth acr y lonitr ile on
poly butadiene; s ty r ene, acr y lonitr ile and m eth y l m eth acr y
late on poly butadiene; s ty r ene and m aleic anh y dr ide on
poly butadiene; s ty r ene, acr y lonitr ile and m aleic anh y dr ide
or m aleim ide on poly butadiene; s ty r ene and m aleim ide on
poly butadiene; s ty r ene and alk y l acr y lates or m eth acr y
lates on poly butadiene; s ty r ene and acr y lonitr ile on eth y l
ene/pr opy lene/diene ter poly m er s ; s ty r ene and acr y lonitr ile
on poly alk y l acr y lates or poly alk y l m eth acr y lates , s ty r ene
and acr y lonitr ile on acr y late/butadiene copoly m er s , as
W ell as m ix tur es th er eof W ith th e copoly m er s r ev ealed in
( ii) , f or ex am ple th e copoly m er m ix tur es k noW n as ABS,
MBS, ASA or AES poly m er s .
[ 0046 ] ( iii) Halog en-containing poly m er s : Poly ch lor o
pr ene, ch lor inated r ubber s , ch lor inated and br om inated
copoly m er of is obuty lene-is opr ene ( h alobuty l r ubber ) ,
ch lor inated or s ulf och lor inated poly eth y lene, copoly m er s
of eth y lene and ch lor inated eth y lene, epich lor oh y dr in
h om o and copoly m er s , es pecially poly m er s of h alog en
containing v iny l com pounds , f or ex am ple poly v iny l ch lo
r ide, poly v iny lidene ch lor ide, poly v iny l ? uor ide, poly v i
US 2013/0310428 A1
ny lidene ? uor ide, in addition copoly m er s th er eof s uch as
v iny l ch lor ide/v iny lidene ch lor ide, v iny l ch lor ide/v iny l
acetate or v iny lidene ch lor ide/v iny l acetate copoly m er s .
[ 0047 ] ( iv ) 0t, [ 3-Uns atur ated acid bas ed poly m er s and its
der iv ativ es : ( i) Poly acr y lates and poly m eth acr y lates ; poly
m eth y l m eth acr y lates , poly acr y lam ides and poly acr y loni
tr iles , im pact-m odi? ed W ith buty l acr y late. ( ii) Copoly
m er s of th e m onom er s m entioned under ( i) W ith each oth er
or W ith oth er uns atur ated m onom er s , f or ex am ple acr y loni
tr ile/butadiene copoly m er s , acr y lonitr ile/alk y l acr y late
copoly m er s , acr y lonitr ile/alk ox y alk y l acr y late or acr y loni
tr ile/v iny l h alide copoly m er s or acr y lonitr ile/alk y l m eth
acr y late/butadiene ter poly m er s .
[ 0048] ( v ) Uns atur ated alcoh ols /Am ines /Acy l/Acetals
bas ed poly m er s : Poly v iny l alcoh ol, poly v iny l acetate,
poly v iny l s tear ate, poly v iny l benZ oate, poly v iny l m aleate,
poly v iny l buty r al, poly ally l ph th alate or poly ally l
m elam ine; additionally th eir copoly m er s W ith ole? ns s uch
as poly pr opy lene, poly is obuty lene, poly but-1-ene, poly -4
m eth y lpent-1-ene, poly is opr ene or poly butadiene,
cy cloole? ns , poly eth y lene, f or ex am ple HD PE, HD PE
HMW , HD PE-UHMW , MD PE, LD PE, LLD PE, VLD PE
and ULD PE.
[ 0049 ] ( v i) Cy clic eth er s : Hom opoly m er s and copoly m er s
of cy clic eth er s f or ex am ple poly alk y lene g ly cols , poly eth
y lene ox ide, poly pr opy lene ox ide or copoly m er s th er eof
W ith bis g ly cidy l eth er s .
[ 005 0] ( v ii) Poly acetals : Poly ox y m eth y lene com pr is ing
eth y lene ox ide as a com onom er ; poly acetals m odi? ed W ith
th er m oplas tic poly ur eth anes , acr y lates or m eth acr y late
butadiene-s ty r ene ( MBS) .
[ 005 1] ( v iii) Poly ur eth ane ( PUR) : Poly ur eth anes ar e pr o
duced by th e poly addition r eaction of a poly is ocy anate
W ith a poly alcoh ol ( poly ol) in th e pr es ence of a cataly s t and
oth er additiv es . It is der iv ed pr ef er ably f r om h y dr ox y l
ter m inated poly eth er s , poly es ter s or poly butadienes on th e
one h and and aliph atic or ar om atic poly is ocy anates on th e
oth er , as W ell as pr ecur s or s th er eof .
[ 005 2] ( ix ) Poly am ides and copoly am ides : Th es e poly m er s
ar e der iv ed f r om diam ines and dicar box y lic acids and/or
f r om am inocar box y lic acids or th e cor r es ponding lactam s ,
s uch as poly am ide 4, poly am ide 6 , poly am ide 6 /6 , 6 / 10,
6 /9 , 6 /12, 416 , 12/12, poly am ide 11, poly am ide 12, ar o
m atic poly am ides s tar ting f r om m -x y lene diam ine and adi
pic acid; poly am ides pr epar ed f r om h ex am eth y lenedi
am ine and is oph th alic or /and ter eph th alic acid and W ith or
W ith out an elas tom er as m odi? er , f or ex am ple poly -2, 4, 4,
tr im eth y lh ex am eth y lene ter eph th alam ide or poly -m -ph e
ny lene is oph th alam ide; and als o block copoly m er s of th e
af or em entioned poly am ides W ith poly ole? ns , ole? n
copoly m er s , ionom er s or ch em ically bonded or g r af ted
elas tom er s ; or W ith poly eth er s , eg w ith poly eth y lene g ly
col, poly pr opy lene g ly col or poly tetr am eth y lene g ly col; as
W ell as poly am ides or copoly am ides m odi? ed W ith ( Eth
y lene pr opy lene diene m onom er ) EPD M or acr y lonitr ile
butadiene- s ty r ene ( ABS) ; and poly am ides condens ed dur
ing pr oces s ing .
[ 005 3] ( x ) Poly es ter s : ( i) Poly es ter s der iv ed f r om dicar
box y lic acids and dials and/or f r om h y dr ox y car box y lic
acids or th e cor r es ponding lactones , f or ex am ple poly eth
y lene ter eph th alate, poly buty lene ter eph th alate, poly -1, 4
dim eth y lolcy cloh ex ane ter eph th alate and poly h y dr ox y
benZ oates , as W ell as block copoly eth er es ter s der iv ed f r om
h y dr ox y l-ter m inated poly eth er s ; and als o poly es ter s m odi
N ov . 21, 2013
? ed W ith poly car bonates or MBS. ( ii) Uns atur ated poly es
ter s th os e ar e der iv ed f r om anh y dr ides or acids of ar om atic,
s atur ated and uns atur ated aliph atic dicar box y lic acids and
f r om ar om atic, s atur ated and uns atur ated aliph atic diols
s uch as f um ar ic acid, m aleic acid, m aleic anh y dr ide,
ph th alic anh y dr ide, is oph th alic anh y dr ide, ter eph th alic
acid, adipic acid, eth y lene g ly col, pr opanediol, butanediol,
neopenty l g ly col, bis ph enol A, bis ph enol F, butenediol,
etc. Cur ing of th e uns atur ated poly es ter s is car r ied out
r adically in a cr os s link ing copoly m er iZ ation W ith v iny l
m onom er s s uch as s ty r ene, p-m eth y ls ty r ene, ot-m eth y ls ty
r ene, m eth y l m eth acr y late, acr y lic acid, m eth y l acr y late,
acr y lonitr ile, and m ix tur es of th es e m onom er s .
[ 005 4] ( x i) N atur al poly m er s : Cellulos e, r ubber , g elatin
and ch em ically m odi? ed h om olog ous der iv ativ es th er eof ,
f or ex am ple cellulos e acetates , cellulos e pr opionates and
cellulos e buty r ates , or th e cellulos e eth er s s uch as m eth y l
cellulos e; as W ell as r es ins and th eir der iv ativ es .
[ 005 5 ] ( x ii) Poly m er blends : Blends of th e af or em entioned
poly m er s s uch as PP/EPD M, Poly am ide/EPD M or ABS,
PVC/EVA, PVC/ABS, PVC/MBS, PC/ABS, PBTP/ABS,
PC/ASA, PC/PBT, PVC/CPE, PVC/acr y lates , POM/th er
m oplas tic PUR, PC/th er r noplas tic PUR, POM/acr y late,
POM/MBS, PPO/HIPS, PPO/PA 6 . 6 and copoly m er s ,
PAN HD PE, PA/PP, PA/PPO, PBT/PC/ABS or PBT/PET/
PC.
[ 005 6 ] ( x iii) Oth er Poly m er s : ( i) Poly ph eny lene ox ides and
s ul? des , and m ix tur es of poly ph eny lene ox ides W ith s ty
r ene poly m er s or poly am ides ; ( ii) Poly car bonates and
poly es ter car bonates ; ( iii) Cr os s link ed poly m er s der iv ed
f r om aldeh y des on th e one h and and f r om ph enols , ur eas or
m elam ines on th e oth er h and, s uch as ph enol-f or m alde
h y de, ur ea-f or m aldeh y de and m elam ine-f or m aldeh y de
r es ins ; and ( iv ) Epox y r es ins ar e der iv ed f r om di and poly
f unctional epox ides W h ich ar e cr os s link ed W ith
poly am ines , f or ex am ple dieth y lenetr iam ine, tr ieth y lene
tetr am ine, tetr aeth y lenepentam ine, m eth y lenedianiline,
diam inodiph eny ls ulf one and poly am inoam ides or W ith
dicar box y lic acids and th eir anh y dr ides , lik e h ex ah y dr o
ph th alic anh y dr ide, ph th alic anh y dr ide, py r om ellitic anh y
dr ide, m eth y lnadic anh y dr ide.
[ 005 7 ] Accor ding to th e s om e as pects of th e pr es ent appli
cation, an antiox idant ag ent m ay be included as par t of th e
biocide concentr ate com pos ition. Th e antiox idant containing
biocide com pos ition is em ploy ed in th e pr epar ation of any of
th e abov e lis ted indus tr ial poly m er ic m atr ices to af f or d anti
m icr obicidal ef f ects , and th e pr es ence of th e antiox idant
ag ent m ay alloW th e biocide to W ith s tand h ig h pr oces s ing
tem per atur es of about 2800 C. as W ell as pr ev ent th e dis col
or ation of th e poly m er m atr ix . Th e s uitable antiox idants f or
th e pr es ent biocide concentr ate com pos ition W ould include
but ar e not lim ited to th e f olloW ing lis t of antiox idant ag ents :
[ 005 8] ( i) Alk y lated m onoph enols : 2, 6 -di-tent-buty l-4-m e
th y lph enol, 2-tent-buty l-4, 6 -di-m eth y lph enol, 2, 6 -di-tent
buty l-4-eth y lph enol, 2, 6 -di-tent-buty l-4-n-buty lph enol,
2, 6 -di-ter t-buty l-4-is obuty lph enol, 2, 6 -dicy clopenty l-4
m eth y lph enol, 2-( 0t-m eth y lcy cloh ex y l) 4, 6 -dim eth y lph e
nol, 2, 6 -dioctadecy l-4-m eth y lph enol, 2, 4, 6 -tr icy cloh ex y
lph enol, 2, 6 -di-ter t-buty l-4-m eth ox y m eth y lph enol,
nony lph enols W h ich ar e linear or br anch ed in th e s ide
ch ains , s uch as 2, 6 -di-nony l-4-m eth y lph enol, 2, 4-dim
eth y l-6 -( 1' -m eth y lundec-1' -y l) ph enol, 2, 4-dim eth y l-6 -( 1'
m eth y lh eptadec- 1 ' -y l) ph enol, 2, 4-dim eth y l-6 -( 1 ' -m eth y l
tr idec-1' -y l) ph enol and m ix tur es th er eof ;
US 2013/0310428 A1
ter t-buty l-4-h y dr ox y ph eny l) pr opionic acid eg N , N ' -bis
( 3, 5 -di-ter t-buty l-4-h y dr ox y ph eny lpr opiony l)
h ex am eth y lenediam ide, N , N ' -bis ( 3, 5 -di-ter t-buty l-4
h y dr ox y ph eny lpr opiony l) tr im eth y lenediam ide, N , N ' -bis
( 3 , 5 -d i-ter t-buty l-4-h y dr ox y ph eny lpr opiony l) -h y dr aZ ide,
N , N ' -bis [ 2-( 3, 5 -di-ter t-buty l-4-h y dr ox y ph eny l]pr opiony
lox y ) eth y l]ox am ide ( N aug ar d X L-1 s upplied by
Unir oy al) ; ( x iv ) As cor bic acid ( v itam in C) ;
[ 007 1] ( x iv ) Am inic antiox idants : N , N ' -di-is opr opy l-p
ph eny lenediam ine, N , N ' -di-s ec-buty l-p-ph eny lenedi
am ine, N , N ' -bis ( 1 , 4-dim eth y lpenty l) -p -ph eny lenedi
am ine, N , N ' -bis ( 1-eth y l-3-m eth y lpenty l) -p
ph eny lenediam ine, N , N ' -bis ( 1-m eth y lh epty l) -p
ph eny lenediam ine, N , N ' -dicy cloh ex y l-p
ph eny lenediam ine, N , N ' -diph eny l-p-ph eny lenediam ine,
N , N ' -bis ( 2-naph th y l) -p -ph eny lenediam ine, N -is opr opy l
N ' -ph eny l-p -ph eny lenediam ine, N -( l , 3 -dim eth y lbuty l)
N ' -ph eny l-p -ph eny lenediam ine, N -( 1 -m eth y lh epty l) -N '
ph eny l-p-ph eny lenediam ine, N -cy cloh ex y l-N ' -ph eny l-p
ph eny lenediam ine, 4-( p-toluenes ulf am oy l)
diph eny lam ine, N , N ' -dim eth y l-N , N ' -di-s ec -buty l-p
ph eny lenediam ine, diph eny lam ine,
N -ally idiph eny lam ine, 4-is opr opox y diph eny lam ine,
N -ph eny l- 1 -naph th y lam ine, N -( 4-ter t-octy lph eny l) -1 -
naph th y lam ine, N -ph eny l-2-naph th y lam ine, octy lated
diph eny lam ine, s uch as p, p' -di-ter t-octy ldiph eny lam ine,
4-n-buty lam inoph enol, 4-buty r y lam inoph enol,
4-nonanoy lam inoph enol, 4-dodecanoy lam inoph enol,
4-octadecanoy lam inoph enol, bis ( 4-m eth ox y ph eny l)
am ine, 2, 6 -di-ter t-buty l-4-dim eth y lam inom eth y lph enol,
2, 4' -diam inodiph eny lm eth ane, 4, 4' -diam inodiph eny l
m eth ane, N , N , N , N ' -tetr am eth y l-4, 4' -diam inodiph eny l
m eth ane, 1, 2-bis [ ( 2-m eth y lph eny l) am ino]eth ane, 1, 2-bis
( ph eny lam ino) pr opane, ( o-toly l) big uanide, bis [ 4-( 1' , 3'
dim eth y lbuty l) ph eny l]am ine, ter t-octy lated N -ph eny l-l
naph th y lam ine, a m ix tur e of m ono and dialk y lated ter t
buty l/ter t-octy ldiph eny lam ines , a m ix tur e of m ono and
dialk y lated nony ldiph eny lam ines , a m ix tur e of m ono and
dialk y lated dodecy ldiph eny lam ines , a m ix tur e of m ono
and dialk y lated is opr opy l/is oh ex y ldiph eny lam ines , a m ix
tur e of m ono- and dialk y lated ter t-buty ldiph eny lam ines ,
2, 3-dih y dr o -3, 3-dim eth y l-4H-1, 4-benZ oth iaZ ine, ph e
noth iaZ ine, a m ix tur e of m ono and dialk y lated ter t-buty l/
ter t-octy lph enoth iaZ ines , a m ix tur e of m ono and dialk y
lated ter t-octy l-ph enoth iaZ ines , N -ally lph enoth iaZ ine,
N , N , N , N ' -tetr aph eny l-1, 4-diam inobut-2-ene, N , N -bis ( 2,
2, 6 , 6 -tetr a-m eth y l-piper id-4-y l-h ex am eth y lenediam ine,
bis ( 2, 2, 6 , 6 -tetr am eth y lpiper id-4-y l) s ebacate, 2, 2, 6 , 6 -tet
r am eth y lpiper idin-4-one, 2, 2, 6 , 6 -tetr am eth y lpiper idin-4
01.
[ 007 2] Par ticular ly us ef ul antiox idants include tetr abis m
eth y lene-( 3, 5 -di-t-buty l-4-h y dr ox y h y dr ocinnam ate) m eth
ane, octadecy l-3 ( 3, 5 -di-t-buty ! -4 -h y dr ox y ph eny l) -pr opi -
onate, C 1 3-C 1 5 linear and br anch ed alk y l es ter s of 3-pr opionic
acid, 2, 2-th ioeth y lene bis pr opionate, 1, 3, 5 -tr is is ocy anur ate,
1, 3, 5 -tr im eth y i-2, 4, 6 -tr is -benZ ene, 2, 2-m eth y lenebis ph enol,
4, 4-buty lidenebis ph enol, 2, 2-is obuty lidenebis ph enol, 2, 5
di-t-am y lh y dr oq uinone, 0t, 0t3-tr is butane, 1, 3, 5 -tr is -1, 3, 5
tr iaZ one-2, 4, 6 -tr ione, poly m er ic s ter ically h inder ed ph enol,
tr ieth y lene g ly col bis pr opionate, n, n-h ex am eth y lene bis pr o
pionam ide, 4, 4-th iobis ph enol, 2, 2-m eth y lenebis ph enol, 1, 2
bis h y dr aZ ine or tr is ph os ph ate bis pentaer y th r itoi diph os
ph ate alone or in com bination. HoW ev er , th e m os t pr ef er r ed
antiox idant f or th e pr es ent application is s elected f r om th e
N ov . 21, 2013
g r oup cons is ting of but ar e not lim ited to 1, 3, 5 -tr is ( 3, 5 -di-t
buty l-4-h y dr ox y benZ y l) is ocy anur ate, 1, 3, 5 -tr im eth y l-2, 4, 6
tr is -( 3, 5 -d i-ter t-buty l-4-h y dr ox y benZ y l) benZ ene, 2, 2, m eth
y lenebis ( 6 -t-buty l -4-m eth y l ph enol) , 4, 4 buty lidenebis ( 2-t
buty l-5 -m eth y lph enol) , 2, 5 -di-t-am y lh y dr oq uinone, 1, 1, 3
tr is ( 2' m eth y l-4' -h y dr ox y -5 ' -t-buty lph eny l) butane, 1, 3, 5 tr is
( 4 -ter t-buty l-3-h y dr ox y -2-6 -dim eth y lbenZ y l) 1 , 3 , 5 tr iaZ ine
2, 4, 6 -( 1H, 3H, 5 H) -tr ione, 4, 4' -th iobis ( 2-t-buty l-5
m eth y lph enol) octadecy l-3 ( 3' , 5 ' -di-ter t-buty l-4
h y dr ox y ph eny l) pr opionate ( PP-18) and/or tr is -( 2, 4-di
ter tbuty l ph eny l) ph os ph ate ( Alk anox 240) . Fur th er , th e lev el
of antiox idant us ed in th e pr es ent biocide concentr ate com
pos ition dif f er s W ith r es pect to th e k ind of poly m er W h er ein it
is em ploy ed. HoW ev er , in accor dance W ith cer tain as pects th e
W t. r atio of biocide to antiox idant m ay be in th e r ang e of about
1 10. 5 to 1 : 3, W h er ein th e am ount of biocide W ould include th e
com bination of th e ? r s t and s econd biocides .
[ 007 3] In accor dance W ith one em bodim ent, a car r ier f or
th e pr es ent concentr ated com pos ition is pr ov ided. Th e car r ier
m ay be s elected f r om th e g r oup including , but not lim ited to,
plas tic, W ax and/ or plas ticiZ er and W h er ein th e s elected car
r ier can be liq uid or s olid in natur e.
[ 007 4] Th e plas ticiZ er s W h ich can be us ed m us t be com pat
ible W ith th e poly m er com pos ition W ith W h ich th ey ar e to be
m ix ed. Th is can be ach iev ed by th e s election of k noW n plas
ticiZ er s f or th e poly m er W h ich is to be pr otected f r om m icr o
biocidal attack . An adeq uate am ount of th e plas ticiZ er m ay be
em ploy ed to act as a car r ier m ater ial f or th e m icr obiocide. Th e
ex act am ount of plas ticiz er r eq uir ed W ill depend upon th e
ty pe and concentr ation of th e m icr obiocide as W ell as th e
ty pes and am ounts of oth er additiv es W h ich m ay be pr es ent in
th e concentr ate. Us ually , an ex ces s of th e m inim um am ount
of plas ticiZ er W ill be em ploy ed in th e concentr ate in or der to
ens ur e th at th e tox icity lev el r em ains loW . Th e m os t W idely
us ed plas ticiZ er s ar e ph th alates and es ter s of poly car box y lic
acids W ith linear or br anch ed aliph atic alcoh ols of m oder ate
ch ain leng th . Plas ticiZ er s W or k by em bedding th em s elv es
betW een th e ch ains of poly m er s and s pacing th em apar t and
th er eby incr eas ing th e f r ee v olum e , and th us s ig ni? cantly
loW er ing th e g las s tr ans ition tem per atur e f or th e plas tic and
m ak ing it s of ter . Suitable plas ticiZ er s f or th e pur pos es of th e
pr es ent application W ould include, but ar e not lim ited to,
Bis ( 2-eth y lh ex y l) ph th alate ( D EHP) , D iis onony l ph th alate
( D IN P) , Bis ( n-buty l) ph th alate ( D nBP, D BP) , Buty l benZ y l
ph th alate ( BBZ P) , D iis odecy l ph th alate ( D ID P) , D i-n-octy l
ph th alate ( D OP or D nOP) , D iis oocty l ph th alate ( D IOP) ,
D ieth y l ph th alate ( D EP) , D iis obuty l ph th alate ( D IBP) , D i-n
h ex y l ph th alate, Tr im eth y l tr im ellitate ( TMTM) , Tr i-( 2-eth
y lh ex y l) tr im ellitate ( TEHTM-MG) , Tr i-( n-octy l, n-decy l) tr i
m ellitate ( ATM) , Tr i-( h epty l, nony l) tr im ellitate ( LTM) ,
n-octy l tr im ellitate ( OTM) , Bis ( 2-eth y lh ex y l) adipate
( D EHA) , D im eth y l adipate ( D MAD ) , Monom eth y l adipate
( MMAD ) , D iocty l adipate ( D OA) , Sebacate-bas ed plas ti
ciZ er , D ibuty l s ebacate ( D BS) , D ibuty l m aleate ( D BM) ,
D iis obuty l m aleate ( D IBM) , BenZ oates , Epox idiZ ed v eg
etable oils , N -eth y l toluene s ulf onam ide, N -( 2-h y dr ox y pr o
py l) benZ ene s ulf onam ide ( HP BSA) , N -( n-buty l) benZ ene
s ulf onam ide ( BBSA-N BBS) , Tr icr es y l ph os ph ate ( TCP) ,
Tr ibuty l ph os ph ate ( TBP) , Tr ieth y lene g ly col dih ex anoate
( 3G6 , 3GH) , Tetr aeth y lene g ly col dih eptanoate ( 4G7 ) , Poly
m er ic plas ticiZ er s , Poly butene, Acety lated m onog ly cer ides ,
Alk y l citr ates , Tr ieth y l citr ate ( TEC) , Acety l tr ieth y l citr ate
( ATEC) , Tr ibuty l citr ate ( TBC) , Acety l tr ibuty l citr ate
( ATBC) , Tr iocty l citr ate ( TOC) , Acety l tr iocty l citr ate
US 2013/0310428 A1
( ATOC) , Tr ih ex y l citr ate ( THC) , Acety l tr ih ex y l citr ate
( ATHC) , Buty r y l tr ih ex y l citr ate ( BTHC) , Tr im eth y l citr ate
( TMC) or Aalk y l s ulph onic acid ph eny l es ter ( ASE) , C 16 -C22
f atty alcoh ols , CS-C22 f atty acids , s tear ic acid, 1 -h ex adecanol,
1-octadecanol, 1-tetr adecanol, ch lor inated par a? inic h y dr o
car bons and poly eth y lene g ly cols alone or in com bination.
[ 007 5 ] In accor dance W ith one em bodim ent, ph th alate-f r ee
plas ticiz er s ar e em ploy ed to pr epar e th e poly m er com pos i
tion. Th e ph th alate-f r ee plas ticiZ er s f or th e pr es ent applica
tion m ay be s elected f r om th e g r oup including , but not lim ited
to, eth er -es ter com pounds , g ly cer in tr ies ter s , g ly cer y l-1, 2
bis butanoate-benZ oate, g ly cer y l- 1 , 3 -bis butanoate-benZ oate,
g ly cer y l-1, 2-bis benZ oate-butanoate, g ly cer y l-1, 3 -bis ben
Z oate-butanoate, is ocy anur ates , es ter s of an anh y dr os ug ar
alcoh ol, ar y l ph os ph ates , ph enol alk anes ulph onates , dipr opy
lene g ly col dibenZ oate, di( is ony l) cy cloh ex ane dicar box y late,
diis ony l adipate, CS-Cl 8 alk y l py r r olidones , epoX idiZ ed s oy a
bean oil, epoX idiZ ed lins eed oil alone or in com bination.
[ 007 6 ] In a par ticular ly us ef ul em bodim ent, th er e is pr o
v ided a biocide concentr ate com pos ition of a f olpet analog ue
and a s econd biocide, W h ich is capable of inh ibiting or k illing
g r ain ( + ) /g r am ( ) bacter ial s tr ains or f ung al s tr ains in a
s y ner g is tic m anner W ith a loW er concentr ation of s elected
biocidal activ es . Th e s peci? c g r am ( + ) and g r am ( ) bacter ial
s tr ains include, but ar e not lim ited to th e f olloW ing lis t of
g enus Actinobacter ia, Actinom y ces , Bacillales , Bacillus ,
Clos tr idium , Cor y nebacter ium , Enter ococcus , Lactobacilla
les , Lis ter ia, N ocar dia, Pr opionibacter ium , Rh odococcus
eq ui, Sar cina, Solobacter ium , Staph y lococcus , Str eptococ
cus , Acetic acid bacter ia, Acinetobacter , Bacter oides , Bdell
ov ibr io, Cox iella, Cy anobacter ia, Cy toph ag a, Enter obacter ,
Enter obacter iaceae, Es ch er ich ia, Fus obacter ium , Haem o
ph ilus , Helicobacter , Klebs iella, Leg ionella, Leptotr ich ia,
Mor ax ella, N eis s er ia, Pr oteobacter ia, Pr oteus , Ps eudom o
nas , Rick etts ia, Salm onella, Ser r atia, Sh ig ella, Spir och aete,
Stenotr oph om onas , ly ph us , Vam pir ococcus , Ver m ineph r o
bacter , W br io, W olbach ia. Th e pr ef er r ed bacter ial g enus ar e
Actinobacter ia, Staph y lococcus , Es ch er ich ia, Salm onella,
Sh ig ella, Enter obacter iaceae, Ps eudom onas , Mor ax ella,
Helicobacter , and/or Leg ionella. Fur th er , th e ex am ples of
f ung i to W h ich , th e com pos itions of th e pr es ent application
ar e applicable include but ar e not lim ited to: Alter nar ia alter
nata, As per g illus ? av us , As per g illus ter r eus , As per g illus
f um ig atus , As per g illus r epens , As per g illus v er s icolor , Can
dida albicans , Ch aetom ium g lobos um , Clados por ium cla
dos por ioides , Clados por ium h er bar um , Clados por ium
s ph aer os per m um , Conioph or a puteana, Cur v ular ia g enticu
lata, D iplodia natalens is , Epider m oph y ton? occos um ,
Fus ar ium ox y s por um , Gliocladium v ir ens , Gloeoph y llum
tr abeum , Hum icola g r is ea, Lecy th oph or a m utabilis , Lentinus
cy aih if or m is , Lentinus lepidus , Mem nionella ech inata,
Mucor indicus , Mucor r acem os us , Olig opor us placenta,
Paecilom y ces Penicillium citr im un, Penicillium f uniculos um ,
Penicillium och r och lor on, Penicillium pur pur og enum , Peni
cillium pinoph ilum , Penicillium v ar iabile, Petr iella s eti er a,
Ph aner och aete ch r y s os por ium , Ph om a v iolacea, Por ia pla
centa, Rh odotor ula r ubr a, Sch iz oph y llum com m une, Scler o
ph om a ph y tioph ila Scopular iops is br ev icaulis , Ser pula laay
m ans , Spor obolom y ces r os eus , Stem ph y liw n dendr iticum ,
T r ich oph y ton m entag r oph y tes , lich ur us T r ich oph y ton
r ubr uni, Ulocladium altr um and Ulocladium ch ar tar um . Of
W h ich par ticular ly inter es ted f ung al s tr ains ar e Alter nar ia
alter nata, Alter nar ia tenuis s im a, As per g illus nig er , As per g il
lus v er s icolor , Aur eobas idium pullulans , Ch aetom ium g lobo
N ov . 21, 2013
s um , Clados por ium clados por ioides , Conioph or a puteanct,
Gloeoph y llum tr abeum , Mem nionella ech inata, Mucor indi
cus , Olig opor us placenta, Penicillium citr im um , Penicillium
ch r y s og enum , Penicillium f uniculos um , Penicillium pinoph i
lum , Scler oph om a ph y tioph ila, Stach y botr y s atr a, Stach y bot
r y s ch ar tar um , and Ulocladium ch ar tar um . Th e m os t pr e
f er r ed bacter ial and f ung al s tr ains th at can be inh ibited or
k illed by th e pr es ent biocide com pos ition ar e Staph y lococcus
aur eus , Klebs iella pneum onia, Ps eudom onas ar eug inos a,
Bacillus s ubtilus , As per g illus nig er , As per g illus ? av us , Os cil
lator ia tenius , Penicillin f uniculos um , Ch aetom ium g lobo
s um , Aur eobas idium pullulans , Tr ich oder m a v ir ens and/or
Str eptov er ticillium r eticulum .
[ 007 7 ] An ultr av iolet lig h t abs or ber is optionally em ploy ed
in th e pr es ent biocide concentr ate com pos ition. Ex am ples of
ultr av iolet lig h t abs or ber s include, but ar e not lim ited to, one
or m or e of th e f olloW ing m ater ials 2-( 2' -Hy dr ox y ph eny l) ben
Z otr iaZ oles : 2-( 2' -h y dr oX y -5 ' -m eth y lph eny l) benZ otr iaZ ole,
2-( 3' , 5 ' -di-ter t-buty l-2' -h y dr ox y ph eny l) benZ otr iaZ ole, 2-( 5 '
ter t-buty l-2' -h y dr ox y ph eny l) benZ otr iaZ ole, 2-( 2' -h y dr ox y
5 ' -( 1, 1, 3, 3-tetr am eth y lbuty l) ph eny l) benZ otr iaZ ole, 2-( 3' , 5 '
di-ter t-buty l-2' -h y dr oX y ph eny l) -5 -ch lor obenZ otr iaZ ole,
2-( 3' -ter t-buty l-2' -h y dr oX y -5 ' -m eth y lph eny l) -5 -ch lor o-ben
Z otr iaZ ole, 2-( 3' -s ec-buty l-5 ' -ter t-buty l-2' -h y dr ox y -ph eny l)
benZ otr iaZ ole, 2-( 2' -h y dr ox y 4' -octy loX y ph eny l) benZ otr iaZ
ole, 2-( 3' , 5 ' -di-ter t-am y l-2' -h y dr ox y ph eny l) benZ otr iaZ ole,
2-( 3' , 5 ' -bis ( 0t, 0t-dim eth y lbenZ y l) -2' -h y dr oX y ph eny l) benZ ot
r iaZ ole, 2-( 3' -ter t-buty l-2' -h y dr ox y -5 ' -( 2-octy lox y car bony l
eth y l) ph eny l) -5 -ch lor obenZ otr iaZ ole, 2-( 3' ter t-buty l-5 ' -[ 2
( 2 -eth y lh ex y lox y ) car bony l eth y l] -2' -h y dr ox y ph eny l) -5 -
ch lor obenZ otr iaZ ole, 2-( 3' -ter t-buty l-2' -h y dr oX y -5 ' -( 2
m eth ox y car bony leth y l) ph eny l) -5 -ch lor obenZ otr iaZ ole,
2-( 3' -ter t-buty l-2' -h y dr oX y -5 ' -( 2-m eth ox y car bony leth y l)
ph eny l) benZ otr iaZ ole, 2-( 3' ter t-buty l-2' -h y dr ox y -5 ' -( 2-octy
lox y car bony leth y l) ph eny l) benZ otr iaZ ole, 2-( 3' -ter t-buty l-5 '
[ 2-( 2 -eth y lh ex y lox y ) car bony leth y l] -2' -h y dr ox y ph eny l)
benZ otr iaZ ole, 2-( 3' -dodecy l-2' -h y dr ox y -5 ' -m eth y lph eny l)
benZ otr iaZ ole, 2-( 3' -ter t-buty l-2' -h y dr oX y -5 ' -( 2
is oocty lox y car bony leth y l) ph eny lbenZ otr iaZ ole, 2, 2
m eth y lenebis [ 4-( 1 , 1 , 3, 3-tetr am eth y lbuty l) -6 -benZ otr iaZ ole
2-y lph enol]; th e tr ans -es ter i? cation pr oduct of 2-[ 3' -ter t
buty l-5 ' -( 2-m eth ox y car bony leth y l) -2' -h y dr ox y ph eny l]-2H
benZ otr iaZ ole W ith poly eth y lene g ly col 300; [ Rf
CH2CH2CH24COO4CH2ik , W h er e R: 3' -ter t
buty l-4' -h y dr ox y -5 ' -2H-benZ otr iaZ ol-2-y lph eny l, 2-[ 2'
h y dr oX y -3' -( 0t, 0t-dim eth y lbenZ y l) -5 ' -( 1, 1, 3, 3
tetr am eth y lbuty l) ph eny l]-benZ otr iaZ ole; 2-[ 2' -h y dr oX y -3'
( 1 , 1 , 3, 3-tetr am eth y lbuty l) -5 ' -( 0t, ot-dim eth y lbenz y l) ph eny l]
benZ otr iaZ ole; 2-Hy dr ox benZ oph enones : 4-h y dr ox y ,
4-m eth ox y , 4-octy lox y , 4-decy lox y , 4-dodecy lox y , 4-benZ y
lox y , 4, 2' , 4' -tr ih y dr ox y and 2' -h y dr ox y -4, 4' -dim eth ox y
der iv ativ es ; Es ter s of s ubs tituted and uns ubs tituted benZ oic
acids : 4-ter tbuty l-ph eny l s alicy late, ph eny l s alicy late,
octy lph eny l s alicy late, dibenZ oy l r es or cinol, bis ( 4-ter t-buty l
benZ oy l) r es or cinol, benZ oy l r es or cinol, 2, 4-di-ter t-buty lph e
ny l 3, 5 -di-ter t-buty l-4-h y dr oX y benZ oate, h ex adecy l 3, 5 -di
ter t-buty l-4-h y dr oX y benZ oate, octadecy l 3, 5 -di-ter t-buty l-4
h y dr oX y benZ oate, 2-m eth y l-4, 6 -di-ter t-buty lph eny l 3, 5 -di
ter t-buty l-4-h y dr oX y benZ oate; Acr y lates : eth y l-ot-cy ano-B,
[ 3-diph eny lacr y late, is oocty l-ot-cy ano-[ 3-diph eny lacr y late,
m eth y l ot-car bom eth ox y cinnam ate, m eth y l-ot-cy ano-[ 3-m e
th y l-p-m eth ox y cinnam ate, buty l-ot-cy ano-[ 3-m eth y l-p-m eth
ox y cinnam ate, m eth y l-0t-car bom eth ox y -p-m eth ox y cin
nam ate and N -( B-car bom eth oX y -B-cy anov iny l) -2
US 2013/0310428 A1
m eth y lindoline; N ick el com pounds : nick el com plex es of
2, 2' -th iobis [ 4-( 1, 1, 3, 3-tetr am eth y lbuty l) ph enol], s uch as th e
1: 1 or 1: 2 com plex , W ith or W ith out additional lig ands s uch as
n-buty lam ine, tr ieth anolam ine or N -cy cloh ex y ldieth anola
m ine, nick el dibuty ldith iocar bam ate, nick el s alts of th e
m onoalk y l es ter s , e. g . th e m eth y l or eth y l es ter , of 4-h y dr ox y
3, 5 -di-ter t-buty lbenZ y lph os ph onic acid, nick el com plex es of
k etox im es , eg of 2-h y dr ox y -4-m eth y lph eny l undecy lk e
tox im e, nick el com plex es of 1-ph eny l-4-laur oy l-5 -h y dr ox y
py r aZ ole, W ith or W ith out additional lig ands ; Ster ically h in
der ed am ines : bis ( 2, 2, 6 , 6 -tetr am eth y l-4-piper idy l) s ebacate,
bis ( 2, 2, 6 , 6 -tetr am eth y l-4-piper idy l) s uccinate, bis ( 1, 2, 2, 6 , 6
pentam eth y l-4-piper idy pl) s ebacate, bis ( 1-octy lox y -2, 2, 6 , 6
tetr am eth y l-4-piper idy l) s ebacate, bis ( 1 , 2, 2, 6 , 6 -pentam
eth y l-4-piper idy l) n-buty l-3, 5 -di-ter t-buty l-4
h y dr ox y benZ y lm alonate, th e condens ate of 1-( 2
h y dr ox y eth y l) -2, 2, 6 , 6 -tetr am eth y l-4-h y dr ox y piper idine and
s uccinic acid, linear or cy clic condens ates of N , N ' -bis ( 2, 2, 6 ,
6 -tetr am eth y l-4 -piper idy l) h ex am eth y lenediam ine and 4-ter t
octy lam ino-2, 6 -di-ch lor o-1, 3, 5 -tr iaZ ine, tr is ( 2, 2, 6 , 6 -tetr am
eth y l-4-piper idy l) nitr ilotr iacetate, tetr ak is ( 2, 2, 6 , 6
tetr am eth y l-4 -pip er idy l) -1 , 2 , 3 , 4 -butanetetr acar box y l ate,
1, 1' -( 1 , 2-eth anediy l) -bis -( 3 , 3 , 5 , 5 -tetr am eth y lpiper aZ inone) ,
4-benZ oy l-2, 2, 6 , 6 -tetr am eth y lpiper idine, 4-s tear y lox y -2, 2, 6 ,
6 -tetr am eth y lpiper idine, bis ( 1 , 2, 2, 6 , 6 -pentam eth y lpip
er idy l) -2-n-buty l-2-( 2-h y dr ox y -3, 5 -di-ter t-buty lbenZ y l) -m a
lonate, 3-n-octy l-7 , 7 , 9 , 9 -tetr am eth y l-1, 3, 8-tr iaZ as pir o-[ 4, 5 ]
decane-2, 4-dione, bis ( 1-octy lox y -2, 2, 6 , 6
tetr am eth y lpiper idy l) s ebacate, bis ( 1-octy lox y -2, 2, 6 , 6
tetr am eth y lpiper idy l) s uccinate, linear or cy clic condens ates
of N , N ' -bis ( 2, 2, 6 , 6 -tetr am eth y l-4-piper idy l) h ex am eth y lene
diam ine and 4-m or ph olino-2, 6 -dich lor o-1, 3, 5 -tr iaZ ine, th e
condens ate of 2-ch lor o-4, 6 -bis ( 4-n-buty lam ino-2, 2, 6 , 6 -tet
r am eth y lpiper idy l) -1, 3, 5 -tr iaZ ine and 1, 2-bis ( 3 -am inopr opy
lam ino) -eth ane, th e condens ate of 2-ch lor o-4, 6 -di( 4-n-buty
lam ino-1 , 2, 2, 6 , 6 -pentam eth y lpiper idy l) - 1 , 3 , 5 -tr iaZ ine and
1, 2-bis ( 3-am inopr opy lam ino) eth ane, 8-acety l-3-dodecy l-7 ,
7 , 9 , 9 -tetr am eth y l-1, 3, 8-tr iaZ as pir o[ 4, 5 ]decane-2, 4-dione,
3 -dodecy l-1-( 2, 2, 6 , 6 -tetr am eth y l-4-piper idy l) py r r olidin-2,
5 -dione, 3-dodecy l-1-( 1, 2, 2, 6 , 6 -pentam eth y l-4-piper idy l)
py r r olidine-2, 5 -dione, a m ix tur e of 4-h ex adecy lox y - and
4-s tear y lox y -2, 2, 6 , 6 -tetr am eth y lpiper idine, a condens ation
pr oduct of N , N ' -bis ( 2, 2, 6 , 6 -tetr am eth y l-4-piper idy l) h ex am
eth y lenediam ine and 4-cy cloh ex y lam ino-2, 6 -dich lor o-1, 3, 5
tr iaZ ine, a condens ation pr oduct of 1, 2-bis ( 3-am inopr opy
lam ino) eth ane and 2, 4, 6 -tr ich lor o-1, 3, 5 -tr iaZ ine as W ell as
4-buty lam ino-2, 2, 6 , 6 -tetr am eth y lpiper idine ( CAS Reg . N o.
[ 136 5 04-9 6 -6 ]) ; N -( 2, 2, 6 , 6 -tetr am eth y l-4-piper idy l) -n
dodecy ls uccinim ide, N -( l , 2, 2, 6 , 6 -pentam eth y l-4-piper idy l)
n-dodecy ls uccinim ide, 2-undecy l-7 , 7 , 9 , 9 -tetr am eth y l-1 -
ox a-3, 8-diaZ a-4-ox o-s pir o-[ 4, 5 ]decane, a r eaction pr oduct of
7 , 7 , 9 , 9 -tetr am eth y l-2-cy cloundecy l-1-ox a-3, 8-diaZ a-4-ox
os pir o[ 4, 5 ]decane and epich lor oh y dr in, 1, 1-bis ( 1, 2, 2, 6 , 6
pentam eth y l-4-piper idy lox y car bony l) -2-( 4-m eth ox y ph eny l)
eth ene, ( 2, 2, 6 , 6 -tetr am eth y l-4-piper idy l)
h ex am eth y lenediam ine, dies ter of -4-m eth ox y
m eth y lenem alonic acid W ith 1, 2, 2, 6 , 6 -pentam eth y l-4
h y dr ox y piper idine, poly [ m eth y lpr opy l-3-ox y -4-( 2, 2, 6 , 6
tetr am eth y l-4-piper idy l]s ilox ane, r eaction pr oduct of m aleic
acid anh y dr ide-ot-ole? n-copoly m er W ith 2, 2, 6 , 6 -tetr am
eth y l-4-am inopiper idine or 1, 2, 2, 6 , 6 -pentam eth y l-4-am i
nopiper idine; Ox am ides : 4, 4' -diocty lox y ox anilide, 2, 2' -di
eth ox y ox anilide, 2, 2' -diocty lox y -5 , 5 ' -di-ter t-butox anilide,
2, 2' -didodecy lox y -5 , 5 ' -di-ter t-butox anilide, 2-eth ox y -2'
N ov . 21, 2013
eth y lox anilide, N , N ' -bis ( 3-dim eth y lam inopr opy l) ox am ide,
2-eth ox y -5 -tent-buty l-2' -eth ox anilide and its m ix tur e W ith
2-eth ox y -2' -eth y l-5 , 4' -di-ter t-butox anilide, m ix tur es of o
and p -m eth ox y -di s ub s tituted ox anilides and m ix tur es of o -
and p-eth ox y -dis ub s tituted ox anilides ; Tr iaZ ines : 2-( 2 -Hy
dr ox y ph eny l) -1, 3, 5 -tr iaZ ines , s uch as 2, 4, 6 -tr is ( 2 -h y dr ox y
4-octy lox y ph eny l) -1 , 3 , 5 -tr iaZ ine, 2-( 2 -h y dr ox y -4 -octy lox
y ph eny l) -4, 6 -bis ( 2, 4-dim eth y lph eny l) -1, 3, 5 -tr iaZ ine, 2-( 2, 4
dih y dr ox y ph eny l) -4, 6 -bis ( 2, 4-dim eth y lph eny l) -1 , 3, 5
tr iaZ ine, 2, 4-bis ( 2 -h y dr ox y -4 -pr opy lox y ph eny l) -6 -( 2, 4
dim eth y lph eny l) -1 , 3 , 5 -tr iaZ ine, 2-( 2 -h y dr ox y -4
octy lox y ph eny l) -4, 6 -bis ( 4 -m eth y lph eny l) -1 , 3 , 5 -tr iaZ ine,
2-( 2-h y dr ox y -4-dodecy lox y ph eny l) -4, 6 -bis ( 2, 4-dim eth
y lph eny l) -1 , 3 , 5 -tr iaZ ine, 2-( 2-h y dr ox y -4-tr idecy lox y ph e
ny l) -4, 6 -bis ( 2, 4-dim eth y lph eny l) - 1 , 3 , 5 -tr iaZ ine, 2- [ 2 -h y
dr ox y -4-( 2 -h y dr ox y -3 -buty lox y -pr opox y ) ph eny l] -4, 6 -bis ( 2,
4-dim eth y l) - 1 , 3 , 5 -tr iaZ ine, 2- [ 2 -h y dr ox y -4-( 2 -h y dr ox y -3 -
octy lox y -pr opy lox y ) ph eny l] -4, 6 -bis ( 2, 4-dim eth y l) - 1 , 3 , 5 -
tr iaZ ine, 2-[ 4( dodecy lox y /tr idecy lox y -2-h y dr ox y pr opox y )
2-h y dr ox y -ph eny l] -4, 6 -bis ( 2, 4-dim eth y lph eny l) -1 , 3 , 5 -
tr iaZ ine, 2-[ 2-h y dr ox y -4-( 2-h y dr ox y -3 -dodecy lox y pr opox y )
ph eny l]-4, 6 -bis ( 2, 4-dim eth y ph eny l) -1, 3, 5 -tr iaZ ine, 2-( 2
h y dr ox y -4-h ex y lox y ) ph eny l-4, 6 -diph eny l-1 , 3 , 5 -tr iaZ ine,
2-( 2-h y dr ox y -4-m eth ox y ph eny l) -4, 6 -diph eny l-1 , 3 , 5 -tr iaZ
ine, 2, 4, 6 -tr is [ 2-h y dr ox y -4-( 3 -butox y -2 -h y dr ox y pr opox y )
ph eny l] -1 , 3 , 5 -tr iaZ ine, 2-( 2-h y dr ox y ph eny l) -4-( 4 -m eth ox
y ph eny l) -6 -ph eny l- 1 , 3 , 5 -tr iaZ ine, 2- { 2-h y dr ox y -4- [ 3 -( 2
eth y lh ex y l-1-ox y ) -2-h y dr ox y pr opy lox y ]ph eny l} -4, 6 -bis ( 2,
4-dim eth y lph eny l) -1 , 3 , 5 -tr iaZ ine.
[ 007 8] Th e com pos itions des cr ibed h er ein m ay als o
include v ar ious optional additiv es . Ex am ples of s peci? c addi
tiv es include nucleating ag ents , antiblock ing ag ents , bas ic
co-s tabiliZ er s , bloW ing ag ents , ? ller s and r einf or cing ag ents ,
lig h t s tabiliZ er s and UV inh ibitor s , m etal inh ibitor s , s ur f ac
tants , inter calates , lactones , com patibiliZ er s , coupling ag ents ,
im pact m odi? er s , ch ain ex tender s , color ants , dy es , pig m ents ,
lubr icants , em uls i? er s , antis tatic ag ents , dis per s ants , m etallic
s alts of f atty acids , pr oces s ing aids , additional antiox idants ,
s y ner g is ts , ? uor es cent W h itener s , ? r e r etar dants , abr as iv es or
r oug h ening ag ents s uch as diatom aceous ear th , cr os s link ing
ag ents , f oam ing ag ents , th er m al s tabiliZ er s , r adiation s tabi
liZ er s , m old r eleas e additiv es , ig nition r es is tant additiv es
plas ticiZ er s , ? oW enh ancer s , anti-f og g ing ag ents , W ood,
W ood ? our and/or s lip ag ents and th e lik e. Th es e optional
additiv es and th eir m atch ing q uantities can be s elected
accor ding to par ticular r eq uir em ents f or th e pr oduct. Integ r a
tion of th es e optional additiv es to th e poly m er ic m ater ial can
be accom plis h ed by s uitable m eth ods th at ar e k noW n in th e
pr ior ar t.
[ 007 9 ] Suitable color ants include, inor g anic pig m ents , f or
ex am ple, copper , f er r ous /f er r ic ox ide, f er r ic ox ide, titanium
diox ide, ch r om e titanate, titanium y elloW , cobalt blue, ultr a
m ar ine blue, copper ch r om ite, m oly bdates , m ang anes e f er
r ite, ch r om ium h em atite, cobalt-Z inc alum inate, Z inc ox ide,
car bon black , Z inc s ul? de, g r aph ite, calcium car bonate,
h y dr ated alum inum s ilicate, copper poW der , napth ol r ed, ben
Z im idaZ ole, ph th alocy anine g r eens , ph th alocy anine blues ,
is oindolinones , diox aZ ines , bis diox aZ ines , q uinacr idones and
th e lik e. Suitable ? ak e pig m ents include br ig h t alum inum
? ak e, ex tr em ely ? ne alum inum ? ak e, m edium par ticle s iZ e
alum inum ? ak e, br ig h t m edium coar s e alum inum ? ak e, and
m ica ? ak e coated W ith titanium diox ide pig m ent als o k noW n
as pear l pig m ents . Th e color ants can be added to th e com po
s ition in am ounts r ang ing betW een about 0. 5 W t. % to about 3
US 2013/0310428 A1
W t. %, or in am ounts r ang ing betw een about 0. 4 W t. % to
about 2. 0 W t. %, bas ed on th e ov er all W eig h t of th e com pos i
tion.
[ 0080] Antis tatic ag ents f or th e pr es ent application can be
s elected f r om h y g r os copic com pounds W h ich can abs or b
m ois tur e f r om th e adj acent env ir onm ental air , and can cr eate
a conductiv e lay er of m ois tur e on th e poly m er s ur f ace th at
dis per s es th e ch ar g e. N on-lim iting ex am ples of antis tatic
ag ents W ould include q uater nar y am m onium com pounds and
am ines and th eir as s ociated der iv ativ es , ph os ph ate and f atty
acid es ter s , poly h y dr ic alcoh ol der iv ativ es , s ulf ated W ax es ,
alk ox y lated aliph atics and ar om atics .
[ 0081] Th e biocide concentr ate com pos ition of th e pr es ent
application can include ? ller s and ex tender s f or ex am ple,
ox ides of inor g anic m etals , par ticular ly , Mg , Al, Si, and Ti.
Als o, th e pr oteins der iv ed f r om s un? ow er , s oy bean, cotton
s eed, peanut, blood, eg g , r ape s eed and acety lated der iv ativ es
th er eof , g elatin, cr os s -link ed g elatin, v iny lacetate, and acy
lated pr oteins m ay be included in th e com pos ition.
[ 0082] Fur th er , lubr icants can be added to th e biocide con
centr ate com pos ition of th e pr es ent application in or der to
im pr ov e th e ? oW ch ar acter is tics of th e plas tic or poly m er
m atr ix em ploy ed th er ein. Polar ity , m elting point, and s olu
bility in th e poly m er m atr ix ar e k ey f actor s W h en a lubr icant
is s elected. Th e pr im ar y clas s es of lubr icants include am ides ,
es ter s , m etallic s tear ates , W ax es , and acids . Ex em plar y lubr i
cants of th e pr es ent application W ould include but ar e not
lim ited to lipids , g ly cer ides , W ax , f atty acids , f atty acid s alts ,
s tear ates of Al, Ca, Mg , and tin, m ag nes ium s ilicate, s ilicones
and th e lik e. For ex am ple, to enh ance th e ? oW pr oper ties of
th e poly m er m atr ices , anim al or v eg etables f at bas ed lipids
can be us ed.
[ 0083] BloW ing ag ents f r om ph y s ical and ch em ical or ig in
m ay als o be em ploy ed in th e pr oduction of th e com pos itions
des cr ibed h er ein. Gas s es lik es N 2, CO2, 02, or loW -boiling
liq uids s uch as s h or t-ch ain h y dr ocar bons , m ay be dis s olv ed in
th e poly m er ic m atr ix and can be v olatiliZ ed by th e r eleas e of
pr es s ur e or th e h eat of pr oces s ing . Ch em ical bloW ing ag ents
ar e s olids or liq uids th at g ener ate g as s es W h en decom pos ed
by th e h eat of pr oces s ing . Ch em ical bloW ing ag ents can be
des ig ned to decom pos e W ith in W ell-de? ned tem per atur e
r ang es th at can be loW er ed by th e addition of activ ating com
pounds . Th e ex am ples of bloW ing ag ents us ef ul in th e pr es ent
application include but ar e not lim ited to aZ odicar bonam ide,
dinitr opentam eth y lene tetr am ine, benZ ene s ulf ony l
h y dr aZ ide, p-toluene s ulf ony l h y dr aZ ide, p, p-ox y bis ( benZ ene
s ulf ony l h y dr aZ ide) , 5 -ph eny l tetr aZ ole, and s ulf ony l s em i
car baZ ides .
[ 0084] Th e biocide concentr ate com pos ition pr epar ed
accor ding to th e pr es ent application can be em ploy ed in v ar i
ous ? elds including but not lim ited to ? or al, indus tr ial, ag r i
cultur al, m edical, dental and/or v eter inar y . Th e lev el of bio
cide concentr ate us ed in v ar ious end-us e applications m ay be
f r om about 0. 01 W t. % to 0. 7 5 W t. %, m or e par ticular ly f r om
about 0. 07 5 W t. % to about 0. 6 W t. % of th e total com pos ition.
[ 0085 ] N on-lim iting ex am ples f or ty pical end-us e applica
tions W ould include ex tr uded and non-ex tr uded f ace ? ber s f or
ar ea r ug s , car pet back ing , latex adh es iv e back ing s us ed in
car pet. Additionally , th e biocide concentr ate of th e pr es ent
application can be us ed W ith m elt-pr oces s ed poly m er s in th e
? eld of liq uid ? ltr ation m edia, non-W ov en air ? ltr ation m edia;
outdoor f abr ics s uch as W ov en and non-W ov en car and boat
cov er s , tar ps , tents , canv as , duck ing , s ails , r opes , pool cov er s ,
um br ellas , aW ning s , s eating , cam ping g ear and g eotex tiles ,
N ov . 21, 2013
dr y W all, W eath er s tr ipping , ins ulation, h ous eW r ap and r oof
W r ap, W all cov er ing f abr ics ; ? oor ing m ater ials s uch as
cem ent, concr ete, m or tar and tile, s y nth etic m ar ble f or
k itch en and bath counter s and s ink s , s anitar y cer am ic com
pos ites , toilets , s h oW er s talls and cur tains ; s ealing m ater ials
s uch as adh es iv es f or plum bing and pack ag ing , g laZ ing f or
W indoW s , tile and v itr eous ch ina, g r out, pus h buttons f or
elev ator s , h andr ails f or s tair s , m ats , and k nobs , indus tr ial
eq uipm ent s uch as tape, tubing , bar r ier f abr ics , conv ey or
belts , ins ulator s and ins ulation f or W ir e and cable, plum bing
s upplies and ? x tur es , g as k ets , collection and s tor ag e eq uip
m ent s uch as including piping s y s tem s , s ilos , tank s and pr o
ces s ing v es s els and coating s us ed on th e ins ide of ? r e s y s tem
s pr ink ler pipes ; daily neces s ities s uch as ch opping boar ds ,
dis pos able g lov es , boW ls , k itch en dr ain bas k ets , k itch en
r ef us e bas k ets , k itch en k nif e h andles , ch ops tick s , tableW ar e,
table cloth s , napk ins , tr ay s , container s , bag s , lunch box es ,
ch ops tick cas es , dus ter s , s pong es , br oom s , m ops , W ipes ,
bath r oom s tools , W as h boW ls , pales , cupboar ds , s oap cas es ,
s h am poo h older s , tooth br us h h older s , tooth br us h es , r aZ or
blade h andles , W r apping ? lm s , f ood W r aps and pack ag ing ,
canteens , em er g ency W ater tank s , toilet s eats , h air br us h es ,
br us h br is tles , com bs , s cr ubber s , tools and tool h andles , cos
m etics and cos m etic container s , and cloth ing . Var ious oth er
contem plated us es include s tationer y and W r iting m ater ials
s uch as m ech anical pencils , ball-point pens , pencils , er as er s ,
? oppy dis k cas es , clipboar ds , clear paper h older s , f ancy
cas es , v ideo tape cas es , ph oto-m ag netic dis k s h ells , com pact
dis k cas es , des k m ats , binder s , book cov er s , W r iting paper and
pock et book s , autom obile par ts f or ex am ple, a s teer ing
W h eels , ar m r es ts , panels , s h if t k nobs , s W itch es , k ey s , door
k nobs , as s is t g r ips , tr uck liner s , conv er tible tops and inter ior
liner s , appliances s uch as r ef r ig er ator s , W as h ing m ach ines ,
v acuum cleaner s and bag s , air conditioner s , cloth ing ir ons ,
h um idi? er s , deh um idi? er s , W ater cleaner s , dis h W as h er s and
dr y er s , r ice cook er s , s tationar y and m obile teleph ones , copi
er s , touch panels f or ATM or r etail k ios k s , tex tile pr oducts
s uch as s ock s , panty h os e, under g ar m ents , inner liner s f or
j ack ets , apr ons , g lov es and h elm ets , toW els , bath ing s uits ,
toilet cov er s , cus h ion pads , cur tains , car pet ? ber s , ? ber ? ll f or
q uilts and pilloW s , pilloW s , s h eets , blank ets , bedcloth es , bed
ding , m attr es s tick ing , s leeping bag s , m attr es s cov er pads and
? lling , pilloW cov er s , nos e and m outh m as k s , toW els , caps ,
h ats , W ig s , etc. g oods r elated to public tr ans por tation s uch as
ov er h ead s tr aps , h andles and g r ips , lev er s , s eats , s eat belts ,
lug g ag e and s tor ag e r ack s s por ting g oods s uch as balls , nets ,
puck s , W h is tles , m outh pieces , r ack et h andles , per f or m ance
cloth ing , pr otectiv e g ear , h elm ets , indoor and outdoor ar ti?
cial tur f , s h oe lining s and r einf or cem ents , tools , s tr uctur es
and cer em onial obj ects us ed in ath letic ev ents and th e m ar tial
ar ts , m edical applications s uch as bandag es , g auZ e, cath eter s ,
ar ti? cial lim bs , im plants , ins tr um ents , s cr ubs , f acem as k s ,
s h ields , r eus able and dis pos able diaper s , s anitar y napk ins ,
tam pons , condom s , unif or m s , g oW ns and oth er h os pital g ar
m ents , m us ical ins tr um ents s uch as in r eeds , s tr ing s and
m outh pieces , contact lens , lens k eeper s and h older s , plas tic
cr edit/debit car ds , s and-lik e m ater ials f or play box es , s y n
th etic W ood, W ood-plas tic com pos ites ( W PC) , inj ection
m olding , ur eth ane coating s , j eW elr y and W r is t W atch bands .
[ 0086 ] Fur th er , th e biocide concentr ate com pos ition
des cr ibed h er ein can be em ploy ed in end-us e applications
s uch as poly m er W ood com pos ites and th eir r elated applica
tions s uch as ( i) cons tr uction m ater ials s uch as W indoW
f r am es , ex ter ior cladding , ex ter ior s iding , door f r am es , duct
US 2013/0310428 A1
ing , r oof s h ing les and r elated r oo? ine pr oducts , and ex ter ior
boar dW alk s and W alk W ay s ; ( ii) inter ior s and inter nal ? nis h es
f or ex am ple, inter ior paneling , decor ativ e pr o? les , o? ice f ur
nitur e, k itch en cabinets , s h elv ing , W or k tops , blinds and s h ut
ter s , s k ir ting boar ds , and inter ior r ailing s ; ( iii) autom otiv e
including door and h ead liner s , ducting , inter ior panels , das h
boar ds , r ear s h elv es , tr unk ? oor s , and s par e tir e cov er s ; ( iv )
g ar den and outdoor pr oducts s uch as deck ing , f ence pos ts and
f encing , r ails and r ailing s , g ar den f ur nitur e, s h eds and s h el
ter s , par k bench es , play g r ound eq uipm ent, and play g r ound
s ur f aces ; ( v ) indus tr ial ? oor ing , r ailing s , m ar ine piling s ,
m ar ine bulk h eads , ? s h ing nets , r ailr oad ties , and pallets .
[ 0087 ] Th e com pos ition of th e pr es ent application can als o
be em ploy ed in v ar ious m edical r elated end-us e applications
W h ich include but ar e not lim ited to dr es s ing s , pack ing s ,
m es h es , ? lm s , ? lter ing s ur f aces , ? lter s , inf us er s , dental ? os s
or s utur es , container s or v ials , antim icr obial com plex ( con
taining poly eth y lene, h ig h dens ity poly eth y lene, poly v iny l
ch lor ide, latex , s ilicone, cotton, r ay on, poly es ter , ny lon, cel
lulos e, acetate, car box y m eth y lcellulos e, alg inate, ch itin,
ch itos an and h y dr o? ber s ) and in liq uids , s olutions , dis per
s ions , or s us pens ions com pr is ing an antim icr obial m atr ix ,
s uch as topical s olutions , aer os ols , m is ts , s pr ay s , dr ops , inf u
s ions and ins tillation s olutions f or body cav ities and tubes
s uch as th e bladder , pr os tate, per inth eal, per ich ar cliar , pleu
r al, intes tinal and alim entar y canal. Ex am ples of oth er f or
m ulations include th os e th at ar e s uitable f or nas al m em
br anes , or al cav ity or g as tr ointes tinal tr act, f or m ulated W ith
antim icr obial m atr ices as loZ eng es , tooth pas tes , g els , poW
der s , coated dental im plants , dental ? os s or tape, ch eW ing
g um , W af er s , m outh W as h es or r ins es , dr ops , s pr ay s , elix ir s ,
s y r ups , tablets , or caps ules . Com pos itions m ay be appr opr i
ate f or v ag inal or r ectal adm inis tr ation dev is ed W ith an anti
m icr obial m atr ix as s uppos itor ies , dr es s ing s , pack ing s , tam
pons , cr eam s , g els , ointm ents , pas tes , f oam s , s pr ay s , and
s olutions f or r etention enem as or ins tillations .
[ 0088] Fur th er , cer tain as pects of th e pr es ent application
ar e illus tr ated in detail by W ay of th e f olloW ing ex am ples . Th e
ex am ples ar e g iv en h er ein f or illus tr ation of th e inv ention and
ar e not intended to be lim iting th er eof .
EX AMPLE 1
Pr oces s f or Pr epar ing Antim icr obial Plas tics or
Poly m er ic Matr ix
[ 0089 ] Plas tic s am ples containing th e biocide concentr ate
com pos ition containing antiox idant can be pr epar ed by m ix
ing W ith com m er cially av ailable ? ex ible PVC and pr oces s ing
at 17 5 C. in a br abender . Th e s am ples ar e pr es s ed to f or m
coupons f or tes ting pur pos es . A s am ple containing no biocide
is als o pr epar ed to s er v e as a neg ativ e contr ol ag ains t th e
s am ples of th e pr es ent inv ention.
EX AMPLE 2
Fung al Res is tance Tes t
[ 009 0] Fung al r es is tance tes ts ar e conducted accor ding to
ASTM G-21 . Br ie? y , a f ung al inoculum containing a m ix tur e
of As per g illus nig er ( ATCC 9 6 42) , Aur eobas idium pullulans
( ATCC 15 233) , Ch aelom ium g lobos um ( ATCC 6 205 ) , Peni
cillium f uniculos um ( ATCC 117 9 7 ) and Tr ich oder m a v ir ens
( ATCC 9 6 45 ) is pr epar ed to obtain a ? nal s por e concentr ation
of about 105 s por es /m l. Th e s am ples ( in tr iplicate) ar e placed
on Petr i-dis h es containing nutr ient s alts ag ar and incubated
N ov . 21, 2013
W ith th e s por e s us pens ion. Th e s am ples ar e th en incubated at
280 C. f or 4 W eek s and r ated W eek ly . Th e f ung al g r oW th of th e
s am ples is r ated on a s cale of 0 to 4 W h er e: 0 is no g r oW th , 1
is tr aces of g r oW th ( les s th an 10%) ; 2 is lig h t g r oW th ( 10
30%) ; 3 is m edium g r oW th ( 30-6 0%) and 4 is m ax im um
g r oW th ( m or e th an 6 0%) . Th e r ating s s h oW n in Tables 1 to 3
cor r es pond to th os e at th e end of th e tes t i. e. , on 4 W eek f or
th r ee dif f er ent com pos itions of com bination of biocidal
ag ents .
EX AMPLE 3
Pink Stain Tes t
[ 009 1] Pink Stain tes ts ar e conducted accor ding to ASTM
E1428. Br ie? y , an inoculum containing th e m icr oor g anis m
Slr eplov er licillium r eticulum ( ATCC 25 6 07 ) is pr epar ed. Th e
inoculum is s tr eak ed onto th e s ur f ace of Yeas t Malt Ex tr act
Ag ar . Th e s am ples ( in tr iplicate) ar e placed on th e inoculated
ag ar and incubated at 280 C. f or 14 day s . Th e deg r ee of
s taining is r ated on a s cale of 0-4 W h er e: 0 is no s tain; 1 is a
tr ace of s tain ( les s th an 10%) ; 2 is lig h t s tain ( 10-30%) ; 3 is
m edium s tain ( 30-5 0%) and 4 is m ax im um s tain ( m or e th an
5 0%) . Th e r ating s of th e pink s tain tes t ar e dis clos ed in Tables
1 to 3 f or th r ee dif f er ent s y ner g is tic biocide com pos itions .
EX AMPLE 4
Z one of Inh ibition
[ 009 2] Br ie? y a f ung al inoculum containing a m ix tur e of A.
nig er ( ATCC 9 6 42) and P f uniculos um ( ATCC 117 9 7 ) is
pr epar ed. Th e s por e s us pens ion is added to m olten Malt ag ar
to a ? nal concentr ation of 10 -105 s por es /m l, pour ed onto th e
petr i-dis h es and alloW ed to dr y . Th e s am ples ar e placed on th e
s ur f ace of th e s eeded ag ar and incubated at 280 C. f or 4 W eek s .
A Z one of inh ibition ar ound th e s am ple is r ated as + . Th e
abs ence of Z one of inh ibition is r ated as . Th e r es ults ar e
s h oW n in Tables 1 to 3 f or th r ee dif f er ent com binations of
biocidal ag ents .
TABLE 1
Ev aluation of s y ner g is tic com pos ition of Folpet + 3-Iodo-2
pr opy ny lbuty l-car bam ate ( IPBC) .
Biocide Antim icr obial Activ ity
Q uantity Fung al Z one
N am e ( in ppm ) Res is tance Tes t Pink Stain inh ibition
N o biocide i 4 4
OBPA 5 00 0 0 +
Folpet 3000 1 0
IPBC 5 00 1 2 +
Folpet + IPBC 7 00 + 300 1 0
Folpet + IPBC 9 10 + 39 0 0 0
Folpet + IPBC 9 45 + 405 0 0
Folpet + IPBC 9 80 + 420 0 0 +
Folpet + IPBC 105 0 + 45 0 0 0 +
Folpet + IPBC 16 00 + 400 0 0
Folpet + IPBC 1800 + 200 1 0
Folpet + IPBC 27 00 + 300 1 0
US 2013/0310428 A1
TABLE 2
Ev aluation of s y ner g is tic com pos ition of Folpet + Th iabendaZ ole ( TBZ ) .
Biocide Antim icr obial Activ ity
Q uantity Fung al
N am e ( in ppm ) Res is tance Tes t Pink Stain Z one inh ibition
N o biocide i 4 4
OBPA 5 00 0 0
Folpet 3000 1 0
TBZ 5 00 1 2
Folpet + TBZ 100 + 5 0 3 2
Folpet + TBZ 200 + 5 0 3 2
Folpet + TBZ 300 + 100 1 2
Folpet + TBZ 300 + 200 1 1
Folpet + TBZ 400 + 100 0 2
Folpet + TBZ 400 + 200 0 1
Folpet + TBZ 46 5 + 115 0 1
Folpet + TBZ 5 00 + 200 0 1
TABLE 3
Ev aluation of s y ner g is tic com pos ition of Folpet + 2-Octy l-4
is oth iaZ olin-3-one ( OIT) .
Biocide Antim icr obial Activ ity
Q uantity Fung al
N am e ( in ppm ) Res is tance Tes t Pink Stain Z one inh ibition
N o biocide i 4 4
OBPA 5 00 0 0
Folpet 3000 1 0
OIT 5 00 1 1
Folpet + OIT 5 00 + 200 3 1
Folpet + OIT 1000 + 400 1 0
Folpet + OIT 2000 + 800 2 0
[ 009 3] Ev aluation in End-Us e Applications
EX AMPLE 5
Ev aluation in Sw im m ing Pool Liner For m ulation
[ 009 4] A s w im m ing pool liner f or m ulation is s elected. Th e
indiv idual and s y ner g is tic biocidal com pos itions r es pectiv ely
IPBC, Folpet, OBPA and Folpet+ 1PBC ar e added and pr o
ces s ed in th e br abender as des cr ibed in Ex am ple 1. Th e e? i
cacy data f or each s am ple is tes ted accor ding to ASTM G21.
Gr ow th r ating s af ter 4 w eek s ar e des cr ibed in th e f ollow ing
Table 4.
TABLE 4
Biocide Fung al
N am e Q uantity ( in ppm ) Res is tance Tes t
Contr ol N o biocide 3
Folpet 2000 1
IPBC 5 00 1
Folpet + IPBC 7 00 + 300 0
OBPA 400 0
EX AMPLE 6
Ev aluation in W all Cov er ing For m ulation
[ 009 5 ] A w all cov er ing f or m ulation is em ploy ed f or ev alu
ating th e e? icacy of th e pr es ent biocide concentr ate com po
13
N ov . 21, 2013
s ition. Th e indiv idual and s y ner g is tic biocidal com pos itions
r es pectiv ely IPBC, Folpet, OBPA, Folpet+ 1PBC, and Folpet+
TBZ ar e added and pr oces s ed in th e br abender as dis clos ed in
Ex am ple 1. Th e e? icacy data f or each s am ple w as tes ted
accor ding to ASTM G21. Gr ow th r ating s af ter 4 w eek s ar e
des cr ibed in th e f ollow ing Table 5 .
TABLE 5
Biocide Fung al
N am e Q uantity ( in ppm ) Res is tance Tes t
Contr ol N o biocide 4
Folpet 2000 3
IPBC 1000 2
Folpet + IPBC 105 0 + 45 0 3
Folpet + TBZ 800 + 200 0
OBPA 6 00 0
EX AMPLE 7
Ev aluation in N on-W ov en For m ulations
[ 009 6 ] A non-w ov en f or m ulation w as em ploy ed f or ev alu
ating th e e? icacy of th e biocide concentr ate com pos ition. A
contr ol s am ple containing no biocide w as ev aluated v s .
s am ples containing dif f er ent lev els of th e biocide concentr ate
com pos ition ( Folpet+ 1PBC) . Th e e? icacy data f or each
s am ple w as tes ted accor ding to ASTM D 5 5 9 0. Br ie? y , m alt
plates ar e inoculated w ith f ung i to a ? nal concentr ation of
about 105 s por es /m l. Plates w er e incubated at 28 C. / 85 % RH
f or 4 w eek s . Gr ow th on th e s ur f ace of th e s am ple is r ated on
a s cale f r om 0 to 10 w h er e 0 is no g r ow th , 1 is 10%
g r ow th , 30 is 30% g r ow th and 10 is 100% g r ow th on th e
s am ple. Th e r es ults ar e des cr ibed in th e f ollow ing Table 6 .
TABLE 6
N am e Q uantity ( in ppm ) Fung al Res is tance tes ts .
Contr ol N o biocide 3
Folpet + IPBC 1, 400 + 6 00 1
Folpet + IPBC 2, 800 + 1, 200 0
[ 009 7 ] W h ile th is inv ention h as been des cr ibed in detail
w ith r ef er ence to cer tain pr ef er r ed em bodim ents , it s h ould be
appr eciated th at th e pr es ent inv ention is not lim ited to th os e
pr ecis e em bodim ents . Rath er , in v iew of th e pr es ent dis clo
s ur e, m any m odi? cations and v ar iations w ould pr es ent th em
s elv es to th os e s k illed in th e ar t w ith out depar ting f r om th e
s cope and s pir it of th is inv ention.
W h at is claim ed is :
1. A th er eto-s table, ar s enic-f r ee s y ner g is tic biocide con
centr ate com pos ition to pr ov ide enh anced m icr obicidal pr op
er ties to a poly m er m atr ix com pr is ing :
i. ( a) about 2. 5 to about 5 0. 0 w t % of tr ih alom eth y l-th io
ph th alim ide; and ( b) about 0. 5 to about 25 . 0 w t % of a
s econd biocide;
ii. about 0. 5 to 20 w t % of antiox idant;
iii. a car r ier ; and
iv . optionally , one or m or e additiv es .
2. Th e biocide concentr ate com pos ition accor ding to claim
1, w h er ein th e com pos ition is capable of w ith s tanding h ig h
pr oces s ing tem per atur es up to about 25 00 C.
US 2013/0310428 A1
3. Th e biocide concentr ate com pos ition accor ding to claim
1, W h er ein th e com pos ition is f r ee f r om ar s enic, s alts of
ar s enic, or g anic der iv ativ es of ar s enic and/ or inor g anic
der iv ativ es of ar s enic.
4. Th e biocide concentr ate com pos ition accor ding to claim
1, W h er ein s aid poly m er or poly m er m atr ix is s elected f r om
th e g r oup com pr is ing a poly ole? n, a poly acr y late, a poly v iny l
ch lor ide, a poly ur eth ane, a poly es ter , a W ood-plas tic com pos
ite, a poly car bonate, an elas tom er , a r ubber , an acr y lic, a
ny lon, a ? uor ocar bon, a s ty r enic and m ix tur es th er eof .
5 . Th e biocide concentr ate com pos ition accor ding to claim
1, W h er ein s aid tr ih alom eth y l-th io-ph th alim ide is
N -[ ( tr ich lor om eth y l) th io]ph th alim ide.
6 . Th e biocide concentr ate com pos ition accor ding to claim
1, W h er ein s aid s econd biocide is s elected f r om th e g r oup
cons is ting of g er m icides , bacter icides , f ung icides , alg icides ,
aq uaticides , h er bicides , ins ecticides , lar v icides , pes ticides ,
r odenticides , taeniacides and m ix tur es th er eof .
7 . Th e biocide concentr ate com pos ition accor ding to claim
1, W h er ein s aid s econd biocide is s elected f r om th e g r oup
cons is ting of N -buty l-l, 2-benZ is oth iaZ olin-3-one ( BBIT) ,
4, 5 -dich lor o-n-octy l-4-is oth iaZ olin-3-one ( D COIT) , tr i
clos an, 2-m eth y l-4-is oth iaZ olin-3-one ( MIT) , 1, 2-Ben
Z is oth iaZ olin-3-one ( BIT) , 5 -Ch lor o-2-m eth y l-4-is oth iaZ o
lin-3-one ( CMIT) , 2-Octy l-4-is oth iaZ olin-3-one ( OIT) ,
3-iodo-2-pr opy ny lbuty l-car bam ate ( IPBC) , ox y ? uor f en,
3-iodopr opy ny l car bam ate ( IPC) , 3-iodopr opy ny l-N -ph eny l
car bam ate ( IPPC) , th iabendaZ ole, ter butr y n, Z inc py r ith ione
( Z nPy ) , br onopol, diur on, deh y dr oacetic acid ( D HA) ,
daZ om et, s ilv er , car bendaZ im and m ix tur es th er eof .
8. Th e biocide concentr ate com pos ition accor ding to claim
1, W h er ein s aid antiox idant ag ent is s elected f r om th e g r oup
cons is ting of h inder ed ph enols , am ines , ar y l ph os ph ates ,
aZ oles and m ix tur es th er eof .
9 . Th e biocide concentr ate com pos ition accor ding to claim
8, W h er ein s aid antiox idant ag ent is s elected f r om 1, 3, 5 -tr is
( 3, 5 -di-t-buty l-4-h y dr ox y benZ y l) -is ocy anur ate, 1 , 3 , 5 -tr im
eth y l-2, 4, 6 -tr is -( 3, 5 di-ter t-buty l-4-h y dr ox y benZ y l) -ben
Z ene, 2, 2, m eth y lenebis ( 6 -t-buty l-4-m eth y l ph enol) , 4, 4
buty lidenebis ( 2-t-buty l-5 -m eth y lph enol) , 2, 5 -di-t
am y lh y dr oq uinone, 1 , 1 , 3 -tr is -( 2' m eth y l-4' -h y dr ox y -5 ' -t
buty lph eny l) butane, 1, 3, 5 tr is -( 4-ter t-buty l-3-h y dr ox y -2-6
dim eth y lbenZ y l) -1, 3, 5 tr iaZ ine-2, 4, 6 -( 1H, 3H, 5 H) -tr ione,
4, 4' -th iobis ( 2-t-buty l-5 -m eth y lph enol) , octadecy l-3-( 3' , 5 '
di-ter tbuty i-4 -h y dr ox y ph eny l) pr opionate, tr is -( 2, 4-di-ter tbu
ty l ph eny l) ph os ph ate and m ix tur es th er eof .
10. Th e biocide concentr ate com pos ition accor ding to
claim 1, W h er ein s aid car r ier is s elected f r om th e g r oup com
pr is ing a plas tic, a W ax , a plas ticiZ er and m ix tur es th er eof .
11. Th e biocide concentr ate com pos ition accor ding to
claim 10, W h er ein s aid plas ticiZ er is s elected f r om th e g r oup
com pr is ing diis onony l ph th alate, diis odecy l ph th alate, buty l
benZ y l ph th alate, eth er -es ter com pounds , g ly cer in tr ies ter s ,
g ly cer y l-1, 2-bis butanoate-benZ oate, g ly cer y l-1, 3 -bis bu
tanoate-benZ oate, g ly cer y l-1, 2-bis benZ oate-butanoate, g ly c
er y l-1, 3-bis benZ oate-butanoate, is ocy anur ates , es ter s of an
anh y dr os ug ar alcoh ol, ar y l ph os ph ates , ph enol alk anes ulph o
nates , dipr opy lene g ly col dibenZ oate, di( is ony l) cy cloh ex ane
N ov . 21, 2013
dicar box y late, diis ony l adipate, CS-Cl8 alk y l py r r olidones ,
epox y diZ ed s oy abean oil, epox idiZ ed lins eed oil, and m ix
tur es th er eof .
12. Th e biocide concentr ate com pos ition accor ding to
claim 1, W h er ein th e W t. r atio of ( i) : ( ii) is about 110. 5 to 1: 30
13. Th e biocide concentr ate com pos ition accor ding to
claim 1, W h er ein s aid additiv e is s elected f r om th e g r oup
cons is ting of color ants , pig m ents , th er m al s tabiliZ er s , ultr a
v iolet s tabiliZ er s , r adiation s tabiliZ er s , m old r eleas e additiv es ,
ig nition r es is tant additiv es , ? ller s , r einf or cing aids , bloW ing
ag ents , plas ticiZ er s , ? oW enh ancer s , lubr icants , anti-f og g ing
ag ents , anti-s tatic com pos itions , anti-block ing com pounds ,
lubr icants , h eat s tabiliZ er s , coupling ag ents , ? ller s , ex tender s ,
im pact m odi? er s , g las s ? ber s ? am e r etar dants W ood, W ood
? our , s lip ag ents and m ix tur es th er eof .
14. Th e biocide concentr ate com pos ition accor ding to
claim 1, W h er ein th e com pos ition is capable of inh ibiting or
k illing Staph y lococcus aur eus , Klebs iella pneum onia,
Ps eudom onas ar eug inos a, Bacillus s ubtilus , As per g illus
nig er , As per g illus ? av us , Os cillator ia tenius , Penicillin
f uniculos um , Ch aetom ium g lobos um , Aur eobas idium pullu
lans , Tr ich oder m a W r ens , Str eptov er ticillium r eticulum ,
Alter nar ia alter nator , Cur v ular ia s p. , Fus ar ium s p. , and/or
N ig r os por a s p.
15 . Th e biocide concentr ate com pos ition accor ding to
claim 1, W h er ein th e com pos ition is in th e f or m of a pellet, a
liq uid, a concentr ate or a poW der .
16 . Th e biocide concentr ate com pos ition accor ding to
claim 1, W h er ein s aid com pos ition is em ploy ed in th e ? eld of
? or al, indus tr ial, ag r icultur al, m edical, dental, v eter inar y ,
poly m er m atr ices , ex tr uded and non-ex tr uded f ace ? ber s ,
m elt-pr oces s ed poly m er s , outdoor f abr ics , ? oor ing m ater ials ,
s anitar y cer am ic com pos ites , s ealing m ater ials , indus tr ial
eq uipm ents , daily h ous eh old neces s ities , s tationer y and W r it
ing m ater ials , autom obile par ts , h om e appliances , s tationar y
and m obile ph ones , copier s , tex tiles , q uilts , pilloW s , blank ets ,
tr ans por tation g oods , s tor ag e r ack s , s por ting g oods , outdoor
ar ti? cial tur f , m edical applications , dental m ater ials , dental
applications , h os pital g ar m ents , s anitar y napk ins , m us ical
ins tr um ents , cr edit car ds , debit car ds , poly m er W ood com pos
ites , cons tr uction m ater ials , inter ior s and inter nal ? nis h es ,
g ar den and outdoor pr oducts , indus tr ial ? oor ing , r ailing s ,
m ar ine piling s , m ar ine bulk h eads , ? s h ing nets , r ailr oad ties ,
pallets , f ur nitur e, s y nth etic W ood, inj ection m olding s , ? x
tur es , ur eth ane coating s , r oo? ng m ater ials and/ or W ood-plas
tic com pos ites ( W PC) .
17 . Th e biocide concentr ate com pos ition accor ding to
claim 1, W h er ein s aid concentr ate is incor por ated into a poly
m er m atr ix in a W t. r atio of about 1 to 10 concentr ate to 9 9 to
10 poly m er m atr ix .
18. A m eth od of pr oces s ing a biocidal poly m er m atr ix
com pos ition com pr is ing adding to a poly m er m atr ix th e bio
cide concentr ate of claim 1 to pr oduce a th er m os table bio
cidal poly m er m atr ix and pr oces s ing s aid th er m os table bio
cidal poly m er m atr ix at an elev ated tem per atur e of about 25 00
C. to about 2800 C. , s ubs tantially W ith out th er m al deg r ada
tion of th e integ r ated biocides or dis color ation of th e poly m er
m atr ix .