ANTI-

HYPERLIPIDEMIC
AGENTS
IN PRACTICE





4FPH GROUP 2
AVEDILLO
BULAN
LO
MAPALO
MENDOZA
SANTOS








SIMVASTATIN

IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-
1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Trade Names
and
Manufacturer
Selling Price
(per tab)
Dosage
Form and
Strength
Clinical Indications
Pregnancy
Category
Zocor
(Merck Sharp &
Dohme)
PHP 28.56 10 mg tab Reduction of the risk of
CHD death, major
vascular & coronary
events, stroke,
hospitalization for
angina pectoris &
developing peripheral
macrovascular
complications in
patients w/ diabetes.
X
PHP 28.56 20 mg tab
PHP 36.00 40 mg tab
PHP 36.00 80 mg tab
Vidastat
(Therapharma)
PHP 27.58 10 mg tab Reduce increased total
plasma & LDL-
cholesterol in patients
w/
hypercholesterolemia
(type IIa) or combined
hyperlipidemia (type
IIb) in combination w/
dietary measures when
no adequate effect is
obtained w/ dietary &
nonpharmacological
measures alone (e.g.
fitness training & wt.
loss). For secondary
prevention of CHD.
X
PHP 30.82 20 mg tab
PHP 38.39 40 mg tab
PHP 38.39 80 mg tab
Cholestad
(Littman)
PHP 20.00 20 mg tab Prevention of CHD &
treatment of
hyperlipidemia.
X PHP 34.00 40 mg tab


Wilsim
(Hizon)






PHP 14.75 20 mg tab Reduction of LDL-
cholesterol,
apolipoprotein B &
triglycerides, to
increase HDL-
cholesterol in the
treatment of
hyperlipidemias
including
hypercholesterolemia &
mixed hyperlipidemia
(type IIa or IIb
hyperlipoproteinemias).
X
PHP 19.00 40 mg tab
Zivas
(Pascual)
PHP 13.27 10 mg tab Treatment of
hypercholesterolemia,
particularly in type IIa &
IIb
hyperlipoproteinemias,
hyperlipidemia,
ischemic heart disease,
CHD & severe renal
impairment.
X

ROSUVASTATIN

IUPAC Name
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-
5-yl]-3,5-dihydroxyhept-6-enoic acid
Trade Names
and
Manufacturer
Selling Price
(per tab)
Dosage
Form
Clinical Indications
Pregnancy
Category
Crestor
(Astra Zeneca)



PHP 26.33 5 mg tab Prevention of CV
events.
X
PHP 57.67 10 mg tab
PHP 70.17 20 mg tab
PHP 91.37 40 mg tab
Rosucol
(Ajanta)
PHP 16.47

10 mg tab Adjunct to diet for the
treatment of patients
w/ elevated serum
triglyceride (TG) levels.
X
PHP 26.33 20 mg tab

ATORVASTATIN

IUPAC Name
(3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-
dihydroxyheptanoic acid
Trade Names
and
Manufacturer
Selling Price
(per tab)
Dosage
Form
Clinical Indications
Pregnancy
Category
Lipitor
(Pfizer)
PHP 32.73

10 mg tab


Reduction of elevated
total & LDL cholesterol,
Apolipoprotein B &
triglycerides & increase
HDL cholesterol in
patients w/ primary
hypercholesterolemia.
X
PHP 37.17 20 mg tab


PHP 47.98 40 mg tab
PHP 48.10 80 mg tab
Atorwin
(sanofi-aventis)
PHP 19.24 10 mg film-
coated tab
Treatment of
hypercholesterolemia
& prevention of CV
disorders.
X
PHP 23.04 20 mg film-
coated tab
PHP 26.16 40 mg film-
coated tab










GEMFIBROZIL

IUPAC Name
5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
Trade Names
and
Manufacturer
Selling Price
(per tab)
Dosage
Form
Clinical Indications
Pregnancy
Category
Lipigem
(Littman)
PHP 11.00

300 mg tab Treatment of
hypertriglyceridemias
Mixed dyslipidemia:
Fredickson types IIA,
IIB, III, IV, V.
Hyperlipidemias
associated with
diabetes
Primary prevention of
CHD & MI in patients
with
hypercholesterolemia

X
Lopid OD
(Pfizer)
PHP 56.67 300 mg tab
PHP 94.12 60 mg tab
PHP 107.13 900 mg tab
Lipizile
(Integrated
Pharma)
PHP 10.35 300 mg tab
Reducel
(GXI)
PHP 11.31

300 mg tab

PHP 17.37 600 mg tab

FENOFIBRATE

IUPAC Name
Propan-2-yl 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoate
Trade Names
and
Manufacturer
Selling Price
(per tab)
Dosage
Form
Clinical Indications
Pregnancy
Category
Lipanthyl Supra
(Abbott)
PHP 62.67 160 mg
modified-
release tab
Hypercholesterolemia and
hypertriglyceridemia
alone, or combined (types
IIa, IIb, III, IV, and V
C
dyslipidemias) in patients
unresponsive to dietary
and other non-drug
therapeutic measures
(e.g., weight reduction or
increased physical
activity), particularly when
there is evidence of
associated risk e.g.,
hypertension and
smoking.
Fenoflex
(LR Imperial)
PHP 34.35

160mg cap

Treatment of types IIa, IIb,
III, IV, & V
hyperlipoproteinemias.


C
Fenogal
(SMB)
PHP 29.50 160mg cap Treatment of appropriate
cases of hyperlipidemia,
hypercholesterolemia
(type IIa), endogenous
hypertriglyceridemia (type
IVa) & mixed
hyperlipidemia (type IIb).

C
Lipway SR
(Cathay Drug)
PHP 34.69 250 mg
modified-
release cap
Treatment of
hyperlipidemias of type
IIa, IIb, III, IV, & V in
patients who have not
responded adequately to
diet & other appropriate
measures.

C
Nubrex
(Sandoz)
PHP 17.87 100 mg cap Treatment of types IIa, IIb,
III, IV, & V
hyperlipoproteinemias in
conjunction w/ dietary
modification.
C
PHP 31.50 300 mg cap










EZETIMIBE

IUPAC Name
(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-
hydroxyphenyl)azetidin-2-one
Trade Names
and
Manufacturer
Selling Price
(per tab)
Dosage
Form
Clinical Indications
Pregnancy
Category
Ezedoc
(Lupin) India
INR 6.78
(PHP 4.88)
10 mg tab Used as adjunctive
therapy to diet for the
reduction of elevated total
cholesterol, LDL, and
Apolipoprotein B in
patients with primary
(heterozygous familial and
non-familial)
hypercholesterolemia.


C
Ezetib
(Unisearch) India
INR 6.07
(PHP 4.37)
10 mg tab
Ezetrol
(Merck Sharp &
Dohme)
PHP 39.76


10 mg tab
Ezzicad
(Glenmark
Pharmaceuticals) -
India
INR 6.66
(PHP 4.80)


10 mg tab
Zetia
(Merck Sharpe &
Dohme/Schering-
Plough) - US
USD 5.16
(PHP 224.95)

10 mg tab