Pre GPAT Test 2014 (PCT WHO Old Quest.

) Date :30/8/14


1 Toluene Distillation method , determines

(a) water (b) Volatile oil

(c) both (d) none
2 Which reagent(s) required for detection of Inulin?

(a) Sulfuric acid (b) 1-naphthol

(c) Both (d) None
3 What volume of iodine in Mol/L is required to produce a blue or reddish blue color?

(a) 20 (b) 2

(c) 0.2 (d) 0.02
4 250 g Plant material should be taken as sample for all except..

(a) Leaves (b) Flower

(c) Seed (d) Bark
5 The bitterness value is expressed in units equivalent to the bitterness of a solution containing..

(a) 1g of quinine hydrochloride R in
1000 ml
(b) 1g of quinine hydrochloride R in
2000 ml

(c) 2g of quinine hydrochloride R in
2500 ml
(d) 2g of quinine hydrochloride R in
1000 ml
6 Unless otherwise specified in Plant analysis, all solutions indicated in the tests are prepared with

(a) Demineralized water of adequate purity (b) Distilled water of adequate purity

(c) Potable water of adequate purity (d) Distilled or demineralized water of
adequate purity
7 If A person who does not appreciate a bitter sensation when tasting a solution of 0.058 mg of quinine
hydrochloride R in 10 ml of water then

(a) He/She is not suitable to undertake
this determination.
(b) He/She is suitable to undertake this
determination.

(c) Test is repeated (d) none
8 For slightly soluble, how many number of millilitres (ml) of the solvent required?

(a) 30-100 parts (b) 100-1000 parts

(c) 1000-10 000 parts (d) more than 10000 parts
9 Test organisms used for Microbiological Assay of Bleomycin

(a) Micrococcus luteus (b) Bacillus subtilis

(c) Bacillus pumilus (d) Mycobacterium smegmatis
10 In Test for salmonella, Black or green colony formed with

(a) Xylose-lysine-desoxycholate agar (b) Deoxycholate-citrate agar

(c) Brilliant green agar (d) Bismuth sulphite agar
11 Test Organisms for Microbiological Assay of Erythromycin

(a) Staphylococcus aureus (b) Staphylococcus epidermidis

(c) Micrococcus luteus (d) Saccharomyces cerevisiae
12 It is generally accepted that terminally sterilized injectable preparations purporting to be sterile, when
processed in the autoclave, attain a

(a) 10
-6
microbial survivor probability (b) 10
-8
microbial survivor probability

(c) 10
-4
microbial survivor probability (d) 10
-2
microbial survivor probability
13 The D-value of a biological indicator preparation of Bacillus stearothermophilus is ________ under the
total process parameters,

(a) 3.5 minutes (b) 1.5 minutes

(c) 5 minutes (d) 8 minutes
14 As per Indian Pharmacopoeia, how many container required to determine the number of colony-
forming units (CFU) for the freeze-dried vaccine.

(a) 3 (b) 4

(c) 5 (d) 6
15. RESERPINE is derived from (2001-2.5)
(a) Squalene (b) Homoserine (c) Tryptophan and tryptophan (d) Azepine
16. CASCAROSIDE A is an example of (2002-2.1)
(a) O-Glycoside (b) C-Glycoside (c) N-Glycoside (d) O and C-Glycoside
17 The extraction of steroidal saponins on commercial scale is from
(a) Dioscorea (b) Digitalis (c) Datura (d) Trigonella
18. The pKa of lidocaine is 7.9. If the pH of infected tissue is 8.9 the fraction of the drug in the ionized
form will be (2002-2.22)
(a) 1% (b) 10% (c) 90% (d) 99%
19. A conductivity cell consists of (1999-1.12, 2002-2.19)
(a) Two platinized- platinum electrode (b) A platinum calomel electrode system
(c) A platinum tungsten electrode system (d) A glass calomel electrode system
20. The mechanism of action for DACTINOMYCIN is (2001-2.18)
(a) Inhibition of Topoisomerase II (b) Cross link DNA
(c) Inhibition function of Microtubules (d) Inhibits DNA polyomerase
21. A typical example of exotoxin is (2002-2.20)
(a) Lipid-A (b) Cytokinine (c) Tetanospasmin (d) Tuberculin
22. For thermophilic micro-organism, the minimum growth temperature (
o
C) required is (2003-15)
(a) 20 (b) 37 (c) 45 (d) 65
23. X-ray spectral lines K doublet arises from transition of electron from (2003-10)
(a) M shell to K shell (b) L shell to K shell (c) L shell to M shell (d) M shell to L shell
24. The method of expressing magnetic field strength is (2003-11)
(a) Cycles/Sec (b) Pulse/Sec (c) Debye units (d) Gauss
25. One of the substance is used as muco adhesive (2000-1.1)
(a) Acacia (b) SCMC (c) Burnt sugar (d) Both a and b
26. The phenomenon of increasing the solubility of weak electrolyte and non polar molecules by the
addition of a water miscible solvent in which the drug has good solubility is called. (2002-1.6)
(a) Complexation (b) Cosolvancy (c) Solubilization (d) Hydrotrophy
27. How many parts of 10% ointment be mixed with 2 parts of 15% ointment to get 12% ointment?
(2003-21)
(a) 2 (b) 3 (c) 5 (d) 6
28. What is the proportion of NaCl required to render a 1.5% solution of drug isotonic with drug plasma?
The freezing point of 1% w/v solution of drug is -0.122
o
C and that of NaCl is -0.576
o
C (2003-39)
(a) 0.65% (b) 0.585% (c) 0.9% (d) 0.5%
29. An original license or renewed license to sell drugs remains valid up to (2000-1.25)
(a) 31
st
March (b) 30
th
June (c) 31
st
January (d) 31
st
December




1 A 16 D
2 C 17 A
3 D 18 A
4 D 19 A
5 B 20 B
6 D 21 C
7 A 22 C
8 B 23 B
9 D 24 D
10 D 25 D
11 C 26 B
12 A 27 B
13 B 28 B
14 C 29 D
15 c