FORMULATION AND EVALUATION OF MUCOADHESIVE

BUCCAL TABLETS OF ONDANSETRON HCL

M. Pharm. Dissertation Protoco
Submitted to the
Ra!i" #an$hi Uni"ersit% o& Heath Sciences' (arnata)a
Ban*aore.
By
Mr. VI+A, V PA-AR B. Pharm.

Under the Guidance of
Dr. C.C. PATIL M.Pharm, ph.D
Pro&essor . Hea$
DEPARTMENT OF PHARMACEUTICS
B L D E A/S COLLE#E OF PHARMAC,
BI+APUR0123456
754607548
Ra!i" #an$hi Uni"ersit% o& Heath Sciences' (arnata)a
Ban*aore.
ANNE9URE II
PROFORMA FOR RE#ISTRATION OF SUB+ECTS FOR DISSERTATION

1)

Name of candidate and address
(n B!oc" #etters)
Mr. VI+A,.V.PA-AR
AT0MA#AR-ADI
POST0CHANDAPURI
TAL0 MALSHIRAS
DIST0 SOLAPUR0846 645
$)

Name of the nstitute
B.L.D.E.A/S COLLE#E OF
PHARMAC,' BI+APUR0123 456
%) &ourse of study and sub'ect( M. PHARM IN PHARMACEUTICS.
)) Date of admission of course( 7:04707547
*) +it!e of the topic; ,
<FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL
TABLETS OF ONDANSETRON HCL=.
-) Brief .esume of this intended /or" ;0
3.4 Need for the study Encos>re0I
3.7 .e0ie/ of #iterature Encos>re0II
3.6 1b'ecti0es of study Encos>re0III
$
2) Materia!s and Methods ;0
2.1 Source of data Encos>re0IV
2.$ Method of co!!ection of data (nc!udin3 samp!in3 procedure, if any)
Encos>re0IV
2.% Does the study re4uire any in0esti3ation or inter0entions to be conducted on
patients of humans or anima!s5 f so, p!ease describe brief!y.
000NO,,,,
2.) 6as ethica! c!earance been obtained from your institution in case of 2.%5
000NOT APPLICABLE,,,,

7) #ist of .eferences Encos>re0V

8)

Si3nature of the candidate

19)

.emar"s of the Guide

Encos>re0VI
11) Name and desi3nation of
(in b!oc" !etters)
11.1 Guide

11.$ Si3nature


Dr. CHANDRASHE(AR.C. PATIL
Pro&essor . Hea$'
De?t. o& Pharmace>tics
B.L.D.E.A/S COLLE#E OF PHARMAC,'
BI+APUR0123456.
11.% &o,Guide (if any) ,,,,,,,,,,,,
%
11.) Si3nature ,,,,,,,,,,,,
11.* 6ead of Department
11.- Si3nature
0000000000000
1$)

1$.1 .emar"s of the
&hairman and Principa!

1$.$ Si3nature
This st>$% Can @e carrie$ o>t in o>r a@orator%
Encos>re0I
)
3A Brie& res>me o& the inten$e$ Bor).
3.4A Nee$ &or the st>$%; 0
Bucca! de!i0ery of dru3s pro0ides an attracti0e a!ternati0e to the ora! route of dru3
administration, particu!ar!y in o0ercomin3 the disad0anta3es associated /ith the !ater
mode of dosin3. Moreo0er, the ora! ca0ity is easi!y accessib!e for se!f medication and can
be prompt!y terminated in case of to:icity 'ust by remo0in3 the dosa3e form from bucca!
ca0ity. t is a!so possib!e to administer dru3 to patients /ho cannot be dosed ora!!y 0ia
this route.
1
;mon3 the 0arious transmucosa! routes, bucca! mucosa has e:ce!!ent accessibi!ity, an
e:panse of smooth musc!e and re!ati0e!y immobi!e mucosa, hence suitab!e for
administration of retenti0e dosa3e form. +echnica!!y, an idea! bucca! adhesi0e system
must ha0e the fo!!o/in3 properties( (1) maintains its position in the mouth for a fe/
hours, ($) re!eases the dru3 in a contro!!ed fashion, and (%) pro0ides dru3 re!ease in a
unidirectiona! /ay to/ard the mucosa.
$
+hree different cate3ories of dru3 de!i0ery fa!! /ithin the ora! ca0ity( sub!in3ua!, bucca!,
and !oca!. +he sub!in3ua! mucosa is re!ati0e!y permeab!e, 3i0in3 rapid absorption and
acceptab!e bioa0ai!abi!ities of many dru3s, and is con0enient, accessib!e, and 3enera!!y
/e!! accepted.
%
+he dru3 direct!y reaches to the systemic circu!ation throu3h the interna! 'u3u!ar 0ein and
bypasses the dru3s from the hepatic first pass metabo!ism, /hich !eads to hi3h
bioa0ai!abi!ity. +he other ad0anta3es of bucca! dru3 de!i0ery inc!ude( !o/ en<ymatic
acti0ity, suitab!e for dru3s or e:cipients that mi!d!y and re0ersib!y dama3e or irritate the
mucosa, pain!ess dru3 administration, easy dru3 /ithdra/a!, possib!e to inc!ude the
permeation.
)
+herefore, the ora! mucosa may be potentia! site for contro!!ed or sustained dru3 de!i0ery.
+he permeabi!ity of the ora! mucosa is !o/= hence, the ora! mucosa cou!d be uti!i<ed to
potent dru3s /hich are re4uired in sma!! doses.
*
n this study, ondansetron 6&! (1DN) /as se!ected as a mode! dru3= it is a se!ecti0e
serotonin *,6+% receptor b!oc"in3 a3ent.
-
t is a potent antiemetic dru3 used in the
treatment of chemotherapy or radiotherapy induced emesis and a!so used in the ear!y
*
onset of a!coho!ism. ;!thou3h, it is /e!! absorbed in the 3astrointestina! tract= 1DN
under3oes first pass,metabo!ism resu!tin3 in !o/ bioa0ai!abi!ity. +he !o/ dose ()m3) and
ma:imum !i"e (7m3) and !o/ mo!ecu!ar /ei3ht (%-*.7- Da) ma"e it as a suitab!e
candidate for bucca! de!i0ery. t has been c!assified as B&S &!ass dru3 o/in3 to its
!o/ permeabi!ity and hi3h so!ubi!ity. +herefore, it /as e:co3itated to use permeation
enhancer in de!i0erin3 1DN throu3h bucca! mucosa.
2

t is effecti0e in the treatment of nausea and 0omitin3, t has a ha!f,!ife %,* h and ora!
bioa0ai!abi!ity is > -9 ?. 1D6 sho/s promisin3 pharmaco"inetics and physicochemica!
properties hence this dru3 /as se!ected as mode! dru3s for this in0esti3ation.
7
-
Encos>re0II
3.7A Re"ieB o& iterat>re; 0
1) #>$a a$it%a et al., ha0e de0e!oped and e0a!uate contro!!ed re!ease mucoadhesi0e
bucca! tab!ets of #isinopri!. a dru3 /ide!y used in the treatment of hypertension.
6o/e0er, its e:tensi0e first pass metabo!ism resu!ts in poor bioa0ai!abi!ity. +he
ob'ecti0e of present research /or" is to desi3n and e0a!uate the contro!!ed re!ease
of mucoadhesi0e bucca! tab!ets of #isinopri! /ith a 3oa! to increase the
bioa0ai!abi!ity, reduce dosin3 fre4uency and impro0e patient comp!iance. +he
tab!ets /ere prepared usin3 &arbopo!8%), 6ydro:y propy! methy! ce!!u!ose
(6PM&), hydro:y ethy! ce!!u!ose (6@&) as mucoadhesi0e po!ymers. ;na!ysis of
#isinopri!e is done by UA 0isib!e spectrophometer usin3 /a0e!en3th $19nm.
.esu!ts of in-vitro s/e!!in3 study indicate that the +ota! si: different formu!ations
(B1 to B-) of #isinopri! bucca! tab!ets /ere prepared by direct compression
techni4ues usin3 0arious proportions of po!ymers and e:cipients. n order to
se!ect the best formu!ations, 0arious e0a!uation parameters /ere chec"ed and
sub'ected to in-vitro disso!ution studies and their re!ease profi!es.
8
2) Sat%a@rata Bhan!a

et al., ha0e prepared and e0a!uate of mucoadhesi0e bucca!
tab!ets of +imo!o! ma!eate. +he best in-vitro dru3 re!ease profi!e /as achie0ed
/ith the formu!ation B* /hich contains the dru3, &arbopo! 8%)p and 6PM& C)M
in the ratio of 1($.*(19. +he in vitro re!ease of +imo!o! ma!eate /as performed
under sin" conditions (Phosphate buffer P6(-.7, %2D9.*E&, rpm *9) usin3 USP,
FFA disso!ution apparatus type . +he formu!ation B*, containin3 19 m3 of
+imo!o! ma!eate e:hibited 2 h sustained dru3 re!ease i.e. 87.17 ? /ith desired
therapeutic concentration. +he samp!es /ere fi!tered throu3h Ghitman fi!ter paper
No.)9 and ana!y<ed for +imo!o! after appropriate di!ution by UA
spectrophotometer at $8- nm. +he in-vitro re!ease "inetics studies re0ea! that a!!
formu!ations fits /e!! /ith <ero order "inetics fo!!o/ed by Corsmeyer,Peppas,
first order and then 6i3uchiHs mode! and the mechanism of dru3 re!ease is non,
Bic"ian diffusion. B+. studies sho/ed no e0idence on interactions bet/een dru3,
po!ymers, and e:cipients..n conc!usion, the resu!ts indicated that the prepared
2
sustained,re!ease tab!ets of +M cou!d perform therapeutica!!y better than
con0entiona! tab!ets /ith impro0ed efficacy and better patient comp!iance.
19
3) # C)inci et al., ha0e de0e!oped a bucca! bioadhesi0e nicotine tab!et formu!ation
for smo"in3 cessation. &arbomer (&arbopo!I82)P NB) (&P) and a!3inic acid
sodium sa!t (Na;!3) /ere used as bioadhesi0e po!ymers in combination /ith
hydro:ypropy! methy!ce!!u!ose (6PM&) at different ratios. Ma3nesium carbonate
/as incorporated into the formu!ations as a p6 increasin3 a3ent. ; decrease in p6
of the disso!ution medium to acidic 0a!ues /as a0oided by incorporation of
ma3nesium hydro:ide into the formu!ations. +he de0e!oped formu!ations re!eased
N6+ for 7 h period, and remained intact e:cept for the formu!ation containin3
&P( 6PM& at $9(79 ratios. +ab!ets /ere prepared by direct compression of the
mi:ture of 6PM& either /ith &P or Na;!3 at different ratios. +he re!ease of
N6+ from tab!ets /as studied usin3 modified Bran< diffusion ce!!s. +he samp!es
/ere fi!tered and assayed for N6+ at $*8 nm usin3 a UA 1-9; Shimad<u
spectrophotometer. t /as sho/n that /ith the de0e!oped formu!ations, the N6+
re!ease and bioadhesion properties of bucca! tab!ets can be contro!!ed by chan3in3
the po!ymer type and concentration.
11
4) Ca>m R et al., ha0e formu!ated ora! contro!!ed re!ease matri: tab!ets of #osartan
potassium. Bi!ayer nicotine mucoadhesi0e tab!ets /ere prepared and e0a!uated to
determine the suitabi!ity of the formu!ation as a nicotine rep!acement product to
aid in smo"in3 cessation. ; ran3e of formu!ations containin3 9J*9? ///
&arbopo! 8%)I and 9J*9? /// hydro:ypropy!ce!!u!ose (6P&) /ere prepared and
tested for adhesi0e properties and dru3 re!ease. Mucoadhesion /as assessed usin3
bo0ine bucca! mucosa. Pea" detachment force of the tab!ets /as found to reach a
ma:imum at $9? /// &arbopo! 8%)I, /hi!st /or" of adhesion continued to
increase /ith &arbopo! 8%)I concentration. 6P& concentrations of $9J%9? ///
/ere found to pro0ide nicotine hydro3en tartrate (N6+) re!ease approachin3 <ero
order "inetics o0er a ) h test period. ; combination of $9? /// &arbopo! 8%)I
and $9? /// 6P& /as thus found to pro0ide suitab!e adhesion and contro!!ed
dru3 re!ease. +he eff!uent from the ce!!s /as co!!ected o0er a ) h period and
assayed for nicotine at certain time inter0a!s usin3 U.A. detection at $*8 nm. In-
7
vitro nicotine re!ease Disso!ution testin3 /as initia!!y carried out to in0esti3ate the
effect of 6P& on N6+ re!ease. +he rate of N6+ re!ease from the &.#Hs and
bi!ayer tab!ets /as in0esti3ated usin3 USP (FF) apparatus A. t has been
proposed that mucoadhesion occurs in three sta3es (Duchene et a!., 1877). +he
first sta3e in0o!0es the formation of an intimate contact bet/een the
mucoadhesi0e and the mucus. Second!y, the mucoadhesi0e macromo!ecu!es s/e!!
and interpenetrate /ith the mucus macromo!ecu!es, becomin3 physica!!y
entan3!ed. +hird!y, these mo!ecu!es interact /ith each other 0ia secondary, non,
co0a!ent bonds such as hydro3en bonds.
1$
5) Paoo #i>nche$ia et al.' ha0e prepared bucca! tab!ets of ch!orhe:idine usin3
dru3,!oaded chitosan microspheres. +his in0esti3ation dea!s /ith the de0e!opment
of bucca! formu!ations (tab!ets) based on chitosan microspheres containin3
ch!orhe:idine diacetate. +he micropartic!es /ere prepared by a spray,dryin3
techni4ue, their morpho!o3ica! characteristics /ere studied by scannin3 e!ectron
microscopy and the in 0itro re!ease beha0iour /as in0esti3ated in p6 2.9 USP
buffer. &h!orhe:idine in the chitosan microspheres disso!0es more 4uic"!y in 0itro
than does ch!orhe:idine po/der. +he anti,microbia! acti0ity of the micropartic!es
/as in0esti3ated as minimum inhibitory concentration, minimum bacteria!
concentration and "i!!in3 time. +he !oadin3 of ch!orhe:idine into chitosan is ab!e
to maintain or impro0e the anti,microbia! acti0ity of the dru3. +he impro0ement is
particu!ar!y hi3h a3ainst Candida albicans. +his is important for a formu!ation
/hose potentia! use is a3ainst bucca! infections. Dru3,empty micropartic!es ha0e
an anti,microbia! acti0ity due to the po!ymer itse!f. Bucca! tab!ets /ere prepared
by direct compression of the micropartic!es /ith mannito! a!one or /ith sodium
a!3inate. ;fter their in-vivo administration the determination of ch!orhe:idine in
sa!i0a sho/ed the capacity of these formu!ations to 3i0e a pro!on3ed re!ease of
the dru3 in the bucca! ca0ity.
1%
6) Ahma$ Mahmoo$ M>mtaD et al., ha0e de0e!oped bioadhesi0e bucca! tab!ets
containin3 triamcino!one acetonide in hea!thy 0o!unteers. Bioadhesi0e bucca!
tab!ets prepared from different ratios of po!y (acry!ic acid,$,*,dimethy!,!,*,
he:adiene) (P;D6) and hydro:ypropy!methy!ce!!u!ose (6PM&) /ith and /ithout
8
triamcino!onc acctonidc (+;;) has been in0esti3ated in the bucca! ca0ities of
hea!thy human 0o!unteers. +he inc!usion of hi3her percenta3es of 6PM&
pro0ides more pro!on3ed re!ease of dru3 throu3h its properties of 3e!!in3 and s!o/
disso!ution. 6o/e0er, adhesion of the tab!et is reduced in the e:cessi0e f!o/ of
sa!i0a and there is a!so a tendency for the tab!et to be dis!od3ed from the mucosa.
+he tab!et /ith a P;D6K6PM& ratio of *9(*9 seems to pro0ide a suitab!e
compromise for 3ood bioadhesion and pro!on3ed re!ease of dru3. +he
triamcino!one acetonide concentration /as determined by a UA
spectrophotometer (6itachi, Mode! $999U, and Lapan) at $)9.7 nm. Sho/s that
tab!et hydrates and s/e!!s immediate!y and disinte3ration occurs /ithin %9 min
/hich reaches the ma:imum at 1.9 h. +he re!ati0e!y !ar3e fa!! in /et /ei3ht after
1.* h is probab!y due to difficu!ty in remo0in3 a!! the s/e!!ed P;D6 partic!es
from the mucosa.
1)
7) Ra!esh (hanna MA et al., ha0e prepared Preparation bioerodib!e bucca! tab!ets
containin3 c!otrima<o!e. Buccoadhesi0e erodib!e tab!ets for !oca! de!i0ery of
c!otrima<o!e (&#+) to the ora! ca0ity /ere de0e!oped usin3 different bio,adhesi0e
po!ymers a!on3 /ith so!ub!e e:cipients !i"e mannito! and po!yethy!ene 3!yco!,
-999. ;n apparatus simu!atin3 the in-vivo conditions of the mouth /as desi3ned
in order to assess in-vitro, the bio,adhesi0e performance and re!ease
characteristics of these tab!ets. +he in-vitro adhesion time and re!ease
characteristics /ere found to be a function of the type of po!ymer and a!so the
tota! composition of the tab!ets. n 0i0o e0a!uation of p!acebo tab!ets in hea!thy
human 0o!unteers indicated a !inear and positi0e corre!ation bet/een the in-vitro
and in-vivo adhesion time.
1*
Encos>re0III
19
3.6A O@!ecti"es o& the st>$%; 0
+he present study is p!anned /ith the fo!!o/in3 ob'ecti0es; 0
1) +o prepare standard ca!ibration cur0e of 1ndansetron 6c!.
$) +o prepare mucoadhesi0e bucca! tab!ets by /et 3ranu!ation method usin3 po!ymer
!i"es, 1) Natura! po!ymer, chitosan, Sodi.;!3inate etc. and Semi, Synthetic
po!ymers, 6PM&, @& etc
%) Dru3, e:cipients compatibi!ity study by B+. Spectroscopy.
)) +o perform e0a!uation parameter !i"es
1. ;ppearance, thic"ness, hardness, /ei3ht 0ariation, friabi!ity test.
$. Determination of s/e!!in3.
%. Surface p6 study.
). Bioadhesion.
*. .esistance time
-. In-vitro disso!ution study usin3 USP FF (@!ectro !ap, +D+
9-p) ana!ysed them by usin3 UA,Spectrometer (pharmaspec
1299, Shimad<u, Lapan).
2. Stabi!ity testin3.
7. In-vitro permeation studies of the optimi<ed formu!ations.
Encos>re0IV
11
7) Materials and Methods: -
:.4A So>rce o& $ata; 0
Primar% $ata; 0 +his data /i!! be co!!ected by conductin3 !aboratory
e:periments and recordin3 the obser0ation.
Secon$ar% $ata; 0 +his /i!! be co!!ected from 0arious 'ourna!s and te:tboo"s.
:.7A Metho$ o& coection o& $ata; 0
+he study is p!anned to co!!ect the data from the !aboratory,based e:periments,
/hich inc!ude the fo!!o/in3(
1) Preparation of 1ndansetron hc! tab!ets by usin3 different po!ymers by /et
3ranu!ation method.
$) &ompatibi!ity study of dru3 /ith 0arious po!ymers /i!! be carried out by usin3
B+,.,7)99 S Shimad<u, Lapan.
%) @0a!uation parameter such as, appearance, thic"ness, hardness, /ei3ht 0ariation
test, friabi!ity test, dru3 content uniformity, bioadhesion, in,vitro disso!ution
studies, s/e!!in3 inde:, in-vitro resistance time.
)) In-vitro permeation studies /i!! be carried out for the optimi<ed formu!ation.
*) +he stabi!ity studies of the formu!ation /i!! be carried out as per &6 3uide!ines
and data /i!! be co!!ected.
ENCLOSURE0V

1$
List o& re&erences; 0
1. Mada0 Deepa" .+, ;yyappan S, hanmu3am C, Sundaramoorthy and +.
Aetriche!0an. De0e!opment and in-vitro @0a!uation of Buccoadhesi0e
Metoc!opramide 6ydroch!oride +ab!et Bormu!ations. nternationa! 'ourna! of
pharmatech .esearch coden , $911= %(*1-,*$*.
2. Prasanth Aasantha Ais/anadhan, ;nand Pado!e, ;bin ;braham and Sam
+homarayi! Mathe/. Bucca! +ab!ets of #isinopri! by Direct &ompression Method
for Bucca! Dru3 De!i0ery. nternationa! research Lourna! of Pharmaceutica!s,
$91$= $(%9,%7.
3. Pate! CA, Pate! ND, Dodiya 6D, She!at PC. Bucca! Bioadhesi0e Dru3 De!i0ery
System. ;n 10er0ie/. nternationa! Lourna! of Pharmaceutica! and Bio!o3ica!
;rchi0es, $911= $($)( -99,-98.
4. C Na3a .a'u, S Ae!muru3an, B Deepi"a , Sundar Ainushitha . Bormu!ation and
in0itro e0a!ution of bucca! tab!et of Metopro!o! tartrate. nternationa! Lourna! of
pharmacy and Pharmaceutica! science, $911= %( $%8,$)-.
5. S/amy PA, Cina3i MB, Biradar SS, Gada SN and Shi!pa 6. Bormu!ation Desi3n
and @0a!uation of Bi!ayer Bucca! +ab!ets of Granisetron 6ydroch!oride. ndian
Lourna! of Pharmaceutica! @ducation and .esearch, $911= $)$,$)2.
6. Upendra na3aich , Aandana chaudhary

, .oopa "ar"i

, ;"ash yada0

, Pra0een
Sharma

. Bormu!ation of medicated che/in3 3um of ondansetron hydroch!oride
and its pharmaco"inetic e0a!uations. nternationa! Lourna! of Pharmaceutica!
science and research, $919= 1($)( %$,)9.
7. M Pra0een Cumar, M .a'endra Prasad, M Pramod and A Prabha"ar .eddy.
@ffect of permeation enhancer on e:,0i0o permeation of 1ndansetron hc! bucca!
tab!ets. nternationa! Lourna! of Pharmaceutica! science and research, $911= $
(11)( $7)1,$7)*.
8. Syed ;me<uddin ;<har, Putta .a'esh Cumar, Ai0e" Sood and Somashe"ar
Shya!e. Studies on direct!y compressed ondansetron hydroch!oride mucoadhesi0e
bucca! tab!ets. Lourna! of app!ied pharmaceutica! science, $91$= $ (*)( 199,19*.
9. Guda ;ditya, Ganesh Cumar Gudas

, Manasa Bin3i

, Suba! Debnath

, AA
.a'esham

. Desi3n and @0a!uation of &ontro!!ed .e!ease Mucoadhesi0e Bucca!
+ab!ets of #isinopri!. nternationa! Lourna! of current Pharmaceutica! research,
$919 = $ ()) ( $),$2.
1%
10. Satyabrata Bhan'a

, P @!!aiah

, Su'it Cumar Martha

, Pratit Canchan Sahu

, Sandip
Prasad +i/ari

, Bibhuti Bhusan Pani3rahi

, Deba'yoti Das

. Bormu!ation and in
vitro e0a!uation of mucoadhesi0e bucca! tab!ets of +imo!o! ma!eate. nternationa!
Lourna! of Pharmaceutics and Medica! .esearch, $919= 1())( 1$8,1%).
11. G N"inci, S Sene!, & G Gi!son , M Sumnua. De0e!opment of a bucca!
bioadhesi0e nicotine tab!et formu!ation for smo"in3 cessation. nternationa!
Lourna! of Pharmaceutics, $99)= 12%,127.
12. &a!um . Par", Da!e # Munday. De0e!opment and e0a!uation of a biphasic bucca!
adhesi0e tab!et for nicotine rep!acement therapy. nternationa! Lourna! of
Pharmaceutics, $99$= $1*,$$-.
13. Pao!o Giunchedi, &!audia Lu!iano, @!isabetta Ga0ini

, Massimo &ossu

, Mi!ena
Sorrenti

. @uropen Lourna! of Pharmaceutics and Biopharmaceutics, $99$= $%%,
$%8.
14. ;hmad Mahmood Mumta<, 6un3,Sen3 &hOn3 . @0a!uation of bioadhesi0e bucca!
tab!ets containin3 triamcino!one acetonide in hea!thy 0o!unteers. nternationa!
Lourna! of Pharmaceutica! Science, 188*= $)8,$*).
15. .a'esh Channa, SP ;3ar/a!, ;!"a ;hu'a. Preparation and e0a!uation of
bioerodib!e bucca! tab!ets containin3 c!otrima<o!e. nternationa! Lourna! of
Pharmaceutics, 188-= -2,2%.
ENCLOSURE0VI
45A Remar)s o& the #>i$e
+he present /or" is aimed to de0e!op and e0a!uate the Bucca! tab!et of
1ndansetron 6&!. 1ndansetron 6&! is a /ide!y used as anti emetic dru3. +he dru3 has a
shorter bio!o3ica! ha!f,!ife of about %,* hrs and its bioa0ai!abi!ity is on!y -9?. Sustained
1)
re!eased tab!et possib!y impro0e ora! bioa0ai!abi!ity of 1ndansetron 6&!. +he proposed
study can be carried out in the !aboratory.

Dr. C. C. Pati.
Professor P 6ead
.esearch Guide



1*