Practice Problems:

1. Synthroid 150 mcg intravenous is ordered daily. After reconstitution the vial contains a total
of 5 mL and there is 100 mcg/mL.
Give: _____________

2. Cefazolin sodium 250 mg IV every 8 hours. Reconstitute with 2.5 mL sterile normal saline.
After reconstitution the vial contains 225 mg/mL.
Give: ____________

3. Ampicillin 250 mg IM every 12 hours is ordered. After reconstitution there is 125 mg/mL.
Give: _____________

4. Cefazolin sodium 125 mg IV every 12 hours is ordered. After reconstitution the vial contains
225 mg/mL.
Give: __________

5. Ampicillin 350 mg IM is ordered daily. After reconstitution with 3.5 mL of sterile water, the
vial contains a total of 500 mg/mL.
Give: ___________




Practice Problems Answers:
1. 1.5 mL
2. 1.1 mL
3. 2 mL
4. 0.56 mL
5. 0.7 mL



Reconstitution Practice
1. Order: Prostaphlin 500 mg IM q6h
Label reads:
Prostaphlin
oxacillin sodium for injection
For IM use add 11.5 mL Sterile
Water for Injection U.S.P. Each
1.5 mL of solution contains 250 mg
oxacillin.
Give ________ mL








2. Order: Ticar 500 mg IM stat and q8h
Label reads:
Ticar
ticarcillin disodium
For IV or IM use. Add 12 mL
Sterile Water for Injection,
U.S.P.
or 1% Lidocaine HCl solution
(without
epinephrine). Each 2.5 mL of
solution
will then contain 1 g ticarcillin.
How many mL would be given?













3. Order: Ancef 225 mg IM q6h
Stock: on the shelf there are three vial sizes of powder: 250 mg, 500 mg, and 1g
RECONSTITUTION
Preparation of Parenteral Solution
For IM injection, IV direct (bolus) injection, or IV infusion, reconstitute
with Sterile Water for Injection according to the following table. SHAKE
WELL
Vial size Amt. diluent Approx. concentration Approx. available
volume
250 mg 2.0 mL 125 mg/mL 2.0 mL
500 mg 2.0 mL 225 mg/mL 2.2 mL
1 gram 2.5 mL 330 mg/mL 3.0 mL
Stock chosen: _________ Add _____ mL Give _____ mL
Stock chosen: _________ Add _____ mL Give _____ mL


4. Order: carbenicillin disodium 1 g IM q6h for an adult
Stock: vial of powder labeled 2 g
Use the following label for reconstitution.
For intramuscular use: The 2 g vial should be reconstituted with 4.0 mL of Sterile
Water for Injection, 0.5% Lidocaine Hydrochloride (without epinephrine), or
Bacteriostatic Water containing 0.9% benzyl alcohol. In order to facilitate
reconstitution up to 7.2 mL diluent can be used.
Amount of Diluent to be Volume to be Withdrawn for a
Added to the 2 g vial 1 g Dose
4.0 mL 2.5 mL
5.0 mL 3.0 mL
7.2 mL 4.0 mL
The 5 g vial should be reconstituted with 7.0 mL Sterile Water for Injection, 0.5%
Lidocaine Hydrochloride (without epinephrine), or Bacteriostatic Water containing
0.9% benzyl alcohol. In order to facilitate reconstitution up to 17 mL diluent can be
used.
Amount of Diluent to be Volume to be Withdrawn for a
Added to the 5 g vial 1 g dose
7.0 mL 2.0 mL
9.5 mL 2.5 mL
12.0 mL 3.0 mL
17.0 mL 4.0 mL
After reconstitution, no significant loss of potency occurs for up to 24 hours at room
temperature, and for 72 hours if refrigerated. Any of these unused solution should be
discarded.
a. Add _____ mL and give _____ mL
b. Add _____ mL and give _____ mL


Key for Reconstitution Problems
1. 3cc
2. 1.3cc
3. Stock chosen: 250 mg vial; add 2 mL Sterile Water for Injection; give 1.8 mL
Stock chosen: 500 mg vial; add 2 mL Sterile Water for Injection; give 1 mL
4a. Add 4 mL and give 2.5 mL
4b. Add 5 mL and give 3 mL