Professional Documents
Culture Documents
Support
o
ligaments: strong bands of fibrous connective tissue that attach to bones and hold them
together
Storage
o
calcium
phosphorus
fatty tissue
Hemopoiesis:
Protection
Movement
o
tendons: strong bands of connective tissue that attaches skeletal muscles to bones
Leverage
Cartilage
3 types:
hyaline
fibrocartilage
elastic
endochondral ossification:
also involved in bone growth and repair
Structure of Hyaline
specialized cells
chondroblast: cartilage producing cells; synthesize matrix
chondrocyte: mature cartilage cell; when matrix surrounds a chondroblast; round cell that
occupies a space called a lacuna; maintain matrix
lacuna: small space or cavity; potential space within the matrix of bone or cartilage normally
occupied by a cell that can be visualized only when the cell shrinks away from the matrix during fixation;
tissue is avascular
this is why it takes longer to repair damaged tissue
surrounded by the perichondrium
spongy: open network of struts and plates, usually found on the interior of the bone
Bone Histology
Bone: is a connective tissue that is composed of specialized cells in a mineralized matrix
classified based on organization of collagen fiber
Matrix:
nonliving component
Specialized Cells:
osteoprogenitor cells:
o
skin cells
osteoblasts:
o
produce matrix
osteocytes:
o
found in lacunae
osteoclasts:
o
large cells that release acid to break down matrix which releases calcium
Osseous Tissue:
Compact Bone:
central canal containing blood capillaries and the concentric lamellae around it
osteocytes are found in the lacunae, sandwiched between layers of osseous tissue
perforating canals enter the bone and provide passageways for blood vessels
nutrients reach cells through canaliculi that open onto the surface of the trabeculae
Bone classification
yellow marrow: fat stored within the medullary cavity or in the spaces of spongey bone
red marrow: connective tissue in the spaces of spongy bone or in the medullary cavity; site of
hemopoiesis
5.
Periosteum: superficial layer of bone, isolates bone from surrounding tissue, actively participates
in bone growth
double layered connective tissue membrane covering the outer surface of bone except where
articular cartilage is present
blood vessels and nerves from the periosteum supply the bone
4.
Endosteum: lines the marrow cavity, active during bone growth or repair
5.
Articular Cartilage: thin layer of hyaline cartilage covering a bone where it forms a joint
(articulation) with another bone
6.
Perforating fibers: bundles of collagen fibers that strengthen the attachment of tendons or
ligaments to the bone
Calcification:
calcium crystals are deposited within the tissue
Ossification:
no stage is comparable
2.
chondrocyte hypertrophy, the cartilage matrix becomes calcified, and the chondrocytes die
the perichondrium becomes the periosteum when osteochondral progenitor cells within the
periosteum become osteoblasts
blood vessels and osteoblasts form the periosteum invade the calcified cartilage template;
internally, these osteoblasts form spongy bone at primary ossification centers (and later at
secondary ossification centers); externally, the periosteal osteoblasts form compact bone
1. Mesenchymal cells cluster together and begin to secrete the organic components of the matrix.
2. Mesenchymal cells differentiate into osteoblasts. Some become trapped in bony pockets and
mature into osteocytes.
3. Bone grows outward in small projections. Interconnection of projections traps blood vessels.
4. Mesenchymal cells divide and produce more osteoblasts.
5. Remodeling around blood vessels forms osteons.
6. Fibrous connective tissue around the bone becomes organized into periosteum.
Process of Endochondral ossification
periosteal cells: differentiate into osteoblasts and produce more layers of bony matrix
appositional growth:chondroblasts in the perichondrium add new cartilage to the outside edge of
the existing cardilage
new layers of osseous tissue are added to the outer layer of the bone
osteoblasts beneath the periosteum lay down bone to form ridges separated by grooves. blood
vessels of the periosteum lie in the grooves.
2.
the groove is transformed into a tunnel when the bone built on adjacent ridges meets. the
periosteum of the groove becomes the endosteum of the tunnel
3.
appositional growth by osteoblasts from the endosteum results in the formation of a new
concentric lamella
4.
the production of additional concentric lamellae fills in the tunnel and completes the formation of
the osteon
At the junction between the diaphysis and epiphysis: epiphyseal plate-composed of cartilage
More cartilage is produced on the epiphyseal side of the epiphyseal plate as ossification occurs
on the diaphysis side
As long as the rate of new cartilage production = the rate of ossification, the bone will grow in
length.
At puberty, rising levels of sex hormones, growth hormones and thyroid hormones increases the
rate of ossification.
When the epiphyseal plate is reduced to a line, growth in length will stop
2.
Zone of proliferation
a. new cartilage is produced on the epiphyseal side of the plate as the chondrocytes divide and form
stacks of cells
3.
Zone of hypertrophy
a. chondrocytes mature and enlarge
4.
Zone of calcification
a. matrix is calcified, and chondrocytes die
5.
Ossified bone
a. the calcified cartilage on the diaphyseal side of the plate is replace by bone
vitamin D
vitamin C
o
hormones
o
growth hormone: increases general tissue growth including overall bone growth, by
stimulating interstitial cartilage growth and appositional bone growth
thyroid hormone: required for normal growth of all tissues, including cartilage; decrease in
hormone results in smaller individual.
sex hormones: influence bone growth: estrogen and testosterone initially stimulate bone
growth, which accounts for the burst of growth at puberty, when production of these
hormones increase.
storage in bones
Parathyroid Hormone (PTH): released by the parathyroid when levels of calcium are low;
stimulates osteoclast activity, indirectly increases rate absorption at the intestines, decrease rate
of excretion at kidneys
Calcitonin: released by the thyroid when calcium levels are high; inhibits osteoclasts activity,
increase rate of excretion at kidneys
Calcium Homeostasis
1.
2.
3.
PTH individually stimulates osteoclasts to break down bone and release Ca2+ into the blood.
Calcitonin inhibits osteoclasts. Osteoblasts remove Ca2+ from the blood to make bone.
In the kidneys, PTH increases Ca2+ reabsorption from the urine.
In the kidneys, PTH also promotes the formation of active vitamin D, which increases Ca2+
reabsorption form the small intestines.