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Background: Glaucoma and diabetes mellitus both diseases have now emerged as
the leading causes of irreversible blindness. Potential association between diabetes
mellitus and primary open angle glaucoma has been a subject of much debate and
results from various studies and publications have both confirmed and denied this
positive correlation. Since the burden of blindness from both these diseases on the
patients and society is expected to increase due to increase in population, longevity
and alarming rise in incidence of DM, it is important to know if a significant association
exists between them.
Aims: Purpose of the study was to find any positive correlation between DM and
POAG.
Design: Prospective cross sectional random analysis
Material And Methods: Present study was done on 500 confirmed diabetics and 300
confirmed POAG patients who were evaluated for presence of POAG and prevalence
of DM respectively and compared with 300 age matched healthy subjects. Blood
sugar estimation, applanation tonometry, automated perimetry and optic nerve
head evaluation were done for assessment of diabetetic status and glaucoma. POAG
was defined on the basis of glaucomatous visual field defects matching disc changes.
Results: Incidence of primary open angle glaucoma was 9.3 % in diabetics compared
to 7% in control group, and 10% of POAG patients had DM against 7.3% in controls.
Number of subjects having ocular hyper tension was higher in diabetes (4%) than
control group (1%).
Conclusion: In our study no significant association could be established between
diabetes mellitus and primary open angle glaucoma.
Key Words: Primary open angle glaucoma (POAG), Diabetes mellitus (DM), Disc
changes, IOP.
Introduction:
Primary open angle glaucoma (POAG)
is a chronic, bilateral often asymmetric
progressive
optic
neuropathy,
characterized by morphological changes
at optic nerve head (ONH) and retinal
nerve fibre layer with/without raised
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National Journal of Medical and Dental Research, July-September 2014: Volume-2, Issue-4, Page 15-19
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National Journal of Medical and Dental Research, July-September 2014: Volume-2, Issue-4, Page 15-19
Confirmation of glaucoma:
POAG was diagnosed on the basis of glaucomatous visual
field defects, matching disc changes (without any other
abnormality that could have caused the visual field defect)
regardless of IOP with open angle of anterior chamber.
Patients with IOP >22 mm of Hg without evidence of ONH
changes and field changes typical of POAG were labelled
as having Ocular Hypertension.
Diagnosis of diabetes:
DM was confirmed either by a positive history of previously
diagnosed / treated diabetes (on record) or by post prandial
blood glucose level >140 mg%.
Observations:
Table 1: Demographic profile of study population
AGE(in years)
DM
POAG
CONTROL
40 49
50 59
60 69
>70
Total
SEX
Male
Female
Total
52
212
170
66
500
264
236
500
14
56
134
96
300
132
168
300
54
108
90
48
300
135
165
300
DMn=250
26 %(130)
54%(162)
16 22
62 %(310)
38%(114)
>22
12 %(60)
8%(24)
Total
100 %(500)
100%(300)
POAG .(n=300)
CONTROL (n=300)
6.6% (20)
6% (18)
GTT (Positive)
2.6% (08)
2% (06)
TOTAL
9.3% (28)
8% (24)
DIABETIC Group
(n=500)
CONTROL Group
(n=300)
Definite Glaucoma
10% (50)
7.6% (23)
Ocular Hypertension
4% (20)
1% (3)
CONTROLn=100
<16
Discussion:
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National Journal of Medical and Dental Research, July-September 2014: Volume-2, Issue-4, Page 15-19
Conclusion:
The prevalence of both diabetes mellitus and primary open
angle glaucoma is increasing and the diagnosed cases
represent the tip of iceberg only. The association between
both these diseases has been recognized for many years but
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National Journal of Medical and Dental Research, July-September 2014: Volume-2, Issue-4, Page 15-19
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