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20
concept that conversion of T4 to T~ depends upon a 5'monodeiodinase enzyme system that is immature at
birth? The 3,3'T2 is thought to be derived at least in part
from the peripheral conversion of T~ and reverse T~? In
this infant, the 3,3'T~ level was high at birth, and
remained elevated until the twenty-sixth day; therefore, it
seems likely that the enzyme or enzymes capable of
forming 3,3'T~ in thyrotoxicosis are operative at birth.
LATS-P was present in high concentrations-in the
serum of both mother and infant, whereas LATS was
measurable in both at low levels which could be considered nonspecific? The high concentration of LATS-P in
the infant's serum when he was hyperthyroid and its
reduction to undetectable levels when he became euthy-.
roid suggest a role for this thyroid-stimulating immunoglobulin in the development of neonatal thyrotoxic0sis?
Although the routine measurement, in all pregnant
thyr0toxic women, of the thyroid-stimulating immunoglob.ulins LATS and LATS-P may be helpful in detecting
neofmtal thyrotoxicosis, a definitive diagnosis of this
disorder requires the demonstration of elevated iodothyronines in the infant. Although T4 and rT3 levels in cord
serum are normally higher than in serum of euthyroid
adults, ~"~ markedly elevated levels should suggest hyperthyroidism. A n elevated cord serum T3 value may be
diagnostic, since it is normally very low, ~. s and an
elevated cord serum 3,3'T: level also indicates overproduction of iodothyronines.
This patient illustrates that a variety of iodothyronines
are abnormally elevated in neonatal thyrotoxicosis,
and supports the concept that the disorder is produced by
transplacental transmission of thyroid-stimulating immunoglobulins.
We thank Dr. David II. Solomon for his valuable advice as
well as his help in performing the LATS and LATS-protector
Vol,,me 93
Number I
12 1
VARIAB LES
Nipple formation
S
IIipple barely
v.[slble: no /
areola "/ ~
;/ell-def.[ned
Areola stlppled |
nipple : areola~ not raised
A
Thin,
gelatinous
Thin
<0.Ts/~,~
>
0.75 en
Areola
raised
>0.75
t:
B?
Skin texture
A
S
O
M
A
T
I
C
/
C
Ear form
A
:1
D
II
E
U
R
O
L
O
G
I
C
A
L
and
smooth
K=
Breast size
204
days
Plantar creases
llo breast
t.[ssue
S
/
I;o creases
Smooth, medium
thlekness,superf.[clal peeling
~i0
Incurving of
part of edge
Partial incurvlng
of whole of upper
pinna
/
Diameter
Diameter
0.5 - 1 on
<0.5 cm /
/i0
Faint
red
marks
over
anterior~. '.
Definite red m a r k s
over anterior 1/2,
anteri~176
over/
/20
Nell-deflned
incurvlngof
pinna
/
Diameter
> 1 on
/
/is
Indentations
over anterlor
1/2
/~/
Deep indentations
over more than
anterior 1/2W./~Q
K=
200
days
Fig.I. Variables and assigned scores in ihe modified Dubowitz method for assessment of gestational age. A. Gestational
age in days = 204 + total somatic score (for neurologically depressed infants). B, Gestational age in days = 200 + total
combined somatic and neurologic score (for healthy infants).
rice, in vie`,',' of the large n u m b e r of Variables to be
considered. Our aim has been to simplify this method,
reducing the n u m b e r of variables while keeping reasonable precision.
Abbreviation used
GA:
gestational age
MATERIAL
AND METHOD
122
OF
breast size, 10; plantar creases, 15; scarfsign, 12; head lag,
8; K, 200 = 284 days.
DISCUSSION
The Dubowitz method with 21 variables is somewhat
impractical for daily practice. Some authors '~": have tried
to simplify it in order to make it easier and quicker for the
clinician and the infant, yet preserving its original precision.
Our simplified method with only six variables has a
similar correlation coefficient and error as that by Dubowitz. Moreover, it can be used even when the infant is
neurologically depressed.
REFERENCES
1. Farr V, and Mitchell RG: Estimation of gestational age in
the newborn infant. Comparison between birth weight and
maturity scoring in infants premature by weight, Am J
Obstet Gynecol 103:380, 1969.
2. Usher R, McLean F. and Scott KE: Judgment Of fetal age.
li. Clinical importance of gestational age and an objective
method to value it, Pediatr Clin North Am, 835, 1966..
3. Saint-Anne D'Argassies S: La maturation neurologique du
pr6mature, Etud N6o-Natales 4:71, 1955.
4. Amiel-Tison C: Neurological evaluation of the maturity of
newborn infants, Arch Dis Child 43:89, 1968.
5. Dubowitz LMS, Dubowitz V, and Goldberg C: Clinical
assessment of gestational age in the newborn infant, J
PEDtA'rR 77:1, 1970.
6. Parkin JM, Hey EN, and Clowes JS: Rapid assessment of
gcstational age at birth, Arch Dis Child 51:259, 1976.
7. Bailard: Mentioned in Klaus MH, and Fanaroff AA,
editors: "Care of the high-risk neonate", Philadelphia. 1973,
WB Saunders Company, p 47.
OJ:
orojejunal
CASE R E P O R T
From the Department of Neonatolog), RadiologL and
Pediatrics, Janws IVhitcomb Rile)' ttospital for
Children, Indiana University Medical Center.
*Reprint adress: Rile)' Children's Hospital Department of
Radiology, 1100 West Michigan St. Indianapolis, IN 46202.
A one-hour-old, 936-gram boy was admitted to Riley Children's Hospital for mild respirator), distress complicated by
episodes of apnea and brady-cardia. To maintain nutritional
status a No. 5 Frencfi orojejunal tube made of polyvinyl chloride
0022-3476/78/0193-0122500.30/0 9 1978 The C. V. Mosby Co.