Ankylosing Spondylitis Therapeutics - Pipeline

Assessment and Market Forecasts to 2019

On 21st November 2014

Summary
The industry analysis specialist, has released its new report, Ankylosing Spondylitis
Therapeutics - Pipeline Assessment and Market Forecasts to 2019. The report is an essential
source of information and analysis on the global Ankylosing Spondylitis Therapeutics market.
The report identifies the key trends shaping and driving the global Ankylosing Spondylitis
Therapeutics market. The report also provides insights on the prevalent competitive landscape
and the emerging players expected to significantly alter the market positioning of the current
market leaders. Most importantly, the report provides valuable insights on the pipeline
products within the global Ankylosing Spondylitis Therapeutics sector. This report is built using
data and information sourced from proprietary databases, primary and secondary research and
in-house analysis by GlobalDatas team of industry experts.

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Scope
The report provides information on the key drivers and challenges of the Ankylosing Spondylitis
Therapeutics market. Its scope includes - Annualized seven key markets (US, France, Germany, Italy, Spain, UK and Japan) Ankylosing
Spondylitis Therapeutics market revenues data from 2006 to 2011, forecast for eight years to
2019.
- Pipeline analysis data providing a split across the different phases, mechanisms of action being
developed and emerging trends by seven key markets. Pipeline candidates fall under major
therapeutic classes.
- Analysis of the current and future competition in the seven key countries Ankylosing
Spondylitis Therapeutics market.
- Insightful review of the key industry drivers, restraints and challenges. Each trend is
independently researched to provide a qualitative analysis of its implications.
- Key topics covered include strategic competitor assessment, market characterization, unmet
needs and the implications for the Ankylosing Spondylitis Therapeutics market.
- Analysis of key recent licensing and partnership agreements in Ankylosing Spondylitis
Therapeutics market

Reasons to buy
The report will enhance your decision making capability. It will allow you to - Develop and design your in-licensing and out-licensing strategies through a review of pipeline
products and technologies and by identifying the companies with the most robust pipeline.
- Develop business strategies by understanding the trends shaping and driving the global
Ankylosing Spondylitis Therapeutics market.
- Drive revenues by understanding the key trends, innovative products and technologies,
market segments and companies likely to impact the global Ankylosing Spondylitis Therapeutics
market in future.
- Formulate effective sales and marketing strategies by understanding the competitive
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landscape and by analyzing the performance of various competitors.

- Identify emerging players with potentially strong product portfolios and create effective
counter-strategies to gain a competitive advantage.
- Organize your sales and marketing efforts by identifying the market categories and segments
that present maximum opportunities for consolidations, investments and strategic
partnerships.
- Whats the next big thing in the global Ankylosing Spondylitis Therapeutics market landscape?
Identify, understand and capitalize.

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Table of Content
2 Ankylosing Spondylitis Therapeutics - Introduction 7
2.1 Disease Overview 7
2.2 Epidemiology 7
2.2.1 Prevalence 7
2.2.2 Ethnicity 8
2.2.3 Gender 8
2.2.4 Quality of Life Parameters 9
2.2.5 Socioeconomic Impact 9
2.2.6 Mortality and Morbidity 9
2.3 Etiology and Pathology 9
2.4 Signs and Symptoms 10
2.5 Diagnosis 10
2.5.1 Patient History 10
2.5.2 Physical Examination 10
2.5.3 Laboratory Tests 11
2.5.4 Imaging Tests 11
2.5.5 Modified New York Criteria 12
2.6 Treatment and Management Options 12
2.6.1 Medications 12
2.6.2 Exercise and Physiotherapy 15
2.6.3 Surgery 15
2.7 Referral Pathway 15
2.8 GlobalData Pipeline Report Guidance 16
3 Ankylosing Spondylitis Therapeutics - Market Characterization 17
3.1 Overview 17
3.2 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - Global 17
3.3 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - Global 18
3.4 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - The US 19
3.5 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - The US 20
3.6 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - France 21
3.7 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - France 22
3.8 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - Germany 23
3.9 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - Germany 24
3.10 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - Italy 25
3.11 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - Italy 26
3.12 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - Spain 27
3.13 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - Spain 28
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3.14 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - The UK 29

3.15 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - The UK 30
3.16 Ankylosing Spondylitis Therapeutics Market Size (2006-2011) - Japan 31
3.17 Ankylosing Spondylitis Therapeutics Market Forecast (2011-2019) - Japan 32
3.18 Drivers and Barriers for the Ankylosing Spondylitis Therapeutics Market 33
3.18.1 Drivers for the Ankylosing Spondylitis Therapeutics Market 33
3.18.2 Barriers for the Ankylosing Spondylitis Therapeutics Market 33
3.19 Opportunity and Unmet Need Analysis 34
3.20 Key Takeaway 34
4 Ankylosing Spondylitis Therapeutics - Competitive Assessment 35
4.1 Overview 35
4.2 Strategic Competitor Assessment 35
4.3 Product Profiles for the Major Marketed Products in the Ankylosing Spondylitis Market 36
4.3.1 Celebrex (celecoxib) 36
4.3.2 Arcoxia (etoricoxib) 37
4.3.3 Enbrel (etanercept) 38
4.3.4 Humira (adalimumab) 39
4.3.5 Remicade (infliximab) 41
4.3.6 Simponi (golimumab) 43
4.4 Key Takeaway 45
5 Ankylosing Spondylitis Therapeutics - Pipeline Assessment 46
5.1 Overview 46
5.2 Strategic Pipeline Assessment 46
5.3 Ankylosing Spondylitis Therapeutics Pipeline - Pipeline by Phases of Development 46
5.3.1 Ankylosing Spondylitis Therapeutics - Phase III Pipeline 47
5.3.2 Ankylosing Spondylitis Therapeutics - Phase II Pipeline 47
5.3.3 Ankylosing Spondylitis Therapeutics - Phase I Pipeline 47
5.3.4 Ankylosing Spondylitis Market - Pre-Clinical Pipeline 48
5.4 Ankylosing Spondylitis Therapeutics Market - Pipeline by Mechanism of Action 48
5.5 Technology Trends Analytic Framework 49
5.6 Ankylosing Spondylitis Therapeutics - Promising Drugs Under Development 50
5.7 Molecule Profile for Promising Drugs under Development 50
5.7.1 AIN457 (secukinumab) 50
5.7.2 Cimzia (certolizumab pegol) 51
5.8 Key Takeaway 51
6 Ankylosing Spondylitis Therapeutics - Clinical Trials Mapping 52
6.1 Clinical Trials by Region/Country (the US, EU5 and Japan) 52
6.2 Clinical Trials by Phase 53
6.3 Clinical Trials by Trial Status 54
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6.4 Prominent Sponsors 55

6.5 Top Companies Participating in Ankylosing Spondylitis Therapeutics Clinical Trials 57
7 Ankylosing Spondylitis Therapeutics - Strategic Assessment 58
7.1 Key Events Impacting the Future Market 58
7.2 Ankylosing Spondylitis Therapeutics: Implications for Future Market Competition 59
8 Ankylosing Spondylitis Therapeutics - Future Players 60
8.1 Introduction 60
8.2 Company Profiles 60
8.2.1 Novartis 60
8.2.2 UCB 63
9 Licensing and Partnership Deals 64
10 Ankylosing Spondylitis Therapeutics - Appendix 65
10.1 Market Definitions 65
10.2 Abbreviations 65
10.3 Methodology 66
10.3.1 Coverage 66
10.3.2 Secondary Research 67
10.3.3 Forecasting 67
10.3.4 Primary Research 69
10.3.5 Expert Panel Validation 70
10.4 Contact Us 70
10.5 Disclaimer 70
10.6 Bibliography 70

List Of Tables
Table 1: Prevalence of Ankylosing Spondylitis in Different Ethnic Groups and Regions 8
Table 2: Ankylosing Spondylitis Therapeutics Market, Global, Revenue ($m), 2006-2011 17
Table 3: Ankylosing Spondylitis Therapeutics Market, Global, Forecast ($m), 2011-2019 18
Table 4: Ankylosing Spondylitis Therapeutics Market, The US, Revenue ($m), 2006-2011 19
Table 5: Ankylosing Spondylitis Therapeutics Market, The US, Forecast ($m), 2011-2019 20
Table 6: Ankylosing Spondylitis Therapeutics Market, France, Revenue ($m), 2006-2011 21
Table 7: Ankylosing Spondylitis Therapeutics Market, France, Forecast ($m), 2011-2019 22
Table 8: Ankylosing Spondylitis Therapeutics Market, Germany, Revenue ($m), 2006-2011 23
Table 9: Ankylosing Spondylitis Therapeutics Market, Germany, Forecast ($m), 2011-2019 24
Table 10: Ankylosing Spondylitis Therapeutics Market, Italy, Revenue ($m), 2006-2011 25
Table 11: Ankylosing Spondylitis Therapeutics Market, Italy, Forecast ($m), 2011-2019 26
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Table 12: Ankylosing Spondylitis Therapeutics Market, Spain, Revenue ($m), 2006-2011 27
Table 13: Ankylosing Spondylitis Therapeutics Market, Spain, Forecast ($m), 2011-2019 28
Table 14: Ankylosing Spondylitis Therapeutics Market, The UK, Revenue ($m), 2006-2011 29
Table 15: Ankylosing Spondylitis Therapeutics Market, The UK, Forecast ($m), 2011-2019 30
Table 16: Ankylosing Spondylitis Therapeutics Market, Japan, Revenue ($m), 2006-2011 31
Table 17: Ankylosing Spondylitis Therapeutics Market, Japan, Forecast ($m), 2011-2019 32
Table 18: Components of Ankylosing Spondylitis Disease Activity 38
Table 19: Components of Ankylosing Spondylitis Disease Activity 40
Table 20: Components of Ankylosing Spondylitis Disease Activity 42
Table 21: Proportion of ASAS Responders at Weeks 14 and 24 43
Table 22: Median Percent Improvement in ASAS Components AT Week 14 44
Table 23: Ankylosing Spondylitis Therapeutics, Phase III Pipeline, 2011 47
Table 24: Ankylosing Spondylitis Therapeutics, Phase II Pipeline, 2011 47
Table 25: Ankylosing Spondylitis Therapeutics, Phase I Pipeline, 2011 47
Table 26: Ankylosing Spondylitis Therapeutics, Pre-Clinical Pipeline, 2011 48
Table 27: Ankylosing Spondylitis Therapeutics - Most Promising Drugs Under Development,
2011 50
Table 28: Ankylosing Spondylitis Therapeutics, Clinical Trials by Country, 2011 52
Table 29: Ankylosing Spondylitis Therapeutics, Clinical Trials by Phase, 2011 53
Table 30: Ankylosing Spondylitis Therapeutics, Clinical Trials by Status of Development, 2011 54
Table 31: Ankylosing Spondylitis Therapeutics, Prominent Sponsors, 2011 56
Table 32: Ankylosing Spondylitis Therapeutics, Top Companies Participating in Therapeutics
Clinical Trials, 2011 57
Table 33: Novartis - Inflammation and Immunology Pipeline, 2011 62
Table 34: Novartis - Ankylosing Spondylitis Pipeline, 2011 62
Table 35: UCB - Immunology Pipeline, 2011 63
Table 36: UCB- Ankylosing Spondylitis Pipeline, 2011 63
Table 37: Ankylosing Spondylitis Therapeutics, Global, Deals, 2009-2011 64

List Of Figures
Figure 1: Ankylosing Spondylitis 7
Figure 2: Pathogenesis of Ankylosing Spondylitis 10
Figure 3: Modified New York Criteria 12
Figure 4: Comparisons of NSAIDs 13
Figure 5: Comparisons of DMARDs 13
Figure 6: Comparisons of Corticosteroids 14
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Figure 7: Comparisons of Biologics 14

Figure 8: Ankylosing Spondylitis Therapeutics - Referral Pathway 15
Figure 9: Ankylosing Spondylitis Therapeutics Market, Global, Revenue ($m), 2006-2011 17
Figure 10: Ankylosing Spondylitis Therapeutics Market, Global, Forecast ($m), 2011-2019 18
Figure 11: Ankylosing Spondylitis Therapeutics Market, The US, Revenue ($m), 2006-2011 19
Figure 12: Ankylosing Spondylitis Therapeutics Market, The US, Forecast ($m), 2011-2019 20
Figure 13: Ankylosing Spondylitis Therapeutics Market, France, Revenue ($m), 2006-2011 21
Figure 14: Ankylosing Spondylitis Therapeutics Market, France, Forecast ($m), 2011-2019 22
Figure 15: Ankylosing Spondylitis Therapeutics Market, Germany, Revenue ($m), 2006-2011 23
Figure 16: Ankylosing Spondylitis Therapeutics Market, Germany, Forecast ($m), 2011-2019 24
Figure 17: Ankylosing Spondylitis Therapeutics Market, Italy, Revenue ($m), 2006-2011 25
Figure 18: Ankylosing Spondylitis Therapeutics Market, Italy, Forecast ($m), 2011-2019 26
Figure 19: Ankylosing Spondylitis Therapeutics Market, Spain, Revenue ($m), 2006-2011 27
Figure 20: Ankylosing Spondylitis Therapeutics Market, Spain, Forecast ($m), 2011-2019 28
Figure 21: Ankylosing Spondylitis Therapeutics Market, The UK, Revenue ($m), 2006-2011 29
Figure 22: Ankylosing Spondylitis Therapeutics Market, The UK, Forecast ($m), 2011-2019 30
Figure 23: Ankylosing Spondylitis Therapeutics Market, Japan, Revenue ($m), 2006-2011 31
Figure 24: Ankylosing Spondylitis Therapeutics Market, Japan, Forecast ($m), 2011-2019 32
Figure 25: Opportunity and Unmet Need in the Ankylosing Spondylitis Therapeutics Market,
2011 34
Figure 26: Ankylosing Spondylitis Therapeutics, Strategic Competitor Assessment, 2011 36
Figure 27: Ankylosing Spondylitis Therapeutics - Pipeline by Phase of Development, 2011 46
Figure 28: Ankylosing Spondylitis Therapeutics, Pipeline by Mechanism of Action (%), 2011 48
Figure 29: Ankylosing Spondylitis Therapeutics, Technology Trends Analytics Framework, 2011
49
Figure 30: Ankylosing Spondylitis Therapeutics, Technology Trends Analytics Framework,
Description, 2011 50
Figure 31: Ankylosing Spondylitis Therapeutics, Clinical Trials by Country, 2011 52
Figure 32: Ankylosing Spondylitis Therapeutics, Clinical Trials by Phase (%), 2011 53
Figure 33: Ankylosing Spondylitis Therapeutics, Clinical Trials by Status of Development (%),
2011 54
Figure 34: Ankylosing Spondylitis Therapeutics, Overall Sponsors (%), 2011 55
Figure 35: Ankylosing Spondylitis Therapeutics, Prominent Sponsors (%), 2011 56
Figure 36: Ankylosing Spondylitis Therapeutics, Top Companies Participating in Clinical Trials,
2011 57
Figure 37: Ankylosing Spondylitis Therapeutics Market, Drivers and Restraints, 2011 58
Figure 38: Implications for Future Market Competition in the Ankylosing Spondylitis Market,
2011 59
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Figure 39: Ankylosing Spondylitis Therapeutics Market, Pipeline by Company, 2011 60

Figure 40: GlobalData Market Forecasting Model 69

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