Professional Documents
Culture Documents
Outline
] Overview of GI Tract
] Movement of GI Tract
] Nutritional requirements
] Exocrine GI secretions
] Digestion, absorption, assimilation
] Endocrine control
Overview of GI tract
] Receiving
] Conducting, storing
] Digestion, absorption
] absorbing water, defecating
The Pharynx- receiving
Chief cells:
pepsinogen
(converted to
active
enzyme,
pepsin)
Small intestine- digestion
and absorption
] Receives secretory products from pancreas, liver
(via gallbladder)
] most absorption of nutrients and water takes
place here
] mostly alkaline digestion of proteins, fats,
carbos, because bicarbonate (HCO-3 from
pancreas) neutralizes stomach acid
Small intestine- digestion
and absorption
] PSNS stimulates
] SNS inhibits. Exception- irritable bowel
syndrome- SNS stimulates movement of
colon
] hormonal control
\ gastrin(stomach)- stimulates motility
\ secretin (duodenum) inhibits motility
Cellular basis for motility
] Smooth muscle throughout GI tract
] GI smooth muscle is myogenic- contracts 12-3
times per minute
] GI smooth muscle acts as a functional
syncytium- nexus or gap junctions connect
muscle cells
] neuronal and hormonal cues are not required
for contraction, but are important for changing
rate of contraction
Nutritional Requirements
Figure 4.1 The composition of the adult human
body
Figure 4.2 Amino acid
chemistry (Part 1)
Figure 4.2 Amino acid chemistry (Part 2)
Aminoacids
Glycine Alanine Serine Threonine Cysteine Proline Valine
] Salivary glands
] Stomach
] Pancreas
] Liver and gall bladder
] Small intestine
Stomach
] Chief cells
\ Pepsinogen (inactive) converted to pepsin
(active) form of a proteolytic enzyme.
] Parietal cells
\ Intrinsic factor- required for vitamin B12
absorption
\ Hydrochloric acid
] Mucous cells
Small intestine
] Endoproteases
] Cleave internal peptide bonds
] Trypsin- trypsinogen converted to trypsin by
enterokinase. Attacks on carboxyl side of
arginine or lysine.
] Chymotrypsin- chymotrypsinogen converted to
chymotrypsin in small intestine by trypsin.
Attacks on carboxyl side of tyrosine,
phenylalanine, tryptophan, leucine or
methionine.
Pancreatic secretions
(con’t)
Glut- facilitated
diffusion
transporter
GLUT family of proteins
Glut 1 Brain, RBC High affinity
glucose transport
Glut 2 Small intestine Low affinity
glucose transport
Apo
VLDL
B
LDL
Apo
B
Apo
B
Ap
o
B
Apo
o C B
Ap
oC Ap
Ap o
A
HDL
Apo
A
C
Apo
o
Albumin
Ap
A
ApoC
Ap
B o
B o
Ap
ApoC
Apo
A
CHYLO
Apo
Apo
B
Apo
A C
Apo o
Ap
A
] Phases of digestion.
] Cephalic phase-sensory input from food.
] Gastric phase-food enters stomach.
] Intestinal phase-chyme enters duodenum.
Cephalic phase
+ Parietal HCl
-
Sensory stimuli
cell +
+
+ ECL
cell Histamine
Vagus ACh
nerve +
+ G cell
Gastrin
- D cell Somatostatin
(SS)
ECL, enterochromaffin-like cell
Gastric hormones
Cephalic phase
Brain stem
gastric phase
Stomach
distention
Vagus
nerve
Acid
secretion
Stomach gastrin
Intestinal phase
] Acid-rebound theory
\ Acid and mucous production shuts down during
stress. When recovery occurs, acid starts before
mucous production.
] Acid secretion hypothesis
] Bacterial hypothesis
\ Stress decreases immune system function, allows for
an increase in stomach bacteria, specifically
Helicobacter pylori, a bacterium that has been
associated with ulcer formation.