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HemeOnc - Anatomy
Polycythemia or (Erythrocytosis):
Disease state defined as increased hematocrit.
Anisocytosis = RBCs of varying sizes
Poikilocytosis = RBCs of varying shapes
Life span of RBC = 120 days
Approximately 13 of platelet pool is stored in the spleen.
NORMAL WBC differential from highest to lowest:
Neutrophils (5462%)
Lymphocytes (2533%)
Monocytes (37%)
Eosinophils (13%)
Basophils (00.75%)
What are the 3 granulocytes?
Blood smear shows Hypersegmented neutrophils ("polys"):
Think...
Probable Diagnosis: (2)
Band cells are immature neutrophils.
Answers
Notes
Monocyte
NAACP
- Neoplasia
- Asthma
- Allergic reactions
- Connective Tissue Disorders
- Parasites (invasive)
Eosinophils
- CD19
- CD20
CD28
*80%
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Questions
140820.3 Chemotherapy
Hemorrhagic Cystitis is caused by an accumulation of
Acrolein.
Answers
Notes
- Vigorous hydration
- MESNA (mercaptoethane sodium)
*MESNA must be given before chemo treatment
- Cyclophosphamide > 1g/m2/dose
- Ifosfamide (any dose)
Binds acrolein (uroprotectant)
- Alkylating agents
Myelosuppression
- Nephrotoxic, but renally cleared
---Positive feedback cycle
- Patient must have good renal function
Carboplatin