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Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid Levels in Type 2 Diabetic Subjects
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2012 Basavaraj S. Aski, B. B. Devarnavadagi, G. Rudrappa & R. T. Kashinath. This is a research/review paper, distributed
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I.
Introduction
II.
Year 2012
Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid
Levels in Type 2 Diabetic Subjects
Year 2012
2
10
III.
Results
IV.
Discussion
11
Year 2012
Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid
Levels in Type 2 Diabetic Subjects
Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid
Levels in Type 2 Diabetic Subjects
6.
7.
Year 2012
8.
12
2
9.
10.
11.
12.
13.
14.
15.
16.
ISSN 0975-3923
Sciences, 2010, 2 (1): 15-23.
Indexed With Index Copernicus.
Richard Henary etal (1974) in Clinical Chemistry
Principle and Practice 2nd edition. Row publishers
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Choudhary K, (1989) in Biochemical Techniques,
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Richard, J. Henry et al 1974a, Clinical chemistry
principles and practice 2nd edn. Herper row
publishers New York, Chapter-28, lipids, 14381441.
Herbert K, Lipid. Clinical chemistry: Theory,
Analysis, correlation. (Editor) A. kaplan, Amadeo JP,
Stevenc Kazmierczak. 4th Edition 2003 Mosby.
1182-1230.
Grove TH. Effect of reagent pH on determination of
high density lipoprotein cholesterolby precipitation
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Nath R L 1990, c. Practical Biochemistry in clinical
medicine 2nd edn. Academic Publisher Calcutta
fattyacid page.
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medicine 2nd edn. Academic Publisher Calcutta
page 112-141.
Dang Aq, Fass FH, and Corter W. J. -lipids 1984:
19: 738- 748.
Locke, S. and Tarsy, D. (1985). The nervous system
and diabetes in Joslins diabetes mellitus. K.M.
Varghese Company (India), 12th Edition, pp664685.
UKDDS Group, UK prospective diabetes study 27:
plasma lipid and lipo proteins at diagnosis of
NIDDM by age and sex. Diabetic care, 1997; 20:
1683-1687.
World Health Organization; Diabetes mellitus; 1985.
Report of WHO study group, Geneva, World Health
Organization, Technical Report Series Na. 727.
Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid
Levels in Type 2 Diabetic Subjects
Table : 1
Parameters
Fasting plasma Glucose
mg/dl
85.54
13.65
156.20
35.31***
126.58
22.32
705.62
128.80
1348.96
103.58***
1114.28
92.50
108.95
20.14
16.62
3.18
166.51
8.28
235.29
31.66***
23.31
3.16***
205.59
7.68***
228.51
18.80
24.12
4.10
194.60
7.28
Triacylglycerol mg/dl
Total Phopholipids mg/dl
Total Fatty Acids mg/dl
Group 4
Diabetics
Receiving Insulin
alone (28)
116.63
8.98
1226.60
151.20
Group 5 Diabetics
Receiving Both
Oral Drugs &
Insulin (16)
112.38
10.82
242.31
16.60
26.36
6.16
199.93
5.65
234.51
22.20
25.52
3.17
189.28
3.28
1268.53
112.60
Gp 1 & 2 mentioned by *
Gp 3 & 4 by -
Gp 3 & 5 by -
Gp 5 & 3 by -
Table : 2
Table showing serum cholesterol profile Levels in Normal and Diabetic subjects in G-1&2 also diabetic subjects
receiving hypoglycemic drug and or Insulin in G-3, G-4 & G-5.
Parameters
Total Cholesterol
mg/dl
HDL Cholesterol
mg/dl
Group 1
Normal Subjects
(36)
Group 2
Diabetic Subjects
(130)
Group 3
Diabetics
Receiving Oral
Drugs alone (86)
Group 4 Diabetics
Receiving Insulin
alone (28)
144.22
26.12
41.38
9.36
253.58
35.90. ***
37.37
5.65
228.81
20.62
37.18
4.40
257.72
22.18
41.21
5.50
Group 5
Diabetics
Receiving Both
Oral Drugs &
Insulin (16)
242.48
19.90
38.25
6.23
13
Group 1
Group 3 Diabetics
Group 2
Normal Subjects Diabetic Subjects
Receiving Oral
(36)
(130)
Drugs alone (86)
Year 2012
Table showing plasma Glucose and Lipid Levels in normal subjects (Group 1) and diabetic subjects (Group 2),
diabetic subjects receiving hypoglycemic drugs (Group 3), diabetic subject receiving Insulin (Group 4) and in
diabetic subjects receiving both insulin and hypoglycemic drugs (Group 5).
Year 2012
Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid
Levels in Type 2 Diabetic Subjects
14
2
LDL Cholesterol
mg/dl
117.41
23.90
123.83
39.20. ***
120.61
12.81
VLDL Cholesterol
mg/dl
22.13
5.61
46.25
8.51. ***
45.50
6.16
136.23
16.58
47.33
8.18
130.30
15.18
44.38
6.78
Gp 1 & 2 mentioned by *
Gp 3 & 4 by -
Gp 3 & 5 by -
Gp 5 & 3 by -
Table : 3
Table Showing m TL,m TC ,m PL ,m TC/m PL ratio in Normal and Diabetic Subjects in G-1 &G-2 also diabetic
subjects receiving hypoglycemic drugs and or Insulin in G-3, G-4 & G-5.
Group-1
Normal
subjects
Group-2
Diabetic
Subjects
(36)
(130)
Group 3
Diabetics
Receiving
Oral Drugs
alone (86)
Group 4
Diabetics
Receiving
Insulin
alone (28)
Group5
Diabetics Receiving
Both Oral Drugs &
Insulin (16)
5.02
1.62
5.35
1.53
5.08
0.88
5.22
0.76
5.64
0.94
1.16
0.32
1.72
0.10***
1.68
0.63
1.76
0.36
1.69
0.48
7.36
1.78
8.18
0.88**
7.61
0.66
7.94
0.71
7.38
0.44
Parameters
Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid
Levels in Type 2 Diabetic Subjects
Membrane
Phospholipid/Cholesterol Ratio
(mPL/mTC)
6.40
0.64
4.73
0.28***
5.09
0.53
4.45
0.2
4.66
0.31
Year 2012
**/ / / p<0.01
***/ / p<0.001
Gp 1 & 2 mentioned by *
Gp 3 & 4 by -
Gp 3 & 5 by -
Gp 5 & 3 by -
15
Year 2012
Influence of Anti Diabetic Therapy on Plasma Lipid Profile and its Relation to Erythrocyte Membrane Lipid
Levels in Type 2 Diabetic Subjects
2
16