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1) delivery of oxygen and nutrients to, and removal of wastes from, tissue cells.
2) gas exchange in the lungs
3) absorption of nutrients from the digestive tract
4) urine formation in the kidneys
The rate of blood flow to each tissue and organ is almost exactly the right amount to
provide for proper function-no more, no less.
When the body is at rest:
1) brain receives 13% of total blood flow
2) heart about 4%
4) kidneys about 20%
5) abdominal organs 24%
6) skeletal muscles about 20%; increases during exercise
Velocity of blood: velocity of blood is inversely related to the cross sectional are of blood
vessels to be filled. (small C/S= faster velocity)
In the aorta cross-sectional are is 2.5 cm2, and velocity is approx. 45 cm/sec.
(small C/S=faster velocity)
in all the capillaries (at the same time), the C/S area is 4500 cm2, and velocity is
less than 0.03 cm/sec. (large C/S=slower velocity)
Slow velocity in capillaries is beneficial in order to allow adequate time for
exchange between the blood and tissue cells. Velocity speeds up as it enters the
venous system on its way to the heart because the total cross-sectional are
declines.
Autoregulation: the automatic adjustment of blood flow to each tissue in proportion to
the tissue's requirements at any instant.
Oxygen is the principle stimulus for autoregulation. Low oxygen in cells (in
immediate area) will produce and release vasodilator or substances to decrease
resistance and increase blood flow to capillaries.
metabolic control: Nitric acid (carried by hemoglobin), K+, H+, adenosine and
lactic acid produce a local vasodilation of arterioles & relaxation of precapillary
sphincters. (NO is very brief)
Myogenic control: vascular smooth muscle responds to stretch due to increased
blood pressure; muscle will counter by constricting, and vice versa
increased blood flow and increased oxygen very important for meeting nutritional
demands in muscles (skeletal blood flow might increase up to 10x)
Skeletal Muscles:
while resting blood flow is about 1L/min with approx. 25% of capillaries open,
with increased metabolic activity it may increased by 10x. (increased activity
leads to hyperemia)
Brain:
This system in the brain is the most precise in the body
auto-reg. is controlled not by decreased oxygen (only) but by increased carbon
dioxide and increased pH (increased acidity)
increased neuronal firing due to increased use of a specific region of the brain will
also increase blood supply to that area
myogenic respons:
1) with decreased systemic blood pressure, vasodilation of brain arterioles will
result. With increased systemic blood pressure, vasoconstriction of brain arterioles
will result
2) protects smaller vessels in brain and will keep blood flow constant, 750 ml/min
Skin:
Blood flow through the skin:
1) supplies the nutrients to the cells
2) aids in body temperature regulation
3) provides a blood reservoir
supplying nutrients to cells: primary function is to respond to oxygen needs in
skin and meet their demand
body temperature regulation:
1) by releasing heat via superficial capillary beds. Due to the extensive venous
plexus, blood flow can vary from 500 ml/min to 1900 ml/min, as a direct result of
body temperature differences
2) temp. controls are found in the hypothalamus: with increase in body temp.
hypothalamus will cause an increase in blood flow through "true" capillaries of the
skin, and with a decrease in body temp. blood will flow only through vascular
shunts (throughfare and metarterials), and the true capillaries will close.
blood reservoir: 60% of blood is found in the venous system at any time
lungs:
less pressure is needed to move blood through the lungs
arteries in pulmonary circulation have very thin walls with large lumens
auto-reg. decrease in oxygen will lead to vasoconstriction and increase in oxygen
will cause vasodilation (like the brain but opposite to other tissues) The blood
will bypass areas of congestion and go to other areas where there are
functional alveoli for efficiency.
heart:
blood flow stops when ventricles contract, because of cardiac vessel compression
and aortic semilunar valves close over the coronary artery openings. Blood flow
resumes with ventricular relaxation and valves moving out of the way
at the heart resting rate, the heart pumps approximately 250 ml/min; strenuous
exercising may cause the heart to pump up to 750 ml/min
heart tissue uses 65% of oxygen delivered, other body tissues use only 25%
there will be dilation of coronary vessels as a result of increased carbon dioxide,
hydrogen ions, or decreased oxygen