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TITLE:

High Profile Studies of Vitamin K2 Provide Hope for Parkinson's Patients


SUMMARY
A study from the laboratory of Patrik Verstreken published in the prestigious journal Science
describes an exciting discovery in relation to Parkinsons-related PINK1 deficiency. Specifically,
they discovered that vitamin K2 alleviates the negative effects of the Parkinsons specific PINK1
mutations in fruit flies.
Author:
Katie Jodscheidt, NASM-CPT, FNS
Founder of Innerzyme
Article:
Parkinsons disease (PD) is a common neurodegenerative disorder affecting the central nervous
system. This devastating disease affects part of the brain associated with critical functions, such
as vision, hearing and movement (1). With an absence of definitive markers for Parkinsons,
diagnosis is made on a clinical basis. With 60,000 new cases every year in the U.S. there are
nearly one million Americans living with PD, costing an astounding $25 billion per year (2).
The most obvious symptoms of PD are shaking, rigidity and slow movement, exemplified by the
famous PD patient, actor Michael J. Fox (3). The symptoms are a result of the death of a specific
type of cell in the aforementioned midbrain that produces dopamine, resulting in lower levels of
this neurotransmitter that is crucial for regulation of movement and other functions.

For many patients there are no definitive causes or risk factors for Parkinsons disease, most
likely being triggered by a combination of genetic and environmental factors (mix of nature and
nurture). On the other hand, some PD cases are attributed to mutations in specific genes(4).
These mutations have adverse effects on the function of the proteins in which they code for,
resulting in significant biological defects. One such Parkinsons gene is PINK1 (5,6,7). PINK1
functions in powerhouse of the cell, the mitochondria, and is involved with neuron
differentiation (8).

A study from the laboratory of Patrik Verstreken published in the prestigious journal Science
describes an exciting discovery in relation to Parkinsons-related PINK1 deficiency (9).
Specifically, they discovered that vitamin K2 alleviates the negative effects of the Parkinsons
specific PINK1 mutations in fruit flies. Flies are one the most prevalently used organisms in
genetic and biological studies. Their utility lies within their ease of use, as well as the fact that
the inner workings and cellular activities of these little animals reflect what occurs within our
cells. Conservation of machinery and processes between flies and humans results in the majority
of scientific discoveries in flies holding true for humans as well.

The Verstreken lab discovered the connection between PINK1 and vitamin K2 by beginning
their experiments with a poor flying PINK1 mutant fly. Subsequently, they selectively looked for
additional mutations in the flies that resulted in poorer flight ability. The rationale behind this
standard genetic approach was to find genes that were involved in the same processes as PINK1,
with the hypothesis that a poorer flying mutant would have a mutation in something related to
PINK1s role in flight. They found that the worst flying double mutant had an additional
mutation in the HEIX gene, which is involved in vitamin K2 synthesis in bacteria and humans.

With the data suggesting that vitamin K2 is involved with PINK1 in flight, they asked whether
feeding PINK1 mutant fruit flies vitamin K2 could alleviate their poor flight, as well as other
symptoms. Amazingly, PINK deficient flies fed vitamin K2 had significantly improved flight,
energy levels, and survival rates compared to flies not supplemented with vitamin K2.
Encouragingly, the observed improvements with vitamin K2 were dose-dependent and timedependent, characteristic of prototypical drugs and supplements. Further experiments
demonstrated that the improvements were most likely due to improved mitochondria function,
meaning more efficient energy production. Digging even deeper, the researchers discovered that
vitamin K2 could transport electrons, an essential step in energy production.

Altogether the experimental results described in this paper constitute a significant leap in our
scientific understanding of the potential of vitamin K2, as well as encouraging news for those
suffering from Parkinsons. Since the publication of the Verstreken labs findings researchers
have found that vitamin K2 synthesis is also crucial for embryonic and vascular development
(10, 11). Adding to the encouragement is the fact that vitamin K2 is a natural form of vitamin K.
These new discoveries, as well as the general nature of vitamin K2s improvement of energy
production provide ample support for the idea that vitamin K2 can help people suffering from
other diseases and disorders, as well as a general supplement to improve overall health and wellbeing.

References:
1. Breedlove et. al., Biological Psychology, 6th Edition, 2010.
2. http://www.pdf.org/en/parkinson_statistics.
3. Brockes, "It's the gift that keeps on taking". The Guardian, 11 April 2009.

4. Nuytemans et. al.,; "Genetic etiology of Parkinson disease associated with mutations in
the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update", Human
Mutation 31 (7): 763780 (2010).
5. Valente et. al., (2004). "Hereditary early-onset Parkinson's disease caused by mutations in
PINK1", Science 304 (5674): 115860 (2014).
6. Pimenta de Castro et. al., "Genetic analysis of mitochondrial protein misfolding in
Drosophila melanogaster", Cell Death and Differentiation 19 (8): 130816 (2012).
7. Valente et. al., "PINK1 mutations are associated with sporadic early-onset
parkinsonism", Annals of Neurology 56 (3): 33641 (2004).
8. Dagda et. al., "Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through
protein kinase A", Journal of Neurochemistry 128(6):864-77 (2014).
9. M. Vos et. al., Vitamin K2 is a mitochondrial electron carrier that rescues PINK1
deficiency, Science 336(6086):1306-10 (2012).
10. Nakagawa et. al., Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic
development of mice PLOS One. Aug 15;9(8):e104078 (2014).
11. Hegarty et. al., UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial
cell survival and development Development. 140(8):1713-9 (2013).

About the Author:


Katie Jodscheidt is a Fitness Nutrition Specialist and Certified Personal Trainer through the
National Academy of Sports Medicine (NASM). Katie is passionate about helping others
improve their overall quality of life by improving their health. Her mission is to educate people
on how to live a healthy lifestyle through proper diet, exercise and nutritional supplementation.
With years of research on natural health alternatives and collaborating with highly trained
physicians around the world, Katie Jodscheidt founded Innerzyme in 2011. Innerzyme is
revolutionizing the natural health industry with specially formulated, ethically created digestive
and systemic enzymes and the highest potency, natural Vitamin K2, MK-7 on the market with
one vegetarian capsule yielding 300mcg (as menaquinone-7 from Non-GMO fermented
soybeans. Recommended daily dosage of Innerzyme Vitamin K2 is to take one (1) vegetarian
capsule (300mcg) per day, or as directed by your healthcare practitioner. All Innerzyme
supplements are made in the USA in a cGMP certified facility.

For More Information:

Website: http://www.innerzyme.com
Buy Innerzyme Vitamin K2, MK-7, 300mcg: http://www.BuyInnerzyme.com
Facebook: http://www.facebook.com/innerzyme
Twitter: http://www.twitter.com/innerzyme (@innerzyme)
Instagram: http://www.instagram.com/innerzyme (@innerzyme)
Contact
Katie Jodscheidt, NASM-CPT, FNS
(480) 284-8478
info@innerzyme.com

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