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Seat

No.

R - 335
Subject : Biopharmaceutics and Pharmacokinetics Code : 55631
Final Year B. Pharm. - Sem - VII

Day and Date : Friday, 05-12-2014

Time : 02.30 p.m. to 04.30 p.m.


Total Marks: 40

Note: 1) All the questions are compulsory.


2) Figures to the right indicate full marks.

SECTION-I
(Multiple choice questions)
Q.1. Attempt the following multiple choice questions

(10)

1.

Henderson-Hesselbach equation determines........


a) relative amount of ionized and unionized drug in solution at a particular
pH.
b) percent of drug ionized at a particular pH.
c) pH at the absorption site.
d) all of the above.

2.

Dissolution test apparatus no-1 as per USP consist..........


a) reciprocating disc

b) paddle

c) rotating cylinder

d) rotating basket

3.

A drug that reverses plasma-protein binding is often referred as.........


a) protein hydrolysate
b) displacer
c) solvate
d) carrier substance

4.

Which of the following is known as Diazepam binding site?


a) Site I
b) Site II
c) Site III
d) Site IV

5.

Which of the following enzymes affect presystemic metabolism?


a) Lumenal enzymes
b) Phosphogenase
c) Bacterial enzymes
d) Both a and c
1

6.

As per biopharmaceutical classification system, class-II drugs come


under.
a) high solubility and high permeability
b) low solubility and low permeability
c) high solubility and low permeability
d) low solubility and high permeability

7.

8.

The study of variations in drug response as influenced by time is called as....


a) pharmacodynamics

b) pharmacokinetics

c) chronopharmacology

d) pharmacogenetics

Ficks first law of diffusion is best expressed by....


a) dQ/dt = PCGIT
b) dQ/dt = DAKm/w (CGIT C)/ h
c) dC/dt = K (Cs - Cb)
d) none of the above

9.

. is defined as time delay to the commencement of first order drug


absorption
a) n-log time
c) ended time

10.

11.

12.

b) log time
d) lag time

The pH of the stomach is


a) 1 to 3

b) 1 to 8

c) 4 to 8

d) 5 to 7

Absorption of poorly soluble drug is


a) diffusion rate limited

b) dissolution rate limited

c) both a and b

d) none of the above

Compartment models are also known as.


a) mammillary models

b) caternary models

c) both a and b

d) none of the above

13.

14.

15.

16.

17.

18.

19.

20

Drugs having . half-lives take a very long time to achieve plateau


concentration.
a) shorter

b) intermediate

c) longer

d) None of the above

Factors that produce an alteration in binding of drug to extravascular


components result in.
a) increase in Vd

b) decrease in Vd

c) no change in Vd

d) none of the above

Nonoral extravascular route include


a) pulmonary drug administration

b) sublingual drug administration

c) buccal drug administration

d) all of the above

Phase II reactions are known as.......


a) conjugation reactions
c) true detoxification reactions

b) synthetic reactions
d) all the above

Ex-vivo models are..


a) in the body

b) in the computer

c) outside the body

d) none of the above

Urine flow rate is significantly influences drug excretion if excretion


mechanism is
a) glomerular filtration

b) tubular secretion

c) tubular reabsorption

d) all of the above

The time at which the drug action initiated is called


a) onset of action

b) duration of action

c) onset time

d) all of the above

... is the time needed to reach maximum drug concentration in plasma.


a) Cmax

b) AUC

c) Ka

d) tmax

SECTION:- II

Q.2. Attempt any four of the following questions.


a) Define biopharmaceutics and explain the characteristics of passive
transport process.

(20)

b) How can the principle of binding be used for drug targeting?


c) Describe five applications of drug clearance.
d) What is meant by therapeutic range? Explain its importance with a
suitable example.
e) Describe the concept of noncompartment pharmacokinetics.

Q.3. Attempt any one of the following questions.


a) Discuss the factors influencing nonoral extravascular absorption of
drugs.
b) Explain the assumptions, schematic representation, equation and
applications of first order absorption kinetics.

(10)

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