Professional Documents
Culture Documents
and intraoperative
neuromonitoring
Nabil J. Azar, M.D.
Vanderbilt University Medical Center
Disclosure
SSEP- Definition
Presynaptic and postsynaptic responses
recorded over the limbs, spine, and scalp
following the stimulation of peripheral
nerves, trunks or cutaneous nerve.
(sensitivity VEP>SSEP>BAEP)
Intraoperative neuromonitoring (IONM)
Central sulcus localization
Prognosis in anoxic coma
Detecting conduction abnormalities along
central pathways > peripheral
Objective evidence of CNS dysfunction in the
setting of vague sensory symptoms
Evaluating spinal cord integrity after injury
Somatosensory Anatomy
5.
afferents.
Large diameter fibers have the highest
contribution to the potentials.
Lesion of posterior columns has biggest impact
on SSEPs.
The highest amplitude SSEPs are obtained after
stimulation of ulnar and median nerves, and the
lowest amplitude SSEPs are obtained after
stimulation of cutaneous or dermatomal nerves.
Similarly in lower limb, tibial nerve produces
more reliable SSEP than peroneal nerve.
Age
Sex
Relaxed state
Sedated state
Height
Limb temperature
Neuropathy
Body habitus
SSEP- Artifacts
1.
2.
Stimulus rate: 2-5 Hz for upper extremity stimulation and 1-2 Hz for lower
extremity stimulation (rates greater than 10 Hz may cause an increase in latency
and decrease in amplitude).
Filter setting: 30-3000 Hz. (Not recommended to use the 60 Hz notch filter because
SSEP in this range contains important physiologic information).
Amplifier sensitivity: 10 V for the spine and scalp potentials and 20 V for
peripheral potentials.
UE Recording (ACNS)
Interpeak latencies
- EP-P13
- P13-N20
- EP-N20
Absolute latencies of individual peaks
- EP
- N20
LE Recording (ACNS)
Interside diff
0.87 ms
0.47 ms
1.20 ms
- Technical adequacy
Waveform latencies
Interpeak latencies
Side-to-side abnormalities
? Amplitude abnormalities
SSEP- Conclusions
SSEP records volume conducted activity arising
Intraoperative neuromonitoring
(IONM)
Patients own latencies preoperatively serve as baseline.
Populations norms are not applicable.
Spontaneous:
EMG (Electromyography)
EEG (Electroencephalography)
Evoked responses:
Technical issues
SSEPs in IONM
Intra-operative BAEP
BAEPs are elicited by auditory stimulation and
represent activity generated by the CN VIII and
brainstem.
BAEPs are useful for posterior fossa surgeries:
Trigeminal neuralgia.
Vestibular schwannoma resections.
Vertebrobasilar aneurysms.
Vascular malformation repairs.
Microvascular cranial nerve decompressions.
Skull based (especially posterior fossa), CPA tumor
resections.
Intra-operative BAEP
Operative procedures in or adjacent to the
CP angle carries an increased risk to the
auditory nerve and the brainstem.
Other CNs (usually V & VII) are monitored
via EMG in conjunction with BAEPs.
Intra-operative BAEP loss & postoperative
deafness is due to interruption of the blood
supply or traumatic transection of the
auditory nerve or cochlea.
Intra-operative BAEP
Latency increases of 0.5 to 1ms are borderline.
Latency increases of 1 to 1.5ms require
notification of the surgeon (alternatively a
10% increase could be used as criteria for
warning the surgeon).
Amplitude decrement of 50%.
Interpeak latencies can also be helpful but this
will vary with the patient according to the
baseline value; in general small changes from
baseline can be significant.
I-III: 2.1ms
III-V: 1.9ms
I-V: 4.0ms
Intra-operative BAEP
Certain specific conditions result in
transient or permanent alteration of BAEP:
Cerebellar retraction
Manipulation of auditory nerve,
Tumor dissection & debulking,
Patient repositioning,
Hypocarbia,
Lumbar drainage and dural opening.
Cerebrovascular surgery
Aortic cross-clamping
Brachial plexus surgery
Question 1:
SSEPs test the integrity of:
A- Corticospinal tract
B- Spinothalamic tract
C- Posterior columns *
D- Spinocerebellar tract
Question 2:
The N11-13 complex corresponds to:
A- Brachial plexus
B- Cauda equina
C- Cervicomedullary junction *
D- Thalamus
Question 3:
The first sign of ischemia on EEG during
IONM is :
A- Decrease in amplitude
B- Loss of high frequency waveforms *
C- Loss of occipital rhythm
D- All of the above
Question 4:
With median nerve stimulation, which of
the following may produce a false negative
cortical potentials:
A- Isoflurane
B- Nitrous oxide
C- Etomidate *
D- Desflurane