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63

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74

75

JUDUL PENELITIAN
PENGARUH KADAR GLUKOSA DARAH SEWAKTU TERHADAP
KELUARAN NEUROLOGIK PADA PENDERITA STROKE ISKEMIK
FASE AKUT NONDIABETIK
INSTANSI PELAKSANA

: RS DR. KARIADI SEMARANG

PERSETUJUAN SETELAH PENJELASAN

(INFORMED CONSENT)

Berikut ini naskah yang akan dibacakan pada Responden / Keluarga

Responden Penelitian :
Bapak / Ibu / Sdr Yth
Anda terpilih sebagai responden penelitian yang berhubungan dengan kadar
glukosa darah sewaktu sebagai faktor risiko pada penderita stroke yang anda /
keluarga anda alami.
Tindakan yang akan Bapak / Ibu / Sdr alami :
Dilakukan anamnesis (menggunakan kuesioner) dan pemeriksaan fisik
neurologik (menggunakan palu reflek dan senter).
Pengambilan sampel darah untuk pemeriksaan kadar glukosa darah
yang akan dilaksanakan 2 kali, pertama saat pasien masuk ke bangsal
rawat inap penyakit saraf dan kedua setelah 24 jam berikutnya.
Dilakukan penilaian status neurologik menggunakan skor NIHSS pada
perawatan hari ke 0, 1 dan saat pasien pulang atau hari ke 7.
Terimakasih atas kerjasama Bapak / Ibu / Sdr.
Setelah mendengar dan memahami penjelasan peneliti, dengan ini saya
menyatakan SETUJU / TIDAK SETUJU untuk ikut sebagai responden
penelitian.
Semarang, ................................
Peserta penelitian

Saksi

Peneliti

(dr. Edward Y.N)

76

DAFTAR PERTANYAAN DATA DASAR PENELITIAN

NO.
1
2
3
4

PERTANYAAN
IDENTITAS
Nomor penelitian
Tanggal pemeriksaan
Nama
Alamat

5
6
7

Nomor CM/Register
Tanggal/jam masuk RS
Jenis kelamin

8
9

Umur (tahun)
Status perkawinan

10

Pendidikan

11

Pekerjaan

12
13
14

ANAMNESIS
Defisit neurologis
Tanggal/jam serangan
Kedinian datang ke RS

15

Riwayat DM

16

Riwayat hipertensi

17

Riwayat merokok

18

PEMERIKSAAN FISIK
Tinggi badan (cm)

JAWABAN

1. Laki-laki
2. Perempuan
1. Kawin
2. Janda/duda
3. Belum kawin
1. SD
2. SLTP
3. SLTA
4. S1
5. Tidak sekolah
1. PNS / TNI
2. Wiraswasta
3. Pedagang
4. Buruh / Tani
5. Tidak bekerja

1. < 48 jam
2. 49 - 72 jam
1. Ya
2. Tidak
1. Ya
2. Tidak
1. Ya
2. Tidak

77

19
20

Berat badan (kg)

Body Mass Index

21
22
23
24
25
26

Glasgow Coma Scale

Tekanan darah (mmHg)
Nadi (x/menit)
Suhu (C)
Pernafasan (x/menit)
Jantung

27

Pemeriksaan EKG

31

PEMERIKSAAN NEUROLOGIS
Skor NIHSS < 48 jam onset
Skor NIHSS 49 - 72 jam onset
Skor NIHSS hari ke 7 onset
PEMERIKSAAN PENUNJANG
Lokasi infark

32
33
34
35
36

Kadar Hb (gr%)
Leukosit (mm3)
Trombosit (mm3)
Hematokrit (%)
Kadar glukosa darah sewaktu

37
38
39
40

Kadar kolesterol total (mg%)

Kadar Trigliserida (mg%)
Kadar HDL (mg%)
Kadar LDL (mg%)
KETERANGAN
Alasan pulang sebelum hari ke 7
onset

28
29
30

41

1. Kurus (< 18,5)

2. Nomal (18,5-25)
3. Overweight (25-30)
4. Obesitas (> 30)

1. Normal
2. Tidak normal
1. Normal
2. Tidak normal

1. Kortikal
2. Subkortikal
3. Batang otak
4. Campuran
5. Normal

1. < 48 jam onset

2. 49 - 72 jam onset
3. Hari ke 7 onset

78

NATIONAL INSTITUTES OF HEALTH STROKE SCALES (NIHSS)

NIHSS
1a

1b

1c

5a

5b
6a

Derajat kesadaran
0 = sadar penuh
1 = somnolen
2 = stupor
3 = tidak respon atau hanya terdapat reflek
Menjawab pertanyaan
0 = dapat menjawab dua pertanyaan dengan benar (misalnya bulan apa
sekarang dan usia pasien)
1 = hanya dapat menjawab satu pertanyaan dengan benar / tidak dapat
berbicara karena terpasang pipa endotrakeal atau disartria
2 = tidak dapat menjawab kedua pertanyaan dengan benar / afasia / stupor
Mengikuti perintah
0 = dapat melakukan dua perintah dengan benar (misalnya buka dan tutup
mata, kepal dan buka tangan pada sisi yang sehat)
1 = hanya dapat melakukan satu perintah dengan benar
2 = tidak dapat melakukan kedua perintah dengan benar
Gerakan mata konyugat horisontal
0 = normal
1 = kelumpuhan parsial
2 = deviasi konyugat yang kuat atau paresis konyugat total pada kedua
mata, tidak dapat diatasi dengan manuver okulosefalik
Lapangan pandang pada tes konfrontasi
0 = tidak ada gangguan
1 = hemianopia parsial
2 = hemianopsia total
3 = hemianopsia bilateral (termasuk juga buta kortikal)
Paresis wajah
0 = normal
1 = paresis ringan (sulkus nasolabialis mendatar, terdapat asimetri)
2 = paresis parsial (paresis total/hampir total wajah bagian bawah)
3 = paresis total (tidak ada gerakan dari wajah atas dan bawah)
Motorik lengan kiri
0 = tidak ada simpangan bila pasien disuruh mengangkat lengannya pada
posisi 90/45 selama 10 detik
1 = lengan menyimpang ke bawah sebelum 10 detik
2 = lengan terjatuh ke kasur atau badan atau tidak dapat diluruskan secara
penuh
3 = tidak dapat melawan gravitasi
4 = tidak ada gravitasi
9 = tidak dapat diperiksa
Motorik lengan kanan (idem)
Motorik tungkai kiri
0 = tidak ada simpangan bila pasien disuruh mengangkat tungkai pada
posisi 30 selama 5 detik
1 = tungkai menyimpang ke bawah sebelum 5 detik
2 = tungkai terjatuh ke kasur atau tidak dapat diluruskan secara penuh
3 = tidak dapat melawan gravitasi
4 = tidak ada gravitasi
9 = tidak dapat diperiksa

79

6b
7

Motorik tungkai kanan (idem)

Ataksia anggota badan
0 = tidak
1 = pada satu sisi
2 = pada kedua sisi
9 = tidak dapat diperiksa
8
Sensorik
0 = normal
1 = defisit ringan-sedang
2 = defisit berat (gangguan rasa raba pada wajah, lengan dan tungkai)
9
Bahasa terbaik
0 = tidak ada afasia
1 = afasia ringan sedang
2 = afasia berat
3 = mutisme
10 Disartria
0 = artikulasi normal
1 = disartria ringan sedang (masih dapat dimengerti)
2 = disartria berat
9 = tidak dapat diperiksa
11 Neglect / tidak ada atensi
0 = tidak ada
1 = gangguan bilateral dari salah satu modalitas berikut : pengenalan
personal, visual, taktil, dan spasial
2 = gangguan pada lebih dari satu modalitas
SKOR TOTAL NIHSS

80

HASIL ANALISIS DATA

Je nis ke lam in * Kate gori NIHSS hari ke 7 Cros s tabulation

Ringan
Jenis kelamin

Laki-laki
Perempuan

Total

Count
% of Total
Count
% of Total
Count
% of Total

7
21,9%
5
15,6%
12
37,5%

Kategori NIHSS hari ke 7

Sedang
Berat
Sangat berat
9
1
2
28,1%
3,1%
6,3%
7
1
0
21,9%
3,1%
,0%
16
2
2
50,0%
6,3%
6,3%

Total
19
59,4%
13
40,6%
32
100,0%

Des criptives
Umur

Mean
95% Conf idence
Interval f or Mean

Statistic
53,94
50,58

Low er Bound
Upper Bound

Std. Error
1,649

57,30

5% Trimmed Mean
Median
Varianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis

53,85
53,00
86,964
9,325
34
74
40
13
,188
-,155

,414
,809

um ur 51 * Kategori NIHSS hari k e 7 Cross tabulation

Ringan
umur
51

<51 tahun

Count
% w ithin Kategori
NIHSS hari ke 7
Count
% w ithin Kategori
NIHSS hari ke 7
Count
% w ithin Kategori
NIHSS hari ke 7

=51 tahun

Total

Kategori NIHSS hari ke 7

Sedang
Berat
Sangat berat
6
1
1

33,3%

37,5%

50,0%

50,0%

37,5%

10

20

66,7%

62,5%

50,0%

50,0%

62,5%

12

16

32

100,0%

100,0%

100,0%

100,0%

100,0%

Riw ayat Hipe rte ns i * Kate go ri NIHSS h ari ke 7 Cros s tab ulatio n

Ringan
Riw ayat Hipertens i

+
-

Total

Count
% of Total
Count
% of Total
Count
% of Total

Total
12

9
28,1%
3
9,4%
12
37,5%

Kategori NIHSS hari ke 7

Sedang
Berat
Sangat berat
12
2
2
37,5%
6,3%
6,3%
4
0
0
12,5%
,0%
,0%
16
2
2
50,0%
6,3%
6,3%

Total
25
78,1%
7
21,9%
32
100,0%

81

Dis lipide m ia * Kategori NIHSS hari k e 7 Cros stabulation

Dislipidemia

+
-

Total

Kategori NIHSS hari ke 7

Sedang
Berat
Sangat berat
11
1
2
34,4%
3,1%
6,3%
5
1
0
15,6%
3,1%
,0%
16
2
2
50,0%
6,3%
6,3%

Ringan
11
34,4%
1
3,1%
12
37,5%

Count
% of Total
Count
% of Total
Count
% of Total

Total
25
78,1%
7
21,9%
32
100,0%

Me rokok * Kategori NIHSS hari k e 7 Cros stabulation

Kategori NIHSS hari ke 7
Sedang
Berat
Sangat berat
5
0
1
15,6%
,0%
3,1%
11
2
1
34,4%
6,3%
3,1%
16
2
2
50,0%
6,3%
6,3%

Ringan
Merokok

Count
% of Total
Count
% of Total
Count
% of Total

Total

3
9,4%
9
28,1%
12
37,5%

Total
9
28,1%
23
71,9%
32
100,0%

Infark Miokard * Kategori NIHSS hari k e 7 Cros stabulation

Ringan
Inf ark Miokard

+
-

Total

Count
% of Total
Count
% of Total
Count
% of Total

5
15,6%
7
21,9%
12
37,5%

Kategori NIHSS hari ke 7

Sedang
Berat
Sangat berat
3
0
1
9,4%
,0%
3,1%
13
2
1
40,6%
6,3%
3,1%
16
2
2
50,0%
6,3%
6,3%

Total
9
28,1%
23
71,9%
32
100,0%

BMI * Kateg ori NIHSS h ari ke 7 Cr os stabulation

Ringan
BMI

Total

Normal (18,5 - 25)

Count
% w ithin
Overw eight (25 - 30) Count
% w ithin
Obesitas (> 30)
Count
% w ithin
Count
% w ithin

BMI
BMI
BMI
BMI

7
35,0%
4
40,0%
1
50,0%
12
37,5%

Kategori NIHSS hari ke 7

Sedang
Berat
Sangat berat
11
1
1
55,0%
5,0%
5,0%
5
0
1
50,0%
,0%
10,0%
0
1
0
,0%
50,0%
,0%
16
2
2
50,0%
6,3%
6,3%

Total
20
100,0%
10
100,0%
2
100,0%
32
100,0%

82

Des criptives
GDS < 48 jam

Mean
95% Confidence
Interval for Mean

Low er Bound
Upper Bound

5% Trimmed Mean
Median
Variance
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis

Statistic
117,47
106,74

Std. Error
5,260

128,20
115,69
106,00
885,289
29,754
73
194
121
35
1,073
,639

,414
,809

Tes ts of Norm ality

a

GDS < 48 jam

Kolmogorov-Smirnov
Statistic
df
Sig.
,187
32
,006

Statistic
,904

Shapiro-Wilk
df
32

Sig.
,008

a. Lilliefors Signif icance Correction

Des criptives
GDS 49 - 72 jam

Mean
95% Conf idence
Interval f or Mean

Low er Bound
Upper Bound

5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis

Statistic
115,06
105,46

Std. Error
4,707

124,66
113,52
108,00
708,899
26,625
71
182
111
32
1,070
,772

,414
,809

Tes ts of Nor m ality

a

GDS 49 - 72 jam

Kolmogorov-Smirnov
Statistic
df
Sig.
,160
32
,036

a. Lillief ors Signif icance Correc tion

Statistic
,906

Shapiro-Wilk
df
32

Sig.
,009

83

Des criptives
KOL. TOTA L

TRIGLISERIDA

HDL

LDL

Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis

Low er Bound
Upper Bound

Low er Bound
Upper Bound

Low er Bound
Upper Bound

Low er Bound
Upper Bound

Statistic
202,75
189,81

Std. Error
6,344

215,69
202,83
202,50
1287,742
35,885
129
280
151
44
-,034
-,110
122,13
102,73

,414
,809
9,512

141,52
117,31
105,00
2895,145
53,807
61
273
212
48
1,492
1,850
43,81
40,82

,414
,809
1,468

46,81
43,40
40,50
68,931
8,302
32
63
31
11
,772
-,061
125,56
114,71

,414
,809
5,322

136,42
124,92
122,50
906,190
30,103
79
184
105
38
,427
-,530

,414
,809

84

Tes ts of Normality
a

KOL. TOTAL
TRIGLISERIDA
HDL
LDL

Kolmogorov-Smirnov
Statistic
df
Sig.
,100
32
,200*
,189
32
,005
,177
32
,012
,140
32
,115

Statistic
,986
,842
,925
,943

Shapiro-Wilk
df
32
32
32
32

Sig.
,938
,000
,028
,089

*. This is a low er bound of the true signif icance.

a. Lillief ors Signif icance Correction

Je nis ke lam in * Kate gori NIHSS hari 7Gabung Cr os stabulation

Jenis kelamin

Laki-laki
Perempuan

Total

Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count

Kategori NIHSS hari

7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
7
12
7,1
11,9
5
8
4,9
8,1
12
20
12,0
20,0

Total
19
19,0
13
13,0
32
32,0

Chi-Square Te s ts

Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Ass ociation
N of Valid Cas es

Value
,009 b
,000
,009

,008

df
1
1
1

Asy mp. Sig.

(2-s ided)
,926
1,000
,926

Exac t Sig.
(2-s ided)

Exac t Sig.
(1-s ided)

1,000

,607

,927

32

a. Computed only for a 2x2 table

b. 1 cells (25,0%) have expec ted count less than 5. The minimum expec ted count is
4,88.

85

Riw ayat Hipe rte ns i * Kategori NIHSS hari 7Gabung Cross tabulation

Riw ayat Hipertens i +

Total

Count
Expected Count
Count
Expected Count
Count
Expected Count

Kategori NIHSS hari

7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
9
16
9,4
15,6
3
4
2,6
4,4
12
20
12,0
20,0

Total
25
25,0
7
7,0
32
32,0

Chi-Square Te s ts

Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases

Value
,110 b
,000
,108

df
1
1
1

,106

Asymp. Sig.
(2-sided)
,740
1,000
,742

Ex act Sig.
(2-sided)

Ex act Sig.
(1-sided)

1,000

,535

,744

32

a. Computed only for a 2x 2 table

b. 2 cells (50,0%) hav e expec ted count les s than 5. The minimum expected count is
2,63.

Dis lipide m ia * Kategori NIHSS hari 7Gabung Cros stabulation

Dislipidemia

+
-

Total

Kategori NIHSS hari

7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
11
14
9,4
15,6
1
6
2,6
4,4
12
20
12,0
20,0

Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count

Total
25
25,0
7
7,0
32
32,0

Chi-Square Te s ts

Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases

Value
2,060b
,987
2,302

1,996

df
1
1
1

Asymp. Sig.
(2-sided)
,151
,320
,129

Ex act Sig.
(2-sided)

Ex act Sig.
(1-sided)

,212

,161

,158

32

a. Computed only for a 2x 2 table

b. 2 cells (50,0%) hav e expec ted count les s than 5. The minimum expected count is
2,63.

86

Me rokok * Kategori NIHSS hari 7Gabung Cros stabulation

Merokok

Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count

Total

Kategori NIHSS hari

7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
3
6
3,4
5,6
9
14
8,6
14,4
12
20
12,0
20,0

Total
9
9,0
23
23,0
32
32,0

Chi-Square Te s ts

Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases

Value
,093 b
,000
,094

df
1
1
1

,090

Asymp. Sig.
(2-sided)
,761
1,000
,760

Ex act Sig.
(2-sided)

Ex act Sig.
(1-sided)

1,000

,546

,764

32

a. Computed only for a 2x 2 table

b. 1 cells (25,0%) hav e expec ted count les s than 5. The minimum expected count is
3,38.
Infark Miokard * Kategori NIHSS hari 7Gabung Cros stabulation

Inf ark Miokard

+
-

Total

Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count

Kategori NIHSS hari

7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
5
4
3,4
5,6
7
16
8,6
14,4
12
20
12,0
20,0

Total
9
9,0
23
23,0
32
32,0

Chi-Square Te s ts

Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases

Value
1,742b
,835
1,708

1,687

df
1
1
1

Asymp. Sig.
(2-sided)
,187
,361
,191

Ex act Sig.
(2-sided)

Ex act Sig.
(1-sided)

,240

,180

,194

32

a. Computed only for a 2x 2 table

b. 1 cells (25,0%) hav e expec ted count les s than 5. The minimum expected count is
3,38.

87

Kolmogorov Smirnov BMI dengan NIHSS hari ke 7

Fr eque ncies
BMI

Kategori NIHSS
Ringan
Sedang+Berat+
Sangat Berat
Total

N
12
20
32

Tes t Statis ticsa

Mos t Ex treme
Dif f erences

BMI
,067
,067
,000
,183
1,000

A bs olute
Positive
Negative

Kolmogorov-Smirnov Z
A sy mp. Sig. (2-tailed)

a. Grouping V ariable: Kategori NIHSS hari 7Gabung

Skor NIHSS <48 jam

Des criptives
Skor NIHSS < 48 jam

Mean
95% Confidence
Interval f or Mean

Low er Bound
Upper Bound

5% Trimmed Mean
Median
Variance
Std. Deviation

Statistic
9,78
6,43
13,13
8,80
7,00
86,176
9,283
1
37
36
8
1,838
2,715

Minimum
Maximum
Range
Interquartile Range
Skew nes s
Kurtosis

Std. Error
1,641

,414
,809

Tes ts of Nor m ality

a

Skor NIHSS < 48 jam

Kolmogorov-Smirnov
Statistic
df
Sig.
,252
32
,000

a. Lilliefors Significance Correction

Statistic
,753

Shapiro-Wilk
df
32

Sig.
,000

88

Kate gori NIHSS < 48 jam

V alid

Ringan
Sedang
Berat
Sangat berat
Total

Frequency
11
16
1
4
32

Percent
34,4
50,0
3,1
12,5
100,0

Cumulativ e
Percent
34,4
84,4
87,5
100,0

V alid Percent
34,4
50,0
3,1
12,5
100,0

Skor NIHSS 49-72 jam

Des criptives
Skor NIHSS 49 - 72 jam

Mean
95% Conf idence
Interval f or Mean

Low er Bound
Upper Bound

5% Trimmed Mean
Median
Variance
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew ness
Kurtosis

Statistic
9,31
6,05

Std. Error
1,601

12,58
8,30
6,50
82,028
9,057
1
37
36
8
1,878
3,145

,414
,809

Tes ts of Norm ality

a

Skor NIHSS 49 - 72 jam

Kolmogorov-Smirnov
Statistic
df
Sig.
,233
32
,000

Statistic
,767

Shapiro-Wilk
df
32

a. Lillief ors Signif icance Correc tion

Kate gori NIHSS 49 - 72 jam

V alid

Ringan
Sedang
Berat
Sangat berat
Total

Frequenc y
11
16
3
2
32

Percent
34,4
50,0
9,4
6,3
100,0

V alid Percent
34,4
50,0
9,4
6,3
100,0

Cumulativ e
Percent
34,4
84,4
93,8
100,0

Sig.
,000

89

Des criptives
Skor NIHSS hari ke 7

Mean
95% Conf idence
Interval f or Mean

Low er Bound
Upper Bound

5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis

Statistic
8,00
4,83

Std. Error
1,552

11,17
6,90
5,50
77,097
8,780
0
37
37
7
2,269
5,059

,414
,809

Tes ts of Norm ality

a

Kolmogorov-Smirnov
Statistic
df
Sig.
,250
32
,000

Skor NIHSS hari ke 7

Statistic
,714

Shapiro-Wilk
df
32

a. Lilliefors Significance Correc tion

Kate go ri NIHSS hari ke 7

V alid

Ringan
Sedang
Berat
Sangat berat
Total

Frequenc y
12
16
2
2
32

Percent
37,5
50,0
6,3
6,3
100,0

Friedman Test
Ranks
Skor NIHSS < 48 jam
Skor NIHSS 49 - 72 jam
Skor NIHSS hari ke 7
Tes t Statis ticsa
N
Chi-Square
df
A sy mp. Sig.

32
39,973
2
,000

a. Friedman Test

Mean Rank
2,47
2,20
1,33

V alid Percent
37,5
50,0
6,3
6,3
100,0

Cumulativ e
Percent
37,5
87,5
93,8
100,0

Sig.
,000

90

Analisis Post Hoc Wilcoxon

Ranks
N
Skor NIHSS hari ke 7 Skor NIHSS < 48 jam

Skor NIHSS hari ke 7 Skor NIHSS 49 - 72 jam

Skor NIHSS 49 - 72 jam

- Skor NIHSS < 48 jam

23 a
0b
9c
32
20 d
0e
12 f
32
7g
0h
25 i
32

Negative Ranks
Positive Ranks
Ties
Total
Negative Ranks
Positive Ranks
Ties
Total
Negative Ranks
Positive Ranks
Ties
Total

Mean Rank
12,00
,00

Sum of Ranks
276,00
,00

10,50
,00

210,00
,00

4,00
,00

28,00
,00

a. Skor NIHSS hari ke 7 < Skor NIHSS < 48 jam

b. Skor NIHSS hari ke 7 > Skor NIHSS < 48 jam
c. Skor NIHSS hari ke 7 = Skor NIHSS < 48 jam
d. Skor NIHSS hari ke 7 < Skor NIHSS 49 - 72 jam
e. Skor NIHSS hari ke 7 > Skor NIHSS 49 - 72 jam
f . Skor NIHSS hari ke 7 = Skor NIHSS 49 - 72 jam
g. Skor NIHSS 49 - 72 jam < Skor NIHSS < 48 jam
h. Skor NIHSS 49 - 72 jam > Skor NIHSS < 48 jam
i. Skor NIHSS 49 - 72 jam = Skor NIHSS < 48 jam

Tes t Statisticsb

Z
A sy mp. Sig. (2-tailed)

Skor NIHSS
hari ke 7 Skor NIHSS
< 48 jam
-4,268a
,000

a. Based on positive ranks .

b. Wilc oxon Signed Ranks Tes t

Skor NIHSS
hari ke 7 Skor NIHSS
49 - 72 jam
-4,089a
,000

Skor NIHSS
49 - 72 jam Skor NIHSS
< 48 jam
-2,392a
,017

91

20

15

10

0
73 81 86 92 93 97 100 103 105 107 108 113 116 119 125 127 135 140 141 157 163 168 186 194

gds_0

D_NIHSS2
30

20

10

0
Observed
-10

Linear
0

100

200

300

400

GDS_0

D_NIHSS2 = selisih NIHSS 48 jam onset dengan hari ke 7 onset

92

Cas e Proces s ing Sum m ary

GDS_0
Positivea
Negative
Mis sing

V alid N
(listw ise)
3
33
1

Larger values of the tes t res ult variable(s ) indicate

stronger ev idenc e f or a positive ac tual s tate.
a. The positive ac tual s tate is 105.

ROC Curve
1.00

.75

.50

.25

0.00
0.00

.25

.50

.75

1.00

1 - Specificity
Diagonal segments are produced by ties.

Are a Under the Cur ve

Test Result V ariable(s ): D_NIHSS2

A rea
.571

Std. Error
.112

A sy mptotic
b
Sig.
.689

A sy mptotic 95% Conf idence

Interval
Low er Bound Upper Bound
.351
.790

The test result variable(s ): D_NIHSS2 has at least one tie betw een the
positive actual state group and the negative actual state group. Statistic s
may be biased.
a. Under the nonparametric assumption
b. Null hypothesis: true area = 0.5

93

Coordinate s of the Curve

Test Res ult V ariable(s ): D_NIHSS2
Positive if
Greater Than
a
or Equal To
-1.00
.50
1.50
2.50
11.50
21.00

Sens itiv ity

1.000
1.000
.333
.000
.000
.000

1 - Specif ic ity
1.000
.667
.364
.152
.030
.000

The test result variable(s ): D_NIHSS2 has at leas t one tie

betw een the pos itiv e ac tual s tate group and the negative
ac tual s tate group.
a. The smallest c utof f value is the minimum
observ ed tes t value minus 1, and the largest cutoff
value is the maximum observ ed tes t value plus 1.
All the other cutof f v alues are the av erages of tw o
cons ecutive ordered obs erved test values.
Cor relations
Spearman's rho

GDS_0

D_NIHSS1

D_NIHSS2

Correlation Coeffic ient

Sig. (2-tailed)
N
Correlation Coeffic ient
Sig. (2-tailed)
N
Correlation Coeffic ient
Sig. (2-tailed)
N

GDS_0
1.000
.
36
.176
.306
36
-.149
.386
36

**. Correlation is s ignificant at the 0.01 level (2-tailed).

Cas e Proces s ing Sum m ary

GDS_0
Positivea
Negative
Mis sing

V alid N
(listw ise)
1
35
1

Larger values of the tes t res ult variable(s ) indicate

stronger ev idenc e f or a positive ac tual s tate.
a. The positive ac tual s tate is 107.

D_NIHSS1
.176
.306
36
1.000
.
36
.671**
.000
36

D_NIHSS2
-.149
.386
36
.671**
.000
36
1.000
.
36

94

ROC Curve
1.00

.75

.50

.25

0.00
0.00

.25

.50

.75

1.00

1 - Specificity

Are a Under the Cur ve

Test Result Variable(s ): D_NIHSS2

Area
1.000

Std. Error
.000

Asy mptotic
b
Sig.
.092

Asy mptotic 95% Conf idence

Interval
Low er Bound Upper Bound
1.000
1.000

a. Under the nonparametric assumption

b. Null hypothesis: true area = 0.5

Coordinate s of the Curve

Test Res ult V ariable(s ): D_NIHSS2
Positive if
Greater Than
a
or Equal To
-1.00
.50
1.50
2.50
11.50
21.00

Sens itiv ity

1.000
1.000
1.000
1.000
1.000
.000

1 - Specif ic ity
1.000
.686
.343
.114
.000
.000

a. The smallest c utof f value is the minimum

observ ed tes t value minus 1, and the largest cutoff
value is the maximum observ ed tes t value plus 1.
All the other cutof f v alues are the av erages of tw o
cons ecutive ordered obs erved test values.

95

Cas e Proces s ing Sum m ary

V alid N
(listw ise)
1
35
1

GDS_0
Positivea
Negative
Mis sing

Larger values of the tes t res ult variable(s) indicate

stronger ev idence for a positive ac tual s tate.
a. The positive actual s tate is 108.

ROC Curve
1.00

.75

.50

.25

0.00
0.00

.25

.50

.75

1.00

1 - Specificity
Diagonal segments are produced by ties.

Regression
V ariables Enter ed/Re m ovebd
Model
1

V ariables
Entered
GDS_0a

V ariables
Remov ed
.

Method
Enter

a. A ll requested variables entered.

b. Dependent Variable: D_NIHSS2

Model Sum m ary

Model
1

R
.114 a

R Square
.013

A djusted
R Square
-.016

a. Predictors: (Constant), GDS_0

Std. Error of
the Estimate
3.321

96

ANOVAb
Model
1

Regression
Residual
Total

Sum of
Squares
4.926
375.074
380.000

df

Mean Square
4.926
11.032

1
34
35

F
.447

Sig.
.508 a

a. Predictors: (Constant), GDS_0

b. Dependent Variable: D_NIHSS2

Coe fficientsa

Model
1

(Constant)
GDS_0

Unstandardiz ed
Coef f icients
B
Std. Error
2.521
1.393
-.006
.010

Standardized
Coef f icients
Beta
-.114

t
1.809
-.668

Sig.
.079
.508

a. Dependent Variable: D_NIHSS2

Cut off point kadar GDS 105 mg/dl :

Kate gori NIHSS hari 7Gabung * Hiper glike m ia Cross tabulation

Count

Kategori NIHSS
hari 7Gabung

Ringan
Sedang+Berat+
Sangat Berat

Hiperglikemia
Euglikemia
Hiperglikemia
7
5

Total

Nilai duga positif

= 11/20 = 55 %

Nilai duga negatif

= 7/12 = 58,3 %

Sensitivitas

= 11/16 = 68,75 %

Spesifisitas

= 7/16 = 43,75 %

Total
12

11

20

16

16

32

= (1-specificity) = 9/16 = 56,25 %

= (1-sensitivity) = 5/16 = 3,25 %
Likelihood ratio positive = 68,75 / 56,25 = 1,2
Likelihood ratio negative = 31,25 / 43,75 = 0,71