Professional Documents
Culture Documents
in Medicine
Contents
Progress
Popularisation
Demonisation
Research
Renaissance and Culture
What is a Psychedelic
Experience?
Synaesthesia
Enables access to inner thoughts and feelings that are usually repressed
Ego dissolution
Increased affectivity
Dream-like experience, but in clear consciousness with full awareness of self and good memory of the
experience
Further descriptions of
Peyote Cactus
Henry Havelock-Ellis British
physician and psychologist
Isolation of Mescaline
Arthur Carl Wilhelm
Heffter - German
pharmacologist
American
psychologist
Brother of the
author Henry
James
The Varieties of
Religious
Experience (James,
1902).
Synthesis of
(synthetic) Mescaline
Ernst Spth
chemist
- Austrian
Mescaline and
Eidetic Imagery
Heinrich Klver
German and American
psychologist
Using mescaline as a
research tool discovered the
nature of eidetic imagery,
(Klver, 1928).
Described recurring
geometric patterns: lattices
(honeycombs,
checkerboards and
triangles) Cobwebs, tunnels
and spirals.
Discovery of LSD
Wasson
Huxley
MK-ULTRA
Popularisation of psychedelics
Leary
Hollingshead
Hubbard
Psychiatric Psychedelic
Heydays
Psychotomimetic
Psycholytic Psychotherapy
Addictions
Meta-analyses
Psychotomimetic
Self-experimentation by mental health
professionals
3. Psychedelic Psychotherapy
4. Psycholytic Psychotherapy
Low doses
Frequent, regular sessions
Favoured in the UK
18
20
Dr Ronald Sandison:
British Psychiatrist and Psychoanalyst
Organic
Psychosis (DTs)
Peak
Experience
Sobriety
Psychedelic
Experience
(Chandler Al. & Hartman Ma. (1960) LSD-25 as a Facilitating Agent in Psychotherapy.AMA Arch Gen Psychiatry; 2(3):
286-299)
Review of 20 years of psychedelic therapy in the UK, 4000 patients and 50,000
psychedelic drug-assisted sessions.
Two completed suicides
Thirty-seven patients with a prolonged psychosis
(Malleson, N. (1971) Acute Adverse Reactions to LSD in clinical and experimental use in the UK. Br J Psychiatry. 18(543):229-30)
"Treatment with LSD is not without acute adverse reactions, but given adequate
psychiatric supervision and proper conditions for its administration, the incidence of such
reactions is not great,"
Safety Profile of
Psychedelics
Krebs TS, Johansen P- (2013) Psychedelics and Mental Health: A Population Study. PLoS ONE 8(8): e63972.
doi:10.1371/journal.pone.0063972
Physiological risks
Virtually zero
Dependency risks
Hallucinogen Persisting
Very low
Very low
Physiological risks
Low
Dependency risks
Hallucinogen Persisting
Low
Rare
BUT..
Leo Zeff:
Psychologist and Jungian
psychotherapist based in
California
Had used LSD in his practice
until 1966.
Had retired until introduced
MDMA in 1976 by Dr
Alexander Sasha Shulgin.
David E. Nichols,
and Alexander
Shulgin publish the
first report into the
psychoactivity of
MDMA in humans
in 1978.
3,4 Methylenedioxymethamphetamine
(MDMA)
Couples Therapy
But
Psychedelic Renaissance
The clinical
Burden of PTSD
Very disabling
Polypharmacy common
Completed Studies
DMT human dose-response study
Strassman,R.J. (1996) Human psychopharmacology of N,N-dimethyltryptamine. Behav. Brain Res.73, 121-124 )
Psilocybin to treat Obsessive Compulsive Disorder
Moreno FA, Wiegand CB, Taitano EK & Delgado PL. Safety, tolerability, and efficacy of psilocybin in 9 patients
with obsessive-compulsive disorder. .J Clin Psychiatry.2006;67:17351740 )
Psilocybin and the Spiritual Experience
Griffiths, R.R., Richards, W.A., McCann, U., & Jesse, R. (2006). Psilocybin can occasion mystical experiences
having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 187, 268283
MDMA to treat PTSD
Mithoefer et al (2013) Durability of Improvement in PTSD Symptoms and absence of harmful effects or drug
dependency after MDMA-assisted Psychotherapy: A Prospective Long-Term Follow-up Study. J
Psychopharmacol, 2013. 27:28-39
Psilocybin to treat Anxiety in end-stage cancer
Grob, C., Chopra, A.L. Danforth, M.C. Hagerty, C.R. McKay, A.L. Halberstadt, and G.R. Greer (2010) Pilot Study of
Psilocybin Treatment for Anxiety in Advanced-stage Cancer Patients[with G.S.].Arch Gen Psychiatry, 68(1):71-78
LSD to treat Anxiety in end-stage cancer
Gasser, P.
41
Contemporary Psychedelic
Research in the UK
The Cardiff
MDMA project
Ben Sessa, Mat Hoskins and Jon Bisson
Cardiff University Hospital Medical School
David Nutt Imperial College, London
CUBRIC, MAPS and Imperial University,
London
Double-blind, placebo controlled crossover fMRI study of combat veterans with chronic
treatment-resistant PTSD.
Twenty-four subjects will receive two fMRI scans; one with 125mg of MDMA and a second, two weeks
later, with an inactive placebo.
Measure the neurobiological correlates of MDMA vs. Placebo using four behavioural paradigms, which
relate directly to the symptoms of PTSD.
Participants recruited from the University Hospital of Wales Veterans Service, screened according to
safety and diagnostic suitability criteria and randomly allocated into one of two groups.
46
David Nichols
David Nutt
Daniel Pinchbeck
Jonathan Ott
Roland Griffiths
Torsten Passie
Amanda Feilding
Rick Doblin
Robin Carhart-Harris
Rupert McShane
Ann Shulgin
Matt Johnson
Teri Krebs
Dale Pendell
Hattie Wells
Andrew Feldmar
Alicia Danforth
Ben Sessa
Buying Drugs
On the Internet:
MDPV, Methylenedioxypyrovalerone,
Methedrone (para-methoxymethcathinone, PMMC)
Methylone (3,4-methylenedioxy-N-methylcathinone, MDMC)
Naphyrone (NRG-1)
Pentedrone and Pentylone (NRG-3)
Knowingly illegal.
Uses encrypted Tor browser.
Untraceable (?)
Payment by Bitcoins.
Phenethylamine-based drugs
2C-C, 2,5-dimethoxy-4-chlorophenethylamine
2C-D, 2,5-dimethoxy-4-methyl-phenethylamine
2C-E, 2,5-dimethoxy-4-ethyl-phenethylamine
2C-G, 3,4-dimethyl-2,5-dimethoxyphenethylamine
2C-I, 2,5-dimethoxy-4-iodophenethylamine
2C-T-2, 2,5-dimethoxy-4-ethylthiophenethylamine
2C-T-4, 2,5-dimethyoxy-4-(i)-propylthiophenethylamine
2C-T-7, 2,5-dimethoxy-4-(n)-propylthiophenethylamine
2C-T-21, 2,5-dimethoxy-4-(2-fluoroethylthio)phenethylamine
2CB-FLY
Bromodragonfly
DOB, 2,5-dimethoxy-4-bromoamphetamine
DOC, 2,5-dimethoxy-4-chloroamphetamine
DOI, 2,5-dimethoxy-4-iodoamphetamine
DOM, 2,5-dimethoxy-4-methylamphetamine
TMA-2, 2,4,5-Trimethoxyamphetamine
TMA-6, 2,4,6-Trimethoxyamphetamine
NBOMe-2C-C, 25C-NBOMe, "Pandora"
NBOMe-2C-I, 25I-NBOMe, "Solaris"
NBOMe-2C-D, 25D-NBOMe, "Divination"
RTI-121
()-2-Carboisopropoxy-3-(4-iodophenyl) tropane (RTI-121, IPCIT)
Potent and long-lasting. A single dose can last for over ten hours. (Which
restricts its abuse potential).
RTI-126
()-2-(1,2,4-oxadiazol-5-methyl)-3-phenyltropane)
A potent monoamine reuptake inhibitor. Five times more potent than cocaine.
Fast onset of effects and short duration of action. The closest to cocaine itself
out of all the drugs in the RTI series.
Herbs/plants/fungi/animals
Salvia, Kratom, Iboga, Kava Kava, Ayahuasca, Datura, mushrooms,
toads, sponges, flies, fish etc.
Synthetic Cannabinoids
Initially thought to be herbs: Coastal Jackbean, Blue Egyptian water lily, dwarf skullcap,
lion's tail, lotus and honeyweed.
T 0:00 - 2 blotters are placed between the gums and cheek, one on top and one on the bottom lip. This is not
complexed but since it is the hydrochloride salt of 25-I, it is well absorbed if proper buccal technique is observed. I
personally recommend keeping the blotters in contact with the gums/cheeks in various positions even as the drugs
effects come on.
T+0:30 - Although many say this is a slow-to-develop experience, I have noticed the familiar shimmer and
intensifying of colors while also feeling a building energy - some friends have noted this come up as 'frightening' in
intensity but compared to the 2C line it is just a small buildup of energy.
T+1:00 - I decide it is time to prepare a shower as I find the effects building and building. My pupils are already
dilating at this point and I can feel fluctuations in body temperature much more. There is a bubbling in the stomach
that I would not call nausea by any means - just something I noted. In fact food/hunger is not only perfectly normal
but strangely enjoyable tripping on 25-I, whereas with LSD and most other psychedelics I find any unnatural foods
bizarre and unappealing. As I shower I also note the physical pleasure of this chemical coming on - I can imagine it
would be a potent aphrodisiac used in the right setting.
T+2:00 - I decide to take a night time bike ride with headphones - great idea! I am feeling the euphoria kicking in full
force now and combined with the small but noticeable 2C-x energy I venture deep into the woods. At this point I can
not fully see because the visuals are multiplying rapidly. I stop and smoke a cigarette and contemplate how hard it is
for an American to find secluded nature anymore. I feel apologetic for paving over natural landscapes and natural
beauty with our suburban and urban centers. At this point I note my euphoria is stronger than anything I have felt in
my life previously (possibly due to the extreme affinity for this molecule to certain receptors).
T+3:00 - Time dilation has begun and the entire world is awash in patterns and tracers. A note about pattern
recognition. Visually, at least, this chemical seems to play tricks with the brains system of 'filling in' periphery. Usually
when I focus on a point the brain fills in the rest of my vision with memory and logical assumptions - while on 25-I
this trick of the mind is exposed. I focus on a point and it becomes almost 4-D in clarity as the entire periphery flows
with reccurring patterns the mind inserts to fill in the lack of visual stimuli. These are not like any other visuals I have
seen which are usually purely geometrical - they are also MC Escher-esque in repetition - rows and rows of horses
marching into shadows of other rows of horses - tree branches interconnecting and exploding out in ways that defy
physics, etc.
T+4:00 - At this point time becomes of no concern. I walk around the street with my dogs and feel extreme empathy
and understanding towards them. It is as if we are linked. Conversation with some friends at this point is very fun as I
can interact with an almost unnoticeable amount of confusion - as we all know other psychedelics that produce such
profound effects also seem to profoundly affect communication and thought. 25-I, at moderate-strong dosages
seems to leave my sanity and social abilities intact which still rewarding the user with incredible physical/mental
euphoria and inexplicably beautiful visuals.
3D Molecular Printing
Usage
Opposition to Reform:
Moral argument
The Forefather of
Psychedelic Therapy
in Britain?
The future may teach us how to
exercise a direct influence, by
means of particular chemical
substances, upon the neural
apparatus. It may be that there
are other still undreamt of
possibilities of therapy.
From An Outline of Psychoanalysis
Sigmund Freud
London 1938.