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Pharmacology

Vd is directly proportional to ECV and tissue binding but inversely proportional to plasma protein

binding (PPB). Therefore, the higher the Vd, the lower the PPB.
Drugs with zero order kinetics: phenytoin, ethanol, aspirin
Bioavailability
AUC degree of drug absorption
Cholinergic receptors
Nicotinic receptors
Noradrenergic receptors
Skeletal muscle tremor due to beta 2 effect. Therefore, b2 antagonist would help remove the tremor.

i.e. Propanolol
For acute angle closure glaucoma: Pilocarpine
Contraindicated in acute angle closure glaucoma: Atropine
GI and bladder atony: Betanechol
"Sufficient quantity": qs
Rx - superscript
Direction to the pharmacist - subscript
Direction to the patient transcription
Basis, adjuvant, corrective, vehicle self explanatory
Anticholinergic of choice for asthma: Ipratropium bromide
Ipratropium bromide is usually given with: Salbutamol
Needs drug monitoring due to its narrow margin of safety: Theophylline
Long half-life of salmeterol is due to its: High lipophilicity
Patients are instructed to gargle after taking this drug (budesonide) to prevent: Oral candidiasis
Can be used with other drugs for helicobacter pylori infection: Bismuth sulcralfate
Anti-emetic for chemotherapy induced nausea and vomiting: Ondansentron
Ulcer/ Zollinger-ellison/Gastroesophageal disease: Omeprazole
Acetazolamide side effect: hyperchloremic metabolic acidosis; Indicated for glaucoma and acute

mountain sickness
Which diuretic is the best for calcium stones: Thiazides
Which diuretic is best for HPN: Thiazides
Which diuretic is best for heart failure: Loop diuretics
Most common indication for your carbonic anhydrase inhibitor: Glaucoma
What diuretic will cause stone formation: Loop diuretics
Aldosterone antagonist: Spironolactone
Most common site of digitalis toxicity: GIT
Inc Ca, dec K, dec Mg risk factors for digitalis toxicity: Furosemide/ Amiodarone
MOA as a PDE inhibitor Bipyridines (Milrinone/inamrinone)
Beta drugs with ISA - Labetalol
Highest probability of torsade de pointes: Class III
Not a prodrug for ACE inhibitors: Captopril
Block GPIIb/IIIa (i.e. Tirofiban, eptifibatide): Abciximab
Antihyperlipidemic that is a ligand of PPAR: Fibrates
Fibrates + statins are not recommended due to w/c side effect: Rhabdomyolysis
Which drug will inhibit the HMG-Coa reductase inhibitors: Statins
Anti-epileptic agent that produces paradoxical hyperactivity in children: Phenobarbital
Anti-epileptic used for SIADH: Carbamazepine

SSRI's, have delayed effect due to: Post receptor down regulation
Action is affected by kinetics at low and high dose: Phenytoin
Most potent psychopharmacologic, for schizophrenia: Haloperidol
Indicated for all types of seizures (grand mal, absence, myoclonic seizures): Valproic acid
Side effect of psychopharmacologic drugs: Motor dysfunction
Displaces phenytoin from CHON binding: Aspirin
Gabapentin
Anticonvulsant with bad effect to heart: Phenytoin?
Anticonvulsant best for acute epileptic attacks: Diazepam?
Antibiotic with the same spectrum of activity as aminoglycosides: Aztreonam
Antibiotic which has a decreased absorption in presence of food: Phenoxymethylpenicillin or penV
Antifungal that can safely cross BBB: Fluconazole
Antiviral drug that prevents uncoating of virus: Amantadine
Antiviral drug that prevents the release of virus: Oseltamivir
Antiviral drug that prevents penetration: Enfurvitide
Antiparasitic drug for amebic cyst passers but do not kill tissue trophozoites: Diloxanide furoate
Antiparasitic drug for tissue trophozoites but not amebic cysts: Metronidazole
Antimalaria drug for radical cure: Primaquine
Anti-TB drug that is used to reduce emergence of resistance: Ethambutol
Anti-TB drug for latent infection (boy, exposed to TB): Isoniazid 9mos.
Anti-TB drug that has a biphasic kinetics: Isoniazid
Anti-TB drug for slowly growing tubercle bacilli: Pyrazinamide
Anti-TB drug that can also be used in leprosy: Rifampicin
Drug for multibacillary leprosy: Clofazimine
Non-depolarizing neuromuscular blocker whose metabolite laudanosine can induce seizures when it

gets accumulated and requires greater anesthetic concentration: Atracurium


Accumulation of O-toluidine metabolite: Prilocaine
Anesthetic drug that can cause cardiac toxicity: Halothane
Condition that is resistant to non-depolarizing neuromuscular blockers: Severe burns
Steroid for salt-losing addisons disease: Fludrocortisone
Least sedating 1st gen. H1 blocker: Chlorphenamine
Antithyroid drug for rapid improvement of symptoms in goiter: Iodide
Anti-thyroid for pregnant women: PTU
Anti-thyroid for compliance: Methimazole
SERM beneficial effect to bone but not to breast: Raloxifene
Anti-diabetic drug for obese patients with good renal function: Metformin
Anti-diabetic sulfonylurea drug good for elderly patients: Tolbutamide
Drug for prostate cancer: Flutamide
Vincristine (adverse effect): Neurotoxicity
Cyclophosphamide (adverse effect): Hemorrhagic cystitis
Cisplatin (adverse effect): Nephrotoxicity
Doxorubicin (adverse effect):
First sign of salicylate toxicity: Hyperventilation & respiratory alkalosis
Lead accumulates where in children: Bone marrow
Heparin (antidote): Protamine
Warfarin should not be used for pregnant women: Heparin more advisable
Breastfeeding women are more prone to pass on to their babies their drug intake when drug is taken:
before breastfeeding

Magnesium Ma = madaming poopoo se: diarrhea


Aluminum Al = ala wAlang poopoo se: constipation
-tidine = h2 antagonist
Cimetidine enzyme inhibitor; hormonal adverse effects
Famotidine most potent
-azole = proton pump inhibitor
Dopamine alpha 1, beta 1, dopamine receptors
At low doses causes vasodilation
Disopyramide and flecainide, verapamil negative inotropic effect
Beta-blockers
Calcium Channel Blockers
Cephalosporins