GPSSafetySummary

Aminotris(methylenephosphonicacid)
anditssodiumsalts

ChemicalIdentity

Brandnames

Briquest30150A;Briquest30130SH;Briquest30132S

CASnumbers

Chemicalname(IUPAC)

[bis(phosphonomethyl)amino]methylphosphonicacid

Molecularformula

Synonyms

Tris(methylenephosphonicacid)amine;ATMPH;
ATMPxNa

Molecularweight

6419198(ATMPH)
20592852(ATMPxNa)
C3H12NO9P3
C3H(12x)NO9P3Nax
299g/mol(ATMPH)
321to431g/mol(ATMPxNa)

Applications

ATMPacidanditssodiumsaltsaremainlyusedasscaleinhibitorsinwatertreatment.Thesephosphonatesubstancesarealsousedindetergent
andcleaningapplications,inpaper,textileandphotographicindustriesandinoffshoreoilapplications.

SafetyAssessment,ExposureandRiskManagementRecommendations

Physicalandchemicalproperties

Property
Physicalstate(puresubstance)
Form
Colour
Odour
FreezingPoint
Relativedensity
Flashpoint
Vapourpressure
Watersolubility
Octanolwaterpartition
Metalcorrosion

Result
Solidat20C
Manufacturedasanaqueoussolution
Colourlesstopaleyellow
Veryfaint
ca.10C
1.31.4atroomtemperature
Notapplicabletoaqueoussolution
Verylowpotentialforvolatility
Miscible
Lowpotentialforbioaccumulation
Maycausecorrosiontometals

Healtheffects

ATMP acid, Na salt and 6Na salts cause serious eye

irritation whereas ATMP2Na to 5Na salts are not
classified for eye irritation. For industrial uses,
stringent safety measures must be observed. For
moredetails,pleaserefertotheSafetyDataSheet.
For consumer applications, ATMP is used in suitable
concentrationsaccordingtoappropriateregulations.

Environmentaleffects

ATMP acid and its sodium salts are soluble in water

but they are not readily biodegradable. ATMP has a
low potential for bioaccumulation and is not
classifiedasdangerousfortheenvironment.
Disposal, treatment or recycling must comply with
applicableregulationstopreservetheenvironment.

Regulatoryinformationandcertifications

Classificationandlabelling

Registrationandcertification

EUregulation(EC)1272/2008(CLP)

Hazardclassand HazardStatement
Impactedsubstances
category
AMTPH;ATMPNa;
Metalcorrosion, H290Maycause
Cat.1
corrosiontometals.
ATMP2Na
Eyeirritation,
H319Causesserious
AMTPH;ATMPNa;
eyeirritation.
ATMP6Na
Cat.2

N.B.:ATMP3Nato5Nasaltsarenotclassifiedatall,accordingto
Warning theregulationcriteria.

ATMPGPSSafetySummaryRev0Nov2012

EUregulationforchemicals(EC)1907/2006(REACH)
ISO9001:2008certified

ATMPacidanditssodiumsaltsareformulatedtocomplywith
requirements of most stringent regulations for applicable
consumer uses. They can be safely used in suitable
concentrationsaccordingtoappropateregulations.

I/I

GPSSafetySummary

This Product Safety Summary is intended to provide a general overview of the chemical substance in the
contextof ICCAGlobalProductStrategy.Theinformationon theSummaryisbasicinformationandisnot
intended to provide emergency response information, medical information or treatment information. The
summaryshouldnotbeusedtoprovideindepthsafetyandhealthinformation.Indepthsafetyandhealth
informationcanbefoundonthe(extended)SafetyDataSheet(e)SDSforthechemicalsubstance.

Aminotris(methylenephosphonicacid)
anditssodiumsalts

GeneralStatement

ATMPacidanditssodiumsaltsaremainlyusedasscaleinhibitorsinwatertreatment.Thesephosphonate
substances are also used in detergent and cleaning applications, in paper, textile and photographic
industriesandinoffshoreoilapplications.

PureATMPissolidbutthesubstanceismanufacturedandmarketedasacolourlesstopaleyellowaqueous
solution.ATMPacidandsomeofitssodiumsaltsmaycausecorrosiontometalsandmaycauseseriouseye
irritationtoavaryingdegreedependentuponthepH/degreeofneutralization.

The marketed products, used in industry or for professional purpose, must be handled under stringent
safety conditions at the workplaces, in accordance with the risk management measures to keep the
exposureatasafelevelandpreservehumanhealthandenvironment.

ATMP use in consumer products is minor, it may be found at low level in detergents, personal care
products or fertilizers; it is formulated in suitable concentrations according to appropriate regulations to
ensuresafeuse.

ChemicalIdentity

Name

ATMPacid

ATMPNasalt

Na
salt

2Na
salt

3Na
salt

4Na
salt

5Na
salt

6Na
salt

Brandname

Briquest30150A

CASnumber
ECnumber
Molecular
formula
Molecular
weight

6419198

Briquest30130SH
Briquest30132S
20592852

7611509

94021235

2235430

15505052

2439000

4105015

2291465

2238789

2315208

3014168

2187918

2395346

C3H12NO9P3

C3H(12x)NO9P3Nax

X=1

X=2

X=3

X=4

X=5

X=6

299g/mol

321to431g/mol
forx=1to6

321

343

365

387

409

431

[bis(phosphonomethyl)
amino]methylphosphonic
acid

Nitrilotrimethylene
triphosphonicacid

Nitrilotrimethylene
triphosphonicacid,
sodiumsalt

Aminotris(methyl
phosphonicacid)
ATMP,ATMPH,NTMP
Tris(methylenephosphonic
acid)amine,Nitrilotri
methylphosphonicacid

ATMPxNa

Chemical
name(IUPAC)
ECname

Synonyms

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Structure:

x Na

withx=1to6

Amino tris (methylenephosphonic acid) and its sodium salts belong to the ATMP category in that all
categorymembersarevariousionizedformsoftheacid.Thesealsoincludepotassiumandammoniumsalts
ofthatacid(notconsideredinthissummary).Thedifferentsaltsarepreparedbyneutralizingtheacidtoa
specific pH. The substances are available in aqueous solution only. The properties of the members of a
categoryareconsistentacrossallendpoints.Somepropertiesforasalt,inecotoxicitystudies,forexample,
canbedirectlyappreciatedbyanalogytotheparentacidones.Wherestudiesresultsareavailable,theacid
andsaltsareconsideredseparately.

Usesandapplications

ATMPmayspecificallybeusedasanintermediateforproducingthephosphonatessalts.Thesaltisusedin
situ(usuallythecase)orstoredseparatelyforfurtherneutralization.

Amajorapplicationofphosphonatesisintreatmentofcoolingandboilerwatersystemsasscaleinhibitors.
Inparticular,forATMPanditssodiumsalts,preventionoftheformationofcalciumcarbonatescale.
Phosphonatesofthistypearealsousedtopreventscaleformationinsqueezeapplicationsinoffshore
oilfielduse.
Phosphonatesareusedasstabilizersforperoxides,particularlyinpulpbleachinginpaperindustryorinthe
scouringandbleachingprocessesoftextileindustry.
Phosphonatesofthiscategoryareusedinconsumerdetergentapplicationsasadditivestoprovidearange
of properties such as antiredeposition and soil dispersion or as perborate and percarbonate stabilizers
preventing decomposition by transition metals. These substances act as a chelating agent and hydrogen
peroxidestabilisersinpersonalcareproductssuchasbarsoapsandhaircarepreparations.Furtherusesin
specificindustrialandprofessionaldetergentformulationsmaybefoundinhardsurfacecleaning,vehicle
washinganddairycleaning
Thesubstancesarealsodispersantandscaleinhibitingagentinsomeagriculturalfertilizerpreparations.
Theymaybeusedalsoasadispersantandviscosityconditionerincoatingsandinceramicsslurry,theywill
bedegradedincaseofhightemperatureprocess.
Phosphonates can be used as chelating agent in weaving and dyeing industries and as metal surface
treatmentagent.

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Physical/ChemicalProperties

Phys/ChemSafetyAssessment

Property

Value

Physicalstate
Form
Colour
Odour
Relativedensity
FreezingPoint
BoilingPoint

Solidat20Candatmosphericpressure
Manufacturedasanaqueoussolution
Colourlesstopaleyellow
Veryfaint
1.31.4atroomtemperature
ca.10Catatmosphericpressure
Nodataavailable(evaporationofaqueoussolution
followedbydecomposition(>178C)ofthe
substance)
Notapplicabletoaqueoussolution
2.7x109Paat25C(estimated)
5001000g/lat25C,miscibleinwater
3.53,lowpotentialforbioaccumulation
Maycausecorrosiontometals

Flashpoint
Vapourpressure
Watersolubility
OctanolWaterpartitioncoefficient(logKow)
Metalcorrosion

Basedonavailabledata,ATMPacid,ATMPNaand2Nasaltsareclassifiedascorrosivetometalsregarding
physicalandchemicalhazardsinaccordancewithEUregulation(EC)1272/2008criteria.

HealthEffects

HumanHealthSafetyAssessment

EffectAssessment

Result

AcuteToxicity
Oral/inhalation/dermal
Irritation/corrosion
Skin/Eye

Notclassifiedforacutetoxicity,basedonavailablestudies
resultsonoralanddermalroutesofexposure.
Basedonavailabledata,ATMP4Nasaltmaybeamildirritant
and5Namaybeslightlyirritatingtotheskin,notresultingin
classification.
ATMPacid,Naand6Nasaltscauseseriouseyeirritation.
ATMP2Nato5Nasaltsarenotclassifiedforeyeirritation.
Notclassifiedforskinsensitization,basedonanimaldataand
humanexposurereports(ATMPsaltsarenotclassifiedby
analogywithATMPacid).
Notclassifiedfortoxicityafterrepeatedexposure,basedon
ATMPacidstudiesresults.
Notclassifiedeitherformutagenicityorgenotoxicity.
Neithertheacidnorthesaltinducedgenemutationsin
bacteria.ATMP6Nasaltdidnotinducechromosomedamage
eitherinvitroorinvivoandATMPanditssaltsdonothave
anystructuralalertsforgenotoxicactivity.

Sensitisation

Toxicityafterrepeatedexposure
Oral/inhalation/dermal
Genotoxicity/Mutagenicity

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Carcinogenicity

Notclassifiedforcarcinogenicity.
ATMPsodiumsaltsarenotexpectedtobecarcinogenic;by
analogywithATMPacidstudiesresults.
ATMPacidisnottoxicforreproduction,basedonratsthree
generationstudy.Byanalogy,ATMPsaltsarenotexpectedto
haveatoxiceffectneitheronfertilitynorondevelopment.

Toxicityforreproduction

LowpH(<2)wouldpredictthatATMPacidshouldbeseverelyirritantorcorrosivetoskinaswellaseyes,
howeveravailableexistinganimaldataindicatingnonclassificationtakeprecedenceinaccordancewithEU
regulation(EC)1272/2008criteria.

EnvironmentalEffects

EnvironmentSafetyAssessment

EffectAssessment
AquaticToxicity

Result
Notharmfultoaquaticorganisms(shorttermandlongterm
exposure)
ATMPcanleadtogrowthinhibitioninalgae,butthiseffectisa
consequenceofthesubstance'scomplexationwithessential
nutrientsandnotoftruetoxicity.

Fateandbehaviour
Biodegradation
Bioaccumulationpotential
PBT/vPvBconclusion

Result
Neitherreadilynorinherentlybiodegradable
Partiallyphotodegradableovershorttimeperiod
Notpotentiallybioaccumulative(LogKow=3.53)
NotconsideredtobeeitherPBTorvPvB

Based on available data, ATMP acid and its salts are not classified as dangerous for the environment,
accordingtoEUregulation(EC)1272/2008.

Exposure

Exposure assessment is based on overall releases that may occur during a given lifecycle stage of the
substance. The potential of the effects on human health and on environment is considered in the risk
assessmentandtheriskofexposureiscontrolledfrommanufacturetoenduseproductbyappropriaterisk
managementmeasures.

Humanhealth

ATMP acid is manufactured in industry, in closed, automated processes which ensure that the risk is
controlled. However, workers may be exposed during un(loading), mixing, sampling, analysis or
maintenanceoperationsandparticularlyincaseofbatchprocessesandsprayapplications.Wherethereis
a risk of exposure, it should be kept as minimum as possible and at safe levels (strictly below exposure
limits, when applied) by the use of appropriate risk management measures as suitable collective and
personal protective equipment, good industrial hygiene practices and risk communication through
appropriatetrainingofworkers.

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Consumersarelikelytocomeincontactwiththesubstancewhenusingdetergents,personalcareproducts
or garden fertilizers containing ATMP. ATMP is formulated in suitable concentrations to comply with
requirements of the most stringent regulations for all applicable consumer uses. Conditions of safe use,
writtenonthepackaging,ensurecontrolledconsumerriskofexposure.

Environment

Based on the relevant physicalchemical properties, the known uses and the fact that it is not readily
biodegradable,ATMPanditssaltswillpartitionprimarilytowaterandsuspendedsediments.ATMPandits
saltsarenotexpectedtobioaccumulate.
The extremely low vapour pressure and very high water solubility of ATMP and its salts indicate that
volatilizationisnegligible.

Onindustrialandprofessionalsites,controlledaqueousreleasesaredirectedtoawastewatertreatment
plant.Consumerapplicationseffluentsmustbedirectedtoamunicipalwastewatertreatmentplant.Inthe
treatmentplantsthesubstancewillberemovedfromwastewaterbyadsorptionontothesludgeswhich
maybeappliedasagriculturalfertilizer.

RiskManagementRecommendations

Humanhealth

ForindustrialandprofessionalusesofATMPinsolutionandasrecommendedfortheuseofanychemical
product,workersmustbewellinformedandtrainedandmustrefertothe(extended)SafetyDataSheet
(eSDS).
Where there is a risk of exposure to ATMP in solution (during (un)loading, mixing, sampling, analysis or
maintenance operations and particularly in case of batch processes and spray applications), it must be
controlled by handling the product under an adequate ventilation with an effective exhaust ventilation
system.Appropriatepersonalprotectiveequipmentmustbewornasrecommendedinthe(e)SDS(safety
spectacles,gogglesorafaceshielddependingonthetask,appropriategloves,protectivesuit).Incaseof
mist,sprayoraerosolexposure,arespiratorwithapprovedfiltershouldbeused.Generalindustrialhygiene
measures are required to ensure safe handling of the substance: Emergency equipment immediately
accessible;usewellmaintainedPPE;washhandsandskinfollowingcontact;donoteat,drinkorsmokeat
theworkplace.

As ATMP is corrosive to metals, acid resistant materials should be used. It should not be mixed with
incompatiblematerialssuchasstrongoxidizingagentsoralkalisandcausticproducts.

For consumer uses, ATMP in solution is formulated in suitable concentrations, according to appropriate
regulations. Final products can be used safely in the conditions of use written on the packaging (avoid
contactwitheyesbyusingsuitableeyeprotection).

Environment

Whilstnotclassifiedforenvironmentalhazard,ATMPisshowntohavesomeeffectonaquaticorganisms.
All industrial, professional and consumer aqueous releases that may contain the substance must be
controlledanddirectedtoa(biological)wastewatertreatmentplant.
Disposal, treatment or recycling of industrial waste must comply with applicable regulations to preserve
environment.

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StateAgencyReview

ATMPacidanditsNasaltshavebeen
registeredunder:

ATMPacidanditsNasaltshavebeen
reviewedunderthefollowingregulatory
and/orvoluntaryprogrammes:

EUregulation(EC)1907/2006(REACH)

HighProductionVolumeChemicalsProgramme,
publishedbyUNEPin2004
EUHERAproject(establishedbyCeficandAISE)in1999

RegulatoryInformation/ClassificationandLabelling

ClassificationandlabellingofATMPacidanditssaltsaccordingtoEUregulation(EC)1272/2008(CLP):

Classification

Hazardstatements

MetalCorrosion,Category1

Notclassified

H290 Maycausecorrosion
tometals.
H319 Causesseriouseye
irritation.

Labelling

EyeIrritation,Category2

Pictogram
Signalword

Acid

Na
salt

2Na
salt

3Na
salt

4Na
salt

5Na
salt

X
X

X
X

Acid

Na
salt

2Na
salt

3Na
salt

4Na
salt

5Na
salt

6Na
salt

Warning

Nopictogram,
nosignalword

Warning
Precautionarystatements:

P234 Keeponlyinoriginalcontainer.
P264 Washthoroughlyafterhandling.
P280 Wearprotectivegloves/protectiveclothing/eye
protection/faceprotection.
P390 Absorbspillagetopreventmaterialdamage.
P305+P351+P338 IfINEYES:Rinsecautiouslywithwater
forseveralminutes.Removecontactlenses,if
presentandeasytodo.Continuerinsing.
P337+P313Ifeyeirritationpersists:getmedical
advice/attention.
P406 Storeincorrosiveresistant/...containerwitha
resistantinnerliner.

6Na
salt

X
X
X

X
X

X
X
X

X
X

X
X

NoPrecautionary
statement

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ContactInformationwithinCompany

ForfurtherinformationonthissubstanceorProductSafetySummariesingeneral,pleasecontact:

RhodiaGlobalProductStrategy:http://www.rhodia.com/en/sustainability/global_product_strategy/index.tcm

Contact:globalproductstrategy@eu.rhodia.com

AdditionalInformation

ICCAGlobalProductStrategy:http://www.iccachem.org/en/Home/ICCAinitiatives/globalproductstrategy/

(extended)SafetyDataSheetavailableondemand:http://www.rhodia.com/en/contact/contact_form_business.tcm

Glossaryoftechnicalterms:http://www.rhodia.com/en/sustainability/global_product_strategy/glossary/index.tcm

Dateofissue:November2012
Revision:0

Disclaimer

The information provided in the present Safety Summary is based on European data available in REACH
regulatorydossier(ECN1907/2006)andiscorrecttothebestofourknowledge,informationandbeliefat
thedateofitspublication.Suchinformationisonlyintendedtoprovideageneraloverviewofthechemical
substance in the context of ICCA Global Product Strategy and is not to be considered as a warranty or
qualityspecification.Itdoesnotreplacethesafetydatasheetandtechnicalsheets.Thus,theinformation
providedinthisSafetySummaryonlyrelatestothedesignatedspecificproductandmaynotbeapplicable
if such product is used in combination with other materials or in another manufacturing process, unless
otherwise specifically indicated. It does not release the user from ensuring he is in conformity with all
regulationslinkedtoitsactivity.

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