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PC ON ELDER PATIENTS

Backgrounds

Multiple diseases
Multiple medications
DIA
approximately 30% of patients age 75 or older
with two or more chronic conditions take at
least 5 prescription drugs regularly
home residents this number may be as high as
7 or more drugs

Older patients visit multiple physicians for


treatment of various conditions
No/ lack of Coordinating medications among
pysiciants
Increase risk for adverse drug reactions (ADRs).
Ex. Older patient with hypertension and
depression
guanethidine to reduce blood pressure +
tricyclic antidepressant concurrently

Problems

Decrease organ functions


Dose and intervals
Drug interaction
More adverse drug effect
More morbidity and mortality

Problems

Potential / actual compliance


Untreated indication
Drug with no indication
Repeat prescription no longer required
Inappropriate duration of therapy
Discrepancy between doses prescribed and
used
Potential drug-disease interaction

Problems

Potential/suspected ADR
Monitoring issues
Potential ineffective therapy
Education required
Inappropriate dosage regime

Age and morbidity realionship

Age related pharmacokinetics and


pharmacodynamic

Absorbtion transdermal
Distribution <body fluid vol
Protein binding alteration <
Metabolism <
Excretion <
Receptor sensitivity

Factors influence functional age

Nutritional status
Smocking of non smocking
Presence of acute or chronic disease (s)
Acute or chronic therapy
Active or non active habit
Health insurance
Living Dependent or independency in the
Family

seven all-too-often-deadly sins of


prescribing.
The disease for which a drug is prescribed
is actually an adverse reaction to another
drug, masquerading as a disease
A drug is used to treat a problem that,
although in some cases susceptible to a
pharmaceutical solution, should first be
treated with commonsense lifestyle changes.

The medical problem is both self-limited and


completely unresponsive to treatments such as
antibiotics or does not merit treatment with
certain drugs.
A drug is the preferred treatment for the
medical problem, but instead of the safest, most
effectiveand often least expensive
treatment, the physician prescribes one of the
Do Not Use drugs listed on this web site or
another, much less preferable alternative.

Two drugs interact. Each on its own may be


safe and effective, but together they can
cause serious injury or death.
Two or more drugs in the same therapeutic
category are used, the additional one(s) not
adding to the effectiveness of the first but
clearly increasing the risk to t
The right drug is prescribed, but the dose is
dangerously highhe patient

Example of miss prescribing


The increased use of anti-Parkinsons drugs to treat drug-induced
parkinsonism caused by the heartburn drug
metoclopramide7 (REGLAN) or by some of the older antipsychotic
drugs.
A sharply increased use of laxatives in people with decreased
bowel activity that has been caused by antihistamines such as
diphenhydramine (BENADRYL), antidepressants such as
amitriptyline (ELAVIL)a Do Not Use drugor some antipsychotic
drugs such as thioridazine (MELLARIL).8
An increased use of antihypertensive drugs in people with high
blood pressure that was caused or increased by very high doses of
nonsteroidal anti-inflammatory drugs (NSAIDs), used as painkillers
or for arthritis.9
Failing to Treat Certain Problems with Nondrug Treatments

General services
General services are available such as
Smoking cessation programme
Supervised administration of methadone
Contraception including emergency hormonal
contraceptive services
Anticoagulant Monitoring
Medicines Use Review

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Pharmacist

Clinical medication review (CMR)


Pharmacist reviewed the patient, the illness,
and the drug treatment.
Evaluated
appropriateness and efficacy of treatments
progress of the conditions
compliance
actual and potential adverse effects interactions

The outcome of the review was a decision


about the continuation (or otherwise) of the
treatment.
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Geriatric Care Principles


spectrum of clinical management not only
treatments
interventions for their conditions
Screening, preventive and advanced illness
care.
Individualize
Restricted choice of medication
to improve the coordination of treatments.

Pharmaceutical care
Reduce polypharmacy
Ensure appropriate treatment
Help elderly patients understand their
medicines

Comorbidity DIA (cont)

Health services
Early (and ongoing) comprehensive
multidisciplinary assessment of the biomedical,
psychosocial and functional status of the older
person
Tailored treatments, diagnostic and therapeutic
interventions that focus on the syndromes and
diseases associated with ageing
Care planning in consultation with the older
person, their family, carer and the community
services involved in their care

Specific services
Person-centred practice
initial assessment by the interdisciplinary team
Mobility, vigour and self care encourage
mobilisation
Nutrition - encouragement and support to eat
and drink,
Continence encourage use of toilet
Medication pharmacy review,
Cognition considers, delirium, dementia,
depression

Skin Integrity
Oral health care

QUENTIONS?

Case
Nyonya R 63 tahun dengan riwayat heartburn sedang berobat
sendiri dengan obat bebas. Akhir-akhir ini ia merasa nyeri d
tangan . Dokternya mendiagnosa bahwa dia menderita arthritis
dan menulis resep ibuprofen untuknya.
Akan tetapi Mrs. R tidak menjelaskan bahwa ia memnggunakan
obat bebas untuk nyeri ulu hatinya. Setelah beberapa minggu
menggunakan obat ibuprofen secarav teratur, Mrs. R dia merasa
nyeri dadanya semakin bertambah. Dia akhirnya dilarikan ke
emergency, tapi setelah menjalani berbagai test, dokter nya
menyatakan bahwa ia menderta serangan jantung.
Di samping dokter percaya bahwa ny. R mengalami interaksi
obat.

questions
Apa masalah ny R, Apakah masalah tersebut
ada kaitannya dengan obat? Obat apa?
jelaskanlah
Bagaimana menyelesaikan masalah orang ini?
Apa rencana pelayanan anda?
Perlukan penggantian obat? Obat untuk apa
dan apa terapi alternatifnya?

Key
the ibuprofen aggravated her heartburn severely,
causing the intense chest pain.To alleviate the
condition, the ER doctor contacts Mrs. Rs primary
care physician to propose an alternate arthritis
drug, which does not
result in gastrointestinal side effects such as
heartburn. In addition, he suggests an evaluation to
determine the root causes of Mrs. Rs persistent
heartburn.

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