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Ann Epidemiol. Author manuscript; available in PMC 2013 July 26.
Center
3Department
4Division
of Adult and Community Health, National Center for Chronic Disease Prevention and
Health Promotion, Centers for Disease Control and Prevention
5Department
Abstract
PurposeEpidemiologists have long contributed to policy efforts to address health disparities.
Three examples illustrate how epidemiologists have addressed health disparities in the U.S. and
abroad through a social determinants of health lens.
MethodsTo identify examples of how epidemiologic research has been applied to reduce
health disparities, we queried epidemiologists engaged in disparities research in the U.S., Canada,
and New Zealand, and drew upon the scientific literature.
ResultsResulting examples covered a wide range of topic areas. Three areas selected for their
contributions to policy were: 1) epidemiology's role in definition and measurement, 2) the study of
housing and asthma, and 3) the study of food policy strategies to reduce health disparities. While
epidemiologic research has done much to define and quantify health inequalities, it has generally
been less successful at producing evidence that would identify targets for health equity
intervention. Epidemiologists have a role to play in measurement and basic surveillance, etiologic
research, intervention research, and evaluation research. However, our training and funding
sources generally place greatest emphasis on surveillance and etiologic research. Conclusions: The
complexity of health disparities requires better training for epidemiologists to effectively work in
multidisciplinary teams. Together we can evaluate contextual and multilevel contributions to
disease and study intervention programs in order to gain better insights into evidenced-based
health equity strategies.
Carter-Pokras et al.
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Keywords
Introduction
Results of the 2010 U.S. Census suggest that as the growth of Black, Hispanic and Asian
ethnic groups continues to accelerate, there will be a minority majority as early as 2042,
when Hispanics (of any race) will comprise 24 percent of the population, Blacks 15 percent
and Asians 8 percent (2). This majority of racial/ethnic minorities will occur even earlier
(2023) among children and adolescents (2). Addressing their health needs, especially in the
face of growing evidence of continued and severe health disparities for many racial/ethnic
groups, is challenging for health care and public health.
Knowledge of the range and complexity of health disparities has evolved as a result of data
collection on race and ethnicity in epidemiologic surveillance and research (3). In addition,
epidemiologists have long been involved in policy efforts to address health disparities
beyond the conduct, analysis, interpretation and dissemination of health data. These efforts
have included preparation of governmental reports (4-6), managing policy offices (7),
identifying priorities for initiatives (8-10), and providing policy guidance (11).
There are many routes from epidemiologic activity to policy formation: surveillance raises
awareness of an issue, measurement research progressively refines exposures and outcomes,
etiologic research identifies causal relations in natural settings, intervention research pilots
potential actions, and evaluation research considers impacts of policies. The development
and implementation of policies, including laws, regulations, and judicial decrees, includes
advocacy in support of all these efforts. Albert Szent-Gyorgi described three faces of
science as: 1) a way of thinking about things (evidence, objectivity, and a cool head), 2)
the results and their applications, and 3) the scientist's moral code (12). The three faces are
interrelated: from science come results and these may be applied through attendant public
policies.
Epidemiologists wear all three of these faces, and have come to recognize not only the
importance of values in many aspects of professional practice, but also the need for ethical
guidance that regulates our public behavior. Representing the science of public health,
epidemiologists are naturally the most qualified to interpret the epidemiologic studies used
to set public health policy. As Weed has noted, the bioethical principle of beneficence
provides moral justification for advocacy (12).
Epidemiologic research to address health disparities has also evolved, through the four
phases of health disparities research (13). The first phase of health disparities research has
been the identification of the nature and extent of disparities (4). The second phase identified
underlying factors for racial, ethnic and socioeconomic disparities. The third phase, the
development and implementation of interventions (14), increasingly includes
transdisciplinary research, community engagement, and knowledge translation. The fourth
phase encompasses a mixed methods approach to evaluation of comprehensive, multilevel
interventions. Classical epidemiologic approaches and training provide a good basis for
contributions to the first two phases, however, this review highlights a need to expand
Carter-Pokras et al.
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training for epidemiologists to encompass the complexity of health disparities and address
contextual social determinants that contribute to disease, and the foundation of successful
health equity strategies that can reduce and/or eliminate health disparities.
All health behaviors, policies and interventions can impact on disparities. For this reason,
we focus our attention on social determinants of health: policies and interventions that are
targeted at social conditions, rather than medical care or individual behavior change. There
is a long history of interventions on social conditions intended to reduce disparities. For
example, Sara Josephine Baker (18731945) implemented public health interventions
among the poor in New York City, including licensing midwives, encouraging
breastfeeding, providing safe pasteurized milk and school lunches, school-based screening
and maternal education initiatives (15). Likewise, Joseph Goldberger (18741929) was an
advocate for scientific and social recognition of the links between poverty and disease. He
noted that alleviation of poverty improved nutrition, which reduced pellagra in the rural poor
(16).
Social context interventions tend to be non-specific in their impacts, but are often promoted
on the basis of multiple motivations. Because they are upstream they generally have
diverse consequences (intended and unintended). Social context interventions are also
necessarily contextual, and observed effects in one setting often don't generalize well to
others. Finally, social conditions are frequently associated with health outcomes in
observational data, making both causal inference and anticipation of the effects of policy
modifications inherently difficult.
In this review, we provide three examples of how epidemiologists have addressed health
disparities through a social determinants of health lens. To identify examples of how
epidemiology approaches health disparities, we broadly queried epidemiologists engaged in
health disparities research in the US, Canada and New Zealand through listservs, LinkedIn,
and personal communication. Potential cases offered covered a wide range of topics areas,
including asthma, cancer screening and management, cardiovascular disease, data
development, nutrition, food pricing, sexually transmitted infections, HIV/AIDS, child and
adult immunizations, health services, and other topics. We were interested in highlighting
examples that had a social determinants of health focus, had not already been discussed in
the American College of Epidemiology's epidemiology and policy series, and had multiple
applications, either in the U.S. or abroad.
Health policy interventions are enacted among populations to influence outcomes through
various mechanisms. The impacts of population-level policies lead to individual-level
effects measured at the aggregate level (17). Consider the example of a policy designed to
increase physical activity among children attending school-based physical education classes
(18, 19). At the individual level, children may respond to the program by increasing their
physical activity while attending classes. Suppose that each targeted school later reports that
the overall prevalence of childhood obesity has decreased among children attending the
school. It therefore appears that the physical activity policy has influenced childhood obesity
rates. But is the observed change in obesity equal to the causal effect of the intervention?
Could the measured effect be confounded by social or behavioral factors that affect obesity
in the students at some of the schools?
If such factors were to exist, then it would be necessary to adjust for these confounding
variables in a statistical model. Epidemiologists often use a causal diagram to illustrate
relations among factors relevant to an exposure-outcome association, to facilitate
identification of a sufficient set of adjustments to reduce confounding, and to illustrate
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inappropriate adjustment for variables that are not confounders of the exposure effect of
interest. A key criterion that epidemiologists should consider is whether adjusted factors are
affected by the policy as opposed to determinants of policy implementation.
The following example provides an illustration of a graphical model to conceptualize the
influence of a policy intervention on poor living conditions and its subsequent effect on
childhood asthma exacerbations. Because causal diagrams require qualitative determinations
of which factors to include, a critical review of existing evidence is required. Furthermore,
causal diagrams present structural relations using available evidence at a given snapshot in
time. Fortunately, these diagrams can be modified as new evidence becomes available. We
encourage epidemiologists to develop and share their proposed graphical models with other
researchers to promote transparency and to aid in the progressive accumulation of
knowledge. Connecting the graphical model with the statistical modeling approach can
promote a greater understanding of the analytic assumptions, and this can be helpful to the
evaluation process needed to translate scientific findings into policy innovations (20).
Recent research suggests that poor living conditions (e.g., indoor allergens, environmental
tobacco smoke, etc.) exacerbate asthma in children (21). Policies have been enacted to
remediate these environmental factors from households (22). We are interested in
quantifying the magnitude of the effect of the policy intervention on childhood asthma
exacerbations. We recognize that the social environment and its effects on individual and
population health occur at multiple levels and involve dynamic social interactions (23);
therefore we use a simplified graphical model as a tool to illustrate some conditional
dependencies among the interrelated variables in our small universe of measured factors that
influence the outcome (24, 25).
Figure 1 is a graphical representation of the relations among some of the factors that
influence childhood asthma exacerbations. This graph depicts one of many plausible
mechanisms for the sequencing and inter-relations between the policy, the outcome and
some important covariates. This illustrates the dependencies among the many levels in the
data and provides transparency regarding assumptions so that they can be discussed and
critiqued. These factors can be described as social (e.g., socioeconomic status),
environmental (e.g., outdoor air pollution), and genetic variations, and can be defined
concurrently at the individual and population levels. For example, outdoor air pollution
occurs at a population level affecting individual level exposures to pollutants that can lead to
asthma exacerbations (26). Circulating respiratory infections in the community, which occur
throughout the year, increase the occurrence of asthmatic exacerbations in individual
children infected with rhinoviruses, influenza, or other respiratory viruses (27).
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One major role for epidemiology on health disparities policy is through definition,
classification and measurement, fundamental issues that are necessary for all evidencedbased decisions, and for which epidemiology has a long standing tradition of methodologic
development. This work includes exposure assessment, outcome classification, and analysis
of measurement error. On the exposure side, there have been dramatic developments in
recent decades in the assessment of social determinants of health, in both conceptual and
operational terms. Epidemiologists have been at the forefront in public health of refining
conceptually valid and practically implementable measures of constructs such as racism,
segregation, inequality, educational attainment and various forms of wealth and poverty in
health studies (23). Likewise, on the outcomes side, assessment of disparities has evolved to
encompass a wide variety of measures, each with unique advantages with respect to absolute
or relative comparisons and the scaling of the dimension over which the outcomes are
contrasted (38,39). These developments are crucial because the use of different exposure
and outcome measures can generate dramatically different understandings of the
relationships (40). Moreover, common descriptive techniques, such as routine
standardization, can have artifactual influences on the disparity patterns that could sway
policy-makers into an inaccurate perception of changes over time (41). One example that
continues to motivate further work in the area of standardization is the collection of data on
race and ethnicity. Current efforts are underway by HHS as directed by the Affordable Care
Act to improve the monitoring of inequities not only by race but also by ethnicity, primary
language, sex, and disability status. (42-45).
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A concrete example in which the development of exposure indices has influenced policy for
reduction of disparities is the advent of neighborhood quality indices, which summarize a
wide variety of social indicators. For example, the Connecticut Association of Directors of
Health's Health Equity Index assesses numerous domains including economic security,
educational resources, transportation, civic involvement, housing quality, and environmental
quality (46). It is used in policy evaluations to assess community change in relation to
various interventions and policies.
Another example of neighborhood quality indices comes from New Zealand's Social
Reports (Te Prongo Oranga Tangata), which are used by government agencies to monitor
social progress in health disparities (47). These reports have now gained a level of
prominence in central and local government as a tool for surveillance within that country. In
qualitative assessments of the value of this tool for policy makers, senior health officials
from the Ministry of Health asserted that the institution of routine assessment and reporting,
and the availability of content from these reports have assisted in both raising awareness and
stimulating action to address the social determinants of health and improve health equity,
both within and outside the health sector. Amongst civil society actors, too, these reports
have gained currency with health advocacy agencies, health service providers, indigenous
organizations, academic audiences and the media.
Since environmental conditions in the home can exacerbate asthma symptoms, housing
interventions have included home assessment for asthma triggers (e.g., environmental
tobacco smoke, dust mites, outdoor air pollution, cockroach allergen, pets, mold, wood
smoke), provision of products and services to reduce exposure to asthma triggers (e.g.,
mattress cases, chemical methods to reduce dust mites), and asthma education on
identification of asthma triggers and how to reduce exposure. Home-based multi-trigger,
multi-component interventions with an environmental focus are recommended by the Task
Force on Community Preventive Services for children and adolescents, but, not for adults
due to insufficient evidence (52).
Several of the housing intervention programs have clear ties to community needs
assessments. For example, Seattle's King County Department of Public Health conducts a
health survey every three years and analyzes data by region and health planning area.
Stemming from disparities identified in this survey, the Healthy Homes Project aimed to
reduce exposure to indoor asthma triggers among low-income urban children with asthma
(53-55). This project has been translated by Sinai Health Systems in Chicago (56), and
included home visits by community health workers (57, 58).
The eight phases of the Sinai Model for Reducing Health Disparities and Improving Health
included: a community survey (2002-2003), analysis and comparison of results with national
and state data to locate community-level differences, wide dissemination of findings
(2004-2007), partnership with community organizations to prioritize health concerns,
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Carter-Pokras et al.
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decrease access to unhealthy foods (e.g., limit fast-food restaurants); and pricing strategies
that make healthy foods less expensive and unhealthy foods more expensive. For each of
these policies, evaluation is key to documentation of the baseline disparity, and ensuring that
short term and long term outcomes lead to a reduction in health disparities.
Over the last 10 years, a growing number of communities have implemented policies to
increase access to healthy foods with a particular focus on areas of food deserts and food
swamps. Promising polices include providing incentives that allow the installation of
refrigeration units for the sale of fresh fruits and vegetables in convenience or corner stores;
loans and zoning ordinances that promote large grocery stores, farmers markets and corner
stores particularly within food deserts or food swamps; decreasing access to unhealthy foods
through zoning ordinances such as those restricting fast food establishments; and
implementing price strategies that reduce the costs for health foods through consolidated
bids and Electronic Benefit Transfer (EBT)/Supplemental Nutrition Assistance Program
(SNAP), (69, 70).
A number of communities, such as Louisville, Seattle and Philadelphia are working with
local store owners to convert their retail establishments for the sale of fresh fruits and
vegetables and healthy foods. In Charlotte, North Carolina, a farmers market was established
on the grounds of the county health department through a change in the zoning ordinance.
Between 2001 and 2005, the daily consumption of five or more fruits and vegetables among
African Americans in North Carolina increased from 23.1% to 25.3%, while overall statewide consumption of fruits and vegetable decreased from 21.7% to 17.5% (71). The
documented increase in fruits and vegetable consumption among African Americans in
North Carolina at a time when the general trend was in the opposite direction represents
important changes in health behavior, however, additional evaluation is needed to determine
the long term impact of these policies.
Carter-Pokras et al.
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Pricing strategies include enhanced usability of the SNAP, WIC, and EBT at healthier food
vendors, working with grocers in placement and pricing of healthier foods, and consolidated
bid purchase by large organizations such as school districts, large worksites, and local
governments. Consolidated bids allow large purchasers to buy healthier foods at a reduced
price passing the savings onto the consumer. A number of communities are working to
enhance the use of SNAP/EBT cards at healthier vendors including farmers markets and
convenience stores. There are various models for this intervention, for example the policy in
which consumers who purchase $3 of fruits and vegetables receive two additional dollars in
bonus bucks for the purchase of additional fruits and vegetables. While such strategies
seem quite promising, their impact (particularly long term) in relation to health disparities
has not been fully evaluated. Despite the common perception that farmers markets are not
viable for low income populations due to their costs, little research has been conducted
comparing costs between supermarkets and farmers markets (77).
The implementation of food policies, particularly those that are jurisdiction-wide, should be
an effective strategy to reducing disparities in health. These policy approaches should align
with health equity since the entire population is covered by the intervention. Unfortunately,
a jurisdiction-wide approach could inadvertently exacerbate health disparities if differential
barriers exist in the adoption, implementation, and enforcement of the policy by the
community or a sub-population. For example, in 1988 the US Food and Drug
Administration required the fortification of enriched cereal grain products with folic acid
and manufacturers voluntarily added folate to many ready-to-eat cereals. This strategy was
extremely effective in increasing folate levels for women of childbearing age, greatly
reducing the rate of neural tube defects in the US (78). Unfortunately, because of differential
access to folate-rich foods, racial and ethnic disparities in folate remain (78, 79). Integrating
a health disparities assessment into policy planning and implementation can help to ensure
that the implementation of policies lessen, and not widen, health disparities. This includes
the development of milestones that are specifically aimed at advancing health equity,
targeting efforts to sub-populations experiencing greater burden, working with organizations
and in settings to reach underserved populations, and by addressing barriers to and potential
unintended consequences of policy strategies. While some policy approaches may seem
promising for addressing health inequities, they may be insufficient in practice without
strategic actions to alleviate barriers that sub-populations face in terms of the
implementation, enforcement, and sustainability as well as any unintended consequences of
the policy.
Conclusions
NIH-PA Author Manuscript
These three examples illustrate that epidemiologists working in the area of health disparities
are faced with a number of dilemmas. First, the complexity of the topic often demands
innovation in methodological and statistical approaches, including the collection or
identification of data not typically encountered in the academic formation of
epidemiologists. Qualitative data may often be necessary to help understand the culture and
context in which the disease or risk factor occurs in order to determine who and what to
include in surveillance activities. As an example, in the early history of the HIV/AIDS
epidemic it was thought that categories of people, rather than their behaviors, were the
sources of risk. In this way, gay men and Haitians were identified as targets of surveillance,
but only later were the risk behaviors described (e.g., men having sex with men, injection
drug use), as well as their social patterning. Nuanced approaches of interviewing and
studying cultural group norms and behaviors helped epidemiologists to eventually ask better
questions in order to determine and provide guidance on how to reduce risk of infection. It
was also in those qualitative approaches that quantitative questions were included in
Carter-Pokras et al.
Page 10
surveillance, leading to further insights about the socially patterned differences in HIV
incidence by race/ethnicity, gender and sexual orientation (37, 80).
Health disparities researchers face unique challenges in the translation of their findings into
policy, since interventions often involve changes outside the health care enterprise,
including redistribution of resources, affirmative action programs or opposition to actions
that foster social inequality. Epidemiologists, like other health professionals, have
traditionally avoided explicit connections between their scientific findings and social justice
motivations of that work (35, 37). This determination to engage in value free science and let
others determine how best to apply the findings of epidemiologic research to policy is a
long-standing value within the discipline, and the source of much tension in the application
of epidemiology to the study of disparities.
Spasoff (1999) suggested that policy development has five key steps and that epidemiologic
data are central as a guide in each of those steps (81). The first step is the assessment of
population health, in which the role of epidemiology is to define the population and to use
surveillance to identify trends and patterns and to assess risks and health needs. While the
field has demonstrated important contributions to this first step, it has done less to follow up
with the remaining steps which involve producing evidence for successful health equity
interventions. To some extent, this may result from a greater emphasis on individual level
risk factor identification versus evaluation of intervention programs (35, 81). Research on
risk factors may lead more naturally to intervention opportunities if studied from the
perspective of population level factors, particularly as they occur within specific
environments or socially patterned risk clusters and vulnerable sub-populations (82-85).
Health inequalities of interest from a policy perspective are those differences in health that
are judged unnecessary, preventable, and unjust (33, 35). Yet the obvious consequence of
such a definition is that these classifications cannot be based on scientific evidence alone.
Ideology, values, and political perspectives are all necessarily part of the process of
determining these classifications. It is therefore naive to imagine that epidemiologists can
avoid subjectivity in the conduct and interpretation of their work, even while as scientists
they strive to provide the best evidence-based knowledge for effective policy development.
Epidemiologists bring a set of methodological and analytic skills to the last three cycles in
policy development: policy choices, policy implementation and policy evaluation (81).
Assessing potential interventions often requires synthesizing and evaluating evidence across
diverse applications and study designs. Though epidemiologists are often trained in
conducting systematic reviews, they are sometimes less prepared for the type of evaluation
necessary to identify cost effective and efficacious policy interventions. They must embrace
evaluation and dissemination at the beginning of the planning process, and seek funding to
support these tasks. Funders also should consider the need to support all phases of health
disparities research.
Acknowledgments
We gratefully acknowledge comments from participants of the April 2011 American College of Epidemiology
policy committee meeting in St. Louis, Missouri, as well as suggestions of topics for potential cases from health
disparities researchers in response to our queries. We also acknowledge funding support from the American College
of Epidemiology and Washington University in St. Louis (Division of Public Health Sciences) for the April 2011
meeting, and from NIH DA 20826 (Mays) and CDC cooperative agreement 1 U48 DP001929 (Carter-Pokras) for
participation in preparation of this manuscript. The findings and conclusions in this article are those of the authors
and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the
Department of Health and Human Services.
Carter-Pokras et al.
Page 11
AIDS
CARDIA
CBOs
CDC
DALYs
EBT
HIV
HHS
LA
Los Angeles
ng/mL
RBC
REACH
QALYs
SES
Socioeconomic status
SNAP
US
United States
WIC
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Box 1
2.
3.
Policy choices
4.
Policy implementation
5.
Policy evaluation
Carter-Pokras et al.
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Figure 1.
Proposed graphical representation illustrating the dependency assumptions for the influence
of policy and caregiver decision-making to improve poor living conditions (i.e., reduce
indoor allergens) on the occurrence of childhood asthma exacerbations