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HOSPITAL PAKAR SULTANAH FATIMAH, MUAR

MESRA BERSAMA MEMBINA KEUNGGULAN

HOSPITAL PAKAR SULTANAH FATIMAH


MUAR, JOHOR

HOSPITAL
DRUG FORMULARY

Drug Information Unit


Pharmacy Department
Hospital Pakar Sultanah Fatimah

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Foreword
With the exponential advancement in the medical technologies, there is a
challenging need for all healthcare professional to equip themselves with
adequate and updated drug information in order to deliver safe, appropriate and
cost-effective healthcare services to patients.
In conjunction with this, Hospital Pakar Sultanah Fatimah has published its own
Hospital Drugs Formulary with the purpose of achieving the objective above as a
handy reference and to encourage an effective and efficient prescribing practice
in Hospital Pakar Sultanah Fatimah.
The category of prescribers that are authorized to initiate the prescription for the
drug in this formulary is listed as:
A*

= Consultant / Specialist for specific indication only

= Consultant / Specialist

A/KK

= Consultant / Specialist / Family Physicians Specialist

= Medical Officer

= Paramedical Staff

I hope that this Hospital Drugs Formulary will not only serve to improve the
standards of medication prescribing in Hospital Pakar Sultanah Fatimah but also
as an educational reference for new doctors and pharmacists.
Lastly, I would like to express my appreciation to the Drug Information Unit of the
Pharmacy Department HPSF for their time and continuing efforts undertaken in
producing this Hospital Drug Formulary.

DR. SELAHUDDEEN BIN ABD. AZIZ


Director of Hospital Pakar Sultanah Fatimah

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Foreword
The Ministry of Health (MOH) Drug Formulary contains a list of drugs approved
for use in all hospitals or institutions under the Ministry. The Formulary is to
promote rational, cost effective use of drugs whereby newer and more expensive
drugs were introduced in a controlled manner so as to minimize wastage. The
use of the Formulary promotes optimal utilization of funds to purchase drugs.
This Hospital Drug Formulary is adapted from the latest MOH Drug Formulary.
With the large number of new drugs and formulations listed in the Drug
Formulary of the Health Ministry, it is appropriate and timely that guidance is
provided to assist doctors in Hospital Pakar Sultanah Fatimah, Muar in selecting
drugs and formulation that is available in this hospital. A review and update of
this hospital formulary will be done periodically to keep up with the changes in
the availability of drugs, treatment guideline and feedback from the clinical head
of departments. For this Formulary to be successfull, it must be acceptable in our
hospital and used wisely among hospital staff. We welcome feedback from all
hospital staff to improve the quality of this Hospital Drug Formulary.
This Formulary depends heavily on contribution from the Drug Information Unit of
the Pharmacy Department, who generously spend their time and effort to collate
a brief but important document, for the benefit of this hospital. I congratulate
them for their effort.
Last but not least, our sincere appreciation is extended to our Hospital Director,
Dr Selahuddeen Bin Abd. Aziz for his continuous support.

KAMALIAH BT MD SAMAN
Chief Pharmacist
Hospital Pakar Sultanah Fatimah, Muar

ii

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Pharmacy Telephone Directory


Chief Pharmacist

594

Pharmacist U52

639

Outpatient Department
- Counter

105

- Pharmacist

104

Drive Through Pharmacy

636

Inpatient Department
- Counter

616

- Pharmacist

618

Satelit Pharmacy

306

Store
- Hunting line

611

- Pharmacist

593

Cytotoxic Drug Reconstitution (CDR)

617

Total Parenteral Nutrition (TPN)

642

Therapeutic Drug Monitoring (TDM)

481

Ward Pharmacist

615

Drug Information Service (DIS)

638

Manufacturing Unit

634

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Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Table of Contents
Foreword

Pharmacy Telephone Directory

iii

Table of Contents

iv

ALIMENTARY TRACT AND METABOLISM


A01
Stomatological Preparations
A02
Drugs For Acid Related Disorders
A03
Drugs For Functional Gastrointestinal Disorders
A04
Antiemetics and Antinauseants
A05
Bile And Liver Therapy
A06
Laxatives
A07
Antidiarrheals, Intestinal
A10
Drugs Used In Diabetes
A11
Vitamins
A12
Mineral Supplements

1
2
3
3
4
4
4
5
6
8

BLOOD
B01
B02
B03
B05

9
11
12
13

AND BLOOD FORMING ORGANS


Antithrombotic Agents
Antihaemorrhagics
Antianaemic Preparations
Blood Substitutes and Perfusion Solutions

CARDIOVASCULAR SYSTEM
C01
Cardiac Therapy
C02
Antihypertensives
C03
Diuretics
C04
Peripheral Vasodilators
C05
Vasoprotectives
C07
Beta Blockers
C08
Calcium Channel Blockers
C09
Agents Acting On The Renin-Angiotensin System
C10
Serum Lipid Reducing Agents

16
17
18
18
18
19
20
20
22

DERMATOLOGICALS
D01
Antifungals for Dermatological Use
D02
Emollients and Protectives
D03
Preparations For Treatment Of Wounds And Ulcers
D04
Antipruritics, Incl. Antihistamines, Anaesthetics, etc.
D05
Antipsoriatics
D06
Antibiotics and Chemotherapeutics For Dermatological Use
D07
Corticosteroids, Dermatological Preparations
D08
Antiseptics and Disinfectants
D10
Anti-Acne Preparations
D11
Other Dermatological Preparations

23
23
24
24
24
24
25
26
27
27

GENITO URINARY SYSTEM AND SEX HORMONES


G01
Gynaecological Antiinfectives and Antiseptics
G02
Other Gynaecologicals
G03
Sex Hormones and Modulators of the Genital System
G04
Urologicals
iv

28
28
28
30

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS


H01
Pituitary and Hypothalamic Hormones and Analogues
31
H02
Corticosteroids for Systemic Use
31
H03
Thyroid Therapy
32
H05
Calcium Homeostasis
33

ANTIINFECTIVES FOR SYSTEMIC USE


J01
Antibacterial for Systemic Use
J02
Antimycotics For Systemic Use
J04
Antimycobacterials
J05
Antivirals for Systemic Use
J06
Immune Sera and Immunoglobulins
J07
Vaccines

34
40
41
42
45
46

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS


L01
Antineoplastic Agents
L02
Endocrine Therapy
L03
Immunostimulants
L04
Immunosuppressive Agents

47
54
54
55

MUSCULO-SKELETAL SYSTEM
M01
Antiinflammatory and Antirheumatic Products
M02
Topical Products for Joint And Muscular Pain
M03
Muscle Relaxants
M04
Antigout Preparations
M05
Drugs for Treatment of Bone Diseases
M09
Other Drugs For Disorders Of The Musculo-Skeletal System

56
57
57
58
58
58

NERVOUS SYSTEM
N01
Anaesthetics
N02
Analgesics
N03
Antiepileptics
N04
Anti-Parkinson Drugs
N05
Psycholeptics
N06
Psychoanaleptics
N07
Other Nervous System Drugs

59
61
62
65
66
70
73

ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS


P01
Antiprotozoals
P02
Antihelmintics
P03
Ectoparasiticides, Incl. Scabicides, Insecticides and Repellents

74
74
75

RESPIRATORY SYSTEM
R01
Nasal Preparations
R02
Throat Preparations
R03
Drugs for Obstructive Airway Diseases
R05
Cough and Cold Preparations
R06
Antihistamines for Systemic Use
R07
Other Respiratory System Products

76
76
77
80
80
81

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

SENSORY ORGANS
S01
Ophtalmologicals
S02
Otologicals
S03
Ophthalmological and Otological Preparations

82
85
85

VARIOUS
V03
All Other Therapeutic Products
V04
Diagnostic Agents
V07
All Other Non-Therapeutic Products

86
88
88

INDEX

89

APPENDIX
1. Adverse Drug Reactions (ADR) Reporting Form

97

2. Drug Allergy Card Request Form

98

Disclaimer: The Pharmacy Department, Hospital Pakar Sultanah Fatimah shall not be liable for any
loss, damage, death, personal injury or other consequences caused by the use of any information
obtained from this formulary. This information shown is correct at the point of printing.

vi

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

ALIMENTARY TRACT AND METABOLISM

A01 Stomatological Preparations


No Generic Name
Cat Indications
1 Triamcinolone Acetonide
B Oral and perioral lesions
0.1 % In Dental Paste

Dosage
Remark
Apply a thin layer to affected area bd - RM2.90/tube
qid

Benzydamine HCl 0.15 %


Solution (Difflam)

For relief of painful condition Used as a 30 seconds gargle or rinse, RM11.05/


100ml
of the oral cavity
undiluted. ADULT 15 ml.
CHILD < 12 yr 5-15 ml.
ENT, Dental
Uninterrupted treatment should not be
more than 7 days

Thymol Compound
Gargle

For sore throat and minor


mouth inflammation

A02 Drugs For Acid Related Disorders


No Generic Name
Cat Indications
1 Magnesium Trisilicate
C Heartburn, dyspepsia
Mixture

To be gargled tds - qid

RM1.45/ 60ml

Dosage Form
Remark
10-20 ml 3-4 times daily before meals RM0.67/60ml
ADULT 1-2 tablet to be chewed up to RM0.13/tab
6 times a day before meals. CHILD
over 6 years one tablet to be taken bd qid

Magnesium Trisilicate
Tablet

Heartburn, dyspepsia

Sodium Bicarbonate,
Magnesium Carbonate,
Tincture Cardamom
Compound Mixture
(Carminative)

Heartburn, for rapid relief of ADULT 10-20 ml tds


dyspepsia

RM4.87/
120ml

Ranitidine 50 mg/2 ml
Injection

i) Benign gastric/ duodenal


ulceration, reflux
oesophagitis, Zollinger
Ellison Syndrome ii) Stress
ulcer prophylaxis in postoperative and high risk
patients

i) ADULT: Slow IV injection of 50 mg


diluted to 20 ml and given over at least
2 min. May be repeated every 6-8 hrs
or IV infusion at rate of 25 mg/hr for 2
hrs, may be repeated at 6-8 hrs
intervals or IM. CHILD: 1 mg/kg/dose
6-8 hrly. ii) Initial slow IV injection of
50 mg, then continuous infusion of
125-250 mcg/kg/hr

RM0.32/amp

Ranitidine 150 mg Tablet

Ranitidine 300 mg Tablet

i) 150 mg bd (om & on) or 300 mg on


for 4-8 weeks. Maintenance: 150-300
mg on ii) 150 mg bd or 300 mg on for
8-12 weeks iii) 150 mg od or bd iv)
150 mg and may be increased as
necessary to 6 g/day

RM0.13/tab

i) Benign gastric and


duodenal ulcer ii) Reflux
oesophagitis iii) Non-ulcer
dyspepsia iv) ZollingerEllison Syndrome

Omeprazole 20 mg
Capsule

Only for : i)Reflux


oesophagitis
ii)For eradication of
Helicobacter pylori infection
iii)Benign peptic ulcer not
responding to conventional
therapy
iv)Zollinger-Ellison
Syndrome

i)20 - 80 mg od - bd up to 8 - 12 weeks
ii)20 mg bd in combination with any of
the 2 antibiotics (clarithromycin 500
mg bd, amoxicillin 1 g bd or
metronidazole 400 mg bd) for 1 - 2
weeks iii) 20 mg od for 4 - 6 weeks iv)
ADULT: 20 - 120 mg od adjusted
according to the patient's response.
CHILD 0.4 - 0.8 mg/kg/day

RM0.50/caps

Omeprazole 40 mg
Injection

A*

i) Reflux oesophagitis,
i) 40 mg IV once daily when oral
eradication of H. Pylori
therapy is inappropriate ii) 40- 160 mg
infection, benign peptic
by IV in single or divided doses
ulcer not responding to
conventional therapy,
Zollinger-Ellison Syndrome
ii) Endoscopically confirmed
peptic ulcer

RM0.47/tab

RM6.88/vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
9 Pantoprazole 40 mg
Injection

Cat Indications
A* Bleeding peptic ulcer and
acute stress ulceration

Dosage
Remark
40 mg bd until oral administration can RM12.40/vial
be resumed. CHILD not recommended

10

Pantoprazole 40 mg
Tablet

A*

i) Helicobacter pylori
eradication ii) Peptic ulcer
disease iii) Erosive and nonerosive reflux oesophagitis
(GERD and NERD) iv)
Zollinger-Ellison Syndrome
v) Prevention of NSAID
induced gastropathy

i) 40 mg bd in combination with any of


the 2 antibiotics (Clarithromycin 500
mg bd, Amoxicillin 1 g bd or
Metronidazole 400 mg bd) for 1-2
weeks ii) 40 mg od for 2 - 4 weeks iii)
20 - 40 mg om for 4 weeks iv) 40 mg
bd. Maximum: 240 mg daily v) 20 mg
daily. CHILD not recommended

11

Esomeprazole 40 mg
Tablet (Nexium)

A*

i)Gastro-oesophageal reflux i)20mg daily for 4-8 weeks ii)40mg


disease ii)H. pylori
daily for 10 days in combination with
eradication
amoxicillin 1g bd or clarithromycin
500mg bd

RM1.81/tab

Sucralfate 1 g Tablet

i) Benign gastric and


duodenal ulceration ii)
Stress ulcer prophylaxis

RM0.43/tab

12

A03 Drugs For Functional Gastrointestinal Disorders


No Generic Name
Cat Indications
1 Mebeverine HCL 135mg
B Irritable bowel syndrome
Tablet (Duspatalin)

i) 2 g bd or 1 g qid for 4-6 weeks or in


resistant cases up to 12 weeks (max 8
g daily) ii) 1 g 6 times dly (max 8 g
dly). CHILD not recommended

Dosage
135 mg tds

RM0.48/tab

For in-patient
on Ryles
Tube only

Remark
RM0.33/tab

Atropine Sulphate
1mg/ml Injection

i) Reduce vagal
inhibition,salivary and
bronchiol secretion in
anaesthesia
ii) Reversal of excessive
bradycardia
iii) Reversal of effect of
competitive muscle
relaxants
iv) Overdosage with other
compounds having
muscarinic action
v) Organophosphate
poisoning

i) ADULT 300-600 mcg IM/SC 30-60


minutes before anaesthesia or 300600 mcg IV immediately before
induction of anaesthesia
ii) ADULT 0.5-1 mg repeated, every 35 minutes. Max Dosage: 0.04 mg/kg
body weight
iii) ADULT 0.6-1.2 mg before or with
anticholinesterase
iv) ADULT 0.5-1 mg IV/SC, repeated
every 2 hour
v) ADULT 2 mg IV/IM, every 30
minutes according to clinical
response. Cholinesterase reactivator
should be given at the earliest
possible time

RM1.57/amp

Hyoscine N-Butylbromide
20 mg/ml Injection

ADULT 20 - 40 mg.
Max : 40 mg tds - qid.
CHILD 0.5 mg/kg/dose

RM0.69/amp

Hyoscine N-Butylbromide
10 mg Tablet

Gastrointestinal tract and


genito-urinary tract spasm,
dyskinesia of the biliary
system

ADULT 10-20 mg tds.


CHILD 6-12 years: 10 mg tds

RM0.30/tab

Itopride HCl 50 mg Tablet


(Ganaton)

A*

Treatment of
50 mg tds before meal
gastrointestinal symptoms
of functional, non-ulcer
dyspepsia (chronic gastritis)
i.e sensation of bloating,
early satiety, upper
abdominal pain or
discomfort, anorexia,
heartburn, nausea and
vomiting

RM1.14/tab

Borang E

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
6 Metoclopramide HCl 10
mg/2 ml Injection

Metoclopramide HCl 10
mg Tablet

Domperidone 10mg
Tablet

Cat Indications
B i) Dyspepsia, flatulence,
hiatus hernia, peptic
ulceration, reflux
oesophagitis, gastritis,
duodenitis, cholelithiasis,
B
nausea, vomiting
ii) Promote bowel transit
during diagnostic
procedures
B Nausea, vomiting,
dyspepsia, gastroesophageal reflux

A04 Antiemetics and Antinauseants


No Generic Name
Cat Indications
1 Granisetron HCl 3 mg/3
A i) Prevention and treatment
ml Injection
of nausea and vomiting
(Kytril)
associated with
chemotherapy and
radiotherapy
ii) Post-operative nausea
and vomiting

A05 Bile And Liver Therapy


No Generic Name
1 Ursodeoxycholic Acid
250 mg Capsule
(Ursofalk)

Essential Phospholipids
Capsule (Livovid)

A06 Laxatives
No Generic Name
1 Liquid Paraffin

Cat Indications
A Cholestatic liver diseases
(eg. primary biliary cirrhosis,
primary cholangitis etc)

A/KK Nutritional supplement in


liver disorders

Cat Indications
C Constipation

Dosage
Remark
i) ADULT > 20 yr: 10 mg tds. ADULT RM0.35/amp
12 - 20 yr: 5 mg tds. CHILD < 12 yr:
0.12 mg/kg/dose bd - qid
ii) Single dose 5 - 10 minutes before
examination; ADULT and CHILD >
RM0.02/tab
15yr: 10 - 20 mg; CHILD < 15 yr: 0.12
mg/kg/dose bd - qid

Chronic dyspepsia ADULT 10 mg 3


times daily. Acute and subacute
conditions (particularly nausea and
vomiting):ADULT 20 mg 3-4 times
daily

RM0.07/tab

Dosage
Remark
RM62.67/amp
i) ADULT 1-3 mg as an IV bolus not
not less than 30 seconds; maximum 9
mg/day. CHILD over 2 years; single
dose of 10-40 mcg/kg as an IV
infusion; maximum 3 mg/day ii)
ADULT 1 mg by slow IV injection over
30 seconds prior to induction of
anaesthesia

Dosage
Remark
RM2.59/caps
10-15 mg/kg daily in 2 to 4 divided
doses usually for 3 months to 2 years.
If there is no decrease in stone size
after 18 months, further treatment
seems not to be useful
ADULT 1-2 capsules tds with meals

RM0.19/caps

Dosage
Remark
ADULT 10-30 ml on but should not be RM9.28 /kg
taken immediately before going to
bed. CHILD not recommended

Bisacodyl 10 mg
Suppository

i) Constipation ii) Bowel


preparation for radiological
procedures and surgery

i) ADULT and CHILD > 10 yr: 10 mg,


CHILD < 10 yr 5 mg insert rectally ii)
ADULT 10-20 mg, CHILD > 4 yr 5 mg
the following morning before
procedures insert rectally

RM0.27/supp

Bisacodyl 5 mg Tablet

i) Constipation ii) Bowel


preparation for radiological
procedures and surgery

i) ADULT and CHILD > 10 yr 5-10 mg,


CHILD 4-10 yr 5 mg. To be taken at
night for effect on the following
morning ii) ADULT 10-20 mg the night
before procedures, CHILD > 4 yr 5 mg
the night before procedures

RM0.03/tab

Lactulose 3.35 g/5 ml


Liquid

i) Constipation ii) Hepatic


encephalopathy

i) ADULT 15 ml bd adjusted to
patient's need. CHILD 0.5 ml/kg/dose
od or bd ii) 30-50 ml tds-qid, dose
adjusted to produce 2-3 soft stools
daily. CHILD 1 ml/kg/dose tds - qid

RM3.28/
100ml

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Polyethylene Glycol
/Macrogol 4000 Powder
(Fortrans)

Cat Indications
A Bowel cleansing prior to
colonoscopy, radiological
examination or colonic
surgery. Suitable for
patients with heart failure or
renal failure

Dosage
Remark
1 sachet dissolved in 1 L of water. 2-3 RM8.53/ea
L of oral solution are required. When
Borang E
morning surgery is planned, the oral
solution is given in the late afternoon (Nefro)
the day prior. If surgery is scheduled in
afternoon, the oral solution should be
given on the same day for ingestion to
be completed three hours before
surgery

Sodium Biphosphate
16% & Sodium
Phosphate 6% Enema
(Fleet Enema)

Bowel cleansing before


ADULT 133 ml (1 bottle) administered
colonic surgery,
rectally. CHILD more than 2 years half
colonoscopy or radiological the adult dose
examination to ensure the
bowel is free of solid
contents. It is not to be used
for treatment of constipation

RM5.25/
133ml

Monobasic Sodium
Phosphate 48 %, Dibasic
Sodium Phosphate 18%
(Colclean)

Bowel cleansing prior to


colonoscopy, radiological
examination or bowel
surgery

45 ml diluted with half a glass (120 ml)


of water, followed by one full glass
(240 ml) of water to be taken
depending on the time of the
procedure. For morning procedure, 45
ml dilute with half glass of water
should be taken at 7 am and the
second 45 ml at 7 pm on the day
before the procedure. For afternoon
procedure, the first dose should be
taken at 7 pm on the day before and
the second dose at 7 am on the day of
the procedure. Solid food must not be
taken during the preparation period;
clear fluids or water can be taken
liberally. Not recommended for use in
children

RM5.10/90ml

Glycerin 25% & Sodium


Chloride15% Disposable
Enema (Ravin Enema)

Constipation

1 enema as required

RM0.78/ea

Glycerin

As a lubricant and osmotic


dehydrating agent

Apply to area when required

RM8.58/kg

A07 Antidiarrheals, Intestinal


No Generic Name
Cat Indications
1 Nystatin 100,000 units/ml
B Prevention and treatment of
Suspension
candidiasis of the skin and
mucous membranes,
protection against candidas
overgrowth during
antimicrobial /corticosteroid
therapy and as selective
decontamination regimens

Dosage
Remark
RM7.60/ 60ml
NEWBORN: 50,000-100,000 units
daily. CHILD up to 5 years: 100,000 500,000 units qid. CHILD up to 6-12
years and ADULT: 500,000-1,000,000
units tds - qid

Oral Rehydration Salt

Replacement of fluid and


electrolytes loss in
diarrhoea

ADULT: 200-400 ml ( 1-2 sachets ) for


every loose motion. CHILD: 200 ml (1
sachet) for every loose motion. In
severe dehydration 100 ml/kg for 3-4
hrs. INFANT: 1-1.5 times their usual
feed volume (50 ml per stool for small
infant)

RM0.09/sac

Diphenoxylate with
Atropine Sulphate Tablet
(Lomotil)

Acute diarrhoea

ADULT initially 4 tablet followed by 2


tablet qid until diarrhoea is controlled

RM0.08/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
4 Charcoal, Activated 250
mg Tablet

Cat Indications
C i) Diarrhoea and food
poisoning
ii) Reduce absorption of
drugs, plant, inorganic
poison and chemicals in
poisoning cases

Charcoal, Activated 50 g
Granules

Emergency treatment of
acute oral poisoning and
drug overdose

Hydrocortisone Enema
0.1%

Adjunctive treatment for


ulcerative colitis and
proctitis

Salicylazosulphapyridine
(Sulphasalazine) 500 mg
Tablet (Salazopyrin)

A10 Drugs Used In Diabetes


No Generic Name
1 Insulin Recombinant
Synthetic Human, shortacting 100 IU/ml Penfill
and Refill (Humulin R)

A/KK i) Treatment of inflammatory


bowel disease of ulcerative
colitis and Crohn's disease
ii) Rheumatoid arthritis

ADULT 100 mg 1-2 times/day for 2-3


wks. If used for longer than 3 wks,
taper treatment over 2-3 wks

Borang E

i) ADULT, acute attack 1-2 g qid until


remission occurs (if necessary
corticosteroids may also be given),
reducing to a maintenance dose of
500 mg qid, CHILD > 2 yr, acute
attack 40-60 mg/kg daily, maintenance
dose 20-30 mg/kg daily
ii) ADULT, initially; 0.5-1 g/day,
increase weekly to maintenance dose
of 2 g/day in 2 divided doses,
maximun 3 g/day. CHILD > 6 yr,
juvenile rheumatoid arthritis: 30-50
mg/kg/day in 2 divided doses up to a
maximum of 2 g/day

RM0.38/tab

Cat Indications
B Insulin dependent diabetes
mellitus, non insulin
dependent diabetes
unresponsive to treatment to
diet or oral hypoglycaemics,
B
hyperkalaemia to assure
proper utilisation of glucose
and reduce glucosuria in
non diabetic patients
receiving parenteral nutrition
B

Dosage
Dose to be individualised. The
average daily insulin requirement is
between 0.5-1.0 units/kg body weight

Dose to be individualised. The


average daily insulin requirement is
between 0.5 to 1.0 units/kg body
weight

Insulin Recombinant
Synthetic Human,
Intermediate-acting 100
IU/ml Penfill and Refill
(Humulin N)

Insulin Recombinant
Synthetic Human, premixed 100 IU/ml Penfill
and Refill (Humulin 30/70
@ Mixtard)

Insulin Aspart 100 IU/ml


Injection (Novorapid)

A*

Insulin Glargine 300


IU/3ml Injection (Lantus)

A*

Dosage
Remark
RM0.06/tab
i) ADULT 0.5-1 g given tds - qid.
CHILD half adult dose.
ii) Need to be dissolved in liquid (slurry
consistency). ADULT and CHILD > 12
yr: initial 30-100 g or 1-2 g/kg; repeat
initial dose as soon as possible or 2050 g every 2-6 hrs. CHILD > 1-12 yr,
25-50 g or 1-2 g/kg; may repeat half
the initial dose every 2-6 hr as
needed. CHILD to 1 year of age, 1
g/kg; may repeat half the initial dose
every 2-6 hrs as needed. For max.
efficacy administer within 1 hr after
ingestion of toxic compound
RM5.15/50gm
ADULT:Acute poisoning: 50-100g in
suspension. Severe poisoning: 50100g as an initial dose followed by
20g every 4-6 hrs. CHILD: 1g/kg/dose

Diabetic Type 1 and 2 in


patients that still
experienced hypoglycaemia
with use of human insulin

Remark
RM7.79/ea

RM7.79/ea

RM8.25/ea
(Humulin
30/70),
RM6.79/ea
(Mixtard)
RM27.95/ea

Borang E

RM40.74/ea
i) Diabetes mellitus type I in ADULT and CHILD > 6 yr:
adults and child over 6
individualised dose given by SC, od at
KBUK
years ii) Diabetes mellitus
the same time every day
type II in adult

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
6 Metformin HCl 500 mg
Tablet

Cat Indications
B Diabetes mellitus

Glibenclamide 5 mg
Tablet

Gliclazide 80 mg Tablet

Gliclazide 60mg Modified


Release Tablet

10

Metformin 500mg &


Glibenclamide 2.5mg
Tablet (Glucovance)

11

Metformin 500mg &


Glibenclamide 5mg
Tablet (Glucovance)

12

Acarbose 50 mg Tablet

A11 Vitamins
No Generic Name
1 Multivitamin Syrup

Multivitamin Injection
(Parentrovite)

Alfacalcidol 0.25 mcg


Capsule

Alfacalcidol 1 mcg
Capsule

Dosage
500 mg tds or 850 mg bd with food,
max: 3 g dly in 3 divided doses

Range: 2.5 - 15 mg dly (with or


immediately after breakfast). Initially
2.5 mg dly increasing by 2.5 mg
required for metabolic control. Max: 15
mg dly
Diabetes mellitus type 2
Initially 40-80 mg dly. Total daily dose
may vary from 80- 320 mg orally.
Adjust dose according to patient's
individual response
As monotherapy or in
Initially 30 mg daily, adjusted
combination with other oral according to response every 4 wks
antidiabetic agents in type 2 (after 2 wks if no decrease in blood
diabetes in adults when
glucose). Max. 120 mg daily
dietary measures, physical
exercise and weight loss
alone are not sufficient to
control blood glucose

RM0.05/tab

As second-line therapy
1 tablet bd, titrate up to a maximum
when diet, exercise and
daily dose of 2000 mg metformin/20
initial treatment with
mg glibenclamide
sulphonylurea or metformin
do not result in adequate
glycemic control in patients
with type 2 diabetes mellitus

RM0.10/tab

Diabetes mellitus type 2

A/KK Only for treatment of: i) Non Initially 50 mg od, increase to tds up to
insulin dependent diabetes 100 mg tds.
mellitus (NIDDM) when diet Max 200 mg tds
therapy is insufficient ii) Non
insulin dependent diabetes
mellitus (NIDDM) in
combination with existing
conventional oral therapy
where glycaemic control is
inadequate

Cat Indications
C For prevention and
treatment of vitamin
deficiencies
B

Remark
RM0.08/tab

For prevention and


treatment of vitamin
deficiencies

A/KK Treatment of: i) Renal


osteodystrophy in patients
on haemodialysis ii)
Hypoparathyroidism and
pseudohypoparathyroidism
iii) Adjunct to the
A/KK
management of tertiary
hyperparathyroidism iv)
Rickets and osteomalacia v)
Osteoporosis

Dosage
CHILD 5 ml daily or based on
manufacturer

RM0.13/tab

RM0.11/ tab

RM0.11/tab

RM0.15/tab

Remark
RM2.11/
100ml

Initially 2 - 4 pairs IV 4 - 8 hrly,


reducing to 1 pair IV daily. For less
serious cases, 1 pair IV 1 - 2 times
daily or based on individual
requirements

RM32.48/pair

Initial dose ADULT and CHILD > 20kg:


1 mcg dly;
CHILD < 20kg: 0.05 mcg/kg/day.
Maintenance dose : 0.25 mcg to 2
mcg dly

RM0.24/cap

RM1.11/cap

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Alfacalcidol 2 mcg/ml
Drops

Cat Indications
A* Treatment of: i) Renal
osteodystrophy in patients
on haemodialysis ii)
A* Hypoparathyroidism and
pseudohypoparathyroidism
iii) Adjunct to the
management of tertiary
hyperparathyroidism iv)
Rickets and osteomalacia v)
Osteoporosis

Dosage
NEONATES : 0.1 mcg/kg/day

Remark
RM199.80/
bottle

Initial dose : 1 mcg per haemodialysis.


Maximum dose 6 mcg per
haemodialysis and not more than 12
mcg per week

RM11.40/vial

i) 0.25 mcg bd ii) Initial dose 0.25 mcg.


In patients with normal or only slightly
reduced serum calcium levels, doses
of 0.25 mcg eod is sufficient iii) 0.25
mcg/day om iv) ADULT and CHILD 3
years and older : Initially 0.25 mcg/ml.
CHILD less than 3 years : 10 to 15
ng/kg/day

RM0.29/ cap

i) For the prevention or


treatment of Vitamin B1
deficiency syndromes
including beri-beri and
peripheral neuritis
associated with pellagra ii)
Wernicke-Korsakoff
Syndrome

i) Mild to chronic deficiency: 10-25 mg


dly. Severe deficiency: 200- 300 mg
dly ii) 500 mg every 8 hrs for 2 days,
followed by 100 mg bd until patient
can take oral dose

RM0.03/tab

For deficiency or raised


requirement of Vitamin B1,
B6, B12

1 - 3 tablets tds swallowed unchewed

RM0.05/tab

Vitamin B Complex
Tablet

Prophylaxis and treatment


of vitamin B deficiency

1-2 tablets daily

RM0.01/tab

11

Ascorbic Acid 100 mg


Tablet (Vitamin C)

Vitamin C deficiency

ADULT: 100-250 mg od or bd. CHILD:


100 mg tds for 1 week followed by 100
mg daily until symptoms abate

RM0.06/tab

12

Pyridoxine HCl 10 mg
(Vitamin B6)Tablet

i) Pyridoxine-dependent
i) INFANT 4 mg/kg daily for short
convulsions in infancy ii)
periods ii) 100 - 400 mg daily in
Sideroblastic anaemia iii) B6- divided doses iii) ADULT 20 - 50 mg
deficient anaemia in adult
up to 3 times daily iv) Prophylaxis 10
iv) Prophylaxis to peripheral mg daily, therapeutic 50 mg tds v) 20 neuritis in isoniazid therapy 100 mg daily
v) Nausea and vomiting of
pregnancy and irradiation
sickness

RM0.02/tab

13

Riboflavine 3 mg Tablet

For prevention and


treatment of riboflavine
deficiency

RM0.02/tab

Alfacalcidol 2 mcg/ml
Injection

Calcitriol 0.25 mcg


Capsule

Thiamine Mononitrate 10
mg Tablet

Vitamin B1, B6, B12


Tablet (Neurobion)

10

A/KK Treatment of: i)


Postmenopausal
osteoporosis ii) Renal
osteodystrophy in patients
on haemodialysis iii)
Hypoparathyroidism and
rickets iv) Secondary
hyperparathyroidism in renal
failure

CHILD: 2.5-10 mg/day in divided


doses. ADULT: 5-30 mg/day in divided
doses

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

A12 Mineral Supplements


No Generic Name
1 Calcium Gluconate 10%
Injection

Cat Indications
B i) Acute hypocalcaemia
ii) Hypocalcaemic tetany
iii) Cardiac resuscitation

Dosage
i) 1-2 g (2.25-4.5 mmol). CHILD 50
mg/kg
ii) ADULT 1g (2.2 mmol) by slow IV
injection followed by continuous
infusion of 4 g (8.8 mmol) daily
iii) IV or intracardiac injection, 10 ml

A/KK To be used only for


Initial 2.5 g daily and increased up to
elemental calcium
17 g daily
supplementation and
phosphate binding activity in
patients with chronic renal
failure

Remark
RM8.65/amp

RM0.04/tab

Calcium Carbonate 500


mg Tablet

Calcium Lactate 300mg


Tablet

For prophylaxis of calcium


deficiency and treatment of
chronic hypocalcaemia

ADULT 1-5 g dly in divided doses

RM0.15/tab

Potassium Chloride
1g/10 ml Mixture

Potassium depletion

1 g od or bd until serum potassium is


restored

RM13.67/kg

Potassium Chloride SR
600 mg Tablet (Slow-K)

For the treatment and


specific prevention of
hypokalaemia

ADULT: 2-3 tablets dly. Severe


deficiency: 9-12 tablets dly or
according to the needs of the patient

RM0.02/tab

Potassium Citrate 3g/10


ml & Citric Acid Mixture

For systemic or urine


alkalinization

ADULT: 10 ml tds well diluted with


water.
CHILD up to 1 year: 2.5 ml tds;
1-5 years: 5 ml tds;
6 - 12 years: 10 ml tds.
To be taken well diluted with water

RM4.17/
120ml

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

BLOOD AND BLOOD FORMING ORGANS

B01 Antithrombotic Agents


No Generic Name
1 Warfarin Sodium 1 mg
Tablet

Cat Indications
Dosage
B Treatment and prophylaxis Initially 10 mg daily for 2 days.
of thromboembolic disorders Maintenance dose, 3-9 mg daily
according to the INR (taken at the
B
same time each day)

Remark
RM0.40/tab

RM0.42 /tab

Warfarin Sodium 2 mg
Tablet

Warfarin Sodium 3 mg
Tablet

RM0.32 /tab

Warfarin Sodium 5 mg
Tablet

RM0.34 /tab

Heparin 5000 units/ml


Injection

i) Prophylaxis and treatment


of venous thrombosis and
pulmonary embolism.
ii) Treatment of myocardial
infarction and arterial
embolism.
iii) Prevention of clotting in
arterial and heart surgery
and for prevention of
cerebral thrombosis

Heparin Sodium 50 units


in Sodium Chloride
Injection

To maintain patency of
Flush with 5 ml (50 units) every 4
peripheral venous catheters hours or as required

RM0.66 /5ml

Enoxaparin Sodium 20
mg Injection (Clexane)

A*

RM14.65/
0.2ml

Enoxaparin Sodium 40
mg Injection (Clexane)

A*

i) Prevention of Deep Vein


Thrombosis(DVT) especially
in perioperative and high
risk surgical cases
ii) Treatment of DVT
iii) Unstable angina and non
Q wave Myocardial
Infarction

Enoxaparin Sodium 60
mg Injection (Clexane)

A*

10

Clopidogrel 75mg Tablet


(Plavix)

A*

i) By IV inj, LD of 5000 units (10,000


units in severe pulmonary embolism)
followed by continuous infusion of 1525 units/kg/hr. By SC injection (for
DVT) of 15,000 units bd. Small adult
or child, lower LD then, 15-25
units/kg/hr by IV infusion, or 250
units/kg bd by SC injection.
ii) As i), for unstable angina and acute
peripheral arterial occlusion.
iii) Prophylaxis in general surgery, by
SC injection, 5000 units 2 hr before
surgery, then every bd -tds for 7 days
or until patient is ambulant, during
pregnancy (with monitoring), 500010000 units bd. An adjusted dose
regimen may be used for major
orthopaedic surgery or low molecular
weight heparin may be selected

i) Prophylaxis fo DVT especially in


surgical patients: moderate risk, 20 mg
SC approximately 2 hours before
surgery then 20 mg every 24 hours for
minimum 7 - 10 days, high risk (eg
orthopaedic surgery, medical patients,
40mg every 24 hours for at least 6
days until patient ambulant, max 14
days.
ii) Treatment of DVT or pulmonary
embolism, 1.5 mg/kg every 24 hours,
usually for 5 days and until adequate
oral anticoagulation established.
iii) Unstable angina and non-STsegment-elevation myocardial
infarction 1 mg/kg every 12 hours,
usually for 2 - 8 days

Prevention of myocardial
75 mg od
infarct, stroke or established
peripheral arterial disease.
As second/third line
treatment in patients who
are sensitive to
Acetylsalicylic Acid &
intolerant to Ticlopidine

RM12.76/vial

RM19.79/
0.4ml

RM23.95/
0.6ml

RM0.60/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
11 Ticlopidine HCl 250 mg
Tablet

Cat Indications
Dosage
A/KK i) Prevention of thrombotic 250 mg bd to be taken with food
stroke for patients who are
sensitive /intolerant to
Acetysalicylic Acid ii)
Maintenance of coronary
bypass surgery or
angioplasty iii) Maintenance
of patency of access in
patients on chronic
haemodialysis

RM0.07/tab

12

Acetylsalicylic Acid 100


mg, Glycine 45 mg Tablet
(Cardiprin)

Prevention of myocardial
infarct, stroke, vascular
occlusion and deep vein
thrombosis. Transient
ischaemic attacks

13

Dipyridamole 75 mg
Tablet

As an adjunct to oral
75-150 mg tds to be taken 1 hour
anticoagulation/ antiplatelet before meals
therapy in the prophylaxis of
cerebrovascular events

RM0.21/tab

14

Streptokinase 1,500,000
IU Injection

A*

Acute myocardial infarction, Myocardial infarction: 1,500,000 units


acute pulmonary embolism over 30-60 min. Pulmonary embolism:
250,000 units by IV infusion over 30
mins, then 100,000 units every hour
for up to 12-72 hours with monitoring
of clotting factors

RM693.68/
vial

15

Urokinase 6000 IU
Injection

A*

Treatment of
thromboembolic disease
such as mycocardial
infarction, peripheral artery
occlusion, pulmonary
embolism, retinal artery
thrombosis and other
ophthalmologic use

ADULT: Acute pulmonary embolism:


IV loading dose 4400 iu/kg over 10
mins, maintenance 4400 iu/kg/hour for
12 hours. Peripheral vascular
occlusion: infuse 2500 iu/ml into clot at
a rate of 4000 iu/min for 2 hours. This
may be repeated up to 4 times.
Hyphaema: 5000 IU in 2 ml saline
solution is injected and withdrawn
repeatedly over the iris. If residual clot
remains, leave 0.3ml in the anterior
chambers for 24-48 hours to facilitate
futher dissolution

RM38.65/ vial

16

Tenecteplase 10,000 unit


(50 mg) Injection
(Metalyse)

A*

Acute myocardial
reinfarction where
streptokinase is
contraindicated due to
previous streptokinase
induced antibodies.
[Indicated when antibodies
was given > 5 days and <
12 mths]

< 60 kg: 30 mg,


60 - 69 kg: 35 mg,
70 - 79 kg: 40 mg;
80 -90 kg: 45 mg,
90 kg or above: 50 mg.
Administer single IV bolus over 5-10
seconds

RM3352.80/
vial

Dabigatran Etexilate 75
mg Capsule
(Pradaxa)

A*

A*

Following total knee replacement:


Initially ADULT 110 mg (ELDERLY, 75
mg) within 1- 4 hrs after surgery, then
220 mg (ELDERLY, 150 mg) OD
thereafter for 6-10 days Following total
hip replacement: Initially ADULT 110
mg (ELDERLY, 75 mg) within 1- 4
hours after surgery, then 220 mg
(ELDERLY, 150 mg) OD thereafter for
28-35 days

RM4.37/ tab

Dabigatran Etexilate 110


mg Capsule
(Pradaxa)

Prevention of venous
thromboembolic events in
patients who have
undergone total knee
replacement or total hip
replacement surgery

17

18

10

1 tablet dy

Remark
RM0.20/tab

A&E

Orthopedic
(4 pts/mth)
RM4.37/ tab

Orthopedic
(4 pts/mth)

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
19 Dabigatran Etexilate150
mg Capsule
(Pradaxa)

Cat Indications
A* Reduction of the risk of
stroke and systemic
embolism in patients with
non-valvular atrial fibrillation
(AF)

Dosage
Recommended daily dose is 150mg
bd. Therapy should be continued
lifelong. Patients aged > 80 years:
110mg bd. For renal impairment:
150mg bd, no dose adjustment
necessary

20

A*

i) 2.5 mg once daily given by SC,


administered 6 hr following surgical
closure provided homeostasis has
been established. Usual duration of
therapy is 5 to 9 days; for hip fracture
patients, an extended course of up to
24 days is recommended.
ii) ADULT > 18 yr: 2.5 mg od given by
SC, initiated as soon as possible after
diagnosis and continued for up to 8
days or until hospital discharge. If
patient needs to undergo PCI,
unfractionated heparin to be admin as
per local practice protocol, taking into
account the patient's bleeding risk and
time of last dose of fondaparinux.
Fondaparinux may be restarted no
earlier than 2 hr after sheath removal.

Fondaparinux Sodium 2.5


mg/0.5 ml Injection
(Arixtra)

B02 Antihaemorrhagics
No Generic Name
1 Tranexamic Acid 250 mg
Capsule

i) Prevention of venous
thromboembolic events
(VTE) in orthopedic surgery
(e.g. hip fracture, major
knee or hip replacement
surgery), abdominal surgery
in patients at risk of
thromboembolic
complication.
ii) Treatment of unstable
angina or non-ST segment
elevation myocardial
infarction [UA/NSTEMI] in
patients for whom urgent
invasive management (PCI)
is not indicated.
iii) Treatment of ST segment
elevation myocardial
infarction (STEMI) in
patients managed with
thrombolytics or are not
receiving other forms of
reperfusion therapy

Cat Indications
B Haemorrhage associated
with excessive fibrinolysis

Remark
RM4.37/ tab

KBUK
(2 pts)

RM19.55/ea

iii) ADULT > 18 yr: 2.5 mg od; first


dose to be given IV (directly through
an existing IV line or as infusion in 25
or 50 ml of 0.9% saline over 1-2 min),
subsequent doses to be given SC.
Treatment to be initiated as soon as
diagnosis is made and continued up to
a max of 8 days or until hospital
discharge, whichever comes earlier. If
patient needs to undergo non-primary
PCI, unfractionated heparin to be
admin as per local practice protocol,
taking into account the patient's
bleeding risk and time of last dose of
fondaparinux. Fondaparinux may be
restarted no earlier than 3 hr after
sheath removal

Dosage
ADULT: 1-1.5 g (15-25 mg/kg) bd qid. CHILD: 25 mg/kg/day bd - tds.
Menorrhagia (initiated when
menstruation has started), 1 g tds for
up to 4 days; maximum 4 g daily

Remark
RM0.29/cap

Haemorrhage associated
with excessive fibrinolysis

ADULT: Slow IV 0.5-1 g (10 - 15


mg/kg) tds. Continuous infusion at a
rate of 25 - 50 mg/kg daily. CHILD:
slow IV 10 mg/kg/day bd - tds

RM2.77 /amp

Vitamin K deficiency in
neonates

1 mg given by IM or IV

RM1.74/amp

Synthetic Vitamin K1 10
mg/ml Injection

Haemorrhage associated
0.5 - 20 mg by very slow IV at a rate
with hypoprothrombinaemia not exceeding 1 mg per minute
caused by overdose of
anticoagulants

Tranexamic Acid 100


mg/ml Injection

Synthetic Vitamin K1
mg/ml Injection

11

RM 2.08/amp

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Factor VIII Injection

Cat Indications
A Prevention and control of
bleeding in patients with
factor VIII deficiency due to
classical haemophilia A

Dosage
Remark
RM187.50/
Dose varies according to the patient
and the circumstances of the bleeding. vial
i) Mild to moderate: Usually a single
dose of 10-15units/kg. ii) More serious
haemorrhage/minor surgery:Initially 1525 units/kg followed by 10-15 units/kg
every 8 - 12 hrs if required iii) Severe
haemorrhage/major surgery: Initial : 4050 units/kg followed by 20-25 units/kg
every 8-12 hrs.

B03 Antianaemic Preparations


No Generic Name
1 Ferrous Fumarate 200
mg Tablet

Cat Indications
Dosage
Remark
RM0.17/tab
C Prevention and treatment of Prophylactic 200 mg daily.
iron-deficiency anaemias
Therapeutic 200 mg bd. CHILD up to 6
years 80-140 mg bd

Ferric Ammonium Citrate


800 mg/10ml Paed
Mixture

Prevention and treatment of CHILD up to 1 year 5 ml, 1 - 5 years


iron-deficiency anaemias
10 ml, taken well diluted with water

RM66.00/kg

Iron Dextran 50 mg Fe/ml


Injection

Severe iron deficiency


anaemia

An initial test dose of 0.5 ml should be


given over the desired route. For
severe iron deficiency anaemia, 1-2 ml
dly given by deep IM. Dosage is
individualized according to total iron
deficit

RM13.92/amp

Cyanocobalamin 0.1 mg
Injection

i) Prophylaxis of anaemia ii)


Uncomplicated pernicious
anaemia or Vitamin B12
malabsorption

i) Prophylaxis of anaemia: 250-1000


mcg IM every month
ii) Uncomplicated pernicious anaemia
or Vitamin B12 malabsorption: Initial
100 mcg dly for 5-10 days followed by
100-200 mcg mthly until complete
remission is achieved. Maintenance:
100 mcg mthly. CHILD 30-50 mcg
daily for 2 or more wks (to a total dose
of 1-5mg). Maintenance: 100 mcg
mthly to sustain remission

RM1.90/amp

Cyanocobalamin 50 mcg
Tablet

Vitamin B12 deficiency of


dietary origin

ADULT 50-150 mcg daily. CHILD 50105 mcg daily in 1-3 divided doses

RM0.03/tab

Folic Acid 5 mg Tablet

i) For the prevention and


treatment of folate
deficiency states ii) For the
prevention of neural tube
defect in the foetus

i) ADULT initially 5 mg dly for 4 mths


or until haematopoietic response
obtained. Maintenance: 5 mg every 1 7 days depending on underlying
disease CHILD up to 1 yr, 500 mcg/kg
dly; over 1 yr, as adult dose ii) 5 mg
dly starting before pregnancy and
continued through the first trimester

RM0.02/tab

12

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
7 Erythropoietin Human
Recombinant 2000 units
Prefilled Syringes (Eprex)

Cat Indications
A i) Treatment of anaemia
associated with chronic
renal failure. Dialysis
patients who are
haemoglobin less than 8 g
or exhibiting symptoms of
anaemia although
haemoglobin more than 8 g
and pre-transplant cases ii)
Anaemia in cancer (nonmyeloid malignancies) with
concomitant chemotherapy

B05 Blood Substitutes and Perfusion Solutions


No Generic Name
Cat Indications
1 Human Albumin 20%
B i) Acute hypovolemic shock
Injection
ii) Hypoproteinaemia iii)
Neonatal
hyperbilirubinaemia

Dosage
Remark
RM26.80/ea
i) ADULT by IV injection over 1-5
mins, initially 50 units/kg 3 times wkly
adjusted according to response in step
of 25 units/kg 3 times wkly at interval
of at least 4 wks. CHILD initially as for
adult. Maintenance, bodyweight < 10
kg usually 75-150 units/kg 3 times
wkly, 10-30 kg usually 60-150 units/kg
3 times wkly, > 30 kg usually 30-100
units/kg 3 times wkly
ii) ADULT by SC injection (max. 1 ml
per injection site), initially 150 units/kg
3 times wkly, increased if appropriate
rise in haemoglobin not achieved after
4 wks to 300 units/kg 3 times wkly.
Discontinue if inadequate response
after 4 wks at higher dose

Dosage
Remark
i) ADULT 25 g. CHILD 0.6 g/kg body RM105.18/
weight ii) Maximum daily dose is 2g iii) 50ml
1 g/kg before exchange transfusion.
Dose is given at rate of 1 ml of 25%
solution per minute

Modified Fluid Gelatin 4%


Injection (Gelafusine)

For primary volume


ADULT 500 - 1500 ml given as IV
replacement in
infusion
hypovolaemia, perioperative stabilization of the
circulation, haemodilution,
extracorporeal circulation
(haemodialysis and heartlung machine)

RM17.74/
bottle

Hydroxyethyl Starch 6%
Injection

Therapy and prophylaxis of


hypovolaemia and shock in
connection with surgery
trauma, infections and burns

RM27.68/
bottle

Amino Acids 6.5% with


Taurine Injection
(Vaminolact)

Source of amino acids for


Infants: up to 35ml/kg/day
protein synthesis and of
Taurine in infants & children
requiring IV nutrition

RM51.62/
100ml

Amino Acids Injection


(Glamin)

Source of amino acids in


Dose to be individualised. ADULT
patients needing IV nutrition usually 500-2000 ml by IV. ADULT
usual requirement for amino acid: 1-2
g/kg/day

RM147.10/
500ml

Fat Emulsion 20% for IV


Infusion (Intralipid /
Lipofundin)

Source of lipid in patients


needing IV nutrition

RM56.00/
500ml,
RM44.80/
100ml

13

ADULT dly dose up to 20 ml/kg/day.


Normally 500-1500 ml. The rate of
infusion may approach 20 ml/kg/hour
in acute haemorrhagic shock, slower
rates in burns and septic shock.
CHILD < 10 yr 15 ml /kg/hour. Do not
exceed

Dose to be individualised. ADULT


usual lipid requirement 2-3 g/kg/day.
INFANT 0.5-1 g/kg/day

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
7 Dextrose 50 % Injection
(10ml)

Cat Indications
B For parenteral
replenishment of fluid and
B minimal carbohydrate
calories as required by the
clinical condition of the
B
patient

Dosage
According to the needs of the patient

Remark
RM1.16/amp

RM2.57/ bottle

Dextrose 5 % Injection
(500ml)

Dextrose 10 % Injection
(500ml)

10

Amino Acids 15% with


Electrolytes Injection
(Aminoplasma)

Source of amino acids and


electrolytes in patients
needing IV nutrition

Dose to be individualised. ADULT


usual requirement for amino acid 1-2
g/kg/day

RM79/ 500ml

11

Mannitol 10% Injection


(10 g/100 ml)

Cerebral oedema

RM5.43/
500ml

12

Mannitol 20 % Injection
(20 g/100 ml)

0.25- 2 g/kg IV of a 15% to 25%


solution over 30-60 minutes. Safety
and efficacy not established in
children under 12 years of age

13

Sodium Citrate, Citric


Acid Mixture 3 g/10 ml
(Mist Sodium Citrate)

Citrates and citric acid


ADULT 10-20 ml. CHILD up to 1 year
solutions are used to correct 2.5 ml; 6-12 years 10 ml. To be taken
the acidosis of certain renal well diluted with water
tubular disorders to treat
metabolic acidosis for longterm urine alkalinization for
prevention and treatment of
uric acid and calcium kidney
stones and as
nonparticulate neutralizing
buffers

RM19.20/kg

14

Balanced Salt Solution


(Ocusol)

For irrigation during ocular


surgery

RM24.50/
500ml

15

Sodium Bicarbonate,
Citric Acid, Sodium
Citrate and Tartaric Acid 4 g per sachet

For relieving of discomfort in 4-8 g (1-2 sachets) dissolved in a


mild urinary tract infection, glass of cold water 4 times daily as
symptomatic relief of
prescribed
dysuria to enchance the
action to certain antibiotics
especially some
sulphonamides. In gout as
urinary alkalinizers to
prevent cystallisation of
urates

RM0.39/
sachet

For chronic renal disease


requiring dialysis and for
acute renal failure

Dose depending on clinical cases

RM9.45/bag

By slow IV infusion depending on the


deficit or the daily maintenance
requirements. 1 g diluted in 500 ml
normal saline or glucose and given
slowly over 2-3 hours

(Ural)

RM2.65/ bottle

Irrigate as directed

16

Peritoneal Dialysis with


1.5% Glucose Solution

17

Peritoneal Dialysis with


4.25% Glucose Solution

18

Potassium Chloride 1
g/10 ml Injection

For the correction of severe


hypokalaemia and when
sufficient potassium cannot
be taken by mouth

19

Sodium Bicarbonate
8.4% (1 mmol/ml)
Injection

For acceleration of excretion According to the needs of the patient.


in drug intoxication (where In severe shock due to cardiac arrest:
excretion of the drug into
50 ml by IV
the urine is accelerated by
elevated urine pH) and for
acidosis

14

RM4.78/
500ml

RM9.66/bag

RM1.47/amp

RM1.47/amp

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
20 Sodium Chloride (Half
Strength) 0.45% Injection
(500ml)
21 Sodium Chloride 0.9%
Injection
22

Cat Indications
Dosage
B For replenishing fluid and
100 - 1000 ml by IV or according to
for restoring / maintaining
the needs of the patient
the concentration of sodium
C and chloride ions

RM2.41/500ml
RM2.00/250ml
RM1.48/100ml
RM6.00/
500ml

Sodium Chloride 3%
Injection
Sodium Chloride 0.18%
with Dextrose 10%
Injection

24

Sodium Chloride 0.45%


with Dextrose 10%
Injection

25

Sodium Chloride 0.9%


with Dextrose 5%
Injection

RM2.50/
500ml

26

Sodium Chloride 0.18%


with Dextrose 4.23%
Injection

RM2.49/
500ml

27

Sodium Chloride 0.45%


with Dextrose 5%
Injection

RM2.20/
500ml

28

Magnesium Sulphate
50% Injection

Treatment and prophylaxis


of hypomagnesaemia.
Prevention and treatment of
life-threatening seizures in
the treatment of toxemias of
pregnancy (pre-eclampsia
and eclampsia)

RM8.65/5ml
ADULT 5-10 ml by IM. CHILD 20-40
mg/kg as a 20% solution by IM.
Hypomagnesaemia: 0.5-1 mmol/kg up
to 160 mmol magnesium over to 5
days. Eclampsia: IV 4 g over up to 20
minutes followed by IV infusion at rate
of 1 g every hour. Recurrent seizures
may require an additional IV bolus of 24 g (4 g if bw > 70 kg)

29

Potassium Dihydrogen
Phosphate Injection

For treatment of
hypophosphataemia or
phosphate replacement in
parenteral nutrition

Parenteral nutrition: 10 - 20 mmoles of


phosphate daily

30

Phosphate Solution
containing Sodium Acid
Phosphate (1.936g/15 ml)
(Phosphate Sandoz)
Sodium Lactate
Compound
(Hartmanns Solution/
Ringer-lactate)

For supplemental ionic


According to the needs of the patient
phosphorus for correction of
hypophosphataemia

RM3.00/tab

Replacement of
extracellular losses of fluid
and electrolytes, as an
alkaliniser agent

100-1000 ml by IV or according to the


needs of the patient

RM2.43/bottle

A*

Only to be used to cover


daily loss of electrolyte and
trace elements for patient
on parenteral nutrition
Only to be used to cover
daily loss of electrolyte and
trace elements for patient
on parenteral nutrition

10 ml added to 500-1000 ml solution,


given by IV infusion

RM34.70/amp

According to the needs of the patient.


INFANT and CHILD weighing 15 kg or
less: Basal requirements of the
included trace elements are covered
by 1 ml/kg/day to a maximum dose of
15 ml. CHILD weighing 15 kg or more,
a daily dose of 15 ml, should meet
basic trace element requirements.
However, for patients weighing more
than 40 kg the adult preparation trace
element should be used

RM34.70/amp

23

31

32

33

Trace Elements and


Electrolytes (Adult)
Solution
(Addamel)
Trace Elements and
Electrolytes (Paed)
Solution

A*

Acute dilutional
According to the needs of the patient
hyponatraemia
For replenishing fluid and
According to the needs of the patient
energy and for restoring or
maintaining the
concentration of sodium and
chloride ions

Remark
RM2.41/
500ml

(Peditrace)

15

RM2.40/
500ml

RM2.40/
500ml

RM8.65/amp

KPK

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

CARDIOVASCULAR SYSTEM

C01 Cardiac Therapy


No Generic Name
1 Digoxin 500 mcg/2 ml
Injection

Cat Indications
A Heart failure with atrial
fibrillation, supraventricular
arrhythmias (particularly
atrial fibrillation)

Dosage
Remark
Rapid digitilisation: ADULT & CHILD > RM10.87/amp
10 yr, initially 0.75 - 1.5 mg, followed
by 250 mcg 6 hourly until digitilisation
is complete

Rapid digitalisation: 1-1.5 mg in


divided doses over 24 hours; less
urgent digitalisation, 250 - 500 mcg dly
(higher dose may be divided).
Maintenance : 62.5 - 500 mcg dly
(higher dose may be divided)
according to renal function and , in
atrial fibrillation, on heart rate
response; usual range, 125-250 mcg
dly (lower dose may be appropriate in
elderly)
Ventricular tachycardia and 50-100 mg IV as a bolus, repeated
ventricullar fibrillation. To be after 5 minutes if necessary.
diluted before use
Maintenance : 1-4 mg/min by IV
infusion under ECG monitoring

RM0.12/tab

A*

i) Sustained monomorphic
ventricular tachycardias
ii) Preexcited atrial
fibrillation associated with
Wolff-Parkinson White
Syndrome
iii) Reciprocating AtrioVentricular tachycardias
(AVT) associated with WolffParkinson White Syndrome
iv) Supraventricular
tachycardias due to IntraAtrio Ventricular Nodul
Reentry

RM3.70/tab

Amiodarone 150 mg/3 ml


Injection

A*

Arrhythmias when other


Initial infusion of 5mg/kg via large
drugs are contraindicated or venous access over 20-120 mins with
ineffective
ECG monitoring; subsequent infusion
given if necessary according to
response up to a maximum of 1.2 g in
24 hrs

RM13.22/amp

Amiodarone 200 mg
Tablet

A*

Arrhythmias

200 mg tds for 1 week, then reduced


to 200 mg bd for another week.
Maintenance dose, usually 200 mg
daily or the minimum required to
control the arrhythmia

RM0.77/tab
(pack of 30 )
RM0.84
(pack of 50)

Noradrenaline Acid
Tartrate (Norepinephrine
Bitartrate) 4 mg/4 ml
Injection

Septic shock and shock


where peripheral vascular
resistance is low

Infuse and titrate to desired pressure


response. Range: 0.05 - 0.5
mcg/kg/minute

RM7.37/amp

Dopamine HCl 40 mg/ml


Injection

Non-hypovolemic
hypotension

Initial dose 2-5 mcg/kg/min with


incremental changes of 5-10
mcg/kg/min at 10-15 mins intervals
until adequate response is noted. Most
patients are maintained at less than 20
mcg/kg/min. If dosage exceeds
50mcg/kg/min, assess renal function
frequently

RM2.65/amp

Digoxin 0.25 mg Tablet

Lignocaine 100 mg/5ml


Injection

Flecainide Acetate 100


mg Tablet (Trambocor)

Heart failure , with atrial


fibrillation, supraventricular
arrhythmias (particularly,
atrial fibrillation)

16

Ventricular arrhythmias: 100 mg bd,


maximum 400 mg/day (usually
reserved for rapid control or in heavily
built patients), reduced after 3 - 5 days
if possible.
Supraventricular arrhythmias: 50 mg
bd, increased if required to maximum
of 150 mg bd

RM1.16/vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
9 Dobutamine HCl 250
mg/20 ml Injection

10

Cat Indications
A Hypotension and heart
failure

Dosage
Remark
RM8.35/vial
Initial 0.5-1 mcg/kg/min by IV;
maintenance 2.5-20 mcg/kg/min by IV;
titrate according to response;
maximum dose 40 mcg/kg/min
RM0.89/amp
0.5-1 mg given by SC or IM

Adrenaline Acid
(Epinephrine) Tartrate 1
mg/ml Injection
Glyceryl Trinitrate 25
mg/5 ml Injection

Cardiopulmonary
resuscitation

Prophylaxis and treatment


of angina, left ventricular
failure. Not for direct IV
injection.

12

Glyceryl Trinitrate 0.5 mg


Tablet

RM0.08/tab

13

Isosorbide Dinitrate 10
mg Tablet

Prophylaxis and treatment


of angina and left ventricular
failure
Prophylaxis and treatment i) 30 - 120 mg dly in divided doses
for: i) Angina ii) Left
ii) 40 - 160 mg, up to 240 mg if
ventricular failure
required; in acute episodes: 5 - 10 mg
by sublingually

Prophylaxis and treatment


of angina pectoris

RM0.37/cap

A*

For treatment of congenital 0.05 - 0.1 mcg/kg/min by continuous


heart diseases which are
IV infusion, then decreased to lowest
ductus arteriosus dependent effective dose

RM8510/vial

11

(Isordil)
14

15

Isosorbide Mononitrate
50 mg SR Capsule
(Elantan)
Alprostadil 500 mcg/ml
Injection
(Prostin VR)

Initial 5 mcg/min delivered via infusion


pump. Subsequent titration must be
adjusted to clinical situation with dose
increment becoming more cautious as
partial response is seen.
0.5-1 mg sublingually

50 mg daily

RM9.86/amp

RM0.01/tab

16

Adenosine 3 mg/ml
Injection

Rapid conversion of
ADULT: Initially: 3 mg given as a rapid
paroxysmal supraventricular IV bolus (over 2 seconds). Second
tachycardia to sinus rhythm dose: If the first dose does not result
in elimination of the supraventricular
tachycardia with in 1 or 2 minutes, 6
mg should be given also as a rapid IV
bolus. Third dose: If the second dose
does not result in elimination of the
supraventicular tachycardia with in 1-2
minutes, 12 mg should be given also
as a rapid IV bolus

RM64.08/amp

17

Trimetazidine 20 mg
Tablet (Vasteral)

Prophylactic treatment of
20 mg tds
episodes of angina pectoris

RM0.07/tab

18

Ivabradine 5 mg Tablet

A*

Symptomatic treatment of
chronic stable angina
pectoris in patients with
normal sinus rhythm, who
have a contraindication or
intolerance to beta blockers

RM2.51/tab

(Coralan)

C02 Antihypertensives
No Generic Name
1 Methyldopa 250 mg
Tablet

Cat Indictions
B Hypertension

Prazosin HCl 1 mg Tablet

Prazosin HCl 2 mg Tablet

Prazosin HCl 5 mg Tablet

Initial dose 5 mg BD. May increase


dose after 3-4 wks to 7.5 mg BD
depending on response. ELDERLY,
initial dose 2.5 mg BD and titrate to a
maximum of 7.5 mg BD

KBUK

Dosage
Remark
250 mg bd - tds, gradually increased RM0.21/tab
at intervals of 2 or more days,
maximum; 3 g/day. ELDERLY initially
125 mg bd, increased gradually, max;
2 g dly
Initially 0.5 mg bd - tds, the initial dose RM0.10/tab
on retiring to bed at night; increased to
1 mg bd - tds after 3 - 7 days: further RM0.14/tab
increased if necessary to maximum 20
RM0.34/tab
mg daily

Hypertension

17

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Doxazosin Mesylate 4mg
CR Tablet

Cat Indications
A* Benign Prostatic
Hyperplasia

Dosage
4 mg od

Remark
RM0.48/tab

Hydralazine 20mg
Injection

Hypertensive crisis in
pregnancy

i) Slow IV injection, ADULT: 5-10 mg


diluted with 10ml sodium chloride
0.9%. May be repeated after 20-30
minutes if necessary. ii) IV infusion
200-300 mcg/minutes. Maintenance
dose 50-150 mcg/mins

RM12/amp

Minoxidil 5 mg Tablet

A*

Severe hypertension

ADULTS and CHILD > 12 yr: Initially 5


mg dly in single or divided doses
(elderly 2.5 mg). May increase by 5 10 mg dly at intervals of 3 or more
days until optimum control is achieved.
Max: 50 mg dly

RM0.08/tab

C03 Diuretics
No Generic Name
1 Hydrochlorothiazide 50
mg Tablet

Cat Indications
B Diuretic, hypertension

Dosage
Remark
RM0.08/tab
ADULT: Diuretics; 25-200 mg dly.
Hypertension 12.5-25 mg dly CHILD:
Oedema and hypertension; Adjunct; 1
to 2 mg/kg ORALLY dly in single or
two divided doses; Children 2-12 yr
MAX dose, not to exceed 100 mg
ORALLY dly; Infants < 6 mths, may
require doses up to 3 mg/kg ORALLY
dly in two divided doses, Infants up to
2 yrs: MAX dose, not to exceed 37.5
mg ORALLY dly

Frusemide 20 mg/2 ml
Injection

Pulmonary oedema

Initially 20 -40 mg IM or slow IV (rate


not exceeding 4 mg/min). CHILD: 0.5 1.5 mg/kg. Max: 20 mg dly

RM0.29/amp

Frusemide 40 mg Tablet

Pulmonary oedema

ADULT: Initial 40 - 80 mg om if
required, can be increased to a max of
1 g/day in certain cases especially in
chronic renal failure. CHILD : 1 - 3
mg/kg daily

RM0.03/tab

Spironolactone 25 mg
Tablet

i) Diuretic as an adjunct to
the management of
oedematous states
ii) Hypertension

i) Initially 1 - 2 tab dly adjusted


according to response. Max : 4 tabs
daily. ii) 1 -2 tabs dly as a single or
divided dose

RM0.11/tab

C04 Peripheral Vasodilators


No Generic Name
Cat Indications
Dosage
1 Pentoxifylline 400 mg
A/KK Peripheral vascular disease 400 mg bd - tds
Tablet (Trental)
C05 Vasoprotectives
No Generic Name
1 Bismuth Subgallate &
Benzyl Benzoate
Suppository (Anusol)
2

Lignocaine, Aluminium
Acetate, Zinc Oxide &
Hydrocortisone
Suppository (Xyloproct)

Cat Indications
C For relief of pruritus, burning
and soreness in patients
with haemorrhoids and
perianal conditions
B Anorectal pain, pruritis,
inflammation and irritation

18

Remark
RM0.48/tab

Dosage
Remark
Insert 1 suppository night and morning RM0.52/ supp
after bowel movements; do not use for
longer than 7 days
1 suppository to be used od or bd. Not
for prolonged use

RM1.27/supp

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
3 Sodium Tetradecyl
Sulphate 3 % Injection
(Trombovar)

Diosmin 450 mg &


Hesperidin 50 mg Tablet
(Daflon)

C07 Beta Blockers


No Generic Name
1 Propranolol HCL 40 mg
Tablet

Cat Indications
A* Sclerotherapy of
oesophageal varices,
haemorrhoids and varicose
veins

A/KK i) Haemorrhoids
ii) Chronic venous
insufficiency

Cat Indications
B i) Hypertension
ii) Angina
iii) Myocardial infarct
iv) Cardiac arrhythmia
v) Portal hypertension
vi) Migraine
vii) Thyrotoxicosis

Dosage
Remark
0.5-2 mL into the submucosal layer at RM17.50/amp
the base of the oesophageal varix or
the haemorrhoid, several injections
may be given at different sites, max.
total injected 10-15 mL of 1% per
treatment
RM0.37/tab
i) Acute attack: 6 tablets dly for the
first 4 days, then 4 tablets dly in 2
divided doses for 3 days and 2 tablets
thereafter. Chronic: 2 tablets dly ii) 2
tab dly with meals

Dosage
Remark
RM0.10/tab
i) Initially 80 mg bd increased as
required to a usual range of 160 - 320
mg dly. CHILD: Initial doses of 1
mg/kg in divided doses, can be
increased to 2 - 4 mg/kg/day in divided
doses ii) Initial dose of 40 mg bd - tds.
Maintenance 120 - 240 mg dly iii)
40mg qid for 2 - 3 days then 80 mg bd,
beginning 5 - 21 days after infarction
iv) 10 - 40 mg tds - qid v) Initially 40
mg bd. The dose may be increased as
required up to 160 mg bd vi) Initial
prophylaxis dose: 40 mg bd tds. The
dose may be increased at weekly
intervals up to 160 mg dly vii) Adjunct:
10 - 40 mg tds - qid. CHILD:
Arrythmias, thyrotoxicosis: 0.25 - 0.5
mg/kg tds - qid as required
Hypertension: Initially 100 mg to max RM0.17/tab
400 mg dly, Angina: 50 - 100 mg bd tds. Myocardial infarction: 200 mg dly
in divided doses. Arrythmias: 50 mg 300 mg in bd - tds

Metoprolol Tartrate 100


mg Tablet

Hypertension, angina,
myocardial infarction,
arrhythmias

Atenolol 50 mg Tablet

Hypertension, angina
pectoris, myocardial
infarction and arrhythmias

Bisoprolol Fumarate 5 mg
Tablet

RM0.16/tab

Bisoprolol Fumarate 2.5


mg Tablet

Treatment of stable
1.25 mg od to 5 - 10 mg dly
moderate to severe
congestive cardiac failure in
addition to ACEI's and
diuretics

Labetalol HCl 100 mg/20


ml Injection

Hypertension crisis

ADULT: Bolus injection 50 mg IV for at


least 1 min. Max: 200 mg. IV infusion,
dilute 2 amps to 200ml with sodium
chloride and dextrose injection or 5%
dextrose IV infusion, Hypertension of
pregnancy; 20mg per hour doubled
every 30 min to max 160 mg/hr

RM12.60/unit

Labetalol HCl 100 mg


Tablet

Hypertension (including in
pregnancy)

ADULT: 100 mg (50 mg in elderly) dly


with food, increased at intervals of 14
days to usual dose of 200 mg bd, up
to 800 mg bd (3 - 4 divided doses if
higher dose). Max: 2.4 g dly

RM0.29/tab

19

Hypertension and arrythmias; 50 - 100


mg dly, Angina; 100 mg dly,
Myocardial infarction; individualised

RM0.05/tab

RM0.16/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
8 Carvedilol 6.25 mg Tablet

Carvedilol 25 mg Tablet

Cat Indications
A* Treatment of stable
moderate to severe
congestive cardiac failure in
addition to ACEI's and
A* diuretics

C08 Calcium Channel Blockers


No Generic Name
Cat Indications
1 Amlodipine 5 mg Tablet
B Hypertension

Dosage
Remark
RM0.13/tab
3.125 mg bd for 2 weeks, then 6.25
(pack of 100)
mg bd for 2 weeks, then 12.5 mg bd
RM0.07/tab
for 2 weeks then 25 mg bd (titrated up (pack of 28)
to the highest tolerated level)
RM0.13/tab

Dosage
5 mg od. Max: 10 mg

Remark
RM0.02/tab

RM0.04/tab

Amlodipine 10 mg Tablet

Felodipine 5 mg Tablet

A/KK Hypertension

Felodipine 10 mg Tablet

A/KK

Nifedipine 10 mg Tablet

Verapamil HCl 5 mg/2 ml A/KK Supraventricular tachycardia 5 mg by slow IV. The dose can be
Injection
repeated after 5 - 10 mins.
Recommended max. total dose : 15
mg
Verapamil HCl 40 mg
B i) Supraventricular
ADULT: 40 - 80 mg tds - qid. In oral
Tablet
tachyarrhythmias (SVT)
long term therapy, max: 480 mg dly
prophylaxis
ii) angina

RM11.01/amp

Diltiazem HCl 30 mg
Tablet

RM0.22/tab

Initiate at 5 mg od. Usual dose, 5 - 10


mg om

RM0.27/tab

Hypertension

Initial dose of 10 mg bd. Usual range


10 - 30 mg tds. Maximum: 120 - 180
mg per day

Treatment of angina
pectoris in the following
cases: i) inadequate
response or intolerance to
beta-blockers and
Isosorbide Dinitrate ii)
contraindication to betablockers iii) coronary artery
spasm

C09 Agents Acting On The Renin-Angiotensin System


No Generic Name
Cat Indications
1 Captopril 25 mg Tablet
B i) Hypertension
ii) Congestive heart failure
iii) Post-myocardial
infarction
iv) Diabetic nephropathy

Enalapril 5 mg Tablet

Enalapril 10 mg Tablet

Enalapril 20 mg Tablet

RM0.20/tab

i) Hypertension ii)
Congestive heart failure

20

60 mg tds (elderly initially bd);


increased if necessary to 360 mg dly

RM0.02/tab

RM0.12/tab

Dosage
Remark
i) Initially 12.5 mg bd. Maintenance: 50 RM0.07/tab
mg bd - tds, may be increased to max
450 mg/day ii) Initially 6.25 - 12.5 mg
tds, increase after several days to 25 50 mg tds iii) Initially 6.25 mg dly,
gradually increased to 37.5 mg dly in
divided doses iv) 75 - 100 mg dly in
divided doses
i) Initially 5 mg dly, (ELDERLY 2.5 mg
od), usual maintenance dose 10 - 20
mg dly. Maximum: 40 mg/day in 1 - 2
divided doses ii) Initially 2.5 mg dly,
usual maintenance dose 20 mg dly in
1 - 2 divided doses; maximum: 40
mg/day

RM0.15/tab

RM0.03/tab

RM0.06/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Perindopril 4 mg Tablet

Cat Indications
B i) Hypertension ii)
Congestive heart failure iii)
Stable coronary artery
disease

Perindopril 8 mg Tablet

Ramipril 5 mg Tablet

Dosage
Remark
RM0.11/tab
i) 4 mg as single dose, may be
increased to a single 8 mg dose.
ELDERLY: Start treatment with 2 mg
dose. In renal insufficiency, dose
should be adapted according to
creatinine clearance ii) Single starting
oral dose of 2 mg should be increased
to a single 4 mg once BP acceptability RM0.29/tab
has been demonstrated iii) 4 mg od for
2 wks, may be increased to 8 mg od.
ELDERLY: 2 mg od for 1 wk, then 4
mg od for the following wk, may be
increased up to 8 mg od

i) Hypertension and
congestive heart failure
ii) Post-myocardial infarction
iii) Reducing risk of
myocardial infarction, stroke
or cardiovascular death in
diabetics or patients with
increased cardiovascular
risks

i) Initially 2.5 mg od, increased at


intervals of 1-2 wks to MAX 10 mg od
ii) Initially 2.5 mg bd for 2 days then
increased to MAX 5 mg bd
iii) Initially 1.25 - 2.5 mg od, increased
to 5 mg od after 1 wk, MAX: 10 mg od
after 3 wks

RM0.40/tab

Losartan 50 mg Tablet
(Cozaar)

A/KK Patients intolerant of ACE


inhibitors, only in the
treatment of i) Hypertensive
patient with left ventricular
hypertrophy ii) Hypertension
in diabetics with proteinuria
or nephropathy

Hypertension: Usual starting and


maintenance dose: 50 mg od.
Maximum increasing the dose to 100
mg od. Patients with intravascular
volume-depletion starting dose of 25
mg od. Renal protection in Type 2
diabetic patients with proteinuria and
hypertension, starting dose: 50 mg od,
may be increased to 100 mg od based
on blood pressure response

RM1.00/tab

Valsartan 80 mg Tablet
(Diovan)

A/KK Patients intolerant of ACE


inhibitors, only in the
treatment of i) Hypertension
ii) Heart failure iii) Post
myocardial infarction

i) 80 or 160 mg od. May be increased


to 320 mg od ii) 40 mg bd. Uptitration
to 80 and 160 mg bd. Max: 320 mg in
divided dose

RM1.12/tab

10

Irbesartan 300mg Tablet


(Aprovel)

A/KK Hypertension, diabetic


150 mg to 300 mg dly
nephropathy (in patients
who cannot tolerate ACE
inhibitors because of cough)

11

40 - 80 mg a day
Telmisartan 40 mg Tablet A/KK i)Hypertension in patients
(Micardis)
who cannot tolerate ACE
inhibitors because of cough
ii)Reduction of the risk of
myocardial infarction,
stroke, or death from
Telmisartan 80 mg Tablet A/KK cardiovascular causes in
patients > 55 yrs at high risk
(Micardis)
of developing major
cardiovascular events who
are unable to take ACE
inhibitors

12

13

Losartan Potassium 50
mg and
Hydrochlorothiazide 12.5
mg Tablet (Hyzaar)

1 tablet od, may increase to maximum


A/KK Hypertension in patients
dose losartan 100 mg/
who cannot tolerate ACE
inhibitors because of cough, hydrochlorothiazide 25 mg od
hypertensive patient with left
ventricular hypertrophy

21

RM1.36/tab

RM1.03/tab

RM1.22/tab

RM0.98/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
14 Valsartan 80 mg &
Hydrochlorothiazide 12.5
mg Tablet (Co-Diovan)
15 Telmisartan 80mg &
Hydrochlorothiazide
12.5mg Tablet
(Micardis Plus)
16

Amlodipine 5 mg and
Valsartan 160 mg Tablet
(Exforge)

17

Telmisartan 80 mg and
Amlodipine 10 mg Tablet
(Twynsta)

Cat Indications
Dosage
A/KK Hypertension in patients
1 tablet od
who cannot tolerate ACE
inhibitors because of cough
A/KK Hypertension in patients
1 tablet dly
who cannot tolerate ACE
inhibitors because of cough
A*

Essential hypertension in
patients whose blood
pressure is not adequately
controlled by monotherapy

Remark
RM1.10/tab

RM1.24/tab

Doses range from amlodipine besylate RM1.56/tab


5 mg/Valsartan 160 mg to amlodipine
KBUK
besylate 10 mg/valsartan 320 mg
ORALLY od, with dose titration
occuring every 1 to 2 weeks if
necessary; MAX amlodipione besylate
10 mg/valsartan 320 mg

A/KK Treatment of essential


hypertension in adults:
i) Replacement therapy:

Single-pill combination should be


taken once daily. The maximum
recommendation dose is Telmisartan
Patients receiving telmisartan & 80mg/Amlodipine 10mg one tablet per
amlodipine from separate
day.

RM1.21/tab

tablets may instead receive one


tablet containing the same
component doses
ii) Add on therapy: Patients
who BP is not adequately
controlled on telmisartan or
amlodipine monotherapy
iii) Initial therapy: May also be
used as initial therapy in
patients who are likely to need
multiple drugs to achieve their
BP goals

C10 Serum Lipid Reducing Agents


No Generic Name
Cat Indications
Dosage
Remark
1 Simvastatin 10 mg Tablet A/KK Hypercholesterolaemia and 10 - 20 mg od. Maximum: 80 mg daily RM0.10tab
coronary heart disease
RM0.14/tab
2 Simvastatin 40 mg Tablet A/KK intolerant or not responsive
to other forms of therapy
3

Lovastatin 20 mg Tablet

Hypercholesterolaemia and 20 mg od. Maximum: 80 mg daily


coronary heart disease

RM0.06/tab

Pravastatin Sodium 20
mg Tablet

Hypercholesterolaemia and 20 mg od. Maximum: 80 mg daily


coronary heart disease

RM0.42/tab

Atorvastatin 40 mg Tablet

A*

RM0.49/tab

Atorvastatin 20 mg Tablet

A*

Hypercholesterolaemia and 10 mg once daily. Maximum: 80 mg


coronary heart disease
daily
intolerant or not responsive
to other forms of therapy

Gemfibrozil 300 mg
Capsule
(Lopid)

Ezetimibe 10mg tablet


(Ezetrol)

ADULT: 1200 mg/day in 2 divided


doses, 30 minutes before breakfast
and dinner. Dose range from 0.9-1.5 g
daily
i) Co-administration with statins 10 mg od. Not recommended for
for patients who have chronic
children less than 10 years old

RM0.17/tab

heart disease or are chronic


heart disease equivalent or
familial hypercholesterolaemia
with target LDL-C not achieved
by max dose of statins ii)
Monotherapy in patients with
documented biochemical
intolerance to statins

KBUK

A/KK Treatment of
hyperlipoprotinaemias
(TYPES IIA, IIB, III, IV, V)
A*

RM0.31/tab

22

RM3.16/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

DERMATOLOGICALS

D01 Antifungals for Dermatological Use


No Generic Name
Cat Indications
1 Nystatin 100,000 units/g
C Prevention and treatment of
Cream
cutaneous infections caused
by Candida albicans

Dosage
Remark
RM4.40/tube
Apply liberally to affected area bd or
(30gm)
as required. After lesion has
disappeared continue treatment for 10
days to prevent relapses. Nail
infection: Cut nails as short as
possible. Apply cream od until growth
of new nail has set in

Clotrimazole 1 % Cream

Cutaneous candidiasis,
Tinea corporis, Tinea cruris,
Tinea pedis and Tinea
versicolor

Rub in gently onto affected and


surrounding skin bd or tds continuing
for about 2 weeks beyond the
dissapearance of all symptoms

RM1.18/tube
(20gm)

Miconazole 2 % Cream

i) Fungal infections: Tinea


pedis, Tinea corporis, Tinea
capitis and other
dermatophyte infections
caused by Trichophyton and
Epidermophyton species ii)
Antifungal agent that has
been in various candida
infections including vaginal
candidiasis

i) Skin Infection: Apply sparingly and


rub gently onto affected area od - bd
continuing for 10 days after lesions
have healed ii) Apply bd continuing for
10 days after lesions have healed

RM1.10/tube
(15gm)

Ketoconazole 2 %
Shampoo

Resistant dandruff only

Apply twice wkly for 2 - 4 wks.


Prophylaxis: Once every 1 - 2 wks

RM9.14/
120ml

Sodium Thiosulphate
10% Solution

Fungicides. For the


treatment of pityriasis
versicolor

Apply to all affected parts of the body


and face with a brush after a bath od bd or tds

RM22.2/kg

Salicylic Acid 2 % Cream

Apply sparingly to the affected area bd


- tds

Salicylic Acid 2 - 5 %
Ointment

Seborrhoeic dermatitis,
scalp psoriasis and
hyperkeratotic skin
conditions

Salicylic Acid 20 %
Ointment

Plantar warts

Apply sparingly to the affected area bd


-tds. Wash with cleanser bd - tds

Benzoic Acid Compound


Ointment (Whitfields)

Apply sparingly to affected area od bd

RM0.05/gm

11

Terbinafine HCL 250mg


Tab

A*

Tinea infections of
thickened skin of palms and
soles
Fungal infections especially
onchomycosis caused by
dermatophytes

250 mg od for 6 wks for fingernails: 12


wks for toenails

RM1.29/tab

D02 Emollients and Protectives


No Generic Name
Cat Indications
1 Zinc Oxide Ointment
C Skin protective in various
skin conditions such as
nappy rash and eczema

Dosage
Apply tds or as required

RM0.57/30gm

Remark

Paraffin, White Soft

Xerosis and ichthyosis

Apply to the affected area

RM0.40/30gm

Emulsificants Ointment

Xerosis and ichthyosis

Use as a soap and emollient

RM0.53/30gm

Urea (Carbamide) 10 %
Cream

Apply sparingly and rub into affected


area bd - tds and when required after
cleansing skin

RM3.21/tube
(20gm)

Aqueous Cream

Contact irritant dermatitis,


infantile eczemas, acute
and chronic allergic
eczemas, icthyosis,
hyperkeratotic
Dry skin

As a soap or apply to the skin as an


emollient cream

RM0.40/30gm

23

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

D03 Preparations For Treatment Of Wounds And Ulcers


No Generic Name
Cat Indications
1 Protein Free
A Trophic lesions in patients
Haemodialysate 10 %
with arterial occlusive
Jelly (Solcoseryl)
disease and with chronic
venous insufficiency, burn
injuries, impaired wound
healing, decubitus ulcers
and skin ulcer caused by
irradiation
D04 Antipruritics, Incl. Antihistamines, Anaesthetics, etc.
No Generic Name
Cat Indications
1 Calamine Cream
C Prickly heat or insect bites

Dosage
Apply 3 - 5 times daily

Remark
RM18.25/tube
(20gm)

Dosage
Remark
Apply to the affected area as required RM1.33/25gm

Calamine Lotion

Prickly heat or insect bites

Apply to the skin as required and allow


to dry, od - tds

RM5.33/
120ml

Calamine with 5 %
Precipitated Sulphur
Lotion

Acne vulgaris

Apply to the skin as required and allow


to dry, od - tds

RM5.50/ 60ml

D05 Antipsoriatics
No Generic Name
1 Coal Tar 20 % Solution

Cat Indications
Dosage
B Dandruff, seborrhoeic
Use 100 ml in a bath
dermatitis, atopic dermatitis,
eczema and psoriasis

Remark
RM33.06/L

Rub a small amount into the scalp


gently

RM2.90/kg

Massage into wet hair, rinse and


repeat. Use once or twice weekly

RM31.10/
350ml

Only for the treatment of


Psoriasis Vulgaris

Apply to the affected skin lesions bd.


Maintenance therapy may be achieved
with less frequent application. The
wkly dose should not exceed 100 g

RM66.50/
30gm

A*

Resistant plaque psoriasis

Apply once daily up to 4 weeks with


maximum weekly dose of 100g and
maximum treatment area 30% of body
surface

RM94.75/tube
(30gm)

Methoxsalen 10 mg
Capsule

Protection before exposure


to sunlight, psoriasis and
vitiligo

0.2 - 0.6 mg/kg. For repigmentation of


larger lesions (greater than 6 cm sq):
20 mg/day 2 hrs before exposure.
Take with food or milk

RM1.67/cap

Acitretin 10 mg Capsule

A*

Acitretin 25 mg Capsule

A*

Generalised pustular and or ADULT: initially 25-30 mg dly for 2-4


erythrodermic psoriasis,
wks, then adjusted according to
pityriasis rubra pilaris,
response, usually within range 25-50
Darier's Disease,
mg dly for further 6-8 wks (max: 75 mg
Icthyosiform Erythrodermas - dly). CHILD: 500 mcg/kg dly
Bullous and non-bullous
occasionally up to 1 mg/kg dly to a
forms, extensive naevus
MAX 35 mg dly for limited periods
verrucosus, extensive
psoriasis

Cocois Co. Ointment

Tar, Coal Tar and Oleyl


Alcohol Liquid (Polytar)

Calcipotriol 50 mcg/g
Ointment (Daivonex)

A*

Calcipotriol Hydrate 50
mcg/g & Betamethasone
Dipropionate 0.5 mg/g
Ointment (Daivobet)

Scalp psoriasis and severe


seborrhoeic dermatitis

A/KK Dandruff, seborrhoeic


dermatitis and atopic
dermatitis

D06 Antibiotics and Chemotherapeutics For Dermatological Use


No Generic Name
Cat Indications
Dosage
1 Chlortetracycline 3%
B Bacterial skin infections
Apply directly to affected area bd as
Cream (Achromycin)
required for 1 - 2 wks

24

RM3.50/cap

RM7.09/cap

Remark
RM0.50/15gm

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
2 Fusidic Acid 2 % Cream

Cat Indications
Dosage
A Skin infections caused by
Apply to affected area bd - tds
staphylococci, streptococci,
corynebacterium
minutissumun and other
sodium fusidate-sensitive
organisms

Remark
RM3.19/15gm

Neomycin 0.5 % Cream

Infections of the skin due to Apply sparingly to affected area up to


susceptible organisms
tds (For short term use, 1 - 2 wks)

RM2.66/30gm

Mupirocin 2 % Ointment
(Bactroban)

For MRSA infections only

RM4.83/ 15gm

Silver Sulphadiazine 1 %
Cream (SSD)

Prevention and treatment of Burns: Apply 3 mm thick layer twice


infections in severe burns, daily with sterile applicator. Leg ulcer:
leg ulcers where infections apply at least 3 times a wk
may prevent healing and for
the prophylaxis of infections
in skin grafting

RM16.33/kg

Acyclovir 5% Cream

A*

Herpes simplex infections of Apply every 4 hrs for 5 - 10 days


the skin, including initial and
recurrent labial and genital
herpes simplex infections

RM4.40/5gm

D07 Corticosteroids, Dermatological Preparations


No Generic Name
Cat Indications
1 Hydrocortisone 1 %
B Inflammatory and pruritic
Cream
manifestations of
2 Hydrocortisone 1 %
B corticosteroid responsive
dermatoses
Ointment
3

4
5

Clobetasone Butyrate
0.05 % Cream
(Eumovate/ U-Closone))
Clobetasone Butyrate
0.05 % Ointment
Betamethasone 17 Valerate 0.01 - 0.05 %
Cream

ADULT and CHILD: Apply up to tds for


3 - 5 days

Dosage
Apply sparingly to affected area bd tds until condition improve, then
reduce frequency

A/KK Eczema and dermatitis of all Apply up to qid until condition


types
improves, then reduce frequency

Remark
RM0.09/gm

RM0.15/gm

RM8.14/15gm

RM5.15/15gm

A
B

Eczemas, prurigo nodularis, Apply sparingly to affected area bd limited psoriasis in


tds then reduced to od when
appropriate in sites
improvement occurs

RM2.00/15gm

Betamethasone 17 Valerate 0.01 - 0.05 %


Ointment

Eczemas, prurigo nodularis, Apply sparingly to affected area bd limited psoriasis in


tds then reduced to od when
appropriate in sites
improvement occurs

RM2.00/15gm

Betamethasone 17 Valerate 0.1 % Cream

Eczemas, prurigo nodularis, Apply sparingly to affected area bd psoriasis (excluding


tds then reduced to od when
widespread plaque
improvement occurs
psoriasis)

RM22.96/
500gm

Mometasone 0.1%
Cream (Elomet)

A*

Steroid responsive
Apply od to affected areas. Do not use
dermatosis and vitiligo.
in paediatric patients for > 3 wks
Used where a potent steroid
is required for short duration
< 6 wks

RM1.73/15gm

Clobetasol Propionate
0.05 % Cream
(Dermovate)

RM2.22/ 15gm

10

Clobetasol Propionate
0.05 % Ointment
(Dermovate)

Short term treatment only of


more resistant dermatoses
eg. psoriasis, recalcitrant
eczemas, lichen planus,
discoid lupus erythematosus
and other conditions which
do not respond satisfactorily
to less potent steroids

25

Apply sparingly od or bd, changing to


lower potency therapy as soon as
condition is controlled. For mild to
moderate use max for 2 wks. For
moderate to severe Max duration 4
consecutive wks. Max: 50 g/wk

RM3.06/ 15gm

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
11 Fusidic Acid 2 % in
Betamethasone Valerate
0.1 % Cream (Fusicort)

Cat Indications
A/KK Inflammatory dermatosis
where bacterial infection is
likely to occur eg atopic
eczema, discoid eczema,
stasis eczema, seborrhoic
dermatitis, contact
dermatitis, lichen simplex
chronicus, psoriasis, discoid
lupus erythematosus

D08 Antiseptics and Disinfectants


No Generic Name
Cat Indications
1 Acriflavine 0.1% Lotion
C Infected skin, lesions, cuts,
(Flavin)
abrasions, wounds and
burns.

Dosage
Uncovered lesion- Apply bd - tds.
Covered lesions- Less frequent
applications may be adequate

Remark
RM5.10/15gm

Dosage
Remark
Apply undiluted tds to the affected part RM2.78/
120ml
.

Chlorhexidine Gluconate
5% Solution

i) Preoperative skin
disinfection ii) Wounds or
burns iii) Emergency
disinfection of instruments

Povidone Iodine 10%


(eqvt. to 1% iodine)
Solution

Skin operation prior to


Paint the area od or bd and allow to
surgery, in cleansing open dry
wounds, as an antiseptic for
operative wounds infections

RM11.79/
100ml

Benzalkonium 0.01%
Cream (Drapolene)

Prevention and treatment of Wash and dry baby's bottom. Apply by


nappy rash
spreading the cream evenly paying
particular attention to the fold of the
skin, after every nappy change

RM6.14/55gm

Cetrimide 2% Lotion

As shampoo and cleansing


agent

RM33.96/kg

Hydrogen Peroxide 20
vol Solution

Skin disinfection, particularly Hydrogen Peroxide 6% (=approx. 20


cleansing and deodorising vol) shall be dispensed. For cleansing
wounds and ulcers
wounds: 1.5% to 6% solution apply 23 times daily or when nescessary. As
a mouthwash: rinse the mouth for 2-3
minutes with 15ml of hydrogen
peroxide 6% diluted in half a
tumblerful of warm water 2-3 times
daily. Disinfecting cleaned equipment:
immersion for 30 minutes in 6%
solution. As ear drop for removal of
wax: hydrogen peroxide 6% diluted
with 3 parts of water preferably just
before use

RM10.90/L

Benzoin Compound
Tincture

Infected skin, lesions, cuts,


abrasions, wounds and
burns

Apply undiluted to the skin od or bd.


Duration of therapy, may be weeks to
months depending on the infection
being treated

RM57.50/L

Potassium
Permanganate 1:10,000
Solution

Cleansing and deodorising


suppurative eczematous
reactions and wounds

As soaks or wet dressing od - tds or


as required

RM67.00/kg

Alcohol 70% Solution

Use as antiseptic and


disinfectant

Apply to the skin undiluted or when


needed

26

i) & iii) 1 : 10 in 70 % Alcohol


ii) 1 : 100

RM5.22/
120ml

Apply to affected area

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

D10 Anti-Acne Preparations


No Generic Name
1 Tretinoin 0.05 % Cream
(Retin-A)

Cat Indications
A/KK Acne vulgaris and
recalcitrant cases of acne
(comedonal type)
A

Dosage
Remark
Apply thinly to the affected area od or RM5.30/20gm
bd. Avoid exposure to sunlight.
Duration of treatment: 8 - 12 weeks is
RM20.72/
required before any noticeable
15gm
response

Tretinoin 0.01% Gel


(Retin-A)

Benzoyl Peroxide 5 %
Gel

Mild to moderate acne


vulgaris

Isotretinoin 10 mg
Capsule

A*

Isotretinoin 20 mg
Capsule

A*

Only for treatment of i)


Initially: 0.5 mg/kg daily (in one to or
Severe nodulo-cystic acne two divided doses) with food once.
ii) Acne conglobata iii) Acne Maintenance: 0.1 - 1 mg/kg daily
fulminans iv) Severe acne
vulgaris failing conventional
treatment WARNING: THIS
DRUG IS TERATOGENIC

D11 Other Dermatological Preparations


No Generic Name
Cat Indications
1 Selenium Sulphide 2.5% A/KK Dandruff, seborrheic
Shampoo
dermatitis of scalp
(Selsun)

27

Apply sparingly od or bd

RM3.50/tube

RM1.50/tab

RM2.00/tab

Dosage
Remark
Dandruff: apply 5-10 mL topically twice RM9.30/
weekly for 2 weeks, then 1-4 times per 120ml
month, as needed, leave on for 2-3
min, then rinse thoroughly. Seborrheic
dermatitis of scalp: apply 5-10 mL
topically twice weekly for 2 weeks,
then 1-4 times per month, as needed,
leave on for 2-3 min, then rinse
thoroughly

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

GENITO URINARY SYSTEM AND SEX HORMONES

G01 Gynaecological Antiinfectives and Antiseptics


No Generic Name
Cat Indications
1 Clotrimazole 100mg
B Vaginal candidiasis
vaginal Tablet
G02 Other Gynaecologicals
No Generic Name
1 Oxytocin 5 units &
Ergometrine Maleate
0.5mg/ml Injection

Cat Indications
C+ i) Prevention and treatment
of post partum haemorrhage
ii) Management of third
stage of labour

(Syntometrine)

Dinoprostone
(Prostagladine E2) 3mg
Vaginal Tablet
(Prostin E2)
Gemeprost (Prostagladin
E1 Synthetic Analogue) 1
mg Pessary (Cervagem)

Induction of labour by
vagina

Inducing abortion in the first Cervical dilatation: 1 pessary 3 hrly


trimester
before surgery to a max of 5 pessaries
over 24 hrs

Carboprost
Tromethamine 250 mcg.
Injection (Hemabate)

A*

Postpartum haemorrhage
refractory to oxytocin

Levonorgestrel releasing
intrauterine system
20MCG/24 HOURS

A*

i) Contraception (Initial
release rate of 20 mcg/24
hrs).
ii) Idiopathic menorrhagia

(Mirena)

Bromocriptine Mesylate
2.5 mg Tablet

A/KK i) Hypogonadism or
Galactorrhoea
ii) Acromegaly

G03 Sex Hormones and Modulators of the Genital System


No Generic Name
Cat Indications
1 Testosterone 250 mg/ml
A* Only for treatment of male
Injection
infertility, protein deficiency
during convalescence after
surgery and wasting
disorder. In women,
supplementary therapy of
progressive mammary
carcinoma
2

Estradiol Valerate 2 mg
Tablet (Progynova)

Dosage
Remark
i) 1 ml IM, may be repeated after 2 hrs. RM0.69/amp
Should not exceed 3 ml within 24 hrs
ii) For routine management of third
stage of labour, 1 ml IM following
delivery of the anterior shoulder or
immediately after delivery of the child

Dosage
Remark
200 mg od, preferably at bedtime for 3 RM0.30/tab
consecutive days

A*

Oestrogen replacement
therapy - only those who
cannot tolerate Premarin
28

3 mg vaginal tablet to be inserted high


into the posterior formix. A second 3
mg tablet may be inserted after 6-8 hrs
if labour is not established. Max 6 mg

RM58.15/tab

RM135.88/
supp

RM151.00/
ADULT: by deep IM injection; 250
vial
mcg, may repeat at 15-90 minute,
intervals to a total dose of 2 mg (8
doses), followed by subsequent doses
of 250 mcg at intervals of 1.5 to 3.5
hours. Dosage may be increased to
500 mcg/dose if contractility is
inadequate
RM582.83/
One unit intrauterine device to be
inserted into the uterine cavity within 7 unit
days of the onset of menstruation or
Borang E
immediately after first trimester
abortion. Postpartum insertion should
be postponed until 6 wks after
delivery. 1 unit IUD is effective for 5
yrs
RM0.59/tab
i) Initially 1 - 1.25 mg on increased
gradually, usual dose: 7.5 mg dly in
divided doses. Max 30 mg dly ii) 1.25 2.5 mg at bedtime for 3 days and may
be increased by 1.25 - 2.5 mg every 37 days up to 30 mg a day in divided
doses

Dosage
Remark
RM18.04/amp
By IM only. Hypogonadism 250 mg
every 2-3 wks. To maintain an
Borang E
adequate androgenic effect 250 mg
every 3-6 wks. Potency disorders 250
mg every 4 wks. Male climateric
disorders: 250 mg every 3-4 wks.
Repeated 6-8 wks courses at 2-3
months interval
2 mg dly continuously or 21 day
regimen with 1 wk of tablet free
interval

RM0.71/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
3 Conjugated Oestrogens
0.625 mg/g Cream

Cat Indications
A Atrophic vaginitis and post
menopausal atrophic
urethritis

(Premarin)

Conjugated Oestrogens
0.625 mg Tablet

i) Osteoporosis ii) Female


hypoestrogenism iii)
Vasomotor symptoms or
atrophic vaginitis and
urethritis

A*

Complaints resulting from


2.5 - 5mg dly
natural or surgical
menopause and in cases at
high risk for breast
carcinomas where general
hormone replacement
therapy is contraindicated

(Premarin)
5

Tibolone 2.5mg Tablet


(Livial)

Medroxyprogesterone
Acetate 5mg Tablet

(Provera)

Dydrogesterone HCI 10
mg Tablet
(Duphaston)

Estradiol Valerate 2mg &


Norgestrel 0.5mg Tablet

Estradiol 1mg (14 tab) &


Estradiol 1mg with
Dydrogesterone 10mg
(14 tab)
(Femoston 1/10)

i) Secondary amenorrhoea
ii) Abnormal uterine
bleeding due to hormonal
imbalance

A/KK i) Dysmenorrhoea ii)


Endometriosis iii)
Dysfunctional uterine
bleeding (to arrest and to
prevent bleeding) iv)
Threatened abortion v)
Habitual abortion vi) Post
menopausal complaints
(hormone replacement
therapy in combination with
oestrogen)

i) 0.625 mg dly
ii) 0.3 - 1.25 mg dly
iii) 0.3 - 1.25 mg dly

RM0.58/tab

RM2.74/tab

KBUK

RM0.26/tab
i) 5-10 mg dly for 5-10 days. To
produce optimum secretory
transformation 10 mg daily for 10 days
ii) 5-10 mg dly for 5-10 days on day 1521 of menstrual cycle. Optimum
secretory transformation 10 mg dly for
10 days from day 15 of the cycle

i) 10 mg bd from day 5 - 25 of cycle ii)


10 mg bd - tds from day 5 - 25 of the
cycle or continuously iii) To arrest
bleeding :10 mg bd with an oestrogen
once daily for 5 - 7 days, To prevent
bleeding : 10 mg bd with an oestrogen
once daily from day 11 - 25 of the
cycle iv) 40 mg at once, then 10mg
8hrly until symptoms remit v) 10 mg bd
until 20th week of pregnancy vi) 10-20
mg daily during last 12-14 days of
each cycle.

RM1.89/tab

Pre and post menopausal


syndrome, primary and
secondary amenorrhea,
menstrual irregularities.
Deficiency symptoms after
oophorectomy or
radiological castration for
noncarcinomatous disease

Start on the 5th day of menstrual cycle


- 1 tab daily for 21 days then stop for 7
days. If patient forgets dose at usual
time, it should be taken within
following 12 hours

RM1.53/tab

A*

Hormone Replacement
Therapy for women with
disorders due to natural or
surgically induced
menopause with intact uteri

1 tablet daily without pill-free interval,


starting with 1 mg of Estradiol for first
14 days, followed by 1mg Estradiol
with 10 mg Dydrogestrone dly for the
next 14 days

RM1.32/tab

(Progyluton)

Dosage
Remark
RM32.51/
Intravaginally or topically 2 - 4 g dly
14gm
depending on severity of condition.
Total dose not exceeding 4 g.
Administration should be cyclic, with 3
weeks on conjugated oestrogens and
one week off. Oestrogens should be
used for the shortest duration possible
when treating atrophic vaginitis. Every
3 to 6 months attempts should be
made to taper or discontinue therapy
and conjugated oestrogens should be
titrated to give the lowest possible
dosage to control symptoms

29

KBUK

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
11 Clomifene Citrate 50 mg
Tablet

12

13

Cat Indications
A Anovulatory infertility

Danazol 200 mg Capsule A/KK i)Endometriosis and


gynaecomastia
ii)Menorrhagia
iii)Prophylaxis of hereditary
angioedema
Raloxifene HCl 60mg
A* Prevention and treatment of
Tablet
post menopausal
(Evista)
osteoporosis

Dosage
Remark
RM0.49/tab
50 mg dly from 2nd - 6th or 5th - 9th
day of menstrual cycle. Increase dose
gradually by increments of 50 mg if
there is no response until a dosage of
200 mg dly is achieved
i)200-800 mg dly for max of 9 months
ii)200 mg dly for 12 wks ii)400 mg dly.
Reduce to 200 mg dly after 2 months
attack free period

RM1.06/cap

1 tablet daily

RM3.89/tab

KBUK

G04 Urologicals
No Generic Name
1 Tolterodine L-Tartrate ER
4mg Capsule
(Detrusitol)
2

Alfuzosin HCI 10mg


Tablet

Cat Indications
A* Treatment of overactive
bladder with symptoms of
urinary, frequency or urge
incontinence

Treatment of functional
10 mg od pre bed
symptoms related with
benign prostatic hypertrophy
(BPH)

RM1.00/tab

A*

Second line treatment of


400 mcg od
functional symptoms of
benign prostatic hyperplasia
(BPH) in patients who do
not tolerate first line drugs
or when first line drugs are
inappropriate or
contraindicated

RM0.96/tab

RM0.17/tab

A*

(Xatral XL)
3

Tamsulosin HCl 400 mcg


Extended Release Tablet

Dosage
Remark
RM4.68/tab
4 mg od. May decrease to 2 mg od
depending on response and tolerability
Borang E

(Harnal)

Terazosin HCl 2 mg
Tablet

i) Treatment of Benign
Prostatic Hyperplasia.
ii)Hypertension

Finasteride 5 mg Tablet

A*

Treatment and control of


5 mg a day as a single dose. Clinical RM3.53/tab
benign prostatic hyperplasia responses occur within 12 wks - 6
mths of initiation of therapy. Long-term Borang E
administration is recommended for
maximal response

Dutasteride 0.5mg
Capsule
(Avodart)

A*

Benign prostatic hyperplasia 0.5 mg dly


in men with an enlarged
prostate gland

RM3.57/cap

Dutasteride 0.5mg and


Tamsulosin 0.4mg
Capsule
(Duodart)

A*

Combination therapy for the One capsule daily


treatment of moderate to
severe symptoms of BPH
with: i) Large prostate
(>30g) ii) Poor risk or not fit
for surgery iii)Those who are
awaiting their turn for
surgery

RM3.62/cap

(Proscar)

30

i)Initially 1 mg on, increased in a


stepwise fashion to 2 mg, 5 mg or 10
mg od. ii)Initial: 1mg od at bedtime,
Maintenance: 1-5mg od (morning or
evening) or bd. Max: 20-40mg/day

Borang E

KBUK

KBUK
(ikut kouta
pesakit
Dutasteride
sediada)

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS

H01 Pituitary and Hypothalamic Hormones and Analogues


No Generic Name
Cat Indications
Dosage
i) 0.7-1 mg/m2/day or 0.025-0.035
1 Somatropin 8mg (24IU)
A* i) Growth failure due to
inadequate endogenous growth mg/kg/day SC/IM
Injection

Desmopressin 100
mcg/ml Nasal Spray
Desmopressin 0.2mg
Tablet

Oxytocin 10 units/ml
Injection

i) Diabetes Insipidus ii) Primary i) ADULT : 10 - 20 mcg od - bd.


nocturnal enuresis
CHILD: 5 - 10mcg od - bd ii) 10-40 mcg

i)Central diabetes insipidus


ii)Primary nocturnal enuresis
iii)Treatment of nocturia
associated with nocturnal
polyuria in adult

i)ADULT and CHILD: 0.1 mg tds.


RM5.61/tab
Maintenance: 0.3-0.6 mg dly
ii)ADULT and CHILD > 5 yr, 0.2 mg on;
Borang E
withdraw for 1 week for assessment after 3
months iii)Initially 0.1 mg on. May be
increased to 0.2 mg and then to 0.4 mg by
means of weekly increase

Induction of labour

IV: 0.5 - 1 milliunits/minute; gradually


increase dose in increments of 1 - 2
milliunits/minute until desired contraction
pattern is established; dose may be
decreased after desired frequency of
contractions is reached and labor has
progressed to 5 - 6 cm dilation

i) Acromegaly ii) Treatment of


patients with symptoms
associated with gastro-enteropancreatic endocrine tumours
iii) Carcinoid tumours with
features of the carcinoid
syndrome, VIPomas,
glucagonomas,
gastrinomas/Zollinger-Ellison
syndrome, GRFomas,
insulinomas iv) Prevention of
complications following
pancreatic surgery v)
Emergency management of
bleeding gastro-eosophageal
varices in patients with cirrhosis

i, ii and iii) Initially 0.005 - 0.1 mg SC 1 - 2 RM44.77/ amp


times daily, increase gradually up to 0.1 0.2 mg 3 times daily iv) 0.1 mg 3 times
daily for 7 consecutive days, starting on the
day of operation, at least 1 hour before
laparotomy v) 25 mcg/hour for 5 days by
continous IV infusion

(Pitocin)

Octreotide 0.1 mg/ml


Injection
(Sandostatin)

H02 Corticosteroids for Systemic Use


No Generic Name
Cat Indications
1 Fludrocortisone Acetate
A As an adjunct to
0.1 mg Tablet
glucocorticoids in the
management of primary
adrenocortical insufficiency
in Addison's disease and
treatment of salt-losing
adrenogenital syndrome
2

Dexamethasone 0.5 mg
Tablet

RM92.80/
2.5ml

(Minirin)

vial

hormone ii) Growth failure in


ii) 1.4 mg/m2/day or 0.045-0.05 mg/kg/day
girls due to gonadal dysgenesis SC
Borang E
(Turner syndrome) iii) Growth iii) 0.035 mg/kg/day or 1 mg/m2/day SC
failure in short children born
small gestational age (SGA)

(Saizen)

Remark
RM473.50/

Croup, septic shock,


cerebral oedema and
respiratory distress
syndrome including status
asthmaticus

31

RM0.69/amp

Dosage
Remark
Adrenocorticoid insufficiency (chronic): RM1.25/tab
ADULT 1 tablet od. Salt-losing
adrenogenital syndrome: ADULT 1 - 2
tablets dly. CHILD and INFANT 0.5 - 1
tablet dly

0.5 - 9 mg daily, depending upon the


disease being treated. Up to 15 mg
daily in severe disease

RM0.04/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
3 Dexamethasone Sodium
Phosphate 8 mg/2 ml
Injection

Methylprednisolone
Sodium Succinate 0.5 g
Injection

Cat Indications
B Croup, septic shock,
cerebral oedema and
respiratory distress
syndrome including status
asthmaticus

Dosage
Remark
RM0.69/amp
Initially 0.5 - 9 mg IM, IV or infusion
dly, depending upon the disease being
treated

Suppression of
15 - 30 mg/kg dly. Large doses may
inflammatory and allergic
be repeated 4 - 6 hrly for up to 48 hrs
disorders, cerebral oedema,
immunosuppression
treatment of haematological
and oncological disorders,
treatment of shock states
and endocrine disorders

RM43.90/unit

RM0.13/tab

(Solu-Medrol)

Prednisolone 5 mg Tablet

i) Replacement therapy for


primary and secondary
adrenocortical insufficiency
ii) Adrenogenital syndrome
iii) Other therapy

Triamcinolone Acetonide
10 mg/ml Injection

Inflammation of joints,
Smaller joints: 2.5 - 5 mg and larger
bursae and tendon sheaths joints: 5 - 15 mg. Treatment should be
limited to 1 mg/injection site to prevent
cutaneous atrophy

RM5.80/amp

Hydrocortisone 10 mg
Tablet

Glucocorticoid replacement ADULT: 20-30 mg dly in divided


therapy in primary or
doses.
secondary adrenal
CHILD: 10-30 mg dly in divided doses
insufficiencies and long term
management of congenital
adrenal hyperplasia in
children

RM1.03/tab

Hydrocortisone Sodium
Succinate 100 mg
Injection

Conditions responsive to
systemic or local
glucocorticoid injection
therapy especially in
emergencies

RM1.21/vial

H03 Thyroid Therapy


No Generic Name
1 Levothyroxine Sodium
100mcg Tablet

Levothyroxine Sodium
50mcg Tablet

Propylthiouracil 50 mg
Tablet

Cat Indications
B Hypothyroidism

i) 5 - 25 mg daily in divided doses


ii) 10 - 20 mg/m2 dly in divided doses
iii) ADULT: 5 - 60 mg daily. CHILD: 0.5
- 2 mg/kg/day in divided doses every 6
- 8 hrs or as a single dly

Initially 100 - 500 mg IV over 30


seconds to more than 10 mins. Dose
may be repeated at intervals of 2, 4 or
6 hrs

Dosage
ADULT: 1.7 mcg/kg/day orally in a
single daily dose (usual maintenance
dose is 100 - 125 mcg/day 70 kg
adult). CHILD;
0 - 3 months: 10 - 15 mcg/kg/day;
3 - 6 months: 8 - 10 mcg/kg/day;
6 - 12 months: 6 - 8 mcg/kg/day;
1 - 5 years: 5 - 6 mcg/kg/day;
6 - 12 years: 4 - 5 mcg/kg/day;
> 12 years: 2 -3 mcg/kg/day

Palliative treatment of
hypothyroidism as an
adjunct to ameliorate
hyperthyrodism in
preparation for surgical
treatment or radioactive
iodine therapy and in the
management of
thyrotoxicosis crisis

32

CHILD: Initial 5 - 7 mg/kg/day in


divided doses every 8 hrs.
Maintenance: 1/3 to 2/3 of the initial
dose in divided doses every 6-8 hrs.
ADULT: Initial dose: 300 - 450 mg dly
in divided doses every 8 hrs.
Maintenance: 100 - 150 mg dly in
divided doses every 8-12 hrs.

Remark
RM0.10/tab

RM0.13/tab

RM0.17/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
4 Carbimazole 5 mg Tablet

Iodine & Potassium


Iodide Solution (Lugol's
Solution)

H05 Calcium Homeostasis


No Generic Name
1 Calcitonin (Synthetic
Salmon) 200 IU Nasal
Spray (Miacalcic)
2

Calcitonin (Synthetic
Salmon) 100 IU Injection

Cat Indications
B Hyperthyroidism

Dosage
Remark
RM0.07/tab
ADULT: Initially 10 - 60 mg daily in
divided doses. Maintenance: 5 - 20 mg
daily

i) Pre-operative treatment of i) 1 ml daily in divided doses


thyrotoxicosis
ii) 2 - 3 ml daily
ii) Thyrotoxicosis crisis

Cat Indications
A* Osteoporosis

Dosage
200 units daily

RM255.20/kg

Remark
RM143.2/unit

KBUK
A*

Acute hypercalcaemia

(Miacalcic)

33

5 - 10 IU/kg/day SC/IM (in 1 - 2


divided doses) to 400 units every 6 - 8
hours adjusted according to clinical
and biochemical response (no
additional benefit with over 8 units/kg
every 6 hours. 5 - 10 units/kg slow IV
over at least 6 hours

RM38.24/unit

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

ANTIINFECTIVES FOR SYSTEMIC USE

J01 Antibacterial for Systemic Use


No Generic Name
Cat Indications
Dosage
1 Doxycycline 100 mg
B Infections due to susceptible ADULT: 200 mg on the first day
Capsule
organisms
followed by 100 mg dly. Severe
infections: 200 mg dly

Remark
RM0.20/cap

Ampicillin Sodium 500


mg Injection

Treatment of susceptible
bacterial infections (non
beta-lactamase-producing
organisms); meningitis

250 - 500 mg IM/IV every 4 - 6 hrs.


Max: 400 mg/kg/day. Meningitis: 2 g 6
hrly. CHILD: 150 mg/kg/daily IV in
divided doses. Usual children dose <
10 yr, half adult dose

RM2.32/vial

Amoxicillin 250 mg
Capsule

Infections caused by
susceptible strains of gram
positive and gram negative
organisms

ADULT: 250 - 500 mg tds. CHILD: 20 40 mg/kg/day tds

RM0.46/cap

Amoxicillin Trihydrate 125


mg/5 ml Syrup

Infections caused by
susceptible strains of gram
positive and gram negative
organisms

CHILD less than 10 years: 125 - 250


mg 8 hourly. CHILD less than 20 kg:
20 - 40 mg/kg/day in 3 - 4 divided
doses

RM1.20/ 60ml

Bacampicillin 400 mg
Tablet
(Penglobe)

Infections caused by
ampicillin-sensitive gram
positive& gram negative
microorganisms

ADULT: 400 mg bd. Severe infection:


800 mg bd. CHILD > 25 kg: 12.5 - 25
mg/kg bd

RM1.42/tab

Benzylpenicillin 1 mega
unit (600 mg) Injection

i) Infections caused by
susceptible organisms
ii) Infective endocarditis

RM2.32/vial

Benzylpenicillin 5 mega
units (3 g) Injection

i) ADULT: 600 - 1200 mg IM qid,


increased if necessary in more serious
infections. CHILD: 50 - 100 mg/kg dly
IV in 2 - 4 divided doses
ii) ADULT: 7.2 g dly by slow IV
infusion in 6 divided doses

Phenoxymethyl Penicillin
125 mg/5 ml Syrup
(Penicillin V)

Treatment or prophylaxis of CHILD: Up to 1 year: 62.5 mg qid;


infections caused by
1 - 5 years: 125 mg qid;
susceptible organisms
6 - 12 years: 250 mg qid

RM3.75/60ml

Phenoxymethyl Penicillin
250 mg Tablet

i) Treatment or prophylaxis
of infections caused by
susceptible organisms
ii) Prophylactic, rheumatic
fever

RM0.09/tab

(Penicillin V)

i) ADULT: 500 - 750 mg qid. CHILD;


up to 1 yr: 62.5 mg, 1 - 5 yr: 125 mg, 6
- 12 yr: 250 mg qid
ii) ADULT: 125 - 250 mg bd. CHILD:
25 - 50 mg/kg in divided doses every 6
- 8 hrs. Max: 3 g/day

RM4.17/vial

RM5.22/vial

10

Benzathine Penicillin 2.4


mega units Injection (1.8
g)

i) ADULT: 1.2 mega units IM


i) Treatment of mild to
moderately severe
ii) 2.4 mega units wkly for 1 - 3 wks
infections due to Penicillin Gsensitive organisms
ii) Treatment of syphillis

11

Procaine Benzylpenicillin
Aqueous 4 mega units (4
g) Injection

Treatment of infections due ADULT: 300,000 - 900,000 units (300 - RM8.12/vial


to Penicillin G-sensitive
900 mg) IM dly. CHILD: Up to 1 yr:
150 mg IM dly. 1-5 yrs: 300 mg IM dly.
organisms
6-12 yrs: 600 mg IM dly

12

Cloxacillin Sodium 250


mg Capsule

ADULT: 250 - 500 mg qid.


CHILD: 2 - 10 years: 250 mg qid;
< 2 yr: 125 mg qid

RM0.30cap

13

Cloxacillin Sodium 125


mg/5 ml Suspension

Treatment of susceptible
bacterial infections, notably
penicillinase-producing
staphylococci

CHILD 2 - 10 yrs: 250 mg qid,


< 2 yr: 125 mg qid

RM12.76/
100ml

14

Cloxacillin Sodium 250


mg Injection

Cloxacillin Sodium 500


mg Injection

ADULT: 250 - 500 mg qid depending


on type and severity of infection.
CHILD < 20 kg: 25 to 50 mg/kg/day in
equally divided doses qid

RM1.75/vial

15

Treatment of susceptible
bacterial infections, notably
penicillinase-producing
staphylococci infections

34

RM2.32/vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
16 Ampicillin & Sulbactam
250 mg/5 ml Suspension
(Unasyn)

Cat Indications
A Treatment of susceptible
bacterial infections

Dosage
ADULT: 375 - 750 mg bd. CHILD >
30kg- adult dose, < 30 kg: 25 - 50
mg/kg/day in 2 divided doses

Remark
RM10.84/
30ml

17

Ampicillin Sodium 1g &


Sulbactam Sodium
500mg Injection (Unasyn)

Treatment of susceptible
bacterial infections

ADULT: 1.5 - 12 g/day in divided


doses tds-qid. MAX: 4 g Sulbactam.
CHILD: 150-300 mg/kg/day tds-qid.
Prophylaxis of surgical infections: 1.5 3 g at induction of anaesthesia. May
be repeated tds-qid.
NEONATES: First wk of life,
75mg/kg/day in divided doses bd

RM3.25/vial

18

Ampicillin & Sulbactam


375 mg Tablet (Unasyn)

Treatment of susceptible
bacterial infections

ADULT & CHILD > 30 kg: 375 - 750


mg bd. Max: 3 g daily

RM1.17/tab

19

Amoxicillin & Clavulanate A/KK Infections caused by


228 mg/5 ml Syrup
susceptible organisms
(Augmentin)

Moderate infections: CHILD 7 - 12


year: 10 ml, 2-6 yr: 5 ml.
Severe infections: 2-6 yr: 10 ml

RM8.14/ 70ml

20

Amoxicillin 1g &
Clavulanate K 200mg
Injection (Augmentin)

21

Amoxicillin 500 mg &


Clavulanate 125 mg Tab
(Augmentin)

22

Piperacillin 4g &
Tazobactam 500mg
Injection (Tazocin)

A*

Febrile neutropenia, lower


respiratory tract infection
and severe sepsis

~Adult and children > 12 yrs: 4.5 g tds


~Renal insufficiency: CrCL 20 - 80
ml/minute: 4.5 g tds. CrCL <
20ml/minute: 4.5 g bd
~Neutropenia adult and children > 12
yrs, > 50 kg: 4.5 g qid in combination
with aminoglycosides
~Children with normal renal function &
< 50kg: 90 mg/kg qid in combination
with aminoglycosides

RM12.43/vial

23

Cephalexin Monohydrate
250 mg Capsule

i) Respiratory tract infection,


urinary tract infection ii)
Complicated, recurrent or
chronic infections, bronchitis
iii) Pneumonia

i) 250 mg qid
ii) 250 - 500 mg qid
iii) 1 - 1.5 g tds or qid.
Max: 6 g/day

RM0.15/tab

24

Cephalexin Monohydrate
125 mg/5 ml Syrup

Respiratory tract infections, CHILD: 25 - 100 mg/kg/day qid.


ear, nose and throat
Max: 4 g dly
infections, urinary tract
infections, obstetric and
gynaecologic infections

RM1.45/60ml

25

Cefuroxime Axetil 125


mg/5 ml Suspension

Infections caused by
susceptible organisms

RM28.36/
50ml

CHILD < 3 mth: 30mg/kg bd.


Infections caused by
3 mth - 12 yr: 30mg/kg tds-qid.
susceptible organisms.
Respiratory tract, skin, soft ADULT: 1.2 g by IV or intermittent
infusion tds-qid
tissue, GUT infection,
septicaemia, peritonitis, postoperative infection &
osteomyelitis

A/KK Infections due to betaADULT & CHILD > 12 yr: Mild to


lactamase producing strain moderate infections: 625 mg bd.
where amoxicillin alone is
Severe infections: 1 g bd
not appropriate. Respiratory
tract, skin, soft tissue, GUT
infection, septicaemia,
peritonitis, post-operative
infection & osteomyelitis

35

30 mg/kg/day in 2 divided doses

RM4.36/vial

RM2.72/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
Cat Indications
26 Cefuroxime Axetil 125 mg A/KK Upper respiratory tract,
Tablet
GUT, skin & soft tissue
infections, urinary tract
(Zinnat)
infection (UTI),
pyelonephritis

Dosage
ADULT: 250 mg bd ;
UTI: 125 mg bd.
CHILD:125 mg bd.
Max 250 mg/day

27

Cefuroxime Sod 750 mg


Injection

Infections caused by
susceptible organisms,
surgical prophylaxis

ADULT: 750 mg tds - qid IM or IV.


Severe infections: 1.5 g tds - qid IV.
CHILD: 30 - 100 mg/kg/day in 3 - 4
divided doses.
Surgical prophylaxis: 1.5 g IV

RM6.26/vial

Infections due to gramnegative bacteria

ADULT: 1 g bd (up to 12 g/day in


severe cases). CHILD: 50 - 180
mg/kg/day in 4 - 6 divided doses

RM6.90/vial

Severe gram negative


bacterial infections

RM11.07/vial

Infections caused by
susceptible organisms

ADULT: 1 g tds or 2 g bd.


In severe infections: 2 g tds.
CHILD: 25 - 150 mg/kg/day in 2 - 3
divided doses
ADULT: 1-2 g od. Severe infection: 4 g
bd. INFANT & CHILD, 3 wks - 12 yrs:
20-80 mg/kg dly. CHILD > 50 kg: adult
dose. NEONATE up to 2 wks: 20-50
mg/kg dly, not to exceed 50 mg/kg

Infections due to gramnegative bacteria

ADULT: 1 - 2 g bd IM or IV. By IV,


adult dose may be doubled.
Max: 16 g daily in divided doses.
CHILD & INFANT: 50 - 200 mg/kg/day
in 2 - 4 divided doses.
NEONATE < 8 days: 50 - 200
mg/kg/day bd

RM5.22/vial

i) Treatment of infections
ADULT: 1 - 2 g bd.
due to multi-drug resistance CHILD: 40 - 80 mg/kg/day
pathogens producing Blactamase
ii) Treatment of infections
caused by Acinetobacter
species

RM15.70/vial

A*

Febrile neutropenia,
septicaemia, lower
respiratory tract infection,
urinary tract infection, skin
and skin structure
infections, gynaecologic and
intra-abdominal infections

RM11.51/vial

A*

i) Emperical treatment for


ADULT: 0.5 - 1g tds,
presume infections in
CHILD: 10 - 20 mg/kg tds (except
patients (adult and children) meningitis 40 mg/kg)
with febrile neutropenia,
used as monotherapy or in
combination with anti-virals
or antifungal agent
ii) Septicaemia
iii) Serious infections in
renal impaired patients

(Zinacef)
28

Cefotaxime 1 g Injection
(Claforan)

29

Ceftazidime 1 g Injection
(Fortum)

30

Ceftriaxone 1g Injection
(Rocephin)

31

Cefoperazone Sodium 1
g Injection
(Cefobid)

32

Cefoperazone 500mg &


Sulbactam 500mg
Injection
(Sulperazon)

33

Cefepime 1 g Injection
(Maxipime)

34

Meropenem 1g Injection

Remark
RM0.82/tab

36

ADULT: 1 - 2 g bd for most infections.


For severe infections including febrile
neutropenia: 2 g tds.
CHILD: 25 - 50 mg/kg tds

RM9.04/vial

RM48.60/vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
35 Imipenem 500 mg &
Cilastatin 500 mg
Injection
(Tienam)

Cat Indications
A* Severe infections caused by
susceptible pathogens
especially useful in
infections involving ESBL
organisms. Not to be used
for prophylaxis

36

Trimethoprim 300 mg
Tablet

37

Sulphamethoxazole 200
mg & Trimethoprim 40
mg/5ml Suspension
(Bactrim)

38

Sulphamethoxazole 400
mg & Trimethoprim 80
mg Injection

(Bactrim)

39

Sulphamethoxazole 400
mg & Trimethoprim 80
mg Tablet

Dosage
Remark
Based on type or severity of infection, RM29.23/vial
susceptibility of pathogen(s) and
patient condition including body weight
and renal function.
ADULT: 1-2 g/day in 3-4 divided
doses. Max: 4 g/day or 50 mg/kg/day.
Infusion rate: < 500 mg dose: over 2030 mins, > 500 mg: dose over 40-60
mins.
CHILD: 15 - 30 mg/kg/dose, infusion
at 6-12 hrly intervals depending on
age. Max: 2 g/day

ADULT: 200 mg dly in 1 or 2 divided RM1.66/tab


Treatment of urinary tract
infections due to susceptible doses or 300 mg dly as a single dose.
pathogens
Acute infection: 200 mg bd.
CHILD: 6 - 12 yrs: 100 mg bd;
6 mths - 5 yrs: 50 mg bd.
6 wks - 5 mths: 25mg bd
Infections caused by
CHILD < 12 yrs: TM 6 mg & SMZ 30 RM35.65/
susceptible pathogens
mg/kg/day, divided into 2 equal doses. 60ml
CHILD > 12 yrs: Standard dose: 10 ml
diluted and infused bd. Severe
infections: 15 ml diluted and infused
bd
i) Severe or complicated
i) ADULT: 960 mg bd increased to
RM11.60/ea
infections when oral therapy 1.44g bd in severe infections. CHILD:
is not feasible
KPK
36 mg/kg daily in 2 divided doses
ii) Treatment and
increased to 54 mg/kg/day in severe
prophylaxis of pneumocystis infections
carinii pneumonia (PCP) in ii) Treatment: ADULT & CHILD > 4
immunocompromised
wks: 120 mg/kg/day PO/IV infusion in
patients
2 - 4 divided doses for 14 days.
Prophylaxis: ADULT: 960 mg od or
960 mg on alternate days (3 times a
week) or 960 mg bd on alternate days
(3 times a wk).
CHILD 6 wks - 5 mths: 120 mg bd on
3 consecutive days or 7 days per wk;
6 mths - 5 yrs: 240 mg;
6-12 yrs: 480 mg

i) Severe or complicated
infections due to susceptible
infection ii) Treatment and
prophylaxis of pneumocystis
carinii pneumonia (PCP) in
immunocompromised
patients

i) ADULT: 1 - 3 tablets bd ii)


Treatment: ADULT & CHILD > 4 wks:
120 mg/kg/day in 2 - 4 divided doses
for 14 days. Prophylaxis: ADULT: 960
mg od or 960 mg on alternate days (3
times a wk) or 960 mg bd on alternate
days (3 times a wk). CHILD; 6 wks - 5
mths: 120 mg bd on 3 consecutive
days or 7 days per wk; 6 mths - 5 yrs:
240 mg; 6 - 12 yrs: 480 mg

(Bactrim)

RM0.09/tab

40

Erythromycin
Ethylsuccinate 400 mg/5
ml Suspension

Treatment of susceptible
bacterial infections

CHILD: mild to moderate infection: 30 - RM4.98/60ml


50 mg/kg/day in equally divided doses
every 6 hrs. For more severe infection
this dose may be doubled. Doses may
be given bd - tds a day

41

Erythromycin
Ethylsuccinate 400 mg
Tablet (EES)

Treatment of susceptible
bacterial infections

ADULT: 400-800 mg bd.


CHILD: 30-50 mg/kg/day in 2-4
divided doses

37

RM0.26/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
42 Erythromycin
Lactobionate 500 mg
Injection

Cat Indications
A* Only for treatment of i)
certain forms of meningitis
ii) septicaemia not
responding to usual
antibiotics iii) mycoplasma
pneumonia iv) infection with
gram-positive organisms
(e.g. tetanus, streptococcal
infection) associated with
Penicillin allergy, only when
oral erythromycin cannot be
given

43

Clarithromycin 250 mg
Tablet

A*

Only for i) treatment of


i) 250-500 mg bd. Up to 6-14 days
complicated respiratory tract ii) 500 mg bd with omeprazole &
infection not responding to amoxicillin. Up to 2 wks
standard macrolides
ii) eradication of
Helicobacter pylori infection

RM2.12/tab
(pack of 30)
RM0.45/tab
(pack of 100)

44

Azithromycin 500mg
Injection

A*

RM49.70/vial

45

Azithromycin 250 mg
Tablet

A*

Only for treatment of severe 500 mg IV as a single dly dose for a


atypical pneumonia
minimum of 2 days followed by 500
mg oral dose as a single dly dose to
complete a 7-10 days course
i) Treatment of complicated i) 500 mg dly for 3 days
respiratory tract infection not ii) 1 g as a single dose
responding to standard
iii) 1 g wkly
macrolides
ii) Adult treatment of
uncomplicated genital
infections due to Chlamydia
trichomatis or susceptible
Neisseria gonorrhoea
iii) Prophylaxis against
Mycobacterium avium
complex in patients with
advanced HIV

46

Clindamycin HCl 300 mg


Capsule

A*

i) Skin and soft tissue


infections, bone& joint
infections
ii) Cerebral toxoplasmosis
iii) Children less than 8
years old:Treatment and
prophylaxis of malaria in
combination with quinine, as
an alternative to doxycline

i) ADULT: 150-300 mg qid; up to 450


mg qid in severe infections;
CHILD: 3 - 6 mg/kg qid
ii) 600 mg qid for 6 wks
iii) 10mg/kg bd, in combination with
quinine. The combination to be given
for 7 days

RM0.62/cap

47

Clindamycin Phosphate
150 mg/ml Injection

A*

i) Skin and soft tissue


infections, bone & joint
infections
ii) Cerebral toxoplasmosis

RM27.50/ea

48

Streptomycin Sulphate
1 g Injection

Tuberculosis

i) ADULT: 0.6 - 2.7 g dly (in 2 - 4


divided doses); up to 4.8 g dly; CHILD
> 1 mth, 15 - 25 mg/kg/day or 350
mg/m2/day in 3 - 4 divided doses ii)
1200 mg qid for 3 wks followed by 300
mg orally qid for another 3 wks
0.5 - 1 g IM of Streptomycin base daily
or at longer intervals, cumulative dose
should not exceed 100 g

49

Gentamicin 7.5 mg
Beads

Treatment of chronic
7.5 - 22.5 mg chains to fill affected
osteomyelitis of postcavity
traumatic, post-operative or
hematogenous origin

38

Dosage
Remark
ADULT& CHILD: 15 - 20 mg/kg/day in RM13/vial
divided doses by IV infusion or
intermittently by slow IV over 1 hr at
intervals not more than 6 hrly.
Max: 4 g/day

RM1.17/tab

RM1.04/vial

RM35/unit

KPK

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
50 Gentamicin Sulphate
80 mg/2 ml Injection

Cat Indications
Dosage
B Infections due to susceptible ADULT: 3 - 5 mg/kg/day tds IM or IV.
organisms
CHILD up to 2 wks: 3mg/kg bd;
2 wks - 12 yrs: 2 mg/kg tds

51

Amikacin 500 mg/2 ml


Injection

52

Ofloxacin 100 mg Tablet

(Tarivid)

53

54

Ciprofloxacin 250 mg
Tablet
(Ciprobay)
Ciprofloxacin 200 mg /
100 ml Injection

Remark
RM0.52/amp

Infections due to susceptible ADULT: (IM or IV): 15 mg/kg/day bdorganisms


tds for 7 - 10 days. Max: 1.5 g/day.
CHILD: 15 mg/kg/day bd - tds. Max:
1.5 g/day. Neonates: Initial LD of 10
mg/kg followed by 7.5 mg/kg/day bd.
Max: 15mg/kg/day
i) As second-line treatment i) 400 mg/day
of leprosy
ii) 400 mg bd
ii) As second-line treatment iii) 200 mg bd
for tuberculosis and
multidrug resistant
tuberculosis (MDR-TB)
iii) Sequential therapy for
UTI and pyelonephritis

RM6.72/amp

Treatment of infections due


to susceptible bacterial
strains
Treatment of infections due
to susceptible bacterial
strains

ADULT: 125-750 mg bd. Acute


gonorrhoea: a single dose of 250 mg

RM0.06/tab

ADULT uncomplicated infections:200


mg/day; acute gonorrhoea and acute
uncomplicated cystitis in women can
be treated with a single infusion of 100
mg.Other infections: 400-800 mg/day

RM10.80/vial

(Ciprobay)

RM0.22/tab

55

Vancomycin HCl 500 mg


Injection

A*

Only for the treatment of


Slow IV infusion, ADULT: 500 mg over
MRSA and CAPD peritonitis at least 60 mins qid or 1 g over at least
100 mins bd.
NEONATE up to 1 wk, 15 mg/kg
initially, then 10 mg/kg bd.
INFANT 1 - 4 wks, 15 mg/kg initially
then 10 mg/kg tds.
CHILD > 1 mth, 10 mg/kg qid

RM8.70/vial

56

Fusidic Acid 500 mg


Injection

A*

Treatment of severe
staphylococcal infections
especially Methicillin
Resistant Staphylococcus
aureus (MRSA). To be used
in combination therapy only

ADULT : 500 mg tds diluted to 250 500 ml infused slowly over 2 hrs.
Max: 2 g dly.
CHILD and INFANT : 20 mg/kg/day
divided into 3 equal doses infused
slowly over 2 - 4 hrs

RM60.32/vial

57

Fusidic Acid 250 mg


Tablet

A*

ADULT: 500 mg tds, skin and soft


tissue infection: 250 - 500 mg bd

RM1.49/tab

58

Metronidazole 500
mg/100 ml Injection
(Flagyl)

Treatment of infections
caused by susceptible
organisms especially
Staphylococcal infections
including Methicillin
Resistant Staphylococcus
aureus (MRSA)
Anaerobic infections

ADULT: 500 mg IV infusion tds.


CHILD: 7.5 mg/kg tds

RM2.52/bottle

59

Colistin (Polymyxin E)
1,000,000 unit Injection

Adults > 60kg: 1-2 million units tds.


Max: 6 million units in 24 hrs.
Children < 60 kg : 50 000 to 75 000
units/kg/day in 3 divided dose.
Dosage adjustment required in renal
impairment.

RM18.08/vial

Acinetobacter CBC sepsis


multiresistant (even to
sulperazone)

(Colistimethate)

39

KPK

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

J02 Antimycotics For Systemic Use


No Generic Name
Cat Indications
1 Amphotericin B 50 mg for
A Systemic fungal infections
Injection

Ketoconazole 200 mg
Tablet

Fluconazole 50 mg
Capsule

Fluconazole 2 mg/ml
Injection

Itraconazole 100 mg
Capsule

A*

Dosage
Remark
RM22.02/vial
ADULT: 0.25 mg/kg/day by IV
infusion, gradually increase if tolerated
to 1 mg/kg/day. Max in severe cases:
1.5 mg/kg dly or on alternate days. For
neonates, lower doses are
recommended
i) 200 mg with meal od for 10 days
ii) 200 - 400 mg dly for 4 wks - 6 mths
iii) 200 - 400 mg dly for 6 - 12 mths.
Max 400 mg dly

RM0.24/tab

i) Oropharyngeal
candidiasis, atrophic oral
candidiasis associated with
dentures, other candidal
infections of mucosa
ii) Tinea pedis, corporis,
cruris, versicolor and dermal
candidiasis
iii) Invasive candidal &
cryptococcal infections
(including meningitis)
iv) Prevention of relapse of
cryptococcal meningitis in
AIDS patients after
completion of primary
therapy
v) Prevention of fungal
infections in
immunocompromised
patients considered at risk
as a consequence of HIV
infections or neutropenia
following cytotoxic
chemotherapy, radiotherapy
or bone marrow transplant

i) Oropharyngeal candidiasis: 50-100


mg dly for 7-14 days (Max 14 days)
except in severely
immunocompromised patients,
treatment can be continued for longer
periods.
Atrophic oral candidiasis associated
with dentures: 50 mg dly for 14 days.
Other candidal infections of mucosa:
50-100 mg dly for 14-30 days.
CHILD: 3-6 mg/kg on first day then 3
mg/kg dly (every 72 hrs in NEONATE
up to 2 wks old, every 48 hrs in
NEONATE 2-4 wks old)
ii) 50 mg daily for 2-4 wks, max 6 wks
iii) 400 mg initially then 200-400 mg
dly for 6 - 8 wks.
CHILD: 6-12 mg/kg daily (every 72 hrs
in NEONATE up to 2 wks old, every
48 hrs in NEONATE 2-4 wks old)
iv) 100 -200 mg dly
v) 50-400 mg daily. CHILD: 3-12
mg/kg dly (every 72 hours in
NEONATE up to 2 wks old, every 48
hrs in NEONATE 2-4 wks old)

RM1.29/cap

i) Dermatomycosis including
pityriasis versicolor
ii) Oral candidiasis
iii) Palmar tinea manus and
plantar tinea pedis
iv) Fingernail
onychomycosis
v) Toenail onychomycosis
vi) Vulvovaginal candidiasis

i) 200 mg od for 7 days


ii) 100 mg dly for 15 days
iii) 200 mg bd for 7 days
iv) 200 mg bd for 1 wk/mth
v) 200 mg bd for 1 wk/mth for 3 mths
vi) 200 mg morning and evening for 1
day or 200 mg od for 3 days

RM0.74/cap

A/KK i) Pityriasis versicolor


ii) Systemic mycosis (other
skin mycoses)
iii) Nail infections

40

RM19.80/vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
7 Caspofungin Acetate
50mg Injection
(Cancidas)

J04 Antimycobacterials
No Generic Name
1 Rifampicin 150 mg
Capsule

Cat Indications
A* i) Confirmed systemic fungal
infection in patients who are
refractory or intolerant to
other fungal therapies. ii)
For pediatric patient (12 mth
and older) for the following
indications:
a) Empirical therapy for
presumed fungal infections
in febrile, neutropenic
patients
b) Treatment of invasive
candidiasis, including
candidemia and the
following Candida infections
; intra-abdominal
abscesses, peritonitis and
pleural space infections
c) Treatment of esophageal
candidiasis d) Treatment of
invasive Aspergillosis in
patients who are refractory
to or intolerant of others
therapy (eg: Amphotericin
B)

Dosage
Remark
RM573.40/
i) Invasive aspergillosis & invasive
vial
candidiasis: ADULT: Initially, 70 mg
infused over 1 hr followed by
Borang E
subsequent doses of 50 mg/day.
Oesophageal candidiasis: ADULT: 50
mg by slow IV infusion over
approximately 1 hr
ii) For all indications, a loading dose of
70mg/m2 on D1 followed by
maintenance dose of 50mg/m2 od.

Cat Indications
B i) Tuberculosis
ii) Leprosy
iii) Prophylaxis for
meningococcal meningitis
B

Dosage
Remark
RM0.17/cap
i) ADULT: 450 - 600 mg as a single
morning dose. CHILD: 10 - 20 mg/kg
dly in 1-2 doses. Directly observed
therapy (DOT): 10 mg/kg twice wkly or
RM0.29/cap
3 times/wk. Max: 600 mg
ii) 600 mg/day
iii) 600 mg bd for 2 days

Rifampicin 300 mg
Capsule

Isoniazid 100 mg Tablet

i) Tuberculosis
ii)Tuberculous meningitis

i) ADULT and CHILD 5 mg/kg (4-6


mg/kg) daily,max 300 mg daily) or 10
mg/kg 3 times wkly
ii) 15 - 20 mg/kg dly

RM0.02/cap

Pyrazinamide 500 mg
Tablet

Tuberculosis

ADULT & CHILD : 25 mg/kg dly or 35


mg/kg 3 times wkly

RM0.16/tab

Ethambutol HCl 400 mg


Tablet

Tuberculosis

ADULT & CHILD > 13 yrs: Initial


treatment: 15 mg/kg as a single dly
dose 24 hrly. Retreatment: 25
mg/kg/day as a single dose 24 hrly.
Concurrent anti-TB drug required.
After 60 days, decrease to 15 mg/kg
as single dose 24 hrly

RM0.28/tab

Dapsone 100 mg Tablet

i) Leprosy
ii) Dermatitis herpetiformis

i) ADULT: 6 - 10 mg/kg wkly (around


50 - 100 mg dly). CHILD: 1 - 2
mg/kg/day. Max: 100 mg/day
ii) ADULT: 50 - 300 mg dly

RM0.06/tab

41

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

J05 Antivirals for Systemic Use


No Generic Name
Cat Indications
1 Acyclovir 250 mg
A* Treatment and prophylaxis of
herpes simplex in
Injection
immunocompromised, severe
initial genital herpes and
Varicella -Zoster

Acyclovir 200 mg Tablet

Acyclovir 800 mg Tablet

Ganciclovir Sodium 500


mg/10 ml Injection

A/KK i) Mucocutaneous Herpes


Simplex infection in
immunocompromised and
AIDS patients ii) Primary
and recurrent Varicella
Zoster infection in
immunocompromised and
AIDS patients iii) Severe
Kaposi Varicella Eruption
(Eczema herpeticum) iv)
Severe primary HSV
infections (eg. Neonatal
herpes, encephalitis,
eczema herpeticum, genital
A herpes, gingival stomatitis,
vaginal delivery with
maternal vulva herpes) v)
Severe and complicated
varicella infection (eg.
Encephalitis, purpura
fulminans) vi) Severe zoster
infection in paediatrics (eg.
Encephalitis, purpura
fulminans,
immunocompromised
patients and facial, sacral
and motor zoster)
A*

Treatment of
cytomegalovirus (CMV)
disease in
immunocompromised
patients, prevention of CMV
disease during
immunosuppressive therapy
following organ
transplantation

42

Dosage
Remark
ADULT: 5 mg/kg by IV infusion tds for RM5.80/vial
5 days, doubled to 10mg/kg tds in
varicella-zoster in the
immunocompromised and in simplex
encephalitis (usually given for at least
10 days in encephalitis; possibly for 14
- 21 days). Neonate & Infant up to 3
mths with disseminated herpes
simplex: 20mg/kg tds for 14 days (21
days in CNS involvement), varicellazoster 10-20mg/kg tds usually for 7
days. CHILD, 3 mths -12 yrs: Herpes
simplex or Varicella Zoster: 250
mg/m2 tds for 5 days, doubled to 500
mg/m2 tds for varicella-zoster in the
immunocompromised and in simplex
encephalitis (usually given for 10 days
in encephalitis)
i) ADULT: initially 400 mg 5 times dly
for 7-14 days.
CHILD < 2 yrs: 200 mg 4 times dly,
CHILD > 2 yrs: 400 mg 4 times dly
ii), iii) and iv) ADULT: 200 - 400 mg 4
times dly.
CHILD: < 2 yrs, half adult dose;
> 2 yrs, adult dose
v) ADULT: 800 mg 5 times dly for 7
days
vi) ADULT: 20 mg/kg (max: 800 mg) 4
times dly for 5 days,
CHILD 6 yrs: 800 mg 4 times dly.
CHILD l< 2 yrs; 400mg 4 times dly,
> 2 yrs; 800mg 4 times dly

RM0.55/tab

RM0.57/tab

Initial: 5 mg/kg infused over 1 hr bd for RM146/unit


14-21 days (CMV retinitis treatment) or
7-14 days (CMV disease prevention). Borang E
Long term maintenance: 6 mg/kg dly
for 5 days/wk or 5 mg/kg dly for 7
days/wk

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Indinavir Sulphate 400
mg Capsule

Cat Indications
Dosage
Remark
RM1.90/cap
A* i) Post-exposure prophylaxis ADULT: 800 mg tds.
(PEP) among healthcare
CHILD (investigational): 500 mg/m2
workers in high-risk HIV
tds (patients with smaller body surface
occupational exposure
area (BSA) may require lower doses
ii) For therapy as part of
of 300 - 400 mg/m2 tds)
combination antiretroviral
treatment on adult HIV
patients ie Highly Active AntiRetroviral Therapy (HAART)

Ritonavir 100 mg
Capsule

A*

Progressive or advanced
HIV infection in combination
with other antiretroviral
agents. Criteria for use: a)
Clinical AIDS b) CD4 < 350
cells or c) Viral load >
10,000 copies/ml

ADULT: initially 300 mg bd, increase


by 100 mg bd increments to 600 mg
bd. For older child who can swallow
soft gelatin capsule; 250 mg/m2 bd for
2 days, if tolerate 400 mg/m2 bd
onwards

RM3.18/cap

Lopinavir/Ritonavir Oral
Solution

Management of patients
with asymptomatic and
symptomatic (early or
advanced) HIV Infection
with CD4 cell counts

12 mg/kg bd for those 7 - 15 kg and


10mg/kg twice daily for those 15 - 40
kg taken with food, up to a maximum
dose of 533 mg Lopinavir/13.3mg
Ritonavir in children > 45 kg (5 ml) bd.
Dose may varies depending on types
of combination used

RM795.50/
160ml

A*

As second line protease


ADULT and CHILD with BSA > 1.4 m2 RM7.79/tab
inhibitor if intolerant to
or > 40kg: 2 tablets bd
Borang E
indinavir/ ritonavir as part of
HAART regimen

(Kaletra)

Lopinavir 200 mg and


Ritonavir 50 mg capsule
(Kaletra)

Zidovudine 100 mg
Capsule

10

Zidovudine 10 mg/ml
Syrup

11

Zidovudine 1% Injection

12

Stavudine 30 mg Tablet

A/KK i) Management of patients


with asymptomatic and
symptomatic (early or
advanced) HIV infections
A* with CD4 cell counts less
than 500 cu. mm
ii) Neonatal prophylaxis
A

To reduce the rate of


maternal-foetal transmission
of HIV in: i) HIV-positive
pregnant women over 14
weeks of gestation ii) Their
newborn infants

A/KK HIV infection, in


combination with other
antiretrovirals

43

i) Adult: 500-600 mg/day in 2-3 divided


doses.
Child > 3 mths: 360-480 mg/m2 dly in
3-4 divided doses; max 200 mg qid
ii) 2 mg/kg qid within 12 hrs after birth
up to 6 wks

RM1.02/cap

i) 200 mg tds or 300 mg bd until start


of labor. During labour, by IV infusion
initially 2 mg/kg over 1 hr followed by
continuous IV infusion at 1 mg/kg/hr
until delivery ii) 2 mg/kg orally qid
within 12 hrs after birth. If unable to
receive oral dose: FULL TERM: 1.5
mg/kg/dose qid, INFANTS 30 wks and
< 35 wks gestation at birth: 1.5
mg/kg/dose bd; at 2 wks of age,
advance to 1.5 mg/kg/dose tds,
INFANTS < 30 wks gestation at birth:
1.5 mg/kg/dose bd; at 4 wks of age,
advance to 1.5 mg/kg/dose tds

RM735.60/
vial

ADULT > 60 kg: 40 mg bd; < 60 kg: 30


mg bd. CHILD < 30 kg: 30 mg bd; < 30
kg: 15 mg bd

RM0.67/tab

RM50.80/ vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
13 Lamivudine 10 mg/ml
Oral Solution
(3TC)

Cat Indications
A* HIV infection in combination
with other antiretroviral
agents

14

A*

Lamivudine 100 mg
Tablet
(Zeffix)

15

Lamivudine 150 mg
Tablet
(3TC)

16

Adefovir Dipivoxil 10 mg
Tablet
(Hepsera)

17

Nevirapine 200 mg Tablet

18

Efavirenz 200 mg
Capsule
(Stocrin)

19

Efavirenz 600 mg Tablet


(Stocrin)

Dosage
Remark
RM231.40/
ADULT: 150 mg bd or 300 mg od.
INFANT < 1 mth: 2 mg/kg bd. CHILD 1 240ml
month or over: 4 mg/kg bd. Max: 300
mg dly
RM7.33/tab
Management of chronic
ADOLESCENTS > 16 yrs and
hepatitis B infection
ADULTS: 100 mg/dose od
Borang E
associated with evidence of
hepatitis B viral replication
and active liver inflammation

A/KK HIV infection in combination ADULT: 150 mg bd or 300 mg od.


with other antiretroviral
INFANT < 1 mth: 2 mg/kg bd. CHILD 1
agents
month or over: 4 mg/kg bd. Max: 300
mg dly
A* i) Treatment of chronic
Adult over 18 years: 10mg once daily
HBeAg positive and HBeAg
negative hepatitis B
infection in adults with
compensated liver function
(lamivudine should be tried
first)
ii) Lamivudine-resistant
chronic hepatitis B virus
infection with either
compensated or
decompensated hepatitis
function
A*

Treatment of HIV-1 infection 200 mg od for first 14 days then 200


in combination with other
mg bd
antiretroviral agents

RM2.60/tab

RM8.42/tab
(Only by
hepatologist
and
gastroenterolo
gist for
approved
indications)

RM0.67/tab

RM2.86/cap
ADULT: 600 mg od.
CHILD < 17 yrs, > 40 kg: 600 mg od,
32.5 - 40 kg: 400 mg od, 25 - 32.5 kg:
350 mg od, 20 - 25 kg: 300 mg od, 15 20 kg: 250 mg od, 13 - 15 kg: 200 mg RM6.51/tab
od. No studies in children < 3 yrs or <
13 kg. Tablet formulation unsuitable
for children < 40 kg
RM3.03/tab
A/KK HIV infection in combination ADULT and CHILD > 12 years: 1
with at least one other
tablet bd
antiretroviral drug

A*

Combination therapy for HIV


infections with a protease
inhibitor and or Nucleoside
Reverse Transcriptase
A/KK Inhibitors (NRTIs)

20

Zidovudine 300 mg
Tablet & Lamivudine 150
mg Tablet (Combivir)

21

Tenofovir Disoproxil
Fumarate 300 mg &
Emricitabine 200 mg
Tablet
(Tenvir EM)

22

Stavudine 30mg &


A/KK Fixed dose triple therapy for 1 tablet bd for patients < 60 kg
Lamivudine 150mg &
treatment of HIV infection in
Nevirapine 200mg Tablet
adults once patients have
(SLN 30)
been stabilized on the
maintenance regimen of
nevirapine 200 mg bd and
have demonstrated
adequate tolerability to
nevirapine

A*

Treatment of HIV-1 infection 1 tablet once daily.


in adults in combination with
other antiretroviral agents
(such as non-nucleoside
reverse transcriptase
inhibitors or protease
inhibitors).

44

RM5.33/tab

RM2.82/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

J06 Immune Sera and Immunoglobulins


No Generic Name
Cat Indications
1 Antivenene Malaysian Pit
B Bitten by pit viper
Viper Injection

Dosage
Remark
Reconstitute content for the vial with 5 RM344.77/
ml sterile pyrogen-free distilled water. vial
Administer by IV infusion 200 ml of
normal saline over a period of 1 - 2 hrs

Antivenene Serum
(Cobra) Injection

Treatment for cobra bites

Antivenene Serum (Sea


snake) 1000 units/26.3ml
Injection

Treatment for sea snake


bites

Antivene Serum Snake


polyvalent Injection

Antidote for snake bites

Recommended initial dose is 20ml by RM148.20/


vial
intravenous infusion. The injection
should be given very slowly as 5 mins
KPK
by direct slow IV route or 1hr by
infusion. If symptoms continue, further
doses are administered as required
until symptoms completely disappear

Anti RhD Gamma


Globulin 250 mcg/2 ml
Injection (500 units=100
mcg)
(Rhogram)

Prevention of Rh(D)
sensitisation by IM injection
to rhesus-negative woman
after delivery of rhesuspositive infant

50 - 100 mcg within 72 hours after


incompatible blood transfusion: 25
mcg (125 units) per ml transfused
blood, up to 1000 mcg

RM331.76/
vial

Tetanus Immunoglobulin,
Human 250 Units/Vial
Injection

Passive immunization
against tetanus

Prophylaxis of tetanus: IM 250 units.


Treatment of tetanus: IM 30 - 300
units/kg

RM63.91/ea

Hepatitis B
Immunoglobulin (Human)
Injection

i) For post-exposure
prophylaxis of hepatitis B
ii) Prophylaxis against
recurrence of hepatitis B
infection in chronic hepatitis
B post liver transplantation

i) ADULT and CHILD > 10 yrs: A


single dose of 500 units IM within 48
hrs and not > 1 wk after exposure
ii) Different regimens depending on
hepatitis B virus (HBV) DNA positivity

RM128.50/ea

(Hepa-big)

45

The reconstituted antivenin should be


given by slow IV infusion,
approximately 2ml/min.Subsequent
dose can be given bd according to the
clinical symptoms
1000 units by IV infusion over 1/2 to 1
hr. In severe cases 3000 -10000 units
may be required

RM344.77/
vial

RM13224.0/
vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

J07 Vaccines
No Generic Name
1 Haemophilus Influenzae
Type B Conjugate 10
mcg Vaccine

Cat Indications
C Immunisation of infants
against Haemophilus
Influenzae Type B

Dosage
0.5 ml IM

Remark
RM31.66/vial

Meningococcal A, C, Y,
W135 Vaccine Injection

Immunisation against
Prophylaxis: 0.5 ml SC
meningococcal diseases
caused by Neisseria
meningitis Group A, Group
C, Group Y or Group W-135

RM55.00/vial
(1 dose),
RM290.00/
vial (10 dose)

Pneumococcal Vaccine
(Polyvalent)

Prevention of pneumococcal
infections in high risk
subjects from the age of 2
years including patient with
a history of splenectomy or
scheduled splenectomy

Primary injection: 1 single injection


(0.5 ml) only. Booster: Must not be
given within 5 yrs except in very high
risk patient who received the vaccine
while under immunosuppressive
treatment

RM49.30/vial

Tetanus Toxoid Injection

Immunization against
tetanus infection

0.5 ml at 2 mths followed by second


dose after 4 wks and third dose after
another 4 wks. Booster every 10 yrs

RM5.84/vial

BCG.Freeze-dried
Vaccine Injection

For the prevention of


tuberculosis

0.1 ml by intradermal injection.


INFANT < 12 mths: 0.05 ml

RM13.07/vial

Typhoid Vaccine Injection

Active immunization against 0.5 ml single IM injection into the


typhoid fever in adult and
deltoid or vastus lateralis, may
child more than 2 years
reimmunize with 0.5 ml IM every 2 yrs
if needed

RM13.92/vial

Hepatitis B Vaccine
Injection

Immunisation against
infections caused by
Hepatitis B virus

ADULTS > 20 yrs: 10 mcg/dose.


ADOLESCENT 11 - 19 years: 5
mcg/dose.
NEWBORN and CHILD up to 10
years: 2.5 mcg/dose.
INFANTS born to HBsAg positive
mothers: 3 doses of 0.5 ml each.
Second dose to be given after 1 mth
and booster dose after 6 mths

RM4.87/vial
(Adult - 1
dose),
RM2.43/vial
(Paed 10mcg/0.5ml)

Rabies Human Diploid


Cell Vaccine
(Lyophilised) Injection

Pre-exposure and postexposure vaccination


against rabies

Prophylaxis: 3 dose (1 ml each)


schedule on days 0, 7 and 28. Booster
dose after every 2 - 3 yrs.
Post exposure prophylaxis: use after
attack of a potential rabid animal: 1
dose on days 0, 3, 7, 14 and 30. In
previously vaccinated individuals 2
doses on day 0 and 3

RM310.35/
vial

46

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

L01 Antineoplastic Agents


No Generic Name
1 Cyclophosphamide 1g
Injection

Cyclophosphamide
mg Tablet

50

Cat Indications
A i) Solid tumours (adult and
paediatric), leukaemia, nonHodgkin's lymphoma,
multiple myeloma
ii) Severe lupus nephritis
(Class III and IV)
iii) Other systemic vasculitis
iv) Systemic lupus
erythematosus, rheumatoid
arthritis, polyarteritis
nodosa, wegener
granulomatosis
v) Pemphigus vulgaris

Dosage
Remark
RM19.73/vial
i) ADULT: 600 - 750 mg/m2 IV once
every 3 wks as part of combination
Care with pre
regime. CHILD: Dose variable
and postdepending on disease and protocol.
hydration.
Range 600 mg/m2 to 2 g/m2 infusion Mesna to be
given with
over 1 - 6 hrs (lower doses can be
doses > 1
given as bolus). Higher doses are
g/m2.
used in haematopoetic stem cell
transplant-refer to specific protocols
ii) 750 mg/m2 BSA mthly for 18 mths
iii) 750 mg/m2 BSA mthly for 6 mths.
Dose can be adjusted up to 1,000
mg/m2 BSA to achieve adequate
leucocyte suppression
iv) 500 - 1000 mg IV (Regime varies
according to indication). Starting dose
may be given fortnightly then at mthly
intervals followed by 3 mthly intervals
v) 500 mg infusion on the 2nd day of
the dexamethasonecyclophosphamide pulsed regime, the
cycle is repeated every 4 wks up to 6
cycles or till remission followed by oral
cyclophosphamide

i) Solid tumours, leukaemia,


lymphoma, autoimmune
disorders, autoimmune
bullous diseases,
connective tissue disease,
pyoderma gangrenosum
ii) For severe lupus nephritis
(Class III & IV), systemic
vasculitis and steroid
resistant/dependent
nephrotic syndrome
iii) Systemic lupus
erythematosus (SLE),
rheumatoid arthritis,
polyarteritis nodosa,
wegener granulomatosis

i) ADULT: 50 - 100 mg/day. Monitor


full blood count (FBC), liver function,
urine microscopy and renal function.
CHILD, up to 1 yr: 10-20 mg dly,
1-5 yrs: 30-50 mg dly,
6-12 yrs: 50-100 mg dly
ii) 2 mg/kg/day for 3-4 mths
iii) 1 - 1.5 mg/kg/day orally in divided
doses

RM7.68/tab

RM2.62/tab

Borang E

Chlorambucil 2mg Tablet

Low grade lymphoma,


chronic lymphocytic
leukaemia. Ovarian cancer

200 mcg/kg dly for 4 - 8 wks

Ifosfamide 1 g Injection

A*

i) Solid tumours
ii) Leukaemia
iii) Lymphoma

i) 1.2 - 2.4 g/m2/day for 3 - 7 days as a RM69.60/vial


30-120 mins infusion. Alternatively,
can also be given as a single high
dose, eg. 5 g/m2 in a 24 hr infusion.
Cycles may be repeated every 3-4 wks
ii) CHILD: 400 - 3000 mg/m2/day for 3 5 days according to protocol
iii) Refer to protocols

47

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Dacarbazine 100 mg
Injection

Cat Indications
A* i) Malignant melanoma,
sarcomas, neuroblastomas
and other childhood solid
tumours
ii) Hodgkin's Disease

Dosage
i) 250 mg/m2 for 5 days, may be
repeated every 3 wks
ii) 375 mg/m2 IV every 2 wks

Remark
RM36.30/ea

Methotrexate 50 mg
Injection

i) Solid tumours
ii) Gestational trophoblastic
disease
iii) Acute
leukaemia/lymphomas
iv) Rheumatoid arthritis,
psoriatic arthropathy,
severe/erythrodermic
psoriasis

i) 50 mg/m2 once every 2 - 3 wks in


combination with other drugs
ii) 50 mg IV Day 1, 3, 5, 9 every 3 wks.
For high risk gestational trophoblastic
disease, use 100 mg/m2 as part of
EMA-CO regime
iii) High dose regimes: 500 - 3000
mg/m2 per dose may be used,
employing the 500 mg preparations.
CHILD: CNS prophylaxis for acute
leukaemia 2 gm/m2 over 24 hrs with
folinic acid rescue, 3 doses for B-cell
lineage. 4 doses for T-lineage all every
3 wks. Relapse ALL: 1 gm/m2 over 36
hrs with folinic acid rescue every 3
wks for 9 doses, maintenance: 50
mg/m2 every 2 wks. B-cell lymphoma:
3 gm/m2 over 3 hrs with folinic acid
rescue for three doses. Dosage for
intrathecal treatment and prophylaxis
in leukaemia: less than 1 year: 5 mg, 1
- 2 years: 7.5 mg, 2 - 3 years: 10 mg,
more than 3 years: 12.5 mg.
iv) Dose used by rheumatologist: 10 15 mg IM injection or oral wkly. Dose
used by dermatologist: 10 - 25 mg IM
injection wkly

RM8.70/vial

Methotrexate Sod 2.5 mg


Tablet

i) Acute lymphoblastic
leukaemia and acute
promyelocytic leukemia
(maintenance)
ii) Extensive plaque
psoriasis, erythrodermic
psoriasis, pustular psoriasis,
Reiter's syndrome,
connective tissue disease

i) ADULT: 20 mg/m2 wkly. CHILD: 2030 mg/m2 wkly according to protocol


ii) Relapsed acute lymphoblastic
leukaemia (ALL): 100 mg/m2/day for 5
days 6 wkly according to protocol
iii) Dose used by dermatologist: 5-25
mg wkly. Liver biopsy after cumulative
dose of 1.5 g and repeat liver biopsy
with additional gram received. Max
cumulative dose is 4g. Monitor full
blood count (FBC), renal and liver
function
iv) Rheumatoid arthritis, psoriatic
arthropathy: dose used by
rheumatologist: 2.5 mg/wk orally
starting dose, increasing to 7.5 - 20
mg/wkly

RM0.32/tab

Fluorouracil 1 g/20 ml
Injection

A*

Cancers of gastro-intestinal
tract, breast and pancreas,
head and neck.
Ophtalmological indication:
trabeculectomy

500-600 mg/m2 IV in combination with


other cytotoxic agents, repeated every
3 wks or 300-450 mg/m2 IV slow bolus
dly for 5 days in combination with
biological response modifiers,
repeated every 4 wks or 3000-3750
mg/m2 as a continuous infusion over 5
days in combination with a platinum
compound every 3 to 4 wks

RM98.80/ vial

(5-FU)

48

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
9 Cytarabine (Cytosine
Arabinoside) 100 mg
Injection

Cat Indications
A i) Central nervous system
lymphoma
ii) Meningeal leukemia
iii) Non Hodgkin's
Lymphoma
iv) High dose cytarabine as
conditioning to cytoreduce
the disease before stem cell
transplant for relapsed or
refractory leukemia
v) As salvage for acute
lymphocytic leukemia
vi) As salvage for acute
myeloid leukemia
vii) As palliative
chemotherapy in elderly
acute myeloid leukemia/
myelodysplastic syndrome

Dosage
Remark
RM1.50/ea
Standard doses 100-200 mg/m2 dly
over 5-10 days. Higher doses for
intensification/consolidation: 1000 3000 mg/m2 dly over 3-5 days
depending on specific protocols.
CHILD: Dose variable depending on
disease and protocol. Range from 100
mg/m2 to 3 g/m2 bd. May be given as
SC, IV bolus or infusion.
Intrathecal dose: < 1 yr: 15 mg, 1-2
yrs: 20 mg, 2-3 yrs: 25 mg, > 3 yrs: 30
mg. (ENSURE THAT PREPARATION
IS SUITABLE FOR INTRATHECAL
USE)

10

A*

i) Locally advanced or
metastatic non-small cell
lung cancer
ii) Locally advanced or
metastatic pancreatic
cancer
iii) In combination with
carboplatin in the treatment
of patients with recurrent
epithelial ovarian
carcinoma, who have
relapsed more than six
months,
following
i) Metastatic
breastplatinumcancer

i) Alone or with cisplatin: 1000 mg/m2


day 1 & 8 every 3 wks or 1000 mg/m2
day 1, day 8, day 15 every 4 wks
ii) Initially 1000 mg/m2 wkly for 7 wks
followed by 1 wk rest. Subsequent
cycles 1000 mg/ m2 wkly for 3 wks
followed by 1 wk rest
iii) Gemcitabine 1000 mg/m2 as 30
minutes IV infusion day 1 & 8 of each
21-day cycle followed by carboplatin
on day 1 to attain a target AUC of 4
mg/ml/min
iv)
mg/m2
on days
1 and 8and
of
i) &1250
ii) 1250
mg/m2
bd (morning

in elderly and poor


performance status patients
and refractory to taxanes.
ii) Metastatic colon cancer,
first line in elderly and poor
performance status patients
iii) Colon cancer, adjuvant
therapy for stage III (Duke's
Satage C) following surgery
iv) First line treatment of
patients with advanced
gastric cancer in
combination with a platinumbased regimen

evening) for 2 wks, every 21 days


iii) Recommended for a total of 24 wks Borang E
(8 cycles of 2 wks of drug
administration and 1 wk rest period)
iv) In combination with a platinum on
day 1, give capecitabine 1250 mg/m2
bd for 14 days. Repeated every 3 wks
for 8 cycles or optimum number of
cycles

Gemcitabine HCl 1g
Injection
(Gemzar)

11

Capecitabine 500 mg
Tablet

A*

(Xeloda)

RM151.50/
vial

RM10.33/tab

12

Vinblastine Sulphate 10
mg Injection

Hodgkin's disease,
choriocarcinoma resistant to
other chemotherapeutic
agents, non-small cell lung
cancer, Langerhans cell
histiocytosis

ADULT: Lung cancer - 6 mg/m2 (max:


10 mg) on Day 1. Hodgkin's diseaserefer to protocol.
CHILD: Usual wkly dose: 6 mg/m2
wkly or 3 wkly depending on protocol

RM90.65/vial

13

Vincristine Sulphate 1mg


Inj

i) Solid tumours
ii) Gestational trophoblastic
disease
iii) Non-Hodgkin's
lymphoma
iv) Multiple myeloma
v) Acute lymphoblastic
leukemia

i) ADULT: 1.4 mg/m2 wkly (max: 2 mg


wkly)
ii) Refer to protocol
iii) 1.4 mg/m2 wkly (max: 2 mg wkly)
iv) 0.4 mg/m2 IV continuous infusion
on days 1-4
v) Refer to protocol. CHILD: 1-2
mg/m2 wkly according to protocol
(0.05 mg/kg for infants < 10kg)

RM25.52/vial
(1mg/1ml),
RM8.60/vial
(2mg/2ml)

49

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
14 Vinorelbine 10mg Inj

Cat Indications
A* i) First line treatment in nonsmall cell lung cancer in
combination with
A* cisplatin/ifosfomide
ii) Metastatic breast cancer

Dosage
Strictly IV 25 - 30 mg/m2 diluted in
saline solution, infused over 6-10
mins, administered wkly or day 1, 8
every 3 wks

Remark
RM66/vial

RM325.9/vial

15

Vinorelbine 50mg Inj

16

Etoposide 100 mg/5 mg


Injection

A*

i) For treatment of children


with solid tumours, juvenile
myelomonocytic leukemia
(JMML) and Langerhan cell
histiocytosis
ii) Leukaemia, lymphoma
iii) Testicular cancer, lung
cancer, gestational
trophoblastic disease,
gastric cancer, sarcoma

i) CHILD: 60-120 mg/m2/day by IV for


3-5 days every 3-6 wks depending on
protocols
ii) Maintenance or palliative
chemotherapy for elderly acute
myeloid leukemia, consolidation
therapy for acute lymphoblastic
leukemia, stem cell mobilization (Refer
to protocol)
iii) 100 mg/m2 by IV every other day
for 3 doses repeated every 3-4 wks

RM17/vial

17

Paclitaxel 300 mg
Injection

A*

i) Treatment of recurrent
breast cancer, after failure
of anthracycline-based
chemotherapy
ii) Primary adjuvant therapy
in advanced ovarian cancer
in combination with cisplatin
iii) Treatment of locally
advanced or metastatic nonsmall cell lung cancer
(NSCLC) in chemonaive
patients in combination with
platinum compounds

i) 175 mg/m2 IV over 3 hours every 3


weeks ii) 175 mg/m2 IV over 3 hour
followed by cisplatin 75 mg/m2 in
every 3 weeks or 135 mg/m2 IV over
24 hours followed by cisplatin 75
mg/m2 every 3 weeks iii) 135 mg/m2
IV over 24 hours followed by cisplatin
75 mg/m2 every 3 weeks

RM235/vial

18

Docetaxel 20mg/0.5ml
Injection

A*

Docetaxel 80mg/2ml
Injection

A*

i) 75 mg/m2 IV over 1 hr after


doxorubicin 50 mg/m2 and
cyclophosphamide 500 mg/m2 every 3
wk for 6 cycles
ii) 75 mg/m2 IV over 1 hr every 3 wk in
combination with doxorubicin 50
mg/m2
iii) Administer IV over 1 hr IV every 3
wks. Chemotherapy-naive patients 75
mg/m2 immediately followed by 75
mg/m2 cisplatin over 30-60 mins or
carboplatin (AUC 6 mg/mL/min) over
30-60 minutes. Monotherapy of non
small cell lung cancer (NSCLC) after
failure of prior platinum-based
chemotherapy 75 mg/m2
iv) 100 mg/m2 over 1 hr every 3 wks
v) 60-75 mg/m2 IV over 1 hr every 3
wks, administer with oral prednisone 5
mg bd given continuosly

RM684.66/
vial

19

i) Adjuvant treatment of
patients with high risk nodepositive breast cancer in
combination with
doxorubicin and
cyclophosphamide,
ii) Breast cancer, locally
advanced or metastatic, not
previously on cytotoxic
therapy, in combination with
doxorubicin,
iii) First line therapy in non
small cell lung cancer in
stage 3-4 and performance
status 0-1, in combination
with cisplatin,
iv) Inoperable locally
advanced squamous cell
carcinoma of head and
neck, in combination with
cisplatin and 5-FU for
induction treatment,
v) Prostate cancer, in
combination with
prednisolone

20

Actinomycin D
(Dactinomycin) 500
mcg/3ml Injection

i) For solid tumours


i) ADULT: 500 mcg IV dly for max of 5
ii) Gestational trophoblastic days. CHILD: 1.5 mg/m2 once every 3
disease
wks (if < 10 kg, 50 mcg/kg)
ii) 500 mcg IV on Days 2, 4, 6, 8, 10,
repeat every 7-10 days or 500 mcg IV
bolus on Days 1 and 2, repeat every
15 days
50

RM1215.97/
vial

RM45.00/vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
21 Doxorubicin HCl 50 mg
Injection

Cat Indications
A i) Solid tumours, leukaemia,
non-Hodgkin's lymphoma
ii) Leukaemia (ALL
induction)
iii) Multiple myeloma

Dosage
Remark
i) 30 - 75 mg/m2 IV as a single dose at RM29.45/vial
21 day intervals
ii) 25 - 45 mg/m2 once a wk for the
first 4 wks during induction or reinduction phase (refer to specific
protocol. Caution: Total cumulative
dose of doxorubicin must not exceed
550 mg/m2 due to risk of
cardiotoxicity. CHILD: 30 mg/m2/dose RM11.60/vial
over 6-24 hrs for 1-2 days. Need to
check cardiac function closely by
echocardiography every cumulative
dose of 100 mg/m2 to max: 360
mg/m2
iii) 9 mg/m2 over 24 hrs infusion for 4
days at mthly intervals

22

Doxorubicin HCl 10 mg
Injection

23

Epirubicin 50 mg Injection

A*

Breast cancer, NonHodgkin's lymphoma,


Leukaemia (ALL induction),
gastric cancer, ovarian
cancer

60-100 mg/m2 injected IV in 3-5 min,


repeated at 21 day intervals.
CHILD: 50 mg/m2 over 6 hrs.
Schedule depends on protocol

RM114.84/
vial

24

Bleomycin HCl 15 mg
Injection

Squamous cell carcinoma,


germ cell tumours,
lymphomas. Routes: SC,
IM, IV (either as bolus or as
infusion over 24 hrs), intraarterial, intra-pleural

15 - 60 mg wkly in divided doses or 10


- 20 mg/m2 once or twice wkly or 10
mg/m2 slow bolus in 15 mins D1 and
D15. Max: 400 mg. CHILD: 10-15
mg/m2 over 6 hrs every 3-4 wks

RM158.92/
vial

25

Mitomycin-C 10 mg
Injection

A*

i) Gastrointestinal, lung,
breast, cervical cancers
ii) Bladder tumours
iii) Opthalmological
conditions: conjunctival
squamous neoplasia,
squamous cell carcinoma of
conjunctiva, trabeculectomy
chronic lymphocytic
leukaemia, chronic
myelogenous leukaemia.
Gastric, colorectal, lung
cancer

i) 10 - 20 mg/m2 given as a single


dose through a running IV infusion
repeated every 6-8 wks. The whole
schedule may be repeated depending
on the bone marrow
ii) 10-40 mg dly or every other day
(intravesical)
iii) 0.4 mg topically as a single
application for opthalmological
conditions, duration: 1 to 3 mins

RM208.80/
vial

26

Cisplatin (Cis-Platinum)
50 mg Injection

Germ cell tumours, ovarian


tumours, adult solid
tumours, lymphomas

Germ cell tumours: 20 mg/m2 dly for 5


days every 3 wks for 3-4 courses.
Ovarian tumours: 75 mg/m2 once
every 3 wks as part of combination
therapy or 100 mg/m2 IV once every 3
wks as a single agent. Baseline
creatinine clearance, pretreatment
hydration and forced diuresis are
mandatory. CHILD: 100mg/m2 over 6
hrs once every 3 wks. Lymphomas:
Refer to protocols

RM18.56/vial

27

Carboplatin 450 mg
Injection

A*

Adult solid tumours,


360 - 400 mg/m2, by IV infusion over
paediatric tumours. Salvage 15 mins to 1 hr on Day 1 every 4 wks.
therapy for lymphoma
Alternatively, prescription may be
based on Area Under Curve (AUC)
calculations. CHILD: 500-600 mg/m2
over 1 hr once every 3 wks. Salvage
regimes in lymphomas - refer to
specific protocols

51

RM86.70/ vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
28 Oxaliplatin 100mg/50ml
Injection

Cat Indications
Dosage
A* Only for patients with
85 mg/m2 IV repeated every 2 wks
colorectal cancer who: i)
have relapsed within 6
months after the end of
adjuvant chemotherapy with
5-fluorouracil-based regime
ii) have progressive disease
despite 5-fluorouracil
chemotherapy for advanced
disease iii) good
performance status (WHO
of 2 or less). The treatment
must be given in a tertiary
oncology centre or have
clearance in writing by an
oncologist

29

L-Asparaginase 10,000
IU Injection

A*

i) Acute lymphoblastic
i) 5,000 iu/m2 for 10 days during
leukemia
induction, 10,000 iu/m2 also used with
ii) Non-hodgkin's lymphoma high dose methotrexate rescue in
consolidation phase of acute
lymphoblastic leukemia
ii) CHILD: 5,000 - 25,000 iu/m2 per
dose depending on protocol

30

Gefitinib 250 mg tablet

A*

For the treatment of patients 250mg tablet once a day, taken with or RM214.50/tab
with locally advanced or
without food
Borang E
metastatic non-small cell
lung cancer (NSCLC) who
have previously failed
chemotherapy, and who
have activating mutation of
epidermal growth factor
receptor (EGFR). Restricted
to non-smoker, female,
EGFR positive and Asian
patients only.

A*

i) As monotherapy for
maintenance treatment in
patients with locally
advanced or metastatic nonsmall cell lung cancer
(NSCLC) with stable
disease after 4 cycles of
standard platinum-based
first-line chemotherapy.
ii) For the treatment of
patients with locally
advanced or metastatic
NSCLC after failure of at
least one prior
chemotherapy regimen.
Restricted to non-smoker,
female, epidermal growth
factor receptor (EGFR)
positive and Asian patients
only

(Iressa)

31

Erlotinib 150 mg Tablet


(Tarceva)

32

Erlotinib 100 mg Tablet


(Tarceva)

A*

52

Remark
RM110/vial

RM330.60/
vial

150 mg taken at least one hour before RM177.33/tab


or two hours after the ingestion of
food. Reduce in steps of 50 mg when Borang E
necessary. Continue treatment until
disease progression or unacceptable
toxicity occurs. May require dose
modifications when coadministered
with strong CYP3A4 inhibitors or
inducers; or in cigarette smoking
patients.
RM143.23/tab

Borang E

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
33 Lapatinib 250 mg Tablet
(Tykerb)

Cat Indications
A* In combination with:
i) capecitabine, for the
treatment of patients with
advanced or metastatic
breast cancer whose tumors
overexpress HER2 and who
have received prior therapy
including an anthracycline, a
taxane, and trastuzumab.
ii) letrozole for the treatment
of postmenopausal women
with hormone receptor
positive metastatic breast
cancer that overexpresses
the HER2 receptor for whom
hormonal therapy is
indicated.

Dosage
i) 1,250 mg (5 tablets) once daily on
Days 1-21 continuously in combination
with capecitabine 2,000 mg/m2/day
(administered orally in 2 doses
approximately 12 hours apart) on
Days 1-14 in a repeating 21 day cycle.
ii) 1500 mg (6 tablets) once daily
continuously in combination with
letrozole. When TYKERB is
coadministered with letrozole, the
recommended dose of letrozole is
2.5mg once daily.

Remark
RM28.36/tab

KPK
(Patient
basis)

34

Hydroxyurea 500 mg
Capsule

i)Solid tumours
ii) Chronic myelocytic
leukaemia and
myeloproliferative disease
iii)Severe psoriasis eg.
Extensive plaque psoriasis,
erythrodermic psoriasis,
pustular psoriasis -as third
line therapy.

i) Intermittent therapy : 80 mg/kg orally


as a single dose every 3rd day.
Continuous therapy : 20-30 mg/kg
orally as a single dose dly.
Concomitant therapy with irradiation :
80 mg/kg orally as a single dose every
3rd day.(administration of hydroxyurea
should be started at least 7 days
before initiation of irradiation and
continued during radiotherapy as well).
ii) Continuous therapy (20 - 30 mg/kg
orally as a single dose daily, therapy
should be interrupted if the white
blood cell count drops below
2500/mm3, or the platelet count below
100,000/mm3.
iii) 500 mg tds.

RM1.07/cap

35

Irinotecan HCl Trihydrate


100mg/5ml Injection

A*

Only for patients with


colorectal cancer who:
i) have relapsed within 6
mths after the end of
adjuvant chemotherapy with
5-fluorouracil-based regime
ii) have progressive disease
despite 5-fluorouracil
chemotherapy for advanced
disease
iii) good performance status
(WHO of 2 or less) The
treatment must be given in a
tertiary oncology centre or
have clearance in writing by
an oncologist

In combination therapy (for previously


untreated patients): 180 mg/m2 once
every 2 wks as an IV infusion over 90
mins followed by infusion with folinic
acid and 5-fluorouracil.
In monotherapy (for previously treated
patients): 350 mg/m2 administered as
an intravenous infusion over 90 mins
period once every 3 wks

RM150/vial

53

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

L02 Endocrine Therapy


No Generic Name
1 Leuprolide Acetate 3.75
mg Injection
(Lucrin)
2

Cat Indications
A* i) Endometriosis
ii) Hormonal therapy in
advanced prostate cancer

Goserelin 3.6 mg Depot


Injection
(Zoladex)

Goserelin 10.8 mg Depot


Injection
(Zoladex)

Triptorelin 3.75 mg
Injection

(Decapeptyl)

Prostate cancer,
endometriosis, leiomyoma
uteri and assissted
reproduction, breast cancer
in premenopausal and
perimenopausal women
suitable for hormonal
manipulation

Dosage
i) 3.75 mg mthly for 3 - 6 mths
ii) 3.75 mg IM or SC injection mthly

RM292.50/ea

Remark

3.6 mg depot injection every 28 days

RM270.00/ea

Borang E
One 10.8mg depot injected
subcutaneously into the anterior
abdominal wall, every 12 weeks.

RM911.80/ea

Treatment of confirmed
central precocious puberty
(preterm sexual
development) in girls < 9
yrs, boys < 10 yrs

3.75 mg IM injection every 4 wks.


Period of treatment should not exceed
6 mths

RM309.00/ea

20-40 mg dly

RM0.37/tab

Borang E

Tamoxifen Citrate 20 mg
Tablet

Breast cancer

Bicalutamide 50 mg
Tablet
(Casodex)

A*

RM6.78/tab
Advanced prostate cancer 50 mg once daily. (morning or
in combination with LHRH
evening), with or without food. Take on
Borang E
analogue therapy or surgical the same time each day.
castration.

Anastrozole 1 mg Tablet

A*

Treatment of hormone
responsive metastatic or
locally advanced breast
cancer after failure of
tamoxifen

1 mg dly

Treatment of hormone
responsive metastatic or
locally advance breast
cancer after failure of
tamoxifen

2.5 mg od

(Arimidex)

Letrozole 2.5 mg Tablet

A*

(Femara)

Exemestane 25 mg
Tablet
(Aromasin)

L03 Immunostimulants
No Generic Name
1 Filgrastim (G-CSF) 30
MU/ml Injection
(Neupogen)

A*

Borang E

54

RM17.83/tab

Borang E

Treatment of post25 mg once daily


menopausal women with
advanced breast cancer
whose disease has
progressed following
tamoxifen and non-steroidal
aromatase inhibitors

Cat Indications
A* i) Reduction in the duration
of neutropenia and
incidence of febrile
neutropenia in cytotoxic
chemotherapy for
malignancy except chronic
myeloid leukemia and
myelodysplastic syndrome
ii) Haemopoeitic stem cell
transplantation (HSCT)/
stem cell harvesting

RM1.90/tab

RM20.60/tab

1 patient

Dosage
Remark
RM168.20/
i) Adult: SC or IV 5 mcg/kg/day.
vial
Initiation: 24 - 72 hrs after
chemotherapy.
Duration: Until a clinically adequate
neutrophil recovery is achieved
(absolute neutrophil count of at least 1
x 109/L on 2 consecutive days)
ii) Refer to protocol

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

L04 Immunosuppressive Agents


No Generic Name
Cat Indications
1 Mycophenolate Mofetil
A* i) Prophylaxis of acute
500 mg tablet (Cellcept)
organ rejection in patients
receiving allogenic renal,
cardiac and hepatic
transplant
ii) Used with steroids for
induction and maintenance
of severe lupus nephritis
resistant or intolerant to
cyclophosphamide therapy
2

Mycophenolate Sodium
180mg Tablet (Myfortic)

A*

Mycophenolate Sodium
360mg Tablet (Myfortic)

A*

Ciclosporin 25 mg
Capsule Microemulsion

A*

(Sandimmun Neoral)

Ciclosporin 100 mg
Capsule Microemulsion

A*

(Sandimmun Neoral)

Tacrolimus 1 mg Capsule
(Prograf)

A*

Tacrolimus 5 mg Capsule
(Prograf)

A*

Azathioprine 50 mg
Tablet (Imuran)

Dosage
Remark
i) Renal transplant rejection:
RM6.64/tab
ADULT: 1 g bd.
CHILD (3 mths and older): 600
Borang E
mg/m(2)/dose, bd; max: 2 g/10
mL/day.
Cardiac transplant rejection: 1.5 g bd.
Hepatic transplant rejection: 1.5 g bd
ii) Induction phase: 2-3 g/day for up to
6 mths. Maintenance phase: dose
gradually tapers to 1 g/day

Prophylaxis of acute
720 mg bd
transplant rejection in adult
patients receiving allogenic
renal transplant in
combination with ciclosporin
and corticosteroids

RM3.27/tab

Only for: i) Patients in whom


donor specific
transplantation cannot be
carried out and in young
children to minimise sideeffects of steroids.
ii) Follow-up cases of bone
marrow transplant
iii) Patients with severe
rheumatoid arthritis not
responding to other second
line drugs.
iv) Patients with idiopathic
nephrotic syndrome who are
steroid toxic or poor
response to
cyclophosphamide.
v) Severe aplastic anemia,
pure red cell aplasia
vi) Cases of recalcitrant
psoriasis and atopic eczema
vii) Treatment of chronic
ocular inflammatory
disorders/uveitis

i & ii) Initially 12.5 - 15 mg/kg/day,


beginning on the day before
transplant. Maintenance approx 12.5
mg/kg/day for 3-6 mths before being
tapered off to zero by 1 yr of
transplantation.
iii) 3 mg/kg/day in 2 divided doses for
first 6 wks. May increased gradually to
max 5 mg/kg. Treatment withdrawn if
no response after 3 mths.
iv) ADULT: 5 mg/kg/day in 2 divided
doses. PAED: 6 mg/kg/day in 2
divided doses. Patients with permitted
levels of kidney failure, the starting
dose must < 2.5 mg/kg/day.
v) 12 mg/kg/day.
vi) 2.5 mg/kg/day in 2 divided doses
increasing if there is no improvement
after 4 wks by 0.5 -1 mg/kg/mth up to
max 5 mg/kg/day.
vii) 5 mg/kg/day in 2 divided doses,
may increase to 7 mg/kg/day in
resistant cases. Maintenance: < 5
mg/kg/day especially during remission

RM3.24/cap

i) Primary
immunosuppressant agent
for all solid organ
transplantation
ii) Rescue therapy for
rejection

i) 0.2 mg/kg/day in 2 divided doses


ii) 0.3 mg/kg/day in 2 divided doses

RM8.99/cap

i)Acute leukaemia
i) 1-4 mg/kg/day
ii)Immunosuppressive agent ii) 1.5-2 mg/kg/day

55

Borang E
RM6.55/tab

Borang E

RM12.94/cap

Borang E
RM45.19/cap

Borang E
RM1.24/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

MUSCULO-SKELETAL SYSTEM

M01 Antiinflammatory and Antirheumatic Products


No Generic Name
Cat Indications
1 Indomethacin 25 mg
B Pain and inflammation in
Capsule (Indocid)
rheumatic disease

Dosage
Remark
50 - 200 mg dly in divided doses, with RM0.05/tab
food. Child not recommended.
RM0.38/amp

Diclofenac Sodium
75mg/3ml Injection
(Voltaren)

Pain and inflammation in


rheumatic disease

75 mg od (bd in severe cases) for < 2


days

Diclofenac Sodium 50 mg
Tablet
(Voltaren)

Pain and inflammation in


rheumatic disease and
juvenile arthritis

RM0.02/tab
75 - 150 mg dly in divided doses.
CHILD 1-12 yrs, Juvenile arthritis; 12.525 mg dly

Meloxicam 7.5mg Tablet


(Mobic)

i) initially 7.5 mg dly. May be increased


to 15 mg dly
ii) initially 15 mg dly. May be reduced
to 7.5 mg dly. Max: 5 mg dly. Child <
12 yrs not recommended

RM0.08/tab

Pain and inflammation in


rheumatic disease

ADULT : 200-400 mg tds after food,


max: 2.4 g dly CHILD : 20-30 mg/kg
dly in divided doses

RM0.07/tab

A/KK i) Rheumatic arthritis,


osteoarthritis and
ankylosing spondylitis
ii) Acute gout
iii) Muscular skeletal
disorder, dysmenorrhoea

i) 0.5 - 1 g dly in 2 divided doses


ii) 750 mg initially then 250 mg tds
iii) 500 mg initially then 250 mg tds qid as required

RM0.07/tab

A/KK Only for patients not


responding to other NSAIDs
in the treatment of
i) painful osteoarthritis
ii) rheumatoid arthritis

Ibuprofen 200 mg Tablet


(Brufen)

Naproxen 250 mg Tablet

Mefenamic Acid 250 mg


Capsule
(Ponstan)

Mild to moderate pain

ADULT: 250-500 mg tds after meals.


CHILD > 6 mths: 6.5 - 25 mg/kg dly
tds - qid for not longer than 7 days
except in juvenile arthritis

RM0.14/cap

Celecoxib 200 mg
Capsule

A*

i) Osteoarthritis
ii) Rheumatoid Arthritis
iii) Acute pain
iv) Ankylosing Spondylitis

i) ADULTS : 200 mg od.


ii) 100 mg bd, increased if necessary
to 200 mg bd; CHILD not
recommended
iii) 400 mg as a single dose on first
day followed by 200 mg od on
subsequent days,
iv) Initial, 200 mg od or 100 mg bd; if
no effect after 6 wks, may increase to
max. 400 mg dly in 1-2 divided doses.
If no response following 2 wks of
treatmetn with 400 mg/day, consider
discontinuation and alternative
treatment

RM1.74/cap

(Celebrex)

Celecoxib 400 mg
Capsule

A*

(Celebrex)

Parecoxib Sodium 40mg


Injection

RM2.99/cap

A*

Management of post
operative pain in the
immediate post operative
setting only

40 mg followed by 20 or 40 mg every 6
to 12 hrs, as required. Use limited to 2
days only with a max: 80 mg/day.
Reduce the initial dose by 50% in
elderly < 50 kg

RM23.25/ea

i) Acute and chronic


treatment of signs and
symptoms of osteoarthritis
(OA) and rheumatoid
arthritis (RA)
ii) Acute gouty arthritis
iii) Acute pain

i) OA: 60 mg od. RA: 90 mg od


ii) & iii) Acute gouty arthritis and acute
pain: 120 mg od (Given the exposure
to COX-2 inhibitors, doctors are
advised to use the lowest effective
dose for the shortest possible duration
of treatment)

RM1.87/tab

(Dynastat)
10

Etoricoxib 90 mg Tablet
(Arcoxia)

A*

11

Etoricoxib 120 mg Tablet


(Arcoxia)

A*

56

RM3.32/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

M02 Topical Products for Joint And Muscular Pain


No Generic Name
Cat Indications
Dosage
1 Diclofenac 1% Emulgel
A Post-traumatic inflammation Apply tds - qid and gently rubbed in
of the tendons,ligaments &
joints. Localised forms of
soft tissue rheumatism and
degenerative rheumatism
2

Methyl Salicylate 25%


Ointment

M03 Muscle Relaxants


No Generic Name
1 Suxamethonium Chloride
50 mg/ml lnj

Relief of pain associated


with musculoskeletal
discomfort

To be applied to affected area

Remark
RM1.45/ea

RM20.41/
500gm

Cat Indications
B Muscle relaxant as an
adjunct to anaesthesia

Dosage
Remark
Initial test dose 5-10 mg may be given. RM4.43/amp
Usual single dose 0.3 - 1.1 mg/kg IV.
Max: 100 mg according to the depth
and duration of relaxation required. 2.5
- 4 mg/kg IM, max: 150 mg
ADULT: 80-100 mcg/kg IV.
Maintenance 20-30 mcg/kg acording
to response.
NEONATE and INFANT up to 4 mths:
Initially 10-20 mcg/kg, then
incremental dose to achieve response

RM24.75/ vial

RM6.12/amp

(Scoline)

Vecuronium Bromide 10
mg/10 ml Injection

A*

Vecuronium Bromide 4
mg/ml Injection

A*

Atracurium Besylate 50
mg/5 ml Injection

A*

Muscle relaxation

ADULT and CHILD > 1 mth: Initially


300 - 600 mcg/kg IV injection.
Subsequent doses of 80 - 200 mcg/kg
may be given as necessary. IV
infusion: 5 - 10 mcg/kg/min (300 - 600
mcg/kg/hr)

Rocuronium Bromide 10
mg/ml Injection

A*

As an adjunct to general
anaesthesia to facilitate
endotracheal intubation, to
provide skeletal muscle
relaxation during surgery
and to facilitate mechanical
ventilation in adults, children
and infants from 3 mths of
age

RM18.83/ea
ADULT (usual) : Intubation: (rapid
sequence intubation) initial, 0.6-1.2
mg/kg IV Intubation: (tracheal
intubation) initial, 0.6 mg/kg IV
Intubation: maintenance, 0.1-0.2
mg/kg IV repeated as needed.
Intubation: maintenance, 0.01-0.012
mg/kg/minute continuous IV infusion.
Skeletal muscle relaxation: initial, 0.6
mg/kg IV, maintenance, 0.1-0.2 mg/kg
IV repeated as needed or 0.01-0.012
mg/kg/minute continuous IV infusion.
CHILD: (usual) Intubation: (age 3 mths12 yr) initial, 0.6 mg/kg/dose IV,
maintenance, 0.075-0.125 mg/kg IV as
needed or 0.012 mg/kg/min
continuous IV infusion. Skeletal
muscle relaxation: (age 3 mths-12 yr)
initial, 0.6 mg/kg/dose IV,
maintenance, 0.075-0.125 mg/kg IV as
needed or 0.012 mg/kg/min
continuous IV infusion

Myotonic symptoms
associated with cervical
syndrome, periarthritis of
shoulder and lumbago
spastic paralysis

50 mg tds

RM0.72/tab

Spasticity of the skeletal


muscle

ADULT: 5 mg tds. Max: 80 mg dly.


CHILD: 0.75 - 2 mg/kg dly (> 10 yrs,
max: 2.5 mg/kg dly)

RM0.68/tab

(Esmeron)

Eperisone HCl 50 mg
Tablet
(Myonal)

Baclofen 10 mg Tablet

As an adjunct in
anaesthesia to produce
skeletal muscle relaxation

57

RM5.80/amp

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

M04 Antigout Preparations


No Generic Name
Cat Indications
1 Allopurinol 300 mg Tablet A/KK i) Frequent and disabling
attacks of gouty arthritis (3
or more attacks/year).
ii) Clinical or radiographic
signs of erosive gouty
arthritis. iii) The presence of
tophaceous deposits.
iii) Urate nephropathy.
iv) Urate nephrolithiasis.
v) Impending cytotoxic
chemotherapy or
radiotherapy for lymphoma
or leukaemia
2

Colchicine 0.5 mg Tablet

i) Acute gout and


prophylaxis of recurrent
gout. ii) Leucocytoclastic
Vasculitis either cutaneous
or systemic involvement,
Behcet's syndrome,
Urticarial vasculitis,
Systemic sclerosis, Sweet's
syndrome and severe
recalcitrant aphthous
stomatitis

M05 Drugs for Treatment of Bone Diseases


No Generic Name
Cat Indications
1 Pamidronate Disodium
A* Hypercalcaemia of
30 mg Injection
malignancy (tumour induced hypercalcaemia)
2

Ibandronic Acid 150 mg


Tablet
(Bonviva)

A*

Zoledronic Acid 4 mg
Injection

Alendronate Sodium
70mg and Cholecalciferol
5600 IU Tablet
(Fosamax Plus)

i)Initial dose, 0.5-1.2 mg, then 0.5-0.6


mg every hr until relief of pain is
obtained or vomiting or diarrhoea
occurs (Max : 8 mg). The course
should not be repeated within 3 days.
Prevention of attacks during initial
treatment with allopurinol or uricosuric
drugs: 0.5 mg od - tds.
ii) 0.5 mg od - tds depends on disease
and severity, up to a max: 3 mg/day

Dosage
Dose depends on the initial serum
calcium levels. Doses range from a
single infusion of 30 - 90 mg

Mecobalamin 500 mcg


Tablet (Methylcobal)

RM0.07/tab

Remark
RM89.00/ea

RM86.28/tab

150 mg once monthly

A*

i) Treatment of
hypercalcaemia of
malignancy
ii) Prevention of skeletal
related events in patients
with multiple myeloma
involving multiple bone
lesion

RM800.00/ea
4 mg reconstituted and should be
given as a 15 mins IV infusion every 3Borang E
4 wks

A*

Osteoporosis in post
menopausal women with a
history of vertebral fracture
and whom oestrogen
replacement therapy is
contraindicated

1 tablet once wkly [contains


cholecalciferol 2800 units in a wkly
dose, equivalent to 400 units dly].

KBUK

M09 Other Drugs For Disorders Of The Musculo-Skeletal System


No Generic Name
Cat Indications
Dosage
1 Prolase Tablet
B Oedema and inflammation 2 tablet tds
(Papese)
in conjunction with other
physical or
chemotherapeutic measures
2

Remark
RM0.14/tab

Treatment of
postmenopausal
osteoporosis to reduce the
risk of fracture.

(Zometa)

Dosage
Initial dose : 100-300 mg dly.
Maintenance : 300-600 mg dly.
Max: 900 mg dly

Peripheral neuropathies

58

1 tablet tds.

RM21.25/tab

KBUK

Remark
RM0.03/tab

RM0.11/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

NERVOUS SYSTEM

N01 Anaesthetics
No Generic Name
1 Ether Solvent
2

Desflurane Liquid

Cat Indications
Dosage
C To remove adhesive plaster Dose depending on the route and
from the skin
procedure
A

(Suprane)

Remark
RM28.53/unit

i) Induction and
maintenance of anaesthesia
in adult ii) Maintenance of
anaesthesia in infants &
children

ADULT: Induction , initially 3% in


oxygen or nitrous oxide/oxygen and
increased by 0.5%-1% every 2-3
breaths or as tolerated (up to 11%),
until loss of consciousness.
Maintenance: 2.5%-8.5% with or
without concomitant nitrous oxide
CHILD: maintenance, inhaled in
concentrations of 5.2%-10% with or
without concomitant nitrous oxide

RM492.00/240
ml

Borang E

Sevoflurane Liquid

A*

To be used only for


i) induction and
ii) maintenance of
anaesthesia

i) Up to 8% in oxygen or nitrous oxideoxygen mixture


ii) maintenance: 1 - 3%

RM338.40/
250ml

Fentanyl Citrate 50
mcg/ml Injection

Analgesia during operation,


relief of pain in the
immediate postoperative
period. Adjunct in
maintenance of general /
regional anaesthesia.

Dose should be individualized


according to age, body weight,
physical status, underlying
pathological conditions and type of
surgery and anaesthesia.
With spontaneous respiration, 50 200 mcg, then 50 mcg every 20 - 30
min as required.
With assisted respiration: 0.3 - 3.5 mg,
then 100-200 mcg as required up to
600 mcg. CHILD:Child with
spontaneous respiration: 3-5 mcg/kg,
then 1 mcg/kg as required. Child with
assisted ventilation : 10-15 mcg/kg,
then 1 - 3 mcg/kg as required

RM1.56/amp

Ketamine 50 mg/ml
Injection

Sole anaesthetic for short


IV - onset 30 sec : 2 mg/kg or
procedures or induction of IM - onset 3-4 min : 10 mg/kg
anaesthesia in certain types
of patients (e.g in shock
states)

Etomidate 20mg Injection

A*

Induction of general
CHILD > 10 yrs and ADULT: 0.15 - 0.3 RM15/unit
anaesthesia for
mg/kg
haemodynamically unstable ELDERLY: 0.15 - 0.2 mg/kg
KPK
patients

Propofol 1 % Injection

A*

Induction & maintenance of


general anaesthesia.
Sedation of ventilated ICU
patients

Induction: 1.5-2.5mg/ kg at the rate of


20-40 mg every 10 sec. CHILD > 8
yrs: usually 2.5mg/ kg. Maintenance:
IV 25-50 mg repeated according
response. IV infusion: 4-12mg/kg/hr;
CHILD > 3 yrs: 9-15 mg/kg/ hr.
Sedation: 0.3 - 4 mg/kg/hr up to 3
days

RM4.06/vial

For peripheral sympathetic


nerve and epidural
(excluding caudal)
anaesthesia and obstetrics
anaesthesia

Regional nerve block or epidural


block: 15 - 30 ml. Nerve block of finger
or toe: 2 - 6 ml. Max: 2 mg/kg in any 4
hrs period, equivalent to 25 - 30 ml in
adults of average weight

RM5.09/ea

Used for spinal anaesthesia ADULT: 2 - 4 ml. Not to exceed 2


mg/kg in a single dose

(Diprivan)

Bupivacaine 0.5 %
Injection
(Marcaine)

Bupivacaine 0.5 % Heavy


Injection

59

RM9.86/vial

RM17.01/ea

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
10 Lignocaine 10 % w/w
Spray

Cat Indications
B For surface anaesthesia in
dental practice, in
otorhinolaryngology and
paracentesis

Dosage
Spray to affected part

Remark
RM35.41/
50ml

11

Lignocaine 2 % Jelly

Use for endotracheal tubes Apply to affected area 10 mins before


and instruments, painful
catheterization, etc
procedures in the ear, nose
and throat, burns, wounds,
abrasions, lacerations;
catheterisation of the male
and female urethra and for
symptomatic treatment of
cystitis and urethritis

RM3.94/tube

12

Lignocaine (Lidocaine)
HCl 2 % Injection

Local anesth by infiltration


IV regional anesthesia and
nerve block. Emergency
management of ventricular
arrhythmias particularly after
myocardial infarction and
cardiac surgery

Local anesthesia :
ADULT Max: 200 mg;
CHILD Max: 30 mg/kg
Cardiac arrhythmias : ADULT 50-100
mg IV. Max: 200-300 mg/hour;
CHILD LD: 0.8-1 mg/kg IV repeated if
necessary up to 3-5 mg/kg followed by
a continuous infusion of 10-50
mcg/kg/min

RM1.83/ea

13

Ropivacaine HCl 7.5


mg/ml Injection

A*

i) Surgical anaesthaesia
including obstetrics
ii) Acute pain management

RM25.20/ea
Dose adjusted according to patient
physical status and nature of
procedure.
i) Lumbar epidural: 15-25 ml of 7.5
mg/ml solution; Caesarean section, 1520 ml of 7.5 mg/ml solution in
incremental doses ( max total dose
150 mg).
ii) lumbar epidural: 10-20 ml of 2mg/ml
solution followed by 10-15 ml of 2
mg/ml solution at interval at of least 30
minutes. Labour pain 6-10 ml/hr of
2mg/ml solution

10 - 40 ml (0.25 %) or max : 2 mg/kg


in any 4 hrs period, equivalent to 25 30 ml of 0.5% solution

(Naropin)

RM20.20/amp

14

Bupivacaine 0.5 % with


Adrenaline 1:200,000
Injection

Regional nerve block or


epidural block.

15

Lidocaine 25mg and


Prilocaine 25mg Cream

Used for painless


Apply a thick layer under occlusive
venepunctures, radial artery dressing at least 1 hr before the
cannulations before
procedure
extradural/spinal and other
regional blocks in children
above 1 year old and adults.
Also used in chronic renal
failure patients for insertion
of A-V fistulas and shunts
for haemodialysis.

RM8.08/5gm

To produce local
anaesthesia or
vasoconstriction during
endoscopic nasal surgery,
turbinectomy septoplasty,
polypectomy etc

RM5.57/gm

(EMLA)

16

Cocaine 10% Solution

60

Max. total dose recommended for


application to the nasal mucosa in
healthy adult is 1.5 to 2 mg/kg of a
10% cocaine solution

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
17 Ethyl Chloride Spray

N02 Analgesics
No Generic Name
1 Morphine HCl 10 mg/5ml
Solution

Cat Indications
C For minor surgical
procedures including
lancing boils, incision and
drainage of small
abscesses, pain due to
athletic injuries and pain
due to injection
administration

Dosage
Remark
Spray to affected area at a distance of RM10.49/can
about 30cm until a fine white film is
produced

Cat Indications
B For use in management of
moderate to severe pain
especially that associated
with neoplastic disease

Dosage
5 - 20 mg or more regularly every 4
hrs in terminal pain

Remark
RM8.70/g

Morphine Sulphate 10
mg/ml Injection

For moderate to severe pain ADULT: 10 - 20 mg/kg or more SC or RM1.14/amp


especially that associated
IM every 4 hrs in terminal pain. CHILD:
with neoplastic disease
Up to 1 mth: 0.15 mg/kg; 1-2 mths: 0.2
mg/kg; 1-5 yrs: 2.5 - 5 mg ; 6-12 yrs: 510 mg

Oxycodone HCl 5 mg
Immediate Release
Capsules

A*

i) As a second line drug in


the management of opioid
responsive, moderate to
severe chronic cancer pain
ii) As a step-down analgesic
drug in post-operative
procedures

Initially 5 mg every 4 to 6 hours,


increased if necessary according to
severity of pain, usual max. 400 mg
daily, but some patients may require
higher doses

RM0.80/tab
Surgical cancer pain,
PRN basis (6
pts/mth)
Ortho - max 3
days after
operation

Management of moderate to
severe chronic cancer pain
non-responsive to morphine
(in accordance with WHO
step-wise ladder of chronic
pain management)

ADULT, ELDERLY and CHILDREN >


18 yrs, opioid-naive patients: 10 mg
bd. Renal or hepatic impairment: 5 mg
bd. Titrate dose carefully, as
frequently as once a day if necessary,
to achieve pain relief

RM2.79/tab

For relief of moderate to


severe pain (medical and
surgical), pre-anaesthetic
medication and obstetrical
analgesia

ADULT: 0.5 - 2 mg/kg SC or IM every


3-4 hrs if necessary. CHILD: by IM 0.5
- 2 mg/kg. Up to 1 yr : 1-2 mg/kg IM, 15 yrs : 12.5 - 25 mg IM, 6-12 yrs: 2550 mg IM

RM1.11/amp

As a second line drug in the


management of chronic
cancer pain. The use is to
be restricted to pain
specialists, palliative
medicine specialists and
oncologists.

Patients who have not previously


received a strong opioid analgesic,
initial dose , one 25 mcg/hour patch to
be replaced after 72 hrs. Patients who
have received a strong opioid
analgesic, initial dose based on
previous 24 hrs opioid requirement
(oral morphine sulphate 90 mg over 24
hrs = one 25 mcg/hr patch). Not
recommended in children.

RM21.38/ea

(Oxynorm)

Oxycodone HCl 10 mg
Prolonged Release
Tablet (Oxycontin)

A*

Oxycodone HCl 20 mg
Prolonged Release
Tablet (Oxycontin)

A*

Pethidine HCl 50 mg/ml


Injection

Pethidine HCl 100 mg/2


ml Injection

Fentanyl 25 mcg/h
Transdermal Patch

A*

Tramadol HCl 50 mg
Capsule
(Tramal)

10

Tramadol HCl 50 mg/ml


Injection
(Tramal)

A/KK Post-operative pain, chronic 50 - 100 mg every 4 hrs. Max 400 mg


cancer pain, analgesia/pain daily. Not recommended in children
relief for patients with
impaired renal function
A

Post-operative pain, chronic


cancer pair and
analgesia/pain relief for
patients with impaired renal
function
61

ADULT: By IM / IV inj. (over 2-3 mins)


or by IV infusion. Initially 100 mg then
50 - 100 mg every 4 - 6 hours. Max:
600 mg daily. Child not recommended

RM5.37/tab

RM1.36/amp

RM0.06/cap

RM0.95/amp

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
11 Acetylsalicylic Acid,
Soluble 300 mg Tablet
(Aspirin)
12 Paracetamol 120 mg/5 ml
Syrup

Cat Indications
C Mild to moderate pain

Mild to moderate pain and


pyrexia

Dosage
Remark
RM0.10/tab
300-900 mg every 4 - 6 hrs as
required. Max 4 g daily. Use in
children not recommended
CHILD: up to 1 yr: 6-120 mg. 1-5 yrs: RM2.49/60ml
120-240 mg. 6-12 yrs: 240-480 mg per
dose. Repeat every 4-6 hrs when
necessary. Max of 4 doses in 24 hrs
RM0.29/supp

13

Paracetamol 250 mg
Suppository

Symptomatic relief of fever


and post operative pain for
paediatric cases

CHILD 1-5 yrs: 125-250 mg; 6-12 yrs:


250-500 mg; 3-11 mths: 80 mg
inserted every 4 - 6 hrs if necessary,
max. 4 doses in 24 hrs. INFANTS
under 3 mths should not be given
Paracetamol unless advised by doctor;
a dose of 10 mg/kg (5 mg/kg if
jaundiced) is suitable

14

Paracetamol 500 mg
Tablet
Pizotifen 0.5 mg Tablet

Mild to moderate pain and


pyrexia
Prophylactic treatment of
vascular headache

ADULT: 500 - 1000 mg every 4-6 hrs, RM0.18/tab


max of 4 g dly
ADULT: 0.5 mg in the evening for first RM1.87/tab
2 days, then 0.5 mg mid-day and
evening for next 2 days, then 0.5 mg 3 Borang E
times daily. CHILD: Up to 1.5 mg daily
in divided doses

15

(Sandomigran)

N03 Antiepileptics
No Generic Name
1 Phenobarbitone 30 mg
Tablet

Cat Indications
B Epilepsy

Dosage
Remark
ADULT: 60-180 mg dly on. CHILD: Up RM0.11/tab
to 8 mg/kg dly

Phenobarbitone Sodium
200 mg/ml Injection

Status Epilepticus

ADULT: 10 mg/kg IV at a rate of not


faster than 100 mg/min. Initial max
dose does not exceeding 1 gm. Dly
maintenance of 1-4 mg/kg/day.
CHILD: 10-20 mg/kg/dose LD,
followed by repeated doses at 10
mg/kg/dose (strictly in ICU setting).
Maintenance 5 - 8 mg/kg/day

RM14.40/amp

Phenytoin Sodium 100


mg Capsule

Epilepsy

ADULT and CHILD > 6 yrs: 300-400


mg/day in 3-4 divided doses before
meals. Max: 600 mg/day. CHILD:
Initially 5 mg/kg/day in 2-3 divided
doses. Maintenance: 4-8 mg/kg/day.
Max: 300 mg/day

RM0.19/cap

Phenytoin Sodium 250


mg/5ml Injection

Status epilepticus

i) Status epilepticus: ADULT 10-15


mg/kg by slow IV. Max 50 mg/min.
Maintenance: 100 mg orally/IV tds qid. CHILD 15-20 mg/kg by slow IV.
Max: 1-3 mg/kg/min
ii) Neurosurgery 100-200 mg IM
approximately at 4 hrly interval

RM26.44/vial

Clonazepam 2 mg Tablet

i) Epilepsy
ii) Non-epileptic myoclonus

i) ADULT: Initially, 1 mg given at night


for 4 nights, gradually increased over
2-4 wk. Elderly: 500 mcg.
Maintenance: 4-8 mg dly. Max: 20
mg/day. CHILD: 5-12 yrs: Initially, 0.5
mg dly; 1-5 yrs: 0.25 mg dly.
Maintenance (given in 2-4 divided
doses): 5-12 yr: 3-6 mg dly; 1-5 yrs: 13 mg dly; infants: 0.5-1 mg dly. Max:
200 mcg/kg/day.
ii) ADULT: Initially, 250 mcg bd,
increased after 3 days up to 1 mg dly.
Max: 4 mg dly

RM0.20/tab

62

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
6 Carbamazepine 200 mg
Tablet

Cat Indications
B i) Epilepsy
ii) Trigeminal neuralgia

(Tegretol)

Epilepsy

Dosage
Remark
RM0.30/tab
i) ADULT: 100-200 mg od - tds
increased gradually to usual dose of
0.8 - 1.2 g dly in divided doses.
CHILD: Up to 1 yr: 100-200 mg dly; 15 yrs: 200 - 400 mg dly; 5-10 yrs: 400 600 mg dly; 10-15 yrs: 0.6 - 1 g dly ii)
ADULT: Initially, 100 mg od or bd
gradually increased as necessary.
Maintenance: 400-800 mg dly in 2-4
divided doses. Max: 1.2 g dly
ADULT: Initial, 200 mg bd for the first
wk, may increase dosage by 200
mg/day at wkly intervals until optimal
response is obtained. Max: 1.6 g/day.
CHILD: usual max. dosage 1000
mg/day in children 12-15 yrs, 1200
mg/day in patients > 15 yrs

RM0.93/tab

CHILD: > 20 kg. Initially 400 mg/day


with spaced increases until control is
achieved (usually 20-30 mg/kg/day),
dose may be increased to 35
mg/kg/day. < 20 kg, 20 mg/kg/day.
Severe cases: 50 mg/kg dly
ADULT: Initially 600 mg/day in 2 - 3
divided doses, dose may be increased
by 200 mg at 3-day intervals to max
2.5 g/day. Usual maintenance dose: 12 g/day (20-30 mg/kg/day). CHILD: >
20 kg. Initially 400 mg/day with spaced
increases until control is achieved
(usually 20-30 mg/kg/day), dose may
be increased to 35 mg/kg/day. < 20 kg
20 mg/kg/day, in severe cases the
dose may be increased provided
plasma concentration can be
monitored

RM55.30/
300ml

Carbamazepine 200 mg
CR Tablet

Carbamazepine 400 mg
CR Tablet

Sodium Valproate 200


mg/5 ml Syrup

Epilepsy

Epilepsy

i) Adjunctive or
i) Up to 200 mg dly in single or divided
monotherapy for partial
dosage
seizures and generalised
ii) 25- 200 mg dly
tonic-clonic seizures not
satisfactorily controlled with
other antiepileptic drugs
ii) Prevention of mood
episodes in adult 18 years
and above with bipolar
disorder, predominately by
preventing depressive
episodes

RM0.28/tab

Management of seizures in
children aged 2-12 years

RM1.15/tab

(Epillim)

10

Sodium Valproate 200


mg Tablet
(Epillim)

11

Lamotrigine 50 mg Tablet
(Lamictal)

12

Lamotrigine 100 mg
Tablet

(Lamictal)

13

Lamotrigine 5 mg
Dispersible/ Chewable
Tablet

63

a) Add-on therapy in patients not


taking Valproate: wk 1 & 2: 2
mg/kg/day bd, wk 3 & 4: 5 mg/kg/day
bd. Maintenance: 5-15 mg/kg/day bd
b) Add-on therapy in patients taking
Valproate or other anti-epileptic drugs,
wk 1 & 2: 0.2 mg/kg/day as a single
dose (children < 25 kg may take 5 mg
on alternate days), wk 3 & 4: 0.5
mg/kg/day as a single dose.
Maintenance dose: 1 -5 mg/kg/day od
or bd

RM1.70/tab

RM0.21/tab

RM0.46/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
14 Topiramate 15 mg
Capsule Sprinkle

Cat Indications
A* Add-on therapy for
intractable partial epilepsy

15

Topiramate 25mg Tablet


(Topamax)

A*

16

Topiramate 50mg Tablet


(Topamax)

A*

17

Topiramate 100mg Tablet


(Topamax)

A*

Levetiracetam 500mg
Tab

A*

i) Monotherapy therapy in
the treatment of partial
onset seizures with or
without secondary
generalization in patients
from age 16 years of age
with newly diagnosed
epilepsy
ii) Adjunctive treatment in
partial onset seizures with
or without secondary
generalization in adults and
children from 4 years of age
with epilepsy; juvenile
myoclonic epilepsy and
idiopathic generalized tonic
clonic epilepsy from 12
years of age

i) Monotherapy ADULT & Adolescent RM1.53/tab


(from 16 yrs): starting dose: 250 mg
bd, increase dose to 500 mg bd after 2 Borang E
wk. Dose can be further increased by
250 mg bd every 2 wk depending
upon the clinical response. Max: 1500
mg bd
ii) ADULT > 18 yrs & Adolescent (1217 yrs) >50 kg: initially 500 mg bd may
be increased up to 1500 mg bd. Dose
changes can be made in 500 mg bd
increments or decrements 2-4 wkly.
CHILD (4-11 yrs) and Adolescent (1217 yrs) <50 kg: initially 10 mg/kg bd,
may be increased up to 30 mg/kg bd.
dose changes should not exceed
increments or decrements of 10 mg/kg
bd every 2 wks. CHILD >50 kg: Adult
dose

A*

i) Second line treatment of


neuropathic pain in patients
who do not response to first
line drugs
ii) Fibromyalgia

i) Initially, 75 mg bd. May be increased RM3.30/tab


to 150 mg bd after 3-7 days. Max: 600
Borang E
mg/day after an additional 7-day
interval
ii) Initially, 75 mg bd. May be
increased to 150 mg bd within 1 week
or 225 mg bd. Max: 450 mg/day

A*

i) Add-on therapy for


intractable partial epilepsy,
refractory to standard antiepileptic drugs
ii) Treatment of various
types of neuropathic pain,
both peripheral (which
includes diabetic
neuropathy, post-herpetic
neuralgia, trigeminal
neuralgia) in adult > 18 yrs

i) ADULT: 900-1800 mg/day in 3


divided doses. CHILD: 10-40
mg/kg/day in 3 divided doses
ii) ADULT: 900 mg/day in 3 equally
divided doses, max: 3600 mg/day.
Initiate therapy with 300 mg od on Day
1, 300 mg bd on Day 2, 300 mg tds on
Day 3. Thereafter, the dose may be
increased in 3 equally divided doses
up to max. 3600 mg/day

18

Pregabalin 75 mg
Capsule
(Lyrica)

20

Gabapentin 300 mg
Capsule
(Neurontin)

RM2.15/tab

Borang E

(Keppra)

19

Dosage
Remark
ADULT: 200 - 400 mg/day in 2 divided RM2.06/tab
Borang E
doses. Max:1600 mg/day.
CHILD: initial 25 mg (1-3 mg/kg/day),
RM2.27/tab
then titrated by 1-3 mg/kg/1-2 weeks
Borang E
in 2 divided doses. Maintenance 5-9
RM1.36/tab
mg/kg/day in 2 divided doses
Borang E

64

RM0.13/cap

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

N04 Anti-Parkinson Drugs


No Generic Name
1 Benzhexol 2 mg Tablet

Procyclidine HCl 10 mg/2


ml Injection

Cat Indications
B i) Parkinson's disease
ii) Drug induced
parkinsonism
iii) Dystonias

i) All forms of Parkinson's


disease (idiopathic paralysis
agitants), post-encephalitis
and arteriosclerosis
ii) To control troublesome
extrapyramidal symptoms
induced by neuroleptic
drugs including pseudoparkinsonism, acute
dystonic reactions and
akathisia

By IM injection 5-10 mg repeated if


necessary after 20 min.
Max: 20 mg dly.
By IV injection 5 - 10 mg

RM16.60/vial

Parkinson's disease

RM0.50/tab

Parkinson's Disease

Patients not receiving Levodopa


before, initially 100-125 mg tds - qid
adjusted according to response.
Maintenance: 0.75 -2 g in divided
doses. In patients previously treated
with Levodopa the dose should be
about 20 - 25% of the dose previously
being taken
Initial: 100/25 mg 1-2 times/day,
increase every 3-4 days until
therapeutic effect, optimal dosage:
400/100 mg to 800/200 mg/day
divided into 4-6 doses. Dose: 200/50
mg used only when maintenance
therapy is reached and not to exceed
levodopa 1000-1200 mg/benserazide
250-300 mg per day

(Kemadrin)

Levodopa 100 mg &


Carbidopa 25 mg Tablet

Dosage
Remark
RM0.03/tab
ADULT: Initially 1 mg dly.
Maintenance: 5-15 mg dly in 3-4
divided doses.
CHILD: 0.02 mg/kg/dose tds, gradually
increasing to 0.1 - 0.3 mg/kg/dose

(Sinemet)

KPK

RM1.06/cap

Levodopa 100 mg,


Benserazide 25 mg HBS
capsule (Madopar HBS)

Levodopa 200 mg,


Benserazide 50 mg
Tablet (Madopar)

Amantadine HCl 100 mg


Tablet

Parkinson's disease

RM0.75/tab
Initial dose: 100 mg daily and is
increased to 100 mg bd (not later than
4 p.m.) after a week. Elderly > 65 yrs: Borang E
< 100 mg or 100 mg at intervals of
more than 1 day

Pramipexole
Dihydrochloride 0.125 mg
Tablet

A*

Treatment for signs and


symptoms of advanced
idiopathic Parkinson's
disease. It may be used as
monotherapy or in
combination with levodopa

Dose escalation: 0.125 mg tds on wk 1 RM1.06/tab


then 0.25 mg tds wk 2 then 0.5 mg tds
on wk 3. Increase by 0.75 mg at wkly Borang E
intervals if needed up to max. of 4.5
mg/day. Patient on levodopa:
Reduced dose. Renal impairment:
Clcr: 20-50 ml/min: initially 0.125 mg
bd, Clcr < 20 ml/min initially 0.25 mg
dly as a single dose, max: 1.5 mg bd

(Sifrol)

RM0.80/tab

Selegiline HCl 5 mg
Tablet

A*

Only for treatment of late


5 mg bd at breakfast and lunch.
stage Parkinsonism with on Max: 10 mg/day
and off phenomenon

RM0.64/tab

Entacapone 200 mg
Tablet

Parkinson's Disease. An
adjunct to standard
levodopa/benserazide or
levodopa/carbidopa for use
in patients with parkinson's
disease and end of dose
motor fluctuations, who
cannot be stabilised on
those combinations
65

RM3.70/tab

(Comtan)

200 mg to be taken with each dly dose


of levodopa/dopa-decarboxylase
inhibitor. May be taken with or without
food

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

N05 Psycholeptics
No Generic Name
1 Chlorpromazine HCl 25
mg Tablet

Cat Indications
B Psychosis mania and
agitation

Dosage
ADULT : Initial dose - 25 mg tds
according to response up to 1 g dly.
PAEDIATRIC: Up to 5 yrs: 0.5 mg/kg
every 4-6 hrs (Max: 40 mg dly).
CHILD 6-12 yrs: A third to half adult
dose (Max: 75 mg dly)

Remark
RM0.17/tab

RM0.13/tab

Chlorpromazine HCl 100


mg Tablet

Fluphenazine Decanoate
25 mg/ml Injection

Long term management of


psychotic disorders

By deep IM : Test dose 12.5 mg (6.25


mg in ELDERLY), then after 4-7 days
12.5 mg-100 mg repeated at intervals
of 14-35 days, adjusted according to
response.
CHILD not recommended

RM0.87/amp

Perphenazine 4 mg
Tablet

Schizophrenia and other


psychoses

ADULT: Initially 4 mg tds adjusted


according to response, max: 24 mg
dly. ELDERLY: 1/4 to 1/2 adult dose.
CHILD not recommended

RM0.20/tab

Prochlorperazine
Mesylate 12.5mg/ml
Injection
(Stemetil)

i) Severe nausea and


vomiting
ii) Vertigo/labyrinthine
disorders

Deep IM injection, 12.5 mg repeated if


necessary after 6 hrs and then
followed by an oral dose. Not
recommended in children

RM1.50/amp

Prochlorperazine Maleate
5mg Tablet

i) Severe nausea and


vomiting
ii) Vertigo/labyrinthine
disorders

i) Injection IM 12.5 mg stat and


repeated if necessary after 6 hrs or
orally 20 mg stat followed by 10 mg
after 2 hrs. Prevention: 5 - 10 mg 2 - 3
times a day. CHILD (> 10 kg only) 250
mcg/kg bd - tds a day
ii) For labyrinthine disorders 5 mg tds,
gradually increased to 30 mg dly in
divided doses, then reduced after
several wks to 5-10mg dly. Not
recommended in children

RM0.03/tab

Psychotic disorder

ADULT: Initially 5 mg bd, increase by


5 mg after 1 wk, then at 3-day
intervals. Max: 40 mg/day.
CHILD up to 12 yrs: Initially up to 5 mg
dly in divided doses adjusted to
response, age and body weight

RM0.21/tab

(Stemetil)

Trifluoperazine HCl 5 mg
Tablet
(Stelazine)

Haloperidol 5 mg/ml
Injection

Acute psychoses and mania ADULT: IM or IV , 2-10 mg then every


4-8 hrs according to response to total
max. 18 mg dly. Use in child is not
recommended

Haloperidol 1.5 mg Tablet

Schizophrenia and other


psychoses

10

Haloperidol 5 mg Tablet

11

Flupenthixol Decanoate
Depot 20 mg/ml lnjection

Chronic psychoses

(Fluanxol)

66

RM310/amp

ADULT : 1.5 -5 mg bd - tds up to 30


mg dly. Paed : Initial: 0.05 mg/kg/day
or 0.25-0.5 mg/day given in 2-3
divided doses; increase by 0.25-0.5
mg every 5-7 days; max: 0.15
mg/kg/day. Maximum 10 mg

RM0.12/tab

By deep IM, initial test dose of 5-20


mg, then after at least 7 days. 20 - 40
mg repeated at intervals of 2-4 wks.
Max. 400 mg wkly. Usual maintenance
dose 50 mg every 4 wks to 300 mg
every 2 wks. ELDERLY, initially
quarter to half adult dose. CHILD not
recommended. Deep IM
recommended. Not for IV use

RM13.34/amp

RM0.03/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
12 Zuclopenthixol 20 mg/ml
Drops

Cat Indications
A* Only for psychoses with
insight or compliance

Dosage
Remark
RM34.39 20ml
Initial: 20-30 mg/day in 2-3 divided
doses. Max. 150 mg dly. Usual
maintenance dose 20-50 mg dly.
Elderly (or debilitated), initially quarter
to half adult dose. CHILD not
recommended. Oral: Zuclopenthixol
dihydrochloride: usual maintenance
dose: 20-40 mg/day; max.100 mg dly

A*

Only for treatment of


agitated and violent patients
suffering from schizophrenia
who are not responding to
the available standard drugs

50-150 mg repeated after 2-3 days if


necessary. Additional dose may be
needed 1-2 days after the first
injection. Max.cumulative dose 400
mg per course and max. 4 injections;
max. duration of treatment 2 wks.
Change to oral dose 2-3 days after the
last injection. Child not recommended

RM14.94/amp

A*

Only for treatment of


agitated and violent patients
suffering from schizophrenia
who are not responding to
the available standard drugs

By deep IM injection test dose 100 mg


followed after 7-28 days by 100 - 200
mg or more followed by 200-400 mg at
intervals of 2-4 wks adjusted
according to response. Max. 600 mg
wkly. Child not recommended

RM19.45/amp

Treatment of resistant
schizophrenia

Initial dose : 12.5 mg (od or bd) dly,


increase slowly in steps of 25-50 mg
up to 300 mg dly within 2-3 wks. Max.
900 mg/day

RM0.45/tab

(Clopixol)

13

Zuclopenthixol Acetate
50 mg/ml Injection
(Clopixol - Acuphase)

14

Zuclopenthixol
Decanoate Depot 200
mg/ml Injection
(Clopixol Depot)

15

Clozapine 25 mg Tablet
(Clozaril)

16

Clozapine 100 mg Tablet


(Clozaril)

17

Olanzapine 5 mg Tablet
(Zyprexa)

A*

18

Olanzapine 10 mg Tablet
(Zyprexa)

A*

19

Olanzapine 5mg
Disintegrating Tablet
(Zyprexa Zydis)
Olanzapine 10 mg
Disintegrating Tablet
(Zyprexa Zydis)
Quetiapine Fumarate 200
mg Extended Release
Tablet

A*

20

21

A*

Quetiapine Fumarate 300


mg Extended Release
Tablet

A*

i)Schizophrenia
ii) Moderate to severe manic
episodes in bipolar disorder
iii) Major depressive
episodes in bipolar disorder

A*

(Seroquel XR)
23

Sulpiride 200 mg Tablet


(Dogmatil)

i) 5-10 mg od, increase to 10 mg od


RM8.04/tab
within 5-7 days, adjust by 5-10 mg/day KBUK
at 1 wk intervals, max. 20 mg/day
RM14.86/tab
ii) 10-15 mg od, increase by 5 mg/day KBUK
at intervals of not less than 24 hrs.
RM7.42/tab
Maintenance 5-20 mg/day; max. 20
KBUK
mg/day
RM13.77/tab

KBUK

(Seroquel XR)
22

i) Acute and maintenance


treatment of schizophrenia
and other psychoses where
positive and or negative
symptoms are prominent
ii) Short-term use for acute
mania episodes associated
with Bipolar 1 disorder

RM1.33/tab
(clozaril RM2.73/tab)

Acute and chronic


schizophrenia, chronic
delusional psychoses

67

i) & ii) 300 mg od (Day 1) then 600 mg


(Day 2). Maintenance dose: 400 to
800 mg od. Max: 800 mg dly
iii) 50 mg (Day 1), 100 mg (Day 2),
200 mg (Day 3) and 300 mg (Day 4).
Recommended dly dose is 300 mg.
May be titrated up to 600 mg dly. In
elderly or hepatic impairment:Start
with 50mg/ day, may be increased in
increments of 50mg /day to an
effective dose.

RM5.71/tab

200-400 mg bd; 800 mg dly in


predominantly negative symptoms and
2.4 g dly in mainly positive symptoms.
Elderly, lower initial dose; increased
gradually according to response. Child
< 14 yrs not recommended

RM0.13/tab

RM10.43/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
24 Amisulpride 100 mg
Tablet
(Solian)

25

Amisulpride 400 mg
Tablet
(Solian)

Cat Indications
A* Treatment of psychoses,
particularly acute or chronic
schizophrenia disorders
characterized by positive
symptoms(e.g. delusion,
hallucinations, thought
disorders) and/or negative
A* symptoms(e.g. blunted
emotions, emotional and
social withdrawal) including
when the negative
symptoms predominate

Dosage
Remark
Predominantly negative episodes: 50- RM1.38/tab
300 mg od adjusted according to the
KBUK
patient's response.
Mixed episodes with positive and
negative symptoms: 400-800 mg/day
in 2 divided doses adjusted according
to the patient's response.
RM5.17/tab
Should be taken on an empty stomach
(Preferably taken before meals)
KBUK

RM0.34/tab

26

Lithium Carbonate 300


mg Tablet

i) Prophylaxis and treatment


of acute mania and
hypomania episodes
ii)Prophylaxis of manic
depression in bipolar illness
or bipolar depression and
recurrent depression

1800 mg/day in 2-3 divided doses,


desired serum lithium level ranging
between 0.4-1 mmol/litre.
Maintenance 900-1200 mg/day in 2-3
divided doses

27

Risperidone 1 mg/ml Oral


Solution
(Risperdal)

Psychoses and
schizophrenia

28

Risperidone 1 mg Tablet
(Risperdal)

29

Risperidone 2 mg Tablet
(Risperdal)

ADULT: 2 mg in 1-2 divided doses on RM143.07/


1st day then 4 mg in 1-2 divided doses 30ml
on 2nd day then 6 mg in 1-2 divided
KBUK
doses on 3rd day (slower titration
appropriate in some patients); usual
RM0.07/tab
range 4-8 mg dly; dose > 10 mg dly
only if benefit outweighs risk (max: 16
mg dly). Elderly (or in hepatic or renal
impairment): initially 0.5 mg bd
increased in steps of 0.5 mg bd to 1-2 RM0.12/tab
mg bd. Not recommended in children
< 15 yrs

30

Risperidone Long acting


25mg Injection

A*

Treatment of acute and


chronic schizophrenic
psychosis and other
psychotic conditions, in
which positive and negative
symptoms are prominent. It
also alleviates affective
symptoms associated with
schizophrenia

25 mg IM every 2 wks. Dose


increments (if required) to 37.5 mg or
50 mg can be considered after a
minimum of 4 wks on each dosage

RM335.89/ea

i) Treatment of acute
episodes of schizophrenia
and for maintenance of
clinical improvement during
continuation therapy.
ii) Treatment of acute manic
episodes associated with
bipolar I disorder

Schizophrenia: 10 or 15 mg/day.
Maintenance dose: 15 mg/day. Bipolar
mania: Starting dose: 15 or 30
mg/day. Dose adjustment should
occur at intervals of not less than 24
hr

RM4.54/tab

Second or third line


treatment of schizophrenia

ADULT 6 mg once daily in the


morning, adjusted if necessary; usual
range 3 -12 mg daily. Renal
impairment (Clcr between 10-50
mL/min) 3 mg once daily. Avoid if Clcr
< 10mL/min

RM13.41/tab

(Risperdal Consta)

31

Aripiprazole 10mg Tablet

A*

32

Aripiprazole 15mg Tablet

A*

33

Paliperidone 3 mg
Extended Released
Tablet

A*

(Invega)

68

KBUK

RM6.26/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
34 Diazepam 5 mg Rectal
Solution

35

Diazepam 10 mg/2 ml
Injection

Cat Indications
C Status epilepticus, skeletal
muscle spasm

i) Status epilepticus
ii) Skeletal muscle spasm
iii) Anxiety disorders

i) Muscle spasm of varied


i) ADULT: 2-10 mg tds - qid. CHILD 6
aetiology, including tetanus mths and older: 0.12 - 0.8 mg/kg daily
ii) Anxiety disorders
in divided doses, every 6-8 hrs
ii) ADULT : 2 mg tds, increased in
severe anxiety to 15-30 mg dly in
divided doses. ELDERLY (or
delibitated) half adult dose. CHILD
(night terrors), 1-5 mg at bedtime

(Valium)

36

Diazepam 5 mg Tablet

Dosage
Remark
Status epilepticus - ADULT: 0.5 mg/kg RM30.58/ea
repeated after 12 hrs if necessary.
CHILD (febrile convulsions, prolonged
or recurrent): 0.5 mg/kg (max.10 mg),
repeated if necessary. Not
recommended for children < 2 yrs

(Valium)

i) Slow IV: 5-10 every 10-15 min (rate


< 5 mg/min), to a total dose of 30 mg,
may repeat in 2 hr if needed. Infants
30 days to 5 yrs, 0.05-0.3 mg/kg/dose
given over 2-3 min, every 15-30 min to
a total dose of 5 mg, repeat in 2-4 hrs
if necessary. CHILD > 5 yrs, 1 mg by
slow IV, every 2-5 min, max.10 mg,
repeat in 2-4 hrs if necessary
ii) Slow IV or IM, 5-10 mg repeated if
necessary in 3-4 hrs. CHILD (tetanus):
30 days - 5 years, 1-2 mg IM or IV
slowly every 3-4 hrs as needed. 5 yrs
and above, 5-10 mg IM or IV slowly
every 3-4 hrs if needed
iii) Anxiety disorders, 2-10 mg by slow
IV (< 5 mg/min). Repeat if necessary
every 3-4 hrs

RM1.45/amp

RM0.36/tab

RM0.20/tab
i) 1-4 mg increase to 10 mg dly in
divided doses. ELDERLY (or
delibitated) half adult dose
ii) 1-2 mg at bedtime Not
recommended in children
3-18 mg dly in divided doses. 6-30 mg RM0.33/tab
dly (single or divided doses) in anxietyneurosis. Children not recommended

37

Lorazepam 1 mg Tablet

A/KK i) Severe anxiety


ii) Insomnia

38

Bromazepam 1.5 mg
Tablet

Anxiety disorders

39

Clobazam 10 mg tablet

A*

As adjunctive therapy in
patients with epilepsy not
adequately stabilised with
their basic medication.

RM0.69/tab
The initial dose in adults and
adolescents >15 yr should be low (5
to15mg daily), if necessary, increased Borang E
gradually to a maximum daily dose of
about 80mg. Doses of up to 30mg
may be taken as a single dose in the
evening. The initial dose in children
from 3 to15 yr is normally 5mg. A
maintenance dose of 0.3 to 1.0mg/kg
daily is usually sufficient.

Anxiety disorders

0.25 - 0.5 mg tds (elderly or delibitated


0.25 mg bd - tds), increased if
necessary to a total dose of 3 mg/day.
Not recommended for children

(Frisium)

40

Alprazolam 0.5 mg Tablet


(Xanax)

41

Alprazolam 1 mg Tablet
(Xanax)

69

RM0.39/tab

RM0.75/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
42 Hydroxyzine HCl 25 mg
Tablet

Cat Indications
A Allergic pruritus

(Atarax)

Dosage
Remark
RM0.12/tab
Initially 25 mg on, increased if
necessary up to 25 mg tds - qid.
ADULT and CHILD > 10 yrs : 50-75
mg; 6-10 yrs: 25-50 mg; 1-5 yrs: 12.5 25 mg; to be taken dly in divided
doses
i) ADULT : For induction 200-400 mg. RM6.20/vial
For repeat injection 3-5 mg/kg over 10 15 secs until desired depth of
anaesthesia is obtained. Not FDA
approved for use in pediatric patients
ii) 75-125 mg IV single dose; for localanaesthetic induced convulsion: 125 250 mg IV over 10 min

43

Thiopental Sodium 500


mg Injection

i) General anaesthesia,
induction
ii) Anticonvulsant for cases
resistant to conventional
anticonvulsants in the ICU

44

Chloral Hydrate 200 mg/5


ml Mixture

Preoperative sedation

ADULT : 0.5 -1 g (max 2 g) with plenty


of water at bedtime. CHILD : 30-50
mg/kg up to a max dose of 1 g

RM177.4/
500gm

45

Midazolam 5 mg/ml
Injection

Pre-operative sedation,
induction of general
anaesthesia, premedication
and sedation in ICU and
sedation for minor
procedures

Usual sedative range 2.5 - 7.5 mg


(about 70 mcg/kg by IV injection over
30 seconds). Premedication by IM
injection 70 - 100 mcg/kg 30 -60
minutes before surgery; ELDERLY: 1 1.5 mg/kg. Induction: Induction by
slow IV infusion 200 - 300 mcg/kg
(ELDERLY 100 - 200 mcg/kg. CHILD
over 7 years 150 - 200 mcg/kg);
Maximum: 0.35mg/kg. Sedation in ICU
0.03 - 0.2 mg/kg/hour

RM1.03/amp

ADULT: Usually 7.5 - 15 mg at


bedtime; or for premedication, 30-60
min before the procedure. For
ELDERLY, debilitated or impaired
liver/kidney function: 7.5 mg

RM1.10/tab

(Dormicum)

46

Midazolam 7.5 mg Tablet A/KK Pre and post-operative


sedation
(Dormicum)

N06 Psychoanaleptics
No Generic Name
1 Imipramine HCl 25 mg
Tablet

Cat Indications
B Depression

Clomipramine HCl 25 mg
Tablet

Depressive illness,
obsessive-compulsive
disorder

Amitriptyline HCl 10 mg
Tablet

Depression

Amitriptyline HCl 25 mg
Tablet

Dosage
Remark
RM0.05/tab
Initially up to 75 mg dly in divided
doses increased gradually to 150 200 mg (up to 300 mg in hospital
patients); up to 150 mg may be given
as a single dose at bedtime.
ELDERLY initially 10 mg dly;
increased gradually to 30-50 mg daily;
CHILD is not recommended
Initially 10 mg dly, increased gradually RM0.34/tab
as necessary to 30-150 mg dly in
divided doses or as a single dose at
bedtime; max 250 mg dly. ELDERLY
initially 10 mg dly increased carefully
over approximately 10 days to 30-75
mg dly; CHILD not recommended
Initially 75 mg. ADULT and ELDERLY
: 30-75 mg dly in divided doses or as a
single dose at bedtime, increase
gradually as necessary to 150-200
mg. CHILD < 16 yrs are not
recommended

70

RM0.11/tab

RM0.15/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
5 Dothiepin HCl 25 mg
Capsule
6

Dothiepin HCl 75 mg
Tablet

Fluoxetine HCL 20 mg
Capsule
(Prozac)

Sertraline HCL 50 mg
Tablet

Cat Indications
Dosage
Remark
A Depression of any aetiology Initially 75 mg (ELDERLY 50-75 mg) RM0.27/cap
dly in divided doses or single dose at
bedtime, increased gradually as
necessary to 150 mg dly (ELDERLY
RM0.34/tab
A
75 mg may be sufficient), up to 225
mg dly in some circumstances. CHILD
is not recommended
RM0.20/cap
A i) Depressive illness
i) 20 mg od increased after 3 wks if
ii) Obsessive-compulsive
necessary, usual dose 20-60 mg
disorder
(ELDERLY 20-40 mg) od, max 80 mg
od (ELDERLY max 60 mg od).
ii) Initially 20 mg od increased after 2
wks if necessary, usual dose 20-60
mg (ELDERLY 20-40 mg) od, max 80
mg (ELDERLY max 60 mg) od,
discontinue if no improvement within
10 wks. CHILD < 18 yrs are not
recommended
B

Major depression, obsessive-Depression, obsessive-compulsive


compulsive disorder (OCD), disorder: 50 mg/day. Panic disorder:
panic disorder
Initially 25 mg/day. After 1 wk,
increase dose to 50 mg/day. All dose
changes should be made at intervals
of more than 1 wk, max: 200 mg/day

RM0.18/tab

Depressive disorder

RM0.54/tab

(Zoloft)

For depression, initially 50-100 mg


daily in the evening, increased if
necessary to 300 mg dly (over 150 mg
in divided doses); usual maintenance
dose 100 mg dly. CHILD < 18 yrs not
recommended

Fluvoxamine 50 mg
Tablet
(Luvox)

10

Fluvoxamine 100 mg
Tablet
(Luvox)

11

Escitalopram 10mg
Tablet

A*

i) Treatment of major
depressive episodes
ii) Treatment of panic
disorder with or without
agoraphobia

i) 10 mg od; may be increased to max RM1.79/tab


20 mg dly.
ii) Panic disorder with or without
KBUK
agoraphobia :Initially 5 mg for the first
wk, thereafter increased to 10 mg dly.
May be further increased up to max 20
mg dly, dependent on individual
patient response. ELDERLY initially
half adult dose, lower maintenance
dose may be sufficient. CHILD < 18
yrs not recommended

A*

Treatment of depressive
syndrome

Initially 300 mg dly in divided doses.


Gradually to increase up to 600 mg dly
in divided doses depending on
response. Usual range 150-600 mg
dly. Not recommended in children

A*

Episodes of major
depression

Initially 15 mg dly at bedtime


RM4.18/tab
increased according to response up to KBUK
45 mg dly as a single dose at bedtime
or in 2 divided doses. CHILD < 18 yrs
not recommended

A*

i) Depression
ii) Generalized anxiety
disorder
iii) Social anxiety disorder
(social phobia)
iv) Panic disorder

i), ii) & iii) ADULT: 75 mg od. May


increase dose by 75 mg/day every 4
days to a max. 225 mg/day
iv) 37.5 mg/day for the first 4-7 days
after which the dose should be
increased to 75 mg od. CHILD < 18
yrs not recommended

(Lexapro)

12

Moclobemide 150 mg
Tablet
(Aurorix)

13

Mirtazapine 30mg
Orodispersible Tablet
(Remeron)

14

Venlafaxine HCl 75 mg
Extended Release
Capsule
(Efexor XR)

71

RM1.08/tab

RM2.41/tab

RM3.66/tab

KBUK

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
16 Methylphenidate HCl 10
mg Tablet

Cat Indications
A Hyperkinetic disorder
(attention deficit
hyperactivity disorder)

(Ritalin)

17

Methylphenidate HCL
18mg Extended-release
Tablet

A*

(Concerta)

18

Piracetam 1.2 g Tablet

A*

(Nootropil)

19

Donepezil HCl 5 mg
Tablet

(Aricept)

20

Rivastigmine 3 mg
Capsule

Rivastigmine 9.5 mg/24hr


Transdermal Patch

Memantine HCI 10 mg
Tablet
(Ebixa)

CHILD > 6 yrs: od to be taken in the


RM5.19/tab
morning. Dose may be adjusted in
increments to a max. of 54 mg/day, at Borang E
wkly interval. Patient new to
methylphenidate: starting dose 18 mg
od. Patient currently using
methylphenidate: 18-36 mg. Max. 54
mg/day. Discontinue if no response
after 1 mth
Mild cognitive impairment, Initially 7.2 g dly in 2-3 divided doses, RM0.67/tab
post concussional head
increased according to response by
syndrome, head injury
4.8 g dly every 3-4 days to max.of 20
disorder, chronic vertigo and g dly. CHILD < 16 yrs not
myoclonus
recommended
Treatment of mild to
5 - 10 mg od at bedtime. Max 10 mg
moderate dementia in
dly
Alzheimer's disease, as well
as in patients with severe
Alzheimer's disease.

RM3.30/tab

KBUK

For psychiatrists and


neurologists only. Mild to
moderately severe dementia
associated with Alzheimer's
or Parkinson's disease

Initial dose 1.5 mg bd, may increase


RM3.83/cap
by 1.5 mg bd every 2 wks to max of 6
KBUK
mg bd. If treatment is interrupted for
several days, should be reinitiated at
the lowest dly dose

A*

Mild to moderately severe


dementia associated with
Alzheimer's or Parkinson's
disease

Initial, 4.6 mg/24 hr patch TOPICALLY RM8.74/ea


once daily; after a minimum of 4
weeks and good tolerability, increase KBUK
the dose to 9.5 mg/24 hour patch once
daily

A*

As monotherapy or as
adjunctive therapy with
cholinesterase inhibitors for
the symptomatic treatment
of patients with moderate to
severe Alzheimer?s
disease.

Adult Initially 5 mg/day on the 1st


week, 5mg bd on the 2nd week, then
15 mg/day (10mg in the morning and
5mg in the evening) on the 3rd week.
From the 4th week on, continue
treatment with maintenance dose of
20 mg/day (10mg bd). Max: 20
mg/day.

(Exelonpatch 10)
22

Attention deficit
hyperactivity disorder
(ADHD)

A*

(Exelon)

21

Dosage
Remark
RM1.71/tab
CHILD > 6 yrs, initially 5 mg od - bd,
increased if necessary at wkly
intervals by 5-10 mg dly to max. 60 mg
dly in divided doses; discontinue if no
response after 1 mth, also suspend
periodically to assess child's condition
(usually finally discontinued during or
after puberty)

72

RM5.71/tab

Borang E

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

N07 Other Nervous System Drugs


No Generic Name
Cat
1 Neostigmine
B
Methylsulphate 2.5 mg/ml
Injection

Pyridostigmine Bromide
60 mg Tablet

Indications
i) Myasthenia gravis
ii) Reversal of nondepolarising neuromuscular
blockade

Dosage
Remark
RM0.92/amp
i) ADULT: 1 - 2.5 mg at suitable
intervals by SC, IM or IV. Usual total
dly dose 5-20 mg. CHILD: 200-500
mcg at suitable intervals throughout
the day. NEONATE: 50-250 mcg every
4 hrs ii) By IV injection over 1 min, 5070 mcg/kg (max 5 mg) after or with
atropine sulphate 0.6-1.2 mg

Myasthenia gravis

ADULT: 30-120 mg at suitable


intervals throughout the day, total daily
dose 0.3 - 1.2 g. CHILD up to 6 yrs
initially 30 mg, 6-12 yrs initially 60 mg,
usual total dly dose 30-360mg

(Mestinon)

RM0.19/tab

Betahistine Mesylate 6
mg Tablet

Betahistine
Dihydrochloride 24 mg
Tablet (Betaserc)

A*

Vertigo, tinnitus and hearing 24 mg bd


loss associated with
Meniere's disease

RM1.04/tab

Cinnarizine 25 mg Tablet
(Stugeron)
Flunarizine HCl 5 mg
Capsule

Vestibular disorders

1 tablet tds

RM0.05/tab

i) Migraine prophylaxis
ii) Maintenance treatment of
vestibular disturbances and
of cerebral and peripheral
disorders

i) ADULT: 5-10 mg dly preferably at


night. ELDERLY > 65 yrs: 5 mg on.
Maintenance 5-day treatment at the
same daily dose
ii) 5-10 mg on. If no improvement after
1 mth, discontinue treatment

RM0.20/cap

(Sibelium)

A/KK Vertigo, tinnitus and hearing Given in doses of 8-16 mg orally tds
loss associated with
(total 24-48 mg/day) preferably with
Meniere's disease
food. CHILD not recommended

RM0.54/tab

73

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS

P01 Antiprotozoals
No Generic Name
1 Metronidazole 200 mg
Tablet

Cat Indications
B Anaerobic infection

Dosage
800 mg initially followed by 400 mg
tds. CHILD: 7.5 mg/kg tds

Remark
RM0.06/tab

Chloroquine Phosphate
250 mg Tablet (150 mg
Chloroquine base)

Treatment of malaria - acute ADULT 600 mg base stat, 300 mg 6 attack


8 hrs later and a further 300 mg on
each of 2 following days. CHILD 3-4
yrs : 150 mg base stat, 75 mg 6 hrs
later, then 75 mg dly for 2 days.
CHILD 5-8 yrs : 300 mg stat, 150 mg 6
hrs later, then 150 mg dly for 2 days

RM0.12/tab

Hydroxychloroquine
Sulphate 200 mg Tablet

i) SLE and mixed


connective tissue disease
for skin, joint and serosa
ii) Second line therapy for
acute rheumatoid arthritis

i) Initially 400 mg dly in divided dose.


Maintenance : 200-400 mg dly
ii) ADULT : 400-600 mg dly.
Maintenance: 200-400 mg dly.
CHILD : up to 6.5 mg/kg dly (max.
400mg dly)

RM1.76/tab

Primaquine 7.5 mg base


Tablet

i) Treatment of malaria
ii) Prophylaxis together with
a schizonticide such as
chloroquine

i) ADULT: 15 mg dly for 14 days.


CHILD: 0.3 mg/kg dly for 14 days
ii) ADULT: 30 mg once wkly.
CHILD: 0.5 mg once wkly

RM0.96/tab

Quinine Dihydrochloride
600 mg/2 ml Injection

Suppression or treatment of
chloroquine-resistant
Plasmodium Falciparum
malaria in conjunction with
other antimalarial agents

RM19.67/amp
By slow IV infusion (over 4 hrs).
ADULT : 20 mg/kg followed by 10
mg/kg tds. CHILD : 20 mg/kg followed Borang E
by 10 mg/kg every 12 hrs, initial dose
should be half in patients who have
received quinine, quinidine or
mefloquine during the previous 12 or
24 hrs

Quinine Sulphate 300mg


Tab

Suppression or treatment of
chloroquine-resistant
Plasmodium Falciparum
malaria in conjunction with
other antimalarial agents

300-600 mg dly. Treatment : 1.2 - 2 g


daily in divided doses. CHILD < 1 yr:
100-200 mg dly, 1-3 yrs: 200-300 mg
daily, 4-6 yrs: up to 500 mg dly, > 7 yrs
: up to 1 g dly. All above doses are
given for 7 days in 2-3 divided doses

RM0.21/tab

Sulfadoxine 500 mg &


Pyrimethamine 25 mg
Tablet

Treatment of Plasmodium
falciparum malaria in
patients in whom
chloroquine resistance is
suspected and malaria
prophylaxis for travellers to
areas where chloroquineresistant malaria is endemic

Treatment as single dose. ADULT: 2 3 tablet. CHILD > 45 kg: 3 tablets, 45


to 31 kg : 2 tablets, 30 to 21 kg : 1 and
half tablets, 20 to 11 kg : 1 tablet, 5 to
10 kg : one-half tablet

RM0.18/tab

A*

Acute uncomplicated
falciparum malaria

ADULT and CHILD >12 yrs, > 35 kg: 4 RM2.58/tab


tablets as a single dose at the time of
initial diagnosis, again 4 tablets after 8 Borang E
hrs and then 4 tablets bd (morning and
evening) on each of the following two
days (total course comprises 24
tablets).
INFANT and CHILD 5-35kg: A 6 dose
regimen with 1 to 3 tablets per dose,
depending on bodyweight

(Fansidar)

Artemether 20mg +
Lumefantrine 120mg
(Riamet)

74

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
9 Pyrimethamine 25 mg
Tablet

P02 Antihelmintics
No Generic Name
1 Diethylcarbamazine
Citrate 50 mg Tablet
(DEC)

Cat Indications
Toxoplasmosis (is used
conjointly with a
sulfonamide, since
synergism exists with this
combination)

Dosage
Remark
RM2.94/tab
ADULT starting dose is 50 to 75 mg
daily, together with 1 to 4 g daily of a
KPK
sulfonamide of the sulfapyrimidine
type, e.g., sulfadoxine. This dosage is
ordinarily continued for 1 to 3 weeks,
depending on the response of the
patient and tolerance to therapy. The
dosage may then be reduced to about
one half that previously given for each
drug and continued for an additional 4 5 weeks.
CHILD: 1 mg/kg/day divided into 2
equal daily doses; after 2 to 4 days
this dose may be reduced to one half
and continued for approximately 1
month.

Cat Indications
B i) Bancrofti filariasis,
onchocerciasis, loasis,
creeping eruption
ii) Ascariasis
iii) Tropical eosinophilia

Dosage
Remark
RM0.09/tab
i) 1 mg/kg on the first day and
increased gradually over 3 days to 6
Borang E
mg/kg daily in divided doses. This
dosage is maintained for 21 days.
ii) 13 mg/kg once daily for 7 days.
CHILD : 6 - 10 mg/kg tds for 7 days iii)
6 mg/kg/day in 3 divided doses for 21
days

Albendazole 200 mg/5 ml


Suspension (Zentel)

Albendazole 200 mg
Tablet (Zentel)

i) Single or mixed
infestations of intestinal
parasites
ii) Strongyloides infection

i) ADULT and CHILD > 2 yrs : 400 mg


as a single dose
ii) 400 mg as a single dose for 3
consecutive days. CHILD 12-24 mths:
half adult dose

RM3.88/10ml

RM0.34/tab

P03 Ectoparasiticides, Incl. Scabicides, Insecticides and Repellents


No Generic Name
1 Crotamiton 10 % Cream
(Eurax)

Cat Indications
A/KK i) Pruritus
ii) Scabies
iii) Insect bite reactions

Dosage
Remark
i) and iii) Massage into affected area RM2.80 /
15gm
until the medication is completely
absorbed. Repeat as needed. Apply
bd or tds
ii) Apply topically (do not rinse off),
apply a 2nd time and leave on skin for
24-48 hrs. For resistant scabies,
treatment (2 applications at 24 hr
interval) may be repeated after 1 wk

Gamma Benzene
Hexachloride 0.1 %
Lotion (Lindane)

Scabies

Apply lotion to entire body from neck


down for 8 to 12 hrs, then rinse

Benzyl Benzoate 12.5%


Emulsion (child)

Benzyl Benzoate 25%


Emulsion (Adult)

Scabies and pediculosis, for After bath, apply over the whole body,
child < 2 yrs
neck down and leave on for 24 hrs
then wash off. Reapply for another 24
hrs, the first repeat application should
be within 5 days of the initial
Scabies and pediculosis
application, a third application may be
required in some cases

75

RM18.28/L

RM0.94/
120ml

RM1.89/
120ml

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

RESPIRATORY SYSTEM

R01 Nasal Preparations


No Generic Name
1 Ephedrine 0.5% w/v
Nasal Drops

Cat Indications
A/KK Decongestion of the upper
respiratory tract

Dosage
2 drops tds. Max. use for 1 wk

Remark
RM0.50/ea

Oxymetazoline HCl
0.025% (Paed) Nasal
Spray

Acute colds, paranasal


sinusitis and otitis media

2 - 3 sprays into each nostril bd for


child > 1 yr

RM8.25/15ml

Oxymetazoline HCl
0.05% (Adult) Nasal
Spray

Acute colds, paranasal


sinusitis and otitis media

2 - 3 sprays into each nostril bd, max.


6 sprays per nostril/day

RM8.75/15ml

Beclomethasone
Dipropionate 50
mcg/dose Nasal Spray

ADULT and CHILD > 6 yrs : Apply 100


mcg (2 sprays) into each nostril bd or
50 mcg (1 spray) into each nostril 3 - 4
times/day. Max.400 mcg dly (8
sprays). When symptoms controlled,
reduce dose to 50 mcg (1 spray) into
each nostril bd

RM12.00/ea

A/KK Prophylaxis and treatment


of perennial and seasonal
allergic rhinitis and
vasomotor rhinitis

(Beconase)

Budesonide 50 mcg/dose
Nasal Spray
(Rhinocort )

Seasonal allergic, perennial ADULT and CHILD 6 yrs and older.


rhinitis and nasal polyposis Rhinitis : 2 spray into each nostril om
or 1 spray into each nostril bd.
Nasal polyps : 2 spray bd

RM16.20/ea

Mometasone Furoate 50
mcg Aqueous Nasal
Spray

A*

Allergic rhinitis

ADULT and CHILD > 12 yrs: 100


mcg/day (2 sprays) to each nostril od.
Max.200 mcg (4 sprays) od. Reduce
to 50 mcg (1 spray) od when control
achieved. CHILD 6-12 yrs: 50 mcg (1
spray) to each nostril od

RM27.37/ea

As directed for local use

RM170.40/kg

(Nasonex)
7

Menthol 1.6% in Ind.


Methylated Spirit
Inhalation

Decongestion of the upper


respiratory tract

Bismuth Subnitrate,
Iodoform & Liquid
Paraffin Paste

As a mild antiseptic for


As directed for local application
wounds and abscesses.
Sterile gauze impregnated
with paste for packing
cavities after otorhinological
surgery

RM0.37/gm

Decongestion of the upper


respiratory tract in common
cold, hay fever, allergic and
vasomotor rhinitis and
sinusitis

ADULT and CHILD > 12 yr: 10 ml.


CHILD 6-12 yr: 5 ml, 2-5 yr: 2.5 ml, 6
mths -2 yr: 1.25 ml. Doses to be taken
bd or tds. Not FDA approved in
children < 6 yrs

RM20.80/60ml

ADULT and CHILD > 12 yrs: 1 tablet


bd

RM1.12/tab

(BIPP)
9

Triprolidine HCl 1.25 mg


& Pseudoephedrine HCl
30 mg per 5 ml Syrup
(Actifed)

10

Loratadine 5 mg &
Pseudoephedrine
Sulphate 120 mg Tablet
(Clarinase)

R02 Throat Preparations


No Generic Name
1 Chlorhexidine Gluconate
0.2 % Mouthwash
2

Fusafungine 1% Nasal
Spray
(Locabiotal)

A/KK For treatment of allergic


rhinitis and allergic
dermatoses

Cat Indications
C As a gargle
A

Dosage
Rinse mouth with 10 ml for about 1
min bd

Local antibiotic, antiinflammatory treatment of


infectious and inflammatory
syndromes of the respiratory
mucosa

76

ADULT : 1 oral or 1 nasal inhalation 4


hrly, withdraw if no improvement after
7 days. CHILD : 1 oral or 1 nasal
inhalation 6 hrly, withdraw if no
improvement after 7 days

Remark
RM0.50

RM45.75/ea

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

R03 Drugs for Obstructive Airway Diseases


No Generic Name
Cat Indications
1 Salbutamol 100
B Asthma and other
mcg/dose Inhalation
conditions associated with
(Ventolin)
reversible airways
obstruction

Dosage
Remark
ADULT : 100-200 mcg up to tds - qid. RM7.51/ea
CHILD : 100 mcg increased to 200
mcg if necessary

Salbutamol 0.5 %
Inhalation Solution
(Ventolin)

Asthma and other


conditions associated with
reversible airways
obstruction

2 ml may be inhaled up to qid over a


period of 3 min per inhalation (0.5 ml
diluted in 2.5 ml of normal saline by
inhalation over 5-15 min)

RM4.18/10ml

Terbutaline Sulphate 10
mg/ml Inhalation Solution
(Bricanyl)

Asthma and other


conditions associated with
reversible airways
obstruction

ADULT : 5-10 mg bd - qid, additional


doses may be necessary in severe
acute asthma. CHILD up to 3 yrs : 2
mg, 3-6 yrs: 3 mg, 6-8 yrs: 4 mg, > 8
yrs : 5 mg bd - qid

RM28.88/
50ml

Ipratropium Bromide 20
mcg and Fenoterol 50
mcg/dose Inhalation

Management of symptoms
in chronic obstructive
airway disorders with
reversible bronchospasm
such as bronchial asthma
and chronic bronchitis with
or without emphysema

ADULT & CHILD >6 yrs; Acute asthma


2 puffs. Severe cases: if breathing has
not noticebly improved after 5 mins, 2
further puffs may be taken. Intermitent
and long-term treatment: 1-2 puffs for
each administration, up to max 8
puffs/day (average: 1-2 puffs tds)

RM15.20/ea

Management of reversible
bronchospasm associated
with obstructive airway
diseases

Acute attacks : 1 unit dose vial. In


severe cases not relieved by 1 unit
dose vial, 2 unit dose vials may
require, patient should consult a
doctor immediately. Maintenance : 1
unit dose vial tds - qid

RM0.85/ea

A/KK Regular treatment of


reversible obstructive
airways diseases including
asthma

ADULT and CHILD >12 yrs: 1-2 puff


bd. CHILD > 4 yrs : 1 puff bd

RM49.25/ea

(Berodual)

Ipratropium Bromide 0.5


mg & Salbutamol 2.5 mg
per UDV
(Duolin/ Combivent)

Salmeterol 50 mcg &


Fluticasone Propionate
250 mcg Inhalation
(Seretide Accuhaler)
Salmeterol 25mcg +
Fluticasone 125mg
Evohaler 120 Dose
(Seretide Evohaler)

A*

Budesonide 320 mcg and


Formoterol 4.5 mcg
Inhalation (Symbicort)

A*

Budesonide 160 mcg and


Formoterol 4.5 mcg
Inhalation (Symbicort)

10

Beclomethasone
Dipropionate 100
mcg/dose Inhalation

11

Budesonide 200
mcg/dose Inhalation

12

Budesonide 500 mcg/2


ml Nebulising Solution

KBUK

Regular treatment of
reversible obstructive
airways diseases including
asthma

ADULT and CHILD >12 yrs: 1-2 puff


bd. CHILD > 4 yrs : 1 puff bd

i) Regular treatment of
asthma where use of a
combination (inhaled
corticosteroid & long-acting
2-agonist) is appropriate.
ii) Symptomatic treatment of
patients with severe COPD
(FEV1

Asthma; Maintenance therapy: Adult RM88.00/ea


18 yr 160 mcg to 320 mcg bd. Some
KBUK
patients may require up to a max of
640 mcg bd. Adolescent 12-17 yr 160
mcg to 320 mcg bd. Childn 6-11 yr
RM103.4/ea
160 mcg bd,
KBUK

Prophylaxis of asthma
especially if not fully
controlled by
bronchodilators
Maintenance treatment of
asthma as prophylactic
therapy especially if not fully
controlled by
bronchodilators
Maintenance treatment of
asthma as prophylactic
therapy especially if not fully
controlled by
bronchodilators

ADULT : 100 mcg tds - qid or 200 mcg


bd. CHILD > 6 yrs : 50-100 mcg bd qid

RM14.51/ea

ADULT : 200-1600 mcg dly in 2-4


divided doses. Maintenance with bd
dosing. CHILD >7 yrs 200-800 mcg, 27 yrs 200-400 mcg. To be taken orally
in 2-4 divided doses
ADULT : Initially 1-2 mg bd. CHILD 3
mths -12 yrs: 500 mcg-1 mg.
Maintenance dose : half of the above
doses

RM27.26/ea

77

RM78.30/ea

KBUK

RM4.28/ea

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
13 Fluticasone Propionate
125 mcg/dose Inhalation

Cat Indications
B Prophylactic treatment for
asthma

(Flixotide)

14

Ipratropium Bromide 20
mcg/dose Inhalation

(Atrovent)

15

Ipratropium Bromide
0.025 % Inhalation Soln
(250 mcg/ml)

(Atrovent)

16

Tiotropium bromide
Inhalation 18 mcg
Capsules & Handihaler
(Spiriva)

Dosage
Remark
RM27.37/ea
ADULT and CHILD >12 yrs
i) Mild asthma : 100-250 mcg bd
ii) Moderate asthma: 250-500 mcg bd
iii) Severe asthma: 500-1000 mcg bd.
Alternatively, the starting dose of
fluticasone dipropionate may be
gauged at half the total dly dose of
beclomethasone dipropionate or
equivalent administered by inhalation.
CHILD 4-11 yrs, 50 mcg bd
(max: 100 mcg bd)
RM11.86/ea
20-40 mcg tds - qid. In the early
treatment, up to 80 mcg tds - qid.
CHILD up to 6 yrs : 20 mcg tds,
6-12 yrs : 20-40 mcg tds

Only for treatment of : i)


Patients with chronic
bronchitis who have airway
obstruction and who do not
respond to Salbutamol or
Terbutaline ii) Patients with
ischaemic heart disease
who develop extrasystole
with Salbutamol or
Terbutaline
Only for treatment of : i)
ADULT : 500 mcg up to qid.
Patients with ischaemic
CHILD 5-12 yrs: 125-250 mcg up to
heart disease who develop qid, 12 yrs : 250-500 mcg up to qid
extrasystole with salbutamol
or terbutaline ii) Patients
with chronic bronchitis who
have airway obstruction and
who do not respond to
salbutamol or terbutaline.
Reversible airways
obstruction, particularly in
chronic obstructive
pulmonary disease

A/KK Long term maintenance


treatment of bronchospasm
and dypsnoea associated
with COPD. Tiotropium has
usually been added to
standard therapy (e.g.
inhaled steroids,
theophylline, albuterol
rescue)

RM1.15/ea

1 capsule od.
RM3.74/cap
Inhale the contents of capsule with the
handihaler device at the same time of KBUK
day.
Child and adolescent < 18 years, not
recommended

17

Ephedrine HCl 30 mg/ml


Injection

Treatment of bronchial
spasm in asthma, adjunct to
correct haemodynamic
imbalances and treat
hypotension in epidural and
spinal anaesthesia

By IM, SC or IV. Severe, acute


bronchospasm : 12.5-25 mg.
When used as a pressor agent :
ADULT 25-50 mg SC/IM. If necessary,
a 2nd IM dose of 50 mg or an IV dose
of 25 mg may be given. Direct IV
injection, 10-25 mg may be given
slowly. Max. parenteral ADULT dose:
150 mg in 24 hrs. CHILD : 3 mg/kg or
100 mg/m2 SC or IV dly, in 4-6 divided
doses

RM1.03/amp

18

Salbutamol 2 mg/5 ml
Syrup
(Ventolin)

Asthma and other


conditions associated with
reversible airways
obstruction

CHILD 2-6 yrs: 1-2 mg tds - qid,


6-12 yrs: 2 mg tds - qid

RM1.15/60ml

78

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
19 Salbutamol 0.5 mg/ml
Injection
(Ventolin)

Cat Indications
A Asthma and other
conditions associated with
reversible airways
obstruction

20

A*

Prevention of uncomplicated Infusions containing 5 mg in 500ml (10


premature labour only
mcg/ml) at the rate of 10-45 mcg/min
increased at intervals of 10 min until
evidence of patient response as
shown by reduction of strength,
frequency or duration of contractions;
maintain rate for 1 hr after contractions
have stopped, then gradually reduce
by 50% every 6 hrs

RM39.65/amp

Asthma and other


conditions associated with
reversible airways
obstruction

CHILD 2-6 yrs: 1-2 mg tds - qid,


6-12 yrs: 2 mg tds - qid.
CHILD >12 yrs and ADULT : 2-4 mg
tds - qid

RM0.015/tab

Bronchial asthma, chronic


bronchitis, emphysema and
other lung diseases where
broncoconstriction is a
complicating factor

SC, IM or slow IV : 250-500 mcg up to


qid. CHILD 2-15 yrs 10mcg/kg to a
max. of 300 mcg. Continuous IV
infusion, as a solution containing 3 - 5
mcg/ml, 1.5 -5 mcg/min for 8-10 hrs;
reduce dose for children
ADULT: 125 mg tds - qid after food,
increased to 250 mg if required.
CHILD: 1-15 yrs : 5 mg/kg/dose (up to
600 mg/ day) tds - qid

RM3.25/amp

Salbutamol 5 mg/5 ml
Injection
(Ventolin)

21

Salbutamol 2 mg Tablet
(Ventolin)

22

Terbutaline Sulphate 0.5


mg/ml Injection
(Bricanyl)

Dosage
Remark
500 mcg by SC/IM injection 4 hrly or RM1.66/amp
250 mcg by slow IV. If required, by IV
infusion, initially 5 mcg/min adjusted
according to response and heart rate,
usually in the range 3-20 mcg/min

RM0.02/tab

23

Theophylline 125 mg
Tablet
(Neulin)

Reversible airways
obstruction, acute severe
asthma

24

Theophylline 250 mg
Long Acting Tablet
(Neulin SR)

Reversible airways
obstruction and acute
severe asthma

ADULT: 250 mg bd. CHILD < 12 yrs:


Up to 10 mg/kg bd

RM0.16/tab

25

Aminophylline 25 mg / ml
Injection

Reversible airways
obstruction, acute severe
asthma

Deteriorating acute asthma not


previously treated with theophylline, by
slow IV injection over 20 min 250 - 500
mg (5 mg/kg), then as for acute severe
asthma.
Acute severe asthma by IV infusion :
500 mcg/kg/hr, adjusted according to
plasma-theophylline concentration.
CHILD : 6 mth-9 yrs: 1 mg/kg/hr,
10-16 yrs: 800 mcg/kg/hr

RM4.40/amp

26

Montelukast Sodium 4
mg Oral Granules
(Singulair)

A*

12 mths - 5 yrs: 1 packet of 4mg oral


granules dly at bedtime

RM3.98/ea

Montelukast Sodium 5
mg Chewable Tablet
(Singulair)

A*

Asthmatics, not controlled


on high dose inhaled
corticosteroids > 1600
mcg/day and with co-morbid
allergic disorders. Chronic
treatment of asthma

Montelukast Sodium 10
mg Tablet
(Singulair)

A*

27

28

KBUK
CHILD 6-14 yrs: One 5 mg chewable
tablet dly at bedtime

Chronic treatment of asthma CHILD > 15 yrs and ADULT: 10 mg


and relief of symptoms of
dly at bedtime
seasonal allergic rhinitis for
children > 15 yrs and adults

79

RM0.96/tab

KBUK
RM0.96/tab

KBUK

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

R05 Cough and Cold Preparations


No Generic Name
Cat Indications
1 Bromhexine HCl 4 mg/5
B Secretolytic therapy in acute
ml Elixir
and chronic
bronchopulmonary diseases
2 Bromhexine HCl 4 mg/2
A associated with abnormal
ml Injection
mucous secretion and
3 Bromhexine HCl 8 mg
B impaired mucous transport
Tablet (Bisolvon)
R06 Antihistamines for Systemic Use
No Generic Name
Cat Indications
1 Diphenhydramine HCl
C Cough
14mg/5ml & Ammonium
Chloride 135mg/5ml
Expectorant (Benadryl)
2 Dexchlorpheniramine
B Symptomatic treatment of
Maleate 2 mg/5 ml Syrup
allergic rhinitis

Dosage
Remark
ADULT & CHILD > 12 yrs: 10 ml tds, 6- RM0.92/60ml
12 yrs : 5 ml tds, 2-6 yrs: 2.5 ml tds, <
2 yrs: 1.25 ml tds
RM0.92/amp
4 mg SC, IM or IV bd - tds
ADULT & CHILD > 12 yrs: 8 mg tds, 612 yrs: 4 mg tds, 2-6 yrs: 4 mg bd

Dosage
ADULT : 5 - 10 ml bd - tds.
CHILD : 2.5 - 5 ml bd - tds.

RM0.02/tab

Remark
RM3.36/90ml

CHILD 2-5 yrs : 0.5 mg every 4-6 hrs;


6-11 yrs : 1 mg every 4-6 hrs

RM1.30/60ml

ADULT : 2 mg tds.
CHILD 1-12 yrs : 2 mg tds

RM0.02/tab

Dexchlorpheniramine
Maleate 2 mg Tablet
(Polaramine)

Symptomatic treatment of
allergic rhinitis and allergic
dermatoses

Chlorpheniramine
Maleate 2 mg/5ml Syrup
(Piriton)

Symptomatic treatment of
CHILD 1-2 years : 1 mg bd, 2-5 yrs : 1
allergic conditions
mg every 4-6 hrs (max 6 mg dly), 6-12
responsive to antihistamine yrs : 2 mg every 4-6 hrs (max 12 mg
dly)

RM3.01/ 60ml

Chlorpheniramine
Maleate 10 mg/ml
Injection

Allergic conditions

RM0.27/amp

Chlorpheniramine
Maleate 4 mg Tablet
(Piriton)

Symptomatic treatment of
ADULT : 4 mg every 4-6 hrs. Max 24
allergic conditions
mg dly. CHILD 1-2 yrs : 1 mg bd, 2-5
responsive to antihistamines yrs: 1 mg every 4-6 hrs (max. 6 mg
dly), 6-12 yrs: 2 mg every 4-6 hrs
(max. 12 mg dly)

RM0.03/tab

Promethazine HCl 5 mg/5


ml Syrup (Phenergan)

Allergic conditions

CHILD 2-5 yrs: 5-15 mg dly,


5-10 yrs : 10-25 mg dly

RM3.01/60ml

Promethazine HCl 25
mg/ml Injection

Allergic conditions

By deep IM: ADULT: 25-50 mg, max.


100 mg. CHILD: 5-10 yrs: 6.25 - 12.5
mg. By slow IV: 25 - 50 mg in a
solution of 2.5 mg/ml in water for
injection. Max 100 mg

RM2.90/amp

Cetirizine HCl 10 mg
Tablet
(Zyrtec)

A/KK Urticaria, allergic


dermatoses (insect bites,
atopic eczema), perennial
rhinitis, allergic rhinitis

ADULT and CHILD > 6 yrs:10 mg dly


or 5 mg bd. Child 2-6 yrs: 5 mg od or
2.5 mg bd

RM0.05/tab

10

Loratadine 1 mg/ml Syrup


(Clarityne)

ADULT and CHILD >6 yrs: 10 mg od.


CHILD 2-6 yrs: 5 mg od

RM1.67/60ml

11

Loratadine 10 mg Tablet
(Clarityne)

Allergic rhinitis, chronic


urticaria and other allergic
dermatological disorders

Desloratadine 5 mg
Tablet
(Aerius)

A*

Allergic rhinitis and chronic


idiopathic urticaria

ADULT & CHILD more than 12 years :


5 mg once daily. CHILD: 6-11 yr: 2.5
mg; 1-5 yr: 1.25 mg; 6-11 mth: 1 mg.
Doses to be taken once daily

10-20 mg IM or SC, repeated if


required. Not to exceed 40 mg in 24
hrs. 10-20 mg over 1 min by slow IV

80

RM0.13/tab

RM1.01/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

R07 Other Respiratory System Products


No Generic Name
Cat Indications
Dosage
1 Beractant Intratracheal
A* Treatment of newborn baby 100 mg/kg (4 ml/kg) via endotracheal
Suspension (200 mg
with birth weight of 700 g or tube every 6 hrs (1 - 4 doses)
phospholipids in 8 ml.
greater undergoing
vial)
mechanical ventilation for
respiratory distress
(Survanta)
syndrome, whose heart rate
and arterial oxygenation are
continuously monitored

81

Remark
RM1555.60/
vial

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

SENSORY ORGANS

S01 Ophtalmologicals
No Generic Name
1 Amphotericin-B 0.15%
Eye Drops

Cat Indications
A Fungal infection of the
cornea

Dosage
1 drop hrly or 2 hrly

Remark
RM22.02/ea

Chloramphenicol 0.5%
Eye Drops

Broad spectrum antibiotic in 1 - 2 drops every 3-4 hrs


superficial eye infections

RM0.98/ea

Chloramphenicol 1% Eye
Ointment

Conjunctivitis and other


superficial eye infection

RM1.11/ea

Gentamicin 0.3% Eye


Drops

Gentamicin 3% Fortified
Eye Drops

Gentamicin 0.3% Eye


Ointment

Fusidic Acid 1% Eye


Ointment

A/KK Broad spectrum antibiotic in 1 - 2 drops every 4 hrs, in severe


superficial eye infections
infection dosage may be increased up
and also for Pseudomonas to 2 drops every hr
aeruginosa
A

Oxytetracycline with
Polymyxin B Sulphate
Eye Ointment

RM2.67/ea

Broad spectrum antibiotic in Dose according to the needs of the


superficial eye infections
patient
and also for Pseudomonas
aeruginosa

A/KK Conjunctivitis, blepharitis,


blepharo-conjunctivitis,
keratitis,
keratoconjunctivitis,
episcleritis, dacrocystitis,
corneal ulcers, styes and
infected eye socket

Apply into the conjunctival sac tds qid

RM2.95/ea

1 drop in conjunctival sac bd. To be


continued for 2 days after the eye
appears normal. On the first day of
treatment, may be applied more
frequently : 1 drop 4 hrly. Surgical
prophylaxis : 1 drop bd, 24-48 hrs
before operation

RM14.90/ea

For staphylococcal
infections

Conjunctivitis,
Apply into the conjunctival sac qid
dacryocystitis,
blepharoconjunctivitis,
keratitis, trachoma,
blepharitis, pre-op
prophylaxis against infection

RM1.33/tube

RM23.80/tube

(Fucithalmic)

Apply 1/2 inch of ointment every 3-4


times into the conjunctival sac

(Terramycin)

Acyclovir 3% Eye
Ointment

A*

Only for the treatment of


herpes simplex keratitis

10

Ciprofloxacin HCl 0.3%


Ophthalmic Solution
(Ciloxan)

A*

i) For corneal ulcer


i) 2 drops every 15 min for first 6 hrs,
ii) For bacterial conjunctivitis then 2 drops every 30 min for the rest
of the day. 2nd day : 2 drops every hr.
Subsequent days (3rd - 14th day) : 2
drops every 4 hrs. ii) 1-2 drops 2 hrly
into the conjunctival sac while awake
for 2 days and 1-2 drops 4 hrly while
awake for the next 5 days

RM5.00/ea

11

Betamethasone Disod
Phos 0.1% Eye Drops

Non-infected inflammatory
conditions of the eyes

1 - 2 drops every 1 - 2 hrs until


controlled then reduce frequency

RM2.18/ea

12

Fluorometholone 0.1%
Ophthalmic Suspension
(Flarex)

A*

Treatment of steroid
responsive ocular
inflammation

1-2 drops bd - qid

RM5.43/ea

82

Apply 1 cm 5 times dly. Continue for at


least 3 days after healing

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
13 Ketorolac Tromethamine
0.5% Eye drop
(Acular)

Cat Indications
A i) Ocular itching due to
allergic conjunctivitis
ii) Prophylaxis and reduction
of inflammation and
associated symptoms
following ocular surgery
A

Remark
RM15.30/ea

1-2 drops hrly for severe cases and 46 hrly for mild infection

RM6.28/ea

Apply 2-3 drops tds - qid

RM11.71/ea

14

Dexamethasone &
Neomycin Sulph &
Polymyxin B Sulph
Ophthalmic Suspension
(Maxitrol)

15

Framycetin Sulp 0.5%,


A/KK Otitis externa
Dexamethasone 0.05% &
Gramicidin 0.005% Ear
Drops (Sofradex)

16

Gentamicin Sulphate &


Betamethasone Disod
Phosphate Eye Drops
(Garasone)

17

Betamethasone Disod
Phos & Neomycin Sulp.
0.5% Eye Drops
(Betnesol-N)

Infected inflammatory
conditions of the eyes

2-3 drops every 2-3 hrs

RM2.78/bot

19

Pilocarpine 2% Eye
Drops

Miotics in chronic openangle glaucoma

1 drop od - qid

RM6.69/ea

20

Pilocarpine 4% Eye
Drops

21

Carbachol 0.01%
Intraocular Solution

For intraocular use for


miosis during surgery

22

Acetazolamide 500 mg
Injection

RM62.00/ea

23

Acetazolamide 250 mg
Tablet

Reduction of intra-ocular
250 - 500 mg given by IM or IV
pressure in open-angle
glaucoma, secondary
glaucoma and peri250 - 500 mg dly
operatively in angle-closure
glaucoma

24

hypromellose 0.3% Eye


Drops

A*

All glaucoma patients where


beta-blockers are
contraindicated and when
intraocular pressure is not
well controlled by other
drugs

Monotherapy: 1 drop tds.


Adjunctive therapy with an ophthalmic
beta-blocker: 1 drop bd. When
substituting for another ophthalmic
antiglaucoma agent with this product,
discontinue the other agent after
proper dosing on one day and start
Trusopt on the next day. If more than
1 topical ophthalmic drug is used, the
drugs should be administered at least
10 mins apart

RM48.70/ea

Elevated intraocular
pressure, chronic open
angle galucoma

Initially, 1 drop of 0.25% bd, if clinical


response is not adequate, 1 drop of
0.5% bd

RM19.45/ea

A/KK Inflammatory and allergic


2 drops tds - qid
conditions involving
superficial eye structures
and when bacterial infection
is present : conjunctivitis,
blepharitis, keratitis,
episcleritis, dacryocystitis,
hordeolum, meibomianitis,
injuries involving anterior
segment of the eye

(Artificial Tears)

25

Timolol Maleate 0.5%


Eye Drops

Treatment of ocular
inflammation when
concurrent use of an
antimicrobial is judged
necessary

Dosage
i) 1 drop qid
ii) 1 drop qid starting 24 hrs postoperation, continue for 2 wks

RM2.67/ea

RM10.24/ea

83

Instill not more than 1/2 ml gently into


the anterior chamber

RM16.75/vial

KPK
RM0.01/tab

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
26 Betaxolol 0.25% Eye
Suspension
(Betoptic)

Cat Indications
A Chronic open-angle
glaucoma, ocular
hypertension

Dosage
1-2 drops in the affected eye(s) bd

27

A*

Reduction of elevated
intraocular pressure in
patients with open-angle
glaucoma

1drop (1.5 g) in the affected eye(s)


od in the evening. If more than one
topical ophthalmic drug is being used,
the drugs should be administered at
least 5 min apart

RM16.50/ea

A*

Reduction of elevated
intraocular pressure in
patients with open angle
glaucoma or ocular
hypertension.

1drop in the affected eye(s) od in the


evening.

RM5.31/ea

Latanoprost 0.005% Eye


Drops
(Xalatan)

28

Travoprost 0.004% Eye


Drops
(Travatan)

Remark
RM22.54/ea

KPK

29

Atropine Sulphate 1%
Eye Drops

Determination of refraction,
strabismus, iritis and
iridocyclitis, after extra or
intracapsular extraction of
lens

Preoperative Mydriasis: 1 drop of a


1% solution supplemented with 1drop
of 2.5 or 10% phenylephrine prior to
surgery. Anterior Uveitis or
Posoperative Mydriasis: 1 drop of a
1% or 2% solution up to tds

RM6.39/ea

30

Cyclopentolate 1% Eye
Drops

Mydriasis and cycloplegia

1-2 drops several times a day.


Refractory procedures, ADULT : 1
drop of 0.5% solution. CHILD 6-12 yrs
: 1 drop of 1% solution. CHILD < 6 yrs
: 1-2 drops of 1% solution

RM19.45/ea

1-2 drops several times a day

RM19.87/ea

Mydriasis and vasoconstriction: 1 drop


of 2.5% or 10% solution, repeated in 1
hour if necessary. Chronic mydriasis:
1 drop of a 2.5% or 10% solution 2-3
times a day. Uveitis with posterior
synechiae (treatment) or synechiae,
posterior (prophylaxis): 1 drop of a
2.5% or 10% solution, repeated in 1
hour if necessary, not to exceed 3
times a day. Treatment may be
continued the following day, if
necessary

RM8.72/ea

(Cyclogyl)
31

Tropicamide 1% Eye
Drops
(Mydriacyl)

32

Phenylephrine HCl 2.5%


Eye Drops

A/KK Topical use to produce


cycloplegic refraction for
diagnostic purposes
B

(Mydfrin)

For pupillary dilation in


uveitis, for refraction without
cyclopegic. For fundoscopy
and other diagnostic
procedures

33

Antazoline HCL,
Tetrahydrozoline HCL &
Benzalkonium Cl Eye
Drops (Spersallerg)

A/KK Hay fever, conjunctivitis,


ADULT : Instill 1 drop tds - qid, into the
allergic conjunctivitis, vernal lower eyelid.
keratoconjunctivitis and
CHILD 2-12 yrs : Instill 1 drop od - bd
eczematosa

RM5.80/ea

34

Sodium Cromoglycate
2% Eye Drops

A/KK Prevention and treatment of 1 or 2 drops qid


allergic conjunctivitis
including seasonal and
perennial allergic
conjunctivitis and vernal
keratoconjunctivitis

RM6.88/ea

(Opticorm)

35

Proparacaine HCL 0.5%


Ophthalmic Drops

Topical anaesthesia in
ophthalmic procedures

(Alcaine)

84

Deep anaesthesia, 1 drop in each eye


every 5-10 min for 5-7 doses.
Superficial anaesthesia, 1-2 drops in
each eye before surgery or diagnostic
procedure. Tonometry and/or
tonography procedure, 1-2 drops in
each eye before procedure

RM8.50/15ml

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
36 Fluorescein 1 mg
Ophthalmic Strip
(Fluorets)

Cat Indications
B Diagnostic fluorescein
angiography or angioscopy
of the fundus and of the iris
vasculature

Dosage
Moisten tip with tear fluid from lower
fornix, sterile water or ophthalmic
solution and gently stroke across the
conjunctiva

Remark
RM0.57/ea

37

Sodium Chloride 0.9%


Eye Drops

Irrigation of conjunctival sac 1-2 drops every 3-4 hrs

RM2.56/ea

38

Hypromellose 0.3% Eye


Drops

Symptomatic relief of severe Instill 1-2 drops in affected eye(s) as


dry eye conditions and as
needed
lens lubricant during
ophthalmic diagnostic
procedures

RM3.74/10ml

Eyes disorders e.g. burns,


scalds, ulcers, prevention
and treatment of radiation
dermatitis, traumatic and
ischaemic wound

RM13.60/
20gm

(Artificial Tears)
39

Protein Free
Haemodialysate 20 %
Eye Gel
(Solcoseryl)

S02 Otologicals
No Generic Name
1 Ofloxacin 0.3% Otic
Solution
(Tarivid)

Cat Indications
A Acute otitis media with
tympanostomy tubes,
chronic suppurative otitis
media with perforated
tympanic membranes and
otitis externa

Instill 1 drop tds - qid

Dosage
Remark
RM0.96/ea
CHILD: 1-12 yrs: 5 drops bd for 10
days. ADULT and CHILD > 12 yrs: 6 10 drops bd and remain in the ear
about 10 min

Clotrimazole 1% Ear drop

Otomycosis; concomitant
4 to 5 drops 3 to 4 times daily
therapy with antibiotics and
corticosteroid ear drops

RM3.25/ea

Chloramphenicol 5% w/v
Ear Drops

Acute otitis media, otitis


externa with perforation

2-3 drops bd - tds. Not to be used for


long term

RM4.06/ea

Polymyxin B Sulph
10,000 U, Neomycin Sulp
5 mg & Hydrocortisone
10 mg Ear Drops
(Pocin-H / Otosporin)

Treatment of bacterial
infection and inflammation
of the external auditory
meatus

3 drops tds - qid. External auditory


meatus and canal to be thoroughly
cleansed and dried before each
application but soap should not be
used as the antibiotics may be
inactivated by it

RM5.80/ea

Olive Oil Ear Drops

Impacted wax softener

3-4 drops 3-4 or as directed

RM0.50/ea

Sodium Bicarbonate 5%
w/v Ear Drops

To soften the impacted ear


wax

2-3 drops tds - qid

RM0.50/ea

Dosage
2-3 drops every 2-3 hrs, reduce
frequency when relief obtained

RM2.18/ea

S03 Ophthalmological and Otological Preparations


No Generic Name
Cat Indications
1 Betamethasone Disod
B Non-infected inflammatory
Phos 0.1% Ear Drops
conditions
(Betnesol)
2

Betamethasone Disod
Phos & Neomycin Sulp
0.5% Ear Drops
(Betnesol-N)

Allergic dermatosis in the


ear

85

2-3 drops tds - qid, reduce frequency


when relief obtained

Remark

RM2.78/ea

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

VARIOUS

V03 All Other Therapeutic Products


No Generic Name
Cat Indications
1 Fuller's Earth 30 %
C Adsorbent in pesticide
Suspension
poisoning

Dosage
200-500 ml of Fuller's Earth together
with magnesium sulphate or mannitol
every 2 hrs for several days

Remark
RM61.50/
500gm

Pralidoxime 0.5g/20 ml
Injection

Antidote in the treatment of


organophosphorus
insecticide poisoning and in
the control of overdosage by
anticholinergic drugs used
in the treatment of
myasthenia gravis

1-2 g by IV infusion in 100 ml saline


over 15-30 min or slow IV injection
over 10 min as 5 % solution. In water,
followed after 1 hr by a second dose
of 1-2 g. CHILD: 20-40 mg /kg, may be
given depending on the severity and
response to treatment

RM73.19/amp

Protamine Sulphate
50mg/5ml inj

Heparin overdose and


following cardiac or arterial
surgery or dialysis
procedures when required
to neutralize the effects of
heparin administered during
extracorporeal circulation

RM33.66/ea

Naloxone HCl 0.4 mg/ml


(Adult) Injection

For the complete/partial


reversal of narcotic
depression including
respiratory depression
induced by opioids such as
natural and synthetic
narcotics. Diagnosis of
suspected acute opioids
overdosage

5 ml slow IV injected over 10 min. If


administered within 15 min of heparin
dose, 1 mg will neutralise
approximately 100 units of heparin. If
longer time has elapsed, less
protamine is required. Not more than
50 mg should be injected at any one
time
Initially 0.4 - 2 mg IV repeated at
intervals of 2-3 min according to
patient's needs

Methylene Blue 1%
Injection

For treatment of idiopathic


and drug-induced
methaemoglobinemia

1 to 2 mg/kg (0.1 to 0.2 mL/kg of a 1%


solution) IV very slowly over several
min

RM17.86/ea

Acetylcysteine 200 mg/ml


Injection

A*

Antidote for paracetamol


poisoning

Diluted with dextrose 5% and infused


IV. Initial, 150 mg/kg IV in 200 ml over
60 min, then 50 mg/kg IV in 500 ml
over 4 hrs, followed by 100 mg/kg IV
in 1000 ml over 16 hrs. Total dose:
300mg/kg in 20 hr

RM8.24/ea

Desferrioxamine B
Methanesulphonate 0.5 g
Injection

i) Acute iron poisoning in


children
ii) Investigation and
treatment of
haemochromatosis
iii) Diagnosis and treatment
of aluminium toxicity in
patients with renal failure
and dialysis
iv) Chronic iron toxicity or
overload

i) 2 g by IM immediately and 5 g by
mouth after gastric lavage
ii) 0.5 - 1.5 g by IM injection dly
iii) Diagnosis: 5 mg per kg by slow IV
infusion during the last hr of
haemodialysis. Treatment: 5 mg per
kg once a wk by slow IV infusion
during the last hr of dialysis
iv) 30-50 mg/kg

RM10.42/vial

Deferiprone 500mg
Tablet (Ferriprox)

A*

Treatment of iron overload 25 mg/kg tds for total daily dose of 75


mg/kg. Doses greater 100 mg/kg are
in patients with
not recommended
thalassaemia major for
whom desferrioxamine
therapy is contraindicated or
inadequate. Add on therapy
to desferrioxamine for
thallasaemia patients with
cardiac complication
86

RM2.32/amp

RM0.99/tab
BORANG E

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
9 Deferasirox 125 mg
Dispersible Tablet
(Exjade)
10

Deferasirox 500 mg
Dispersible Tablet
(Exjade)

Cat Indications
A* Treatment of chronic iron
overload due to blood
transfusions (transfusional
haemosiderosis) in adult
A*
and pediatric patients aged
2 years and above

Dosage
Remark
Initial 20 mg/kg/day. Starting dose can RM23.14/tab
also be based on transfusion rate and
Borang E
existing iron burden. Max is 30
mg/kg/day
RM92.61/tab
Borang E

Flumazenil 0.5 mg/5 ml


Injection

i) Diagnosis and/or
management of
benzodiazepine overdose
due to self-poisoning or
accidental overdose
ii) Reversal of sedation
following anaesthesia with
benzodiazepine

12

Calcium Polystyrene
Sulphonate Powder
(Kalimate)

Hyperkalemia resulting from 15-30g dly in 2-3 divided doses. Each


acute or chronic renal failure dose should be suspended in 30 50ml of water and administered orally

RM1.59/5gm

13

Mesna 400mg/4ml
Injection

For prevention of urotoxic


effects of
oxazaphosphorines e.g.
ifosfamide and
cyclophosphamide

IV injection at a dosage of 20% of the


corresponding oxazaphosphorine
dose at the times 0 hr (concurrently
with the oxazaphosphorine), 4 hrs and
8 hrs thereafter. CHILD: Dose given at
greater frequency (e.g. 6 times) and a
shorter intervals (e.g. 3 hrs)

RM7.88/vial

i) Biochemical modulator for


5-Fluorouracil in the
treatment of colorectal
cancer
ii) As rescue for high dose
methotrexate
iii) Gestational trophoblastic
disease

i) 20 mg/m2 dly for 5 days before 5Fluorouracil or 200 mg/m2 IV infusion


over 2 hrs prior to 5-Fluorouracil on
Day 1 & Day 2 or 500 mg/m2 IV Day 1
wkly (refer to specific protocol)
ii) Starting 24-42 hrs of methotrexate
administration, doses usually 15-30
mg/m2 every 6 hrs for 8-12 doses
depending on protocol and serum
methotrexate levels
iii) 6-12 mg exactly 30 hrs after each
dose of methotrexate. In EMA-CO
regime for high risk gestational
trophoblastic disease, use 30 mg IM

RM11.60/vial

(Uromitexan)

14

Leucovorin Calcium
(Calcium Folinate) 50 mg
Injection

87

i) Initial, 0.2 mg IV over 30 secs; if


desired level of consciousness not
obtained after an additional 30 secs,
give dose of 0.3 mg IV over 30 secs;
further doses of 0.5 mg IV over 30
secs may be given at 1-min intervals if
needed to max. total dose of 3 mg;
patients with only partial response to 3
mg may require additional slow
titration to a total dose of 5 mg; if no
response 5 min after receiving total
dose of 5 mg, overdose is unlikely to
be benzodiazepine and further
treatment with flumazenil will not help
ii) 0.2 mg IV over 15 secs; if desired
level of consciousness is not obtained
after waiting 45 secs, a 2nd dose of
0.2 mg IV may be given and repeated
at 60-secs intervals as needed (up to
a max of 4 additional times) to a max
total dose of 1 mg; most patients
respond to doses of 0.6-1 mg; in the
event of resedation, repeated doses
may be given at 20-min intervals if
needed; for repeat treatment, no more
than 1 mg (given as 0.5 mg/min)
should be given at any one time and
no more than 3 mg should be given in
any one hr

RM35.00/amp

11

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

No Generic Name
15 N-Acetylcysteine 600mg
Tablet

V04 Diagnostic Agents


No Generic Name
1 Dextrose Powder
2

Tuberculine PPD
Injection

Cat Indications
Dosage
Prevention of contrast
For each course is 600mg BD x 3/7
induced nephropathy in high
risk group patients

Cat Indications
B Use as a diagnostic agent
for diabetes
B

For routine Mantoux


(tuberculin sensitivity) test

Remark
RM2.55/tab

KPK

Dosage
75 g stat

RM5.64/kg

10 units is injected intradermally

RM74.58/ea

V07 All Other Non-Therapeutic Products


No Generic Name
Cat Indications
Dosage
1 Water for Injection
C As a diluent and vehicle for According to the needs of the patient
the administration of
medications

Remark

Remark
RM0.28/10ml,
RM2.27/
500ml

Sodium Hypochlorite
10% Solution

Low-level disinfectant and


antiseptic

Antiseptic: less than 0.5%.


Disinfectant: 5%

RM2.94/kg

Sodium
Dichloroisocyanurate 2.5
g Tablet

Low and medium level


disinfectant

50 - 10,000 ppm av chlorine

RM0.37/tab

Hydroxyethyl Cellulose
Jelly (KY Jelly)

For lubricating purpose

Apply sufficiently for lubricating


purpose

RM3.20/ea

88

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

INDEX
A
Acarbose Tablet

Acetazolamide Tablet, Injection

82

Acetylcysteine Injection

85

Acetylcysteine Tablet

87

Acetylsalicylic Acid + Glycine Tablet

10

Acetylsalicylic Acid Soluble Tablet

62

Acitretin Capsule

24

Acriflavine Lotion

26

Actinomycin D Injection

50

Acyclovir Tablet, Injection

42

Acyclovir Eye Ointment

81

Acyclovir Cream

25

Adefovir Dipivoxil Tablet

44

Adenosine Injection

17

Adrenaline Acid Tartrate Injection

17

Albendazole Tablet, Suspension

75

Alcohol Solution

26

Alendronate Sodium and Cholecalciferol Tablet

58

Alfacalcidol Capsule, Drops, Injections

6,7

Alfuzosin HCI Tablet

30

Allopurinol Tablet

58

Alprazolam Tablet

69

Alprostadil Injection

17

Amantadine Tablet

65

Amikacin Injection

39

Amino Acids Injection

13

Amino Acids with Electrolytes Injection

14

Amino Acids with Taurine Injection

13

Aminophylline Injection

79

Amiodarone Injection

16

Amiodarone Tablet

16

Amisulpride Capsule

68

Amitriptyline HCl Tablet

70

Amlodipine Tablet

20

Amlodipine & Valsartan Tablet

22

Amoxicillin & Clavulanate Syrup, Injection, Tablet

35

Amoxicillin Capsule, Suspension

34

Amphotericin B Injection

40

Amphotericin-B Eye Drops

81

Ampicillin & Sulbactam Suspension, Tablet, Inj

35

Ampicillin Sodium Injection

Anastrozole Tablet

54

Antazoline HCL, Tetrahydrozoline HCL &


Benzalkonium Cl Eye Drops

83

Anti RhD Gamma Globulin Injection

45

Antivene Serum Snake Polyvalent Injection

45

Antivenene Malaysian Pit Viper Injection

45

Antivenene Serum (Cobra) Injection

45

Antivenene Serum (Sea snake) Injection

45

Aqueous Cream

23

Aripiprazole Tablet

68

Artemether + Lumefantrine

74

Ascorbic Acid Tablet

Atenolol Tablet

19

Atorvastatin Tablet

22

Atracurium Besylate Injection

57

Atropine Sulphate Eye Drops

83

Atropine Sulphate Injection

Azathioprine Tablet

55

Azithromycin Injection

38

Azithromycin Tablet

38

34
89

Bacampicillin Tablet

34

Baclofen Tablet

57

Balanced Salt Solution

14

BCG.Freeze-dried Vaccine Injection

46

Beclomethasone Dipropionate Inhalation

77

Beclomethasone Dipropionate Nasal Spray

76

Benzalkonium & Cetrimide Cream

26

Benzathine Penicillin Injection

34

Benzhexol Tablet

65

Benzoic Acid Compound Ointment

23

Benzoin Compound Tincture

26

Benzoyl Peroxide Gel

27

Benzydamine HCl Solution

Benzyl Benzoate Emulsion

75

Benzylpenicillin Injection

34

Beractant Intratracheal Suspension

81

Betahistine Tablet

73

Betamethasone 17 - Valerate Cream, Ointment

25

Betamethasone & Neomycin Ear Drops

84

Betamethasone & Neomycin Eye Drops

82

Betamethasone Disod Phos Ear Drops

84

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Betamethasone Disod Phos Eye Drops

81

Ceftriaxone Injection

36

Betaxolol Eye Suspension

83

Cefuroxime Axetil Suspension

35

Bicalutamide Tablet

54

Cefuroxime Sod Injection, tablet

36

Bisacodyl Suppository, Tablet

Celecoxib Capsule

56

Bismuth Subgallate & Benzyl Benzoate Supp

18

Cephalexin Monohydrate Syrup, Capsule

35

Bismuth Subnitrate, Iodoform & Liq Paraffin Paste

76

Cetirizine HCl Tablet

80

Bisoprolol Fumarate Tablet

19

Cetrimide Lotion

26

Bleomycin HCl Injection

51

Charcoal, Activated Tablet, Granules

Bromhexine HCl Injection, Elixir, Tablet

80

Chloral Hydrate Mixture

70

Bromazepam Tablet

69

Chlorambucil Tablet

47

Bromocriptine Mesylate Tablet

28

Chloramphenicol Eye Drops, Eye Ointment

81

Budesonide & Formoterol Inhalation

77

Chloramphenicol Ear Drops

84

Budesonide Inhalation

77

Chlorhexidine Gluconate Mouthwash

76

Budesonide Nasal Spray

76

Chlorhexidine Gluconate Solution

26

Budesonide Nebulising Solution

77

Chloroquine Phosphate Tablet

74

Bupivacaine Heavy Injection

59

Chlorpheniramine Maleate Injection, Syrup

80

Bupivacaine Injection

59

Chlorpheniramine Maleate Tablet

80

Bupivacaine with Adrenaline Injection

60

Chlorpromazine Tablet

66

Chlortetracycline Cream

24

Cinnarizine Tablet

73

Calamine Cream, Lotion

24

Ciprofloxacin Injection, Tablet

39

Calamine with Precipitated Sulphur Lotion

24

Ciprofloxacin HCl Ophthalmic Solution

81

Calcipotriol Ointment

24

Cisplatin Injection

51

Calcipotriol + Betamethasone Ointment

24

Clarithromycin Tablet

38

Calcitonin Nasal Spray, Injection

33

Clindamycin HCl Capsule

38

Calcitriol Capsule

Clindamycin Phosphate Injection

38

Calcium Carbonate Tablet

Clobazam Tablet

69

Calcium Gluconate Injection

Clobetasol Propionate Cream, Ointment

25

Calcium Lactate Tablet

Clobetasone Butyrate Cream, Ointment

25

Calcium Polystyrene Sulphonate Powder

86

Clomifene Citrate Tablet

30

Capecitabine Tablet

49

Clomipramine HCl Tablet

70

Captopril Tablet

20

Clonazepam Tablet

62

Carbachol Intraocular Solution

82

Clopidogrel Tablet

Carbamazepine Tablet

63

Clotrimazole Cream

23

Carbimazole Tablet

33

Clotrimazole vaginal Tablet

28

Carboplatin Injection

51

Clotrimazole ear drop

84

Carboprost Tromethamine Injection

28

Cloxacillin Sodium Capsule, suspension

34

Carvedilol Tablet

20

Cloxacillin Sodium Injection

34

Caspofungin Acetate Injection

41

Clozapine Tablet

67

Cefepime Injection

36

Coal Tar Solution

24

Cefoperazone & Sulbactam Injection

36

Cocaine Solution

60

Cefoperazone Sodium Injection

36

Cocois Co. Ointment

24

Cefotaxime Injection

36

Colchicine Tablet

58

Ceftazidime Injection

36

Colistin (Polymyxin E)

39

90

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Conjugated Oestrogens Tablet, Cream

29

Doxazosin Mesylate CR Tablet

18

Crotamiton Cream

75

Doxorubicin HCl Injection

51

Cyanocobalamin Injection, Table

12

Doxycycline Capsule

34

Cyclopentolate Eye Drops

83

Dutasteride Capsule

30

Cyclophosphamide Injection, Tablet

47

Dutasteride + Tamsulosin Capsule

30

Cyclosporin Capsule Microemulsion

55

Dydrogesterone HCI Tablet

29

Cytarabine Injection

49

E
D

Efavirenz Capsule, Tablet

44

Dabigatran capsule

10,11

Emulsificants Ointment

23

Dacarbazine Injection

48

Enalapril Tablet

20

Danazol Capsule

30

Enoxaparin Sodium Injection

Dapsone Tablet

41

Entacapone Tablet

65

Deferasirox tablet

86

Eperisone HCl Tablet

57

Deferiprone Tablet

85

Ephedrine HCl Injection

78

Desferrioxamine B Methanesulphonate Injection

85

Ephedrine Nasal Drop

76

Desflurane Liquid

59

Epirubicin Injection

51

Desloratadine tablet

80

Erlotinib tablet

52

Desmopressin Tablet, Nasal Spray

31

Erythromycin Ethylsuccinate Tablet, Suspension

37

Dexamethasone & Neomycin Sulph & Polymyxin B


Sulph Ophthalmic Suspension

Erythromycin Lactobionate Injection

38

82

Dexamethasone Tablet
Dexamethasone Sodium Phosphate Injection

31

Erythropoietin Human Recombinant Prefilled


Syringes (Eprex).

13

32

Escitalopram Tablet

71

Dexchlorpheniramine Maleate Tablet, Syrup

80

Esomeprazole Tablet

Dextrose Injection

14

Essential Phospholipid Capsules

Dextrose Powder

87

Estradiol & Estradiol with Dydrogesterone 10mg

29

Diazepam Injection

69

Estradiol Valerate Tablet

28

Diazepam Tablet

69

Estradiol Valerate & Norgestrel 0.5mg Tablet

29

Diclofenac Emulgel

57

Ethambutol HCl Tablet

41

Diclofenac Sodium Tablet, Injection

56

Ether Solvent

59

Diethylcarbamazine Citrate tablet

75

Ethyl Chloride Spray

61

Digoxin Tablet, Injection

16

Etomidate Injection

59

Diltiazem HCl Tablet

20

Etoposide Injection

50

Dinoprostone Vaginal Tablet

28

Etoricoxib Tablet

56

Diosmin & Hesperidin Tablet

19

Exemestane tablet

54

Diphenhydramine HCl & Ammonium Chloride


Expectorant

Ezetimibe tablet

22

80

Diphenoxylate with Atropine Sulphate Tablet

Dipyridamole Tablet

10

Dobutamine HCl Injection

17

Docetaxel Injection

50

Domperidone Tablet

Donepezil HCl Tablet

72

Dopamine HCl Injection

16
71

Dothiepin HCl Capsule, Tablet

91

Factor VIII Injection

12

Fat Emulsion 20% for IV Infusion

13

Felodipine Tablet

20

Fentanyl Transdermal Patch

61

Fentanyl Citrate Injection

59

Ferric Ammonium Citrate Paed Mixture

12

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Ferrous Fumarate Tablet

12

Gliclazide Tablet

Filgrastim (G-CSF) Injection

54

Glycerin

Finasteride Tablet

30

Glycerin & Sodium Chloride Disposable Enema

Flecainide Acetate Tablet

16

Glyceryl Trinitrate Tablet, Injection

17

Fluconazole Capsule

40

Goserelin Depot Injection

54

Fluconazole Injection

40

Granisetron HCl Injection

Fludrocortisone Acetate Tablet

31

Flumazenil Injection

86

Flunarizine HCl Capsule

73

Fluorescein Ophthalmic Strip

84

Fluorometholone Ophthalmic Suspension

81

Fluorouracil Injection

48

Fluoxetine HCL Capsule

71

H
Haemophilus Influenzae Type B Conjugate Vaccine

46

Haloperidol Tablet

66

Heparin Injection

Heparin Sodium in Sodium Chloride Injection

Hepatitis B Immunoglobulin (Human) Injection

45

Hepatitis B Vaccine Injection

46

Human Albumin Injection

13

Hydralazine Injection

18

Hydrochlorothiazide Tablet

18

Hydrocortisone Cream, Ointment

25

Hydrocortisone Enema

82

Hydrocortisone Tablet

32

Frusemide Injection, Tablet

18

Hydrocortisone Sodium Succinate Injection

32

Fuller's Earth Suspension

85

Hydrogen Peroxide Solution

26

Fusafungine Nasal Spray

76

Hydroxychloroquine Sulphate Tablet

74

Fusidic Acid Eye Ointment

81

Hydroxyethyl Cellulose Jelly

87

Fusidic Acid Cream

25

Hydroxyethyl Starch Injection

13

Fusidic Acid in Betamethasone Valerate Cream

26

Hydroxyurea Capsule

53

Fusidic Acid Tablet, Injection

39

Hydroxyzine HCl Tablet

70

Hyoscine N-Butylbromide Tablet, Injection

Hypromellose Eye Drops

82,84

Flupenthixol Decanoate Depot lnjection

66

Fluphenazine Decanoate Injection

66

Fluticasone Propionate Inhalation

78

Fluvoxamine Tablet

71

Folic Acid Tablet

12

Fondaparinux Injection
Framycetin Sulp, Dexamethasone & Gramicidin Ear
Drops

11

G
Gabapentin Capsule

64

Gamma Benzene Hexachloride Lotion

75

Ganciclovir Sodium Injection

42

Ibandronic Acid Tablet

58

Gefitinib Tablet

52

Ibuprofen Tablet

56

Gemcitabine HCl Injection

49

Ifosfamide

47

Gemeprost Pessary

28

Imipenem & Cilastatin Injection

37

Gemfibrozil Capsule

22

Imipramine HCl Tablet

70

Indinavir Sulphate Capsule

43

Gentamicin Eye Drops, Eye Ointment, Fortified Eye


Drop

81

Indomethacin Capsule

56

Gentamicin Beads

38

Insulin Aspart

Gentamicin Sulphate & Betamethasone Disod


Phosphate Eye Drops

82

Insulin Glargine

Gentamicin Sulphate Injection

39

Insulin Recombinant Synthetic Human, Intermediate


-acting vial Penfill and Refill

Glibenclamide Tablet

Gliclazide Modified Release Tablet

Insulin Recombinant Synthetic Human, Pre-mixed


Penfill

92

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Lignocaine Injection

16

Insulin Recombinant Synthetic Human, short-acting


Penfill and Refill

Iodine & Potassium Iodide Solution

33

Lignocaine, Aluminium Acetate, Zinc Oxide &


Hydrocortisone Suppository

18

Ipratropium Inhalation,Inhalation Solution

78

Liquid Paraffin

Ipratropium Bromide & Salbutamol Inhalation

77

Lithium Carbonate Tablet

68

Ipratropium Bromide and Fenoterol Inhalation

77

Lopinavir and Ritonavir Tablet, Solution

43

Irbesartan Tablet

21

Loratadine Syrup, Tablet

80

Irinotecan HCl Trihydrate Injection

53

Loratadine & Pseudoephedrine Sulphate

76

Iron Dextran Injection

12

Lorazepam Tablet

69

Isoniazid Tablet

41

Losartan Tablet

21

Isosorbide Dinitrate Tablet

17

Losartan Potassium & Hydrochlorothiazide Tablet

21

Isosorbide Mononitrate SR Capsule

17

Lovastatin Tablet

22

Isotretinoin Capsule

27

L-Thyroxine Sodium Tablet

31

Itopride HCL Tablet

Itraconazole Capsule

40

Ivabradine Tablet

17

Magnesium Sulphate Injection

15

Magnesium Trisilicate Mixture

Magnesium Trisilicate Tablet

Ketamine Injection

59

Mannitol Injection

14

Ketoconazole Shampoo

23

Mebeverine HCL Tablet

Ketoconazole Tablet

40

Mecobalamin Tablet

58

Ketorolac Tromethamine Eye drop

82

Medroxyprogesterone Acetate Tablet

29

Mefenamic Acid Capsule

56

Meloxicam Tablet

56

L
Labetalol HCl Injection, Tablet

19

Memantine Tablet

72

Lactulose Liquid

Meningococcal A, C, Y, W135 Vaccine Injection

46

Lamivudine Oral Solution

44

Menthol in Ind. Methylated Spirit Inhalation

76

Lamivudine Tablet

44

Meropenem Injection

36

Lamotrigine Tablet

63

Mesna Injection

86

Lamotrigine Dispersible/ Chewable Tablet

63

Metformin & Glibenclamide Tablet

L-Aspariginase Injection

52

Metformin HCl Tablet

Lapatinib Tablet

53

Methotrexate Injection, Tablet

48

Latanoprost Eye Drops

83

Methoxsalen Capsule

24

Letrozole Tablet

54

Methyl Salicylate Ointment

57

Leucovorin Injection

86

Methyldopa Tablet

17

Leuprolide Acetate Injection

54

Methylene Blue Injection

85

Levetiracetam Tablet

64

Methylphenidate HCl Tablet, Extended Release Tab

72

Levodopa & Carbidopa Tablet

65

Methylprednisolone Sodium Succinate Injection

32

Levodopa, Benserazide HBS capsule

65

Metoclopramide HCl Tablet, Injection

Levodopa, Benserazide Tablet

65

Metoprolol Tartrate Tablet

19

Levonorgestrel Releasing Intrauterine System

28

Metronidazole Tablet

74

Levothyroxine Tablet

32

Metronidazole Injection

39

Lidocaine and Prilocaine Cream

60
60

Miconazole Cream

23

Midazolam Injection, Tablet

70

Lignocaine HCl Injection, Jelly, Spray

93

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Minoxidil Tablet

18

Mirtazapine Orodispersible Tablet

71

Paclitaxel Injection

50

Mitomycin-C Injection

51

Paliperidone Extended Release Tablet

68

Moclobemide Tablet

71

Pamidronate Disodium Injection

58

Modified Fluid Gelatin Injection

13

Pantoprazole Tablet, Injection

Mometasone Cream

25

Paracetamol Syrup, Suppository, Tablet

62

Mometasone Furoate Aqueous Nasal Spray

76

Paraffin, White Soft

23

Monobasic Sodium Phosphate, Dibasic Sodium


Phosphate

Parecoxib Sodium Injection

56

Pentoxifylline Tablet

18

Montelukast Sodium Tablet, Oral Granule, Chewable


Tablet

79

Morphine HCl Solution

61

Morphine Sulphate Injection

61

Multivitamin Syrup, Injection

Mupirocin Ointment

25

Mycophenolate Mofetil Tablet

55

N
Naloxone HCl (Adult) Injection

85

Naproxen Tablet

56

Neomycin Cream

25

Neostigmine Methylsulphate Injection

73

Nevirapine Tablet

44

Nifedipine Tablet

20

Noradrenaline Bitartrate Injection

16

Nystatin Cream

23

Nystatin Suspension

O
Octreotide Injection

31

Ofloxacin Otic Solution

84

Ofloxacin Tablet

39

Olanzapine Tablet

67

Olive Oil Ear Drops

84

Omeprazole Capsule, Injection

Oral Rehydration Salt

Oxaliplatin Injection

52

Oxycodone Tablet

61

Oxycodone Immediate Release Tablet

61

Oxymetazoline HCl Nasal Spray (Paed), (Adult)

76

Oxytetracycline with Polymyxin B Sulphate Eye


Ointment

81

Oxytocin Injection

31

Oxytocin 5 units & Ergometrine Maleate Injection

28

94

Perindopril Tablet

21

Peritoneal Dialysis with Glucose Solution

14

Perphenazine Tablet

66

Pethidine HCl Injection

61

Phenobarbitone Tablet, Injection

62

Phenoxymethyl Penicillin Tablet, Suspension

34

Phenylephrine HCl Eye Drops

83

Phenytoin Sodium Capsule

62

Phenytoin Sodium Injection

62

Phosphate Sandoz

15

Pilocarpine Eye Drops

82

Piperacillin & Tazobactam Injection

35

Piracetam Tablet

72

Pizotifen Tablet

62

Pneumococcal Vaccine (Polyvalent)

46

Polymyxin B Sulphate, Neomycin Sulphate &


Hydrocortisone Ear Drops

84

Polyethylene Glycol/ Macrogol 4000 Powder

Potassium Chloride (SR) Tablet

Potassium Chloride Injection

14

Potassium Chloride Mixture

Potassium Citrate & Citric Acid Mixture

Potassium Dihydrogen Phosphate Injection

15

Potassium Permanganate Solution

26

Povidone Iodine Solution

26

Pralidoxime Injection

85

Pramipexol Tablet

65

Pravastatin Sodium Tablet

22

Prazosin HCl Tablet

17

Prednisolone Tablet

32

Pregabalin Capsule

64

Primaquine base Tablet

74

Procaine Benzylpenicillin Aqueous Injection

34

Prochlorperazine Maleate Tablet, Injection

66

Procyclidine HCl Injection

65

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Prolase Tablet

58

Selegiline HCl Tablet

65

Promethazine HCl Injection, Syrup

80

Selenium Sulphide Shampoo

27

Proparacaine HCL Ophthalmic Drops

83

Sertraline HCL Tablet

71

Propofol Injection

59

Sevoflurane Liquid

59

Propranolol HCL Tablet

19

Silver Sulphadiazine Cream (SSD)

25

Propylthiouracil Tablet

32

Simvastatin Tablet

22

Protamine Sulphate Injection

85

Sodium Bicarbonate Ear Drops

84

Protein Free Haemodialysate Jelly

24

Sodium Bicarbonate Injection

14

Protein Free Haemodialysate Eye Gel

84

Pyrazinamide Tablet

41

Sodium Bicarbonate, Citric Acid, Sodium Citrate and


Tartaric Acid

14

Pyridostigmine Bromide Tablet

73

Sodium Bicarbonate, Magnesium Carbonate,


Tincture Cardamom Compound Mixture

Pyridoxine HCl (Vitamin B6) Tablet

Sodium Biphosphate & Sodium Phosphate Enema

Pyrimethamine Tablet

75

Sodium Chloride (Half Strength) Injection

15

Sodium Chloride with Dextrose Injection

15

Q
Quetiapine Fumarate (Extended Release) Tablet

67

Quinine Dihydrochloride Injection

74

Quinine Sulphate Tablet

74

R
Rabies Human Diploid Cell Vaccine (Lyophilised)
Injection

46

Raloxifene HCl Tablet (Evista)

30

Ramipril Tablet

21

Ranitidine Tablet

Sodium Chloride Eye Drops

84

Sodium Chloride Injection

15

Sodium Citrate, Citric Acid Mixture

14

Sodium Cromoglycate Eye Drops

83

Sodium Dichloroisocyanorate Tablet

87

Sodium Hypochlorite Solution

87

Sodium Lactate Compound

15

Sodium Tetradecyl Sulphate Injection

19

Sodium Thiosulphate Solution

23

Sodium Valproate Tablet, Syrup

63

Somatropin Injection

31

Spironolactone Tablet

18

Stavudine Capsule

43

Stavudine & Lamivudine & Nevirapine Tablet

44

Ranitidine Injection

Riboflavine Tablet

Rifampicin Capsule

41

Risperidone Tablet, Oral Solution

68

Streptokinase Injection

10

Risperidone Long Acting Injection

68

Streptomycin Sulphate Injection

38

Ritonavir Capsule

43

Sucralfate Tablet

Rivastigmine Capsule

72

Sulfadoxine & Pyrimethamine Tablet

74

Rivastigmine Transdermal Patch

72

Sulfamethoxazole & Trimethoprim Suspension

37

Sulfamethoxazole & Trimethoprim Tablet, Inj

37

Sulpiride Tablet

67

Rocuronium Bromide Injection

57

Ropivacaine HCl Injection

60

Suxamethonium Chloride lnjection

57

Synthetic Vitamin K1 Injection

11

Salbutamol Inhalation Solution

77

Salbutamol Injection, Tablet, Syrup

78,79

Tacrolimus Tablet

55

Salbutamol Inhalation

77

Tamoxifen Citrate Tablet

54

Salicylazosulphapyridine (Sulphasalazine) Tablet

Tamsulosin Tablet

30

Salicylic Acid Ointment, Cream

23

Tar, Coal Tar and Oleyl Alcohol Liquid

24

Salmeterol & Fluticasone Evohaler

77

Telmisartan Tablet

21

Telmisartan & Hydrochlorothiazide Tablet

22

Telmisartan & Amlodipine Tablet

22

Salmeterol & Fluticasone Propionate Inhalation

77
95

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

Tenecteplase Injection

10

Tuberculine PPD Injection

87

Tenofovir Tablet

43

Typhoid Vaccine Injection

46

Tenofovir + Emtricitabine (Truvada) Tablet

44

Terazosin HCl Tablet

30

Terbinafine HCL Tablet

23

Urea Cream

23

Terbutaline Sulphate Injection

79

Urokinase Injection

10

Terbutaline Sulphate Inhalation Solution

77

Ursodeoxycholic Acid Capsule

Testosterone Injection

28

Tetanus Immunoglobulin, Human Injection

45

Tetanus Toxoid Injection

46

Valsartan & Hydrochlorothiazide Tablet

Theophylline Tablet

79

Valsartan Tablet

21

Theophylline Long Acting Tablet

79

Vancomycin HCl 500 mg Injection

39

Thiamine Mononitrate Tablet

Vecuronium Bromide Injection

57

Thiopental Sodium Injection

70

Venlafaxine Hydrochloride Extended Release Cap

71

Thymol Compound Gargle

Verapamil HCl Tablet, Injection

20

Tibolone Tablet

29

Vinblastine Sulphate Injection

49

Ticlopidine HCl Tablet

10

Vincristine Sulphate Injection

49

Timolol Maleate Eye Drops

82

Vinorelbine Injection

50

Tiotropium Bromide Inhalation Cap & Handihaler

78

Vitamin B Complex Tablet

Tolterodine L-Tartrate Tablet

30

Vitamin B1, B6, B12 Tablet

Topiramate Tablet

64

Topiramate Capsule Sprinkle

64

Trace Elements and Electrolytes (Adult) Solution

15

Warfarin Sodium Tablet

Trace Elements and Electrolytes (Paed) Solution

15

Water for Injection

87

Tramadol HCl Capsule, Injection

61

Tranexamic Acid Injection, Capsule

11

22

Travoprost Eye Drops

83

Zidovudine Injection

43

Tretinoin Gel, Cream

27

Zidovudine Syrup, Capsule

43

Triamcinolone Acetonide In Dental Paste

Zidovudine + Lamivudine (Combivir) Tablet

44

Triamcinolone Acetonide Injection

32

Zinc Oxide Ointment

23

Trifluoperazine HCl Tablet

66

Zoledronic Acid Injection

58

Trimetazidine Tablet

17

Zuclopenthixol Drops

67

Trimethoprim Tablet

37

Zuclopenthixol Acetate Injection

67

Triprolidine HCl & Pseudoephedrine HCl Syrup

76

Zuclopenthixol Decanoate Depot Injection

67

Triptorelin Injection

54
83

Tropicamide Eye Drops

96

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013


APPENDIX 1

Adverse Drug Reactions (ADR) Reporting Form


Please report all suspected ADRs that may be related to a drug, or a combination of drugs using the form
below. Do not hesitate to report if some details are not known. ADR forms can be obtained from Pharmacy
Department. Please send the completed form to Drug Information Unit, Pharmacy Department or submit the
report online via the internet at www.bpfk.gov.my.

97

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013


APPENDIX 2

BORANG PERMOHONAN KAD ALAHAN UBAT


99
(DRUG ALLERGY CARD
REQUEST FORM)

JABATAN FARMASI HOSPITAL PAKAR SULTANAH FATIMAH, MUAR


A. MAKLUMAT PESAKIT
Nama : _________________________________________________
Jantina : Lelaki / Perempuan

R/N:________________

Bangsa : ________________

No Kad Pengenalan

Alamat : ___________________________________

No. Telefon - (Rumah) : __________________

__________________________________

- (Bimbit) : __________________

__________________________________
__________________________________

Alamat e-mel : _________________________

Jika warganegara asing, sila isi maklumat berikut:


No. Passport: ______________________

Warganegara: _____________ Umur: __________

B. JENIS PERMOHONAN

. MAK
PERMOHONAN KAD BARU

PERMOHONAN TAMBAHAN MAKLUMAT PADA KAD


No. Siri Kad Alahan Ubat : DAC _________________________
Tarikh kad dikeluarkan

Bil.

Nama Ubat Yang Terlibat

Reaksi Alahan

1.
2.

C. MAKLUMAT PEMOHON
Nama dan tandatangan

Nombor telefon

Wad / Unit

Hospital/ Klinik

Alamat

Cop Jawatan

Tarikh

: _____________________________

98

Hospital Drug Formulary, Hospital Pakar Sultanah Fatimah 2013

D. UNTUK KEGUNAAN FARMASI


No. Siri Kad

: DAC_________________________

Tarikh Kad dikeluarkan

: _____________________________

Nama dan tandatangan


Pegawai Farmasi

Cop Jawatan

Tarikh

LULUS

TOLAK
Nyatakan sebab: __________________________________________
________________________________________________________
________________________________________________________

E. PENGESAHAN PENERIMAAN OLEH PESAKIT

pesakit/penjaga

Saya
nombor

kad

pengenalan

dengan ini telah menerima kad

alahan dan telah diberi penerangan sewajarnya berkaitan keperluan memaklumkan atau menunjukkan kad
alahan tersebut apabila berjumpa pegawai perubatan, pegawai farmasi, pegawai pergigian atau anggota
kesihatan lain.

Tandatangan
Pesakit / Penjaga :

Tandatangan dan cop


Pegawai Farmasi

Tarikh

Tarikh

99

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