Professional Documents
Culture Documents
Q4
Buprenorphine
A.
B.
C.
D.
is a?
Partial mu agonist
Full mu agonist
Partial kappa agonist
Full kappa agonist
Indinavir
Elvitegravir
Saquinavir
Raltegravir
Euphoria
Miosis
Analgesia
Nausea
A. Dose reduction
B. Liposomal delivery systems
C. Supplementing glucose
D. Giving it along with flucytosine
A. Phenytoin
B. Diazepam
C. Morphine
D. Heparin
d) Aquaretic
Correct answer: d) Aquaretic
Q24
Mineralocorticoid Receptors are found in all of the following, Except?
A. Liver
B. Colon
C. Hippocampus
D. Kidney
Correct answer : A. Liver
Q25
All of the following are known adverse effects of thalidomide, except:
A. Diarrhoea
B. Teratogenicity
C. Deep Vein Thrombosis
D. Peripheral Neuropathy
Correct answer : A. Diarrhoea
Q26
Which of the following antihypertensive drugs should not be used in a
patient on Lithium in order to prevent Lithium Toxicity?
A. Clonidine
B. Beta blockers
C. Calcium Channel Blockers
D. Diuretics
Correct answer : D. Diuretics
Q27
Alkalinization of urine is done during administration of which of the
following chemotherapeutic drugs?
A. Ara-C (Cytarabine)
B. Methotrexate
C. Cisplatin
D. Ifosfamide
Correct answer : B. Methotrexate
Q28
Which of the following agents is used for the treatment of
Thrombocytopenia secondary to myelosuppressive cancer chemotherapy?
A. Filgrastim
B. Sargramostim
C. Oprelvekin
D. Erythropoietin
Correct answer : C. Oprelvekin
Q29
All of the following statements about Aprepitant are true except?
A. Agonist at Neurokinin receptor (NK1)
B. Crosses blood brain barrier
C. Metabolised by CYP3A4 pathway
D. Ameliorates nausea and vomiting of chemotherapy
Correct answer : A. Agonist at Neurokinin receptor (NK1)
Q30
All of the following statement s about Erlotinib are true except?
A. Tyrosine kinase inhibitor
B. Food decreases its absorption
C. Rashes may occur
D. Used in non small cell lung carcinoma
Correct answer : B. Food decreases its absorption
Q31
All of the following statements about Selective Estrogen Receptor
Downregulator (SERD), Fulvestrant are true, Except
A. It is a selective estrogen antagonist
B. Used in the treatment of breast cancer
C. Slower acting, safer and less effective than SERM
D. May be administered as once a month dose
Correct answer : C. Slower acting, safer and less effective than SERM
Q32
All of the following statements about Ranolazine are true, except:
A. Piperazine derived antianginal agent
B. May be used as ?rst line agent in chronic angina
C. May improve Glycemic control
D. Hypotension is an established adverse effect
Correct answer : D. Hypotension is an established adverse effect
Q33
All of the following statements about meglitinides are true, except:
A. Act by stimulating insulin release
B. Decrease Postprandial Hyperglycemia
C. Hypoglycemia is less common than with sulfonylureas
D. Act by decreasing insulin resistance
Correct answer : D. Act by decreasing insulin resistance
Q34
lntegrase inhibitors approved for HIV is:
A. Raltegravir
B. lndinavir
C. Lopinavir
D. Elvitegravir
Correct answer : A. Raltegravir
Q35
Amphotericin B treatment mandates the monitoring of which of the
following electrolytes:
A. Na+
B. Ca2+
C. K+
D. Mg2+
Correct answer : C. K+
Q36
Prolonged treatment with INH leads to de?ciency of
A. Pyridoxine
B. Thiamine
C. Pantothenic acid
D. Niacin
Correct answer : A. Pyridoxine
Q37
A patient who was given primaquine develops dark coloured urine one day
after administration of the drug. The likely diagnosis is
A. Glucose-6-phosphate dehydrogenase deficiency
B. Glucose-6- phosphatase deficiency
C. Galactose-6-phosphate dehydrogenase de?ciency
D. Galactose-6-phosphatase deficiency
Correct answer : A. Glucose-6-phosphate dehydrogenase deficiency
Q38
Which of the following agents is not associated with Hyperthermia
A. Amphetamines
B. MAO inhibitors
C. Atropine
D. Alcohol
Correct answer : D. Alcohol
Q39
All of the following statements about serotonin syndrome are true,
except:
A. lt is not an idiosyncratic reaction
B. Can be caused by SSRI
C. Dantrolene is the drug of choice
D. Associated with hyperthermia and hypertension
Correct answer : C. Dantrolene is the drug of choice
Q40
Which of the following drug is most commonly used world wide in
maintenance doses for opioid dependence
A. Naltrexone
B. Methadone
C. lmipramine
D. Disul?ram
Correct answer : B. Methadone
Q41
BAL is useful in treating poisoning due to all except?
A. Lead
B. Organic mercury
C. Cadmium
D. Arsenic
Correct answer : C. Cadmium
Q42
Which of the following statements is not true about Tacrolimus?
A. It is macrolide Antibiotic
B. lt is indicated for the prophylaxis of organ transplant rejection
C. Glucose intolerance is a well Recognized side effect
D. It can be safely administered with any Nephrotoxic drug
B. Metoclopramide
C. Cisapride
D. Omeprazole
Correct answer : C. Cisapride
Q55
All the following statements regarding interactions of levodopa are
correct except:
A. In Parkinsonism, phenothiazines reduce its efficacy
B. It is a prodrug
C. Pyridoxine reduces effect of levodopa in parkinsonism
D. Domperidone blocks levodopa induced emesis and its therapeutic
potential
Correct answer : D. Domperidone blocks levodopa induced emesis and its
therapeutic potential
Q56
A patient of peptic ulcer was prescribed ranitidine and
morning hours. Why is this combination incorrect:
A. Ranitidine combines with sucralfate and prevents its
B. Combination of these two drugs produces serious side
agranulacytosis
C. Ranitidine decreases the gastric pH so sucralfate is
D. Sucralfate inhibits absorption of ranitidine
sucralfate in the
action
effects like
not able to act
Q60
All of the following are advantages of using Raloxifene over estrogen in
post menopasual women except?
A. Reduces fracture rates
B. Avoids Endometrial hyperplasia
C. Reduces incidence of venous thrombosis
D. No increase in incidence of breast carcinomas
Correct answer : C. Reduces incidence of venous thrombosis
Q61
All of the following Anticancer agents cause bone marrow depression
except?
A. Chlorambucil
B. Daunorubicin
C. Doxorubicin
D. Flutamide
Correct answer : D. Flutamide
Q62
All of the following statements about an alpha-glucosidase inhibitor are
true except:
A. Reduces intestinal absorbtion of carbohydrates
B. Effective in both type l & 2 diabetes
C. Hypoglycemia is a common & serious side effect
D. Can be used with other oral Hypoglycemic drugs
Correct answer : C. Hypoglycemia is a common & serious side effect
Q63
Which one of the following statements about biguanides is not true?
A. Dont stimulate insulin Release
B. Decrease hepatic glucose production
C. Renal Dysfunction is not a contraindication for their use
D. Can be combined with sulfonylureas
Correct answer : C. Renal Dysfunction is not a contraindication for their
use
Q64
Sympathomimetic drugs are useful in the therapy of all of the following
conditions except?
A. Acute decompensated heart failure
B. Hypotension
C. Hypertension
D. Erectile dysfunction
Correct answer : D. Erectile dysfunction
Q65
In which of the following phases of clinical trial of drug, ethical
clearance is not required?
A. Phase I
B. Phase II
C. Phase III
D. Phase IV
Correct answer : D. Phase IV
Q66
A highly ionized drug :
A. Is excreted mainly by the kidneys
B. Corsses the placental barrier easily
C. Is well absorbed from the intestine
D. Is highly protein bound
Correct answer : A. Is excreted mainly by the kidneys
Q67
A young pregnant woman presents with fulminant hepatic failure. The most
likely aetiological agent is:
A. Hepatitis B virus
B. Hepatitis C virus
C. Hepatitis E virus
D. Hepatitis A virus
Correct answer : C. Hepatitis E virus
Q68
Regarding methanol poisoning
Assertion: Administration of ethanol is one of the treatment modalities
Reason: Ethanol inhibits alcohol dehydrogenase
A) Both Assertion and Reason are true, and Reason is the correct
explanation for the Assertion
B) Both Assertion and Reason are true, and Reason is not the correct
explanation for the Assertion
C) Assertion is true, but Reason is false
D) Assertion is false, but Reason is true
Q69
Safest pain killer that can be administered in renal failure patients?
A. Nimesulide
B. Sulindac
C. Etoricoxib
D. Mefenamic Acid
Q70
Etanercept acts by one of the following mechanisms:
A. By blocking tumor necrosis factor
B. By blocking bradykinin synthesis
C. By inhibiting cyclo-oxygenase-2
D. By blocking lipoxygenase
Correct answer : A. By blocking tumor necrosis factor
Q71
Nevirapine is a
A. Protease inhibitor
B. Nucleoside reverse transcriptase inhibitor
C. Non-nucleoside reverse transcriptase inhibitor
D. Fusion inhibitor
Correct answer : C. Non-nucleoside reverse transcriptase inhibitor
Q72
Which one of the following is used in therapy of Toxoplasmosis?
A. Artensenuate
B. Thiacetazone
C. Ciprofloxacin
D. Pyrimethamine
Correct answer : D. Pyrimethamine
Q73
Which one of the following is best associated with Lumefantrine?
A. Antimycobacterial
B. Antifungal
C. Antimalarial
D. Antiamoebic
Correct answer : C. Antimalarial
Q74
The group of antibiotics which possess additional anti-inflammatory and
immunomodulatory activity is:
A. Tetracyclines
B. Polypeptide antibiotics
C. Fluoroquinolones
D. Macrolides
Correct answer : D. Macrolides
Q75
One of the following is not penicillinase susceptible:
A. Amoxicillin
B. Penicillin G
C. Piperacillin
D. Cloxacillin
Correct answer : D. Cloxacillin
Q76
All of the following are topically used sulphonamides except:
A. Sulphacetamide
B. Sulphadiazine
C. Silver sulphadiazine
D. Mafenide
Correct answer : B. Sulphadiazine
Q77
All of the following are hallucinogens, except:
A. LSD
B. Phencyclidine
C. Mescaline
D. Methylphenidate
Correct answer : D. Methylphenidate
Q78
Inverse agonist of benzodiazepine receptor is:
A. Phenobarbitone
B. Flumazenil
C. Beta-carboline
D. Gabapentin
Correct answer : C. Beta-carboline
Q79
C. Sodium citrate
D. Atropine
Correct answer : B. Metoclopramide
Q86
Which one of the following drugs increases gastro-intestinal motility?
A. Glycopyrrolate
B, Atropine
C. Neostigmine
D. Fentanyl
Correct answer : C. Neostigmine
Q87
With which of the following theophylline has an antagonistic interaction?
A. Histamine receptors
B. Bradykinin receptors
C. Adenosine receptors
D. lmidazoline receptors
Correct answer : C. Adenosine receptors
Q88
Which one of the following is true of adrenal suppression due to steroid
therapy?
A. It is not associated with atrophy of the adrenal glands
B. It does not occur in patients receiving inhaled steroids
C. It should be expected in anyone receiving > 5mg Prednisolone daily
D. Following cessation, the stress response normalizes after 8 weeks
Correct answer : C. It should be expected in anyone receiving > 5mg
Prednisolone daily
Q89
All of the following hormones have cell surface receptors except:
A. Adrenaline
B. Growth Hormone
C. Insulin
D. Thyroxine
Correct answer : D. Thyroxine
Q90
A highly ionized drug:
A. Is excreted mainly by the kidney
B. Can cross the placental barrier easily
C. ls well absorbed from the intestine
D. Accumulates in the cellular lipids
Correct answer : A. Is excreted mainly by the kidney
Q91
All of the following are part of the treatment of lithium toxicity,
except:
A. Treating dehydration
B. Ingestion of polystyrene sulfonate
C. Hemodialysis
D. Using an antagonist
B. Gabapentin
C. Phenobarbitone
D. Primidone
Correct answer : B. Gabapentin
Q105
Concomitant administration of clonazepam with which of the following
antiepileptic drug can precipitate absence status?
A. Sodium valproate
B. Phenobarbitone
C. Carbamazepine
D. Phenytoin
Correct answer : A. Sodium valproate
Q106
Ethosuximide is used in the treatment of
A. Tonic-clonic seizure
B. Absence seizure
C. Myoclonic seizure
D. Simple partial seizure
Correct answer :B. Absence seizure
Q107
The following statements regarding benzodiazepines are true except:
A. Binds to both GABA A and GABA B receptors
B. They have active metabolites
C. Decreases nocturnal gastric secretion in human beings
D. Extensively metabolized by CYP enzymes
Correct answer :A. Binds to both GABA A and GABA B receptors
Q108
The following are the benzodiazepines of choice in elderly and those with
liver disease, except:
A. Lorazepam
B. Oxazepam
C. Temazepam
D. Diazepam
Correct answer : D. Diazepam
Q109
The loading dose of Aminophylline is:
a) 50-75 mg/kg
b) 0.5-1.0 mg/ kg
c) 2.0-3.5 mg/kg
d) 5-6 mg/kg
Correct answer : d) 5-6 mg/kg
Q110
The drug imatinib acts by inhibition of:
a) Tyrosine kinase
b) Glutathione reductase
c) Thymidylate synthase
d) Protein kinase
e) Ethambutol
d) Pyrazinamide
Correct answer : b) INH
Q124
Which antiarrhythmic is not class Ic agent
a) Propafenone
b) Tocainide
c) Flecainide
d) Encainide
Correct answer : b) Tocainide
Q125
Which NSAID undergoes enterohepatic circulation
a) Phenylbutazone
b) Aspirin
c) lbuprofen
d) Piroxicam
Correct answer : d) Piroxicam
Q126
Long acting B2 agonists
a) Orciprenaline
b) Salmeterol
e) Albuterol
d) Pirbuterol
Correct answer : b) Salmeterol
Q127
Which of the following drugs dosage interval should be maximum in a
patient with creatinine clearance less than 10ml/min
a) Amikacin
b) Rifampicin
c) Vancomycin
d) Amphotericin B
Correct answer : c) Vancomycin (It is given once in 72 hours when
creatinine clearance is less than 10ml/min)
Q128
Which antibiotic acts by inhibiting cell wall synthesis
a) Cefepime
b) Lomefloxacin
C) Erythromycin
d) Tetracycline
Correct answer : a) Cefepime
Q129
Denosumab, a monoclonal antibody against RANKL receptor is used in the
treatment of
a) Rheumatoid arthritis
b) Osteoporosis
c) Osteoarthritis
d) SLE
c) Amphetamine
d) Cocaine
Correct answer : a) Methadone
Q137
Imatinib used in CML acts by
a) inhibiting Bcr/abl translocation via tyrosine kinase
b) Blocking the action of P-glycoprotein
c) Competitive inhibition of ATP binding site of ABL kinase
d) C-kit kinase inhibition
Correct answer : c) Competitive inhibition of ATP binding site of ABL
kinase
Q138
Drugs which increase Nitric Oxide are all except
a) Glycerine trinitrate
b) Hydralazine
c) Sodium Nitroprusside
d) Fenoldopam
Correct answer : d) Fenoldopam
Q139
Antihypertensive not contraindicated in pregnancy
a) Spironolactone
b) Labetalol
c) Sodium Nitroprusside
d) ACE inhibitor
Correct answer : b) Labetalol
Q140
Hypertension is seen with all except
a) Erythropoietin
b) Cyclosporine
c) NSAID
d) Levodopa
Correct answer : d) Levodopa
Q141
Which is an antimetabolite
a) Cyclosporine
b) Methotrexate
c) Etoposide
d) Vinblastine
Correct answer : b) Methotrexate
Q142
All are antiemetics except :
a) Domperidone
b) Ondensetron
c) Phenazocine
d) Cyclizine
Correct answer : c) Phenazocine
Q143
Bone marrow aplasia is seen with all except
a) Methicillin
b) Chloramphenicol
c) Alpha methyl hydantoin
d) Phenylbutazone
Correct answer : a) Methicillin
Q144
Carbimazole is associated with all except :
a) Choanal atresia
b) Cleft lip and cleft palate
c) Scalp defect
d) Neck swelling
Correct answer : b) Cleft lip and cleft palate
Q145
All are endogenous catecholamines except :
a) Epinephrine
b) Norepinephrine
c) Dopamine
d) Dobutamine
Correct answer : d) Dobutamine
Q146
Impotence is most commonly caused by which antihypertensive agent
a) Calcium channel blocker
b) ACE inhibitors
c) AT1 receptor antagonist
d) Beta blockers
Correct answer : d) Beta blockers
Q147
Gynaecomastia is caused by
a) Clorniphene citrate
b) Tamoxifen
c) Spironolactone
d) Testosterone
Correct answer : c) Spironolactone
Q148
Filgrastim is used in treatment of:
A. Anemia
B. Neutropenia
C. Malaria
D. Filariasis
Correct answer : B. Neutropenia
Q149
Methotrexate is used in high doses in:
A. Osteosarcoma
B. Retinoblastoma
C. Rhabdomyosarcoma
D. Ewings sarcoma
A.
B.
C.
D.
Abciximab
Clopidogrel
Tirofiban
Epitifibatide
D. Labetalol
Correct answer : Betaxolol, It is a selective beta blocker with
additional actions