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Periodic Table
Answer Sheet
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MCAT
Practice Test 5R
Physical Sciences
Time: 100 minutes
Questions: 1-77
Most questions in the Physical Sciences test are organized into groups, each containing a descriptive
passage. After studying the passage, select the one best answer to each question in the group. Some questions are
not based on a descriptive passage and are also independent of each other. If you are not certain of an answer,
eliminate the alternatives that you know to be incorrect and then select an answer from the remaining alternatives.
Indicate your selected answer by marking the corresponding answer on your answer sheet. A periodic table is
provided for your use. You may consult it whenever you wish.
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the MCAT hold the copyrights to the content of this Practice Test. Therefore, there can be no sharing or
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He
4.0
10
1.0
3
Li
Be
Ne
6.9
9.0
10.8
12.0
14.0
16.0
19.0
20.2
11
12
13
14
15
16
17
18
Na
Mg
Al
Si
Cl
Ar
23.0
24.3
27.0
28.1
31.0
32.1
35.5
39.9
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
Ca
Sc
Ti
Cr
Mn
Fe
Co
Ni
Cu
Zn
Ga
Ge
As
Se
Br
Kr
39.1
37
40.1
38
45.0
39
47.9
40
50.9
41
52.0
42
54.9
43
55.8
44
58.9
45
58.7
46
63.5
47
65.4
48
69.7
49
72.6
50
74.9
51
79.0
52
79.9
53
83.8
54
Rb
Sr
Zr
Nb
Mo
Tc
Ru
Rh
Pd
Ag
Cd
In
Sn
Sb
Te
Xe
85.5
55
87.6
56
88.9
57
91.2
72
92.9
73
95.9
74
(98)
75
101.1
76
102.9
77
106.4
78
107.9
79
112.4
80
114.8
81
118.7
82
121.8
83
127.6
84
126.9
85
131.3
86
Cs
Ba
La*
Hf
Ta
Re
Os
Ir
Pt
Au
Hg
Tl
Pb
Bi
Po
At
Rn
132.9
87
137.3
88
138.9
89
178.5
104
180.9
105
183.9
106
186.2
107
190.2
108
192.2
109
195.1
197.0
200.6
204.4
207.2
209.0
(209)
(210)
(222)
Fr
Ra
Ac
Unq
Unp
Unh
Uns
Uno
Une
(223)
(226)
(227)
(261)
(262)
58
(263)
59
(262)
60
(265)
61
(267)
62
63
64
65
66
67
68
69
70
71
Ce
Pr
Nd
Pm
Sm
Eu
Gd
Tb
Dy
Ho
Er
Tm
Yb
Lu
140.1
90
140.9
91
144.2
92
(145)
93
150.4
94
152.0
95
157.3
96
158.9
97
162.5
98
164.9
99
167.3
100
168.9
101
173.0
102
175.0
103
Th
Pa
Np
Pu
Am
Cm
Bk
Cf
Es
Fm
Md
No
Lr
232.0
(231)
238.0
(237)
(244)
(243)
(247)
(247)
(251)
(252)
(257)
(258)
(259)
(260)
Passage I
Ammonia can be prepared by the reversible reaction
between H2 and N2 in the presence of a mixture of FeO
and Al2K2O4 (Reaction 1) under a variety of conditions
(Table 1).
Reaction 1
Table 1 Equilibrium Concentrations of NH3(g) at
Several Temperatures and Pressures
Equilibrium concentration of NH3(g)
Pressure
(% by volume)
(atm)
at 200C at 400C at 600C at 800C
1
15.3
0.44
0.05
0.01
100
80.6
25.1
4.47
1.15
200
85.8
36.3
8.25
2.24
1,000
98.3
80.0
31.5
B)
Mg3N2(s) + H2O(l)
Mg(OH)2(s) + NH3(g)
Reaction 2
Ammonia and ammonium salts are used as commercial
fertilizers. Ammonium salts are prepared by reacting
NH3 with HX (an acid) as shown below (Reaction 3).
NH3(g) + HX(aq)
NH4X(s)
Reaction 3
C)
D)
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Passage II
A large amount of energy is released when the nucleus
of an atom disintegrates. Nuclear fission of 1 kg of
U produces approximately 8.0 1013 J, an amount of
energy equal to that produced by burning 2.3 106 kg
of coal. A simple model of nuclear disintegration can
be used to explain the source of this large amount of
energy.
The nucleus of a U atom contains 92 protons and
146 neutrons in a sphere with a radius of
approximately 7.6 1015 m. There is a large repulsive
force between the positive charges in the nucleus. This
force is balanced by a short-range attractive force, the
strong nuclear force. By using a simple model,
calculations can be done to find the amount of energy
released when a uranium atom fissions. The model
assumes that the uranium nucleus disintegrates into
two spherical fragments, as shown in Figure 1.
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B)
C)
D)
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Passage III
Ozone (O3) is formed in the upper atmosphere by
reactions 1 and 2.
O+O
Reaction 2: O + O O
Reaction 1: O2
F C + Cl
Reaction 4: Cl + O ClO + O
Reaction 5: ClO + O Cl + O
Reaction 3: F3CCl
B)
C)
D)
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3O
A) 33.8 J/(molK)
B) 33.8 J/(molK)
C) 137.4 J/(molK)
D) 137.4 J/(molK)
18. From reactions 35, what can be determined about
the relative concentrations of CFCs and O2?
A) One equivalent of CFC is required to produce one
equivalent of O2.
B) One equivalent of CFC is required to produce two
equivalents of O2.
C) A catalytic amount of CFC can produce much O2.
D) The CFC is produced by a catalytic amount of O2.
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10
Passage IV
Fertilizers are substances added to the soil to improve
plant growth and productivity. Commonly used
fertilizers contain ionic salts of N, P, and K. Because
of the complexity of soil chemistry, it is often difficult
to predict how soil pH will be affected by the addition
of a fertilizer.
Ionic salts used as fertilizers can generally be classified
chemically as either acidic or basic. Ammonium
dihydrogen phosphate (NH4H2PO4), a commonly used
fertilizer, can alter soil pH according to Equation 1.
2 NH4H2PO4(s)
2 NH4+(aq) + H2PO4(aq) + HPO42(aq) + H+(aq)
Equation 1
Alternatively, the fertilizer ammonium monohydrogen
phosphate [(NH4)2HPO4] can alter soil pH according to
Equation 2.
2 (NH4)2HPO4(s) + H2O(l)
4 NH4+(aq) + HPO42(aq) + H2PO4(aq) + OH(aq)
Equation 2
Equation 3
The nitrate ions are taken up by plants and converted
first to nitrite ions, NO2, then to ammonia for amino
acid synthesis in the plant.
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11
24.
Na2CO3 + HCl
CO
+ H2O + NaCl
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12
Passage V
A chemist is studying the catalytic effect of the
enzyme polynucleotide phosphorylase (PNP) on the
polymerization of cytosine 3',5'-diphosphate (CDP).
PNP cleaves nucleoside diphosphates with the release
of a phosphate species, and the addition of a trace
amount of magnesium ion ensures that the catalyst is
active. Equation 1 shows a polymerization reaction in
which a single polymer macromolecule is made from
CDP.
Equation 1
In practice, the reaction shown in Equation 1 occurs
many times, yielding a product composed of many
polymeric strands.
Experiment 1
The chemist dissolves 16 mmol CDP in 1 L of an
aqueous solution containing PNP and Mg2+ and buffers
the solution at pH 8.7. The chemist monitors the
reaction by measuring the amount of inorganic
phosphate produced. No reaction is detected for 30
min, then the reaction appears to proceed at a constant
rate until it stops with a final HPO42 concentration of
8 mM. The recovered polymer contains 7.5 mmol of
cytosine.
[(CP)n] [HPO42]n
[CDP]n
[(CP)n] [HPO42]
[CDP]n
[(CP)n] [HPO42]n
[CDP]
[CP] [HPO42]n
[CDP]n
Experiment 2
A) n[HPO42].
B) n2[HPO42].
C) (1/n)[HPO42].
D) (1/n2)[HPO42].
32. The pKa for the dissociation of H2PO4 to HPO42
is 6.7. What is the initial ratio of
[HPO42]:[H2PO4] in the buffer solution of
Experiment 1?
A) 1:1
B) 2:1
C) 100:1
D) 200:1
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13
Passage VI
Carbon dating is a common method for estimating the
age of artifacts found by archaeologists. The principle
of radioactive dating is based on knowledge of the
characteristics of the 14C isotope, which is commonly
found in most handmade objects. This isotope is
unstable and experiences spontaneous beta decay with
a half-life of approximately 6000 years. Archaeologists
need only a single radioactive measurement from a
found object to estimate the age of the object.
Scintillation detectors are often used for measurement
of radioactive decay. A scintillator is a substance that
produces light as a result of the de-excitation of atoms.
The excitation is caused by the absorption of energy, in
this case from incident beta radiation. A scintillating
material is attached to a photomultiplier tube that
collects the light and converts it into electrical pulses,
which are measured and counted. The electrical pulses
indicate the energy of the radiation produced by the
object being measured and the rate at which the decay
occurs.
The mass of the beta particle is 9 1031 kg. The
velocity of electromagnetic radiation in vacuum is 3
108 m/s. Plancks constant is 6.6 1034 Js.
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14
Passage VII
A group of students performed two experiments to
study several transition metals.
Experiment 1
The students reacted four transition metals with
nonmetals and observed the products formed (Table 1).
Table 1 Products of Reacting Transition Metals with
Nonmetals
Transition
Metal
Ni
Cu
O2(g)
NiO
Cu2O,
CuO
ZnO
Ag2O
Zn
Ag
S(s)
NiS
Cu2S
ZnS
Ag2S
Nonmetal
Cl2(g)
Br2(l)
NiCl2
NiBr2
CuCl2
CuBr2
ZnCl2
AgCl
ZnBr2
AgBr
I2(s)
NiI2
CuI
ZnI2
AgI
Experiment 2
The students prepared solutions of 0.1 M X(NO3)n(aq),
where X represents a transition metal. Then they
prepared the following three reagents.
0.1 M NaCl(aq)
0.1 M (NH4)2C2O4(aq)
0.1 M Na2CO3(aq)
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15
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16
Passage VIII
A student performed an experiment to investigate
thermal and electrical properties of an iron wire. At
room temperature the wire had a length (L) of 4 m, a
diameter (D) of 4 104 m, and a mass (M) of 4 103
kg. The wire was connected in series with an ammeter,
a power supply, and a switch.
The student selected a voltage (V) and closed the
switch so current (I) flowed through the circuit, raising
the wires temperature (T). The values in Table 1 were
measured in five trials with different wire temperatures.
(Note: The initial value of R, the circuits resistance,
was measured at a temperature of 293 K with an
ohmmeter. The other values of R were calculated from
the values of V and I.)
Table 1 Data for Thermal and Electrical Properties of
Iron Wire
R
T
L
I
V
Trial
(K)
(m)
(A)
(V)
()
1
293
4.000
4.0
0
0
2
373
4.004
6.1
0.75
4.6
3
473
4.009
8.7
1.18
10
4
573
4.014
11.3
1.60
18
5
673
4.019
13.9
2.00
28
The change in wire length (L) is related to the change
in temperature (T) by the relationship L = LT,
where , the coefficient of thermal expansion, is a
constant. A similar relationship, D = DT, describes
how the diameter of a wire changes when it is heated.
The constant has the same value in both equations.
The energy radiated from a heated wire each second is
AT 4, where A is the surface area of the wire, and =
5.67 108 J/m2sK4 is the Stefan-Boltzmann constant.
B)
C)
D)
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17
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18
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19
Passage IX
A chemist reacted Substance X with various quantities
of Ti and then performed two experiments to study the
properties of the resulting samples. The samples
contained 0%, 1%, 3%, and 5% Ti (and were referred
to as XT-0, XT-1, XT-3, and XT-5, respectively.)
Experiment 1
The solubilities of the XTs were determined by adding
a fixed amount of each to two different solvents,
tetrahydrofuran (THF) and toluene (Figure 1). The
results are shown in Table 1.
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20
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21
Passage X
A 47-kg child with a 3-kg sled and a 54-kg child with a
6-kg toboggan slide down the ice-covered hill
illustrated in the figure below. Points A and B are at
the top and bottom of the hill, respectively, and are a
distance l apart along the slope. Between points A and
B the sled and rider slide free of friction, but the
toboggan and rider are opposed by a constant 60-N
frictional force. To the right of Point B the sled and
rider are opposed by a 50-N frictional force, and the
toboggan and rider are opposed by a 120-N frictional
force. (Note: Assume that air resistance is negligible.
Use g = 10 m/s2.)
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22
Passage XI
Lasers produce extremely coherent light due to the
long-term stability of the standing-wave pattern
established within a laser cavity. A standing-wave
pattern in a laser cavity is illustrated in the figure
below.
It is monochromatic.
It is coherent.
It is diffuse.
A) I only
B) I and II only
C) I and III only
D) II and III only
70. A gas laser has a cavity length of m and a
single oscillation frequency of 9.0 x 1014 Hz. What
is the cavity mode number?
A) 1.5 x 106
B) 2.0 x 106
C) 3.0 x 106
D) 6.0 x 106
71. A gas laser can oscillate simultaneously in two
adjacent cavity modes. This oscillation produces
beats; the beat frequency is b = (fm+1 fm) where
m+1 and m are the frequencies of the two cavity
modes. Which of the following is an expression
for the beat wavelength?
A)
(fm+1 fm)
c
B) c(fm+1 fm)
C)
1
c(fm+1 fm)
D)
c
(fm+1 fm)
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23
A) 1.0 m/s
B) 2.0 m/s
C) 4.0 m/s
D) 8.0 m/s
74. Which of the following will occur if the acidity of
a saturated solution of Ca(OH)2 is increased?
A) The Ksp will decrease and additional Ca(OH)2 will
dissolve.
B) The Ksp will be unchanged and additional Ca(OH)2
will dissolve.
C) The Ksp will decrease and additional Ca(OH)2 will
precipitate.
D) The Ksp will be unchanged and additional Ca(OH)2
will precipitate.
75. In a nearsighted individual, the image of a distant
object is focused:
A) in front of the retina, requiring divergent lens
correction.
B) in front of the retina, requiring convergent lens
correction.
C) behind the retina, requiring divergent lens
correction.
D) behind the retina, requiring convergent lens
correction.
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24
Verbal Reasoning
Time: 85 minutes
Questions: 78-137
There are nine passages in the complete Verbal Reasoning test. Each passage is followed by several
questions. After reading a passage, select the one best answer to each question. If you are not certain of an answer,
eliminate the alternatives that you know to be incorrect and then select an answer from the remaining
alternatives. Indicate your selected answer by marking the corresponding answer on your answer sheet.
This document has been encoded to link this download to your member account. The AAMC and its Section for
the MCAT hold the copyrights to the content of this Practice Test. Therefore, there can be no sharing or
reproduction of materials from the Practice Test in any form (electronic, voice, or other means). If there are any
questions about the use of the material in the Practice Test, please contact the MCAT Information Line (202828-0690).
Passage I
As the national government has reordered its economic
priorities, state and local governments have become
more innovative and active vis--vis their economies.
The characteristic that distinguishes state and local
economic development activity is competitiveness.
Nonnational governments are awash in competition for
economic development, primarily for a structural
reason: A fragmented federal system fosters
interjurisdictional competition. More that 82 percent of
influential local officials in Southeastern cities termed
the economic development environment very
competitive in a survey conducted in l986.
State and local governments have reacted to this
situation by taking actions intended to make
themselves more attractive to new and relocating
enterprises. If a business firm is unhappy with
conditions in a community, it may seek a new location,
and it is likely to find other communities waiting with
open arms. When the Mack Truck Company
announced its intention to relocate its manufacturing
facility from Allentown, Pennsylvania, it had an array
of communities from which to choose. To make
themselves more enticing, the beckoning jurisdictions
(and their state governments) offered a panoply of
incentives, including property tax abatements, belowcost land, infrastructure, and training programs for
potential employees. Mack Truck decided to relocate
to South Carolina.
Economic competition is most apparent when the
stakes are highthat is, when the location decision
will mean a substantial number of jobs, as in the case
of General Motors Saturn plant. State after state lined
up to offer General Motors generous packages of
financial incentives, promising an assortment of tax
breaks, access roads, water and sewer systems, and
employee training. The eventual winner was Tennessee.
There is a great deal of debate about the effect of
interjurisdictional competition. As we noted earlier,
incentives and concessions amount to a giveaway to
business. Critics claim that competition for economic
development is nothing more than the relocation of a
given amount of economic activity from one
community to another, with no overall increase in
national productivity. The solution, they argue, is
increased cooperation. However, this is elusive. For
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26
national government.
state government.
local government
A) I only
B) II only
C) I and II only
D) II and III only
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27
Passage II
Knowledge structures called memory schemas have
become very important in theories of human learning
and thinking. Schemas are organized knowledge
structures in memory that can be thought of as generic
concepts representing objects, persons, situations,
events, sequences of events, actions, or sequences of
actions.
A memory schema is activated when information
similar to its content is processed by the cognitive
system. Once activated, the schema influences the
processing of the new information and provides a
mental context for it. If the information is similar
enough to the content of the schema, then it is judged
an instance of what the schema represents. The schema
is thus instantiated by the new information. For
example, if a person sees only an eye and a nose in a
picture, with other facial features in shadow and not
visible, the person may infer on the basis of this partial
information that he or she should look for a face. This
example assumes, of course, that the eye and nose have
the correct orientation and the correct relative position.
There is a special type of schema called a script that
not only aids in comprehending and remembering
information but also helps guide behavior. For
example, when a person is eating in a restaurant, the
restaurant script activated in memory enables the
person not only to expect certain events (such as being
shown a table and being approached by a waiter) but
also initiates behavior (such as ordering and paying).
If a person reading a passage comes upon the sentence
John was hungry, so he entered a restaurant, the
restaurant script is activated in memory. The advantage
of having this active script available to the reader is
that it provides general information about restaurants.
However, specific information about this particular
restaurant event must be selected from the passage as
an instance of the script. If the next sentence is John
sat down near the door and gave his order to Paul,
then the generic script allows the reader to infer that
John sat down at a table in a particular location and
gave his order to someone named Paul who was a
waiter. This process is called slot filling because
information specific to the restaurant event being read
is stored in memory as values for the particular actions,
roles, and props involved in the restaurant script. The
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28
A) I only
B) II only
C) I and II only
D) I, II, and III
87. If several readers were to recall conflicting details
from the same literary work, this situation would
best support the assertion that:
A) inferences are made independently of schemas.
B) scripts cannot be partially activated.
C) schemas are instantiated subconsciously.
D) recall errors are a normal feature of schema-based
comprehension.
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29
A) I only
B) II only
C) I and II only
D) II and III only
93. The contention that the schema influences the
processing of the new information and provides a
mental context for it can most justifiably be
interpreted as support for the idea that:
A) understanding requires concentrated study.
B) experience supplies a framework for learning.
C) meaning can arise only after all the facts are
acquired.
D) clear thinking requires a conscious exercise of
memory.
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30
Passage III
Research traditions and theories can encounter serious
cognitive difficulties if they are incompatible with
certain broader systems of belief within a given culture.
Such incompatibilities constitute conceptual problems
that may seriously challenge the acceptability of the
theory. But it may equally well happen that a highly
successful research tradition will lead to the
abandonment of that world view which is incompatible
with it and to the elaboration of a new world view
compatible with the research tradition. Indeed, it is in
precisely this manner that many radically new
scientific systems eventually come to be canonized
as part of our collective common sense.
In the seventeenth and eighteenth centuries, for
instance, the new research traditions of Descartes and
Newton went violently counter to many of the most
cherished beliefs of the age on such questions as
humanitys place in Nature, the history and extent of
the cosmos, and more generally, the nature of physical
processes. Everyone at the time acknowledged the
existence of these conceptual problems. They were
eventually resolved, not by modifying the offending
research traditions to bring them in line with more
traditional world views, but rather by forging a new
world view which could be reconciled with the
scientific research traditions. A similar process of
readjustment occurred in response to the Darwinian
and Marxist research traditions in the late nineteenth
century; in each case, the core, nonscientific beliefs
of reflective people were eventually modified to bring
them in line with highly successful scientific systems.
But it would be a mistake to assume that world views
always crumble in the face of new scientific research
traditions which challenge them. To the contrary, they
often exhibit a remarkable resilience which belies the
(positivistic) tendency to dismiss them as mere fluff.
The history of science, both recent and distant, is
replete with cases in which world views have not
evaporated in the face of scientific theories which
challenged them. In our own time, for instance, neither
quantum mechanics nor behavioristic psychology has
shifted most peoples beliefs about the world or
themselves. Contrary to quantum mechanics, most
people still conceive of the world as being populated
by substantial objects, with fixed and precise
properties; contrary to behaviorism, most people still
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31
II.
III.
A) I only
B) III only
C) I and II only
D) I and III only
99. The author probably mentions that most people
talk as if inner mental states existed in order:
A) to demonstrate the weakness of some scientific
theories.
B) to provide an example of the application of natural
law to human behavior.
C) to illustrate the persistence of beliefs that conflict
with scientific theories.
D) to support the claim that behaviorism is a very new
research tradition.
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32
Passage IV
Approximately 65 million years ago, at the boundary
between the Cretaceous and Tertiary geological
periods (the K-T boundary), there was a large-scale
and rapid extinction of plants and animals, including
the dinosaurs. The discovery of high levels of the
element iridium in rocks laid down at this time led to
the proposal that an asteroid or a comet struck Earth,
leading to the extinctions. This scenario proposes that
the impact of the interplanetary object filled Earths
atmosphere with dust and smoke, blocking out sunlight
and lowering temperatures. The resulting winter
would have had dire ecological consequences,
including slowing plant growth. However, in the case
of the K-T boundary, some scientists have expressed
doubt that the dust could have made Earth cold enough
for a long enough period to cause the massive
extinctions observed.
These doubts have led to a search for other possibly
disastrous atmospheric effects of a collision between a
celestial object and Earth. One might involve
sedimentary rocks rich in carbonates, which are found
in shallow ocean beds or on dry land that was once
under the ocean. If an asteroid with a radius of 50 km
struck a 4-km thick carbonate layer, there would be a
significant release of carbon dioxide (CO2) into the
atmosphere, enough to raise the atmospheric
concentration of CO2 about a hundredfold.
When sunlight hits Earth, a significant portion of its
heat is radiated out into the atmosphere. Atmospheric
CO2 absorbs the heat that is radiated from Earth and
radiates it back to Earth. This warming is called the
greenhouse effect. Over the past century, atmospheric
CO2 has increased, primarily due to the burning of
fossil fuels such as coal and oil. Projections of future
fuel usage have prompted many experts to be
concerned about further increases in atmospheric CO2
because these increases could lead to global warming
and significant climatic changes. The temperature
increases projected by some for the next century are on
the order of 2C to 4C. Atmospheric modeling
indicates that such increases could lead to, among
other effects, a partial melting of the polar ice caps,
causing flooding of low-lying coastal areas.
33
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34
Passage V
From 1890, when he was nine, Picassos family saved
virtually every scrap of paper on which he drew.
Harbingers of Picassos later genius appear in
fragmented and distorted aspects of form and scale,
depictions garlanded by numerical and alphabetical
symbols, a proliferation of trompe loeil, visual puns,
outrageous caricatures, incongruous juxtapositions,
and the like. We do not know whether Picasso
consciously thought back to these graphic experiments
when, two decades later, he and Georges Braque were
inventing cubism, but at least at an unconscious level,
Picasso could tap this reservoir of youthful
experimentation.
The standard story told of Picasso is that his
precocious talent enabled him to surpass, without
effort, all other artists in his milieu. It is worth
considering Picassos own opinion that what is often
considered early genius is actually the navet of
childhood. It disappears at a certain age without
leaving traces. It is possible that a young child who
shows unusual flair will one day become an artist, but
he or she will have to begin again from the beginning.
I did not have this genius. For example, my first
drawings could not have been hung in a display of
childrens work. These pictures lacked
childlikeness. . . . At a youthful age I painted in a quite
academic way, so literal and precise that I am shocked
today. At an exhibition of childrens art, Picasso once
quipped, When I was their age, I could draw like
Raphael, but it has taken me a whole lifetime to learn
to draw like them.
In such remarks, Picasso exalted childrens
productions but also distanced his youthful self from
the romantic view of artistic talent. It is true that the
works preserved by Picassos family support the notion
of Picasso as an aspiring academic painter (as his
father was) and not as a charming naf. However, we
lack drawings by Picasso from his first eight years and
so cannot determine the resemblance of his earliest
efforts to those of other children. Moreover, his
youthful caprices and marginalia may have been as
crucial in his artistic development as his formally
conceived early paintings. My own conclusion is that
Picassos output during the first decade of his life was
unusually skilled rather than frankly precocious but
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Passage VI
One of the hottest topics in anthropology today centers
around the place of the mysterious Neandertals on the
human family tree. These people lived at the juncture
between the demise of Homo erectus and the advent of
Homo sapiens sapiens, our own species.
What role the Neandertals played in this transition has
been the subject of long and contentious debate among
anthropologists. Call them Homo sapiens
neanderthalensis and acknowledge them as direct
ancestors of modern humans? Or type them as Homo
neanderthalensis and more distant relatives, members
of a separate species outside our direct ancestry?
If someone were to meet a Neandertal on the New
York subway, he or she would be struck by the size
and protrusion of the nose, the prominent ridges above
the eyes, and the distinct absence of a chin. In addition,
the forehead was much flatter and the skull longer, and
although not readily apparent to fellow passengers, the
bones of the skull would be much thicker than those in
modern humans. What was inside that long, low
cranium is the key to what it was to be a Neandertal. If
quantity was the only measure, then the Neandertals
apparent mental powers were impressive, because the
average brain size was larger than a modern
humansabout 1,400 cc as compared with 1,360 cc.
Some clues to their potential humanness do exist.
For the first time in history, the Neandertal people
performed ritual burialsa uniquely human activity.
At the site of Le Moustier in France, the body of a
Neandertal teenager was apparently lowered into a pit,
where he was placed on his right side, his head resting
on his forearm, as if asleep. Around the body were
scattered the bones of a wild cow. Some prehistorians
speculate that these bones were covered with meat at
the time of the boys burial and were included as
sustenance for his journey to the next world.
The evolution of the Neandertals was a gradual affair,
with roots going back at least 200,000 and maybe even
300,000 years. By 130,000 years ago, they were well
established. And by the end of that interglacial respite,
which ended 70,000 years ago, the exaggerated
features of the classic Neandertals were well set. For
the next 35,000 years or sountil they finally
disappearedNeandertals were truly people of the Ice
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Passage VII
Rita Doves Pulitzer-Prize-winning volume of poems,
Thomas and Beulah, is divided into two almost equal
parts called Mandolin and Canary in Bloom. The
collection presents not only the single most important
events and the resultant mind-sets in the separate lives
of Thomas and Beulah but also the significant events
of their shared lives from their different perspectives.
The Event (from Mandolin) presents the night
when Thomas and his friend Lem, both drunk, leaned
on the rail of a river boat. Thomas challenged Lem to
swim to an island, resulting in Lems death. Taking in
Wash (from Canary in Bloom) presents Beulahs
memory of the tension between her mother and father.
The shaping events of Thomass and Beulahs lives
create or contribute to psychological mind-sets
represented, on the one hand, by a mandolin, ships, and
water, and on the other, by a silk handkerchief, the
Eiffel Tower, an unusual flower, and a ballerina music
box. The mandolin represents both Thomass carefree
days with Lem and the guilt suffered because of his
death. In Variation on Pain, the one pierced cry of
the strings of the mandolin are identified both with
music and guilt (Sound quivered like a rope stretched
clear to land, tensed and brimming, a man gurgling air)
and with the strings Thomas used after piercing his
ears, which in turn were also connected with his guilt
(Since what hed been through, he was always jiving,
gold hoop from the right ear jiggling and a glass stud,
bright blue, in his left).
The references to ships and water are linked not only
to Thomass guilt but also to his sense of a lack of
freedom even on happy occasions, his disappointments,
and ultimately, the escape from ordinary life that he
has always desiredbut not in the form he has wanted.
After Lems death, Thomas eventually lands on the
dingy beach of a man-made lake. When Thomas and
Beulah marry, the parlor is festooned like a ship;
later, he has raised a mast and tied himself to it. Still
later, he is drowning in his disappointment in being
too frail for combat. His fatal heart attack is the
river he had to swim; he has the sensation that his
chest was filling with water, and he becomes a pod
set to sea.
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Passage VIII
The biosphere, all organisms combined, makes up only
about one part in ten billion of Earths mass. Yet life
has divided into millions of species, each playing a
unique role in relation to the whole.
The hallmark of life is this: a struggle among an
immense variety of organisms weighing next to
nothing for a vanishingly small amount of energy. Life
operates on only ten percent of the suns energy
reaching Earths surface, that portion fixed by the
photosynthesis of green plants. The free energy is then
sharply discounted as it passes through the food webs
from one organism to the next; very roughly ten
percent passes to the caterpillars and other herbivores
that eat the plants and bacteria, ten percent of that (or
one percent of the original) to the spiders and other
low-level carnivores that eat the herbivores, ten
percent of the residue to the warblers and other middlelevel carnivores that eat the low-level carnivores, and
so on upward to the top carnivores, which are
consumed by no one except parasites and scavengers.
Top carnivores, including eagles, tigers, and great
white sharks, live on such a small portion of lifes
available energy as always to skirt the edge of
extinction.
A great deal can be learned quickly about biological
diversity by noticing that species in the food web are
arranged into two hierarchies. The first is the energy
pyramid, a straightforward consequence of the law of
diminishing energy flow. The second pyramid is
composed of biomass, the weight of organisms. By far
the largest part of the physical bulk of the living world
is contained in plants. The second largest amount
belongs to the scavengers and other decomposers, from
bacteria to fungi and termites, which together extract
the last bit of fixed energy from dead tissue and waste
at every level in the food web. Each level above the
plants diminishes thereafter in biomass until you come
to the top carnivores, which are so scarce that the very
sight of one in the wild is memorable. No one looks
twice at a sparrow or squirrel, but a peregrine falcon or
mountain lion is a lifetime experience.
A) I only
B) III only
C) I and II only
D) II and III only
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Passage IX
Some people may have no friendships of a high level
of moral excellence. And, as Aristotle recognized,
some people may actually be incapable of such
friendships. A truly selfish person could not have
friends in the fullest sense. If someone were genuinely
able to care for another person for the others own sake,
if someone were able to give much of him- or herself
to the other freely and for the others own sake, then he
or she would not be selfish.
It is true that selfish people can be very attached to one
or another persone.g., a spouse or friend. But it
seems that such a friendship could not be a friendship
of the most morally excellent kind. The attachment or
friendship would be too grounded in self-centered
considerations. Thus, a selfish man could be very
attached to his wife, dote on her, and in some ways do
a lot for her. But this would not mean that he really
cared for her for her own sake. His behavior would be
compatible with his caring for her, so to speak, for her
willingness to serve him, to be at his command, to
flatter his ego. His giving could be a minor concession
for her serving him or even a further expression or
assertion of his power over her and of her dependence
on him. If he were truly selfish, then something like
this would be the most likely explanation of his
beneficent behavior.
Nevertheless, it would be wrong to say that selfish
people cannot really have friends at all, in any sense of
the term. For first of all, there are important aspects of
friendship besides caring for the otheri.e., enjoying
being with the other person, or sharing certain kinds of
activities, or liking the other person. So selfish people
can have friends, in that there are others whom they
like and enjoy sharing certain kinds of activities with.
Second, even selfish people can wish others well, be
well disposed toward others.
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45
Writing Sample
Time: 60 minutes
2 Prompts, separately timed:
30 minutes each
This is a test of your writing skills. The test consists of two parts. You will have 30 minutes to complete each
part. Use your time efficiently. Before you begin writing each of your responses, read the assignment carefully to
understand exactly what you are being asked to do. Because this is a test of your writing skills, your response to
each part should be an essay of complete sentences and paragraphs, as well organized and clearly written as you
can make it in the time allotted.
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the MCAT hold the copyrights to the content of this Practice Test. Therefore, there can be no sharing or
reproduction of materials from the Practice Test in any form (electronic, voice, or other means). If there are any
questions about the use of the material in the Practice Test, please contact the MCAT Information Line (202828-0690).
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Biological Sciences
Time: 100 minutes
Questions: 140 - 216
Most questions in the Biological Sciences test are organized into groups, each containing a descriptive
passage. After studying the passage, select the one best answer to each question in the group. Some questions are
not based on a descriptive passage and are also independent of each other. If you are not certain of an answer,
eliminate the alternatives that you know to be incorrect and then select an answer from the remaining alternatives.
Indicate your selected answer by marking the corresponding answer on your answer sheet. A periodic table is
provided for your use. You may consult it whenever you wish.
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the MCAT hold the copyrights to the content of this Practice Test. Therefore, there can be no sharing or
reproduction of materials from the Practice Test in any form (electronic, voice, or other means). If there are any
questions about the use of the material in the Practice Test, please contact the MCAT Information Line (202828-0690).
He
4.0
10
1.0
3
Li
Be
Ne
6.9
9.0
10.8
12.0
14.0
16.0
19.0
20.2
11
12
13
14
15
16
17
18
Na
Mg
Al
Si
Cl
Ar
23.0
24.3
27.0
28.1
31.0
32.1
35.5
39.9
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
Ca
Sc
Ti
Cr
Mn
Fe
Co
Ni
Cu
Zn
Ga
Ge
As
Se
Br
Kr
39.1
37
40.1
38
45.0
39
47.9
40
50.9
41
52.0
42
54.9
43
55.8
44
58.9
45
58.7
46
63.5
47
65.4
48
69.7
49
72.6
50
74.9
51
79.0
52
79.9
53
83.8
54
Rb
Sr
Zr
Nb
Mo
Tc
Ru
Rh
Pd
Ag
Cd
In
Sn
Sb
Te
Xe
85.5
55
87.6
56
88.9
57
91.2
72
92.9
73
95.9
74
(98)
75
101.1
76
102.9
77
106.4
78
107.9
79
112.4
80
114.8
81
118.7
82
121.8
83
127.6
84
126.9
85
131.3
86
Cs
Ba
La*
Hf
Ta
Re
Os
Ir
Pt
Au
Hg
Tl
Pb
Bi
Po
At
Rn
132.9
87
137.3
88
138.9
89
178.5
104
180.9
105
183.9
106
186.2
107
190.2
108
192.2
109
195.1
197.0
200.6
204.4
207.2
209.0
(209)
(210)
(222)
Fr
Ra
Ac
Unq
Unp
Unh
Uns
Uno
Une
(223)
(226)
(227)
(261)
(262)
58
(263)
59
(262)
60
(265)
61
(267)
62
63
64
65
66
67
68
69
70
71
Ce
Pr
Nd
Pm
Sm
Eu
Gd
Tb
Dy
Ho
Er
Tm
Yb
Lu
140.1
90
140.9
91
144.2
92
(145)
93
150.4
94
152.0
95
157.3
96
158.9
97
162.5
98
164.9
99
167.3
100
168.9
101
173.0
102
175.0
103
Th
Pa
Np
Pu
Am
Cm
Bk
Cf
Es
Fm
Md
No
Lr
232.0
(231)
238.0
(237)
(244)
(243)
(247)
(247)
(251)
(252)
(257)
(258)
(259)
(260)
Passage I
Autoimmune diseases result when lymphocytes from
the immune system attack the bodys own tissues. This
is normally prevented by the bodys ability of selftolerance; that is, the immune system recognizes the
bodys own tissues and forms very few lymphocytes
that act against them. Autoimmune diseases may affect
any type of body tissue.
Two hypotheses have been advanced to explain how
autoimmunity develops.
Hypothesis 1
Most of the bodys self-tolerance is generated within a
few months of birth, when the body is processing T
and Blymphocytes. Identical groups (clones) of
circulating lymphocytes remain inactive until they
encounter their specific antigens, after which they
proliferate. During this time, the process of clonal
deletion destroys any newly formed groups of
lymphocytes that might attack the bodys own tissues.
If clonal deletion of such lymphocytes does not occur
or is hindered, these lymphocytes will incorrectly
recognize a specific body tissue as foreign or non-self,
and begin to destroy it.
Hypothesis 2
In addition to effector lymphocytes (such as helper T
cells and cytotoxic T cells) that selectively attack and
destroy antigens, the body contains other lymphocytes
(suppressor T cells) that prevent this destruction by
selectively limiting the action of the effector cells.
Normally, a regulatory balance is maintained between
effector and suppressor T cells. However, when this
balance is disturbed (for example, by loss or
inactivation of suppressor-cell clones), an autoimmune
disease may result.
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Passage II
The defensive secretions of some termites contain
biologically active alcohols. Chemists have attempted
to synthesize and characterize these alcohols, and two
partial syntheses are shown in Scheme A.
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B)
C)
D)
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Passage III
When the neurotransmitter acetylcholine (ACh) is
released from vesicles in the presynaptic terminals of
neurons, it diffuses across synapses and stimulates
specific postsynaptic receptors of adjacent neurons.
Normally, most of the ACh is degraded in the synapses
by the enzyme acetylcholinesterase, which is
synthesized by the same neurons that produce ACh.
ACh is abundant in brain regions that mediate learning
and memory, and, when present at relatively high
levels, is also involved in pain relief.
A researcher used two drugs to study the role of ACh
in the learning and memory processes of rats. Drug X
is an acetylcholinesterase inhibitor, and Drug Y is a
noncompetitive blocker of postsynaptic ACh receptors.
Groups of rats were maintained on different treatment
regimens, consisting of either a placebo (an inert
substance) or a specific concentration of either Drug X
or Drug Y. Using mild foot shocks as a deterrent, the
researcher trained rats to avoid the darker compartment
of a two-chamber training box. At the beginning of
each learning session, rats were placed in the dark
chamber and given 60 seconds before mild foot shocks
were initiated. Additional shocks were administered
every 60 seconds while any rats remained in the dark
chamber.
Learning was scored by the number of trials required
before rats learned to avoid shock 100% of the time,
and memory was scored by the number of incorrect
reentries into the dark chamber (errors). Some results
are shown in figures 1 and 2.
55
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Passage IV
The ciliate protozoan Tetrahymena contains two nuclei:
a diploid, germ-line micronucleus and a 45-ploid
macronucleus that is the site of gene expression during
the vegetative state. Sexual reproduction in
Tetrahymena occurs by the process of conjugation
(Figure 1, Steps 18).
Figure 1
Adapted from Elizabeth H. Blackburn and Kathleen M. Karrer,
Genomic Reorganization in Ciliate Protozoans. 1986 by
Annual Reviews Inc.
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-D-glucuronide
The compound shown above is the -derivative
of the D-glucuronic acid. The -D-glucuronide
differs in configuration from the -derivative at:
A) C-1.
B) C-2.
C) C-3.
D) C-4.
166. Suppose that the amino acid sequences of a
protein such as cytochrome oxidase are compared
for a large number of species. The greatest
number of amino acid differences will most
likely be found between members of different:
A) phyla.
B) orders.
C) species.
D) families.
167. Which of the following recombinant processes
depends on the F factor plasmid?
A) Transformation
B) Transduction
C) Conjugation
D) Translocation
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Passage V
The actual yield of an organic reaction in water is often
lower than the theoretical yield because of a competing
hydrolysis reaction that is pH dependent. Equation 1
shows the reaction of acetic anhydride with an
aliphatic amine, and equations 2 and 3 show two
possible competing reactions that can occur in water.
Equation 1
Equation 2
Equation 3
Chemists have shown that the maximum yield for
coupling of an electrophile-nucleophile pair such as the
reactants in Equation 1 occurs at a maximum pH
(pHmax) given by Equation 4, in which Hi is a
characteristic of the electrophile and Ka is the acidity
constant of the conjugate acid of the nucleophile.
pHmax = 1/2(pHi + pKa)
Equation 4
Table 1 shows pKa values for the conjugate acids of
aniline, benzylamine, valine, and lysine.
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Passage VI
In the human lung, both alveolar ventilation and
pulmonary blood flow are required for the continuous
exchange of oxygen and carbon dioxide between
alveolar air and alveolar capillary blood. Ventilation of
the alveoli (VA) results from alternating contraction and
relaxation of thoracic respiratory muscles that cause
changes in thoracic and lung volumes, alveolar
pressure (PA), and intrapleural pressure (IPP, the
pressure of the fluid surrounding each lung). The
intrapleural cavities surrounding the two lungs are
separate. IPP is negative relative to atmospheric
pressure (P, pressure outside the body) because lung
elastic recoil tends to reduce lung volume and the
thorax tends to expand. The mean pulmonary arterial
pressure is only 20 mmHg, compared with a mean
aortic pressure of 100 mmHg. The lower pressure
pulmonary circulation supplies systemic venous blood
to alveolar capillaries (Q, the blood flow rate to the
lung). In the upright human lung, gravity causes an
uneven distribution of VA and Q (Figure 1) because it
has different effects on IPP and on alveolar capillary
perfusion pressure. In an upright (seated or standing)
human, IPP is more negative at the apex of the lung
than at the base.
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62
Passage VII
Of all invertebrate taxa, arthropods are by far the most
evolutionarily successful in terms of species longevity,
diversity, and variety of ecological niches occupied
(and often dominated). The success of arthropods
appears to be attributable to a number of factors,
including the evolution of a protective chitinous
exoskeleton, segmented bodies, jointed appendages,
and striated muscle. In these four characteristics,
arthropods differ from all other invertebrate taxa.
Though arthropods and vertebrates are similar in that
both groups have well-developed organ systems, there
are fundamental differences in these systems. For
example, all arthropods have a ventral nerve cord and
an open circulatory system. Additionally, insects have
a respiratory system in which tissues are nourished
directly with gaseous oxygen, and excretion is
accomplished by hundreds of threadlike malpighian
tubules that collect waste fluids, depositing them in the
posterior intestine.
A) I only
B) II only
C) I and III only
D) I, II, and III
183. After observing the well-defined nervous system
of several insect species, a student concludes that
all arthropods must have a true coelom. Is such a
conclusion warranted?
A) No; insects are not representative of all arthropods.
B) No; coelom development and nerve tissue
development are independent processes.
C) Yes; only a true coelom gives rise to nerve tissue.
D) Yes; both the coelom and nerve tissue are
derivatives of mesoderm.
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63
Passage VIII
Aspirin (acetylsalicylic acid) is prepared from salicylic
acid according to Reaction 1.
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64
B)
C)
D)
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Passage IX
Secondary messengers such as cAMP (cyclic
adenosine monophosphate)are substances produced by
a cell in response to stimulation of the cell's plasma
membrane by a hormone (primary messengers). When
adrenalin is present in the bloodstream, glycogen
stored in the liver is broken down into glucose
monomers. This, in turn, leads to an increase in bloodsugar levels.
Hepatocytes (liver cells) may be separated into a cell
membrane fraction and a cytosol fraction by
centrifugation. Previous experiments have shown that
the cytosol fraction contains the enzymes involved in
the breakdown of glycogen, while the membrane
fraction contains the adrenalin receptors.
Experiment 1
Adrenalin and glycogen were mixed with the various
hepatocyte fractions, with results as indicated below:
a. Cytosol + Adrenalin + Glycogen No
glucose
b. Membranes + Adrenalin + Glycogen No
glucose
c. Membranes + Cytosol + Adrenalin + Glycogen
Glucose
d. Boiled membranes + Cytosol + Adrenalin +
Glycogen No glucose
Experiment 2
Hepatocyte membrane fractions were mixed with
adrenalin and ATP (adenosine triphosphate) and
allowed to react for 3 min. The mixture was then
boiled and extracted, and a portion of the boiled extract
was purified for assay. Two of the constituents found
were cAMP and 5-AMP. Cytosol fractions and
glycogen were mixed with each of the two major
extract products as follows:
a. cAMP + Cytosol + Glycogen Glucose
b. 5-AMP + Cytosol + Glycogen No glucose
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A) Adrenalin
B) Glucose
C) ATP
D) cAMP
198. Which of the following hypotheses is NOT tested
by Experiment 1?
A) Adrenalin is a necessary component for the
breakdown of glycogen.
B) Hepatocyte cytosol contributes to the breakdown of
glycogen.
C) Boiling hepatocyte membranes affects glucose
production.
D) Hepatocyte membrane and cytosol must be present
simultaneously for glycogen to be broken down.
199. Which of the following reactant combinations
should yield glucose?
I.
II.
III.
A) I only
B) II only
C) III only
D) I and III only
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68
Passage X
A microbial agent was suspected as the cause of an
infectious human disease, though no such agent could
be found when a light microscope was used to
investigate samples of blood serum and white blood
cells from ill patients. Viewing identical samples with
the electron microscope, however, did reveal
spherically shaped objects (later identified as virions)
interspersed among certain white blood cells. The
objects, shown schematically in cross section in Figure
1, were estimated to be 100 nanometers in diameter.
Researchers further analyses of the objects showed
them to consist of RNA and core protein wrapped in a
phospholipid bilayer membrane from which
proteinaceous knobs protruded. Cell organelles could
not be identified, and all attempts to grow the objects
in the laboratory using steam-sterilized, noncellular
growth media were unsuccessful.
Figure 1
Adapted from R. C. Gallo and L. Montagnier, AIDS in 1988.
1988 by Scientific American, Inc.
II.
III.
A) II only
B) III only
C) I and II only
D) I and III only
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69
Passage XI
In the early 1900s, Diels and Alder discovered that a
conjugated diene reacts with an alkene (dienophile) at
elevated temperatures to produce the corresponding
six-membered ring.
Chemist 1
Chemist 1 proposed a concerted mechanism in which
all of the bonds are formed simultaneously, as
illustrated in Figure 1.
Figure 1
Chemist 2
Chemist 2 discovered that when the reactions in Table
1 were carried out in the presence of a Lewis acid such
as AlCl3, the reaction rate increased significantly.
Chemist 2 knew that AlCl3 complexes with the
carbonyl carbon of simple ketones to give a complex,
as shown in Figure 2.
Figure 2
Because the rates of these Diels-Alder reactions were
enhanced by the addition of a Lewis acid, Chemist 2
proposed that all Diels-Alder reactions proceed
through a similar complex to give a diionic
intermediate, in which one bond is formed more
rapidly than the other, as shown in Figure 3.
Figure 3
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70
A)
B)
B)
C)
C)
D)
D)
B)
C)
D)
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71
Compound X is classified as a:
A) dipeptide that contains one peptide bond.
B) dipeptide that contains two peptide bonds.
C) tripeptide that contains two peptide bonds.
D) tripeptide that contains three peptide bonds.
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72
(D)
(D)
(D)
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Verbal Reasoning
78 (A) (B) (C) (D)
79 (A) (B) (C) (D)
80 (A) (B) (C) (D)
81 (A) (B) (C) (D)
82 (A) (B) (C) (D)
83 (A) (B) (C) (D)
84 (A) (B) (C) (D)
85 (A) (B) (C) (D)
86 (A) (B) (C) (D)
87 (A) (B) (C) (D)
88 (A) (B) (C) (D)
89 (A) (B) (C) (D)
90 (A) (B) (C) (D)
91 (A) (B) (C) (D)
92 (A) (B) (C) (D)
93 (A) (B) (C) (D)
94 (A) (B) (C) (D)
95 (A) (B) (C) (D)
96 (A) (B) (C) (D)
97 (A) (B) (C) (D)
98 (A) (B) (C) (D)
99 (A) (B) (C) (D)
100 (A) (B) (C) (D)
101 (A) (B) (C) (D)
102 (A) (B) (C) (D)
103 (A) (B) (C) (D)
104 (A) (B) (C) (D)
105 (A) (B) (C) (D)
106 (A) (B) (C) (D)
107 (A) (B) (C) (D)
108 (A) (B) (C) (D)
109 (A) (B) (C) (D)
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Writing Sample
138
139
Biological Sciences
140 (A) (B) (C) (D)
141 (A) (B) (C) (D)
142 (A) (B) (C) (D)
143 (A) (B) (C) (D)
144 (A) (B) (C) (D)
145 (A) (B) (C) (D)
146 (A) (B) (C) (D)
147 (A) (B) (C) (D)
148 (A) (B) (C) (D)
149 (A) (B) (C) (D)
150 (A) (B) (C) (D)
151 (A) (B) (C) (D)
152 (A) (B) (C) (D)
153 (A) (B) (C) (D)
154 (A) (B) (C) (D)
155 (A) (B) (C) (D)
156 (A) (B) (C) (D)
157 (A) (B) (C) (D)
158 (A) (B) (C) (D)
159 (A) (B) (C) (D)
160 (A) (B) (C) (D)
161 (A) (B) (C) (D)
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