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erythropoeisis
Nutritional deficiencies
Anemia due to renal insufficiency
Anemia of chronic disease
Generalized bone-marrow disorders
Aplastic anemia
Primary hematopoeitic neoplasms
Infiltrative disorders due to marrow
replacement
Aplastic anemia
Classification
Acquired
Idiopathic
Chemical agents
Idiosyncratic
Physical agents
Viral infections
Miscellaneous
Inherited
Fanconis anemia
Telomerase deficiency
Clinical manifestations
Fatigue
Heart palpitations
Pallor
Infections
Petechiae
Mucosal bleeding
NO SPLENOMEGALY
Aplastic anemia
Lab findings
Severe pancytopenia with relative lymphocytosis
(lymphocytes live a long time)
Normochromic, normocytic RBCs (may be slightly
macrocytic)
Mild to moderate anisocytosis and poikilocytosis
Decreased reticulocyte count
Hypocellular bone marrow with > 70% yellow marrow
Treatment in untreated cases the prognosis is poor
Remove causative agent, if known
Anti-thymocyte globulin
Multiple transfusions
Bone marrow transplant
Related disorders
Leuco-erythroblastic reaction
Bone-marrow granuloma
Related disorders
Acquired
Congenital
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