Global Technical Strategy Malaria PDF

global technical
strategy for
malaria 20162030
Global Technical Strategy for Malaria 20162030
ISBN 978 92 4 156499 1
Global Malaria Programme

World Health Organization
20 avenue Appia
1211 Geneva 27
Switzerland
gts-cover-2.indd 1
12/6/2015 13:32
GLOBAL TECHNICAL
STRATEGY FOR
MALARIA 20162030
........................................................................................................
WHO Library Cataloguing-in-Publication Data

Global technical strategy for malaria 2016-2030.
1.Malaria - prevention and control. 2.Mosquito Control. 3.Endemic Diseases. 4.Health Planning. I.World Health
Organization.
ISBN 978 92 4 156499 1
(NLM classification: WC 765)
World Health Organization 2015

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All photos from shutterstock | Front cover from left to right: Maodoltee, Hector Conesa, Nate Derrick,
Pablo Rogat.
The definitive version of the strategy can be found in the official records of the Sixty-eighth World Health
Assembly (document WHA68/2015/REC/1).
Printed in the United Kingdom
2
global technical strategy for malaria 20162030
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TABLE OF CONTENTS
ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
FOREWORD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
NEED FOR A POST-2015 TECHNICAL STRATEGY . . . . . . . . . . . . . . . . . . 4
STRATEGY DEVELOPMENT PROCESS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
VISION, GOALS AND PRINCIPLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
PATH TO MALARIA ELIMINATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
STRATEGIC FRAMEWORK. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
THREE PILLARS OF THE STRATEGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Pillar 1. Ensure universal access to malaria prevention,
diagnosis and treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Pillar 2. Accelerate efforts towards elimination and
attainment of malaria-free status . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Pillar 3. Transform malaria surveillance into a core intervention . . . . . 19
SUPPORTING ELEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
Supporting element 1. Harnessing innovation and expanding
research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
Supporting element 2. Strengthening the enabling environment . . . . . 24
COST OF IMPLEMENTING THE GLOBAL TECHNICAL
STRATEGY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
MEASURING GLOBAL PROGRESS AND IMPACT . . . . . . . . . . . . . . . . . . 26
ROLE OF THE SECRETARIAT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
GLOBAL TECHNICAL STRATEGY AT A GLANCE . . . . . . . . . . . . . . . . . 29
GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030
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ACKNOWLEDGEMENTS
The Global Technical Strategy for Malaria 2016-2030 was developed through
an extensive consultation process the began in June 2013 and culminated in
the documents adoption by the World Health Assembly at its 68th meeting in
May 2015. The strategy was developed in close collaboration with numerous
colleagues and partners worldwide and under the overall leadership of Robert
Newman, John Reeder and Pedro Alonso, Directors of the Global Malaria
Programme.
The preparation of the strategy was coordinated by a Steering Committee
chaired by Pedro Alonso and including Kevin Baird, David Brandling-Bennett,
Tom Burkot, Lesong Conteh, Azra Ghani, Margaret Gyapong, Corine Karema,
Sandii Lwin, Fatoumata Nafo-Traore, Bernard Nahlen, Abdisalan Noor, Gao Qi,
Ciro de Quadros, Ana Carolina Santelli and Wichai Satimai, with Secretariat
support from Erin Shutes, Kristine Silvestri, Sunetra Ghosh and George Davis.
The Global Malaria Programme gratefully acknowledges the important contributions to developing the Strategy by members of WHOs Malaria Policy
Advisory Committee chaired by Kevin Marsh and including Salim Abdulla, Fred
Binka, Patricia Graves, Brian Greenwood, Rose Leke, Elfatih Malik, Sylvia Meek,
Kamini Mendis, Allan Schapira, Laurence Slutsker, Marcel Tanner, Neena Valecha
and Nicholas White.
For their critical inputs to drafting and editing, thanks are due to the staff of
the Global Malaria Programme, including Andrea Bosman, Richard Cibulskis,
Stefan Hoyer, Tessa Knox, Michael Lynch, Abraham Mnzava, Peter Olumese,
Edith Patouillard, Aafje Rietveld, Pascal Ringwald, Zsofia Szilagyi and Emmanuel
Temu. Many thanks to Graham Brown and Rachel Bronzan for their key contributions to drafting, and to David W. FitzSimons for providing a final technical
edit of the document.
The Malaria Regional Advisors and their teams in WHOs Regional and
Country Offices provided extensive input and support for the seven regional
consultations that facilitated the engagement of over 400 technical experts
representing more than 70 Member States. The Global Malaria Programme is
grateful for all of their contributions and especially to Hoda Atta, Keith Carter,
Eva Christophel, Elkhan Gasimov, Leonard Ortega and Issa Sanou. Zsofia
Szilagyi coordinated the official documentation process for the World Health
Assembly. Camille Pillon coordinated the online consultation and worked on
design and layout.
The Technical Strategy was developed in close alignment with the Roll Back
Malaria Partnerships Action and Investment to defeat Malaria 2016-2030 (AIM)
to ensure shared goals and complementarity. Many thanks to the AIM Taskforce
and Vanessa Racloz for the strong coordination and collaboration.
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FOREWORD
The World Health Organizations Global Technical Strategy for Malaria 20162030 has been developed with the aim of helping countries reduce the human
suffering caused by the worlds deadliest mosquito-borne disease.
Adopted by the World Health Assembly in May 2015, the strategy provides
comprehensive technical guidance to countries and development partners for
the next 15 years, emphasizing the importance of scaling up malaria responses
and moving towards elimination. It also highlights the urgent need to increase
investments across all interventions including preventive measures, diagnostic
testing, treatment and disease surveillance as well as in harnessing innovation
and expanding research.
By adopting this strategy, WHO Member States have endorsed the bold vision
of a world free of malaria, and set the ambitious new target of reducing the
global malaria burden by 90% by 2030. They also agreed to strengthen health
systems, address emerging multi-drug and insecticide resistance, and intensify
national, cross-border and regional efforts to scale up malaria responses to
protect everyone at risk.
By taking forward this strategy, countries will make a major contribution to
implementing the post-2015 sustainable development framework. A major
scale-up of malaria responses will not only help countries reach the healthrelated targets for 2030, but will contribute to poverty reduction and other
development goals.
DR MARGARET CHAN
DIRECTOR-GENERAL
WORLD HEALTH ORGANIZATION
In the next 18 months, we will develop and roll out implementation plans in all
WHO regions and support countries in updating their national malaria plans.
We stand ready to expand our reach and increase our support to all countries
irrespective of where they are along the elimination continuum.
Recent progress on malaria has shown us that, with adequate investments and
the right mix of strategies, we can indeed make remarkable strides against
this complicated enemy. We will need strong political commitment to see this
through, and expanded financing.
We should act with resolve, and remain focused on our shared goal: to create
a world in which no one dies of malaria. I remain confident that if we act with
urgency and determination, we can beat this disease once and for all.
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BACKGROUND
Malaria is caused by parasites of the Plasmodium family and transmitted by female
Anopheles mosquitoes. There are four different human malaria species (P.falciparum,
P.vivax, P.malariae and P.ovale), of which P.falciparum and P.vivax are the most preva
lent and P.falciparum the most dangerous. P.knowlesi is a zoonotic plasmodium that
is also known to infect humans.
Despite being preventable and treatable, malaria continues to have a devastating
impact on peoples health and livelihoods around the world. According to the latest
available data, about 3.2 billion people were at risk of the disease in 97 countries,
territories and areas in 2013, and an estimated 198 million cases occurred (range:
124 million283 million). In the same year, the disease killed about 584 000 people
(range: 367 000755 000), mostly children aged under 5 years in sub-Saharan Africa.1
In most countries where malaria is endemic, the disease disproportionately affects
poor and disadvantaged people, who have limited access to health facilities and can
barely afford the recommended treatment.
Between 2001 and 2013, a substantial expansion of malaria interventions contributed to a 47% decline in malaria mortality rates globally, averting an estimated 4.3
million deaths. In the WHO African Region, the malaria mortality rate in children
under 5years of age was reduced by 58%. During the same period, the global incidence of malaria was reduced by 30%.1 Target 6.C of Millennium Development
Goal6, namely Have halted by 2015 and begun to reverse the incidence of malaria
and other major diseases, has already been reached, and 55 of the 106 countries
that had malaria transmission in 2000 are on track to achieve the goal of reducing
malaria incidence by 75% by 2015, as set by the Health Assembly in 2005 in reso
lution WHA58.2 on malaria control.2
Despite this progress, the disease remains endemic in all six WHO regions and the
burden is heaviest in the African Region, where an estimated 90% of all malaria deaths
occur. Two countries the Democratic Republic of the Congo and Nigeria account
for about 40% of estimated mortality due to malaria worldwide. Around the world,
millions of people remain without access to malaria prevention and treatment, and
most cases and deaths go unregistered and unreported. Given the projected growth
in the size of the worlds population by 2030, more people will be living in countries
where malaria is a risk, putting further strains on health systems and national malaria
programme budgets.
NEED FOR A POST-2015 TECHNICAL

STRATEGY
In the early part of the 21st century, malaria received worldwide recognition as a
priority global health issue. T
his renewed attention ended an era of neglect between
the 1960s and the late 1990s, and reversed dramatic rises in malaria morbidity and
mortality rates. In order to ensure that malaria trends remain on a downward trajectory, unremitting political commitment, substantial and predictable financing, and
increased regional collaboration are necessary. A powerful and coordinated global
1 World malaria report 2014. Geneva: World Health Organization; 2014 (http://www.who.int/malaria/
publications/world_malaria_report_2014/en/, accessed 10 March 2015).
2 Resolution WHA58.2 on malaria control. Fifty-eighth World Health Assembly, Geneva: World Health
Organization; 2005 (see document WHA58/2005/REC/1, http://apps.who.int/gb/ebwha/pdf_files/WHA58REC1/english/A58_2005_REC1-en.pdf, accessed 10 March 2015).
........................................................................................................
response together with continued investment in research and development will rid
entire continents of the disease and eventually eradicate malaria from the world.
Although the implementation of core interventions expanded greatly between 2000
and 2014, the gains achieved are fragile and unevenly distributed. T
he human toll of
malaria, and the global risk it still poses, remains unacceptably high. In many affected
countries, social unrest, conflict and humanitarian disasters are major obstacles to
progress. The recent outbreak of Ebola virus disease in West Africa, which affected
countries that are highly endemic for malaria, has had a devastating impact on basic
health service delivery, including the ability to control malaria. Recent outbreaks of
malaria in countries that had been malaria-free, and resurgences in countries that
have made important progress in reducing malaria morbidity and mortality rates in
the past decade, highlight the continual threat of re-establishment and resurgence
and the need for vigilance to ensure that these areas of transmission are promptly
identified and rapidly contained.
Given the association between malaria transmission and climate, long-term malaria
efforts will be highly sensitive to changes in the worlds climate. It is expected that
without mitigation climate change will result in an increase in the malaria burden in
several regions of the world that are endemic for the disease, particularly in densely-populated tropical highlands. Increasing economic development, urbanization and
deforestation are also expected to contribute to changes in transmission dynamics,
while projected population growth in areas where malaria poses a high risk will
increase the need to optimize coverage of interventions.
Malaria interventions are highly cost-effective and demonstrate one of the highest
returns on investment in public health. In countries where the disease is endemic,
efforts to reduce and eliminate malaria are increasingly viewed as high-impact strat
egic investments that generate significant returns for public health, help to alleviate
poverty, improve equity and contribute to overall development.
The world has reached a critical juncture in the fight against malaria. There is both
an opportunity and an urgent need to accelerate progress by reducing morbidity
and mortality in all countries, by increasing the number of malaria-free countries,
territories and areas, and by identifying approaches that aim to reduce transmission. Progress can be hastened through a major expansion of existing interventions,
by making the response to malaria a higher technical, financial and political priority, and by ensuring that the development and use of new tools and solutions are
maximized.
Efforts to prevent and control malaria contribute to and benefit from sustainable
development. T
he objectives of reducing the disease burden and eliminating malaria
are closely linked to several of the sustainable development goals being considered
for the post-2015 period. Well-established linkages and factors include the contribution of malaria to the poverty cycle, the concentration of disease in vulnerable popu
lations and those with poor access to health services, and its detrimental impact on
education through missed school days and the cognitive effects of chronic anaemia.
The Malaria Policy Advisory Committee, established in 2011 to provide independent strategic advice to WHO on developing policy recommendations on malaria,
recommended to the Director-General the development of a post-2015 global technical strategy on malaria. Member States at the Sixty-sixth World Health Assembly in
2013 expressed support for its preparation.3 T
he strategy, adopted by the Sixty-eighth
World Health Assembly in May 2015 in resolution WHA68.2, succeeds the previous
WHO global malaria strategy, which was endorsed by the Ministerial Conference on
Malaria (Amsterdam, The Netherlands, 1992) in the World Declaration on Malaria.
3 Summary records of the Sixty-sixth World Health Assembly, eleventh meeting of Committee A, section 1.
Geneva: World Health Organization; 2013 (document WHA66/2013/REC/3) (http://apps.who.int/gb/ebwha/
pdf_files/WHA66-REC3/EN/A66_REC3-en-A11.pdf, accessed 10 March 2015).
........................................................................................................
Adoption of the strategy by the Health Assembly provides the basis for ensuring that
WHO is well equipped to support the completion of the unfinished health-related
Millennium Development Goals agenda, which is one of the Organizations six leadership priorities for the period 20142019.4
Opportunities. Since 2000, eight countries have eliminated malaria and many
others have reduced transmission to low levels. T

he knowledge gained from these
efforts will be informative in designing programmes in the future. The next 15 years
are likely to be strongly shaped by: technological advances; innovations in medicines,
vaccines and vector control; and improved strategies for delivering commodities.
Some of the new tools are expected to have significant additional impact, and, once
validated, will need to be swiftly incorporated into national malaria responses.
Challenges. The fight against malaria is being prolonged, and in some places
slowed down, by several interconnected challenges. T

he greatest of these is the lack
of robust, predictable and sustained international and domestic financing. T
his is compounded by the difficulty in maintaining political commitment and ensuring regional
collaboration at the highest levels. T
he second important challenge is biological: the
emergence of parasite resistance to antimalarial medicines and of mosquito resist
ance to insecticides. This double threat has the potential to weaken seriously the
effectiveness of malaria responses and to erode the gains recently achieved.
Other challenges that need to be met in order to accelerate progress are systemic and technical. They include: the inadequate performance of health systems,
for instance weak management of supply chains and the unregulated private health
sector in many countries, which allows the use of ineffective antimalarial medicines
or vector control products; weak systems for surveillance, monitoring and evaluation,
which compromise the ability to track gaps in programme coverage and changes
in disease burden; the lack of adequate technical and human resource capacities to
sustain and scale up efforts; the disproportionate risk of malaria among hard-to-reach
populations, including high-risk occupational groups, migrants, people in humanitarian
crises, and rural communities with poor access to health services; and the lack of
adequate tools to diagnose and treat effectively infections due to P.vivax and other
non-falciparum malaria parasites.
Another important challenge is that many people who are infected with malaria
parasites remain asymptomatic or undiagnosed and are therefore invisible to the
health system. Further, in some settings the density of parasitaemia is so low in a
substantial proportion of individuals that it cannot be detected with current routine
diagnostic tools.These people unwittingly contribute to the cycle of malaria transmission. If future disease control and elimination strategies are to succeed, they will need
to take into account this large infectious parasite reservoir. T
he expected develop
ment and availability over the next decade of new tools and approaches should
help the detection and targeting of this reservoir and the clearing of plasmodia from
asymptomatic carriers.
The emergence of drug and insecticide resistance is compounded by additional biological challenges, which need to be tackled by national malaria programmes. In some
parts of the world, existing vector control tools cannot effectively protect against
the disease given the diversity of malaria vectors and differences in their behaviours.
In countries where both P.falciparum and P.vivax are present, the burden of disease
due to P.vivax is more difficult to reduce because the parasite forms in the liver a
dormant hypnozoite stage which is currently undetectable and leads to relapses,
thereby contributing to disease transmission. In addition, human infection with zoonotic plasmodia such as P.knowlesi presents new challenges to malaria control and
elimination.
4 WHO, Twelfth General Programme of Work 20142019, approved by the Sixty-sixth World Health
Assembly in resolution WHA66.1. Geneva: World Health Organization; 2013 (http://apps.who.int/iris/
bitstream/10665/112792/1/GPW_2014-2019_eng.pdf, accessed 10 March 2015).
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This technical strategy provides a framework for the development of tailored programmes to accelerate progress towards malaria elimination. T
his framework should
be the foundation of strategies for national and subnational malaria programmes.
It defines a clear and ambitious path for countries in which malaria is endemic and
their global partners in malaria control and elimination for the next 15 years. It
emphasizes the need for universal coverage of core malaria interventions for all
populations at risk, and highlights the importance of using high-quality surveillance
data for decision-making in order to drive tailored responses consistent with national
or subnational goals. T
he strategy identifies areas where innovative solutions will be
essential for attaining its goals. It summarizes the estimated costs of implementing
the strategy and provides an estimate of the research and development costs for
innovative new tools.
STRATEGY DEVELOPMENT PROCESS

Following the support expressed by Member States at the Sixty-sixth World Health
Assembly for the development of a global malaria strategy for the post-2015 period,
the Secretariat held seven regional consultations.5 Input was gathered from more than
400 experts representing national malaria programmes, health ministries, research
organizations and implementing partners. The process, led by the Secretariat, was
supported by both the Malaria Policy Advisory Committee and a dedicated Steering
Committee for the Global Technical Strategy, consisting of leading malaria experts,
scientists and representatives of countries in which malaria is endemic, who provided
additional extensive inputs to the initial draft document. Following these consult
ations, a revised draft was prepared by the Secretariat for an online consultation
which was open for comment between 11 July and 15 August 2014.
VISION, GOALS AND PRINCIPLES

The vision of WHO and the global malaria community is a world free of malaria. As
part of this vision, the strategy sets ambitious yet feasible global targets for 2030 with
milestones for measuring progress for 2020 and 2025. Countries will set their own
national or subnational targets, which may differ from the global targets. The goals,
milestones and targets are set out in Table 1.
These goals apply to all types of human malaria and have been developed after
reviewing (1)the targets of national malaria programmes as stated in their national
strategic plans, (2) the magnitude of decreases in the numbers of cases and deaths
due to malaria between 2000 and 2012, as reported to WHO, and (3) the results
of mathematical modelling of transmission of falciparum malaria in order to estimate
the potential impact of applying different combinations of recommended interventions between 2016 and 2030.
Modelling suggests that, if coverage of malaria interventions remains at current levels,
incidence could increase moderately as a result of a partial loss of malaria immunity
among populations that have experienced marked reductions in transmission intensity. However, this rise and its consequences could be averted through a concerted
effort to optimize the use of currently available tools, particularly vector control, at
levels above 80% coverage of at-risk populations, which could significantly reduce
5 WHO Global Malaria Programme, Global Technical Strategy meeting reports. Geneva: World Health
Organization; 2014 (http://www.who.int/malaria/areas/global_technical_strategy/meetings/en/, accessed
10 March 2015).
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TABLE 1. GOALS, MILESTONES AND TARGETS FOR THE GLOBAL TECHNICAL

STRATEGY FOR MALARIA 20162030
VISION A WORLD FREE OF MALARIA
GOALS
MILESTONES
TARGETS
2020
2025
2030
1. Reduce malaria mortality

rates globally compared
with 2015
At least 40%
At least 75%
At least 90%
2. Reduce malaria case

incidence globally
compared with 2015
At least 40%
At least 75%
At least 90%
3. Eliminate malaria from

countries in which malaria
was transmitted in 2015
At least
10 countries
At least
20 countries
At least
35 countries
4. Prevent re-establishment
of malaria in all countries
that are malaria-free
Re-establishment Re-establishment Re-establishment

prevented
prevented
prevented
incidence of and deaths due to malaria. Given that reaching this level of coverage
will be operationally difficult, further innovations in tools and approaches are needed
for elimination of transmission in areas where transmission rates are high; they are
also needed in areas and for population groups that are presently hard to reach with
current interventions.
Five principles underlie the technical strategy for malaria. All countries can accelerate
efforts towards elimination through combinations of interventions tailored to local
contexts. Country ownership and leadership, with involvement and participation of
communities, are essential to accelerating progress through a multisectoral approach.
Improved surveillance, monitoring and evaluation, as well as stratification by malaria
burden, are required to optimize the implementation of malaria interventions. Equity
in access to health services, especially for the most vulnerable and hard-to-reach
populations, is essential. Finally, innovation in tools and implementation approaches
will enable countries to maximize their progression along the path to elimination.
PATH TO MALARIA ELIMINATION

Progression towards malaria-free status is a continuous process, and not a set of
independent stages. Countries, subnational areas and communities are situated at
different points on the path towards malaria elimination, and their rate of progress
will differ and depend on the level of investment, biological determinants (related
to the affected populations, the parasites and the vectors), environmental factors,
the strength of health systems as well as social, demographic, political, and economic
realities.
At all levels of endemicity, the risk of malaria varies significantly within a country
or area, and the same strategy is not necessarily appropriate for all settings within
a country. As intervention coverage is increased and malaria incidence is reduced,
the heterogeneity in incidence and transmission rates is likely to further increase. A
key approach to optimizing malaria responses within a country will be structuring
programmes in response to stratification by malaria burden and based on an analysis
........................................................................................................
of past malaria incidence data, risk determinants related to the human host, parasites,
vectors and the environment that together with an analysis of access to services.
The performance of national health systems and their adaptability to new opportunities are two of the key determinants of the rate of progress along the path.
As malaria programmes reduce transmission to low or very low rates, they should
shift the focus from preventing, detecting and treating clinical cases to preventing,
detecting and treating every malaria infection. This change requires strengthened and
sustained epidemiological and entomological surveillance systems, a requirement that
can be satisfied only through substantial long-term financial and political commitment
as well as significant structural and organizational changes in malaria programmes.
The first priority for all countries where transmission rates of malaria are high or
moderate is to ensure maximal reduction of morbidity and mortality through sustained provision of universal access to quality-assured and appropriate vector control
measures, diagnostics and antimalarial medicines, together with the implementation
of all WHO-recommended preventive therapies that are appropriate for that epi
demiological setting. These activities must be backed up by efficient disease surveillance systems, robust entomological and drug efficacy surveillance, as well as strong
public health communication and behavioural change programmes.
In countries where the potential for malaria transmission is high, optimal application
of all appropriate interventions will result in marked falls in morbidity and mortality
rates, but these may not be sufficient to eliminate malaria. In these settings, additional tools will be needed to accelerate progress. Many new tools are already in
development and could be available within the next five to 10years (see section on
Harnessing innovation and expanding research).
Once programmes have reduced transmission to very low levels, they should assess
the technical, operational and financial feasibility of elimination and the programmatic
capacity, including the ability of surveillance systems to track and manage every case of
malaria infection, needed in order to eliminate every malaria infection. In addition to
domestic considerations, available resources and preparedness, the situation in neighbouring countries and the risk of imported infections should be taken into account.
As programmes approach elimination or work to prevent re-establishment of transmission, all cases of malaria infection need to be detected and managed by general
health services, both public and private, and reported as a notifiable disease to a
national malaria registry. Patients diagnosed with malaria must be treated promptly
with effective antimalarials in order to avoid preventable deaths and to decrease
the probability of onward transmission in the community. In addition, entomological
surveillance systems should be maintained so that appropriate vector control interventions can be introduced or modified as necessary.
STRATEGIC FRAMEWORK
In order to accelerate progress towards elimination, WHO urges affected countries
and the global malaria community to maximize the impact of existing life-saving tools
and strategies. Until new and improved tools and approaches become available, there
is an urgent need to adopt and expand implementation of all WHO-recommended
strategies so as to increase the effectiveness of responses and end preventable malaria
deaths. The strategy is built on three pillars with two supporting elements that guide
global efforts to move closer to malaria elimination. These are summarized below.
Pillar 1. Ensure universal access to malaria prevention, diag
nosis and treatment. The WHO-recommended package of core interventions namely quality-assured vector control, chemoprevention, diagnostic
testing and treatment can dramatically reduce morbidity and mortality. In
........................................................................................................
areas of moderate-to-high transmission, ensuring universal access of populations at risk to interventions should be a principal objective of national
malaria programmes.The metrics of success are the reductions in malaria case
incidence and malaria mortality rates. WHO recommends implementing two
sets of interventions in a complementary way: (1)prevention strategies based
on vector control, and, in certain settings and in some population groups,
administration of chemoprevention, and (2)universal diagnosis and prompt
effective treatment of malaria in public and private health facilities and at
community level. Structuring programmes in response to stratification of
malaria by disease burden and including an analysis of past malaria incidence
data, risk determinants related to the human host, parasites, vectors and the
environment that together with an analysis of access to services will enable
the tailoring of interventions to the local context and ensure efficient use of
resources.
Pillar 2. Accelerate efforts towards elimination and attainment
of malaria-free status. Countries need to intensify efforts to reduce
onward transmission of new infections in defined geographical areas, particularly in settings where transmission is low. In addition to core interventions, attaining this objective will entail targeting both parasites and vectors in
well-defined transmission foci, guided by active case detection and case investigations as part of a malaria surveillance and response programme. In some
settings, the achievement of elimination may require the use of medicines
for prophylaxis, or other possible new approaches to remove the infectious
reservoir once those are recommended by WHO. The development and
adoption of innovative solutions will be essential to respond to the spread of
insecticide resistance and residual transmission, and to target the hypnozoite
reservoirs of P.vivax.
Pillar 3. Transform malaria surveillance into a core interven
tion. Strengthening malaria surveillance is fundamental to programme planning and implementation and is a crucial factor for accelerating progress. All
countries where malaria is endemic and those susceptible to the re-establishment of malaria should have an effective health management and information
system in place for helping national malaria programmes to direct resources
to the most affected populations, identify gaps in programme coverage, detect
outbreaks, and assess the impact of interventions in order to guide changes
in programme orientation. At very low levels of transmission, surveillance
should trigger a locally-tailored response to every detected infection, the
detection of gaps in programme coverage, declines in the effectiveness of
tools, or the occurrence of outbreaks.
Supporting element 1. Harnessing innovation and expanding re
search. In support of these three pillars, countries where malaria is endemic
and the global malaria community should harness innovation and increasingly
engage in basic, clinical and implementation research. Successful innovation in
product development and service delivery will make a major contribution to
accelerating progress. Basic research is essential for a better understanding of
the parasites and the vectors, and to develop more effective diagnostics and
medicines, improved and innovative vector control methods, and other tools
such as vaccines. Implementation research will be fundamental to optimizing impact and costeffectiveness, and facilitating rapid uptake in populations
at risk.
Supporting element 2. Strengthening the enabling environment.
Strong political commitment, robust financing and increased multisectoral collaboration are key factors for further progress. To optimize national malaria
10
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responses, an overall strengthening of health systems and improvement in the
enabling environment are also crucial. Strong health systems, both public and
private, are important for reducing both the disease burden and the potential
for onward transmission of parasites, and enable the adoption and introduction of new tools and strategies within the shortest possible time frame. In
turn, the expansion of malaria interventions can be used as an entry point for
strengthening health systems, including maternal and child health programmes
and laboratory services, and to build stronger systems for health information
and for disease and entomological surveillance. Finally, the empowerment of
communities, capacity building and supportive supervision for a strong health
workforce and regulatory frameworks are important in ensuring achievement
of the vision, goals and milestones in this strategy.
THREE PILLARS OF THE STRATEGY

PILLAR 1. ENSURE UNIVERSAL ACCESS TO MALARIA
PREVENTION, DIAGNOSIS AND TREATMENT
The WHO-recommended package of core interventions to prevent infection
and reduce morbidity and mortality comprises vector control, chemoprevention,
diagnostic testing and treatment. These elements are detailed in the following
paragraphs.
Vector control
Maximize the impact of vector control. Vector control is an essential com-
ponent of malaria control and elimination. T

he capacity of vectors to transmit parasites and their vulnerability to vector control measures vary by mosquito species and
are influenced by local environmental factors. V
ector control must be implemented
on the basis of local epidemiological and entomological data. At present, the two
core, broadly-applicable vector control interventions are long-lasting insecticidal nets
and indoor residual spraying.6
National malaria programmes need to ensure that all people living in areas where the
risk of malaria is high are protected through the provision, use and timely replacement of long-lasting insecticidal nets or, where appropriate, the application of indoor
residual spraying. A second core intervention should not be introduced as a means
of compensating for deficiencies in the implementation of the first.7 However, spraying may be added in certain situations in order to either prevent or mitigate resistance in areas where nets are routinely used the decision being informed by local
data. When those two interventions are deployed together, an insecticide with a
different mode of action to that used on nets should be used for spraying. Supple
mentary methods may be appropriate in specific settings, for instance larval source
6 WHO recommendations for achieving universal coverage with long-lasting insecticidal nets in malaria
control, September 2013 (revised March 2014). Geneva: World Health Organization; 2013 (http://
www.who.int/malaria/publications/atoz/who_recommendations_universal_coverage_llins.pdf,
accessed 10 March 2015); WHO. An operational manual for indoor residual spraying (IRS) for malaria
transmission, control and elimination. Geneva: World Health Organization; 2013 (http://apps.who.int/iris/
bitstream/10665/80126/1/9789241505123_eng.pdf, accessed 10 March 2015).
7 WHO guidance for countries on combining indoor residual spraying and long-lasting insecticidal nets. Geneva:
World Health Organization; 2014 (http://www.who.int/malaria/publications/atoz/who-guidance-combiningirs_llins-mar2014.pdf, accessed 10 March 2015).
11
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management where mosquitoes aquatic habitats are few, fixed and findable.8 Effective
planning, application and monitoring of larval source management require specialized
capacity that is currently lacking in most malaria programmes. This capacity needs to
be built.
Numerous situations exist where transmission of malaria parasites continues even
when universal coverage with insecticidal nets or spraying has been achieved.9 For
optimal impact of these interventions, programmes should ensure that vectors
are exposed and susceptible to the insecticides used. Long-lasting insecticidal nets
counter late-night and indoor-biting mosquitoes, and indoor residual spraying targets
indoor-resting mosquitoes. T
his means that mosquitoes that bite in the early evening,
or which are outdoor biting or resting, can evade the most frequently used interventions, leading to residual malaria transmission. T
ransmission can continue when
people are away from houses or otherwise not under nets at the times when and
places where malaria vectors prefer to bite. T
o maximize the impact of current vector control tools where they are appropriate, countries should implement such tools
effectively and should not compromise on quality through poor implementation or
use of substandard products.
Maintain adequate entomological surveillance and monitoring. To
enable an effective vector control response, entomological surveillance and monitoring of coverage and impact of vector control interventions must be included in
national surveillance systems. Vector control should be guided by local epidemiological and entomological data including insecticide resistance and vector behaviour.
Countries should collect data across all settings, including those areas that are malariafree but at risk of re-establishment of malaria.
Entomological surveillance must include periodic assessment of vector species present, their abundance and seasonality, time and place of biting, resting and host preference (vector behaviour), insecticide susceptibility status and underlying resistance
mechanisms in order to predict vulnerability to interventions. Also essential is routine monitoring of coverage and impact of interventions, the physical condition of
long-lasting insecticidal nets, the actual use of nets and their perceived usefulness by
end users, and the residual effect of insecticides. T
he data generated should be used
to inform decisions on the timing of spraying activities, contribute to net-replacement
strategies, and guide the development and deployment of tools including behavioural
change communication activities.
Manage insecticide resistance and residual transmission. Even though
core vector control interventions continue to be effective in most areas, growing

physiological resistance of mosquitoes to insecticides and the combination of vector
and human behaviour that sustains continued transmission are major challenges that
require an urgent and coordinated response. If left unchecked, insecticide resistance
could lead to substantial increases in malaria incidence and mortality, with devastating
public health consequences. All countries where malaria is endemic, including those
where resistance has yet to be detected, are urged to develop and implement plans for
monitoring and managing insecticide resistance.10 Strategic use of current tools pre-
8 WHO interim position statement: the role of larviciding for malaria control in sub-Saharan Africa. Geneva:
World Health Organization; 2012 (http://www.who.int/malaria/publications/atoz/interim_position_
statement_larviciding_sub_saharan_africa.pdf, accessed 10 March 2015); WHO. Larval source management
a supplementary measure for malaria vector control: an operational manual. Geneva: World Health
Organization; 2013 (http://apps.who.int/iris/bitstream/10665/85379/1/9789241505604_eng.pdf, accessed 10
March 2015).
9 WHO. Control of residual malaria parasite transmission: guidance note. Geneva: World Health Organization;
2014 (http://www.who.int/malaria/publications/atoz/technical-note-control-of-residual-malaria-parasitetransmission-sep14.pdf, accessed 10 March 2015).
10 WHO. Global plan for insecticide resistance management in malaria vectors. Geneva: World Health
Organization; 2012 (http://apps.who.int/iris/bitstream/10665/44846/1/9789241564472_eng.pdf,
accessed 10March 2015); WHO. Test procedures for insecticide resistance monitoring in
malaria vector mosquitoes. Geneva: World Health Organization; 2013 (http://apps.who.int/iris/
12
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serves their efficacy. Methods of managing resistance include use of insecticides with
different modes of action through either periodic changes (rotations) between rounds
of indoor residual spraying or multiple combined interventions. Vector behaviour
that compromises the effectiveness of core interventions must be tackled through
the use of new tools. The cost of vector control products is a major barrier to
the implementation of strategies to prevent and mitigate insecticide resistance and
reduce residual transmission. Countries should better forecast vector control product requirements and support pooled procurement. Such steps should enhance
manufacturers confidence, help to stabilize the market, lead to price reductions and
encourage innovation.
Strengthen capacity for evidence-driven vector control. For effective
delivery and monitoring of vector control interventions, national malaria programmes

need to invest in human resources and organizational and infrastructural development that will boost capacity to generate and analyse essential data.11 A long-term
strategic plan should be developed for building sustainable human resource capacity
and establishing career structures and systems to ensure optimal delivery of vector
control interventions.Such capacity underpins all activities for malaria control and
elimination, and prevention of the re-establishment of the disease.
Implement malaria vector control in the context of integrated vector

management. To maximize the impact of malaria vector control including main-
taining adequate entomological surveillance and monitoring, managing insecticide

resistance and strengthening capacity for evidence-based vector control national
malaria programmes should apply the principles of integrated vector management.
Integrated vector management is a rational decision-making process for the optimal
use of resources for vector control. It seeks to improve the efficiency, costeffectiveness, ecological soundness and sustainability of disease-vector control with the ultim
ate goal of preventing the transmission of vector-borne diseases. Countries should
develop and implement national plans on integrated vector management as part of
their broader strategy to control malaria. Because implementation of vector control
involves different sectors, countries should also strengthen intersectoral coordination
for maximum impact.
Chemoprevention
Expand preventive treatment to prevent disease in the most vulner
able groups. Preventive treatment strategies are key elements of the multipronged
strategy to reduce disease burden and transmission, and they need to be substantially
expanded to help countries to reduce their malaria burden. T
his intervention suppresses existing infections and prevents the consequences of parasitaemia, including
disease and death. T
he strategies for preventive treatment vary, depending on the
intensity of transmission and the level of parasite resistance to antimalarial medicines
in a given region.
WHO-recommended preventive treatment against malaria presently includes intermittent preventive treatment of pregnant women, intermittent preventive treatment
of infants, and seasonal chemoprevention for children aged under 5 years.12 These
bitstream/10665/80139/1/9789241505154_eng.pdf, accessed 10March 2015).
11 WHO guidance note on capacity building in malaria entomology and vector control. Geneva: World Health
Organization; 2013 (http://www.who.int/malaria/publications/atoz/who_guidance_capacity_building_
entomology.pdf, accessed 10 March 2015).
12 WHO. Updated WHO policy recommendation: intermittent preventive treatment of malaria in pregnancy
using sulfadoxine-pyrimethamine (IPTp-SP), Geneva: World Health Organization; 2012 (http://www.who.int/
malaria/iptp_sp_updated_policy_recommendation_en_102012.pdf, accessed 10 March 2015); WHO policy
recommendation on intermittent preventive treatment during infancy with sulphadoxine-pyrimethamine
(SP-IPTi) for Plasmodium falciparum malaria control in Africa. Geneva: World Health Organization; 2010
(http://www.who.int/malaria/news/WHO_policy_recommendation_IPTi_032010.pdf, accessed 10 March
2015); WHO policy recommendation: seasonal malaria chemoprevention (SMC) for Plasmodium falciparum
13
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interventions are recommended in areas of moderate-to-high malaria transmission
in sub-Saharan Africa, with seasonal malaria chemoprevention being recommended
only in areas of highly seasonal transmission across the Sahel subregion. Preventive
treatment strategies currently target falciparum malaria and need to be developed
for other types of human malaria.
Protect all non-immune travellers and migrants. Chemoprophylaxis is the

administration of subtherapeutic doses of antimalarial medicines at regular intervals
sufficient to prevent malaria disease. Chemoprophylaxis should be given to individuals exposed to high malaria risk in combination with advice about measures to
reduce vector bites, particularly non-immune travellers, who are more susceptible to
malaria illness and death. It is also recommended for travellers within countries from
malaria-free areas to areas with high malaria risk.
Diagnostic testing and treatment

Ensure universal diagnostic testing of all suspected malaria cases. All
patients who are suspected to have malaria should have the diagnosis confirmed by
parasite detection methods such as quality-assured microscopy or a rapid diagnostic
test. Both public and private sector health services should confirm diagnosis before
administering antimalarial treatment. Every confirmed case should be tracked and
reported in the surveillance system in order to inform programme planning. Ensuring
universal diagnostic testing will reduce the over-use of artemisinin-based combination
therapies the first-line treatment for uncomplicated malaria and reduce the drug
pressure on parasites.13
Expansion of diagnostic testing will provide timely and accurate surveillance data
based on confirmed rather than suspected cases. Additionally, it will lead to improved
identification and management of the many non-malarial febrile illnesses presumed
to be malaria solely on the basis of the presence of fever. Expanding access to prompt
diagnostic testing has lagged behind vector control prevention efforts, but strengthening diagnosis and treatment in all settings will help to reduce malaria morbidity and
mortality. WHO recognizes that testing and radical treatment of vivax malaria safely
and effectively currently requires two diagnoses: the presence of P.vivax parasites and
glucose-6-phosphate dehydrogenase status.
Provide quality-assured treatment to all patients. Ensuring universal
access to WHO-recommended antimalarial medicines is crucial in all settings in

order to prevent the progression of uncomplicated malaria to severe illness and
death. After diagnostic confirmation, every patient with uncomplicated P. falciparum
malaria should be treated with quality-assured artemisinin-based combination therapy. In areas where chloroquine-susceptible P.vivax is present, uncomplicated nonfalciparum malaria should be treated with either chloroquine or an artemisinin-based
combination therapy known to be effective in the area . In addition to the artemisinin
-based combination therapy or chloroquine, all non-pregnant adults and children with
P.vivax or P.ovale who are not glucose-6-phosphate dehydrogenase deficient should
receive a 14-day course of primaquine to prevent future relapse. Every severe case
of malaria caused by P.falciparum, P.vivax or P.knowlesi should be treated parenterally
with artesunate or artemether, followed by a full oral course of an artemisinin-based
dombination therapy. Severe malaria requires urgent medical attention and WHOs
detailed recommendations have been made available to countries.14
malaria control in highly seasonal transmission areas of the Sahel sub-region in Africa. Geneva: World
Health Organization; 2013 (http://www.who.int/malaria/publications/atoz/smc_policy_recommendation_
en_032012.pdf, accessed 10 March 2015).
13 WHO. Universal access to malaria diagnostic testing: an operational manual, November 2011
(rev. February 2013. Geneva: World Health Organization; 2011 (http://whqlibdoc.who.int/
publications/2011/9789241502092_eng.pdf, accessed 10 March 2015).
14 WHO. Guidelines for the treatment of malaria, Third edition. Geneva: World Health Organization; 2015 (http://
www.who.int/malaria/publications/atoz/9789241549127/en/, accessed 10 June 2015); WHO. Management
14
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Malaria programmes should develop detailed national treatment guidelines that
take into account local antimalarial drug resistance patterns and health service cap
acities. Countries should select WHO-recommended artemisinin-based combination
therapies with more than 95% efficacy demonstrated through therapeutic efficacy
monitoring in local sites. Fixed-dose formulations (combining two different active
ingredients co-formulated in one tablet) are strongly recommended as they facilitate
adherence to treatment and reduce the potential misuse of individual components of
co-blistered medicines. Oral artemisinin-based monotherapy should never be used
for the treatment of uncomplicated malaria as this may promote the development
of resistance to artemisinin.
Scale up community-based diagnostic testing and treatment. Training
and deployment of community health workers and volunteers can substantially complement and extend the reach of public health services, particularly in rural and
remote areas, where health infrastructures tend to be the weakest and malaria transmission the highest. The strategic use of community health workers and volunteers
in malaria prevention and care not only bridges health system gaps, but ensures a
continuum of care for the most disadvantaged populations. National malaria programmes should expand integrated community case management of malaria, pneumonia and diarrhoea, with a focus on children under 5 years of age.
Monitor safety and efficacy of antimalarial medicines and manage

antimalarial drug resistance. Enhanced pharmacovigilance and surveillance of
the efficacy of antimalarial medicines are essential in order to detect unexpected

adverse events and reduced efficacy so that the most appropriate combinations
can be selected for national treatment policies. Countries should monitor every
two years the efficacy of first-line malaria therapies against both falciparum and
vivax malaria using the standard WHO protocol for therapeutic efficacy studies.15
A treatment failure rate exceeding 10% should prompt a change in the national antimalarial treatment policy. For the time being, artemisinin-based combination ther
apies remain highly effective, provided that the partner medicines remain efficacious.
Caution is required, however, as the emergence of artemisinin resistance increases
the risk of resistance to the partner medicines in the combination.
Contain antimalarial drug resistance. Protecting the efficacy of artemisinin-
based combination therapies and developing new combinations should be a top prior
ity for both countries where malaria is endemic and the global malaria community.16
In countries and areas where artemisinin and artemisinin-based combination ther
apies continue to be fully effective, there is a need to promote correct medicine use
with special attention to expanding diagnostic testing and quality-assured treatment
and to extend all basic malaria interventions, including vector control, in order to
reduce the potential emergence of resistance. Countries where artemisinin resist
ance is reported are urged to intensify malaria control in order to reduce the burden
of the disease and delay or prevent spread of resistance. In areas of low transmission
but where resistance to artemisinin is present, countries should target rapid elimin
ation of falciparum malaria.
Eliminate falciparum malaria from the Greater Mekong subregion.
P.falciparum resistance to artemisinin has emerged independently in multiple geographical locations in the Greater Mekong subregion in South-East Asia. The situ
ation is worst along the CambodiaThailand border, where P.falciparum has become
of severe malaria: a practical handbook. Third edition. Geneva: World Health Organization; 2013 (http://apps.
who.int/iris/bitstream/10665/79317/1/9789241548526_eng.pdf, accessed 10 March 2015).
15 WHO. Methods for surveillance of antimalarial drug efficacy. Geneva: World Health Organization; 2009
(http://whqlibdoc.who.int/publications/2009/9789241597531_eng.pdf, accessed 10 March 2015).
16 WHO, Roll Back Malaria Partnership. Global plan for artemisinin resistance containment. Geneva: World
Health Organization; 2011 (http://www.who.int/malaria/publications/atoz/artemisinin_resistance_
containment_2011.pdf, accessed 10 March 2015).
15
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resistant to almost all available antimalarial medicines. The emergence of multidrug
resistance could seriously threaten progress achieved in this region to date, and could
lead to a rise in the disease burden in other parts of the world.17 Elimination of
P.falciparum malaria is the only strategy that can prevent the spread of resistance; this
should be an urgent priority in the Greater Mekong subregion, while current tools
are effective.
Remove all inappropriate antimalarial medicines from markets. All
countries in which malaria is endemic should ensure that all inappropriate antimalarial
medicines are removed from private sector markets. National regulatory authorities
are urged to regulate against production, marketing authorization, export, import
and use of oral artemisinin-based monotherapies. Countries should also take de
cisive steps, including surveillance and regulatory action as well as stringent follow-up,
to remove ineffective antimalarial medicines from health facilities and pharmacies,
including their provision through informal providers. T
hese efforts will be crucial for
preserving the efficacy of artemisinin-based combination therapies, and will make a
substantial contribution to accelerating progress on the path to elimination.
All countries should aim to eliminate malaria. Attaining this objective will
entail targeting both the vectors and parasites. Preventing contact between people
and vectors will reduce onward transmission of new infections, while clearing
the parasites from the large number of people with undiagnosed infections will
speed declines in transmission. Over the next decade, new tools and approaches
will become available which will help to target the infectious parasite reservoir in
humans. The main technical recommendations summarized under this pillar are
based on existing tools and approaches but the recommendations are expected to
be expanded with 23 years.
PILLAR 2. ACCELERATE EFFORTS TOWARDS ELIMINATION

AND ATTAINMENT OF MALARIA-FREE STATUS
Refocus programmes. Once the number of malaria cases has been reduced to
low levels in a given country or subnational area, the malaria programmes priorities
and activities may need to be readjusted to complete the final phase of elimination.
Thus, in addition to the interventions mentioned under Pillar 1, programmes should
enhance surveillance to ensure that every infection is detected, implement targeted
measures for attacking both parasites and vectors in order to interrupt local transmission, eliminate all parasites from humans, and manage the risk of re-establishment
through imported malaria.
Enact legislation. New legislation is needed in order to support changes in pro-
gramme prioritization, namely to ensure that the over-the-counter sale of antimalarial

medicines is banned and that surveillance is further strengthened to include compulsory notification of all confirmed cases of infection detected in both public and
private health care facilities. In addition, health ministries with the support of relevant authorities need to assume direct oversight of supply management for malaria
medicines; build a centralized reporting system for epidemiological surveillance of
malaria, for vector control data, outbreak reporting, and preparedness and response;
and intensify coordination between public, private and community-based agencies
and services.
Renew political commitment and deepen regional collaboration. The
final phase of elimination needs strong political commitment, predictable long-term

financing, and increased collaboration between neighbouring countries. In many coun17 WHO. Emergency response to artemisinin resistance in the Greater Mekong subregion: regional
framework for action 20132015. Geneva: World Health Organization; 2013 (http://apps.who.int/iris/
bitstream/10665/79940/1/9789241505321_eng.pdf, accessed 10 March 2013).
16
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tries, there is an urgent need to expand efforts to support at-risk communities in
low-transmission areas, especially in remote and hard-to-reach areas. Solutions should
be found for protecting itinerant population groups and migrant workers within and
across countries by informing them of the potential dangers of the disease, and providing access to prevention tools and treatment through accessible health clinics.
Reduce the number of undetected infections. Ensuring that malaria para-
sites are fully cleared from infected people through public health interventions will
require new approaches that are not yet part of the WHO-recommended arsenal
of tools. Strategies such as mass administration of medicines have been successfully
used in the past, and are currently being explored in a range of transmission settings.
Research is evaluating the potential role of administering transmission-blocking medi
cines in high-transmission settings in order to accelerate progress towards elimination.
Other research is evaluating the impact and longer-term effect of administration of
effective antimalarials to either an entire population or targeted population groups,
including treatment of infected individuals screened for malaria parasites with highly
sensitive tests.
Implement targeted malaria vector control. As transmission decreases to
low levels in countries or subnational areas, universal coverage of populations at risk

of malaria with vector control interventions should be maintained in most settings to
prevent resurgences. For a given area, the defined population at risk will likely differ as
programmes proceed along the path to elimination. A shift from universal coverage
to targeting of vector control to specific populations or areas may be justified in circumstances where the inherent transmission potential is low, surveillance systems are
strong, there is a high level of preparedness and the ability exists to respond quickly
in the event of a resurgence. T
argeted indoor residual spraying plays an important
role in some settings as a response to outbreaks and resurgences, or to eliminate
transmission foci. As transmission declines there may be an increased need for supplementary measures such as larval source management.
Prevent re-establishment of local malaria transmission. Even after the
disease has been eliminated from a country or subnational area, continued importation of malaria cases means that the quality of case detection must remain high.
Vigilance for possible renewed local transmission is a responsibility of the general
health services as part of their normal function in communicable disease control, in
collaboration with other relevant sectors (such as agriculture, environment, industry
and tourism). Individuals who plan travel to areas where malaria is endemic should
be provided with health information, chemoprophylaxis and advice about measures
to protect against mosquito bites, aimed at reducing the importation of parasites.
Visitors and migrants from endemic areas should be informed of the risks of malaria
and given easy access to free-of-charge diagnostic and treatment facilities. Vector
control must continue to be used to contain local outbreaks and protect areas that
are known to be receptive to the resumption of transmission as well as exposed
to frequent importation of malaria parasites. T
he patterns of vigilance that need to
be applied in order to ensure the successful maintenance of the malaria-free status
depend on the vulnerability and receptivity of an area. T
he programme for prevention of re-establishment of transmission has an unlimited duration. T
hus, surveillance
should be maintained in countries that no longer have transmission.
Implement transmission-blocking chemotherapy. Transmission-blocking
chemotherapy is the use of effective antimalarial medicines to reduce the transmission of gametocytes, the sexual stage of plasmodia that are infectious to mosquito
vectors, thereby interrupting the malaria transmission cycle. WHO recommends
transmission-blocking chemotherapy to reduce malaria transmission, particularly in
areas threatened by resistance of P.falciparum to artemisinin and as part of strategies
17
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to eliminate P.falciparum.18 This intervention is currently recommended in areas with
low transmission and where treatment coverage is high. T
ransmission-blocking strategies are currently available for falciparum malaria but have not been developed for
other malaria parasites.
Detect all infections to attain elimination and prevent re-establish

ment. In settings where the rate of transmission is very low, active detection and
investigation of infections in addition to free malaria care and notification at health
facilities are important for clearing residual foci of transmission.19 Case investigations
and detection of infections among people who share the living environment with
someone diagnosed with malaria at a health facility will provide information on
potential exposure to the same sources of infection in order to elucidate whether
local transmission is occurring or if cases have been imported.
Use of medicines to reduce the parasite pool. Use of antimalarials is an
element of the elimination strategy as they can eliminate the parasite pool in the
treated population and, when used preventively, reduce both the pool of susceptible
individuals and transmissibility of gametocytes. In the future, WHO will assess the
potential role of medicines in killing mosquitoes before they are able to transmit
malaria parasites, and their potential role in treating all infections regardless of clinical
symptoms or health-seeking behaviour. In work aimed at elimination, all patients with
laboratory-confirmed vivax or ovale malaria should be treated with a regimen for
a radical cure to clear all remaining hypnozoites, which could later cause a relapse.
Devise P.vivax-specific strategies. For elimination to succeed, greater atten-
tion must be given to P.vivax, a parasite less well understood than P.falciparum. Vivax
malaria presents multiple challenges and needs specific strategies. The challenges
include the following:
P. vivax tolerates a wider range of environmental conditions than P. falciparum
and therefore has a wider geographical range;
P. vivax can be transmitted from humans to mosquitoes before infected people develop symptoms;
conventional vector control methods (long-lasting insecticide-treated nets
and indoor residual spraying) may be less effective against P. vivax because,
in many areas where P. vivax predominates, vectors bite early in the evening,
obtain blood meals outdoors and rest outdoors;
dormant hypnozoites are more difficult to detect because the parasitaemia is
typically low and because the dormant hypnozoites residing in the liver cannot
be detected with existing diagnostic tests;
hypnozoites can give rise to multiple relapses and contribute to significant
morbidity and onward transmission;
P. vivax hypnozoites can only be eliminated through a 14-day course of prima
quine, which can produce serious side effects (haemolytic anaemia) in patients
who have glucose-6-phosphate dehydrogenase deficiency, and such treatment is contraindicated in vulnerable population groups such as infants and
pregnant or breastfeeding women;
18 WHO. Updated WHO policy recommendation: single dose primaquine as a gametocytocide in Plasmodium
falciparum malaria. Geneva: World Health Organization; 2012 (http://www.who.int/malaria/pq_updated_
policy_recommendation_en_102012.pdf, accessed 10 March 2015).
19 WHO. Disease surveillance for malaria elimination: an operational manual. Geneva: World Health
march 2015); WHO. Policy brief on malaria diagnostics in low-transmission settings. Geneva: World Health
Organization; 2014. (http://www.who.int/malaria/publications/atoz/policy-brief-diagnosis-low-transmissionsettings/en/, accessed 10March 2015).
18
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testing for glucose-6-phosphate dehydrogenase deficiency is challenging and
not available in many settings;
chloroquine-resistant vivax malaria is spreading.
Use surveillance as an intervention in elimination programmes. As
malaria programmes progress towards elimination, the aim of surveillance is to detect

all malaria infections, whether symptomatic or not; to investigate each individual case
of infection, differentiating imported cases from those acquired locally; and to ensure
that each detected case is promptly treated in order to prevent secondary infections.
Although infections occur sporadically or in distinct foci, surveillance systems must
cover an entire country, with particular attention to areas with ongoing or a recent
history of transmission. Countries should monitor imported infections, which represent a significant proportion of all infections in the elimination phase and may pose
a risk for re-establishment of transmission in areas in which it had previously been
interrupted.20
PILLAR 3. TRANSFORM MALARIA SURVEILLANCE INTO

A CORE INTERVENTION
Irrespective of where countries are on the path to elimination, surveillance of malaria
should be upgraded to a core intervention in national and subnational malaria strategies. Surveillance as an intervention encompasses tracking of disease and programmatic responses and taking action in response to data received. At present, most
high-burden countries are not in a position to capture essential malaria data on
a continuing basis, thereby making it difficult to optimize responses, assess disease
trends and respond to outbreaks. Surveillance may function most intensively as an
intervention when programmes are closest to elimination, but effective surveillance is
required at all points on the path to elimination. The benefits of effective surveillance
and the actions needed to transform surveillance are described below.
Strong malaria surveillance enables programmes to optimize their operations, by
empowering programmes:
to advocate investment from domestic and international sources, commensurate with the malaria disease burden in a country or subnational area;
to allocate resources to populations most in need and to interventions that
are most effective, in order to achieve the greatest possible public health
impact;
to assess regularly whether plans are progressing as expected or whether
adjustments in the scale or combination of interventions are required;
to account for the impact of funding received and enable the public, their
elected representatives and donors to determine if they are obtaining value
for money;
to evaluate whether programme objectives have been met and learn what
has worked and not worked so that more efficient and effective programmes
can be designed.
Surveillance in areas of high transmission. Data analysis and programme

monitoring are based on aggregate numbers, and actions are undertaken at a popu
lation level to ensure that all populations have access to services and there are no
March 2015).
19
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adverse disease trends.21 Accurate and timely information on numbers of and trends
in malaria-associated deaths is a key requirement for tracking the progress of malaria
control. Concerted efforts should be made to ensure that all admissions for malaria
to hospitals and health centres and deaths from malaria therein are confirmed by
a parasitological test and reported through a national surveillance system. T
he representativeness of hospital data should be characterized in selected sites with welldefined catchment populations and that continuously track the cause of death.
Surveillance in areas of low transmission. In areas where rates of trans-
mission are low or moderate, there is appreciable heterogeneity in the distribution

of malaria and it becomes increasingly important to identify the population groups
most susceptible to disease, and to target interventions appropriately. Malaria can be
concentrated in marginalized populations, such as those living in remote or border
areas, itinerant and migrant workers, and tribal populations with limited access to
services. It may be necessary to take diagnostic testing and treatment services directly
to populations without access to services (i.e. to undertake proactive case detection
and treatment). As the immunity of populations at risk wanes as interventions take
effect, it is important for programmes to be vigilant against potential outbreaks, with
intensified reporting (e.g. weekly) of the incidence of infections and the monitoring
of major determinants of transmission, such as meteorological data.
Surveillance in areas targeted for elimination of malaria. Malaria-specific
reporting systems are increasingly needed to satisfy the additional information

demands for targeting and monitoring interventions in particular risk groups and foci.
As progress is made towards elimination, it becomes necessary to investigate individual cases of infection or clusters of cases in order to understand risk factors and
eliminate foci of transmission. It also becomes increasingly important to ensure that
surveillance systems capture data on cases detected by private sector care providers,
both formal and informal. Increasing resources and capacity are required to run and
maintain malaria surveillance systems that become more complex and resourceintensive in moving to the elimination phase, and additional skills, training and activities
will have to be provided for the personnel involved. Strong surveillance systems need
to be maintained to sustain the status of elimination once it is achieved; countries also
need to monitor the risk of importation (vulnerability) and the transmission potential
in risk areas (receptivity).22
Invest in routine information systems. Routine information systems are
crucial for surveillance at all stages of malaria control and form the basis for monitoring of malaria programme activities. Sufficient investments must be made in the
management and use of data from improved routine information systems in order
to generate the information needed for programme planning, implementation and
evaluation. Adequate financial and logistical support is needed for provision of office
supplies and equipment, training and retraining of staff, supervision of health facilities,
and communications. Data reporting requires management with quality controls in
place and good follow up. Building the technical capacity of staff for data analysis and
interpretation is the overriding need in order to enable programmes to use surveillance information most effectively.
Collect necessary data for understanding disease trends and overall

programme performance. Necessary information includes data on resources
available for malaria control (programme financing, staff and commodities), existing
levels of service provision (access to services and intervention coverage), and trends in
health services utilization. It also covers data on populations affected, including malaria
21 WHO. Disease surveillance for malaria control: an operational manual. Geneva: World Health Organization;
2012 (http://apps.who.int/iris/bitstream/10665/44851/1/9789241503341_eng.pdf, accessed 10 March 2015).
March 2015).
20
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parasite prevalence rates and factors that are associated with a higher risk of acquiring malaria. Multiple sources of data include routine information systems (to track
finances, commodity flows, service delivery, and disease trends), health facility surveys (to track implementation of services delivered by health facilities), household
surveys to track programme coverage and parasite prevalence (in populations), and
findings of implementation research. Entomological monitoring systems are required
to update information periodically on vectors and their behaviour and susceptibility
to insecticides. T
herapeutic efficacy studies are essential for detecting resistance to
antimalarial medicines. T
he weight given to different data sources will vary according to the level of malaria transmission and the maturity and capacities of a malaria
programme.
Develop national strategic plans that take into account the epidemio
logy and heterogeneity of malaria in a country. As intervention coverage
is increased and malaria incidence is reduced, the heterogeneity in incidence and

transmission rates increases. A key approach to optimizing malaria responses within
a country or territory will be stratification, in which a country or area is divided into
smaller units where different combinations of interventions may need to be delivered.
National strategic plans should take into account the readiness of health systems to
expand malaria programmes and identify the resources required to achieve intended
levels of coverage and impact. T
hey should define the role of different stakeholders in
the implementation of the plan and set targets for monitoring progress and ensuring
accountability.
Monitor the implementation of national malaria strategic plans at

regular intervals. In particular, annual reviews should be undertaken before
budgets are prepared; mid-term reviews may be conducted to assess interim pro
gress; and a final programme review should be undertaken before development of
the next strategic plan. Feedback showing the status of selected key indicators should
be communicated to districts and health facilities on a monthly or quarterly basis
and include private health facilities. It is important that data are summarized in ways
that staff in health facilities and districts can readily assess the facilities performance.
Programme monitoring and surveillance should not be confined to malaria programme managers and implementers. Other government departments, elected leaders, community members and donors have a stake in ensuring high quality malaria
programmes and need to be able to scrutinize the operations they are supporting.
If involved in the review process, they can help to ensure that malaria programmes
are responsive to populations needs and that malaria control and elimination are
promoted as a development priority.
Ensure the surveillance system is monitored. Routine health information
systems and well-functioning disease surveillance enable programmes to monitor

malaria financing, intervention coverage and disease trends. It is important that performance of the surveillance system itself is also monitored through metrics such
as the percentage of health facilities submitting monthly reports, the proportion of
health facilities receiving quarterly feedback, and, in the advanced phase of malaria
elimination, the proportion of cases and deaths investigated. Other important char
acteristics that should be evaluated periodically include timeliness, accuracy, representativeness and validity. Monitoring the surveillance system itself will identify
weaknesses and enable actions to be taken to improve surveillance, which in turn
can improve the performance of the malaria programme and accelerate progress
towards malaria elimination.
21
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SUPPORTING ELEMENTS
SUPPORTING ELEMENT 1. HARNESSING INNOVATION
AND EXPANDING RESEACH
Important new tools are expected to become available within the lifetime of this
strategy. T
hese include new and more effective medicines, new combinations of
medicines, improved diagnostics, new vaccines, new insecticides and other innovative
vector control tools. Until new tools are available, programmes should undertake
implementation research to refine approaches to applying existing interventions
most effectively and efficiently in local contexts. Implementation research will need
to focus in particular on population coverage and compliance in the short and long
terms as well as human resource issues. T
hese studies should be so designed as to
provide results of sufficient quality to provide evidence for policy recommendations.
As candidate tools and approaches become available, they will be reviewed and
advised upon by WHO and national regulatory bodies. Countries should ensure the
existence of a regulatory environment that facilitates rapid assessment and appropriate uptake of validated tools is critical. Bottlenecks to the introduction of new tools
must be identified through implementation research and removed early in order to
facilitate immediate use once the evidence-base is available to define the appropriate
conditions for their deployment. T
he priorities in five different areas are outlined
below.
Vector control
Numerous potential tools and approaches are under development for overcoming
the specific challenges of vector insecticide resistance and residual transmission. T
hese
include new insecticides, formulations or methods of application, new attractants
and repellents, new bioactive agents (e.g. fungi or endo-symbionts), new mosquito
life-cycle targets (e.g. sugar feeding, mating or oviposition phases), and genetically-
modified mosquitoes. New strategies are also being explored to improve the delivery of interventions, such as the novel use of mobile-phone technology and digital
mapping. T
ools are also needed for protection of people when they are outside of
homes protected by core interventions owing to occupational or other reasons.
The improvement of existing core vector control interventions is a priority area
that requires further attention, given the expected continued large expenditures on
these tools. Beside the integration of new active ingredients into these interventions,
the development and validation of nets with improved or prolonged residual effect
and physical integrity as well as usefulness are important. Countries should therefore
continue to implement operational research to improve access, ownership and usage
of nets and quality and uptake of indoor residual spraying, including components of
behavioural change communication.
It is vital that options are urgently explored to ensure timely and affordable access to
improved vector control tools, including those to mitigate insecticide resistance and
residual transmission. Countries and the global community must work with industry
and research institutions to identify and validate markers of insecticide resistance,
assess the extent and drivers of residual transmission, and evaluate candidate tools.
Clear definition of the evidence needed to validate new tools is required along with
a recognized process for recommending programmatic implementation.
Quality assurance of existing and new vector control products and equipment is
crucial for sustained efficacy and safety. As global and national capacity to conduct
quality control assessments is currently limited, countries must invest in building sufficient expertise and necessary facilities.
22
........................................................................................................
Diagnostic testing and treatment
Research is required to develop tools that can more readily detect low-level parasit
aemia in asymptomatic carriers and ascertain the effectiveness of different screening
strategies both at higher transmission levels, in order to appropriately target interventions, and when countries enter the elimination phase. Better species-specific pointof-care rapid diagnostic tests are needed for all non-falciparum malaria parasites, and
diagnostics for hypnozoites of P. vivax are needed.
Simple, point-of-care rapid diagnostic tests are needed to establish the glucose-6phosphate dehydrogenase status of individuals in order to expand access to treatment of vivax malaria with 8-aminoquinoline antimalarials.
A robust pipeline of new candidate therapeutic agents is required because the longterm usefulness of any medicine or combination is threatened by the emergence
and spread of resistance. T
he ideal combination would be a safe, effective and affordable single-dose treatment that can produce radical cure, reduce transmissibility of
gametocytes, with prophylactic effect for both P.falciparum and P.vivax infections, and
can be used during pregnancy and in people with glucose-6-phosphate dehydrogen
ase deficiency. New regimens of medicines that are safe, well-tolerated, affordable,
avoid promoting resistance and demonstrate broad spectrum of activity need to
be developed for treatment of confirmed clinical cases and for potential mass use
against the parasite reservoir, including the sexual stages of both P.falciparum and
P.vivax. New regulatory pathways will need to be created to develop novel chemoprophylactic agents as well as clear research strategies for developing antimalarial
medicines for preventive treatment.
Reliable and easily applied and interpretable tests for molecular markers of drug
resistance for all components of medicine combinations are urgently required. T
he
identification and validation of molecular markers will improve our ability to monitor
the emergence and spread of resistance to each medicine compound individually. In
addition to molecular markers detecting resistance of P.falciparum, markers are also
needed to detect resistance of P.vivax. T
he monitoring of molecular markers for
drug resistance, once they become available, will be useful particularly in areas of low
transmission where therapeutic efficacy studies are becoming increasingly difficult to
perform.
Context-specific strategies are required to understand better the treatment-seeking
behaviours of people in regions with continuing transmission in order to increase
demand for treatment, testing and recommended therapy. Innovative methods
should be devised in order to ensure that both public and private providers, and
those outside the formal health system, adhere to standard guidelines for detecting,
treating and recording all malaria cases.
Malaria vaccines
Malaria vaccines are expected to be an important addition to the arsenal of tools in
the future. Several vaccine candidates, with different modes of action, are currently in
various stages of development to prevent P.falciparum and P.vivax infections. At least
one of these (RTS,S) is close to licensure and review for policy recommendation.
The global health community has called for the development and licensing, by 2030,
of malaria vaccines with protective efficacy of at least 75%.Malaria vaccines are currently envisaged as a complementary tool that should not replace the core package
of interventions.
Surveillance
Advances in information technology and communications offer prospects of increased
timeliness of reporting, better sharing of data (between information systems and different levels of a health system) and enhanced data analyses. Information technology
23
........................................................................................................
can be applied to optimize and improve procurement and supply management, early
warning systems, and the mapping of gaps in service delivery. Moreover, adoption of
new technologies should offer the chance to improve management of systems and
strengthening capacities and the human resources involved.
Efforts are needed to enable better sharing of results of interventions and drug-
sensitivity testing and information about advances in surveillance and research that
are often generated and held by multiple institutions. All agreements for research or
service delivery should include a provision for data-sharing, possibly through open-
access portals.
Research is needed to identify which strategies are most effective in detecting cases,
and to assess the effectiveness of response packages once cases have been detected.
Elimination
Research is required to define the range of transmission settings in which reducing transmission by targeting the parasite reservoir is an effective intervention. This
research will need also to define optimum combinations of approaches and to optimize intervals between treatments and methods for monitoring the effectiveness of
this intervention. The latter includes assessment of highly sensitive submicroscopic
diagnostic assays for detecting both P.falciparum and P.vivax parasitaemia.
Relapses of infection with P.vivax contribute to a significant proportion of transmission of vivax malaria from its hypnozoites in the liver. Strategies aimed at this parasite
reservoir need to be developed as part of vivax elimination strategies, including those
for people not eligible for primaquine therapy.
Basic research is needed to develop new tools to prevent transmission, including
vaccines that target different stages of the parasite life cycle and may be effective
in preventing all infections, or by directly targeting the sexual stages and preventing
infection of and from mosquitoes.
SUPPORTING ELEMENT 2. STRENGTHENING THE ENABLING

ENVIRONMENT
Malaria interventions need to be embedded in, and supported through, a strong
enabling environment that can ensure that efforts are expanded in an effective and
sustainable manner.The main activities to contribute to this enabling environment are
as follows.
Increase international and domestic financing. There is an urgent need to
increase and sustain high-level political commitment and the availability of predictable
and long-term financing for malaria programmes. International donors are encouraged to maintain and increase commitments to malaria goals and programmes; new
financing solutions should be conceived to tap into emerging development financing and private sector resources. Countries where malaria is endemic are urged to
increase the domestic resources directed to strengthening health systems and combating the disease. Robust and predictable financing is also essential to sustain recent
successes: if countries were to fall back on existing levels of intervention coverage,
because of lack of funding, some of the recent gains in global malaria efforts could
be lost. Maintenance of robust malaria programmes and capacities is paramount
at every step along the path to elimination and in preventing re-establishment of
transmission.
Ensure robust health sector response. In many countries in which malaria is
endemic, inadequate health system capacities are a major obstacle to further progress
and acceleration. Substantial investments are needed to strengthen health systems,
particularly basic health infrastructures, commodity-delivery systems, pharmaceutical
24
........................................................................................................
regulation, human resources, and vital registration systems in order to improve the
environment in which national malaria programmes operate. Strong collaboration
between malaria programmes and other health programmes such as reproductive
health, maternal and child programmes, laboratory services and regulatory author
ities (for diagnostic devices, medicines and insecticides) is essential for the successful
implementation of malaria interventions.
Strengthen health workforce and malaria expert base. In most countries
where malaria is endemic, there is a chronic shortage of skilled health professionals,

clinical practices are outdated, surveillance systems are inadequate, and monitoring
and evaluation programmes are weak. Malaria programmes operate in a complex
environment, with a continuous need to adjust responses in line with outbreaks and
resurgences, changing transmission patterns, and development of drug and insecticide
resistance. Robust expansion of malaria interventions requires significantly expanded
human resource capacities at national, district and community levels. T
he education,
training and motivation of health workers, programme staff and malaria researchers
including adequate mentoring, supervision, and compensation is the key to ensuring
programme effectiveness. T
here are several new tools on the horizon, whose introduction will require new skills and even further investments in capacity building. A
strengthening of the workforce should be recognized as an essential part of health
systems strengthening.
Ensure the sustainability of malaria responses. To do this and to maxi-
mize the potential of malaria investments, national malaria strategic plans should be
embedded in a broader health systems approach. A stronger focus on improved
supply chains for quality-assured diagnostics, medicines and vector control tools, wellplanned procurement, the harnessing of new technologies for data collection and
management, and better regulation and oversight of the activities of private sector
pharmaceutical vendors are all crucial to making systemic improvements. High-quality
and efficient provision of malaria prevention and care in both the public and private
health sectors will benefit from, and help to build, stronger health systems.
Improve government stewardship and cross-border collaboration of

malaria programmes. Given the large number of stakeholders and the import-
ant role in malaria programmes of development partners, private industry, research

and academia, private sector health facilities, nongovernmental organizations and
community health workers, national public health programmes in countries in which
malaria is endemic should improve their overall coordination of the work on malaria.
Effective cross-border collaboration between national programmes must be initiated and strengthened in order to ensure optimal coverage of intervention in these
areas. National programmes should ensure that all work on programme implementation and elimination is fully in line with national strategic priorities and complies
with WHO recommendations, and that appropriate regulatory frameworks exist to
ensure safe use of quality-assured tools by appropriately trained personnel.
Strengthen multisectoral collaboration. Collaboration with non-health sec-
tors needs to be augmented. National malaria programmes should become an integral part of poverty-reduction strategies, national development plans and regional
development cooperation strategies. T
he response should be elevated from a
single-disease approach to a health-in-all-policies approach. T
he engagement of ministries of finance, education, environment, industry, transport and tourism is especially
important, as is the active contribution of regulatory authorities. For vector control,
integrated vector management sometimes offers the appropriate platform for efficient delivery of interventions.
Encourage private sector participation. The private health sector, including
industry, health facilities and other actors, has a vital role in the development and
delivery of commodities and services, for instance through the development of new
tools and interventions and bringing them to market. A stronger engagement will
be essential to improve the quality of interventions, including formal and informal
25
........................................................................................................
private sector provision of patient care and the appropriate reporting to the national
surveillance systems of all malaria cases, treatment outcomes and deaths. New and
improved partnerships are needed to improve the supply chain for commodities.
These partnerships can also play an important role in protecting workers who are
recruited for major development projects and treating those who become infected.
Empower communities and engage with nongovernmental organiza

tions. Close collaboration with community leaders and nongovernmental imple-
menting partners is an essential factor for success. Malaria interventions cannot

succeed unless communities adopt governmental guidance on the use of prevention
tools and recommended therapies. Integrated, people-centred, community services
are needed, and these should be introduced in coordination with health care providers in the public and private sectors. Populations living in remote or hard-toreach areas and with limited access to health facilities can only be supported through
community-based approaches, often in partnership with nongovernmental implementing partners. Well-planned public health communication and behavioural change
programmes are essential to educating affected communities about the benefits, and
correct use, of malaria prevention tools.
COST OF IMPLEMENTING THE GLOBAL

TECHNICAL STRATEGY
To achieve the milestones and goals set out in this strategy, malaria investments,
including both international and domestic contributions, need to increase substantially above the current annual spending of US$ 2.7 billion. T
he annual investment will
need to increase to an estimated total of US$ 6.4 billion per year by 2020 to meet
the first milestone of 40% reduction in malaria incidence and mortality rates. T
his
should then be further increased to an annual investment of an estimated US$7.7
billion by 2025 to meet the second milestone of a 75% reduction. T
o achieve the
90% reduction goal, the total annual malaria spending will need to reach an estimated
US$ 8.7 billion by 2030. T
he cost of implementation has been estimated from the
quantities of goods required for expanding interventions, multiplied by the estimated
unit cost for the provider of delivering each intervention, and an analysis of surveillance and financing data available in national strategic plans and WHOs annual
world malaria reports.23 Additional funding of an average of US$ 673 million (range:
US$524 million822 million) will be needed annually for research and development.
This estimate stems from a risk-adjusted portfolio model of malaria research and
innovation needs until 2030.
MEASURING GLOBAL PROGRESS

AND IMPACT
Global progress in reducing mortality and morbidity and finally eliminating malaria
will be based on countries surveillance efforts. Progress will be measured using multiple data sources, including routine information systems, household and health facility
surveys and longitudinal studies. Progress should be monitored through a minimal
set of 14 outcome and impact indicators (see Table2) drawn from a larger set of
23 All world malaria reports can be downloaded from: http://www.who.int/malaria/publications/world_
malaria_report/en/ (accessed 10 March 2015).
26
........................................................................................................
indicators recommended by WHO and routinely tracked by malaria programmes.
Certain indicators are applicable only to subsets of countries, which are defined by
levels of malaria endemicity (e.g. intermittent preventive treatment of malaria for
pregnant women in sub-Saharan Africa) or by the position on the path to elimination
(e.g. investigation of cases and foci for programmes engaged in malaria elimination
activities). For other indicators, such as those for vector control, the population at risk
who may benefit from the intervention may be defined differently for programmes at
different points along the path to elimination. Countries should ensure that a baseline
for at least these 14 indicators where appropriate is available for 2015 so that it is
possible to monitor progress through the course of the strategy.
TABLE 2. INDICATORS FOR THE POST-2015 GLOBAL TECHNICAL STRATEGY
FOR MALARIA 20162030
OUTCOME
Proportion of population at risk who slept under an insecticide-treated net the

previous night
Proportion of population at risk protected by indoor residual spraying within the
past 12 months
Proportion of pregnant women who received at least three or more doses of
intermittent preventive treatment of malaria while attending antenatal care during
their previous pregnancy (sub-Saharan Africa only)
Proportion of patients with suspected malaria who receive a parasitological test
Proportion of patients with confirmed malaria who receive first-line antimalarial
treatment according to national policy
Proportion of expected health facility reports received at national level
Proportion of malaria cases detected by surveillance systems
Proportion of cases investigated (programmes engaged in elimination)
Proportion of foci investigated (programmes engaged in elimination)
IMPACT
Parasite prevalence: proportion of the population with evidence of infection with

malaria parasites
Malaria case incidence: number of confirmed malaria cases per 1000 persons
per year
Malaria mortality rate: number of malaria deaths per 100 000 persons per year
Number of countries that have newly eliminated malaria since 2015
Number of countries that were malaria-free in 2015 in which malaria was
re-established
ROLE OF THE SECRETARIAT

The Secretariat will continue to provide support to Member States and work closely
with organizations in the United Nations system, donors, intergovernmental organizations, institutions of research and academia and all other technical partners whose
work is fundamental to a successful implementation of this strategy. T
he Secretariat
will undertake the following activities to help to achieve global, regional and national
targets for malaria control and elimination.
The Secretariat will continue to set, communicate and disseminate normative guidance, policy advice and implementation guidance to support country action. It will
27
........................................................................................................
ensure that its policy-setting process which includes the Malaria Policy Advisory
Committee is responsive to the rapidly changing malaria context and that its global
technical guidance is regularly updated to incorporate innovative tools and strategies
that are proven effective. T
he Secretariat will continue to assess and pre-qualify vector control products, diagnostics and antimalarial medicines.
The Secretariat will provide guidance and technical support to Member States in
reviewing and updating their national malaria strategies in line with the priority
actions outlined in this strategy. It will ensure that its own capacities are strengthened
at the global, regional and country level to enable it to lead a coordinated global
effort to reduce the disease burden by at least 90% by 2030, and to support the
implementation of all recommendations in this strategy. It will work with Member
States to develop regional implementation plans, where appropriate.
The Secretariat will support countries in strengthening their national malaria surveillance systems in order to improve the quality, availability and management of
malaria data, and to optimize the use of such data for decision-making and programmatic responses. It will monitor implementation of the strategy and regularly
evaluate progress towards the milestones and goals set for 2020, 2025 and 2030. It
will also provide support to countries for developing nationally appropriate targets
and indicators to facilitate the subregional monitoring of progress.
In line with its core roles, the Secretariat will continue to monitor regional and global
malaria trends, and make these data available to countries and global malaria partners. It will support efforts to monitor the efficacy of medicines and vector control
interventions, and to this end maintain global databases for efficacy of medicines
and insecticide resistance. It will regularly report to the regional and global governing
bodies of the Organization, the United Nations General Assembly, and other United
Nations bodies.
WHO will promote the research and knowledge generation that is required to
accelerate progress towards a world free of malaria.
The strategy will be updated at regular intervals in order to ensure linkage with the
latest policy recommendations and complementary technical guidance.
28
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GLOBAL TECHNICAL STRATEGY AT A GLANCE

VISION A WORLD FREE OF MALARIA
GOALS
MILESTONES
TARGETS
2020
2025
2030
1. Reduce malaria mortality rates globally

compared with 2015
At least 40%
At least 75%
At least 90%
2. Reduce malaria case incidence globally

compared with 2015
At least 40%
At least 75%
At least 90%
3. Eliminate malaria from countries in which

malaria was transmitted in 2015
At least
10 countries
At least
20 countries
At least
35 countries
Re-establishment
prevented
Re-establishment
prevented
Re-establishment
prevented
4. Prevent re-establishment of malaria in

all countries that are malaria-free
PRINCIPLES
All countries can accelerate efforts towards elimination through combinations of interventions
tailored to local contexts.
Country ownership and leadership, with involvement and participation of communities, are essential
to accelerating progress through a multisectoral approach.
Improved surveillance, monitoring and evaluation, as well as stratification by malaria disease burden,
are required to optimize the implementation of malaria interventions.
Equity in access to health services especially for the most vulnerable and hard-to-reach populations
is essential.
Innovation in tools and implementation approaches will enable countries to maximize their
progression along the path to elimination.
STRATEGIC FRAMEWORK
comprising three major pillars, with two supporting elements: (1) innovation and research and
(2) a strong enabling environment
Maximize impact of todays life-saving tools
Pillar 1. Ensure universal access to malaria prevention, diagnosis and treatment
Pillar 2. Accelerate efforts towards elimination and attainment of malaria-free status
Pillar 3. Transform malaria surveillance into a core intervention
Supporting element 1. Harnessing innovation and expanding research
Basic research to foster innovation and the development of new and improved tools
Implementation research to optimize impact and costeffectiveness of existing tools and strategies
Action to facilitate rapid uptake of new tools, interventions and strategies
Supporting element 2. Strengthening the enabling environment
Strong political and financial commitments
Multisectoral approaches, and cross-border and regional collaborations
Stewardship of entire heath system including the private sector, with strong regulatory support
Capacity development for both effective programme management and research
29
global technical
strategy for
malaria 20162030
Global Technical Strategy for Malaria 20162030
ISBN 978 92 4 156499 1
Global Malaria Programme

World Health Organization
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1211 Geneva 27
Switzerland
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Global Technical Strategy for Malaria 20162030

ISBN 978 92 4 156499 1

Global Malaria Programme

WHO Library Cataloguing-in-Publication Data

(NLM classification: WC 765)

World Health Organization 2015

global technical strategy for malaria 20162030

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

NEED FOR A POST-2015 TECHNICAL

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

others have reduced transmission to low levels. T

slowed down, by several interconnected challenges. T

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

STRATEGY DEVELOPMENT PROCESS

VISION, GOALS AND PRINCIPLES

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

TABLE 1. GOALS, MILESTONES AND TARGETS FOR THE GLOBAL TECHNICAL

1. Reduce malaria mortality

2. Reduce malaria case

3. Eliminate malaria from

Re-establishment Re-establishment Re-establishment

PATH TO MALARIA ELIMINATION

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

THREE PILLARS OF THE STRATEGY

ponent of malaria control and elimination. T

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

Maintain adequate entomological surveillance and monitoring. To

Manage insecticide resistance and residual transmission. Even though

core vector control interventions continue to be effective in most areas, growing

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

Strengthen capacity for evidence-driven vector control. For effective

delivery and monitoring of vector control interventions, national malaria programmes

Implement malaria vector control in the context of integrated vector

taining adequate entomological surveillance and monitoring, managing insecticide

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

Protect all non-immune travellers and migrants. Chemoprophylaxis is the

Diagnostic testing and treatment

Provide quality-assured treatment to all patients. Ensuring universal

access to WHO-recommended antimalarial medicines is crucial in all settings in

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

Scale up community-based diagnostic testing and treatment. Training

Monitor safety and efficacy of antimalarial medicines and manage

the efficacy of antimalarial medicines are essential in order to detect unexpected

Contain antimalarial drug resistance. Protecting the efficacy of artemisinin-

Eliminate falciparum malaria from the Greater Mekong subregion.

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

Remove all inappropriate antimalarial medicines from markets. All

PILLAR 2. ACCELERATE EFFORTS TOWARDS ELIMINATION

Enact legislation. New legislation is needed in order to support changes in pro-

gramme prioritization, namely to ensure that the over-the-counter sale of antimalarial

Renew political commitment and deepen regional collaboration. The

final phase of elimination needs strong political commitment, predictable long-term

GLOBAL TECHNICAL STRATEGY FOR MALARIA 20162030

Reduce the number of undetected infections. Ensuring that malaria para-

Implement targeted malaria vector control. As transmission decreases to

low levels in countries or subnational areas, universal coverage of populations at risk