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M E D I C A T I O N A D M I N I S T R A T I O N
M A N U A L
MIDAZOLAM (VERSED)
ROUTES OF ADMINISTRATION
Direct IV Push, Continuous IV Infusion, IM
1. Management of agitation/anxiety
2. Adjunct to opioids for pain management
3. Planned Moderate Sedation/Analgesia (i.e. sedation for procedures in patients who are not
Moderate Sedation when used for moderate sedation/analgesia in patients who are
not intubated. For more information, refer to the policy and procedure for Moderate and
Deep Sedation (PC 228) in the Clinical Policy and Procedure Manual. The use of midazolam
as an adjunct to opioids for pain management and for the management of agitation/anxiety is
not considered to be planned moderate sedation/analgesia.
MONITORING PARAMETERS
1. CNS depression
2. Vital signs (respiratory rate, blood pressure, heart rate)
MIDAZOLAM (VERSED)
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L B M M C / P H A R M A C Y S E R V I C E S
M E D I C A T I O N A D M I N I S T R A T I O N
M A N U A L
1. Respiratory depression
2. Hypotension, arrhythmias, PVCs, bradycardia, tachycardia
3. Hiccups and coughing (4%), laryngospasm, bronchospasm, dyspnea, hyperventilation,
support), flumazenil (Romazicon) 0.2 mg IV over 15 seconds. May repeat 0.2 mg doses
every minute until desired consciousness level is achieved or total dose of 1 mg is reached. If
resedation occurs may repeat flumazenil dosage regimen every 20 minutes.
2. Hypotension: flumazenil (Romazicon) see dosage above, vasopressors.
COMMENTS
1. Facilities for administration of oxygen and controlled respiration should be readily available
REFERENCES
1.
2.
3.
4.
5.
Society of Critical Care Medicine and American Society of Health-System Pharmacists: Clinical Practice Guidelines for the Sustained Use
of Sedatives and Analgesics in the Critically Ill Adult. Am J Health-Syst Pharm. 2002;59:150-78.
American Hospital Formulary Service Drug Information 2001
Drug Facts and Comparisons St Louis Mo
Drugdex Micromedex, Inc.
Romazicon Product Information, Roche, Nutley, NJ
MIDAZOLAM (VERSED)
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