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Adam Hajduk
50
40
Women >65
Men > 65
Women > 85
Men > 85
30
20
10
0
2000
2010
2020
2030
2040
2050
Acute MI
Arrhythmias
Heart failure
Cerebrovascular disease
Total deaths
(in thousands)
78
17
42
65
Age > 65
68 (87.2%)
12 (70.6%)
37 (88.1%)
49 (75.4%)
Reduced ~ 50%
AV oxygen difference
Reduced ~ 25%
Cardiac output
Reduced ~ 25%
Heart rate
Reduced ~ 25%
LV stroke volume
No change or small
decrease
Increased ~ 150%
LV ejection fraction
Reduced ~ 15%
Stiff Vessel
Systole Diastole
Stroke Volume
Aorta
Resistance
Arterioles
Pressure (Flow)
Young Artery
Bentley Dw, Izzo JL. J Am Geriatr Soc. 1982; 30:352-359.
Arteriosclerotic Artery
Clinical Implications
10%
Female
5%
0%
25-44
45-54
55-64 65-74
75+
Age, years
Source: National Health and Nutrition Examination Survey
LV end-diastolic
pressure
< 65 years
80% of persons
6674 years 72%
> 75 years 49%
2. Heart failure (dyspnea, pulmonary oedema)
< 65 years 14 % of persons
6674 years 20 %
> 75 years 40 %
(Gregoratos, Am. J. Ger. Cardiol. 2001)
Some infarction cases remain unrecognised or recognised with substantial delay due to
atypical symptomatology.
(25% of ECG-recognised infarction cases were clinically undiagnosed Framingham
Study).
GUSTO-I
Delayed recognition of infarction in patients > 65 years is 2040
minutes
MITRA Register
Average delay > 75 years is 210 min. compared to 155 min. among
younger patients
(Haase KK i wsp. Clin Cardiol 2000,23)
atypical symptomatology
coexisting diseases (overlapping symptoms, misleading clinical
picture) and polypragmasy
difficulties in carrying out and interpreting diagnostic tests
hindered cooperation with a patient
ECG changes hindering diagnosis of ischemia
3. Exercise testing
Limited diagnostic value:
age-related changes in physiological response to exertion (reduction in aerobic
capacity, decrease in maximum heart rate 1/min/year, faster increase in systolic BP
value, limited increase in ejection fraction)
less intensive physical activity and bad physical condition (difficulties in reaching
target rate of 85% of the maximum predicted HR)
fast reaching of the target rate at a low stage of the exercise test
(initial tachycardia)
the ability to exercise is often limited by conditions unrelated to the heart (e.g.
arthritis, neurologic disorders balance disturbances, vertigo; peripheral vascular
disease)
elderly persons may not exercise maximally because of psychologic factors (e.g.
unfamiliarity with vigorous exercise and sophisticated medical equipment, fear,
insufficient motivation).
frequent abnormalities in resting ECG (LBBB, LV hypertrophy, pacemaker, drugs)
4. Perfusion scintigraphy
test useful in elderly population
abnormal Thallium-201 test result examined as the only parameter the
most sensitive indicator of the cardiac complications risk.
limitations similar to those of the exercise test (exertion may be replaced
with dipyridamole)
possibility of conducting isotopic ventriculography
(evaluation of LV function)
5. Stress echocardiography
exercise testing / pharmacologic stress testing with use of:
dobutamine, adenosine, dipyridamole
6. Coronarography
reference method (gold standard)
Vaccarino et al Ann of Int Med 2001; 134: 173-181. Solid lines are men; dotted lines
are women.
8%
15%
20%
30%
22%
5%
younger than 50
5059
6069
7079
8089
>90
Placebo
15%
Aspirin
10%
5%
0%
< 60
60-69
Age, years
70+
P < 0.00001
P < 0.00001
15%
Aspirin
10%
Control
5%
0%
< 65
65+
Age, years
Source: BMJ 1994;308:81-106
50-59
60-69
70-79
80-89
(n=461)
>90
80
70
60
50
40
30
20
10
0
<50
50-59
60-69
70-79
80-89
>90
90
80
70
60
50
40
30
20
10
0
<50
(n=62)
50-59
(n=96)
60-69
(n=107)
70-79
(n=117)
80-89
(n=69)
>90
(n=9)
Risk Stratification
ATRIAL FIBRILLATION
Prevalence:
5% of people over age 65
10% of people over age 80
CHADS2
CHF: 1 point
HA: 1 point
Age over 75: 1 point
DM: 1 point
Prior Stroke/TIA: 2 point
Benefit of Warfarin
Risks of Warfarin
Warfarin Use
HYPERTENSION
Hypertension - Prevalence
one of the in aging diseases
Mean Systolic and Diastolic BP by Age and Race/Ethnicity for Men and
Women (US Population Age 18 Years, NHANES III)
150
130
110
Non-Hispanic Black
Non-Hispanic White
Mexican American
SBP
(mm Hg)
SBP
(mm Hg)
150
110
DBP
(mm Hg)
80
70
70
0
150
150
SBP
(mm Hg)
130
110
130
110
Pulse pressure
80
Pulse pressure
80
DBP
(mm Hg)
SBP
(mm Hg)
DBP
(mm Hg)
80
DBP
(mm Hg)
130
70
0
80+
70
0
80+
systolic-diastolic hypertension:
27,630,3%
The Importance Of SH
to maintain SBP values < 140 and DBP < 90 mmHg, by diabetic
patients < 130 and < 85 mmHg respectively
the higher initial BP values are, the more carefully they should
be reduced
Treatment benefits
Dementia
Dementia (cont.)
Syst-Eur Study:
4700 patients > 60 years, treated for ISH (nitrendipine)
diagnosed dementia by 50%
(Alzheimers and vasogenic types)
PROGRESS Study
6150 patients with/without hypertension, history data: ischemic stroke
or TIA (perindopril /+indapamide);
dementia rate by 34%
stroke rate by 28%
Lifestyle Modifications
Modification
Approximate SBP
Reduction
(range)
Weight Reduction
5-10 mmHg/10kg
8-14 mmHg
2-8 mmHg
Physical activity
4-9 mmHg
Moderation of alcohol
consumption
24 mmHg
ACE inhibitors
Ca Channel Blockers
Which agent?
-blocker
consider consulting with a specialist
secondary hypertension
coexisting diseases
white-coat hypertension
Secondary hypertension
every sixth elderly patient with hypertension
Causes
alcohol abuse
Quality of Life
Orthostatic hypotonia
10% of physically fit and > 50% of infirm persons > 65 years
Pathomechanism
Postural
change
venous return
stroke volume
Predisposing factors
Management
raised-waist clothes
Conclusions