Professional Documents
Culture Documents
GOLGI COMPLEX
Located only in the cell body
Consists of multiple parallel arrays of smooth
cisternae arranged around the periphery of the
nucleus
Responsible for packaging of neurotransitter
substances
MITOCHONDRIA
Found in soma, dendrites & axon
Most abundant in axon terminals
More slender
Constantly moving along microtubules in the
cytoplasm
CENTRIOLE
Characteristic of preneuronal multiplying
cells during embryologic development
only occasionally encountered in adult
neurons
believed to be vestigial structures (because
neurons do not undergo cell division)
NEURONS
Functional unit of structure of nervous tissue
For receptive, integrative and motor functions of the
nervous system
5 150 um in diameter
NEUROGLIAL CELLS
For supporting and protecting neurons
Do not receive or transmit impulses
PARTS OF A NEURON
1. CELL BODY / PERIKARYON / SOMA
- Central portion which contains the nucleus &
perinuclear cytoplasm
in CNS:
- generally polygonal with concave surfaces
between many cell processes
in DRG (sensory ganglion of PNS):
- have a round cell body from which only 1
process exits
NUCLEUS
located
Prominent nucleolus
Contains finely dispersed chromatin
(may appear vesicular)
CYTOPLASM
NISSL BODIES
o stacked RER cisternae & polyribosomes
seen as clumps of basophilic material
o represent sites of protein synthesis
SER
Abundant, extends into the axons and
dendrites
- forms a broad, flat, fenestrated hypolemmal
cisterna
- sequester Ca and contain CHONs and
provide
a pathway for their distribution
throughout the cell
INCLUSIONS
A. Melanin coarse dark-brown/black granules
location:
- certain regions of the CNS (substantia nigra & locus
ceruleus, dorsal
motor nucleus of the
vagus
& spinal cord)
- sympathetic ganglia of the PNS
- thought to accumulate as by-product of the synthesis of
neurotransmitters dihydrophenylalanine or methyldopa
B. Lipofuscin golden-brown granules
- irregular in shape
- remnants of lysosomal enzymatic activity
- increase with advancing age, may even crowd
the organelles &
nucleus to one side possibly
affecting cellular function
Purkinje cells of cerebellar cortex
Iron containing pigments
C. Lipid droplet result of faulty metabolism or normal
energy reserves
D. Secretory granules
- observed in neurosecretory cells
- many contain signaling molecules
CYTOSKELETAL COMPONENTS
microtubules
- 20 28 nm in diameter
- essential role in transport of vesicles &
organelles that move along their
surface w/in the
cell body & along the length of the axon
neurofilaments
- intermediate, 10 nm in diameter
- abundant in perikaryons & cell processes
microfilaments
- 6 nm in diameter
2. DENDRITE
- cell body projections
-with abundant mitochondria
- receives stimuli from sensory cells, axons and other
neurons
- impulse received are transmitted towards soma
MECHANISM OF MYELINATION
- Schwann cell (or oligodendrocytes) concentrically
wraps its membrane around the axon to form the myelin
sheath
- wrapping may continue for more than 50 turns
- cytoplasm is squeezed back into the body of the
Schwann cell bringing the cytoplasmic surfaces of the
membranes in contact with each other forming the major
dense line that spirals through the myelin sheath
PERIPHERAL NERVE SHEATHS
EPINEURIUM
outermost sheath
envelops the nerve & sends extensions into it to
surround the separate nerve fascicles w/in it
thick & strong investment composed of dense
irregular connective tissue
PERINEURIUM
covers each bundle of nerve fiber (fascicle)
more dense; consists of a few to several layers
of flattened fibroblast-like cells bounded both
internally & externally by a basal lamina
ENDONEURIUM
surround individual nerve fibers (axons)
delicate, loose connective tissue consisting of
small fibrils of collagen, fibroblasts, fixed
macrophages, capillaries, perivascular mast
cells, & EC fluid
Classification of NEURONS
A.
ACCORDING TO MORPHOLOGY:
BIPOLAR
posses 2 processes emanating from the soma, a
single dendrite and a single axon
found in the vestibular & cochlear ganglia & in
the olfactory epithelium of the nasal cavity
PSEUDOUNIPOLAR
when a single process, morphologically an axon,
leaves the body and soon bifurcates
BRANCHES:
A. peripheral proceeds to its destination in the
body
B. central enters the CNS
B. CHEMICAL
impulse transmission occur mostly through the
release of neurotransmitters at axon terminal
Components:
A. Presynaptic membrane
B. Synaptic cleft
small gap between that separates the
pre- & postsynaptic membranes
12-20 nm
may contain polysaccharides & some
fine intersynaptic filaments
Postsynaptic membrane
ELECTRICAL
Uncommon
Few places in the brain stem, retina & cerebral
cortex
Transmission is much more rapid
Transmit impulse through gap junctions that
cross the pre- & postsynaptic membranes
Ions pass freely through these gap junctions
UNIPOLAR
posses only 1 PROCESS emanating from the
cell body
exists in early embryonic life
ACCORDING TO FUNCTION:
Synaptic
vesicles
contain
neurotransmitters, fill the bouton
A.
NEUROGLIAL CELLS
1. Astrocytes
chemical
o
o
o
o
o
o
o
o
Location
Types of Astrocytes
A. Protoplasmic
o many short branching processes
o abundant cytoplasm & bigger & palerstaining nucleus
o found mainly within the gray matter
B. Fibrous
o with few long processes mostly unbranched
o closely associated with the pia mater &
blood vessels
o located chiefly in the white matter
o possess euchromatic cytoplasm containing
only a few organelles, free ribosomes, &
glycogen
2. Oligodendrocytes
o smaller, fewer & shorter processes
o scanty cytoplasm & smaller ovoid/spherical
nucleus
o located in the white matter where they form the
myelin sheath
3. Microglia
o Dense elongated nuclei
o small cell with short processes
o cytoplasm scanty & contains many lysosomes
o phagocytic in nature
o Represent the mononuclear phagocytic system
in nervous tissue & derived from precursor cells
in the bone marrow
o Involved with inflammation & repair in the adult
CNS
o produce & release neutral proteases & oxidative
radicals
4. Ependyma
o Low columnar to cuboidal epithelial cells that
line the cavities of the CNS
o posses short cytoplasmic processes, free
surface possesses microvilli
o cytoplasm contains abundant mitochondria and
bundles of intermediate filaments
o some are ciliated, a feature that facilitates the
movement of CSF
5. Schwann cells
Schwann Cell
Astrocyte
Neural ectodermPeripheral
Nerves
Neural ectodermCNS
Mesoderm
CNS
Main Functions
Myelin production,
Electric insulation
Myelin production,
Electric insulation
Structural support,
Repair processes,
BBB,
Metabolic
exchanges
Lining cavities of
central
nervous
system
Macrophagic
activity
by
special
Proximal portion of the injured axon undergoes
degeneration followed by sprouting of a new axon whose
growth is directed by Schwann cells
SER
CNS
GRAY MATTER
- contains neuronal cell bodies, dendrites & the
initial unmyelinated portions of axons & glial cells
- Region where synapses occur
- Prevalent at surface of cerebrum & cerebellum
- Nuclei aggregates of neuronal cell bodies
forming islands of gray matter embedded in the white
matter
Nissl Bodies
clumps of intensely chromatophilic
material
consist of cisternae of granular ER
in ordered parallel array
ribosomes are arranged in rows,
loops & spirals on the outer surface
of the cisternae
CNS
WHITE MATTER
contains the myelinated axons & the myelin
producing oligodendrocytes
it does not contain neuronal cell bodies
the myelin sheath imparts the white color
Axon Hillock
Parts of a NEURON
NUCLEUS
spherical/ovoid
with
unusually
large,
euchromatic (pale
staining) nucleus with
prominent nucleolus
Nerve Processes
DENDRITES
Provide the surface for receiving signals from
other neurons
Relatively thick but taper gradually along their
length
Fairly short & confined to the immediate vicinity
of the soma
Bifurcate, at acute angles, into primary,
secondary, tertiary & higher orders of branches
Found abundant in nerve cells (considerably
increase the receptive area of the cell)
C. AXONS
All axons originate from a short pyramidshaped region, the Axon hillock, that usually
arises from the perikaryon
AXON
CELL TYPES
Nerve cells or neurons - show numerous long processes
a. Glial cells
- have short processes
- support & protect neurons
- participate in neural activity, neural nutrition, &
defense processes of the CNS
b. PERIKARYON OR CELL BODY
1. ORGANELLES
Abundant
extends into the axons & dendrites
forms a broad, flat, fenestrated
hypolemmal cisterna
sequester Ca & contain CHONs &
provide a pathway for their
distribution throughout the cell
transport vesicles & synaptic
vesicles may bud off from it
SOMATIC SYSTEM
QUIZ!!
identify picture shown: fibrous astocyte
(answer)
2. identify: perineurium
1.
3.
4.
5.
6.
7.
8.
9.
10.