University of Zagreb School of Medicine

Plan of the course

Immunology
Academic year 2013/14

Course coordinators:
Professor Dora Vinji, MD, PhD
Assistant Professor Vesna Lukinovi-kudar, MD, PhD
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The course is intended to provide important and recent knowledge of cellular and molecular immunology. Students
will be presented large amount of complex information within three weeks; therefore, the main aim is to teach basic
concepts of experimental immunology, which are also applicable in a clinical setting. The extensive additional
reading will be provided for students who would like to learn more about immune system function in health and
disease.
Lectures will be focused on important concepts of immune system function in physiological and pathological
conditions. Seminars will include interactive discussion, as well as the presentation of clinical cases, in order to
present complex mechanisms of immune response in a clear and understandable way. Practical part of the course will
be performed in small groups to allow students to acquire lab-work skills related to some commonly used
immunological techniques.

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Lectures
Seminars
Practicals

7 (total 9 hours)
12 (total 26 hours)
3 (total 15 hours)

Total

50 hours

WEEK 1
TYPE
Lectures

Seminars

Practicals

TOPIC (duration)
Chapter
Introduction to immunology (45 min)
Organization of the immune system (245 min)
Innate immunity (2x45 min)
Antigen processing and presentation (45 min)
Antibody structure and the generation of B cell diversity (2x45)
Ch 4
Development of B lymphocytes (45)
Ch 6
Humoral immunity (345 min)
Ch 9
Preparation of cell suspension, Immunoflurescence staining, Flow-cytometric analysis (6x45
min)

WEEK 2
TYPE
Lectures

Seminars

Practicals

TOPIC (duration)
Chapter
Regulation of the immune response (45 min)
Cytokines (45 min)
Immunological tolerance (45 min)
Antigen recognition by T lymphocytes (45 min)
Ch 5 (125-132)
Development of T lymphocytes (45 min)
Ch 7
Cellular immunity (345 min)
Ch 8
Autoimmunity (345 min)
Ch 13
Application of immunological techniques in clinical medicine (345)

WEEK 3
TYPE
Lectures
Seminars

Practical

TOPIC (duration)

Chapter

Immunodeficiency (245 min)

Hypersensitivity (345 min)
Histocompatibility.Transplantation (345 min)
Tumor immunology (245 min)
Immunity to infections. Vaccination (2x45 min)
Blood groups. Differential. (645 min)

Ch 11
Ch 12
Ch 5 (145-154), Ch 15
Ch 16
Ch 10,14

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WEEK 1
Day

Time

Type

Group

Topic

Faculty

Monday
7.4.14.
9.00-9.45

L (M)

A+B

Introduction to immunology

10.00-11.30

L (M)

A+B

Organization of the immune system

12.00-13.30

L (M)

A+B

Innate immunity

Wednesday

8.00-12.30

Preparation of cell suspension, immunofluor. staining, FACS

9.4.14.

13.00-17.30

Preparation of cell suspension, immunofluor. staining, FACS

8.00-9.30

S (M)

Antibody structure and the generation of B cell diversity

10.00-10.45

L (M)

A+B

11.00-12.30

S (M)

Antibody structure and the generation of B cell diversity

8.00-8.45

S (M)

Development of B lymphocytes

Friday

9.00-11.15

S (M)

Humoral immunity

11.4.14.

11.30-12.15

S (M)

Development of B lymphocytes

12.30-14.45

S (M)

Humoral immunity

Tuesday
8.4.14.

Thursday
10.4.14.

Antigen processing and presentation

WEEK 2
Day

Time

Type

Group

Topic

Faculty

8.00-8.45

S (M)

Antigen recognition by T lymphocytes

9.00-9.45

S (M)

Development of T lymphocytes

14.00-16.15

P*

Application of immunological techniques in clinical medicine

8.00-8.45

S (M)

Antigen recognition by T lymphocytes

9.00-9.45

S (M)

Development of T lymphocytes

14.00-16.15

P*

Application of immunological techniques in clinical medicine

Wednesday

8.00-10.15

S (M)

Cellular immunity

16.4.14.

10.30-12.45

S (M)

Cellular immunity

8.00-8.45

L (W)

A+B

Regulation of the immune response

9.00-9.45

L (W)

A+B

Cytokines

10.00-10.45

L (W)

A+B

Immunological tolerance

Friday

8.00-10.15

S (M)

Autoimmunity

18.4.14.

10.30-12.45

S (M)

Autoimmunity

Monday
14.4.14.

Tuesday
15.4.14.

Thursday
17.4.14.

WEEK 3
Day

Time

Monday

Type

Group

Topic

Faculty

EASTER

21.4.14.
Tuesday

8.00-9.30

S (NV)

Immunodeficiency

22.4.14.

10.00-12.15

S (NV)

Hypersensitivity

10.45-12.15

S ()

Immunodeficiency

12.45-15.00

S (NV)

Hypersensitivity

Wednesday

8.00-10.15

S (M)

Histocompatibility. Transplantation.

23.4.14.

13.00-17.30

Blood groups. Differential.

Thursday

8.00-10.15

S (M)

Histocompatibility. Transplantation

24.4.14.

13.00-17.30

Blood groups. Differential.

8.00-9.30

S (M)

Tumor immunology

10.00-11.30

S (M)

Immunity to infections. Vaccination.

12.00-13.30

S (M)

Tumor immunology.

14.00-15.30

S (M)

Immunity to infections. Vaccination.

Friday
25.4.14.

L-lecture, S-seminar, P-practical, M-Masek Room, W Wickerhauser Room, NV- Nova vijecnica, - akovi
Room
The practical (P*) Application of immunological techniques in clinical medicine will be held at the Immunology
Laboratory, Rebro University Hospital, Kipatieva 12 (Prof. Drago Batini)
All other practicals will be held at the Lab, Department of Physiology.

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Final examination (written+oral) will be organized at the end of the course (Friday, 3.5.2013., 8.00 Cackovic
Room) and several times thereafter, within the academic year. Written exam (test) will include 40 multiple-choice
questions. Students need to answer at least 55% of the questions correctly to pass the written exam and to qualify for
taking the oral examination. Students seminar work and presentation will be evaluated and included in the final
score (maximum 10% of total points). The final oral examination determines the final mark of the course.

Regular terms
Winter
Summer
Autumn

Date
2.5.2014.
8.7.2014.
22.7.2014.
9.9.2014.
23.9.2014.

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Professor Drago Batini, MD, PhD
Vilma Dembitz, MD
Assistant Professor Tomislav Kelava, MD, PhD
Hrvoje Lali, MD
Assistant Professor Vesna Lukinovi-kudar, MD, PhD
Alan uur, MD
Professor Dora Vinji, MD, PhD
Professor Mirza iak, MD, PhD

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VVVV A

Parham Peter. The Immune System, Third Edition, New York-London,

Garland Science, Taylor & Francis Group, 2009.
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Delves PJ. Martin SJ, Burton DR, Roitt IM, Roitt's Essential Immunology, 12th edition. Wiley-Blackwell,
2011.
Abbas AK, Lichtman H, Pallai S. Cellular and molecular immunology, 7th edition, Philadelphia Saunders,
2011.
Murphy K. Janeway's Immunobiology, 8th edition. New York: Garland Publishing; 2011.
Geha RS, Rosen FS. Case studies in immunology: A clinical companion, 5th edition. New York: Garland
Publishing; 2007.
Johnson AG, Ziegler RJ, Hawley LB. Microbiology & Immunology: Board Review Series, 5th edition.
Philadelphia: Lippincott Williams & Wilkins; 2009.