Professional Documents
Culture Documents
Management
of Patients With
Unstable Angina/
NonST-Elevation
Myocardial
Infarction
(Adapted from the 2007
ACCF/AHA Guideline and the
2011 ACCF/AHA Focused Update)
Initial E/M
Hospital Care
Association (my.americanheart.org).
For a copy of the full report or published executive summary, visit
ACC/AHA 2007 Guidelines for the Management of Patients With
Unstable Angina/NonST-Elevation Myocardial Infarction (J Am
Coll Cardiol 2007;50:e1-e157) and the 2011 ACCF/AHA Focused
Discharge/Post-Discharge
Revascularization
department at healthpermissions@elsevier.com.
Contents
1. Introduction.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Initial E/M
A. Clinical Assessment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
13
Hospital Care
A. Anti-Ischemic Therapy.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
D. Risk Stratification. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
30
A. Medical Regimen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
B. Convalescent and Long-Term Medical Therapy and
Secondary Prevention (UPDATED). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Discharge/Post-Discharge
5. Coronary Revascularization
Revascularization
1. Introduction
Coronary artery disease is the leading cause of death
in the United States. Unstable angina (UA) and the closely
related condition nonST-segment elevation myocardial
infarction (MI) (NSTEMI) are very common manifestations of
this disease and are responsible for approximately 1.5 million
hospitalizations in the United States each year. UA and NSTEMI
are examples of acute coronary syndrome (ACS), which is
characterized by an imbalance between myocardial oxygen
supply and demand. The most common cause is the reduced
myocardial perfusion that results from coronary artery
narrowing caused by a nonocclusive thrombus that has
developed on a disrupted atherosclerotic plaque. UA and
NSTEMI are considered to be closely related conditions whose
pathogenesis and clinical presentations are similar but of
differing severity; they differ primarily in whether the ischemia
is severe enough to cause sufficient myocardial damage to
release detectable quantities of a marker of myocardial injury.
The customary American College of Cardiology Foundation/
American Heart Association (ACCF/AHA) classification of
recommendations and levels of evidence is used and displayed
in Table 1.
Discharge/Post-discharge
of
T reatment
E s t i m a t e o f C e r t a i n t y ( P r ec i s i o n ) o f T r ea t m e n t E ffec t
Hospital Care
Class I
E f f ect
Class IIa
Procedure/Treatment
should be performed/
administered
n Recommendation that
procedure or treatment
is useful/effective
n Recommendation in favor
of treatment or procedure
being useful/effective
Level B
n Recommendation that
procedure or treatment
is useful/effective
n Recommendation in favor
of treatment or procedure
being useful/effective
n Recommendation that
procedure or treatment is
useful/effective
n Recommendation in favor
of treatment or procedure
being useful/effective
should
is recommended
is indicated
is useful/effective/beneficial
is reasonable
can be useful/effective/beneficial
is probably recommended or indicated
Comparative
effectiveness phrases
treatment/strategy A is probably
recommended/indicated in preference
to treatment B
it is reasonable to choose treatment A
over treatment B
Level A
Multiple populations
evaluated*
Limited populations
evaluated*
Data derived from a
single randomized
trial or nonrandomized
studies
Level C
Very limited populations
evaluated*
Only consensus opinion
of experts, case studies,
or standard of care
Benefit Risk
Additional studies with broad
objectives needed; additional
registry data would be helpful
Procedure/Treatment
may be considered
Recommendations
usefulness/efficacy less
well established
n
Greater conflicting
evidence from multiple
randomized trials or
meta-analyses
n
Recommendations
usefulness/efficacy less
well established
n
Greater conflicting
evidence from single
randomized trial or
nonrandomized studies
n
Recommendations
usefulness/efficacy less
well established
n
Procedure/
Test
Recommendation that
procedure or treatment is
not useful/effective and
may be harmful
n
Recommendation that
procedure or treatment is
not useful/effective and
may be harmful
effective.
Recommendation that
procedure or treatment is
not useful/effective and
may be harmful
COR III:
Harm
potentially
harmful
causes harm
associated with
excess morbidity/mortality
should not
be done
Discharge/Post-DIscharge Care
may/might be considered
may/might be reasonable
usefulness/effectiveness is
unknown /unclear/uncertain or
not well established
Introduction
Class IIb
Initial E/M
Initial E/M
Class IIa
01
4.7
8.3
13.2
19.9
26.2
67
40.9
Initial E/M
All-Cause Mortality, New or Recurrent MI,
or Severe Recurrent Ischemia Requiring
Urgent Revascularization Through 14 d
TIMI Risk Score After Randomization, %
The TIMI risk score is determined by the sum of the presence of 7 variables at admission;
1 point is given for each of the following variables:
age 65 y or older;
at least 3 risk factors for CAD;
n prior coronary stenosis of 50% or more;
n ST-segment deviation on ECG presentation;
n at least 2 anginal events in prior 24 h;
n use of aspirin in prior 7 d;
n elevated serum cardiac biomarkers.
n
n
Prior coronary stenosis of 50% or more remained relatively insensitive to missing information
and remained a significant predictor of events.
Reprinted with permission from Antman EM, Cohen M, Bernink PJ, et al. The TIMI risk score for unstable angina/
non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA 2000; 284:835-42.
Copyright 2000 American Medical Association.
CAD indicates coronary artery disease; ECG, electrocardiogram; MI, myocardial infarction.
Initial E/M
Medical History
1 Age in Years
Points
29..................................... 0
30-39................................... 0
40-49................................. 18
50-59................................. 36
60-69................................. 55
70-79................................. 73
80-89................................. 91
90................................. 100
Findings
During Hospitalization
4 Resting Heart
Points
Rate, beats/min
49.9................................ 0
50-69.9..............................3
70-89.9..............................9
90-109.9..........................14
110-149.9........................23
150-199.9........................35
200...............................43
2 History of Congestive
Heart Failure....................... 24
3 History of
Myocardial Infarction.......... 12
mm HG
79.9.............................. 24
80-99.9............................22
100-119.9........................18
120-139.9........................14
140-159.9........................10
160-199.9..........................4
200.................................0
7 Initial Serum
Creatinine, mg/dL
Points
0-0.39............................... 1
0.4-0.79............................ 3
0.8-1.19............................ 5
1.2-1.59............................ 7
1.6-1.99............................ 9
2-3.99............................. 15
4.................................. 20
8 Elevated Cardiac
Enzymes......................... 15
9 No In-Hospital
Percutaneous
Coronary Intervention...... 14
6 ST-Segment Depression... 11
Predicted All-Cause Mortality From Hospital Discharge to 6 Months
Points
0.50
0.45
0.40
0.35
Probability
4
5
6
7
0.10
9
Mortality Risk
0.25
0.20
0.15
8
Total Risk Score
0.30
0.05
(Sum of Points)
(From Plot)
70
90
110
130
150
Total Risk Score
170
190
210
Eagle KA, Lim MJ, Dabbous OH, et al. A validated prediction model for all forms of acute coronary syndrome: estimating
the risk of 6-month post-discharge death in an international registry. JAMA 2004; 291:2727-33. Copyright 2004 American
Medical Association.
10
C. Immediate Management
Recommendations
Class I
11
Initial E/M
symptoms, positive cardiac biomarkers, new STsegment deviations, new deep T-wave inversions,
hemodynamic abnormalities, or a positive stress test
should be admitted to the hospital for further
management. Admission to the critical care unit is
recommended for those with active, ongoing
ischemia/injury and hemodynamic or electrical
instability. Otherwise, a telemetry step-down unit is
reasonable. (Level of Evidence: C)
5. Patients with possible ACS and negative cardiac
biomarkers who are unable to exercise or who have
an abnormal resting ECG should undergo a
pharmacological stress test. (Level of Evidence: B)
6. Patients discharged from the ED or chest pain unit
should be given specific instructions for activity,
medications, additional testing, and follow-up with a
personal physician. (Level of Evidence: C)
12
Initial E/M
Class I
13
Hospital Care
14
Class IIa
15
Hospital Care
Class IIb
Hospital Care
16
Patient Characteristics
Generally preferred Recurrent angina or ischemia at rest or with lowlevel activities despite intensive medical therapy
Elevated cardiac biomarkers (TnT or TnI)
Hemodynamic instability
PCI within 6 mo
Prior CABG
Diabetes mellitus
Hospital Care
CABG indicates coronary artery bypass graft surgery; GRACE, Global Registry of Acute Coronary Events; HF,
heart failure; LVEF, left ventricular ejection fraction; PCI, percutaneous coronary intervention; TIMI, Thrombolysis in
Myocardial Infarction; TnI, troponin I; and TnT, troponin T.
17
Hospital Care
History
Character of pain
Prolonged ongoing (>20 min) rest pain
Clinical findings
ECG
Cardiac markers
Elevated cardiac TnT, TnI, or CK-MB
(e.g., TnT or TnI >0.1 ng per mL)
*Estimation of the short-term risks of death and nonfatal cardiac ischemic events in UA (or NSTEMI) is a complex multivariable problem that cannot be fully specified in a table such as this; therefore, this table is meant to
offer general guidance and illustration rather than rigid algorithms.
Adapted from AHCPR Clinical Practice Guidelines No.10, Unstable Angina: Diagnosis and Management, May 1994.
18
Intermediate Risk
No high-risk feature, but must have
1 of the following:
Low Risk
No high- or intermediate-risk feature
but may have any of the following features:
Hospital Care
T-wave changes
Pathological Q waves or resting
ST-depression <1 mm in multiple
lead groups (anterior, inferior, lateral)
19
Hospital Care
*If fondaparinux is
used with an invasive
strategy (Class I,
LOE: B), it must be
coadministered with
another anticoagulant
with Factor IIa activity,
for example, UFH.
ASA indicates aspirin; CABG, coronary artery bypass graft; D/C, discontinue; GP, glycoprotein; IV,
intravenous; LOE, level of evidence; PCI, percutaneous coronary intervention; STEMI, ST-elevation
myocardial infarction; UA/NSTEMI, unstable angina/non-ST-elevation myocardial infarction; and UFH,
unfractionated heparin.
20
Invasive Strategy
CABG:
Maintenance ASA
(Class I, LOE: A)
PCI:
Class I:
Clopidogrel (if not begun precatheterization) (LOE: A) or
Prasugrel (LOE: B) or
Selectively, a GP IIb/IIIa
inhibitor (if not begun
precatheterization) (LOE: A)
Medical
Therapy: D/C
GP IIb/IIIa
inhibitors if
begun and give
clopidogrel per
conservative
strategy
Hospital Care
ASA indicates aspirin; CABG, coronary artery bypass graft; D/C, discontinue; GP, glycoprotein; IV, intravenous; LOE,
level of evidence; PCI, percutaneous coronary intervention; STEMI, ST-elevation myocardial infarction; UA/NSTEMI,
unstable angina/non-ST-elevation myocardial infarction; and UFH, unfractionated heparin.
21
CABG
Continue ASA*
(Class I, LOE: A)
Hospital Care
Discontinue clopidogrel at
least 5 d (Class I, LOE: B)
and prasugrel at least 7 d
(Class I, LOE: C) prior to
elective CABG
Discontinue IV GP IIb/IIIa
4 h prior to CABG
(Class I, LOE: B)
Continue UFH (Class I,
LOE:B); discontinue enoxaparin 12 to 24 h prior to
CABG; discontinue fondaparinux 24 h prior to CABG;
Discontinue bivalirudin 3 h
prior to CABG. Dose with
UFH per institutional
practice (Class I, LOE: B)
* See Dosing Table 5.
PCI
Continue ASA*
(Class I, LOE: A)
LD of a
thienopyridine if
not given pre angio
(Class I, LOE: B)*
and it is reasonable
to give IV GP IIb/
IIa if not started pre
angio (Class IIa,
LOE: A)*
Discontinue anticoagulant after PCI
for uncomplicated
cases
(Class I, LOE: B)
Medical therapy
No
significant
obstructive
CAD on
angiography
Antiplatelet and
anticoagulant
therapy at
physicians
discretion
(Class I, LOE: C)
CAD on angiography
Continue ASA*
(Class I, LOE: A)
LD of clopidogrel if not
given pre angio
(Class I, LOE: B)*
Discontinue IV GP IIb/IIIa
after at least 12 h if started
pre angio (Class I, LOE: B)
Continue IV UFH for at
least 48 h (Class I, LOE: A)
or enoxaparin or
fondaparinux for duration
of hospitalization (Class I,
LOE: A); either discontinue
bivalirudin or continue at a
dose of 0.25 mg/kg/hr for
up to 72 h at physicians
discretion (Class I, LOE: B)
Evidence exists that GP IIb/IIIa inhibitors may not be necessary if the patient
received a preloading dose of at least 300 mg of clopidogrel at least 6 h earlier (Class I, LOE: B for clopidogrel
administration) and bivalidrudin is selected as anticoagulant (Class IIa, LOE: B).
Additional bolus of UFH is recommended if fondaparinux is selected as anticoagulant (see Dosing Table 5).
For patients in whom the clinician believes coronary atherosclerosis is present, albeit without any significant,
flow-limiting stenosis, long-term treatment with antiplatelet agents and other secondary prevention measures
should be considered.
ASA indicates aspirin; CABG, coronary artery bypass graft; CAD, coronary artery disease; GP, glycoprotein;
IV, intravenous; LD, loading dose; PCI, percutaneous coronary intervention; pre angio, before angiography;
UA/NSTEMI, unstable angina/nonST-elevation myocardial infarction; UFH, unfractionated heparin.
22
UA/NSTEMI Patient
Groups at Discharge
Hospital Care
Drug-Eluting Stent
Group
Bare-Metal Stent
Group
Medical Therapy
Without Stent
No
Continue with dual antiplatelet
therapy as above
* For ASA allergic patients, use clopidogrel alone (indefinitely), or try ASA desensitization.
For clopidogrel allergic patients, use ticlopidine, 250 mg by mouth twice daily, or prasugrel.
Continue ASA indefinitely and warfarin longer term as indicated for specific conditions such as atrial fibrillation;
LV thrombus, cerebral, venous or pulmonary emboli.
When risk of bleeding is a concern, a lower initial ASA (75 to 162 mg/d) after PCI is reasonable
23
During PCI
Drug*
Of uncertain benefit
Hospital Care
Eptifibatide
Of uncertain benefit
Tirofiban
Of uncertain benefit
LD of 25 mcg/kg IV bolus
MD of IV infusion of 0.15 mcg/kg per min; reduce
rate of infusion by 50% in patients with estimated
creatinine clearance <30 mL/min (Class I, LOE: B)
Thienopyridines
Clopidogrel
Prasugrel
LD of 60 mg orally
MD of 10 mg orally per d (Class I, LOE: B)
24
Comments
All Patients to Receive ASA (162325 mg)
A LD of eptifibatide is FDA approved when the medication is initiated in UA/NSTEMI patients who
are started on medical therapy and when there is an appreciable delay in angiography/PCI: LD of
180 mcg/kg IV bolus followed by MD of 2.0 mcg/kg per min started after bolus reduce infusion
by 50% in patients with estimated creatinine clearance <50 mL/min (Class I, LOE: B)
Infusion should be continued for 12 to 18 h at the discretion of the physician.
Hospital Care
25
During PCI
Drug*
Parenteral Anticoagulants
For patients who have
received UFH, wait 30
min, then give 0.75
mg/kg bolus, then 1.75
mg/kg per h infusion
(Class I, LOE: B)
UFH
IV GP IIb/IIIa planned:
target ACT 200250 s
No IV GP IIb/IIIa
planned: target
ACT 250300 s for
HemoTec, 300350 s
for Hemochron
(Class I, LOE: B)
Hospital Care
Bivalirudin
* This list is in alphabetical order and is not meant to indicate a particular therapy preference. This drug table does not
make recommendations for combinations of listed drugs. It is only meant to indicate an approved or recommended
dosage if a drug is chosen for a given situation.
For
post-PCI patients receiving a DES or BMS, a daily MD should be given for at least 12 mo unless the risk of bleeding
outweighs the anticipated net benefit afforded by a thienopyridine. The necessity for giving an LD of clopidogrel before
PCI is driven by the pharmacokinetics of clopidogrel, for which a period of several hours is required to achieve desired
levels of platelet inhibition. Patients who have a reduced-function CYP2C19 allele have significantly lower levels of the
active metabolite of clopidogrel, diminished platelet inhibition, and a higher rate of MACE, including stent thrombosis. In
NSTEMI patients taking clopidogrel for whom CABG is planned and can be delayed, it is reasonable to discontinue the
clopidogrel to allow for dissipation of the antiplatelet effect unless the urgency for revascularization and/or the net benefit
of clopidogrel outweigh the potential risks of excess bleeding. The period of withdrawal should be at least 5 d in patients
receiving clopidogrel.
26
Comments
All Patients to Receive ASA (162325 mg)
Bivalirudin may be used to support PCI and UA/NSTEMI with or without previously administered
UFH with the addition of 600 mg of clopidogrel.
In UA/NSTEMI patients undergoing PCI who are at high risk of bleeding, bivalirudin anticoagulation is reasonable.
Hospital Care
Patients
weighing <60 kg have an increased exposure to the active metabolite of prasugrel and an increased risk of
bleeding on a 10-mg once-daily MD. Consider lowering the MD to 5 mg in patients who weigh <60 kg. The effectiveness
and safety of the 5-mg dose have not been studied prospectively. For post-PCI patients receiving a DES or BMS, a daily
MD should be given for at least 12 and up to 15 mo unless the risk of bleeding outweighs the anticipated net benefit
afforded by a thienopyridine. Do not use prasugrel in patients with active pathological bleeding or a history of TIA or
stroke. In patients 75 years of age, prasugrel is generally not recommended because of the increased risk of fatal and
intracranial bleeding and uncertain benefit, except in high-risk situations (patients with diabetes or a history of prior MI),
for which its effect appears to be greater and its use may be considered. Do not start prasugrel in patients likely to undergo urgent CABG. When possible, discontinue prasugrel at least 7 d before any surgery. Additional risk factors for bleeding
include body weight <60 kg, propensity to bleed, concomitant use of medications that increase the risk of bleeding (e.g.,
warfarin, heparin, fibrinolytic therapy, or long-term use of nonsteroidal anti-inflammatory drugs).
ACT indicates activated clotting time; BMS, bare-metal stent; GP, glycoprotein; IU, international unit; IV, intravenous;
LD, loading dose; MD, maintenance dose; PCI, percutaneous coronary intervention; PES, paclitaxel-eluting stent; SC,
subcutaneous; SES, sirolimus-eluting stent; U, units; UA/NSTEMI, unstable angina/nonST-elevation myocardial infarction;
UFH, unfractionated heparin.
27
D. Risk Stratification
Recommendations
Class I
Hospital Care
29
A. Medical Regimen
An effort of the entire staff (physicians, nurses, dietitians,
pharmacists, rehabilitation specialists, and physical and
occupational therapists) is often necessary to prepare the
patient for discharge. Direct patient instruction is important and
should be reinforced and documented with written instruction
sheets. Enrollment in a cardiac rehabilitation program after
Discharge/Post-Discharge
Recommendations
Class I
30
Discharge/Post-Discharge
Class I
Discharge/Post-Discharge
32
33
Class IIa
Class IIb
Class III:
Harm
2. Beta Blockers
Class I
Revascularization
Discharge/Post-Discharge
34
Class I
35
Class IIa
4. Nitroglycerin
Class I
Class I
Revascularization
Discharge/Post-Discharge
Class I
36
Class IIb
7. Lipid Management
Class I
37
Class IIa
Revascularization
Discharge/Post-Discharge
38
Class I
Class I
Discharge/Post-Discharge
Class I
Revascularization
Discharge/Post-Discharge
* There is uncertainty about the ideal target range for glucose necessary to achieve an optimal
risk-benefit ratio.
40
Class IIa
Class I
Class I
Discharge/Post-Discharge
Class I
Revascularization
Discharge/Post-Discharge
Class I
42
15. Influenza
Class I
16. Depression
Class IIa
Class III
Discharge/Post-Discharge
Class IIa
Revascularization
Discharge/Post-Discharge
NSTEMI.(Level of Evidence: B)
44
5. Coronary Revascularization
ee 2011 Percutaneous Coronary Intervention and
S
Coronary Artery Bypass Graft Surgery Guidelines
for the most current recommendations on
revascularization.
Revascularization
45
46