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HUMAN
GENETICS
Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, 685000 Russia;
fax: (41322)34-463; e-mail: ibpn@online.magadan.su
2 Meshhed University, Meshhed, Iran
3 National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 113152 Russia
Received June 27, 2001
AbstractMitochondrial DNA (mtDNA) restriction polymorphism was examined in Turkmens, Eastern Iranians, and Ukrainians. The gene pools of all populations studied were characterized by the presence of European mtDNA lineages. Mongoloid component observed in Turkmen and Iranian populations with the frequencies of about 20% was represented by groups C, D, and E/G in Turkmens, and by M*, D, A, and B in Iranians.
The relative positions of the populations studied, of populations from the Caucasus, Western Iran, and Russian
populations from the Krasnodar krai and Belgorod oblast in the space of principal components revealed a geographically specific pattern of the population clustering. The data on mtDNA polymorphism indicated pronounced differentiation of Eastern and Western Iranians. The latter were characterized by a mtDNA group composition similar to that in Eastern Slavs. The historical role of the Caspian populations in the formation of the
population of Southeastern Europe is discussed.
INTRODUCTION
Since ancient times, the population inhabiting western regions of the Central Asia and Iranian upland
played the key role in the peopling of East European
territories. It is suggested that one of the routes of the
Homo sapiens sapiens penetration to Europe passed
though the Caspian regions. Later, during the
Mesolithic, the Caspian regions and refuges at the south
of Eastern Europe were the starting points for recolonization of the European territories [1, 2]. During the
Bronze Age, cattle-breeder tribes from the Caspian
regions settled in the European territories [3, 4].
According to paleoanthropological data, during Scythian time (the early Iron Age) Eastern European steppes
were the territories of activity of tribes belonging to the
Scythian confederation [4]. Apparently, exactly Iranian
tribes played an important role at the first stages of
Scythian ethnogeny. Later Scythians spread over wide
territories of Europe, Central Asia, and Southern Siberia, accumulating many ethnic components. The Iranian substrate also played a significant part in the formation of Eastern Slavs, specifically, Ukrainians and
southern ethnic territorial groups of Russians. According to anthropological and archaeological data, in early
Middle Ages Iranian-Slavic symbiosis (Chernyakhovskaya culture) was a typical feature of the population of East European steppes [5, 6]. In view of this, it
is likely that Iranian, or Iranianized tribes could have
been affiliated with Eastern Slavs.
The data on biochemical and molecular genetics
generally agree with the ideas of anthropologists,
archaeologists, and linguists considered above. Gene
435
mtDNA
group
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H
V
HV*
U
K
J
T
I
W
X
M:
C
D
E
G
A
B
F
Note: Groups of mtDNA types were denoted according to the classification suggested in [1315]. Positions of polymorphic
restriction sites are indicated relative to the Cambridge Reference Sequence of human mtDNA [16].
436
MALYARCHUK et al.
Table 2. Distribution (in %) of mtDNA type groups among the populations of Southeastern Europe, Caucasus, and the Caspian region
Population
mtDNA
group
Russians
(Krasnodar)1
Russians
Western
Ukrainians
(Belgorod)1
Iranians2
Eastern
Iranians
Turkmens
Azerbaijanians2
Armenians2
Adygeians3
30.36
30.0
38.78
37.68
41.7
43.56
19.23
29.17
8.16
7.25
5.6
7.92
3.85
4.17
HV*
4.08
2.9
1.98
8.0
7.69
4.17
7.33
18.37
11.59
8.3
14.85
8.0
7.69
4.17
8.38
4.0
12.24
8.69
8.3
8.91
16.0
15.38
16.67
11.52
14.0
10.2
18.84
16.7
8.91
24.0
3.85
16.67
20.94
32.0
1.45
8.3
6.93
4.0
2.08
7.33
2.0
1.45
2.8
2.97
4.0
7.69
4.17
1.05
2.0
2.04
4.35
2.97
4.0
2.08
1.57
1.45
2.8
0.99
4.17
2.62
M*
4.0
1.45
7.69
4.17
6.0
4.0
7.69
E/G
3.85
4..0
8.0
0.52
2.9
5.6
12.0
8.33
8.38
10.0
6.13
15.38
Turkmens and Eastern Iranians is most likely associated with the processes of settling of the Turkic tribes.
These tribes were initially formed in the Central Asia
among the mixed EuropeanMongoloid forms [4]. The
data on genetic differentiation of Iranian populations do
not conflict with historical data, because it is known
that only central and eastern parts of Iran were included
into the ethnic territories of Persians, but the western
and southeastern parts of Iran since ancient times were
inhabited by the populations of another origin (Azerbaijanians, Kurds, Lurs, Balochi, etc.) [19]. For these
reasons, the revealed differences in the structure of
mtDNA types in Iranians can be explained not only by
the presence of the Mongoloid component in Eastern
Iranians, but also by interethnic differences in the structure of the European component in Western and Eastern
Iranians. This proposal, however, requires detailed
examination of mtDNA variability in different ethnic
territorial groups of Iran.
The figure illustrates the distribution of the examined populations in the space of the principal components. Factor analysis revealed two groups of related
populations. The first group is comprised of Armenians
and Azerbaijanians (Adygeians are located somewhat
apart from them), while the second group is represented
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Table 3. Euclidean distances between populations of southern Eastern Europe, the Caucasus, and Caspian region based on
mtDNA polymorphism data
Population
1. Russians (Krasnodar)1
0.13
0.17
0.12
0.46
0.29
0.21
0.21
0.30
2. Russians (Belgorod)1
0.13
0.11
0.14
0.42
0.31
0.16
0.15
0.22
3. Ukrainians
0.17
0.11
0.13
0.46
0.33
0.18
0.16
0.24
0.12
0.14
0.13
0.51
0.35
0.24
0.23
0.33
5. Eastern Iranians
0.46
0.42
0.46
0.51
0.32
0.33
0.33
0.35
6. Turkmens
0.29
0.31
0.33
0.35
0.32
0.22
0.27
0.34
4. Western
7.
Iranians2
Azerbaijanians2
0.21
0.16
0.18
0.24
0.33
0.22
0.12
0.18
8. Armenians2
0.21
0.15
0.16
0.23
0.33
0.27
0.12
0.17
Adygeians3
0.30
0.22
0.24
0.33
0.34
0.18
0.17
9.
0.35
1
Note: Data on mtDNA polymorphism from the following studies were used: [17], [14], [13].
2
3
5
4
8
0.5
7
9
0.7
0.9
1.1
Principal component 1
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MALYARCHUK et al.
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